• 6166 Citations
  • 43 h-Index
1994 …2020

Research output per year

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Research Output

2020

Effect of thermostable mutations on the neurotensin receptor 1 (NTSR1) activation state

Nagarajan, S., Alkayed, N. J., Kaul, S. & Barnes, A. P., Jan 22 2020, In : Journal of Biomolecular Structure and Dynamics. 38, 2, p. 340-353 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response

Johnson, L. A., Torres, E. R., Weber Boutros, S., Patel, E., Akinyeke, T., Alkayed, N. J. & Raber, J., May 1 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 5, p. 770-781 12 p.

Research output: Contribution to journalArticle

15 Scopus citations
3 Scopus citations

Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis

Methner, C., Mishra, A., Golgotiu, K., Li, Y., Wei, W., Yanez, N., Zlokovic, B., Wang, R. K., Alkayed, N., Kaul, S. & Iliff, J., Aug 1 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 317, 2, p. H255-H263

Research output: Contribution to journalArticle

1 Scopus citations

Sex differences in the therapeutic effects of anti-PDL2 neutralizing antibody on stroke

Seifert, H. A., Zhu, W., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Dec 1 2019, In : Metabolic brain disease. 34, 6, p. 1705-1712 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

P450 eicosanoids and reactive oxygen species interplay in brain injury and neuroprotection

Liu, X., Davis, C. M. & Alkayed, N. J., Apr 2018, In : Antioxidants and Redox Signaling. 28, 10, p. 987-1007 21 p.

Research output: Contribution to journalReview article

6 Scopus citations
2017

Cytochrome P450 eicosanoids in cerebrovascular function and disease

Davis, C., Liu, X. & Alkayed, N., 2017, (Accepted/In press) In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

17 Scopus citations

Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing

Vatankhah, N., Jahangiri, Y., Landry, G., Mclafferty, R., Alkayed, N., Moneta, G. G. & Azarbal, A., Feb 1 2017, In : Journal of Vascular Surgery. 65, 2, p. 478-483 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase

Horti, A. G., Wang, Y., Minn, I., Lan, X., Wang, J., Koehler, R. C., Alkayed, N. J., Dannals, R. F. & Pomper, M. G., Nov 1 2016, In : Journal of Nuclear Medicine. 57, 11, p. 1817-1822 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma

Johnson, L. A., Zuloaga, K. L., Kugelman, T. L., Mader, K. S., Morré, J. T., Zuloaga, D. G., Weber, S., Marzulla, T., Mulford, A., Button, D., Lindner, J. R., Alkayed, N. J., Stevens, J. F. & Raber, J., Jan 1 2016, In : EBioMedicine. 3, p. 26-42 17 p.

Research output: Contribution to journalArticle

26 Scopus citations

Automated segmentation and enhancement of optical coherence tomography-acquired images of rodent brain

Baran, U., Zhu, W., Choi, W. J., Omori, M., Zhang, W., Alkayed, N. & Wang, R. K., Sep 1 2016, In : Journal of Neuroscience Methods. 270, p. 132-137 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Disrupting dimerization translocates soluble epoxide hydrolase to peroxisomes

Nelson, J. W., Das, A. J., Barnes, A. P. & Alkayed, N. J., May 1 2016, In : PloS one. 11, 5, e0152742.

Research output: Contribution to journalArticle

4 Scopus citations

Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid

Liu, X., Qian, Z. Y., Xie, F., Fan, W., Nelson, J. W., Xiao, X., Kaul, S., Barnes, A. & Alkayed, N., Apr 28 2016, (Accepted/In press) In : Prostaglandins and Other Lipid Mediators.

Research output: Contribution to journalArticle

17 Scopus citations

High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion

Zuloaga, K. L., Johnson, L. A., Roese, N. E., Marzulla, T., Zhang, W., Nie, X., Alkayed, F. N., Hong, C., Grafe, M., Pike, M., Raber, J. & Alkayed, N., Jul 1 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 7, p. 1257-1270 14 p.

Research output: Contribution to journalArticle

32 Scopus citations

Partial MHC class II constructs as novel immunomodulatory therapy for stroke

Benedek, G., Vandenbark, A., Alkayed, N. & Offner, H., Sep 1 2016, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

8 Scopus citations

Partial MHC Constructs Treat Thromboembolic Ischemic Stroke Characterized by Early Immune Expansion

Dotson, A. L., Chen, Y., Zhu, W., Libal, N., Alkayed, N. J. & Offner, H., Feb 1 2016, In : Translational Stroke Research. 7, 1, p. 70-78 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium

Jia, J., Davis, C. M., Zhang, W., Edin, M. L., Jouihan, S., Jia, T., Bradbury, J. A., Graves, J. P., DeGraff, L. M., Lee, C. R., Ronnekleiv, O., Wang, R., Xu, Y., Zeldin, D. C. & Alkayed, N. J., May 1 2016, In : Experimental Neurology. 279, p. 75-85 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Temporal changes in skeletal muscle capillary responses and endothelial-derived vasodilators in obesity-related insulin resistance

Chadderdon, S., Belcik, J. T., Bader, L., Peters, D., Kievit, P., Alkayed, N., Kaul, S., Grove, K. & Lindner, J., Aug 1 2016, In : Diabetes. 65, 8, p. 2249-2257 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Vapor Pressures of Anesthetic Agents at Temperatures Below 0°C and a Novel Anesthetic Delivery Device

Schenning, K. J., Casson, H., Click, S. V., Brambrink, L., Chatkupt, T. T., Alkayed, N. & Hutchens, M., Sep 13 2016, (Accepted/In press) In : Anesthesia and Analgesia.

Research output: Contribution to journalArticle

2015

A novel mouse model of thromboembolic stroke

Chen, Y., Zhu, W., Zhang, W., Libal, N., Murphy, S. J., Offner, H. & Alkayed, N. J., Dec 30 2015, In : Journal of Neuroscience Methods. 256, p. 203-211 9 p.

Research output: Contribution to journalReview article

15 Scopus citations

Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux

Xie, H., Xu, Q., Jia, J., Ao, G., Sun, Y., Hu, L., Alkayed, N. J., Wang, C. & Cheng, J., Mar 13 2015, In : Biochemical and Biophysical Research Communications. 458, 3, p. 632-638 7 p.

Research output: Contribution to journalArticle

57 Scopus citations
6 Scopus citations

Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment

Zuloaga, K. L., Zhang, W., Yeiser, L. A., Stewart, B., Kukino, A., Nie, X., Roese, N. E., Grafe, M. R., Pike, M. M., Raber, J. & Alkayed, N. J., Oct 10 2015, In : Translational Stroke Research. 6, 5, p. 390-398 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Peroxisomal biogenesis in ischemic brain

Young, J. M., Nelson, J. W., Cheng, J., Zhang, W., Mader, S., Davis, C. M., Morrison, R. S. & Alkayed, N. J., Jan 10 2015, In : Antioxidants and Redox Signaling. 22, 2, p. 109-120 12 p.

Research output: Contribution to journalReview article

9 Scopus citations

Peroxisomal translocation of soluble epoxide hydrolase protects against ischemic stroke injury

Nelson, J. W., Zhang, W., Alkayed, N. J. & Koerner, I. P., Sep 3 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 9, p. 1416-1420 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Protective Role of P450 Epoxyeicosanoids in Subarachnoid Hemorrhage

Siler, D. A., Martini, R. P., Ward, J. P., Nelson, J. W., Borkar, R. N., Zuloaga, K. L., Liu, J. J., Fairbanks, S. L., Raskin, J. S., Anderson, V. C., Dogan, A., Wang, R. K., Alkayed, N. J. & Cetas, J. S., 2015, In : Neurocritical Care. 22, 2, p. 306-319 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Recombinant T-cell receptor ligand RTL1000 limits inflammation and decreases infarct size after experimental ischemic stroke in middle-aged mice

Zhu, W., Dotson, A. L., Libal, N. L., Lapato, A. S., Bodhankar, S., Offner, H. & Alkayed, N. J., Mar 2 2015, In : Neuroscience. 288, p. 112-119 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
16 Scopus citations

Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation after Subarachnoid Hemorrhage

Siler, D. A., Berlow, Y. A., Kukino, A., Davis, C. M., Nelson, J. W., Grafe, M. R., Ono, H., Cetas, J. S., Pike, M. & Alkayed, N. J., Jul 4 2015, In : Stroke. 46, 7, p. 1916-1922 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant

Xie, F., Li, B. X., Alkayed, N. J. & Xiao, X., Jan 2 2015, In : Synthetic Communications. 45, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
8 Scopus citations
2014

A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Mar 2014, In : Metabolic brain disease. 29, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

CaMKKβ-Dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation

Zhou, X., Cao, Y., Ao, G., Hu, L., Liu, H., Wu, J., Wang, X., Jin, M., Zheng, S., Zhen, X., Alkayed, N. J., Jia, J. & Cheng, J., Oct 20 2014, In : Antioxidants and Redox Signaling. 21, 12, p. 1741-1758 18 p.

Research output: Contribution to journalArticle

65 Scopus citations
11 Scopus citations

Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume

Shim, C. Y., Kim, S., Chadderdon, S., Wu, M., Qi, Y., Xie, A., Alkayed, N. J., Davidson, B. P. & Lindner, J. R., Dec 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 12, p. E1097-E1104

Research output: Contribution to journalArticle

15 Scopus citations

Erratum to: A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke (Metabolic Brain Disease (2014) 29, (37-45) DOI: 10.1007/s11011-013-9440- 0)

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Jan 1 2014, In : Metabolic brain disease. 29, 3, 1 p.

Research output: Contribution to journalComment/debate

Estrogen-mediated renoprotection following cardiac arrest and cardiopulmonary resuscitation is robust to GPR30 gene deletion

Hutchens, M. P., Kosaka, Y., Zhang, W., Fujiyoshi, T., Murphy, S., Alkayed, N. & Anderson, S., Jun 12 2014, In : PloS one. 9, 6, e99910.

Research output: Contribution to journalArticle

10 Scopus citations

Genetic variation in soluble epoxide hydrolase: Association with outcome after aneurysmal subarachnoid hemorrhage

Martini, R. P., Ward, J., Siler, D. A., Eastman, J. M., Nelson, J. W., Borkar, R. N., Alkayed, N. J., Dogan, A. & Cetas, J. S., Dec 1 2014, In : Journal of neurosurgery. 121, 6, p. 1359-1366 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia

Wang, Y., Jia, J., Ao, G., Hu, L., Liu, H., Xiao, Y., Du, H., Alkayed, N. J., Liu, C. F. & Cheng, J., Jun 2014, In : Journal of Neurochemistry. 129, 5, p. 827-838 12 p.

Research output: Contribution to journalArticle

69 Scopus citations
30 Scopus citations

Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke

Zuloaga, K. L., Krasnow, S. M., Zhu, X., Zhang, W., Jouihan, S. A., Shangraw, R. E., Alkayed, N. J. & Marks, D. L., May 13 2014, In : PloS one. 9, 5, e97529.

Research output: Contribution to journalArticle

14 Scopus citations

Preclinical Evaluation of Recombinant T Cell Receptor Ligand RTL1000 as a Therapeutic Agent in Ischemic Stroke

Zhu, W., Casper, A., Libal, N. L., Murphy, S. J., Bodhankar, S., Offner, H. & Alkayed, N. J., Jan 1 2014, In : Translational Stroke Research. 6, 1, p. 60-68 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Recombinant T Cell Receptor Ligand Treatment Improves Neurological Outcome in the Presence of Tissue Plasminogen Activator in Experimental Ischemic Stroke

Zhu, W., Libal, N. L., Casper, A., Bodhankar, S., Offner, H. & Alkayed, N. J., Oct 2014, In : Translational Stroke Research. 5, 5, p. 612-617 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Role of aromatase in sex-specific cerebrovascular endothelial function in mice

Zuloaga, K. L., Davis, C. M., Zhang, W. & Alkayed, N. J., Apr 1 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 7, p. H929-H937

Research output: Contribution to journalArticle

11 Scopus citations

Role of soluble epoxide hydrolase in age-related vascular cognitive decline

Nelson, J. W., Young, J. M., Borkar, R. N., Woltjer, R. L., Quinn, J. F., Silbert, L. C., Grafe, M. R. & Alkayed, N. J., Sep 30 2014, In : Prostaglandins and Other Lipid Mediators. 113-115, p. 30-37 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

Coronary autoregulation is abnormal in syndrome X: Insights using myocardial contrast echocardiography

Rinkevich, D., Belcik, T., Gupta, N. C., Cannard, E., Alkayed, N. J. & Kaul, S., Mar 1 2013, In : Journal of the American Society of Echocardiography. 26, 3, p. 290-296 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

Mao, L., Jia, J., Zhou, X., Xiao, Y., Wang, Y., Mao, X., Zhen, X., Guan, Y., Alkayed, N. J. & Cheng, J., Feb 2 2013, In : Neuroscience. 231, p. 272-281 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress

Jia, J., Xiao, Y., Wang, W., Qing, L., Xu, Y., Song, H., Zhen, X., Ao, G., Alkayed, N. J. & Cheng, J., Jun 1 2013, In : Neurochemistry International. 62, 8, p. 1072-1078 7 p.

Research output: Contribution to journalArticle

39 Scopus citations