Marc Loriaux

Associate Professor

  • 4949 Citations
  • 32 h-Index
1991 …2019
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Research Output 1991 2019

  • 4949 Citations
  • 32 h-Index
  • 73 Article
  • 1 Letter
20 Citations (Scopus)

A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

Johnson, K. J., Griswold, I. J., O'Hare, T., Corbin, A. S., Loriaux, M., Deininger, M. W. & Druker, B., 2009, In : PLoS One. 4, 10, e0007439.

Research output: Contribution to journalArticle

leukemia
binding sites
Leukemia
Binding Sites
myeloid leukemia
45 Citations (Scopus)

Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

Agarwal, A., Bumm, T. G. P., Corbin, A. S., O'Hare, T., Loriaux, M., Van Dyke, J., Willis, S. G., Deininger, J., Nakayama, K. I., Druker, B. & Deininger, M. W., Sep 1 2008, In : Blood. 112, 5, p. 1960-1970 11 p.

Research output: Contribution to journalArticle

S-Phase Kinase-Associated Proteins
Bone Marrow
Cells
F-Box Proteins
Transformed Cell Line
14 Citations (Scopus)

A case study of personalized therapy for osteosarcoma

Davis, L., Hofmann, N. E., Li, G., Huang, E. T., Loriaux, M., Bracha, S., Helfand, S. C., Mata, J. E., Marley, K., Mansoor, A., Tyner, J., Abraham, J., Séguin, B. & Keller, C., Aug 2013, In : Pediatric Blood and Cancer. 60, 8, p. 1313-1319 7 p.

Research output: Contribution to journalArticle

Osteosarcoma
Sarcoma
Canidae
Neoplasms
Therapeutics
240 Citations (Scopus)

Activating alleles of JAK3 in acute megakaryoblastic leukemia

Walters, D. K., Mercher, T., Gu, T. L., O'Hare, T., Tyner, J., Loriaux, M., Goss, V. L., Lee, K. A., Eide, C. A., Wong, M. J., Stoffregen, E. P., McGreevey, L., Nardone, J., Moore, S. A., Crispino, J., Boggon, T. J., Heinrich, M., Deininger, M. W., Polakiewicz, R. D., Gilliland, D. G. & 1 others, Druker, B., Jul 2006, In : Cancer Cell. 10, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

Leukemia, Megakaryoblastic, Acute
Alleles
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Mutation
9 Citations (Scopus)

Acute graft-versus-host disease of the heart

Roberts, S. S., Leeborg, N., Loriaux, M., Johnson, F. L., Huang, M. L., Stenzel, P., Thiede, C. & Godder, K. T., Oct 15 2006, In : Pediatric Blood and Cancer. 47, 5, p. 624-628 5 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Bone Marrow Transplantation
Pediatrics
Chimerism
Gastrointestinal Tract
79 Citations (Scopus)

A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib

McWeeney, S., Pemberton, L. C., Loriaux, M., Vartanian, K., Willis, S. G., Yochum, G., Wilmot, B., Turpaz, Y., Pillai, R., Druker, B., Snead, J. L., MacPartlin, M., O'Brien, S. G., Melo, J. V., Lange, T., Harrington, C. C. & Deininger, M. W. N., Jan 14 2010, In : Blood. 115, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic Phase
Transcriptome
Gene expression
Cytogenetics
Classifiers
22 Citations (Scopus)
Neoplasm Drug Resistance
Exosomes
Protein Kinase Inhibitors
MicroRNAs
Mesenchymal Stromal Cells
9 Citations (Scopus)

An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma

Abraham, J., Chua, Y. X., Glover, J. M., Tyner, J., Loriaux, M., Kilcoyne, A., Giles, F. J., Nelon, L. D., Carew, J. S., Ouyang, Y., Michalek, J. E., Pal, R., Druker, B., Rubin, B. P. & Keller, C., Sep 28 2012, In : Biochemical and Biophysical Research Communications. 426, 3, p. 363-368 6 p.

Research output: Contribution to journalArticle

Alveolar Rhabdomyosarcoma
Rhabdomyosarcoma
Tumors
Cell culture
Primary Cell Culture
686 Citations (Scopus)

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

O'Hare, T., Shakespeare, W. C., Zhu, X., Eide, C. A., Rivera, V. M., Wang, F., Adrian, L. T., Zhou, T., Huang, W. S., Xu, Q., Metcalf, C. A., Tyner, J., Loriaux, M., Corbin, A. S., Wardwell, S., Ning, Y., Keats, J. A., Wang, Y., Sundaramoorthi, R., Thomas, M. & 8 others, Zhou, D., Snodgrass, J., Commodore, L., Sawyer, T. K., Dalgarno, D. C., Deininger, M. W. N., Druker, B. & Clackson, T., Nov 6 2009, In : Cancer Cell. 16, 5, p. 401-412 12 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mutation
Phosphotransferases
Therapeutics
Mutagenesis
39 Citations (Scopus)

A potential therapeutic strategy for chronic lymphocytic leukemia by combining idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor

Burke, R. T., Meadows, S., Loriaux, M., Currie, K. S., Mitchell, S. A., Maciejewski, P., Clarke, A. S., Dipaolo, J. A., Druker, B., Lannutti, B. J. & Spurgeon, S., 2014, In : Oncotarget. 5, 4, p. 908-915 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Bone Marrow
Disease Eradication
Therapeutics
7 Citations (Scopus)
Chromosome Aberrations
Chromosomes, Human, Pair 7
Cytogenetics
Mutation
Philadelphia Chromosome
15 Citations (Scopus)

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

Agarwal, A., Mackenzie, R. J., Besson, A., Jeng, S., Carey, A., LaTocha, D. H., Fleischman, A. G., Duquesnes, N., Eide, C. A., Vasudevan, K. B., Loriaux, M., Firpo, E., Cortes, J. E., McWeeney, S., O'Hare, T., Roberts, J. M., Druker, B. & Deininger, M. W., Nov 20 2014, In : Blood. 124, 22, p. 3260-3273 14 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tumors
Leukemia
Cyclin-Dependent Kinases
7 Citations (Scopus)

Bifurcated drum occluder endograft for treatment of abdominal aortic aneurysm: An experimental study in dogs

Pavcnik, D., Uchida, B., Timmermans, H., Petersen, B., Loriaux, M., Yamakado, K., Voda, J., Yin, Q. M., Keller, F. & Rosch, J., 2001, In : Journal of Vascular and Interventional Radiology. 12, 3, p. 359-364 6 p.

Research output: Contribution to journalArticle

Abdominal Aortic Aneurysm
Dogs
Stents
Iliac Artery
Polytetrafluoroethylene
501 Citations (Scopus)

CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Lannutti, B. J., Meadows, S. A., Herman, S. E. M., Kashishian, A., Steiner, B., Johnson, A. J., Byrd, J. C., Tyner, J., Loriaux, M., Deininger, M., Druker, B., Puri, K. D., Ulrich, R. G. & Giese, N. A., Jan 13 2011, In : Blood. 117, 2, p. 591-594 4 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Phosphatidylinositol 3-Kinases
B-Lymphocytes
Cells
Neoplasms
13 Citations (Scopus)

c-CBL is not required for leukemia induction by Bcr-Abl in mice

Dinulescu, D. M., Wood, L., Shen, L., Loriaux, M., Corless, C., Gross, A. W., Ren, R., Deininger, M. W. N. & Druker, B., Dec 4 2003, In : Oncogene. 22, 55, p. 8852-8860 9 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-cbl
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
bcr-abl Fusion Proteins
Cell Line
151 Citations (Scopus)

Characterization of murine JAK2V617F-positive myeloproliferative disease

Bumm, T. G. P., Elsea, C., Corbin, A. S., Loriaux, M., Sherbenou, D., Wood, L., Deininger, J., Silver, R. T., Druker, B. & Deininger, M. W. N., Dec 1 2006, In : Cancer Research. 66, 23, p. 11156-11165 10 p.

Research output: Contribution to journalArticle

Megakaryocyte-Erythroid Progenitor Cells
Myeloproliferative Disorders
Polycythemia Vera
Polycythemia
Primary Myelofibrosis
61 Citations (Scopus)

Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib

Loriaux, M. & Deininger, M., Nov 2004, In : Leukemia and Lymphoma. 45, 11, p. 2197-2203 7 p.

Research output: Contribution to journalArticle

Philadelphia Chromosome
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Chromosome Aberrations
Clonal Evolution
Cytogenetics
4 Citations (Scopus)
Precision Medicine
Genes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Small Interfering RNA
Genome
37 Citations (Scopus)

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Huan, J., Hornick, N. I., Goloviznina, N. A., Kamimae-Lanning, A. N., David, L., Wilmarth, P., Mori, M. T., Chevillet, J. R., Narla, A., Roberts, C., Loriaux, M., Chang, B. & Kurre, P., Jun 25 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Exosomes
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Bone Marrow
Exosome Multienzyme Ribonuclease Complex
13 Citations (Scopus)

CPX-351 exhibits potent and direct ex vivo cytotoxicity against AML blasts with enhanced efficacy for cells harboring the FLT3-ITD mutation

Gordon, M. J., Tardi, P., Loriaux, M., Spurgeon, S., Traer, E., Kovacsovics, T., Mayer, L. D. & Tyner, J., Feb 1 2017, In : Leukemia Research. 53, p. 39-49 11 p.

Research output: Contribution to journalArticle

Mutation
B-Cell Chronic Lymphocytic Leukemia
Inhibitory Concentration 50
Daunorubicin
Myelodysplastic Syndromes
7 Citations (Scopus)

Creation of fibrinogen-enhanced experimental blood clots to evaluate mechanical thrombectomy devices for treatment of acute stroke: An in vitro study

Luo, Z. H., Chung, A., Choi, G., Lin, Y. H., Uchida, B., Pavcnik, D., Loriaux, M., Nesbit, G., Keller, F. & Rosch, J., Aug 2012, In : Journal of Vascular and Interventional Radiology. 23, 8, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

Thrombectomy
Fibrinogen
Thrombosis
Stroke
Equipment and Supplies
94 Citations (Scopus)

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Bicocca, V. T., Chang, B., Masouleh, B. K., Muschen, M., Loriaux, M., Druker, B. & Tyner, J., Nov 13 2012, In : Cancer Cell. 22, 5, p. 656-667 12 p.

Research output: Contribution to journalArticle

Pre-B Cell Receptors
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Phosphorylation
Cell Surface Receptors
Phosphotransferases
4 Citations (Scopus)

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E., Kaempf, A., Mori, M. T., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. & Tyner, J., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Acute Myeloid Leukemia
Macrophage Colony-Stimulating Factor
Cytokines
Cells
32 Citations (Scopus)
Drug Synergism
Naphthyridines
Quinazolinones
Pyrazoles
Vidarabine
149 Citations (Scopus)

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

Tyner, J., Bumm, T. G., Deininger, J., Wood, L., Aichberger, K. J., Loriaux, M., Druker, B., Burns, C. J., Fantino, E. & Deininger, M. W., Jun 24 2010, In : Blood. 115, 25, p. 5232-5240 9 p.

Research output: Contribution to journalArticle

Janus Kinase 2
Cytokines
Neoplasms
TYK2 Kinase
Alleles
100 Citations (Scopus)
Philadelphia Chromosome
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cytogenetics
Clone Cells
Metaphase
13 Citations (Scopus)

Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression

Beer, P. A., Knapp, D. J. H. F., Miller, P. H., Kannan, N., Sloma, I., Heel, K., Babovic, S., Bulaeva, E., Rabu, G., Terry, J., Druker, B., Loriaux, M., Loeb, K. R., Radich, J. P., Erber, W. N. & Eaves, C. J., Jan 15 2015, In : Blood. 125, 3, p. 504-515 12 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic Phase
Emitter coupled logic circuits
Myeloid Cells
Blast Crisis
Disease Progression
5 Citations (Scopus)

Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma

Scott, E., Maziarz, R., Spurgeon, S., Medvedova, E., Gajewski, J., Reasor-Heard, S., Park, B., Kratz, A., Thomas, G., Loriaux, M., Cascio, M., Podolak, J., Gordon, M., Botelho, J., Stadtmauer, E., Amaravadi, R. & Vogl, D. T., Jun 26 2017, In : Haematologica. 102, 7, p. e261-e265

Research output: Contribution to journalLetter

26 Citations (Scopus)

Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

Agarwal, A., Fleischman, A. G., Petersen, C. L., MacKenzie, R., Luty, S., Loriaux, M., Druker, B., Woltjer, R. R. & Deininger, M. W., Sep 27 2012, In : Blood. 120, 13, p. 2658-2668 11 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Phosphotransferases
Leukemia
Disease control
Stem cells
47 Citations (Scopus)
Leucine Zippers
Phosphorylation
Basic-Leucine Zipper Transcription Factors
Transcriptional Activation
Proteins
15 Citations (Scopus)

Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia

Demehri, S., Corbin, A., Loriaux, M., Druker, B. & Deininger, M. W., Mar 2006, In : Experimental Hematology. 34, 3, p. 284-288 5 p.

Research output: Contribution to journalArticle

Mast-Cell Leukemia
Systemic Mastocytosis
Mastocytoma
Inbred DBA Mouse
Rare Diseases
5 Citations (Scopus)

Fallopian tube occlusion with use of a small intestine submucosa device: Evaluation in a rabbit model

Binkert, C. A., Pavcnik, D., Andrews, R. T., Loriaux, M., Uchida, B., Brountzos, E. N. & Rosch, J., Jun 2004, In : Journal of Vascular and Interventional Radiology. 15, 6, p. 609-613 5 p.

Research output: Contribution to journalArticle

Fallopian Tubes
Small Intestine
Rabbits
Equipment and Supplies
Hysterosalpingography
4 Citations (Scopus)

Functional characterization of an activating TEK mutation in acute myeloid leukemia: A cellular context-dependent activating mutation

Tyner, J., Rutenberg-Schoenberg, M. L., Erickson, H., Willis, S. G., O'Hare, T., Deininger, M. W., Druker, B. & Loriaux, M., 2009, In : Leukemia. 23, 7, p. 1345-1348 4 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Mutation
40 Citations (Scopus)

Functional genomic landscape of acute myeloid leukaemia

Tyner, J., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K-H., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M. T., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. & Druker, B., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
RNA Sequence Analysis
Pharmaceutical Preparations
Exome
Gene Regulatory Networks
9 Citations (Scopus)

High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia

Tyner, J., Loriaux, M., Erickson, H., Eide, C. A., Deininger, J., MacPartlin, M., Willis, S. G., Lange, T., Druker, B., Kovacsovics, T., Maziarz, R., Gattermann, N. & Deininger, M. W., 2009, In : Leukemia. 23, 2, p. 406-409 4 p.

Research output: Contribution to journalArticle

DNA Mutational Analysis
Leukemia, Myelomonocytic, Chronic
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Proteomics
Protein-Tyrosine Kinases
74 Citations (Scopus)

High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

Loriaux, M., Levine, R. L., Tyner, J., Fröhling, S., Scholl, C., Stoffregen, E. P., Wernig, G., Erickson, H., Eide, C. A., Berger, R., Bernard, O. A., Griffin, J. D., Stone, R. M., Lee, B., Meyerson, M., Heinrich, M., Deininger, M. W., Gilliland, D. G. & Druker, B., May 1 2008, In : Blood. 111, 9, p. 4788-4796 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Sequence Analysis
Tyrosine
Alleles
83 Citations (Scopus)

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

Tyner, J., Erickson, H., Deininger, M. W. N., Willis, S. G., Eide, C. A., Levine, R. L., Heinrich, M., Gattermann, N., Gilliland, D. G., Druker, B. & Loriaux, M., Feb 19 2009, In : Blood. 113, 8, p. 1749-1755 7 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Exons
Assays
Screening
Throughput
6 Citations (Scopus)

HitWalker: Variant prioritization for personalized functional cancer genomics

Bottomly, D., Wilmot, B., Tyner, J., Eide, C. A., Loriaux, M., Druker, B. & McWeeney, S., Feb 15 2013, In : Bioinformatics. 29, 4, p. 509-510 2 p.

Research output: Contribution to journalArticle

Prioritization
Genomics
Cancer
Program documentation
Proteins
459 Citations (Scopus)

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Corbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W. & Druker, B., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 396-409 14 p.

Research output: Contribution to journalArticle

Myeloid Progenitor Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia
Therapeutics
Survival
1 Citation (Scopus)
Myeloid Progenitor Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Imatinib Mesylate
126 Citations (Scopus)

Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles

Fröhling, S., Scholl, C., Levine, R. L., Loriaux, M., Boggon, T. J., Bernard, O. A., Berger, R., Döhner, H., Döhner, K., Ebert, B. L., Teckie, S., Golub, T. R., Jiang, J., Schittenhelm, M. M., Lee, B. H., Griffin, J. D., Stone, R. M., Heinrich, M., Deininger, M. W., Druker, B. & 1 others, Gilliland, D. G., Dec 6 2007, In : Cancer Cell. 12, 6, p. 501-513 13 p.

Research output: Contribution to journalArticle

DNA Sequence Analysis
Alleles
Mutation
Phosphotransferases
Catalytic Domain
18 Citations (Scopus)

Imatinib and dasatinib inhibit hemangiosarcoma and implicate PDGFR-β and Src in tumor growth

Dickerson, E. B., Marley, K., Edris, W., Tyner, J., Schalk, V., MacDonald, V., Loriaux, M., Druker, B. & Helfand, S. C., Apr 2013, In : Translational Oncology. 6, 2, p. 158-168 11 p.

Research output: Contribution to journalArticle

Hemangiosarcoma
Protein-Tyrosine Kinases
Growth
Neoplasms
Phosphorylation
14 Citations (Scopus)
Gene Rearrangement
Precursor Cell Lymphoblastic Leukemia-Lymphoma
B-Lymphoid Precursor Cells
Stem Cells
Therapeutics
86 Citations (Scopus)

Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening

Tyner, J., Yang, W. F., Bankhead, A., Fan, G., Fletcher, L. B., Bryant, J., Glover, J. M., Chang, B., Spurgeon, S., Fleming, W., Kovacsovics, T., Gotlib, J. R., Oh, S. T., Deininger, M. W., Zwaan, C. M., Den Boer, M. L., Van Den Heuvel-Eibrink, M. M., O'Hare, T., Druker, B. & Loriaux, M., Jan 1 2013, In : Cancer Research. 73, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

Leukemia
Phosphotransferases
Pharmaceutical Preparations
High-Throughput Nucleotide Sequencing
Mutation
4 Citations (Scopus)

Lack of suitability of the rabbit model for particulate uterine artery embolization

Binkert, C. A., Andrews, R. T., Pavcnik, D., Uchida, B., Loriaux, M., Toyota, N. & Rosch, J., 2002, In : Journal of Vascular and Interventional Radiology. 13, 6, p. 609-612 4 p.

Research output: Contribution to journalArticle

Uterine Artery Embolization
Rabbits
Polyvinyl Alcohol
Uterine Artery
Pregnancy
54 Citations (Scopus)

MET receptor sequence variants R970C and T992I lack transforming capacity

Tyner, J., Fletcher, L. B., Wang, E. Q., Yang, W. F., Rutenberg-Schoenberg, M. L., Beadling, C., Mori, M. T., Heinrich, M., Deininger, M. W., Druker, B. & Loriaux, M., Aug 1 2010, In : Cancer Research. 70, 15, p. 6233-6237 5 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Leukemia, Myelomonocytic, Chronic
Proto-Oncogene Proteins c-met
Mutation
Poisons
32 Citations (Scopus)

Modulatory function of CREB·CREMα heterodimers depends upon CREMα phosphorylation

Loriaux, M., Brennan, R. G. & Goodman, R., Nov 18 1994, In : Journal of Biological Chemistry. 269, 46, p. 28839-28843 5 p.

Research output: Contribution to journalArticle

Phosphorylation
Cyclic AMP-Dependent Protein Kinases
Carrier Proteins
Chemical activation
Proteins
14 Citations (Scopus)

Multiplex high-throughput gene mutation analysis in acute myeloid leukemia

Dunlap, J., Beadling, C., Warrick, A., Neff, T., Fleming, W., Loriaux, M., Heinrich, M., Kovacsovics, T., Kelemen, K., Leeborg, N., Gatter, K., Braziel, R., Press, R., Corless, C. & Fan, G., Dec 2012, In : Human Pathology. 43, 12, p. 2167-2176 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Mutation
Cytogenetics
Genes
Leukemia
41 Citations (Scopus)

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia

Bains, T., Heinrich, M., Loriaux, M., Beadling, C., Nelson, D., Warrick, A., Neff, T. L., Tyner, J., Dunlap, J., Corless, C. & Fan, G., Sep 2012, In : Leukemia. 26, 9, p. 2144-2146 3 p.

Research output: Contribution to journalArticle

Janus Kinase 3
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Mutation
262 Citations (Scopus)

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

Maxson, J., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., Bottomly, D., Wilmot, B., McWeeney, S., Tognon, C. E., Pond, J. B., Collins, R. H., Goueli, B., Stephen, T. O., Michael, W. D., Chang, B., Loriaux, M., Druker, B. & Tyner, J., 2013, In : New England Journal of Medicine. 368, 19, p. 1781-1790 10 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Leukemia, Neutrophilic, Chronic
Mutation
Phosphotransferases
Neoplasms