Marc Loriaux

Associate Professor

  • 5378 Citations
  • 33 h-Index
1991 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 5378 Citations
  • 33 h-Index
  • 67 Article
  • 7 Letter
  • 1 Comment/debate
  • 1 Review article
1991

The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A

Rehfuss, R. P., Walton, K. M., Loriaux, M. M. & Goodman, R. H., Nov 22 1991, In : Journal of Biological Chemistry. 266, 28, p. 18431-18434 4 p.

Research output: Contribution to journalArticle

172 Scopus citations
1993
Open Access
48 Scopus citations
1994

Modulatory function of CREB·CREMα heterodimers depends upon CREMα phosphorylation

Loriaux, M. M., Brennan, R. G. & Goodman, R. H., Nov 18 1994, In : Journal of Biological Chemistry. 269, 46, p. 28839-28843 5 p.

Research output: Contribution to journalArticle

32 Scopus citations
1998

Polyurethane-coated Dacron-covered stentgrafts for tips: Results in swine

Bloch, R., Pavcnik, D., Uchida, B. T., Krajina, A., Kamino, T., Timmermans, H., Loriaux, M. & Hulek, P., Nov 1 1998, In : Cardiovascular and interventional radiology. 21, 6, p. 497-500 4 p.

Research output: Contribution to journalArticle

25 Scopus citations
1999

Stent-grafts for de novo TIPS: Technique and early results

Andrews, R. T., Saxon, R. R., Bloch, R. D., Petersen, B. D., Uchida, B. T., Rabkin, J. M., Loriaux, M. M., Keller, F. S. & Rösch, J., Jan 1 1999, In : Journal of Vascular and Interventional Radiology. 10, 10, p. 1371-1378 8 p.

Research output: Contribution to journalArticle

52 Scopus citations
2000

The square stent-based large vessel occluder: An experimental pilot study

Pavcnik, D., Uchida, B. T., Timmermans, H., Corless, C. L., Loriaux, M., Keller, F. S. & Rosch, J., Jan 1 2000, In : Journal of Vascular and Interventional Radiology. 11, 9, p. 1227-1234 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2001

Bifurcated drum occluder endograft for treatment of abdominal aortic aneurysm: An experimental study in dogs

Pavcnik, D., Uchida, B. T., Timmermans, H., Petersen, B., Loriaux, M., Yamakado, K., Voda, J., Yin, Q., Keller, F. S. & Rösch, J., Jan 1 2001, In : Journal of Vascular and Interventional Radiology. 12, 3, p. 359-364 6 p., 61917.

Research output: Contribution to journalArticle

7 Scopus citations
2002

Lack of suitability of the rabbit model for particulate uterine artery embolization

Binkert, C. A., Andrews, R. T., Pavcnik, D., Uchida, B., Loriaux, M. M., Toyota, N. & Rösch, J., Jan 1 2002, In : Journal of Vascular and Interventional Radiology. 13, 6, p. 609-612 4 p., 61655.

Research output: Contribution to journalArticle

4 Scopus citations
2003

c-CBL is not required for leukemia induction by Bcr-Abl in mice

Dinulescu, D. M., Wood, L. J., Shen, L., Loriaux, M., Corless, C. L., Gross, A. W., Ren, R., Deininger, M. W. N. & Druker, B. J., Dec 4 2003, In : Oncogene. 22, 55, p. 8852-8860 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
100 Scopus citations
2004

Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib

Loriaux, M. & Deininger, M., Nov 1 2004, In : Leukemia and Lymphoma. 45, 11, p. 2197-2203 7 p.

Research output: Contribution to journalReview article

62 Scopus citations

Fallopian tube occlusion with use of a small intestine submucosa device: Evaluation in a rabbit model

Binkert, C. A., Pavcnik, D., Andrews, R. T., Loriaux, M. M., Uchida, B., Brountzos, E. N. & Rösch, J., Jun 2004, In : Journal of Vascular and Interventional Radiology. 15, 6, p. 609-613 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ph-positive and -negative myeloproliferative syndromes may co-exist [1]

Mauro, M. J., Loriaux, M. & Deininger, M. W., Jul 2004, In : Leukemia. 18, 7, p. 1305-1307 3 p.

Research output: Contribution to journalLetter

7 Scopus citations
2005

The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

Levine, R. L., Loriaux, M., Huntly, B. J. P., Loh, M. L., Beran, M., Stoffregen, E., Berger, R., Clark, J. J., Willis, S. G., Nguyen, K. T., Flores, N. J., Estey, E., Gattermann, N., Armstrong, S., Look, A. T., Griffin, J. D., Bernard, O. A., Heinrich, M. C., Gilliland, D. G., Druker, B. & 1 others, Deininger, M. W. N., Nov 15 2005, In : Blood. 106, 10, p. 3377-3379 3 p.

Research output: Contribution to journalArticle

297 Scopus citations
2006

Activating alleles of JAK3 in acute megakaryoblastic leukemia

Walters, D. K., Mercher, T., Gu, T. L., O'Hare, T., Tyner, J. W., Loriaux, M., Goss, V. L., Lee, K. A., Eide, C. A., Wong, M. J., Stoffregen, E. P., McGreevey, L., Nardone, J., Moore, S. A., Crispino, J., Boggon, T. J., Heinrich, M. C., Deininger, M. W., Polakiewicz, R. D., Gilliland, D. G. & 1 others, Druker, B. J., Jul 1 2006, In : Cancer Cell. 10, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

245 Scopus citations

Acute graft-versus-host disease of the heart

Roberts, S. S., Leeborg, N., Loriaux, M., Johnson, F. L., Huang, M. L., Stenzel, P., Thiede, C. & Godder, K. T., Oct 15 2006, In : Pediatric Blood and Cancer. 47, 5, p. 624-628 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Characterization of murine JAK2V617F-positive myeloproliferative disease

Bumm, T. G. P., Elsea, C., Corbin, A. S., Loriaux, M., Sherbenou, D., Wood, L., Deininger, J., Silver, R. T., Druker, B. J. & Deininger, M. W. N., Dec 1 2006, In : Cancer Research. 66, 23, p. 11156-11165 10 p.

Research output: Contribution to journalArticle

154 Scopus citations

Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia

Demehri, S., Corbin, A., Loriaux, M., Druker, B. J. & Deininger, M. W., Mar 1 2006, In : Experimental hematology. 34, 3, p. 284-288 5 p.

Research output: Contribution to journalArticle

15 Scopus citations
2007

Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles

Fröhling, S., Scholl, C., Levine, R. L., Loriaux, M., Boggon, T. J., Bernard, O. A., Berger, R., Döhner, H., Döhner, K., Ebert, B. L., Teckie, S., Golub, T. R., Jiang, J., Schittenhelm, M. M., Lee, B. H., Griffin, J. D., Stone, R. M., Heinrich, M. C., Deininger, M. W., Druker, B. J. & 1 others, Gilliland, D. G., Dec 6 2007, In : Cancer Cell. 12, 6, p. 501-513 13 p.

Research output: Contribution to journalArticle

133 Scopus citations
2008

Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

Agarwal, A., Bumm, T. G. P., Corbin, A. S., O'Hare, T., Loriaux, M., Van Dyke, J., Willis, S. G., Deininger, J., Nakayama, K. I., Druker, B. J. & Deininger, M. W., Sep 1 2008, In : Blood. 112, 5, p. 1960-1970 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

Loriaux, M. M., Levine, R. L., Tyner, J. W., Fröhling, S., Scholl, C., Stoffregen, E. P., Wernig, G., Erickson, H., Eide, C. A., Berger, R., Bernard, O. A., Griffin, J. D., Stone, R. M., Lee, B., Meyerson, M., Heinrich, M. C., Deininger, M. W., Gilliland, D. G. & Druker, B. J., May 1 2008, In : Blood. 111, 9, p. 4788-4796 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia

Tyner, J. W., Walters, D. K., Willis, S. G., Luttropp, M., Oost, J., Loriaux, M., Erickson, H., Corbin, A. S., O'Hare, T., Heinrich, M. C., Deininger, M. W. & Druker, B. J., Feb 15 2008, In : Blood. 111, 4, p. 2238-2245 8 p.

Research output: Contribution to journalArticle

57 Scopus citations
2009

A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

Johnson, K. J., Griswold, I. J., O'Hare, T., Corbin, A. S., Loriaux, M., Deininger, M. W. & Druker, B. J., 2009, In : PloS one. 4, 10, e0007439.

Research output: Contribution to journalArticle

21 Scopus citations

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

O'Hare, T., Shakespeare, W. C., Zhu, X., Eide, C. A., Rivera, V. M., Wang, F., Adrian, L. T., Zhou, T., Huang, W. S., Xu, Q., Metcalf, C. A., Tyner, J. W., Loriaux, M. M., Corbin, A. S., Wardwell, S., Ning, Y., Keats, J. A., Wang, Y., Sundaramoorthi, R., Thomas, M. & 8 others, Zhou, D., Snodgrass, J., Commodore, L., Sawyer, T. K., Dalgarno, D. C., Deininger, M. W. N., Druker, B. J. & Clackson, T., Nov 6 2009, In : Cancer Cell. 16, 5, p. 401-412 12 p.

Research output: Contribution to journalArticle

727 Scopus citations

Functional characterization of an activating TEK mutation in acute myeloid leukemia: A cellular context-dependent activating mutation

Tyner, J. W., Rutenberg-Schoenberg, M. L., Erickson, H., Willis, S. G., O'Hare, T., Deininger, M. W., Druker, B. J. & Loriaux, M. M., Jan 1 2009, In : Leukemia. 23, 7, p. 1345-1348 4 p.

Research output: Contribution to journalLetter

4 Scopus citations

High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia

Tyner, J. W., Loriaux, M. M., Erickson, H., Eide, C. A., Deininger, J., MacPartlin, M., Willis, S. G., Lange, T., Druker, B. J., Kovacsovics, T., Maziarz, R., Gattermann, N. & Deininger, M. W., Jan 1 2009, In : Leukemia. 23, 2, p. 406-409 4 p.

Research output: Contribution to journalLetter

9 Scopus citations

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

Tyner, J. W., Erickson, H., Deininger, M. W. N., Willis, S. G., Eide, C. A., Levine, R. L., Heinrich, M. C., Gattermann, N., Gilliland, D. G., Druker, B. J. & Loriaux, M. M., Feb 19 2009, In : Blood. 113, 8, p. 1749-1755 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

RNAi screen for rapid therapeutic target identification in leukemia patients

Tyner, J. W., Deininger, M. W., Loriaux, M. M., Chang, B. H., Gotli, J. R., Willis, S. G., Erickson, H., Kovacsovics, T., O'Hare, T., Heinrich, M. C. & Druker, B. J., May 26 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 21, p. 8695-8700 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
2010

A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib

McWeeney, S. K., Pemberton, L. C., Loriaux, M. M., Vartanian, K., Willis, S. G., Yochum, G., Wilmot, B., Turpaz, Y., Pillai, R., Druker, B. J., Snead, J. L., MacPartlin, M., O'Brien, S. G., Melo, J. V., Lange, T., Harrington, C. A. & Deininger, M. W. N., Jan 14 2010, In : Blood. 115, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

85 Scopus citations

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

Tyner, J. W., Bumm, T. G., Deininger, J., Wood, L., Aichberger, K. J., Loriaux, M. M., Druker, B. J., Burns, C. J., Fantino, E. & Deininger, M. W., Jun 24 2010, In : Blood. 115, 25, p. 5232-5240 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

MET receptor sequence variants R970C and T992I lack transforming capacity

Tyner, J. W., Fletcher, L. B., Wang, E. Q., Yang, W. F., Rutenberg-Schoenberg, M. L., Beadling, C., Mori, M., Heinrich, M. C., Deininger, M. W., Druker, B. J. & Loriaux, M. M., Aug 1 2010, In : Cancer Research. 70, 15, p. 6233-6237 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Small intestinal submucosa plug for closure of dilated nephrostomy tracts: A pilot study in swine

Kakizawa, H., Conlin, M. J., Pavcnik, D., Uchida, B. T., Loriaux, M., Kim, Y. H., Keller, F. S. & Rösch, J., Jun 1 2010, In : Cardiovascular and interventional radiology. 33, 3, p. 596-600 5 p.

Research output: Contribution to journalArticle

Thrombus formation after percutaneous catheterization and manual compression of the femoral artery in heparinized sheep

Kim, Y. H., Pavcnik, D., Kakizawa, H., Uchida, B. T., Burke, A., Loriaux, M., Keller, F. S. & Rosch, J., Apr 1 2010, In : Cardiovascular and interventional radiology. 33, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2011
8 Scopus citations

CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Lannutti, B. J., Meadows, S. A., Herman, S. E. M., Kashishian, A., Steiner, B., Johnson, A. J., Byrd, J. C., Tyner, J. W., Loriaux, M. M., Deininger, M., Druker, B. J., Puri, K. D., Ulrich, R. G. & Giese, N. A., Jan 13 2011, In : Blood. 117, 2, p. 591-594 4 p.

Research output: Contribution to journalArticle

526 Scopus citations

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Corbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W. & Druker, B. J., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 396-409 14 p.

Research output: Contribution to journalArticle

505 Scopus citations

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies

Gozgit, J. M., Wong, M. J., Wardwell, S., Tyner, J. W., Loriaux, M. M., Mohemmad, Q. K., Narasimhan, N. I., Shakespeare, W. C., Wang, F., Druker, B. J., Clackson, T. & Rivera, V. M., Jun 2011, In : Molecular cancer therapeutics. 10, 6, p. 1028-1035 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Survey of activated FLT3 signaling in leukemia

Gu, T. L., Nardone, J., Wang, Y., Loriaux, M., Villén, J., Beausoleil, S., Tucker, M., Kornhauser, J., Ren, J., MacNeill, J., Gygi, S. P., Druker, B. J., Heinrich, M. C., Rush, J. & Polakiewicz, R. D., 2011, In : PloS one. 6, 4, e19169.

Research output: Contribution to journalArticle

41 Scopus citations

TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

Fleischman, A. G., Aichberger, K. J., Luty, S. B., Bumm, T. G., Petersen, C. L., Doratotaj, S., Vasudevan, K. B., LaTocha, D. H., Yang, F., Press, R. D., Loriaux, M. M., Pahl, H. L., Silver, R. T., Agarwal, A., O'Hare, T., Druker, B. J., Bagby, G. C. & Deininger, M. W., Dec 8 2011, In : Blood. 118, 24, p. 6392-6398 7 p.

Research output: Contribution to journalArticle

130 Scopus citations
2012

An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma

Abraham, J., Chua, Y. X., Glover, J. M., Tyner, J. W., Loriaux, M. M., Kilcoyne, A., Giles, F. J., Nelon, L. D., Carew, J. S., Ouyang, Y., Michalek, J. E., Pal, R., Druker, B. J., Rubin, B. P. & Keller, C., Sep 28 2012, In : Biochemical and Biophysical Research Communications. 426, 3, p. 363-368 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Creation of fibrinogen-enhanced experimental blood clots to evaluate mechanical thrombectomy devices for treatment of acute stroke: An in vitro study

Luo, Z. H., Chung, A., Choi, G., Lin, Y. H., Uchida, B. T., Pavcnik, D., Loriaux, M. M., Nesbit, G. M., Keller, F. S. & Rösch, J., Aug 1 2012, In : Journal of Vascular and Interventional Radiology. 23, 8, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Bicocca, V. T., Chang, B. H., Masouleh, B. K., Muschen, M., Loriaux, M. M., Druker, B. J. & Tyner, J. W., Nov 13 2012, In : Cancer Cell. 22, 5, p. 656-667 12 p.

Research output: Contribution to journalArticle

100 Scopus citations

Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

Agarwal, A., Fleischman, A. G., Petersen, C. L., MacKenzie, R., Luty, S., Loriaux, M., Druker, B. J., Woltjer, R. L. & Deininger, M. W., Sep 27 2012, In : Blood. 120, 13, p. 2658-2668 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
15 Scopus citations

Multiplex high-throughput gene mutation analysis in acute myeloid leukemia

Dunlap, J., Beadling, C., Warrick, A., Neff, T., Fleming, W. H., Loriaux, M., Heinrich, M. C., Kovacsovics, T., Kelemen, K., Leeborg, N., Gatter, K., Braziel, R. M., Press, R., Corless, C. L. & Fan, G., Dec 1 2012, In : Human Pathology. 43, 12, p. 2167-2176 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia

Bains, T., Heinrich, M. C., Loriaux, M. M., Beadling, C., Nelson, D., Warrick, A., Neff, T. L., Tyner, J. W., Dunlap, J., Corless, C. L. & Fan, G., Sep 1 2012, In : Leukemia. 26, 9, p. 2144-2146 3 p.

Research output: Contribution to journalLetter

44 Scopus citations

TSLP signaling network revealed by SILAC-based phosphoproteomics

Zhong, J., Kim, M. S., Chaerkady, R., Wu, X., Huang, T. C., Getnet, D., Mitchell, C. J., Palapetta, S. M., Sharma, J., O'Meally, R. N., Cole, R. N., Yoda, A., Moritz, A., Loriaux, M. M., Rush, J., Weinstock, D. M., Tyner, J. W. & Pandey, A., Jun 1 2012, In : Molecular and Cellular Proteomics. 11, 6

Research output: Contribution to journalArticle

40 Scopus citations
2013

A case study of personalized therapy for osteosarcoma

Davis, L. E., Hofmann, N. E., Li, G., Huang, E. T., Loriaux, M. M., Bracha, S., Helfand, S. C., Mata, J. E., Marley, K., Mansoor, A., Tyner, J. W., Abraham, J., Séguin, B. & Keller, C., Aug 1 2013, In : Pediatric Blood and Cancer. 60, 8, p. 1313-1319 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
4 Scopus citations