• 5882 Citations
  • 42 h-Index
19942019
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Research Output 1994 2019

  • 5882 Citations
  • 42 h-Index
  • 130 Article
  • 1 Chapter
  • 1 Review article
2013
21 Citations (Scopus)

Mechanism of the Sex Difference in Endothelial Dysfunction after Stroke

Davis, C., Fairbanks, S. L. & Alkayed, N., Aug 2013, In : Translational Stroke Research. 4, 4, p. 381-389 9 p.

Research output: Contribution to journalArticle

Sex Characteristics
Stroke
Brain Ischemia
Epoxide Hydrolases
Vasodilation
22 Citations (Scopus)

Role of Endothelial Soluble Epoxide Hydrolase in Cerebrovascular Function and Ischemic Injury

Zhang, W., Davis, C., Edin, M. L., Lee, C. R., Zeldin, D. C. & Alkayed, N., Apr 9 2013, In : PLoS One. 8, 4, e61244.

Research output: Contribution to journalArticle

epoxide hydrolase
Epoxide Hydrolases
mice
Wounds and Injuries
infarction
22 Citations (Scopus)

Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus

Jouihan, S. A., Zuloaga, K. L., Zhang, W., Shangraw, R., Krasnow, S., Marks, D. & Alkayed, N., Oct 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 10, p. 1650-1656 7 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Streptozocin
Type 1 Diabetes Mellitus
Stroke
Hyperglycemia
14 Citations (Scopus)

Soluble epoxide hydrolase dimerization is required for hydrolase activity

Nelson, J. W., Subrahmanyan, R. M., Summers, S. A., Xiao, X. & Alkayed, N., Mar 15 2013, In : Journal of Biological Chemistry. 288, 11, p. 7697-7703 7 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Dimerization
Hydrolases
Polymorphism
Mutation
2012

Erratum: Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion (Journal of Neurochemistry (2012) 121 (680-692)

Di Domenico, F., Casalena, G., Jia, J., Sultana, R., Barone, E., Cai, J., Pierce, W. M., Cini, C., Mancuso, C., Perluigi, M., Davis, C., Alkayed, N. & Butterfield, A. D., Sep 2012, In : Journal of Neurochemistry. 122, 5, p. 1093 1 p.

Research output: Contribution to journalArticle

Neurochemistry
Proteome
Brain Ischemia
Sex Characteristics
Reperfusion
32 Citations (Scopus)

Intrastriatal B-cell administration limits infarct size after stroke in B-cell deficient mice

Chen, Y., Bodhankar, S., Murphy, S. J., Vandenbark, A., Alkayed, N. & Offner, H., Dec 2012, In : Metabolic Brain Disease. 27, 4, p. 487-493 7 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Stroke
Cells
Regulatory B-Lymphocytes
Middle Cerebral Artery Infarction
27 Citations (Scopus)

Mechanism of the sex difference in neuronal ischemic cell death

Fairbanks, S. L., Young, J. M., Nelson, J. W., Davis, C., Koerner, I. & Alkayed, N., Sep 6 2012, In : Neuroscience. 219, p. 183-191 9 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Sex Characteristics
Cell Death
Neurons
Hydrolases
17 Citations (Scopus)

Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion

Di Domenico, F., Casalena, G., Jia, J., Sultana, R., Barone, E., Cai, J., Pierce, W. M., Cini, C., Mancuso, C., Perluigi, M., Davis, C., Alkayed, N. & Butterfield, A. D., May 2012, In : Journal of Neurochemistry. 121, 4, p. 680-692 13 p.

Research output: Contribution to journalArticle

Signal transduction
Proteome
Transcription
Brain Ischemia
Sex Characteristics
22 Citations (Scopus)

Soluble epoxide hydrolase: Sex differences and role in endothelial cell survival

Gupta, N. C., Davis, C., Nelson, J. W., Young, J. M. & Alkayed, N., Aug 2012, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 32, 8, p. 1936-1942 7 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Sex Characteristics
Cell Survival
Endothelial Cells
Oxygen
1 Citation (Scopus)

Soluble epoxide hydrolase as a stroke target

Nelson, J. W. & Alkayed, N., Jan 1 2012, Translational Stroke Research: From Target Selection to Clinical Trials. Springer New York, p. 277-294 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epoxide Hydrolases
Stroke
Brain Diseases
Brain Ischemia
Industry
2011
7 Citations (Scopus)

Endothelium-derived hyperpolarizing factor in the brain: Influence of sex, vessel size and disease state

Davis, C., Siler, D. A. & Alkayed, N., May 2011, In : Women's Health. 7, 3, p. 293-303 11 p.

Research output: Contribution to journalArticle

Vascular Diseases
Endothelium
Blood Vessels
Stroke
Tunica Intima
29 Citations (Scopus)

Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures

Abdu, E., Bruun, D. A., Yang, D., Yang, J., Inceoglu, B., Hammock, B. D., Alkayed, N. & Lein, P. J., May 2011, In : Journal of Neurochemistry. 117, 4, p. 632-642 11 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Cell culture
Neurons
Cell Culture Techniques
Sensory Receptor Cells
24 Citations (Scopus)

In vivo optical imaging of revascularization after brain trauma in mice

Yali, J., Grafe, M., Gruber, A., Alkayed, N. & Wang, R. K., Jan 2011, In : Microvascular Research. 81, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

Angiography
Optical Imaging
Brain
Imaging techniques
Epoxide Hydrolases
2010
102 Citations (Scopus)

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice

Lee, C. R., Imig, J. D., Edin, M. L., Foley, J., DeGraff, L. M., Bradbury, J. A., Graves, J. P., Lih, F. B., Clark, J., Myers, P., Perrow, A. L., Lepp, A. N., Kannon, M. A., Ronnekleiv, O., Alkayed, N., Falck, J. R., Tomer, K. B. & Zeldin, D. C., 2010, In : FASEB Journal. 24, 10, p. 3770-3781 12 p.

Research output: Contribution to journalArticle

Renal Hypertension
Blood pressure
Cytochrome P-450 Enzyme System
Transgenic Mice
Blood Pressure
78 Citations (Scopus)

Epoxyeicosanoid signaling in CNS function and disease

Iliff, J., Jia, J., Nelson, J., Goyagi, T., Klaus, J. & Alkayed, N., Apr 2010, In : Prostaglandins and Other Lipid Mediators. 91, 3-4, p. 68-84 17 p.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Neurology
Central Nervous System
Brain Ischemia
Cytochrome P-450 Enzyme System
20 Citations (Scopus)

Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons

Iliff, J., Fairbanks, S. L., Balkowiec, A. & Alkayed, N., Dec 2010, In : Journal of Neurochemistry. 115, 6, p. 1530-1542 13 p.

Research output: Contribution to journalArticle

Trigeminal Ganglion
Calcitonin Gene-Related Peptide
Neuropeptides
Neurons
Acids
25 Citations (Scopus)

Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: Role of STAT3 signaling

Merke, M. J., Liu, L., Cao, Z., Packwood, W., Young, J., Alkayed, N. & Van Winkle, D. M., 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 2

Research output: Contribution to journalArticle

Epoxide Hydrolases
Cardiac Myocytes
Cytoprotection
Small Interfering RNA
Ischemia
12 Citations (Scopus)

Involvement of stat3 in mouse brain development and sexual dimorphism: A proteomics approach

Di Domenico, F., Casalena, G., Sultana, R., Cai, J., Pierce, W. M., Perluigi, M., Cini, C., Baracca, A., Solaini, G., Lenaz, G., Jia, J., Dziennis, S., Murphy, S. J., Alkayed, N. & Butterfield, D. A., Nov 29 2010, In : Brain Research. 1362, p. 1-12 12 p.

Research output: Contribution to journalArticle

Sex Characteristics
Proteomics
Brain
Maintenance
Nerve Tissue
2009
14 Citations (Scopus)

Brainstem control of cerebral blood flow and application to acute vasospasm following experimental subarachnoid hemorrhage

Cetas, J., Lee, D. R., Alkayed, N., Wang, R., Iliff, J. & Heinricher, M., Oct 6 2009, In : Neuroscience. 163, 2, p. 719-729 11 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Subarachnoid Hemorrhage
Brain Stem
Perfusion
Ischemia

Comments

Alkayed, N., Jan 2009, In : Acta Neurochirurgica. 151, 12, p. 1692 1 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
Response Elements
Cyclic AMP
Carrier Proteins
Phosphorylation
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
52 Citations (Scopus)
Epoxide Hydrolases
Cerebrovascular Circulation
Vasodilation
Ganglia
Trigeminal Ganglion
46 Citations (Scopus)

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Guan, D., Zhu, W., Alkayed, N., Wang, M. M., Hua, Z. & Xu, Y., Jan 2009, In : Experimental Neurology. 215, 1, p. 48-52 5 p.

Research output: Contribution to journalArticle

Estradiol
Estrogens
Brain Ischemia
Stroke
Apoptosis
67 Citations (Scopus)

Mechanisms of gender-linked ischemic brain injury

Liu, M., Dziennis, S., Hurn, P. D. & Alkayed, N., 2009, In : Restorative Neurology and Neuroscience. 27, 3, p. 163-179 17 p.

Research output: Contribution to journalArticle

Sex Characteristics
Brain Injuries
Stroke
Progesterone
Cell Death
27 Citations (Scopus)
brain damage
plastic properties
blood
Plasticity
mice
53 Citations (Scopus)

Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia

Zhang, W., Iliff, J., Campbell, C. J., Wang, R. K., Hurn, P. D. & Alkayed, N., Aug 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 8, p. 1475-1481 7 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Brain Ischemia
Blood Vessels
Middle Cerebral Artery Infarction
Knockout Mice
44 Citations (Scopus)
Epoxide Hydrolases
Brain Injuries
Stroke
Eicosanoids
Gene Deletion
2008
15 Citations (Scopus)

Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats

Dziennis, S., Yang, D., Cheng, J., Anderson, K. A., Alkayed, N., Hurn, P. D. & Lein, P. J., Apr 2008, In : Environmental Health Perspectives. 116, 4, p. 474-480 7 p.

Research output: Contribution to journalArticle

Chlorodiphenyl (54% Chlorine)
Polychlorinated Biphenyls
Rats
PCB
Stroke
7 Citations (Scopus)

In vivo cerebrovascular effects of cocaine- and amphetamine-regulated transcript (CART) peptide

Iliff, J., Alkayed, N., Golshani, K. J., Weinstein, J., Traystman, R. J. & West, G. A., Jul 2008, In : Journal of Cardiovascular Pharmacology. 52, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Peptides
Constriction
Arterioles
20 Citations (Scopus)

Lack of sex-linked differences in cerebral edema and aquaporin-4 expression after experimental stroke

Liu, X., Zhang, W., Alkayed, N., Froehner, S. C., Adams, M. E., Amiry-Moghaddam, M., Ottersen, O. P., Hurn, P. D. & Bhardwaj, A., Dec 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 12, p. 1898-1906 9 p.

Research output: Contribution to journalArticle

Aquaporin 4
Brain Edema
Sex Characteristics
Stroke
Cerebrovascular Circulation
93 Citations (Scopus)

Role of Signal Transducer and activator of transcription 3 in neuronal survival and regeneration

Dziennis, S. & Alkayed, N., 2008, In : Reviews in the Neurosciences. 19, 4-5, p. 341-361 21 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Transducers
Regeneration
Spinal Nerves
Peripheral Nervous System
50 Citations (Scopus)

Soluble epoxide hydrolase: Regulation by estrogen and role in the inflammatory response to cerebral ischemia

Koerner, I., Zhang, W., Cheng, J., Parker, S., Hurn, P. D. & Alkayed, N., 2008, In : Frontiers in bioscience : a journal and virtual library. 13, 8, p. 2833-2841 9 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Brain Ischemia
Estrogens
Estradiol
Middle Cerebral Artery Infarction
139 Citations (Scopus)

Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Zhang, W., Otsuka, T., Sugo, N., Ardeshiri, A., Alhadid, Y. K., Iliff, J., De Barber, A., Koop, D. & Alkayed, N., Jul 2008, In : Stroke. 39, 7, p. 2073-2078 6 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Gene Deletion
Brain Ischemia
Knockout Mice
Middle Cerebral Artery Infarction
44 Citations (Scopus)

Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation

Hutchens, M., Nakano, T., Dunlap, J., Traystman, R. J., Hurn, P. D. & Alkayed, N., Jan 2008, In : Resuscitation. 76, 1, p. 89-94 6 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Cardiopulmonary Resuscitation
Gene Deletion
Heart Arrest
Kidney
79 Citations (Scopus)

Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo

Motoki, A., Merkel, M., Packwood, W. H., Cao, Z., Liu, L., Iliff, J., Alkayed, N. & Van Winkle, D. M., Nov 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 295, 5

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Epoxide Hydrolases
Gene Deletion
Reperfusion Injury
Myocardial Ischemia
2007
45 Citations (Scopus)

A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat

Iliff, J., Close, L. N., Selden, N. & Alkayed, N., Jul 2007, In : Experimental Physiology. 92, 4, p. 653-658 6 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Epoxide Hydrolases
Eicosanoids
Cytochrome P-450 Enzyme System
Acids
40 Citations (Scopus)

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. & Hurn, P. D., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Dihydrotestosterone
Wounds and Injuries
Middle Cerebral Artery Infarction
Genes
Reperfusion
32 Citations (Scopus)

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. & Hurn, P. D., Sep 7 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 9, p. 1553-1562 10 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Androgens
Wounds and Injuries
Brain Ischemia
Reperfusion
Estradiol
Middle Cerebral Artery Infarction
Brain
Estrogens
Brain Ischemia

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Yang, Z., Wang, L., Hua, Z., Hurn, P. D., Alkayed, N. & Xu, Y., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Estradiol
Estrogens
Stroke
Apoptosis
anti-Fas monoclonal antibody
46 Citations (Scopus)

Mitochondrial mechanism of neuroprotection by CART

Mao, P., Ardeshiri, A., Jacks, R., Yang, S., Hurn, P. D. & Alkayed, N., Aug 2007, In : European Journal of Neuroscience. 26, 3, p. 624-632 9 p.

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Adenosine Triphosphate
Oxygen
Glucose
92 Citations (Scopus)

Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury

Koerner, I., Jacks, R., De Barber, A., Koop, D., Mao, P., Grant, D. F. & Alkayed, N., Apr 25 2007, In : Journal of Neuroscience. 27, 17, p. 4642-4649 8 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Wounds and Injuries
Genes
Cell Death
Enzymes

Role of MAPK in neuroprotection by cart in ischemic stroke

Xu, Y., Jia, J., Hua, Z., Hurn, P. & Alkayed, N., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Stroke
Small Interfering RNA
Middle Cerebral Artery Infarction
95 Citations (Scopus)

Role of P450 aromatase in sex-specific astrocytic cell death

Liu, M., Hurn, P. D., Roselli, C. & Alkayed, N., Jan 5 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 1, p. 135-141 7 p.

Research output: Contribution to journalArticle

Aromatase
Cell Death
Astrocytes
Oxygen
Glucose
79 Citations (Scopus)

Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection

Dziennis, S., Jia, T., Ronnekleiv, O., Hurn, P. D. & Alkayed, N., Jul 4 2007, In : Journal of Neuroscience. 27, 27, p. 7268-7274 7 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Estradiol
Middle Cerebral Artery Infarction
Transcriptional Activation
Microtubule-Associated Proteins

Sex-specific anti-oxidant capacities in astrocytes

Liu, M., Alkayed, N., Oyarzabal, E. & Hurn, P. D., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Oxidants
Astrocytes
Glutathione Peroxidase
Catalase
Superoxide Dismutase
56 Citations (Scopus)

Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2

Yang, S., Bhardwaj, A., Cheng, J., Alkayed, N., Hurn, P. D. & Kirsch, J., May 2007, In : Anesthesia and Analgesia. 104, 5, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

sigma Receptors
Oxygen
Glucose
In Situ Nick-End Labeling
DNA Damage
143 Citations (Scopus)

Soluble epoxide hydrolase: A novel therapeutic target in stroke

Zhang, W., Koerner, I., Noppens, R., Grafe, M., Tsai, H. J., Morisseau, C., Luria, A., Hammock, B. D., Falck, J. R. & Alkayed, N., Dec 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 12, p. 1931-1940 10 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
lauric acid
Stroke
Cerebrovascular Circulation
Esters

Soluble epoxide hydrolase: Sex differences and role in estrogen-mediated neuroprotection

Zhang, W., Iliff, J., Alhadid, Y. K., Ardeshiri, A., Koerner, I., Hurn, P. D. & Alkayed, N., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Epoxide Hydrolases
Sex Characteristics
Estrogens
Reperfusion
Middle Cerebral Artery Infarction
2006
15 Citations (Scopus)

Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA

Joh, H. D., Searles, R. V., Selmanoff, M., Alkayed, N., Koehler, R. C., Hurn, P. D. & Murphy, S. J., Apr 2006, In : Journal of Cerebral Blood Flow and Metabolism. 26, 4, p. 518-526 9 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Estradiol
Messenger RNA
Brain
Middle Cerebral Artery Infarction