• 5882 Citations
  • 42 h-Index
19942019
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Research Output 1994 2019

  • 5882 Citations
  • 42 h-Index
  • 130 Article
  • 1 Chapter
  • 1 Review article
1994
23 Citations (Scopus)

Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats

Li, P., Zou, A. P., Alkayed, N., Rusch, N. J. & Harder, D. R., 1994, In : Hypertension. 23, 6, p. 912-918 7 p.

Research output: Contribution to journalArticle

Guanine Nucleotides
Smooth Muscle
Carrier Proteins
GTP-Binding Proteins
Aortic Coarctation
1996
92 Citations (Scopus)

Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow

Alkayed, N., Birks, E. K., Hudetz, A. G., Roman, R. J., Henderson, L. & Harder, D. R., Oct 1996, In : American Journal of Physiology - Heart and Circulatory Physiology. 40, 4

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Miconazole
Arachidonic Acid
Astrocytes
Brain

Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow

Alkayed, N., Birks, E. K., Hudetz, A. G., Roman, R. J., Henderson, L. & Harder, D. R., Oct 1996, In : American Journal of Physiology - Heart and Circulatory Physiology. 271, 4 40-4

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Miconazole
Arachidonic Acid
Astrocytes
Brain
160 Citations (Scopus)

Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes

Alkayed, N., Narayanan, J., Gebremedhin, D., Medhora, M., Roman, R. J. & Harder, D. R., May 1996, In : Stroke. 27, 5, p. 971-979 9 p.

Research output: Contribution to journalArticle

Astrocytes
Brain
Arachidonic Acid
Microcirculation
Microvessels
1997
110 Citations (Scopus)

Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats

Alkayed, N., Birks, E. K., Narayanan, J., Petrie, K. A., Kohler-Cabot, A. E. & Harder, D. R., May 1997, In : Stroke. 28, 5, p. 1066-1072 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Astrocytes
Glutamic Acid
Arachidonic Acid
Miconazole
1998
8 Citations (Scopus)

Estrogen-enhanced expression of bcl-2 mRNA in rat brain after experimental stroke

Alkayed, N., McCune, S. K., Crain, B. J., Traystman, R. J. & Hurn, P. D., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

stroke
estrogens
Rats
Brain
Estrogens
174 Citations (Scopus)

Functional hyperemia in the brain: Hypothesis for astrocyte-derived vasodilator metabolites

Harder, D. R., Alkayed, N., Lange, A. R., Gebremedhin, D. & Roman, R. J., Jan 1998, In : Stroke. 29, 1, p. 229-234 6 p.

Research output: Contribution to journalArticle

Hyperemia
Vasodilator Agents
Astrocytes
Glutamate Receptors
Brain
589 Citations (Scopus)

Gender-linked brain injury in experimental stroke

Alkayed, N., Harukuni, I., Kimes, A. S., London, E. D., Traystman, R. J. & Hurn, P. D., Jan 1998, In : Stroke. 29, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Brain Injuries
Stroke
Ischemia
Laser-Doppler Flowmetry
1999
264 Citations (Scopus)

17β-Estradiol reduces stroke injury in estrogen-deficient female animals

Rusa, R., Alkayed, N., Crain, B. J., Traystman, R. J., Kimes, A. S., London, E. D., Klaus, J. A. & Hurn, P. D., Aug 1999, In : Stroke. 30, 8, p. 1665-1670 6 p.

Research output: Contribution to journalArticle

Estradiol
Estrogens
Stroke
Middle Cerebral Artery Infarction
Putamen
127 Citations (Scopus)

Heme oxygenase-2 is neuroprotective in cerebral ischemia

Doré, S., Sampei, K., Goto, S., Alkayed, N., Guastella, D., Blackshaw, S., Gallagher, M., Traystman, R. J., Hurn, P. D., Koehler, R. C. & Snyder, S. H., 1999, In : Molecular Medicine. 5, 10, p. 656-663 8 p.

Research output: Contribution to journalArticle

Brain Ischemia
Bilirubin
Heme
Brain
Stroke
2000
127 Citations (Scopus)

Estrogen receptor antagonist ICI182,780 exacerbates ischemic injury in female mouse

Sawada, M., Alkayed, N., Goto, S., Grain, B. J., Traystman, R. J., Shaivitz, A., Nelson, R. J. & Hurn, P. D., 2000, In : Journal of Cerebral Blood Flow and Metabolism. 20, 1, p. 112-118 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Wounds and Injuries
Estrogens
Brain
Corpus Striatum
57 Citations (Scopus)

Hypertonic saline worsens infarct volume after transient focal ischemia in rats

Bhardwaj, A., Harukuni, I., Murphy, S. J., Alkayed, N., Crain, B. J., Koehler, R. C., Hurn, P. D. & Traystman, R. J., Jul 2000, In : Stroke. 31, 7, p. 1694-1701 8 p.

Research output: Contribution to journalArticle

Reperfusion
Ischemia
Cerebrovascular Circulation
Middle Cerebral Artery Infarction
Transient Ischemic Attack
5 Citations (Scopus)

Is the acetazolamide test valid for quantitative assessment of maximal cerebral autoregulatory vasodilation? [5] (multiple letters)

Derdeyn, C. P. & Alkayed, N., 2000, In : Stroke. 31, 9, p. 2271-2272 2 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Carbonic Anhydrase Inhibitors
Acetazolamide
Cerebral Arteries
Blood Flow Velocity
290 Citations (Scopus)

Neuroprotective effects of female gonadal steroids in reproductively senescent female rats

Alkayed, N., Murphy, S. J., Traystman, R. J. & Hurn, P. D., Jan 2000, In : Stroke. 31, 1, p. 161-168 8 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Steroids
Progesterone
Brain Injuries
Cerebrovascular Circulation
131 Citations (Scopus)

Stroke in estrogen receptor-α-deficient mice

Sampei, K., Goto, S., Alkayed, N., Crain, B. J., Korach, K. S., Traystman, R. J., Demas, G. E., Nelson, R. J. & Hurn, P. D., Mar 2000, In : Stroke. 31, 3, p. 738-744 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Stroke
Infarction
Middle Cerebral Artery Infarction
Cerebrovascular Circulation
2001
39 Citations (Scopus)

Anesthetic choice of halothane versus propofol impact on experimental perioperative stroke

Bhardwaj, A., Castro, A. F., Alkayed, N., Hurn, P. D. & Kirsch, J., 2001, In : Stroke. 32, 8, p. 1920-1925 6 p.

Research output: Contribution to journalArticle

Propofol
Halothane
Anesthetics
Stroke
Middle Cerebral Artery Infarction
166 Citations (Scopus)

Estrogen and Bcl-2: Gene induction and effect of transgene in experimental stroke

Alkayed, N., Goto, S., Sugo, N., Joh, H. D., Klaus, J., Crain, B. J., Bernard, O., Traystman, R. J. & Hurn, P. D., Oct 1 2001, In : Journal of Neuroscience. 21, 19, p. 7543-7550 8 p.

Research output: Contribution to journalArticle

bcl-2 Genes
Transgenes
Estrogens
Stroke
Ovariectomy
111 Citations (Scopus)

Experimental stroke in the female diabetic, db/db, mouse

Vannucci, S. J., Willing, L. B., Goto, S., Alkayed, N., Brucklacher, R. M., Wood, T. L., Towfighi, J., Hurn, P. D. & Simpson, I. A., 2001, In : Journal of Cerebral Blood Flow and Metabolism. 21, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

Stroke
Cerebrovascular Circulation
Common Carotid Artery
Brain
Ligation
8 Citations (Scopus)

Gender-based differences in Na +-K + adenosine triphosphatase activity occur in the microcirculation of the diabetic rat brain

Sieber, F. E., Hurn, P., Alkayed, N. & Traystman, R. J., 2001, In : Anesthesiology. 94, 2, p. 372-375 4 p.

Research output: Contribution to journalArticle

Inbred BB Rats
Sodium-Potassium-Exchanging ATPase
Microcirculation
Sex Characteristics
Protein Kinase C
164 Citations (Scopus)

Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke

McCullough, L. D., Alkayed, N., Traystman, R. J., Williams, M. J. & Hurn, P. D., 2001, In : Stroke. 32, 3

Research output: Contribution to journalArticle

Estrogens
Ischemia
Stroke
Cerebrovascular Circulation
Reperfusion
118 Citations (Scopus)

Social stress exacerbates stroke outcome by suppressing Bcl-2 expression

DeVries, A. C., Joh, H. D., Bernard, O., Hattori, K., Hurn, P. D., Traystman, R. J. & Alkayed, N., Sep 25 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 20, p. 11824-11828 5 p.

Research output: Contribution to journalArticle

Stroke
Corticosterone
Psychological Stress
Transgenic Mice
Cerebral Arteries
2002
89 Citations (Scopus)

Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack

Alkayed, N., Goyagi, T., Joh, H. D., Klaus, J., Harder, D. R., Traystman, R. J. & Hurn, P. D., 2002, In : Stroke. 33, 6, p. 1677-1684 8 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Up-Regulation
Cerebrovascular Circulation
Middle Cerebral Artery Infarction
Stroke

Regulation of the cerebral circulation by cytochrome P450 epoxygenase activity

Peng, X., Carhuapoma, J. R., Bhardwaj, A., Alkayed, N., Harder, D. R., Traystman, R. J. & Koehler, R. C., Jul 1 2002, In : International Congress Series. 1235, C, p. 289-295 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Vibrissae
Cytochrome P-450 Enzyme System
Miconazole
Microdialysis
88 Citations (Scopus)

Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors

Peng, X., Carhuapoma, J. R., Bhardwaj, A., Alkayed, N., Falck, J. R., Harder, D. R., Traystman, R. J. & Koehler, R. C., Nov 1 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 5 52-5

Research output: Contribution to journalArticle

Vibrissae
Hyperemia
Miconazole
Glutamic Acid
Chloralose
2003
15 Citations (Scopus)
Brain Ischemia
Genes
Reperfusion
Cerebrovascular Circulation
Arteries
41 Citations (Scopus)

High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats

Antezana, D. F., Clatterbuck, R. E., Alkayed, N., Murphy, S. J., Anderson, L. G., Frazier, J., Hurn, P. D., Traystman, R. J. & Tamargo, R. J., Apr 1 2003, In : Journal of Neurosurgery. 98, 4, p. 860-866 7 p.

Research output: Contribution to journalArticle

Corpus Striatum
Ibuprofen
Middle Cerebral Artery Infarction
Intercellular Adhesion Molecule-1
Cerebrovascular Circulation
30 Citations (Scopus)

Mechanisms of ischemic brain damage

Bhardwaj, A., Alkayed, N., Kirsch, J. & Hurn, P. D., Mar 2003, In : Current Cardiology Reports. 5, 2, p. 160-167 8 p.

Research output: Contribution to journalArticle

Brain Ischemia
Brain
Perioperative Period
Heart Arrest
Brain Injuries
2004
38 Citations (Scopus)

Cytochrome P450 in neurological disease

Liu, M., Hurn, P. D. & Alkayed, N., Jun 2004, In : Current Drug Metabolism. 5, 3, p. 225-234 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Brain
Neurotransmitter Agents
Cerebrovascular Circulation
Cholesterol
61 Citations (Scopus)

Dependency of Cortical Functional Hyperemia to Forepaw Stimulation on Epoxygenase and Nitric Oxide Synthase Activities in Rats

Peng, X., Zhang, C., Alkayed, N., Harder, D. R. & Koehler, R. C., May 2004, In : Journal of Cerebral Blood Flow and Metabolism. 24, 5, p. 509-517 9 p.

Research output: Contribution to journalArticle

Hyperemia
Nitric Oxide Synthase
Arginine
Miconazole
Astrocytes
2005
20 Citations (Scopus)

Cocaine- and amphetamine-regulated transcript (CART) peptide: A vasoactive role in the cerebral circulation

Iliff, J., Alkayed, N., Gloshani, K. J., Traystman, R. J. & West, G. A., Oct 2005, In : Journal of Cerebral Blood Flow and Metabolism. 25, 10, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Amphetamine
Cocaine
Peptides
Arterioles
74 Citations (Scopus)
Hypoxia-Inducible Factor 1
Astrocytes
Ischemic Preconditioning
Electrophoretic Mobility Shift Assay
Cytochrome P-450 Enzyme System
2006
15 Citations (Scopus)

Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA

Joh, H. D., Searles, R. V., Selmanoff, M., Alkayed, N., Koehler, R. C., Hurn, P. D. & Murphy, S. J., Apr 2006, In : Journal of Cerebral Blood Flow and Metabolism. 26, 4, p. 518-526 9 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Estradiol
Messenger RNA
Brain
Middle Cerebral Artery Infarction
94 Citations (Scopus)

Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection

Xu, Y., Zhang, W., Klaus, J., Young, J., Koerner, I., Sheldahl, L. C., Hurn, P. D., Martínez-Murillo, F. & Alkayed, N., Sep 26 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 39, p. 14489-14494 6 p.

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Estradiol
Brain Injuries
Estrogens
2007
45 Citations (Scopus)

A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat

Iliff, J., Close, L. N., Selden, N. & Alkayed, N., Jul 2007, In : Experimental Physiology. 92, 4, p. 653-658 6 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Epoxide Hydrolases
Eicosanoids
Cytochrome P-450 Enzyme System
Acids
40 Citations (Scopus)

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. & Hurn, P. D., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Dihydrotestosterone
Wounds and Injuries
Middle Cerebral Artery Infarction
Genes
Reperfusion
32 Citations (Scopus)

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. & Hurn, P. D., Sep 7 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 9, p. 1553-1562 10 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Androgens
Wounds and Injuries
Brain Ischemia
Reperfusion
Estradiol
Middle Cerebral Artery Infarction
Brain
Estrogens
Brain Ischemia

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Yang, Z., Wang, L., Hua, Z., Hurn, P. D., Alkayed, N. & Xu, Y., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Estradiol
Estrogens
Stroke
Apoptosis
anti-Fas monoclonal antibody
46 Citations (Scopus)

Mitochondrial mechanism of neuroprotection by CART

Mao, P., Ardeshiri, A., Jacks, R., Yang, S., Hurn, P. D. & Alkayed, N., Aug 2007, In : European Journal of Neuroscience. 26, 3, p. 624-632 9 p.

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Adenosine Triphosphate
Oxygen
Glucose
92 Citations (Scopus)

Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury

Koerner, I., Jacks, R., De Barber, A., Koop, D., Mao, P., Grant, D. F. & Alkayed, N., Apr 25 2007, In : Journal of Neuroscience. 27, 17, p. 4642-4649 8 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Wounds and Injuries
Genes
Cell Death
Enzymes

Role of MAPK in neuroprotection by cart in ischemic stroke

Xu, Y., Jia, J., Hua, Z., Hurn, P. & Alkayed, N., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Stroke
Small Interfering RNA
Middle Cerebral Artery Infarction
95 Citations (Scopus)

Role of P450 aromatase in sex-specific astrocytic cell death

Liu, M., Hurn, P. D., Roselli, C. & Alkayed, N., Jan 5 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 1, p. 135-141 7 p.

Research output: Contribution to journalArticle

Aromatase
Cell Death
Astrocytes
Oxygen
Glucose
79 Citations (Scopus)

Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection

Dziennis, S., Jia, T., Ronnekleiv, O., Hurn, P. D. & Alkayed, N., Jul 4 2007, In : Journal of Neuroscience. 27, 27, p. 7268-7274 7 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Estradiol
Middle Cerebral Artery Infarction
Transcriptional Activation
Microtubule-Associated Proteins

Sex-specific anti-oxidant capacities in astrocytes

Liu, M., Alkayed, N., Oyarzabal, E. & Hurn, P. D., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Oxidants
Astrocytes
Glutathione Peroxidase
Catalase
Superoxide Dismutase
56 Citations (Scopus)

Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2

Yang, S., Bhardwaj, A., Cheng, J., Alkayed, N., Hurn, P. D. & Kirsch, J., May 2007, In : Anesthesia and Analgesia. 104, 5, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

sigma Receptors
Oxygen
Glucose
In Situ Nick-End Labeling
DNA Damage
143 Citations (Scopus)

Soluble epoxide hydrolase: A novel therapeutic target in stroke

Zhang, W., Koerner, I., Noppens, R., Grafe, M., Tsai, H. J., Morisseau, C., Luria, A., Hammock, B. D., Falck, J. R. & Alkayed, N., Dec 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 12, p. 1931-1940 10 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
lauric acid
Stroke
Cerebrovascular Circulation
Esters

Soluble epoxide hydrolase: Sex differences and role in estrogen-mediated neuroprotection

Zhang, W., Iliff, J., Alhadid, Y. K., Ardeshiri, A., Koerner, I., Hurn, P. D. & Alkayed, N., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Epoxide Hydrolases
Sex Characteristics
Estrogens
Reperfusion
Middle Cerebral Artery Infarction
2008
15 Citations (Scopus)

Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats

Dziennis, S., Yang, D., Cheng, J., Anderson, K. A., Alkayed, N., Hurn, P. D. & Lein, P. J., Apr 2008, In : Environmental Health Perspectives. 116, 4, p. 474-480 7 p.

Research output: Contribution to journalArticle

Chlorodiphenyl (54% Chlorine)
Polychlorinated Biphenyls
Rats
PCB
Stroke
7 Citations (Scopus)

In vivo cerebrovascular effects of cocaine- and amphetamine-regulated transcript (CART) peptide

Iliff, J., Alkayed, N., Golshani, K. J., Weinstein, J., Traystman, R. J. & West, G. A., Jul 2008, In : Journal of Cardiovascular Pharmacology. 52, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

Amphetamine
Cocaine
Peptides
Constriction
Arterioles
20 Citations (Scopus)

Lack of sex-linked differences in cerebral edema and aquaporin-4 expression after experimental stroke

Liu, X., Zhang, W., Alkayed, N., Froehner, S. C., Adams, M. E., Amiry-Moghaddam, M., Ottersen, O. P., Hurn, P. D. & Bhardwaj, A., Dec 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 12, p. 1898-1906 9 p.

Research output: Contribution to journalArticle

Aquaporin 4
Brain Edema
Sex Characteristics
Stroke
Cerebrovascular Circulation