• 6066 Citations
  • 43 h-Index
1994 …2020

Research output per year

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Research Output

1994

Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats

Li, P., Zou, A. P., Aj-Kayed, N. J., Rusch, N. J. & Harder, D. R., Jun 1994, In : Hypertension. 23, 6, p. 912-918 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
1996

Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow

Alkayed, N. J., Birks, E. K., Hudetz, A. G., Roman, R. J., Henderson, L. & Harder, D. R., Oct 1 1996, In : American Journal of Physiology - Heart and Circulatory Physiology. 271, 4 40-4, p. H1541-H1546

Research output: Contribution to journalArticle

93 Scopus citations

Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes

Alkayed, N. J., Narayanan, J., Gebremedhin, D., Medhora, M., Roman, R. J. & Harder, D. R., May 1996, In : Stroke. 27, 5, p. 971-979 9 p.

Research output: Contribution to journalArticle

160 Scopus citations
1997

Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats

Alkayed, N. J., Birks, E. K., Narayanan, J., Petrie, K. A., Kohler-Cabot, A. E. & Harder, D. R., May 1997, In : Stroke. 28, 5, p. 1066-1072 7 p.

Research output: Contribution to journalArticle

111 Scopus citations
1998

Estrogen-enhanced expression of bcl-2 mRNA in rat brain after experimental stroke

Alkayed, N. J., McCune, S. K., Crain, B. J., Traystman, R. J. & Hurn, P. D., Mar 20 1998, In : FASEB Journal. 12, 5, p. A954

Research output: Contribution to journalArticle

8 Scopus citations

Functional hyperemia in the brain: Hypothesis for astrocyte-derived vasodilator metabolites

Harder, D. R., Alkayed, N. J., Lange, A. R., Gebremedhin, D. & Roman, R. J., Jan 1998, In : Stroke. 29, 1, p. 229-234 6 p.

Research output: Contribution to journalReview article

Open Access
176 Scopus citations

Gender-linked brain injury in experimental stroke

Alkayed, N. J., Harukuni, I., Kimes, A. S., London, E. D., Traystman, R. J. & Hurn, P. D., Jan 1998, In : Stroke. 29, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

Open Access
599 Scopus citations
1999

17β-Estradiol reduces stroke injury in estrogen-deficient female animals

Rusa, R., Alkayed, N. J., Crain, B. J., Traystman, R. J., Kimes, A. S., London, E. D., Klaus, J. A. & Hurn, P. D., Aug 1999, In : Stroke. 30, 8, p. 1665-1670 6 p.

Research output: Contribution to journalArticle

Open Access
266 Scopus citations

Heme oxygenase-2 is neuroprotective in cerebral ischemia

Doré, S., Sampei, K., Goto, S., Alkayed, N. J., Guastella, D., Blackshaw, S., Gallagher, M., Traystman, R. J., Hurn, P. D., Koehler, R. C. & Snyder, S. H., Dec 1 1999, In : Molecular Medicine. 5, 10, p. 656-663 8 p.

Research output: Contribution to journalArticle

131 Scopus citations
2000

Estrogen receptor antagonist ICI182,780 exacerbates ischemic injury in female mouse

Sawada, M., Alkayed, N. J., Goto, S., Grain, B. J., Traystman, R. J., Shaivitz, A., Nelson, R. J. & Hurn, P. D., Jan 1 2000, In : Journal of Cerebral Blood Flow and Metabolism. 20, 1, p. 112-118 7 p.

Research output: Contribution to journalArticle

Open Access
127 Scopus citations

Hypertonic saline worsens infarct volume after transient focal ischemia in rats

Bhardwaj, A., Harukuni, I., Murphy, S. J., Alkayed, N. J., Crain, B. J., Koehler, R. C., Hurn, P. D. & Traystman, R. J., Jul 2000, In : Stroke. 31, 7, p. 1694-1701 8 p.

Research output: Contribution to journalArticle

Open Access
57 Scopus citations

Is the acetazolamide test valid for quantitative assessment of maximal cerebral autoregulatory vasodilation? [5] (multiple letters)

Derdeyn, C. P. & Alkayed, N. J., Sep 30 2000, In : Stroke. 31, 9, p. 2271-2272 2 p.

Research output: Contribution to journalLetter

5 Scopus citations

Neuroprotective effects of female gonadal steroids in reproductively senescent female rats

Alkayed, N. J., Murphy, S. J., Traystman, R. J. & Hurn, P. D., Jan 2000, In : Stroke. 31, 1, p. 161-168 8 p.

Research output: Contribution to journalArticle

Open Access
293 Scopus citations

Stroke in estrogen receptor-α-deficient mice

Sampei, K., Goto, S., Alkayed, N. J., Crain, B. J., Korach, K. S., Traystman, R. J., Demas, G. E., Nelson, R. J. & Hurn, P. D., Mar 2000, In : Stroke. 31, 3, p. 738-744 7 p.

Research output: Contribution to journalArticle

Open Access
131 Scopus citations
2001

Anesthetic choice of halothane versus propofol impact on experimental perioperative stroke

Bhardwaj, A., Castro, A. F., Alkayed, N. J., Hurn, P. D. & Kirsch, J. R., Jan 1 2001, In : Stroke. 32, 8, p. 1920-1925 6 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Estrogen and Bcl-2: Gene induction and effect of transgene in experimental stroke

Alkayed, N. J., Goto, S., Sugo, N., Joh, H. D., Klaus, J., Crain, B. J., Bernard, O., Traystman, R. J. & Hurn, P. D., Oct 1 2001, In : Journal of Neuroscience. 21, 19, p. 7543-7550 8 p.

Research output: Contribution to journalArticle

166 Scopus citations

Experimental stroke in the female diabetic, db/db, mouse

Vannucci, S. J., Willing, L. B., Goto, S., Alkayed, N. J., Brucklacher, R. M., Wood, T. L., Towfighi, J., Hurn, P. D. & Simpson, I. A., Jan 1 2001, In : Journal of Cerebral Blood Flow and Metabolism. 21, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

Open Access
115 Scopus citations

Gender-based differences in Na+-K+ adenosine triphosphatase activity occur in the microcirculation of the diabetic rat brain

Sieber, F. E., Hurn, P., Alkayed, N. J. & Traystman, R. J., Jan 1 2001, In : Anesthesiology. 94, 2, p. 372-375 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke

McCullough, L. D., Alkayed, N. J., Traystman, R. J., Williams, M. J. & Hurn, P. D., Jan 1 2001, In : Stroke. 32, 3, p. [d]796-802

Research output: Contribution to journalArticle

Open Access
164 Scopus citations

Social stress exacerbates stroke outcome by suppressing Bcl-2 expression

DeVries, A. C., Joh, H. D., Bernard, O., Hattori, K., Hurn, P. D., Traystman, R. J. & Alkayed, N. J., Sep 25 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 20, p. 11824-11828 5 p.

Research output: Contribution to journalArticle

120 Scopus citations
2002

Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack

Alkayed, N. J., Goyagi, T., Joh, H. D., Klaus, J., Harder, D. R., Traystman, R. J. & Hurn, P. D., Jun 22 2002, In : Stroke. 33, 6, p. 1677-1684 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Regulation of the cerebral circulation by cytochrome P450 epoxygenase activity

Peng, X., Carhuapoma, J. R., Bhardwaj, A., Alkayed, N., Harder, D. R., Traystman, R. J. & Koehler, R. C., Jul 1 2002, In : International Congress Series. 1235, C, p. 289-295 7 p.

Research output: Contribution to journalArticle

Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors

Peng, X., Carhuapoma, J. R., Bhardwaj, A., Alkayed, N. J., Falck, J. R., Harder, D. R., Traystman, R. J. & Koehler, R. C., Nov 1 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 5 52-5, p. H2029-H2037

Research output: Contribution to journalArticle

91 Scopus citations
2003

Characterization of a new double-filament model of focal cerebral ischemia in heme oxygenase-2-deficient mice

Goto, S., Sampei, K., Alkayed, N. J., Doré, S. & Koehler, R. C., Jul 1 2003, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 285, 1 54-1, p. R222-R230

Research output: Contribution to journalArticle

15 Scopus citations

High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats

Antezana, D. F., Clatterbuck, R. E., Alkayed, N. J., Murphy, S. J., Anderson, L. G., Frazier, J., Hurn, P. D., Traystman, R. J. & Tamargo, R. J., Apr 1 2003, In : Journal of neurosurgery. 98, 4, p. 860-866 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Mechanisms of ischemic brain damage

Bhardwaj, A., Alkayed, N. J., Kirsch, J. R. & Hurn, P. D., Mar 2003, In : Current cardiology reports. 5, 2, p. 160-167 8 p.

Research output: Contribution to journalReview article

30 Scopus citations
2004

Cytochrome P450 in neurological disease

Liu, M., Hurn, P. D. & Alkayed, N. J., Jun 1 2004, In : Current Drug Metabolism. 5, 3, p. 225-234 10 p.

Research output: Contribution to journalReview article

38 Scopus citations

Dependency of Cortical Functional Hyperemia to Forepaw Stimulation on Epoxygenase and Nitric Oxide Synthase Activities in Rats

Peng, X., Zhang, C., Alkayed, N. J., Harder, D. R. & Koehler, R. C., May 2004, In : Journal of Cerebral Blood Flow and Metabolism. 24, 5, p. 509-517 9 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations
2005

Cocaine- and amphetamine-regulated transcript (CART) peptide: A vasoactive role in the cerebral circulation

Iliff, J. J., Alkayed, N. J., Gloshani, K. J., Traystman, R. J. & West, G. A., Oct 1 2005, In : Journal of Cerebral Blood Flow and Metabolism. 25, 10, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
74 Scopus citations
2006

Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA

Joh, H. D., Searles, R. V., Selmanoff, M., Alkayed, N. J., Koehler, R. C., Hurn, P. D. & Murphy, S. J., Apr 1 2006, In : Journal of Cerebral Blood Flow and Metabolism. 26, 4, p. 518-526 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection

Xu, Y., Zhang, W., Klaus, J., Young, J., Koerner, I., Sheldahl, L. C., Hurn, P. D., Martínez-Murillo, F. & Alkayed, N. J., Sep 26 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 39, p. 14489-14494 6 p.

Research output: Contribution to journalArticle

96 Scopus citations
2007

A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat

Iliff, J. J., Close, L. N., Selden, N. R. & Alkayed, N. J., Jul 2007, In : Experimental physiology. 92, 4, p. 653-658 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. J. & Hurn, P. D., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BO11-06

Research output: Contribution to journalArticle

39 Scopus citations

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. J. & Hurn, P. D., Sep 7 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 9, p. 1553-1562 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Estradiol is protective against ischemic brain damage through signal trasducer and activator of transcription 3 (STAT3)

Dziennis, S., Jia, T., Ronnekleiv, O. K., Hurn, P. D. & Alkayed, N. J., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BP8-03U

Research output: Contribution to journalArticle

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Yang, Z., Wang, L., Hua, Z., Hurn, P. D., Alkayed, N. J. & Xu, Y., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BP43-01H

Research output: Contribution to journalArticle

Mitochondrial mechanism of neuroprotection by CART

Mao, P., Ardeshiri, A., Jacks, R., Yang, S., Hurn, P. D. & Alkayed, N. J., Aug 1 2007, In : European Journal of Neuroscience. 26, 3, p. 624-632 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury

Koerner, I. P., Jacks, R., DeBarber, A. E., Koop, D., Mao, P., Grant, D. F. & Alkayed, N. J., Apr 25 2007, In : Journal of Neuroscience. 27, 17, p. 4642-4649 8 p.

Research output: Contribution to journalArticle

92 Scopus citations

Role of MAPK in neuroprotection by cart in ischemic stroke

Xu, Y., Jia, J., Hua, Z., Hurn, P. & Alkayed, N. J., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BO06-01

Research output: Contribution to journalArticle

Role of P450 aromatase in sex-specific astrocytic cell death

Liu, M., Hurn, P. D., Roselli, C. E. & Alkayed, N. J., Jan 5 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 1, p. 135-141 7 p.

Research output: Contribution to journalArticle

99 Scopus citations

Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection

Dziennis, S., Jia, T., Rønnekleiv, O. K., Hurn, P. D. & Alkayed, N. J., Jul 4 2007, In : Journal of Neuroscience. 27, 27, p. 7268-7274 7 p.

Research output: Contribution to journalArticle

80 Scopus citations

Sex-specific anti-oxidant capacities in astrocytes

Liu, M., Alkayed, N. J., Oyarzabal, E. & Hurn, P. D., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BP8-02U

Research output: Contribution to journalArticle

Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2

Yang, S., Bhardwaj, A., Cheng, J., Alkayed, N. J., Hurn, P. D. & Kirsch, J. R., May 1 2007, In : Anesthesia and analgesia. 104, 5, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Soluble epoxide hydrolase: Sex differences and role in estrogen-mediated neuroprotection

Zhang, W., Iliff, J. J., Alhadid, Y. K., Ardeshiri, A., Koerner, I. P., Hurn, P. D. & Alkayed, N. J., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BP37-03H

Research output: Contribution to journalArticle

Soluble epoxide hydrolase: A novel therapeutic target in stroke

Zhang, W., Koerner, I. P., Noppens, R., Grafe, M., Tsai, H. J., Morisseau, C., Luria, A., Hammock, B. D., Falck, J. R. & Alkayed, N. J., Dec 1 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 12, p. 1931-1940 10 p.

Research output: Contribution to journalArticle

147 Scopus citations
2008

Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats

Dziennis, S., Yang, D., Cheng, J., Anderson, K. A., Alkayed, N. J., Hurn, P. D. & Lein, P. J., Apr 1 2008, In : Environmental health perspectives. 116, 4, p. 474-480 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

In vivo cerebrovascular effects of cocaine- and amphetamine-regulated transcript (CART) peptide

Iliff, J. J., Alkayed, N. J., Golshani, K. J., Weinstein, J., Traystman, R. J. & West, G. A., Jul 1 2008, In : Journal of Cardiovascular Pharmacology. 52, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Lack of sex-linked differences in cerebral edema and aquaporin-4 expression after experimental stroke

Liu, X., Zhang, W., Alkayed, N. J., Froehner, S. C., Adams, M. E., Amiry-Moghaddam, M., Ottersen, O. P., Hurn, P. D. & Bhardwaj, A., Dec 1 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 12, p. 1898-1906 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Role of Signal Transducer and activator of transcription 3 in neuronal survival and regeneration

Dziennis, S. & Alkayed, N. J., Jan 1 2008, In : Reviews in the Neurosciences. 19, 4-5, p. 341-361 21 p.

Research output: Contribution to journalReview article

96 Scopus citations