• 6118 Citations
  • 43 h-Index
1994 …2020

Research output per year

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Research Output

2013

Mechanism of the Sex Difference in Endothelial Dysfunction after Stroke

Davis, C. M., Fairbanks, S. L. & Alkayed, N. J., Aug 1 2013, In : Translational Stroke Research. 4, 4, p. 381-389 9 p.

Research output: Contribution to journalReview article

23 Scopus citations

Role of Endothelial Soluble Epoxide Hydrolase in Cerebrovascular Function and Ischemic Injury

Zhang, W., Davis, C. M., Edin, M. L., Lee, C. R., Zeldin, D. C. & Alkayed, N. J., Apr 9 2013, In : PloS one. 8, 4, e61244.

Research output: Contribution to journalArticle

26 Scopus citations

Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus

Jouihan, S. A., Zuloaga, K. L., Zhang, W., Shangraw, R. E., Krasnow, S. M., Marks, D. L. & Alkayed, N. J., Oct 1 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 10, p. 1650-1656 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Soluble epoxide hydrolase dimerization is required for hydrolase activity

Nelson, J. W., Subrahmanyan, R. M., Summers, S. A., Xiao, X. & Alkayed, N. J., Mar 15 2013, In : Journal of Biological Chemistry. 288, 11, p. 7697-7703 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Erratum: Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion (Journal of Neurochemistry (2012) 121 (680-692)

Di Domenico, F., Casalena, G., Jia, J., Sultana, R., Barone, E., Cai, J., Pierce, W. M., Cini, C., Mancuso, C., Perluigi, M., Davis, C. M., Alkayed, N. J. & Butterfield, A. D., Sep 1 2012, In : Journal of Neurochemistry. 122, 5, 1 p.

Research output: Contribution to journalComment/debate

Intrastriatal B-cell administration limits infarct size after stroke in B-cell deficient mice

Chen, Y., Bodhankar, S., Murphy, S. J., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Dec 1 2012, In : Metabolic brain disease. 27, 4, p. 487-493 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mechanism of the sex difference in neuronal ischemic cell death

Fairbanks, S. L., Young, J. M., Nelson, J. W., Davis, C. M., Koerner, I. P. & Alkayed, N. J., Sep 6 2012, In : Neuroscience. 219, p. 183-191 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion

Di Domenico, F., Casalena, G., Jia, J., Sultana, R., Barone, E., Cai, J., Pierce, W. M., Cini, C., Mancuso, C., Perluigi, M., Davis, C. M., Alkayed, N. J. & Butterfield, A. D., May 1 2012, In : Journal of Neurochemistry. 121, 4, p. 680-692 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Soluble epoxide hydrolase: Sex differences and role in endothelial cell survival

Gupta, N. C., Davis, C. M., Nelson, J. W., Young, J. M. & Alkayed, N. J., Aug 1 2012, In : Arteriosclerosis, thrombosis, and vascular biology. 32, 8, p. 1936-1942 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Soluble epoxide hydrolase as a stroke target

Nelson, J. W. & Alkayed, N., Jan 1 2012, Translational Stroke Research: From Target Selection to Clinical Trials. Springer New York, p. 277-294 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2011

Endothelium-derived hyperpolarizing factor in the brain: Influence of sex, vessel size and disease state

Davis, C. M., Siler, D. A. & Alkayed, N. J., May 1 2011, In : Women's Health. 7, 3, p. 293-303 11 p.

Research output: Contribution to journalReview article

7 Scopus citations

Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures

Abdu, E., Bruun, D. A., Yang, D., Yang, J., Inceoglu, B., Hammock, B. D., Alkayed, N. J. & Lein, P. J., May 1 2011, In : Journal of neurochemistry. 117, 4, p. 632-642 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

In vivo optical imaging of revascularization after brain trauma in mice

Jia, Y., Grafe, M. R., Gruber, A., Alkayed, N. J. & Wang, R. K., Jan 1 2011, In : Microvascular Research. 81, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice

Lee, C. R., Imig, J. D., Edin, M. L., Foley, J., DeGraff, L. M., Bradbury, J. A., Graves, J. P., Lih, F. B., Clark, J., Myers, P., Perrow, A. L., Lepp, A. N., Kannon, M. A., Ronnekleiv, O. K., Alkayed, N. J., Falck, J. R., Tomer, K. B. & Zeldin, D. C., Oct 2010, In : FASEB Journal. 24, 10, p. 3770-3781 12 p.

Research output: Contribution to journalArticle

107 Scopus citations

Epoxyeicosanoid signaling in CNS function and disease

Iliff, J. J., Jia, J., Nelson, J., Goyagi, T., Klaus, J. & Alkayed, N. J., Apr 1 2010, In : Prostaglandins and Other Lipid Mediators. 91, 3-4, p. 68-84 17 p.

Research output: Contribution to journalReview article

83 Scopus citations
20 Scopus citations

Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: Role of STAT3 signaling

Merke, M. J., Liu, L., Cao, Z., Packwood, W., Young, J., Alkayed, N. J. & Van Winkle, D. M., 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 2, p. H679-H687

Research output: Contribution to journalArticle

25 Scopus citations

Involvement of stat3 in mouse brain development and sexual dimorphism: A proteomics approach

Di Domenico, F., Casalena, G., Sultana, R., Cai, J., Pierce, W. M., Perluigi, M., Cini, C., Baracca, A., Solaini, G., Lenaz, G., Jia, J., Dziennis, S., Murphy, S. J., Alkayed, N. J. & Butterfield, D. A., Nov 29 2010, In : Brain research. 1362, p. 1-12 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2009
15 Scopus citations

Comments

Alkayed, N. J., Jan 1 2009, In : Acta Neurochirurgica. 151, 12, 1 p.

Research output: Contribution to journalComment/debate

15 Scopus citations

Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels

Iliff, J. J., Wang, R., Zeldin, D. C. & Alkayed, N. J., May 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 296, 5, p. H1352-H1363

Research output: Contribution to journalArticle

55 Scopus citations

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Guan, D., Zhu, W., Alkayed, N. J., Wang, M. M., Hua, Z. & Xu, Y., Jan 1 2009, In : Experimental Neurology. 215, 1, p. 48-52 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Mechanisms of gender-linked ischemic brain injury

Liu, M., Dziennis, S., Hurn, P. D. & Alkayed, N. J., Aug 10 2009, In : Restorative Neurology and Neuroscience. 27, 3, p. 163-179 17 p.

Research output: Contribution to journalReview article

68 Scopus citations
27 Scopus citations

Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia

Zhang, W., Iliff, J. J., Campbell, C. J., Wang, R. K., Hurn, P. D. & Alkayed, N. J., Aug 1 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 8, p. 1475-1481 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Soluble epoxide hydrolase inhibition: Targeting multiple mechanisms of ischemic brain injury with a single agent

Iliff, J. J. & Alkayed, N. J., Jun 19 2009, In : Future Neurology. 4, 2, p. 179-199 21 p.

Research output: Contribution to journalReview article

49 Scopus citations
2008

Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats

Dziennis, S., Yang, D., Cheng, J., Anderson, K. A., Alkayed, N. J., Hurn, P. D. & Lein, P. J., Apr 2008, In : Environmental health perspectives. 116, 4, p. 474-480 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

In vivo cerebrovascular effects of cocaine- and amphetamine-regulated transcript (CART) peptide

Iliff, J. J., Alkayed, N. J., Golshani, K. J., Weinstein, J., Traystman, R. J. & West, G. A., Jul 1 2008, In : Journal of Cardiovascular Pharmacology. 52, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Lack of sex-linked differences in cerebral edema and aquaporin-4 expression after experimental stroke

Liu, X., Zhang, W., Alkayed, N. J., Froehner, S. C., Adams, M. E., Amiry-Moghaddam, M., Ottersen, O. P., Hurn, P. D. & Bhardwaj, A., Dec 1 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 12, p. 1898-1906 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Role of Signal Transducer and activator of transcription 3 in neuronal survival and regeneration

Dziennis, S. & Alkayed, N. J., Jan 1 2008, In : Reviews in the Neurosciences. 19, 4-5, p. 341-361 21 p.

Research output: Contribution to journalReview article

96 Scopus citations

Soluble epoxide hydrolase: Regulation by estrogen and role in the inflammatory response to cerebral ischemia

Koerner, I. P., Zhang, W., Cheng, J., Parker, S., Hurn, P. D. & Alkayed, N. J., May 1 2008, In : Frontiers in Bioscience. 13, 8, p. 2833-2841 9 p.

Research output: Contribution to journalReview article

50 Scopus citations

Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Zhang, W., Otsuka, T., Sugo, N., Ardeshiri, A., Alhadid, Y. K., Iliff, J. J., DeBarber, A. E., Koop, D. R. & Alkayed, N. J., Jul 2008, In : Stroke; a journal of cerebral circulation. 39, 7, p. 2073-2078 6 p.

Research output: Contribution to journalArticle

142 Scopus citations

Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation

Hutchens, M. P., Nakano, T., Dunlap, J., Traystman, R. J., Hurn, P. D. & Alkayed, N. J., Jan 1 2008, In : Resuscitation. 76, 1, p. 89-94 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo

Motoki, A., Merkel, M. J., Packwood, W. H., Cao, Z., Liu, L., Iliff, J., Alkayed, N. J. & Van Winkle, D. M., Nov 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 295, 5, p. H2128-H2134

Research output: Contribution to journalArticle

80 Scopus citations
2007

A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat

Iliff, J. J., Close, L. N., Selden, N. R. & Alkayed, N. J., Jul 2007, In : Experimental physiology. 92, 4, p. 653-658 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. J. & Hurn, P. D., Sep 7 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 9, p. 1553-1562 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. J. & Hurn, P. D., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BO11-06

Research output: Contribution to journalArticle

39 Scopus citations

Estradiol is protective against ischemic brain damage through signal trasducer and activator of transcription 3 (STAT3)

Dziennis, S., Jia, T., Ronnekleiv, O. K., Hurn, P. D. & Alkayed, N. J., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BP8-03U

Research output: Contribution to journalArticle

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Yang, Z., Wang, L., Hua, Z., Hurn, P. D., Alkayed, N. J. & Xu, Y., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BP43-01H

Research output: Contribution to journalArticle

Mitochondrial mechanism of neuroprotection by CART

Mao, P., Ardeshiri, A., Jacks, R., Yang, S., Hurn, P. D. & Alkayed, N. J., Aug 1 2007, In : European Journal of Neuroscience. 26, 3, p. 624-632 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury

Koerner, I. P., Jacks, R., DeBarber, A. E., Koop, D., Mao, P., Grant, D. F. & Alkayed, N. J., Apr 25 2007, In : Journal of Neuroscience. 27, 17, p. 4642-4649 8 p.

Research output: Contribution to journalArticle

92 Scopus citations

Role of MAPK in neuroprotection by cart in ischemic stroke

Xu, Y., Jia, J., Hua, Z., Hurn, P. & Alkayed, N. J., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BO06-01

Research output: Contribution to journalArticle

Role of P450 aromatase in sex-specific astrocytic cell death

Liu, M., Hurn, P. D., Roselli, C. E. & Alkayed, N. J., Jan 5 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 1, p. 135-141 7 p.

Research output: Contribution to journalArticle

100 Scopus citations

Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection

Dziennis, S., Jia, T., Rønnekleiv, O. K., Hurn, P. D. & Alkayed, N. J., Jul 4 2007, In : Journal of Neuroscience. 27, 27, p. 7268-7274 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Sex-specific anti-oxidant capacities in astrocytes

Liu, M., Alkayed, N. J., Oyarzabal, E. & Hurn, P. D., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BP8-02U

Research output: Contribution to journalArticle

Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2

Yang, S., Bhardwaj, A., Cheng, J., Alkayed, N. J., Hurn, P. D. & Kirsch, J. R., May 1 2007, In : Anesthesia and analgesia. 104, 5, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Soluble epoxide hydrolase: Sex differences and role in estrogen-mediated neuroprotection

Zhang, W., Iliff, J. J., Alhadid, Y. K., Ardeshiri, A., Koerner, I. P., Hurn, P. D. & Alkayed, N. J., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BP37-03H

Research output: Contribution to journalArticle

Soluble epoxide hydrolase: A novel therapeutic target in stroke

Zhang, W., Koerner, I. P., Noppens, R., Grafe, M., Tsai, H. J., Morisseau, C., Luria, A., Hammock, B. D., Falck, J. R. & Alkayed, N. J., Dec 1 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 12, p. 1931-1940 10 p.

Research output: Contribution to journalArticle

148 Scopus citations
2006

Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA

Joh, H. D., Searles, R. V., Selmanoff, M., Alkayed, N. J., Koehler, R. C., Hurn, P. D. & Murphy, S. J., Apr 1 2006, In : Journal of Cerebral Blood Flow and Metabolism. 26, 4, p. 518-526 9 p.

Research output: Contribution to journalArticle

15 Scopus citations