• 5882 Citations
  • 42 h-Index
19942019
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Research Output 1994 2019

  • 5882 Citations
  • 42 h-Index
  • 130 Article
  • 1 Chapter
  • 1 Review article
264 Citations (Scopus)

17β-Estradiol reduces stroke injury in estrogen-deficient female animals

Rusa, R., Alkayed, N., Crain, B. J., Traystman, R. J., Kimes, A. S., London, E. D., Klaus, J. A. & Hurn, P. D., Aug 1999, In : Stroke. 30, 8, p. 1665-1670 6 p.

Research output: Contribution to journalArticle

Estradiol
Estrogens
Stroke
Middle Cerebral Artery Infarction
Putamen
6 Citations (Scopus)

18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase

Horti, A. G., Wang, Y., Minn, I., Lan, X., Wang, J., Koehler, R. C., Alkayed, N., Dannals, R. F. & Pomper, M. G., Nov 1 2016, In : Journal of Nuclear Medicine. 57, 11, p. 1817-1822 6 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Papio
Brain
Knockout Mice
Radioactivity
20 Citations (Scopus)

Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma

Johnson, L. A., Zuloaga, K. L., Kugelman, T. L., Mader, K. S., Morré, J. T., Zuloaga, D. G., Weber, S., Marzulla, T., Mulford, A., Button, D., Lindner, J., Alkayed, N., Stevens, J. F. & Raber, J., Jan 1 2016, In : EBioMedicine. 3, p. 26-42 17 p.

Research output: Contribution to journalArticle

Dietary Fats
Nutrition
Plasmas
Data storage equipment
Medical problems
39 Citations (Scopus)

Anesthetic choice of halothane versus propofol impact on experimental perioperative stroke

Bhardwaj, A., Castro, A. F., Alkayed, N., Hurn, P. D. & Kirsch, J., 2001, In : Stroke. 32, 8, p. 1920-1925 6 p.

Research output: Contribution to journalArticle

Propofol
Halothane
Anesthetics
Stroke
Middle Cerebral Artery Infarction
18 Citations (Scopus)

A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A., Alkayed, N. & Offner, H., 2014, In : Metabolic Brain Disease. 29, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

HLA-DR1 Antigen
Brain
Middle Cerebral Artery Infarction
Stroke
Macrophage Migration-Inhibitory Factors
10 Citations (Scopus)

A novel mouse model of thromboembolic stroke

Chen, Y., Zhu, W., Zhang, W., Libal, N., Murphy, S. J., Offner, H. & Alkayed, N., Dec 30 2015, In : Journal of Neuroscience Methods. 256, p. 203-211 9 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
Stroke
Lasers
Thrombosis
Catheters
45 Citations (Scopus)

A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat

Iliff, J., Close, L. N., Selden, N. & Alkayed, N., Jul 2007, In : Experimental Physiology. 92, 4, p. 653-658 6 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Epoxide Hydrolases
Eicosanoids
Cytochrome P-450 Enzyme System
Acids
3 Citations (Scopus)

Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response

Johnson, L. A., Torres, E. R., Weber Boutros, S., Patel, E., Akinyeke, T., Alkayed, N. & Raber, J., Jan 1 2017, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Apolipoprotein E4
High Fat Diet
Meals
Insulin Resistance
Protein Isoforms
15 Citations (Scopus)

Automated segmentation and enhancement of optical coherence tomography-acquired images of rodent brain

Baran, U., Zhu, W., Choi, W. J., Omori, M., Zhang, W., Alkayed, N. & Wang, R. K., Sep 1 2016, In : Journal of Neuroscience Methods. 270, p. 132-137 6 p.

Research output: Contribution to journalArticle

Optical Coherence Tomography
Rodentia
Brain
Ophthalmology
Neurosciences
14 Citations (Scopus)

Brainstem control of cerebral blood flow and application to acute vasospasm following experimental subarachnoid hemorrhage

Cetas, J., Lee, D. R., Alkayed, N., Wang, R., Iliff, J. & Heinricher, M., Oct 6 2009, In : Neuroscience. 163, 2, p. 719-729 11 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Subarachnoid Hemorrhage
Brain Stem
Perfusion
Ischemia
59 Citations (Scopus)

CaMKKβ-Dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation

Zhou, X., Cao, Y., Ao, G., Hu, L., Liu, H., Wu, J., Wang, X., Jin, M., Zheng, S., Zhen, X., Alkayed, N., Jia, J. & Cheng, J., Oct 20 2014, In : Antioxidants and Redox Signaling. 21, 12, p. 1741-1758 18 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Calcium-Calmodulin-Dependent Protein Kinases
AMP-Activated Protein Kinases
Phosphotransferases
Chemical activation
15 Citations (Scopus)
Brain Ischemia
Genes
Reperfusion
Cerebrovascular Circulation
Arteries
20 Citations (Scopus)

Cocaine- and amphetamine-regulated transcript (CART) peptide: A vasoactive role in the cerebral circulation

Iliff, J., Alkayed, N., Gloshani, K. J., Traystman, R. J. & West, G. A., Oct 2005, In : Journal of Cerebral Blood Flow and Metabolism. 25, 10, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Amphetamine
Cocaine
Peptides
Arterioles

Comments

Alkayed, N., Jan 2009, In : Acta Neurochirurgica. 151, 12, p. 1692 1 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Coronary autoregulation is abnormal in syndrome X: Insights using myocardial contrast echocardiography

Rinkevich, D., Belcik, T., Gupta, N. C., Cannard, E., Alkayed, N. & Kaul, S., Mar 2013, In : Journal of the American Society of Echocardiography. 26, 3, p. 290-296 7 p.

Research output: Contribution to journalArticle

Echocardiography
Homeostasis
Dipyridamole
Eicosanoids
Gonadal Steroid Hormones
15 Citations (Scopus)
Response Elements
Cyclic AMP
Carrier Proteins
Phosphorylation
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
11 Citations (Scopus)

Cytochrome P450 eicosanoids in cerebrovascular function and disease

Davis, C., Liu, X. & Alkayed, N., 2017, (Accepted/In press) In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Cerebrovascular Disorders
Eicosanoids
Cytochrome P-450 Enzyme System
Wounds and Injuries
Brain Diseases
38 Citations (Scopus)

Cytochrome P450 in neurological disease

Liu, M., Hurn, P. D. & Alkayed, N., Jun 2004, In : Current Drug Metabolism. 5, 3, p. 225-234 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Brain
Neurotransmitter Agents
Cerebrovascular Circulation
Cholesterol
42 Citations (Scopus)

Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

Mao, L., Jia, J., Zhou, X., Xiao, Y., Wang, Y., Mao, X., Zhen, X., Guan, Y., Alkayed, N. & Cheng, J., Feb 2 2013, In : Neuroscience. 231, p. 272-281 10 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Stroke
Axons
Brain
Therapeutics
40 Citations (Scopus)

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. & Hurn, P. D., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Dihydrotestosterone
Wounds and Injuries
Middle Cerebral Artery Infarction
Genes
Reperfusion
32 Citations (Scopus)

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. & Hurn, P. D., Sep 7 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 9, p. 1553-1562 10 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Androgens
Wounds and Injuries
Brain Ischemia
Reperfusion
61 Citations (Scopus)

Dependency of Cortical Functional Hyperemia to Forepaw Stimulation on Epoxygenase and Nitric Oxide Synthase Activities in Rats

Peng, X., Zhang, C., Alkayed, N., Harder, D. R. & Koehler, R. C., May 2004, In : Journal of Cerebral Blood Flow and Metabolism. 24, 5, p. 509-517 9 p.

Research output: Contribution to journalArticle

Hyperemia
Nitric Oxide Synthase
Arginine
Miconazole
Astrocytes
15 Citations (Scopus)

Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats

Dziennis, S., Yang, D., Cheng, J., Anderson, K. A., Alkayed, N., Hurn, P. D. & Lein, P. J., Apr 2008, In : Environmental Health Perspectives. 116, 4, p. 474-480 7 p.

Research output: Contribution to journalArticle

Chlorodiphenyl (54% Chlorine)
Polychlorinated Biphenyls
Rats
PCB
Stroke
38 Citations (Scopus)

Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress

Jia, J., Xiao, Y., Wang, W., Qing, L., Xu, Y., Song, H., Zhen, X., Ao, G., Alkayed, N. & Cheng, J., Jun 2013, In : Neurochemistry International. 62, 8, p. 1072-1078 7 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Glutamic Acid
Oxidative Stress
AMP-Activated Protein Kinases
Glyburide
11 Citations (Scopus)
Stroke
Ligands
Therapeutics
Immunotherapy
Atrophy
4 Citations (Scopus)

Disrupting dimerization translocates soluble epoxide hydrolase to peroxisomes

Nelson, J. W., Das, A. J., Barnes, A. & Alkayed, N., May 1 2016, In : PLoS One. 11, 5, e0152742.

Research output: Contribution to journalArticle

epoxide hydrolase
Epoxide Hydrolases
Peroxisomes
dimerization
Dimerization
1 Citation (Scopus)
GTP-Binding Proteins
Neurotensin
Mutation
neurotensin (8-13)
Amino Acid Substitution
1 Citation (Scopus)
Electrosurgery
Patient Positioning
Implantable Defibrillators
Electromagnetic Phenomena
Umbilicus
102 Citations (Scopus)

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice

Lee, C. R., Imig, J. D., Edin, M. L., Foley, J., DeGraff, L. M., Bradbury, J. A., Graves, J. P., Lih, F. B., Clark, J., Myers, P., Perrow, A. L., Lepp, A. N., Kannon, M. A., Ronnekleiv, O., Alkayed, N., Falck, J. R., Tomer, K. B. & Zeldin, D. C., 2010, In : FASEB Journal. 24, 10, p. 3770-3781 12 p.

Research output: Contribution to journalArticle

Renal Hypertension
Blood pressure
Cytochrome P-450 Enzyme System
Transgenic Mice
Blood Pressure
7 Citations (Scopus)

Endothelium-derived hyperpolarizing factor in the brain: Influence of sex, vessel size and disease state

Davis, C., Siler, D. A. & Alkayed, N., May 2011, In : Women's Health. 7, 3, p. 293-303 11 p.

Research output: Contribution to journalArticle

Vascular Diseases
Endothelium
Blood Vessels
Stroke
Tunica Intima
52 Citations (Scopus)
Epoxide Hydrolases
Cerebrovascular Circulation
Vasodilation
Ganglia
Trigeminal Ganglion
78 Citations (Scopus)

Epoxyeicosanoid signaling in CNS function and disease

Iliff, J., Jia, J., Nelson, J., Goyagi, T., Klaus, J. & Alkayed, N., Apr 2010, In : Prostaglandins and Other Lipid Mediators. 91, 3-4, p. 68-84 17 p.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Neurology
Central Nervous System
Brain Ischemia
Cytochrome P-450 Enzyme System
20 Citations (Scopus)

Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons

Iliff, J., Fairbanks, S. L., Balkowiec, A. & Alkayed, N., Dec 2010, In : Journal of Neurochemistry. 115, 6, p. 1530-1542 13 p.

Research output: Contribution to journalArticle

Trigeminal Ganglion
Calcitonin Gene-Related Peptide
Neuropeptides
Neurons
Acids
29 Citations (Scopus)

Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures

Abdu, E., Bruun, D. A., Yang, D., Yang, J., Inceoglu, B., Hammock, B. D., Alkayed, N. & Lein, P. J., May 2011, In : Journal of Neurochemistry. 117, 4, p. 632-642 11 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Cell culture
Neurons
Cell Culture Techniques
Sensory Receptor Cells
12 Citations (Scopus)

Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume

Shim, C. Y., Kim, S., Chadderdon, S., Wu, M., Yue, Q., Xie, A., Alkayed, N., Davidson, B. P. & Lindner, J., Dec 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 12, p. E1097-E1104

Research output: Contribution to journalArticle

8,11,14-Eicosatrienoic Acid
Epoxide Hydrolases
Benzoates
Regional Blood Flow
Hyperinsulinism

Erratum: Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion (Journal of Neurochemistry (2012) 121 (680-692)

Di Domenico, F., Casalena, G., Jia, J., Sultana, R., Barone, E., Cai, J., Pierce, W. M., Cini, C., Mancuso, C., Perluigi, M., Davis, C., Alkayed, N. & Butterfield, A. D., Sep 2012, In : Journal of Neurochemistry. 122, 5, p. 1093 1 p.

Research output: Contribution to journalArticle

Neurochemistry
Proteome
Brain Ischemia
Sex Characteristics
Reperfusion

Erratum to: A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A., Alkayed, N. & Offner, H., 2014, (Accepted/In press) In : Metabolic Brain Disease. p. 1 1 p.

Research output: Contribution to journalArticle

Brain
15 Citations (Scopus)

Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA

Joh, H. D., Searles, R. V., Selmanoff, M., Alkayed, N., Koehler, R. C., Hurn, P. D. & Murphy, S. J., Apr 2006, In : Journal of Cerebral Blood Flow and Metabolism. 26, 4, p. 518-526 9 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Estradiol
Messenger RNA
Brain
Middle Cerebral Artery Infarction
Estradiol
Middle Cerebral Artery Infarction
Brain
Estrogens
Brain Ischemia
166 Citations (Scopus)

Estrogen and Bcl-2: Gene induction and effect of transgene in experimental stroke

Alkayed, N., Goto, S., Sugo, N., Joh, H. D., Klaus, J., Crain, B. J., Bernard, O., Traystman, R. J. & Hurn, P. D., Oct 1 2001, In : Journal of Neuroscience. 21, 19, p. 7543-7550 8 p.

Research output: Contribution to journalArticle

bcl-2 Genes
Transgenes
Estrogens
Stroke
Ovariectomy
8 Citations (Scopus)

Estrogen-enhanced expression of bcl-2 mRNA in rat brain after experimental stroke

Alkayed, N., McCune, S. K., Crain, B. J., Traystman, R. J. & Hurn, P. D., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

stroke
estrogens
Rats
Brain
Estrogens

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Yang, Z., Wang, L., Hua, Z., Hurn, P. D., Alkayed, N. & Xu, Y., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Estradiol
Estrogens
Stroke
Apoptosis
anti-Fas monoclonal antibody
46 Citations (Scopus)

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Guan, D., Zhu, W., Alkayed, N., Wang, M. M., Hua, Z. & Xu, Y., Jan 2009, In : Experimental Neurology. 215, 1, p. 48-52 5 p.

Research output: Contribution to journalArticle

Estradiol
Estrogens
Brain Ischemia
Stroke
Apoptosis
9 Citations (Scopus)

Estrogen-mediated renoprotection following cardiac arrest and cardiopulmonary resuscitation is robust to GPR30 gene deletion

Hutchens, M., Kosaka, Y., Zhang, W., Fujiyoshi, T., Murphy, S., Alkayed, N. & Anderson, S., Jun 12 2014, In : PLoS One. 9, 6, e99910.

Research output: Contribution to journalArticle

cardiopulmonary resuscitation
Resuscitation
cardiac arrest
gene deletion
Cardiopulmonary Resuscitation
127 Citations (Scopus)

Estrogen receptor antagonist ICI182,780 exacerbates ischemic injury in female mouse

Sawada, M., Alkayed, N., Goto, S., Grain, B. J., Traystman, R. J., Shaivitz, A., Nelson, R. J. & Hurn, P. D., 2000, In : Journal of Cerebral Blood Flow and Metabolism. 20, 1, p. 112-118 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Wounds and Injuries
Estrogens
Brain
Corpus Striatum
111 Citations (Scopus)

Experimental stroke in the female diabetic, db/db, mouse

Vannucci, S. J., Willing, L. B., Goto, S., Alkayed, N., Brucklacher, R. M., Wood, T. L., Towfighi, J., Hurn, P. D. & Simpson, I. A., 2001, In : Journal of Cerebral Blood Flow and Metabolism. 21, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

Stroke
Cerebrovascular Circulation
Common Carotid Artery
Brain
Ligation
174 Citations (Scopus)

Functional hyperemia in the brain: Hypothesis for astrocyte-derived vasodilator metabolites

Harder, D. R., Alkayed, N., Lange, A. R., Gebremedhin, D. & Roman, R. J., Jan 1998, In : Stroke. 29, 1, p. 229-234 6 p.

Research output: Contribution to journalArticle

Hyperemia
Vasodilator Agents
Astrocytes
Glutamate Receptors
Brain
11 Citations (Scopus)

Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid

Liu, X., Qian, Z. Y., Xie, F., Fan, W., Nelson, J. W., Xiao, X., Kaul, S., Barnes, A. & Alkayed, N., Apr 28 2016, (Accepted/In press) In : Prostaglandins and Other Lipid Mediators.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Screening
Cardiovascular Physiological Phenomena
Prostaglandin Receptors
Physiology
8 Citations (Scopus)

Gender-based differences in Na +-K + adenosine triphosphatase activity occur in the microcirculation of the diabetic rat brain

Sieber, F. E., Hurn, P., Alkayed, N. & Traystman, R. J., 2001, In : Anesthesiology. 94, 2, p. 372-375 4 p.

Research output: Contribution to journalArticle

Inbred BB Rats
Sodium-Potassium-Exchanging ATPase
Microcirculation
Sex Characteristics
Protein Kinase C
589 Citations (Scopus)

Gender-linked brain injury in experimental stroke

Alkayed, N., Harukuni, I., Kimes, A. S., London, E. D., Traystman, R. J. & Hurn, P. D., Jan 1998, In : Stroke. 29, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Brain Injuries
Stroke
Ischemia
Laser-Doppler Flowmetry