• 6066 Citations
  • 43 h-Index
1994 …2020

Research output per year

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Research Output

Article

17β-Estradiol reduces stroke injury in estrogen-deficient female animals

Rusa, R., Alkayed, N. J., Crain, B. J., Traystman, R. J., Kimes, A. S., London, E. D., Klaus, J. A. & Hurn, P. D., Aug 1999, In : Stroke. 30, 8, p. 1665-1670 6 p.

Research output: Contribution to journalArticle

Open Access
266 Scopus citations

18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase

Horti, A. G., Wang, Y., Minn, I., Lan, X., Wang, J., Koehler, R. C., Alkayed, N., Dannals, R. F. & Pomper, M. G., Nov 1 2016, In : Journal of Nuclear Medicine. 57, 11, p. 1817-1822 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma

Johnson, L. A., Zuloaga, K. L., Kugelman, T. L., Mader, K. S., Morré, J. T., Zuloaga, D. G., Weber, S., Marzulla, T., Mulford, A., Button, D., Lindner, J., Alkayed, N., Stevens, J. F. & Raber, J., Jan 1 2016, In : EBioMedicine. 3, p. 26-42 17 p.

Research output: Contribution to journalArticle

25 Scopus citations

Anesthetic choice of halothane versus propofol impact on experimental perioperative stroke

Bhardwaj, A., Castro, A. F., Alkayed, N. J., Hurn, P. D. & Kirsch, J. R., Jan 1 2001, In : Stroke. 32, 8, p. 1920-1925 6 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Mar 2014, In : Metabolic brain disease. 29, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat

Iliff, J. J., Close, L. N., Selden, N. R. & Alkayed, N. J., Jul 2007, In : Experimental physiology. 92, 4, p. 653-658 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response

Johnson, L. A., Torres, E. R., Weber Boutros, S., Patel, E., Akinyeke, T., Alkayed, N. & Raber, J., Jan 1 2017, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

11 Scopus citations

Automated segmentation and enhancement of optical coherence tomography-acquired images of rodent brain

Baran, U., Zhu, W., Choi, W. J., Omori, M., Zhang, W., Alkayed, N. & Wang, R. K., Sep 1 2016, In : Journal of Neuroscience Methods. 270, p. 132-137 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
15 Scopus citations

CaMKKβ-Dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation

Zhou, X., Cao, Y., Ao, G., Hu, L., Liu, H., Wu, J., Wang, X., Jin, M., Zheng, S., Zhen, X., Alkayed, N. J., Jia, J. & Cheng, J., Oct 20 2014, In : Antioxidants and Redox Signaling. 21, 12, p. 1741-1758 18 p.

Research output: Contribution to journalArticle

61 Scopus citations

Characterization of a new double-filament model of focal cerebral ischemia in heme oxygenase-2-deficient mice

Goto, S., Sampei, K., Alkayed, N. J., Doré, S. & Koehler, R. C., Jul 1 2003, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 285, 1 54-1, p. R222-R230

Research output: Contribution to journalArticle

15 Scopus citations

Cocaine- and amphetamine-regulated transcript (CART) peptide: A vasoactive role in the cerebral circulation

Iliff, J. J., Alkayed, N. J., Gloshani, K. J., Traystman, R. J. & West, G. A., Oct 1 2005, In : Journal of Cerebral Blood Flow and Metabolism. 25, 10, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Coronary autoregulation is abnormal in syndrome X: Insights using myocardial contrast echocardiography

Rinkevich, D., Belcik, T., Gupta, N. C., Cannard, E., Alkayed, N. J. & Kaul, S., Mar 1 2013, In : Journal of the American Society of Echocardiography. 26, 3, p. 290-296 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
15 Scopus citations

Cytochrome P450 eicosanoids in cerebrovascular function and disease

Davis, C., Liu, X. & Alkayed, N., 2017, (Accepted/In press) In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

15 Scopus citations

Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

Mao, L., Jia, J., Zhou, X., Xiao, Y., Wang, Y., Mao, X., Zhen, X., Guan, Y., Alkayed, N. J. & Cheng, J., Feb 2 2013, In : Neuroscience. 231, p. 272-281 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. J. & Hurn, P. D., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BO11-06

Research output: Contribution to journalArticle

39 Scopus citations

Deleterious effects of dihydrotestosterone on cerebral ischemic injury

Cheng, J., Alkayed, N. J. & Hurn, P. D., Sep 7 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 9, p. 1553-1562 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Dependency of Cortical Functional Hyperemia to Forepaw Stimulation on Epoxygenase and Nitric Oxide Synthase Activities in Rats

Peng, X., Zhang, C., Alkayed, N. J., Harder, D. R. & Koehler, R. C., May 2004, In : Journal of Cerebral Blood Flow and Metabolism. 24, 5, p. 509-517 9 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations

Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats

Dziennis, S., Yang, D., Cheng, J., Anderson, K. A., Alkayed, N. J., Hurn, P. D. & Lein, P. J., Apr 1 2008, In : Environmental health perspectives. 116, 4, p. 474-480 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress

Jia, J., Xiao, Y., Wang, W., Qing, L., Xu, Y., Song, H., Zhen, X., Ao, G., Alkayed, N. J. & Cheng, J., Jun 1 2013, In : Neurochemistry International. 62, 8, p. 1072-1078 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Different immunological mechanisms govern protection from experimental stroke in young and older mice with recombinant TCR ligand therapy

Dotson, A. L., Zhu, W., Libal, N., Alkayed, N. J. & Offner, H., Jan 1 2014, In : Frontiers in Cellular Neuroscience. 8, SEP, p. 1-13 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Disrupting dimerization translocates soluble epoxide hydrolase to peroxisomes

Nelson, J. W., Das, A. J., Barnes, A. & Alkayed, N., May 1 2016, In : PLoS One. 11, 5, e0152742.

Research output: Contribution to journalArticle

4 Scopus citations

Effect of thermostable mutations on the neurotensin receptor 1 (NTSR1) activation state

Nagarajan, S., Alkayed, N. J., Kaul, S. & Barnes, A. P., Jan 22 2020, In : Journal of Biomolecular Structure and Dynamics. 38, 2, p. 340-353 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
3 Scopus citations

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice

Lee, C. R., Imig, J. D., Edin, M. L., Foley, J., DeGraff, L. M., Bradbury, J. A., Graves, J. P., Lih, F. B., Clark, J., Myers, P., Perrow, A. L., Lepp, A. N., Kannon, M. A., Ronnekleiv, O. K., Alkayed, N. J., Falck, J. R., Tomer, K. B. & Zeldin, D. C., Oct 2010, In : FASEB Journal. 24, 10, p. 3770-3781 12 p.

Research output: Contribution to journalArticle

107 Scopus citations

Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels

Iliff, J. J., Wang, R., Zeldin, D. C. & Alkayed, N. J., May 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 296, 5, p. H1352-H1363

Research output: Contribution to journalArticle

54 Scopus citations
20 Scopus citations

Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures

Abdu, E., Bruun, D. A., Yang, D., Yang, J., Inceoglu, B., Hammock, B. D., Alkayed, N. J. & Lein, P. J., May 1 2011, In : Journal of neurochemistry. 117, 4, p. 632-642 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume

Shim, C. Y., Kim, S., Chadderdon, S., Wu, M., Qi, Y., Xie, A., Alkayed, N. J., Davidson, B. P. & Lindner, J. R., Dec 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 12, p. E1097-E1104

Research output: Contribution to journalArticle

15 Scopus citations

Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA

Joh, H. D., Searles, R. V., Selmanoff, M., Alkayed, N. J., Koehler, R. C., Hurn, P. D. & Murphy, S. J., Apr 1 2006, In : Journal of Cerebral Blood Flow and Metabolism. 26, 4, p. 518-526 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Estradiol is protective against ischemic brain damage through signal trasducer and activator of transcription 3 (STAT3)

Dziennis, S., Jia, T., Ronnekleiv, O. K., Hurn, P. D. & Alkayed, N. J., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BP8-03U

Research output: Contribution to journalArticle

Estrogen and Bcl-2: Gene induction and effect of transgene in experimental stroke

Alkayed, N. J., Goto, S., Sugo, N., Joh, H. D., Klaus, J., Crain, B. J., Bernard, O., Traystman, R. J. & Hurn, P. D., Oct 1 2001, In : Journal of Neuroscience. 21, 19, p. 7543-7550 8 p.

Research output: Contribution to journalArticle

166 Scopus citations

Estrogen-enhanced expression of bcl-2 mRNA in rat brain after experimental stroke

Alkayed, N. J., McCune, S. K., Crain, B. J., Traystman, R. J. & Hurn, P. D., Mar 20 1998, In : FASEB Journal. 12, 5, p. A954

Research output: Contribution to journalArticle

8 Scopus citations

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Yang, Z., Wang, L., Hua, Z., Hurn, P. D., Alkayed, N. J. & Xu, Y., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. BP43-01H

Research output: Contribution to journalArticle

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Guan, D., Zhu, W., Alkayed, N. J., Wang, M. M., Hua, Z. & Xu, Y., Jan 1 2009, In : Experimental Neurology. 215, 1, p. 48-52 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Estrogen-mediated renoprotection following cardiac arrest and cardiopulmonary resuscitation is robust to GPR30 gene deletion

Hutchens, M. P., Kosaka, Y., Zhang, W., Fujiyoshi, T., Murphy, S., Alkayed, N. & Anderson, S., Jun 12 2014, In : PloS one. 9, 6, e99910.

Research output: Contribution to journalArticle

10 Scopus citations

Estrogen receptor antagonist ICI182,780 exacerbates ischemic injury in female mouse

Sawada, M., Alkayed, N. J., Goto, S., Grain, B. J., Traystman, R. J., Shaivitz, A., Nelson, R. J. & Hurn, P. D., Jan 1 2000, In : Journal of Cerebral Blood Flow and Metabolism. 20, 1, p. 112-118 7 p.

Research output: Contribution to journalArticle

Open Access
127 Scopus citations

Experimental stroke in the female diabetic, db/db, mouse

Vannucci, S. J., Willing, L. B., Goto, S., Alkayed, N. J., Brucklacher, R. M., Wood, T. L., Towfighi, J., Hurn, P. D. & Simpson, I. A., Jan 1 2001, In : Journal of Cerebral Blood Flow and Metabolism. 21, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

Open Access
115 Scopus citations

Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid

Liu, X., Qian, Z. Y., Xie, F., Fan, W., Nelson, J. W., Xiao, X., Kaul, S., Barnes, A. & Alkayed, N., Apr 28 2016, (Accepted/In press) In : Prostaglandins and Other Lipid Mediators.

Research output: Contribution to journalArticle

14 Scopus citations

Gender-based differences in Na+-K+ adenosine triphosphatase activity occur in the microcirculation of the diabetic rat brain

Sieber, F. E., Hurn, P., Alkayed, N. J. & Traystman, R. J., Jan 1 2001, In : Anesthesiology. 94, 2, p. 372-375 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Gender-linked brain injury in experimental stroke

Alkayed, N. J., Harukuni, I., Kimes, A. S., London, E. D., Traystman, R. J. & Hurn, P. D., Jan 1998, In : Stroke. 29, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

Open Access
599 Scopus citations

Genetic variation in soluble epoxide hydrolase: Association with outcome after aneurysmal subarachnoid hemorrhage

Martini, R. P., Ward, J., Siler, D. A., Eastman, J. M., Nelson, J. W., Borkar, R. N., Alkayed, N. J., Dogan, A. & Cetas, J. S., Dec 1 2014, In : Journal of neurosurgery. 121, 6, p. 1359-1366 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats

Li, P., Zou, A. P., Aj-Kayed, N. J., Rusch, N. J. & Harder, D. R., Jun 1994, In : Hypertension. 23, 6, p. 912-918 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Heme oxygenase-2 is neuroprotective in cerebral ischemia

Doré, S., Sampei, K., Goto, S., Alkayed, N. J., Guastella, D., Blackshaw, S., Gallagher, M., Traystman, R. J., Hurn, P. D., Koehler, R. C. & Snyder, S. H., Dec 1 1999, In : Molecular Medicine. 5, 10, p. 656-663 8 p.

Research output: Contribution to journalArticle

131 Scopus citations

High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats

Antezana, D. F., Clatterbuck, R. E., Alkayed, N. J., Murphy, S. J., Anderson, L. G., Frazier, J., Hurn, P. D., Traystman, R. J. & Tamargo, R. J., Apr 1 2003, In : Journal of neurosurgery. 98, 4, p. 860-866 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion

Zuloaga, K. L., Johnson, L. A., Roese, N. E., Marzulla, T., Zhang, W., Nie, X., Alkayed, F. N., Hong, C., Grafe, M., Pike, M., Raber, J. & Alkayed, N., Jul 1 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 7, p. 1257-1270 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux

Xie, H., Xu, Q., Jia, J., Ao, G., Sun, Y., Hu, L., Alkayed, N. J., Wang, C. & Cheng, J., Mar 13 2015, In : Biochemical and Biophysical Research Communications. 458, 3, p. 632-638 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia

Wang, Y., Jia, J., Ao, G., Hu, L., Liu, H., Xiao, Y., Du, H., Alkayed, N. J., Liu, C. F. & Cheng, J., Jun 2014, In : Journal of Neurochemistry. 129, 5, p. 827-838 12 p.

Research output: Contribution to journalArticle

68 Scopus citations
6 Scopus citations