Marc Loriaux

Associate Professor

  • 5378 Citations
  • 33 h-Index
1991 …2020

Research output per year

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Research Output

  • 5378 Citations
  • 33 h-Index
  • 67 Article
  • 7 Letter
  • 1 Comment/debate
  • 1 Review article

A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

Johnson, K. J., Griswold, I. J., O'Hare, T., Corbin, A. S., Loriaux, M., Deininger, M. W. & Druker, B. J., 2009, In : PloS one. 4, 10, e0007439.

Research output: Contribution to journalArticle

21 Scopus citations

Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

Agarwal, A., Bumm, T. G. P., Corbin, A. S., O'Hare, T., Loriaux, M., Van Dyke, J., Willis, S. G., Deininger, J., Nakayama, K. I., Druker, B. J. & Deininger, M. W., Sep 1 2008, In : Blood. 112, 5, p. 1960-1970 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

A case study of personalized therapy for osteosarcoma

Davis, L. E., Hofmann, N. E., Li, G., Huang, E. T., Loriaux, M. M., Bracha, S., Helfand, S. C., Mata, J. E., Marley, K., Mansoor, A., Tyner, J. W., Abraham, J., Séguin, B. & Keller, C., Aug 1 2013, In : Pediatric Blood and Cancer. 60, 8, p. 1313-1319 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Activating alleles of JAK3 in acute megakaryoblastic leukemia

Walters, D. K., Mercher, T., Gu, T. L., O'Hare, T., Tyner, J. W., Loriaux, M., Goss, V. L., Lee, K. A., Eide, C. A., Wong, M. J., Stoffregen, E. P., McGreevey, L., Nardone, J., Moore, S. A., Crispino, J., Boggon, T. J., Heinrich, M. C., Deininger, M. W., Polakiewicz, R. D., Gilliland, D. G. & 1 others, Druker, B. J., Jul 1 2006, In : Cancer Cell. 10, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

245 Scopus citations

Acute graft-versus-host disease of the heart

Roberts, S. S., Leeborg, N., Loriaux, M., Johnson, F. L., Huang, M. L., Stenzel, P., Thiede, C. & Godder, K. T., Oct 15 2006, In : Pediatric Blood and Cancer. 47, 5, p. 624-628 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib

McWeeney, S. K., Pemberton, L. C., Loriaux, M. M., Vartanian, K., Willis, S. G., Yochum, G., Wilmot, B., Turpaz, Y., Pillai, R., Druker, B. J., Snead, J. L., MacPartlin, M., O'Brien, S. G., Melo, J. V., Lange, T., Harrington, C. A. & Deininger, M. W. N., Jan 14 2010, In : Blood. 115, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

85 Scopus citations
28 Scopus citations

An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma

Abraham, J., Chua, Y. X., Glover, J. M., Tyner, J. W., Loriaux, M. M., Kilcoyne, A., Giles, F. J., Nelon, L. D., Carew, J. S., Ouyang, Y., Michalek, J. E., Pal, R., Druker, B. J., Rubin, B. P. & Keller, C., Sep 28 2012, In : Biochemical and Biophysical Research Communications. 426, 3, p. 363-368 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

O'Hare, T., Shakespeare, W. C., Zhu, X., Eide, C. A., Rivera, V. M., Wang, F., Adrian, L. T., Zhou, T., Huang, W. S., Xu, Q., Metcalf, C. A., Tyner, J. W., Loriaux, M. M., Corbin, A. S., Wardwell, S., Ning, Y., Keats, J. A., Wang, Y., Sundaramoorthi, R., Thomas, M. & 8 others, Zhou, D., Snodgrass, J., Commodore, L., Sawyer, T. K., Dalgarno, D. C., Deininger, M. W. N., Druker, B. J. & Clackson, T., Nov 6 2009, In : Cancer Cell. 16, 5, p. 401-412 12 p.

Research output: Contribution to journalArticle

727 Scopus citations

A potential therapeutic strategy for chronic lymphocytic leukemia by combining idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor

Burke, R. T., Meadows, S., Loriaux, M. M., Currie, K. S., Mitchell, S. A., Maciejewski, P., Clarke, A. S., Dipaolo, J. A., Druker, B. J., Lannutti, B. J. & Spurgeon, S. E., 2014, In : Oncotarget. 5, 4, p. 908-915 8 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations
8 Scopus citations

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

Agarwal, A., Mackenzie, R. J., Besson, A., Jeng, S., Carey, A., LaTocha, D. H., Fleischman, A. G., Duquesnes, N., Eide, C. A., Vasudevan, K. B., Loriaux, M. M., Firpo, E., Cortes, J. E., McWeeney, S., O'Hare, T., Roberts, J. M., Druker, B. J. & Deininger, M. W., Nov 20 2014, In : Blood. 124, 22, p. 3260-3273 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Bifurcated drum occluder endograft for treatment of abdominal aortic aneurysm: An experimental study in dogs

Pavcnik, D., Uchida, B. T., Timmermans, H., Petersen, B., Loriaux, M., Yamakado, K., Voda, J., Yin, Q., Keller, F. S. & Rösch, J., Jan 1 2001, In : Journal of Vascular and Interventional Radiology. 12, 3, p. 359-364 6 p., 61917.

Research output: Contribution to journalArticle

7 Scopus citations

CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Lannutti, B. J., Meadows, S. A., Herman, S. E. M., Kashishian, A., Steiner, B., Johnson, A. J., Byrd, J. C., Tyner, J. W., Loriaux, M. M., Deininger, M., Druker, B. J., Puri, K. D., Ulrich, R. G. & Giese, N. A., Jan 13 2011, In : Blood. 117, 2, p. 591-594 4 p.

Research output: Contribution to journalArticle

526 Scopus citations

c-CBL is not required for leukemia induction by Bcr-Abl in mice

Dinulescu, D. M., Wood, L. J., Shen, L., Loriaux, M., Corless, C. L., Gross, A. W., Ren, R., Deininger, M. W. N. & Druker, B. J., Dec 4 2003, In : Oncogene. 22, 55, p. 8852-8860 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization of murine JAK2V617F-positive myeloproliferative disease

Bumm, T. G. P., Elsea, C., Corbin, A. S., Loriaux, M., Sherbenou, D., Wood, L., Deininger, J., Silver, R. T., Druker, B. J. & Deininger, M. W. N., Dec 1 2006, In : Cancer Research. 66, 23, p. 11156-11165 10 p.

Research output: Contribution to journalArticle

154 Scopus citations

Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib

Loriaux, M. & Deininger, M., Nov 1 2004, In : Leukemia and Lymphoma. 45, 11, p. 2197-2203 7 p.

Research output: Contribution to journalReview article

62 Scopus citations
4 Scopus citations

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Huan, J., Hornick, N. I., Goloviznina, N. A., Kamimae-Lanning, A. N., David, L., Wilmarth, P., Mori, M. T., Chevillet, J. R., Narla, A., Roberts, C., Loriaux, M., Chang, B. & Kurre, P., Jun 25 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

46 Scopus citations

CPX-351 exhibits potent and direct ex vivo cytotoxicity against AML blasts with enhanced efficacy for cells harboring the FLT3-ITD mutation

Gordon, M. J., Tardi, P., Loriaux, M., Spurgeon, S., Traer, E., Kovacsovics, T., Mayer, L. D. & Tyner, J., Feb 1 2017, In : Leukemia Research. 53, p. 39-49 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Creation of fibrinogen-enhanced experimental blood clots to evaluate mechanical thrombectomy devices for treatment of acute stroke: An in vitro study

Luo, Z. H., Chung, A., Choi, G., Lin, Y. H., Uchida, B. T., Pavcnik, D., Loriaux, M. M., Nesbit, G. M., Keller, F. S. & Rösch, J., Aug 1 2012, In : Journal of Vascular and Interventional Radiology. 23, 8, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Bicocca, V. T., Chang, B. H., Masouleh, B. K., Muschen, M., Loriaux, M. M., Druker, B. J. & Tyner, J. W., Nov 13 2012, In : Cancer Cell. 22, 5, p. 656-667 12 p.

Research output: Contribution to journalArticle

100 Scopus citations

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E. F., Kaempf, A., Mori, M., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. K. & Tyner, J. W., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

Tyner, J. W., Bumm, T. G., Deininger, J., Wood, L., Aichberger, K. J., Loriaux, M. M., Druker, B. J., Burns, C. J., Fantino, E. & Deininger, M. W., Jun 24 2010, In : Blood. 115, 25, p. 5232-5240 9 p.

Research output: Contribution to journalArticle

159 Scopus citations
100 Scopus citations

Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression

Beer, P. A., Knapp, D. J. H. F., Miller, P. H., Kannan, N., Sloma, I., Heel, K., Babovic, S., Bulaeva, E., Rabu, G., Terry, J., Druker, B. J., Loriaux, M. M., Loeb, K. R., Radich, J. P., Erber, W. N. & Eaves, C. J., Jan 15 2015, In : Blood. 125, 3, p. 504-515 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma

Scott, E., Maziarz, R., Spurgeon, S., Medvedova, E., Gajewski, J., Reasor-Heard, S., Park, B., Kratz, A., Thomas, G., Loriaux, M., Cascio, M., Podolak, J., Gordon, M., Botelho, J., Stadtmauer, E., Amaravadi, R. & Vogl, D. T., Jun 26 2017, In : Haematologica. 102, 7, p. e261-e265

Research output: Contribution to journalLetter

5 Scopus citations

Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

Agarwal, A., Fleischman, A. G., Petersen, C. L., MacKenzie, R., Luty, S., Loriaux, M., Druker, B. J., Woltjer, R. L. & Deininger, M. W., Sep 27 2012, In : Blood. 120, 13, p. 2658-2668 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
Open Access
48 Scopus citations

Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia

Demehri, S., Corbin, A., Loriaux, M., Druker, B. J. & Deininger, M. W., Mar 1 2006, In : Experimental hematology. 34, 3, p. 284-288 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Fallopian tube occlusion with use of a small intestine submucosa device: Evaluation in a rabbit model

Binkert, C. A., Pavcnik, D., Andrews, R. T., Loriaux, M. M., Uchida, B., Brountzos, E. N. & Rösch, J., Jun 2004, In : Journal of Vascular and Interventional Radiology. 15, 6, p. 609-613 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Functional characterization of an activating TEK mutation in acute myeloid leukemia: A cellular context-dependent activating mutation

Tyner, J. W., Rutenberg-Schoenberg, M. L., Erickson, H., Willis, S. G., O'Hare, T., Deininger, M. W., Druker, B. J. & Loriaux, M. M., Jan 1 2009, In : Leukemia. 23, 7, p. 1345-1348 4 p.

Research output: Contribution to journalLetter

4 Scopus citations

Functional genomic landscape of acute myeloid leukaemia

Tyner, J. W., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B. H., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K. H. T., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M. M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S. E., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. K. & Druker, B. J., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

122 Scopus citations

High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia

Tyner, J. W., Loriaux, M. M., Erickson, H., Eide, C. A., Deininger, J., MacPartlin, M., Willis, S. G., Lange, T., Druker, B. J., Kovacsovics, T., Maziarz, R., Gattermann, N. & Deininger, M. W., Jan 1 2009, In : Leukemia. 23, 2, p. 406-409 4 p.

Research output: Contribution to journalLetter

9 Scopus citations

High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

Loriaux, M. M., Levine, R. L., Tyner, J. W., Fröhling, S., Scholl, C., Stoffregen, E. P., Wernig, G., Erickson, H., Eide, C. A., Berger, R., Bernard, O. A., Griffin, J. D., Stone, R. M., Lee, B., Meyerson, M., Heinrich, M. C., Deininger, M. W., Gilliland, D. G. & Druker, B. J., May 1 2008, In : Blood. 111, 9, p. 4788-4796 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

Tyner, J. W., Erickson, H., Deininger, M. W. N., Willis, S. G., Eide, C. A., Levine, R. L., Heinrich, M. C., Gattermann, N., Gilliland, D. G., Druker, B. J. & Loriaux, M. M., Feb 19 2009, In : Blood. 113, 8, p. 1749-1755 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

HitWalker: Variant prioritization for personalized functional cancer genomics

Bottomly, D., Wilmot, B., Tyner, J. W., Eide, C. A., Loriaux, M. M., Druker, B. J. & McWeeney, S. K., Feb 15 2013, In : Bioinformatics. 29, 4, p. 509-510 2 p.

Research output: Contribution to journalArticle

7 Scopus citations

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Corbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W. & Druker, B. J., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 396-409 14 p.

Research output: Contribution to journalArticle

505 Scopus citations

Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles

Fröhling, S., Scholl, C., Levine, R. L., Loriaux, M., Boggon, T. J., Bernard, O. A., Berger, R., Döhner, H., Döhner, K., Ebert, B. L., Teckie, S., Golub, T. R., Jiang, J., Schittenhelm, M. M., Lee, B. H., Griffin, J. D., Stone, R. M., Heinrich, M. C., Deininger, M. W., Druker, B. J. & 1 others, Gilliland, D. G., Dec 6 2007, In : Cancer Cell. 12, 6, p. 501-513 13 p.

Research output: Contribution to journalArticle

133 Scopus citations

Imatinib and dasatinib inhibit hemangiosarcoma and implicate PDGFR-β and Src in tumor growth

Dickerson, E. B., Marley, K., Edris, W., Tyner, J. W., Schalk, V., MacDonald, V., Loriaux, M., Druker, B. J. & Helfand, S. C., Apr 2013, In : Translational Oncology. 6, 2, p. 158-168 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
15 Scopus citations

Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening

Tyner, J. W., Yang, W. F., Bankhead, A., Fan, G., Fletcher, L. B., Bryant, J., Glover, J. M., Chang, B. H., Spurgeon, S. E., Fleming, W. H., Kovacsovics, T., Gotlib, J. R., Oh, S. T., Deininger, M. W., Zwaan, C. M., Den Boer, M. L., Van Den Heuvel-Eibrink, M. M., O'Hare, T., Druker, B. J. & Loriaux, M. M., Jan 1 2013, In : Cancer Research. 73, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

91 Scopus citations

Lack of suitability of the rabbit model for particulate uterine artery embolization

Binkert, C. A., Andrews, R. T., Pavcnik, D., Uchida, B., Loriaux, M. M., Toyota, N. & Rösch, J., Jan 1 2002, In : Journal of Vascular and Interventional Radiology. 13, 6, p. 609-612 4 p., 61655.

Research output: Contribution to journalArticle

4 Scopus citations

Mast cell sarcoma with concurrent mast cell leukaemia

Raymond, L. M., Funk, T., Braziel, R. M., Fan, G., Gatter, K., Loriaux, M., Dunlap, J. & Raess, P. W., May 1 2020, In : British Journal of Haematology. 189, 4, p. e160-e164

Research output: Contribution to journalLetter

Open Access

MET receptor sequence variants R970C and T992I lack transforming capacity

Tyner, J. W., Fletcher, L. B., Wang, E. Q., Yang, W. F., Rutenberg-Schoenberg, M. L., Beadling, C., Mori, M., Heinrich, M. C., Deininger, M. W., Druker, B. J. & Loriaux, M. M., Aug 1 2010, In : Cancer Research. 70, 15, p. 6233-6237 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Modulatory function of CREB·CREMα heterodimers depends upon CREMα phosphorylation

Loriaux, M. M., Brennan, R. G. & Goodman, R. H., Nov 18 1994, In : Journal of Biological Chemistry. 269, 46, p. 28839-28843 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Multiplex high-throughput gene mutation analysis in acute myeloid leukemia

Dunlap, J., Beadling, C., Warrick, A., Neff, T., Fleming, W. H., Loriaux, M., Heinrich, M. C., Kovacsovics, T., Kelemen, K., Leeborg, N., Gatter, K., Braziel, R. M., Press, R., Corless, C. L. & Fan, G., Dec 1 2012, In : Human Pathology. 43, 12, p. 2167-2176 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia

Bains, T., Heinrich, M. C., Loriaux, M. M., Beadling, C., Nelson, D., Warrick, A., Neff, T. L., Tyner, J. W., Dunlap, J., Corless, C. L. & Fan, G., Sep 1 2012, In : Leukemia. 26, 9, p. 2144-2146 3 p.

Research output: Contribution to journalLetter

44 Scopus citations