• 6166 Citations
  • 43 h-Index
1994 …2020

Research output per year

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Research Output

2006

Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection

Xu, Y., Zhang, W., Klaus, J., Young, J., Koerner, I., Sheldahl, L. C., Hurn, P. D., Martínez-Murillo, F. & Alkayed, N. J., Sep 26 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 39, p. 14489-14494 6 p.

Research output: Contribution to journalArticle

96 Scopus citations
2005

Cocaine- and amphetamine-regulated transcript (CART) peptide: A vasoactive role in the cerebral circulation

Iliff, J. J., Alkayed, N. J., Gloshani, K. J., Traystman, R. J. & West, G. A., Oct 1 2005, In : Journal of Cerebral Blood Flow and Metabolism. 25, 10, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
75 Scopus citations
2004

Cytochrome P450 in neurological disease

Liu, M., Hurn, P. D. & Alkayed, N. J., Jun 1 2004, In : Current Drug Metabolism. 5, 3, p. 225-234 10 p.

Research output: Contribution to journalReview article

38 Scopus citations

Dependency of Cortical Functional Hyperemia to Forepaw Stimulation on Epoxygenase and Nitric Oxide Synthase Activities in Rats

Peng, X., Zhang, C., Alkayed, N. J., Harder, D. R. & Koehler, R. C., May 2004, In : Journal of Cerebral Blood Flow and Metabolism. 24, 5, p. 509-517 9 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations
2003

Characterization of a new double-filament model of focal cerebral ischemia in heme oxygenase-2-deficient mice

Goto, S., Sampei, K., Alkayed, N. J., Doré, S. & Koehler, R. C., Jul 1 2003, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 285, 1 54-1, p. R222-R230

Research output: Contribution to journalArticle

15 Scopus citations

High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats

Antezana, D. F., Clatterbuck, R. E., Alkayed, N. J., Murphy, S. J., Anderson, L. G., Frazier, J., Hurn, P. D., Traystman, R. J. & Tamargo, R. J., Apr 1 2003, In : Journal of neurosurgery. 98, 4, p. 860-866 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Mechanisms of ischemic brain damage

Bhardwaj, A., Alkayed, N. J., Kirsch, J. R. & Hurn, P. D., Mar 2003, In : Current cardiology reports. 5, 2, p. 160-167 8 p.

Research output: Contribution to journalReview article

31 Scopus citations
2002

Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack

Alkayed, N. J., Goyagi, T., Joh, H. D., Klaus, J., Harder, D. R., Traystman, R. J. & Hurn, P. D., Jun 22 2002, In : Stroke. 33, 6, p. 1677-1684 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Regulation of the cerebral circulation by cytochrome P450 epoxygenase activity

Peng, X., Carhuapoma, J. R., Bhardwaj, A., Alkayed, N., Harder, D. R., Traystman, R. J. & Koehler, R. C., Jul 1 2002, In : International Congress Series. 1235, C, p. 289-295 7 p.

Research output: Contribution to journalArticle

Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors

Peng, X., Carhuapoma, J. R., Bhardwaj, A., Alkayed, N. J., Falck, J. R., Harder, D. R., Traystman, R. J. & Koehler, R. C., Nov 1 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 5 52-5, p. H2029-H2037

Research output: Contribution to journalArticle

92 Scopus citations
2001

Anesthetic choice of halothane versus propofol impact on experimental perioperative stroke

Bhardwaj, A., Castro, A. F., Alkayed, N. J., Hurn, P. D. & Kirsch, J. R., Jan 1 2001, In : Stroke. 32, 8, p. 1920-1925 6 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Estrogen and Bcl-2: Gene induction and effect of transgene in experimental stroke

Alkayed, N. J., Goto, S., Sugo, N., Joh, H. D., Klaus, J., Crain, B. J., Bernard, O., Traystman, R. J. & Hurn, P. D., Oct 1 2001, In : Journal of Neuroscience. 21, 19, p. 7543-7550 8 p.

Research output: Contribution to journalArticle

166 Scopus citations

Experimental stroke in the female diabetic, db/db, mouse

Vannucci, S. J., Willing, L. B., Goto, S., Alkayed, N. J., Brucklacher, R. M., Wood, T. L., Towfighi, J., Hurn, P. D. & Simpson, I. A., Jan 1 2001, In : Journal of Cerebral Blood Flow and Metabolism. 21, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

Open Access
118 Scopus citations

Gender-based differences in Na+-K+ adenosine triphosphatase activity occur in the microcirculation of the diabetic rat brain

Sieber, F. E., Hurn, P., Alkayed, N. J. & Traystman, R. J., Jan 1 2001, In : Anesthesiology. 94, 2, p. 372-375 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke

McCullough, L. D., Alkayed, N. J., Traystman, R. J., Williams, M. J. & Hurn, P. D., Jan 1 2001, In : Stroke. 32, 3, p. [d]796-802

Research output: Contribution to journalArticle

Open Access
165 Scopus citations

Social stress exacerbates stroke outcome by suppressing Bcl-2 expression

DeVries, A. C., Joh, H. D., Bernard, O., Hattori, K., Hurn, P. D., Traystman, R. J. & Alkayed, N. J., Sep 25 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 20, p. 11824-11828 5 p.

Research output: Contribution to journalArticle

121 Scopus citations
2000

Estrogen receptor antagonist ICI182,780 exacerbates ischemic injury in female mouse

Sawada, M., Alkayed, N. J., Goto, S., Grain, B. J., Traystman, R. J., Shaivitz, A., Nelson, R. J. & Hurn, P. D., Jan 1 2000, In : Journal of Cerebral Blood Flow and Metabolism. 20, 1, p. 112-118 7 p.

Research output: Contribution to journalArticle

Open Access
127 Scopus citations

Hypertonic saline worsens infarct volume after transient focal ischemia in rats

Bhardwaj, A., Harukuni, I., Murphy, S. J., Alkayed, N. J., Crain, B. J., Koehler, R. C., Hurn, P. D. & Traystman, R. J., Jul 2000, In : Stroke. 31, 7, p. 1694-1701 8 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

Is the acetazolamide test valid for quantitative assessment of maximal cerebral autoregulatory vasodilation? [5] (multiple letters)

Derdeyn, C. P. & Alkayed, N. J., Sep 30 2000, In : Stroke. 31, 9, p. 2271-2272 2 p.

Research output: Contribution to journalLetter

5 Scopus citations

Neuroprotective effects of female gonadal steroids in reproductively senescent female rats

Alkayed, N. J., Murphy, S. J., Traystman, R. J. & Hurn, P. D., Jan 2000, In : Stroke. 31, 1, p. 161-168 8 p.

Research output: Contribution to journalArticle

Open Access
294 Scopus citations

Stroke in estrogen receptor-α-deficient mice

Sampei, K., Goto, S., Alkayed, N. J., Crain, B. J., Korach, K. S., Traystman, R. J., Demas, G. E., Nelson, R. J. & Hurn, P. D., Mar 2000, In : Stroke. 31, 3, p. 738-744 7 p.

Research output: Contribution to journalArticle

Open Access
131 Scopus citations
1999

17β-Estradiol reduces stroke injury in estrogen-deficient female animals

Rusa, R., Alkayed, N. J., Crain, B. J., Traystman, R. J., Kimes, A. S., London, E. D., Klaus, J. A. & Hurn, P. D., Aug 1999, In : Stroke. 30, 8, p. 1665-1670 6 p.

Research output: Contribution to journalArticle

Open Access
267 Scopus citations

Heme oxygenase-2 is neuroprotective in cerebral ischemia

Doré, S., Sampei, K., Goto, S., Alkayed, N. J., Guastella, D., Blackshaw, S., Gallagher, M., Traystman, R. J., Hurn, P. D., Koehler, R. C. & Snyder, S. H., 1999, In : Molecular Medicine. 5, 10, p. 656-663 8 p.

Research output: Contribution to journalArticle

Open Access
131 Scopus citations
1998

Estrogen-enhanced expression of bcl-2 mRNA in rat brain after experimental stroke

Alkayed, N. J., McCune, S. K., Crain, B. J., Traystman, R. J. & Hurn, P. D., Mar 20 1998, In : FASEB Journal. 12, 5, p. A954

Research output: Contribution to journalArticle

8 Scopus citations

Functional hyperemia in the brain: Hypothesis for astrocyte-derived vasodilator metabolites

Harder, D. R., Alkayed, N. J., Lange, A. R., Gebremedhin, D. & Roman, R. J., Jan 1998, In : Stroke. 29, 1, p. 229-234 6 p.

Research output: Contribution to journalReview article

Open Access
176 Scopus citations

Gender-linked brain injury in experimental stroke

Alkayed, N. J., Harukuni, I., Kimes, A. S., London, E. D., Traystman, R. J. & Hurn, P. D., Jan 1998, In : Stroke. 29, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

Open Access
604 Scopus citations
1997

Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats

Alkayed, N. J., Birks, E. K., Narayanan, J., Petrie, K. A., Kohler-Cabot, A. E. & Harder, D. R., May 1997, In : Stroke. 28, 5, p. 1066-1072 7 p.

Research output: Contribution to journalArticle

111 Scopus citations
1996

Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow

Alkayed, N. J., Birks, E. K., Hudetz, A. G., Roman, R. J., Henderson, L. & Harder, D. R., Oct 1996, In : American Journal of Physiology - Heart and Circulatory Physiology. 271, 4 40-4, p. H1541-H1546

Research output: Contribution to journalArticle

93 Scopus citations

Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes

Alkayed, N. J., Narayanan, J., Gebremedhin, D., Medhora, M., Roman, R. J. & Harder, D. R., May 1996, In : Stroke. 27, 5, p. 971-979 9 p.

Research output: Contribution to journalArticle

160 Scopus citations
1994

Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats

Li, P., Zou, A. P., Aj-Kayed, N. J., Rusch, N. J. & Harder, D. R., Jun 1994, In : Hypertension. 23, 6, p. 912-918 7 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations