• 5799 Citations
  • 42 h-Index
19942019
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Research Output 1994 2019

  • 5799 Citations
  • 42 h-Index
  • 128 Article
  • 1 Chapter
  • 1 Review article
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Article
2019
1 Citation (Scopus)
GTP-Binding Proteins
Neurotensin
Mutation
neurotensin (8-13)
Amino Acid Substitution
Electrosurgery
Patient Positioning
Implantable Defibrillators
Electromagnetic Phenomena
Umbilicus
Myocardium
Endothelial Cells
Nitric Oxide Synthase Type III
Acids
Oxygen
2017
2 Citations (Scopus)

Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response

Johnson, L. A., Torres, E. R., Weber Boutros, S., Patel, E., Akinyeke, T., Alkayed, N. & Raber, J., Jan 1 2017, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Apolipoprotein E4
High Fat Diet
Meals
Insulin Resistance
Protein Isoforms
10 Citations (Scopus)

Cytochrome P450 eicosanoids in cerebrovascular function and disease

Davis, C., Liu, X. & Alkayed, N., 2017, (Accepted/In press) In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Cerebrovascular Disorders
Eicosanoids
Cytochrome P-450 Enzyme System
Wounds and Injuries
Brain Diseases
Eicosanoids
Brain Injuries
Hydroxyeicosatetraenoic Acids
Reactive Oxygen Species
Brain
6 Citations (Scopus)

Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing

Vatankhah, N., Jahangiri, Y., Landry, G., Mclafferty, R., Alkayed, N., Moneta, G. G. & Azarbal, A., Feb 1 2017, In : Journal of Vascular Surgery. 65, 2, p. 478-483 6 p.

Research output: Contribution to journalArticle

Wound Healing
Neutrophils
Amputation
Ulcer
Lymphocytes
2016
6 Citations (Scopus)

18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase

Horti, A. G., Wang, Y., Minn, I., Lan, X., Wang, J., Koehler, R. C., Alkayed, N., Dannals, R. F. & Pomper, M. G., Nov 1 2016, In : Journal of Nuclear Medicine. 57, 11, p. 1817-1822 6 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Papio
Brain
Knockout Mice
Radioactivity
19 Citations (Scopus)

Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma

Johnson, L. A., Zuloaga, K. L., Kugelman, T. L., Mader, K. S., Morré, J. T., Zuloaga, D. G., Weber, S., Marzulla, T., Mulford, A., Button, D., Lindner, J., Alkayed, N., Stevens, J. F. & Raber, J., Jan 1 2016, In : EBioMedicine. 3, p. 26-42 17 p.

Research output: Contribution to journalArticle

Dietary Fats
Nutrition
Plasmas
Data storage equipment
Medical problems
13 Citations (Scopus)

Automated segmentation and enhancement of optical coherence tomography-acquired images of rodent brain

Baran, U., Zhu, W., Choi, W. J., Omori, M., Zhang, W., Alkayed, N. & Wang, R. K., Sep 1 2016, In : Journal of Neuroscience Methods. 270, p. 132-137 6 p.

Research output: Contribution to journalArticle

Optical Coherence Tomography
Rodentia
Brain
Ophthalmology
Neurosciences
4 Citations (Scopus)

Disrupting dimerization translocates soluble epoxide hydrolase to peroxisomes

Nelson, J. W., Das, A. J., Barnes, A. & Alkayed, N., May 1 2016, In : PLoS One. 11, 5, e0152742.

Research output: Contribution to journalArticle

epoxide hydrolase
Epoxide Hydrolases
Peroxisomes
dimerization
Dimerization
9 Citations (Scopus)

Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid

Liu, X., Qian, Z. Y., Xie, F., Fan, W., Nelson, J. W., Xiao, X., Kaul, S., Barnes, A. & Alkayed, N., Apr 28 2016, (Accepted/In press) In : Prostaglandins and Other Lipid Mediators.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Screening
Cardiovascular Physiological Phenomena
Prostaglandin Receptors
Physiology
21 Citations (Scopus)

High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion

Zuloaga, K. L., Johnson, L. A., Roese, N. E., Marzulla, T., Zhang, W., Nie, X., Alkayed, F. N., Hong, C., Grafe, M., Pike, M., Raber, J. & Alkayed, N., Jul 1 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 7, p. 1257-1270 14 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
High Fat Diet
Blood Vessels
Cognition
Fear
5 Citations (Scopus)

Partial MHC class II constructs as novel immunomodulatory therapy for stroke

Benedek, G., Vandenbark, A., Alkayed, N. & Offner, H., Sep 1 2016, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

Immunomodulation
Stroke
Brain Ischemia
Thrombectomy
Experimental Arthritis
5 Citations (Scopus)

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium

Jia, J., Davis, C., Zhang, W., Edin, M. L., Jouihan, S., Jia, T., Bradbury, J. A., Graves, J. P., DeGraff, L. M., Lee, C. R., Ronnekleiv, O., Wang, R., Xu, Y., Zeldin, D. C. & Alkayed, N., May 1 2016, In : Experimental Neurology. 279, p. 75-85 11 p.

Research output: Contribution to journalArticle

Vascular Endothelium
Protein Isoforms
Cytochrome P-450 Enzyme System
Transgenic Mice
Brain Ischemia
8 Citations (Scopus)

Temporal changes in skeletal muscle capillary responses and endothelial-derived vasodilators in obesity-related insulin resistance

Chadderdon, S., Belcik, J. T., Bader, L., Peters, D., Kievit, P., Alkayed, N., Kaul, S., Grove, K. & Lindner, J., Aug 1 2016, In : Diabetes. 65, 8, p. 2249-2257 9 p.

Research output: Contribution to journalArticle

Blood Volume
Vasodilator Agents
Insulin Resistance
Skeletal Muscle
Obesity

Vapor Pressures of Anesthetic Agents at Temperatures Below 0°C and a Novel Anesthetic Delivery Device

Schenning, K. J., Casson, H., Click, S. V., Brambrink, L., Chatkupt, T. T., Alkayed, N. & Hutchens, M., Sep 13 2016, (Accepted/In press) In : Anesthesia and Analgesia.

Research output: Contribution to journalArticle

Vapor Pressure
Anesthetics
Equipment and Supplies
Temperature
Nebulizers and Vaporizers
2015
9 Citations (Scopus)

A novel mouse model of thromboembolic stroke

Chen, Y., Zhu, W., Zhang, W., Libal, N., Murphy, S. J., Offner, H. & Alkayed, N., Dec 30 2015, In : Journal of Neuroscience Methods. 256, p. 203-211 9 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
Stroke
Lasers
Thrombosis
Catheters
49 Citations (Scopus)

Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux

Xie, H., Xu, Q., Jia, J., Ao, G., Sun, Y., Hu, L., Alkayed, N., Wang, C. & Cheng, J., Mar 13 2015, In : Biochemical and Biophysical Research Communications. 458, 3, p. 632-638 7 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Hydrogen Sulfide
AMP-Activated Protein Kinases
Reperfusion Injury
Myocardial Ischemia
5 Citations (Scopus)
Ischemic Preconditioning
Hyperglycemia
Endothelial Cells
Reperfusion Injury
In Vitro Techniques
17 Citations (Scopus)

Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment

Zuloaga, K. L., Zhang, W., Yeiser, L. A., Stewart, B., Kukino, A., Nie, X., Roese, N. E., Grafe, M., Pike, M., Raber, J. & Alkayed, N., Jun 5 2015, In : Translational Stroke Research. 6, 5, p. 390-398 9 p.

Research output: Contribution to journalArticle

Atrophy
Blood Vessels
Common Carotid Artery
Cerebrovascular Circulation
Magnetic Resonance Imaging
6 Citations (Scopus)

Partial MHC Constructs Treat Thromboembolic Ischemic Stroke Characterized by Early Immune Expansion

Dotson, A. L., Chen, Y., Zhu, W., Libal, N., Alkayed, N. & Offner, H., Dec 1 2015, (Accepted/In press) In : Translational Stroke Research. p. 1-9 9 p.

Research output: Contribution to journalArticle

Stroke
Thromboembolism
Neutrophils
Spleen
Inflammation
6 Citations (Scopus)

Peroxisomal biogenesis in ischemic brain

Young, J. M., Nelson, J. W., Cheng, J., Zhang, W., Mader, S., Davis, C., Morrison, R. S. & Alkayed, N., Jan 10 2015, In : Antioxidants and Redox Signaling. 22, 2, p. 109-120 12 p.

Research output: Contribution to journalArticle

Neurons
Peroxisomes
Brain
Oxygen
Glucose
2 Citations (Scopus)

Peroxisomal translocation of soluble epoxide hydrolase protects against ischemic stroke injury

Nelson, J. W., Zhang, W., Alkayed, N. & Koerner, I., Sep 3 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 9, p. 1416-1420 5 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Stroke
Wounds and Injuries
Peroxisomes
Cytoplasm
18 Citations (Scopus)

Protective Role of P450 Epoxyeicosanoids in Subarachnoid Hemorrhage

Siler, D. A., Martini, R. P., Ward, J. P., Nelson, J. W., Borkar, R. N., Zuloaga, K. L., Liu, J. J., Fairbanks, S. L., Raskin, J. S., Anderson, V., Dogan, A., Wang, R. K., Alkayed, N. & Cetas, J., 2015, In : Neurocritical Care. 22, 2, p. 306-319 14 p.

Research output: Contribution to journalArticle

Subarachnoid Hemorrhage
Brain Ischemia
Eicosanoids
Epoxide Hydrolases
Cerebrospinal Fluid
9 Citations (Scopus)

Recombinant T-cell receptor ligand RTL1000 limits inflammation and decreases infarct size after experimental ischemic stroke in middle-aged mice

Zhu, W., Dotson, A. L., Libal, N. L., Lapato, A. S., Bodhankar, S., Offner, H. & Alkayed, N., Mar 2 2015, In : Neuroscience. 288, p. 112-119 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Stroke
Ligands
Inflammation
Middle Cerebral Artery Infarction
12 Citations (Scopus)
Epoxide Hydrolases
Gene Deletion
Brain Ischemia
Middle Cerebral Artery Infarction
Perfusion
17 Citations (Scopus)

Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation after Subarachnoid Hemorrhage

Siler, D. A., Berlow, Y. A., Kukino, A., Davis, C., Nelson, J. W., Grafe, M., Ono, H., Cetas, J., Pike, M. & Alkayed, N., Jul 4 2015, In : Stroke. 46, 7, p. 1916-1922 7 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Brain Edema
Subarachnoid Hemorrhage
Hydrocephalus
Blood Vessels
1 Citation (Scopus)

Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant

Xie, F., Li, B. X., Alkayed, N. & Xiao, X., Jan 2 2015, In : Synthetic Communications. 45, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

Arachidonic Acid
Oxidants
Hydrogen Peroxide
Urea
Lipids
8 Citations (Scopus)
Nitric Oxide Synthase Type III
Endothelial Cells
Stroke
Adenosine
Hydroxyeicosatetraenoic Acids
2014
18 Citations (Scopus)

A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A., Alkayed, N. & Offner, H., 2014, In : Metabolic Brain Disease. 29, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

HLA-DR1 Antigen
Brain
Middle Cerebral Artery Infarction
Stroke
Macrophage Migration-Inhibitory Factors
56 Citations (Scopus)

CaMKKβ-Dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation

Zhou, X., Cao, Y., Ao, G., Hu, L., Liu, H., Wu, J., Wang, X., Jin, M., Zheng, S., Zhen, X., Alkayed, N., Jia, J. & Cheng, J., Oct 20 2014, In : Antioxidants and Redox Signaling. 21, 12, p. 1741-1758 18 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Calcium-Calmodulin-Dependent Protein Kinases
AMP-Activated Protein Kinases
Phosphotransferases
Chemical activation
10 Citations (Scopus)
Stroke
Ligands
Therapeutics
Immunotherapy
Atrophy
11 Citations (Scopus)

Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume

Shim, C. Y., Kim, S., Chadderdon, S., Wu, M., Yue, Q., Xie, A., Alkayed, N., Davidson, B. P. & Lindner, J., Dec 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 12, p. E1097-E1104

Research output: Contribution to journalArticle

8,11,14-Eicosatrienoic Acid
Epoxide Hydrolases
Benzoates
Regional Blood Flow
Hyperinsulinism

Erratum to: A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A., Alkayed, N. & Offner, H., 2014, (Accepted/In press) In : Metabolic Brain Disease. p. 1 1 p.

Research output: Contribution to journalArticle

Brain
8 Citations (Scopus)

Estrogen-mediated renoprotection following cardiac arrest and cardiopulmonary resuscitation is robust to GPR30 gene deletion

Hutchens, M., Kosaka, Y., Zhang, W., Fujiyoshi, T., Murphy, S., Alkayed, N. & Anderson, S., Jun 12 2014, In : PLoS One. 9, 6, e99910.

Research output: Contribution to journalArticle

cardiopulmonary resuscitation
Resuscitation
cardiac arrest
gene deletion
Cardiopulmonary Resuscitation
12 Citations (Scopus)

Genetic variation in soluble epoxide hydrolase: association with outcome after aneurysmal subarachnoid hemorrhage

Martini, R. P., Ward, J., Siler, D. A., Eastman, J. M., Nelson, J. W., Borkar, R. N., Alkayed, N., Dogan, A. & Cetas, J., Dec 1 2014, In : Journal of Neurosurgery. 121, 6, p. 1359-1366 8 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Subarachnoid Hemorrhage
Stroke
Brain Ischemia
Glasgow Outcome Scale
63 Citations (Scopus)

Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia

Wang, Y., Jia, J., Ao, G., Hu, L., Liu, H., Xiao, Y., Du, H., Alkayed, N., Liu, C. F. & Cheng, J., 2014, In : Journal of Neurochemistry. 129, 5, p. 827-838 12 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Middle Cerebral Artery Infarction
Brain Ischemia
Blood-Brain Barrier
Evans Blue
27 Citations (Scopus)
Tissue Plasminogen Activator
Subarachnoid Hemorrhage
Intracranial Pressure
Cerebrospinal Fluid
Perfusion
13 Citations (Scopus)

Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke

Zuloaga, K. L., Krasnow, S., Zhu, X., Zhang, W., Jouihan, S. A., Shangraw, R., Alkayed, N. & Marks, D., May 13 2014, In : PLoS One. 9, 5, e97529.

Research output: Contribution to journalArticle

epoxide hydrolase
Epoxide Hydrolases
stroke
Stroke
mice
17 Citations (Scopus)

Preclinical Evaluation of Recombinant T Cell Receptor Ligand RTL1000 as a Therapeutic Agent in Ischemic Stroke

Zhu, W., Casper, A., Libal, N. L., Murphy, S. J., Bodhankar, S., Offner, H. & Alkayed, N., 2014, In : Translational Stroke Research. 6, 1, p. 60-68 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Stroke
Ligands
Middle Cerebral Artery Infarction
Transgenic Mice
16 Citations (Scopus)

Recombinant T Cell Receptor Ligand Treatment Improves Neurological Outcome in the Presence of Tissue Plasminogen Activator in Experimental Ischemic Stroke

Zhu, W., Libal, N. L., Casper, A., Bodhankar, S., Offner, H. & Alkayed, N., 2014, In : Translational Stroke Research. 5, 5, p. 612-617 6 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
T-Cell Antigen Receptor
Stroke
Ligands
Middle Cerebral Artery Infarction
8 Citations (Scopus)
Aromatase
Fadrozole
Aromatase Inhibitors
Estrogens
Stroke
23 Citations (Scopus)

Role of soluble epoxide hydrolase in age-related vascular cognitive decline

Nelson, J. W., Young, J. M., Borkar, R. N., Woltjer, R. R., Quinn, J., Silbert, L., Grafe, M. & Alkayed, N., Sep 30 2014, In : Prostaglandins and Other Lipid Mediators. 113-115, p. 30-37 8 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Blood Vessels
Eicosanoids
Brain
Tissue
2013
16 Citations (Scopus)

Coronary autoregulation is abnormal in syndrome X: Insights using myocardial contrast echocardiography

Rinkevich, D., Belcik, T., Gupta, N. C., Cannard, E., Alkayed, N. & Kaul, S., Mar 2013, In : Journal of the American Society of Echocardiography. 26, 3, p. 290-296 7 p.

Research output: Contribution to journalArticle

Echocardiography
Homeostasis
Dipyridamole
Eicosanoids
Gonadal Steroid Hormones
41 Citations (Scopus)

Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

Mao, L., Jia, J., Zhou, X., Xiao, Y., Wang, Y., Mao, X., Zhen, X., Guan, Y., Alkayed, N. & Cheng, J., Feb 2 2013, In : Neuroscience. 231, p. 272-281 10 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Stroke
Axons
Brain
Therapeutics
36 Citations (Scopus)

Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress

Jia, J., Xiao, Y., Wang, W., Qing, L., Xu, Y., Song, H., Zhen, X., Ao, G., Alkayed, N. & Cheng, J., Jun 2013, In : Neurochemistry International. 62, 8, p. 1072-1078 7 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Glutamic Acid
Oxidative Stress
AMP-Activated Protein Kinases
Glyburide
20 Citations (Scopus)

Mechanism of the Sex Difference in Endothelial Dysfunction after Stroke

Davis, C., Fairbanks, S. L. & Alkayed, N., Aug 2013, In : Translational Stroke Research. 4, 4, p. 381-389 9 p.

Research output: Contribution to journalArticle

Sex Characteristics
Stroke
Brain Ischemia
Epoxide Hydrolases
Vasodilation
22 Citations (Scopus)

Role of Endothelial Soluble Epoxide Hydrolase in Cerebrovascular Function and Ischemic Injury

Zhang, W., Davis, C., Edin, M. L., Lee, C. R., Zeldin, D. C. & Alkayed, N., Apr 9 2013, In : PLoS One. 8, 4, e61244.

Research output: Contribution to journalArticle

epoxide hydrolase
Epoxide Hydrolases
mice
Wounds and Injuries
infarction
20 Citations (Scopus)

Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus

Jouihan, S. A., Zuloaga, K. L., Zhang, W., Shangraw, R., Krasnow, S., Marks, D. & Alkayed, N., Oct 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 10, p. 1650-1656 7 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Streptozocin
Type 1 Diabetes Mellitus
Stroke
Hyperglycemia