• 5882 Citations
  • 42 h-Index
19942019
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Research Output 1994 2019

  • 5882 Citations
  • 42 h-Index
  • 130 Article
  • 1 Chapter
  • 1 Review article
2006
94 Citations (Scopus)

Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection

Xu, Y., Zhang, W., Klaus, J., Young, J., Koerner, I., Sheldahl, L. C., Hurn, P. D., Martínez-Murillo, F. & Alkayed, N., Sep 26 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 39, p. 14489-14494 6 p.

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Estradiol
Brain Injuries
Estrogens
2005
20 Citations (Scopus)

Cocaine- and amphetamine-regulated transcript (CART) peptide: A vasoactive role in the cerebral circulation

Iliff, J., Alkayed, N., Gloshani, K. J., Traystman, R. J. & West, G. A., Oct 2005, In : Journal of Cerebral Blood Flow and Metabolism. 25, 10, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Amphetamine
Cocaine
Peptides
Arterioles
74 Citations (Scopus)
Hypoxia-Inducible Factor 1
Astrocytes
Ischemic Preconditioning
Electrophoretic Mobility Shift Assay
Cytochrome P-450 Enzyme System
2004
38 Citations (Scopus)

Cytochrome P450 in neurological disease

Liu, M., Hurn, P. D. & Alkayed, N., Jun 2004, In : Current Drug Metabolism. 5, 3, p. 225-234 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Brain
Neurotransmitter Agents
Cerebrovascular Circulation
Cholesterol
61 Citations (Scopus)

Dependency of Cortical Functional Hyperemia to Forepaw Stimulation on Epoxygenase and Nitric Oxide Synthase Activities in Rats

Peng, X., Zhang, C., Alkayed, N., Harder, D. R. & Koehler, R. C., May 2004, In : Journal of Cerebral Blood Flow and Metabolism. 24, 5, p. 509-517 9 p.

Research output: Contribution to journalArticle

Hyperemia
Nitric Oxide Synthase
Arginine
Miconazole
Astrocytes
2003
15 Citations (Scopus)
Brain Ischemia
Genes
Reperfusion
Cerebrovascular Circulation
Arteries
41 Citations (Scopus)

High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats

Antezana, D. F., Clatterbuck, R. E., Alkayed, N., Murphy, S. J., Anderson, L. G., Frazier, J., Hurn, P. D., Traystman, R. J. & Tamargo, R. J., Apr 1 2003, In : Journal of Neurosurgery. 98, 4, p. 860-866 7 p.

Research output: Contribution to journalArticle

Corpus Striatum
Ibuprofen
Middle Cerebral Artery Infarction
Intercellular Adhesion Molecule-1
Cerebrovascular Circulation
30 Citations (Scopus)

Mechanisms of ischemic brain damage

Bhardwaj, A., Alkayed, N., Kirsch, J. & Hurn, P. D., Mar 2003, In : Current Cardiology Reports. 5, 2, p. 160-167 8 p.

Research output: Contribution to journalArticle

Brain Ischemia
Brain
Perioperative Period
Heart Arrest
Brain Injuries
2002
89 Citations (Scopus)

Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack

Alkayed, N., Goyagi, T., Joh, H. D., Klaus, J., Harder, D. R., Traystman, R. J. & Hurn, P. D., 2002, In : Stroke. 33, 6, p. 1677-1684 8 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Up-Regulation
Cerebrovascular Circulation
Middle Cerebral Artery Infarction
Stroke

Regulation of the cerebral circulation by cytochrome P450 epoxygenase activity

Peng, X., Carhuapoma, J. R., Bhardwaj, A., Alkayed, N., Harder, D. R., Traystman, R. J. & Koehler, R. C., Jul 1 2002, In : International Congress Series. 1235, C, p. 289-295 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Vibrissae
Cytochrome P-450 Enzyme System
Miconazole
Microdialysis
88 Citations (Scopus)

Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors

Peng, X., Carhuapoma, J. R., Bhardwaj, A., Alkayed, N., Falck, J. R., Harder, D. R., Traystman, R. J. & Koehler, R. C., Nov 1 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 5 52-5

Research output: Contribution to journalArticle

Vibrissae
Hyperemia
Miconazole
Glutamic Acid
Chloralose
2001
39 Citations (Scopus)

Anesthetic choice of halothane versus propofol impact on experimental perioperative stroke

Bhardwaj, A., Castro, A. F., Alkayed, N., Hurn, P. D. & Kirsch, J., 2001, In : Stroke. 32, 8, p. 1920-1925 6 p.

Research output: Contribution to journalArticle

Propofol
Halothane
Anesthetics
Stroke
Middle Cerebral Artery Infarction
166 Citations (Scopus)

Estrogen and Bcl-2: Gene induction and effect of transgene in experimental stroke

Alkayed, N., Goto, S., Sugo, N., Joh, H. D., Klaus, J., Crain, B. J., Bernard, O., Traystman, R. J. & Hurn, P. D., Oct 1 2001, In : Journal of Neuroscience. 21, 19, p. 7543-7550 8 p.

Research output: Contribution to journalArticle

bcl-2 Genes
Transgenes
Estrogens
Stroke
Ovariectomy
111 Citations (Scopus)

Experimental stroke in the female diabetic, db/db, mouse

Vannucci, S. J., Willing, L. B., Goto, S., Alkayed, N., Brucklacher, R. M., Wood, T. L., Towfighi, J., Hurn, P. D. & Simpson, I. A., 2001, In : Journal of Cerebral Blood Flow and Metabolism. 21, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

Stroke
Cerebrovascular Circulation
Common Carotid Artery
Brain
Ligation
8 Citations (Scopus)

Gender-based differences in Na +-K + adenosine triphosphatase activity occur in the microcirculation of the diabetic rat brain

Sieber, F. E., Hurn, P., Alkayed, N. & Traystman, R. J., 2001, In : Anesthesiology. 94, 2, p. 372-375 4 p.

Research output: Contribution to journalArticle

Inbred BB Rats
Sodium-Potassium-Exchanging ATPase
Microcirculation
Sex Characteristics
Protein Kinase C
164 Citations (Scopus)

Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke

McCullough, L. D., Alkayed, N., Traystman, R. J., Williams, M. J. & Hurn, P. D., 2001, In : Stroke. 32, 3

Research output: Contribution to journalArticle

Estrogens
Ischemia
Stroke
Cerebrovascular Circulation
Reperfusion
118 Citations (Scopus)

Social stress exacerbates stroke outcome by suppressing Bcl-2 expression

DeVries, A. C., Joh, H. D., Bernard, O., Hattori, K., Hurn, P. D., Traystman, R. J. & Alkayed, N., Sep 25 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 20, p. 11824-11828 5 p.

Research output: Contribution to journalArticle

Stroke
Corticosterone
Psychological Stress
Transgenic Mice
Cerebral Arteries
2000
127 Citations (Scopus)

Estrogen receptor antagonist ICI182,780 exacerbates ischemic injury in female mouse

Sawada, M., Alkayed, N., Goto, S., Grain, B. J., Traystman, R. J., Shaivitz, A., Nelson, R. J. & Hurn, P. D., 2000, In : Journal of Cerebral Blood Flow and Metabolism. 20, 1, p. 112-118 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Wounds and Injuries
Estrogens
Brain
Corpus Striatum
57 Citations (Scopus)

Hypertonic saline worsens infarct volume after transient focal ischemia in rats

Bhardwaj, A., Harukuni, I., Murphy, S. J., Alkayed, N., Crain, B. J., Koehler, R. C., Hurn, P. D. & Traystman, R. J., Jul 2000, In : Stroke. 31, 7, p. 1694-1701 8 p.

Research output: Contribution to journalArticle

Reperfusion
Ischemia
Cerebrovascular Circulation
Middle Cerebral Artery Infarction
Transient Ischemic Attack
5 Citations (Scopus)

Is the acetazolamide test valid for quantitative assessment of maximal cerebral autoregulatory vasodilation? [5] (multiple letters)

Derdeyn, C. P. & Alkayed, N., 2000, In : Stroke. 31, 9, p. 2271-2272 2 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Carbonic Anhydrase Inhibitors
Acetazolamide
Cerebral Arteries
Blood Flow Velocity
290 Citations (Scopus)

Neuroprotective effects of female gonadal steroids in reproductively senescent female rats

Alkayed, N., Murphy, S. J., Traystman, R. J. & Hurn, P. D., Jan 2000, In : Stroke. 31, 1, p. 161-168 8 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Steroids
Progesterone
Brain Injuries
Cerebrovascular Circulation
131 Citations (Scopus)

Stroke in estrogen receptor-α-deficient mice

Sampei, K., Goto, S., Alkayed, N., Crain, B. J., Korach, K. S., Traystman, R. J., Demas, G. E., Nelson, R. J. & Hurn, P. D., Mar 2000, In : Stroke. 31, 3, p. 738-744 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Stroke
Infarction
Middle Cerebral Artery Infarction
Cerebrovascular Circulation
1999
264 Citations (Scopus)

17β-Estradiol reduces stroke injury in estrogen-deficient female animals

Rusa, R., Alkayed, N., Crain, B. J., Traystman, R. J., Kimes, A. S., London, E. D., Klaus, J. A. & Hurn, P. D., Aug 1999, In : Stroke. 30, 8, p. 1665-1670 6 p.

Research output: Contribution to journalArticle

Estradiol
Estrogens
Stroke
Middle Cerebral Artery Infarction
Putamen
127 Citations (Scopus)

Heme oxygenase-2 is neuroprotective in cerebral ischemia

Doré, S., Sampei, K., Goto, S., Alkayed, N., Guastella, D., Blackshaw, S., Gallagher, M., Traystman, R. J., Hurn, P. D., Koehler, R. C. & Snyder, S. H., 1999, In : Molecular Medicine. 5, 10, p. 656-663 8 p.

Research output: Contribution to journalArticle

Brain Ischemia
Bilirubin
Heme
Brain
Stroke
1998
8 Citations (Scopus)

Estrogen-enhanced expression of bcl-2 mRNA in rat brain after experimental stroke

Alkayed, N., McCune, S. K., Crain, B. J., Traystman, R. J. & Hurn, P. D., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

stroke
estrogens
Rats
Brain
Estrogens
174 Citations (Scopus)

Functional hyperemia in the brain: Hypothesis for astrocyte-derived vasodilator metabolites

Harder, D. R., Alkayed, N., Lange, A. R., Gebremedhin, D. & Roman, R. J., Jan 1998, In : Stroke. 29, 1, p. 229-234 6 p.

Research output: Contribution to journalArticle

Hyperemia
Vasodilator Agents
Astrocytes
Glutamate Receptors
Brain
589 Citations (Scopus)

Gender-linked brain injury in experimental stroke

Alkayed, N., Harukuni, I., Kimes, A. S., London, E. D., Traystman, R. J. & Hurn, P. D., Jan 1998, In : Stroke. 29, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Brain Injuries
Stroke
Ischemia
Laser-Doppler Flowmetry
1997
110 Citations (Scopus)

Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats

Alkayed, N., Birks, E. K., Narayanan, J., Petrie, K. A., Kohler-Cabot, A. E. & Harder, D. R., May 1997, In : Stroke. 28, 5, p. 1066-1072 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Astrocytes
Glutamic Acid
Arachidonic Acid
Miconazole
1996
92 Citations (Scopus)

Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow

Alkayed, N., Birks, E. K., Hudetz, A. G., Roman, R. J., Henderson, L. & Harder, D. R., Oct 1996, In : American Journal of Physiology - Heart and Circulatory Physiology. 40, 4

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Miconazole
Arachidonic Acid
Astrocytes
Brain

Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow

Alkayed, N., Birks, E. K., Hudetz, A. G., Roman, R. J., Henderson, L. & Harder, D. R., Oct 1996, In : American Journal of Physiology - Heart and Circulatory Physiology. 271, 4 40-4

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Miconazole
Arachidonic Acid
Astrocytes
Brain
160 Citations (Scopus)

Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes

Alkayed, N., Narayanan, J., Gebremedhin, D., Medhora, M., Roman, R. J. & Harder, D. R., May 1996, In : Stroke. 27, 5, p. 971-979 9 p.

Research output: Contribution to journalArticle

Astrocytes
Brain
Arachidonic Acid
Microcirculation
Microvessels
1994
23 Citations (Scopus)

Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats

Li, P., Zou, A. P., Alkayed, N., Rusch, N. J. & Harder, D. R., 1994, In : Hypertension. 23, 6, p. 912-918 7 p.

Research output: Contribution to journalArticle

Guanine Nucleotides
Smooth Muscle
Carrier Proteins
GTP-Binding Proteins
Aortic Coarctation