Marc Loriaux

Associate Professor

  • 4998 Citations
  • 32 h-Index
1991 …2019
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Research Output 1991 2019

  • 4998 Citations
  • 32 h-Index
  • 73 Article
  • 1 Letter
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Article
2019
5 Citations (Scopus)

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E., Kaempf, A., Mori, M. T., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. & Tyner, J., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Acute Myeloid Leukemia
Macrophage Colony-Stimulating Factor
Cytokines
Cells
2018
48 Citations (Scopus)

Functional genomic landscape of acute myeloid leukaemia

Tyner, J., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K-H., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M. T., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. & Druker, B., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
RNA Sequence Analysis
Pharmaceutical Preparations
Exome
Gene Regulatory Networks

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

Jenkins, C., Luty, S. B., Maxson, J., Eide, C. A., Abel, M. L., Togiai, C., Nemecek, E., Bottomly, D., McWeeney, S., Wilmot, B., Loriaux, M., Chang, B. & Tyner, J., Jul 17 2018, In : Science Signaling. 11, 539, eaao5617.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Leukemia
Acute Myeloid Leukemia
Myeloid Cells
Mitogen-Activated Protein Kinases
6 Citations (Scopus)

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A., Lee, P., Chantry, D., McWeeney, S., Druker, B., Tyner, J., Spurgeon, S. & Loriaux, M., May 15 2018, In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
B-Cell Chronic Lymphocytic Leukemia
Antineoplastic Agents
Monocytes
2017
13 Citations (Scopus)

CPX-351 exhibits potent and direct ex vivo cytotoxicity against AML blasts with enhanced efficacy for cells harboring the FLT3-ITD mutation

Gordon, M. J., Tardi, P., Loriaux, M., Spurgeon, S., Traer, E., Kovacsovics, T., Mayer, L. D. & Tyner, J., Feb 1 2017, In : Leukemia Research. 53, p. 39-49 11 p.

Research output: Contribution to journalArticle

Mutation
B-Cell Chronic Lymphocytic Leukemia
Inhibitory Concentration 50
Daunorubicin
Myelodysplastic Syndromes
4 Citations (Scopus)

SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia

Paiva, C., Rowland, T. A., Sreekantham, B., Godbersen, C., Best, S. R., Kaur, P., Loriaux, M., Spurgeon, S., Danilova, O. V. & Danilov, A., Oct 27 2017, In : Haematologica. 102, 11, p. 1890-1900 11 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
TNF Receptor-Associated Factor 3
Phosphotransferases
TNF Receptor-Associated Factor 2
2016
22 Citations (Scopus)
Neoplasm Drug Resistance
Exosomes
Protein Kinase Inhibitors
MicroRNAs
Mesenchymal Stromal Cells
26 Citations (Scopus)

Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia

Leonard, J. T., Rowley, J. S. J., Eide, C. A., Traer, E., Hayes-Lattin, B., Loriaux, M., Spurgeon, S., Druker, B., Tyner, J. & Chang, B., Aug 31 2016, In : Science Translational Medicine. 8, 354, 354ra114.

Research output: Contribution to journalArticle

Philadelphia Chromosome
B-Cell Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Therapeutics
21 Citations (Scopus)

The colony-Stimulating factor 3 receptor T640N mutation is oncogenic, sensitive toJAKInhibition, and mimics T618i

Maxson, J., Luty, S. B., MacManiman, J. D., Paik, J. C., Gotlib, J., Greenberg, P., Bahamadi, S., Savage, S. L., Abel, M. L., Eide, C. A., Loriaux, M., Stevens, E. A. & Tyner, J., Feb 1 2016, In : Clinical Cancer Research. 22, 3, p. 757-764 8 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Leukemia, Neutrophilic, Chronic
Mutation
Janus Kinases
2015
38 Citations (Scopus)

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Huan, J., Hornick, N. I., Goloviznina, N. A., Kamimae-Lanning, A. N., David, L., Wilmarth, P., Mori, M. T., Chevillet, J. R., Narla, A., Roberts, C., Loriaux, M., Chang, B. & Kurre, P., Jun 25 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Exosomes
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Bone Marrow
Exosome Multienzyme Ribonuclease Complex
13 Citations (Scopus)

Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression

Beer, P. A., Knapp, D. J. H. F., Miller, P. H., Kannan, N., Sloma, I., Heel, K., Babovic, S., Bulaeva, E., Rabu, G., Terry, J., Druker, B., Loriaux, M., Loeb, K. R., Radich, J. P., Erber, W. N. & Eaves, C. J., Jan 15 2015, In : Blood. 125, 3, p. 504-515 12 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic Phase
Emitter coupled logic circuits
Myeloid Cells
Blast Crisis
Disease Progression
30 Citations (Scopus)
Melphalan
Pharmaceutical Preparations
Multiple Myeloma
Cell Line
Bortezomib
8 Citations (Scopus)

Therapeutically targetable ALK mutations in leukemia

Maxson, J., Davare, M., Luty, S. B., Eide, C. A., Chang, B., Loriaux, M., Tognon, C. E., Bottomly, D., Wilmot, B., McWeeney, S., Druker, B. & Tyner, J., Jun 1 2015, In : Cancer Research. 75, 11, p. 2146-2150 5 p.

Research output: Contribution to journalArticle

Leukemia
Mutation
Phosphotransferases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Point Mutation
13 Citations (Scopus)

YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

Chang, B., Johnson, K., LaTocha, D., Rowley, J. S. J., Bryant, J., Burke, R., Smith, R. L., Loriaux, M., Müschen, M., Mullighan, C., Druker, B. & Tyner, J., Apr 22 2015, In : Journal of Hematology and Oncology. 8, 1, 39.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA Damage
S Phase
Phosphorylation
Cell Line
2014
40 Citations (Scopus)

A potential therapeutic strategy for chronic lymphocytic leukemia by combining idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor

Burke, R. T., Meadows, S., Loriaux, M., Currie, K. S., Mitchell, S. A., Maciejewski, P., Clarke, A. S., Dipaolo, J. A., Druker, B., Lannutti, B. J. & Spurgeon, S., 2014, In : Oncotarget. 5, 4, p. 908-915 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Bone Marrow
Disease Eradication
Therapeutics
15 Citations (Scopus)

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

Agarwal, A., Mackenzie, R. J., Besson, A., Jeng, S., Carey, A., LaTocha, D. H., Fleischman, A. G., Duquesnes, N., Eide, C. A., Vasudevan, K. B., Loriaux, M., Firpo, E., Cortes, J. E., McWeeney, S., O'Hare, T., Roberts, J. M., Druker, B. & Deininger, M. W., Nov 20 2014, In : Blood. 124, 22, p. 3260-3273 14 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tumors
Leukemia
Cyclin-Dependent Kinases
2013
14 Citations (Scopus)

A case study of personalized therapy for osteosarcoma

Davis, L., Hofmann, N. E., Li, G., Huang, E. T., Loriaux, M., Bracha, S., Helfand, S. C., Mata, J. E., Marley, K., Mansoor, A., Tyner, J., Abraham, J., Séguin, B. & Keller, C., Aug 2013, In : Pediatric Blood and Cancer. 60, 8, p. 1313-1319 7 p.

Research output: Contribution to journalArticle

Osteosarcoma
Sarcoma
Canidae
Neoplasms
Therapeutics
4 Citations (Scopus)
Precision Medicine
Genes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Small Interfering RNA
Genome
32 Citations (Scopus)
Drug Synergism
Naphthyridines
Quinazolinones
Pyrazoles
Vidarabine
6 Citations (Scopus)

HitWalker: Variant prioritization for personalized functional cancer genomics

Bottomly, D., Wilmot, B., Tyner, J., Eide, C. A., Loriaux, M., Druker, B. & McWeeney, S., Feb 15 2013, In : Bioinformatics. 29, 4, p. 509-510 2 p.

Research output: Contribution to journalArticle

Prioritization
Genomics
Cancer
Program documentation
Proteins
18 Citations (Scopus)

Imatinib and dasatinib inhibit hemangiosarcoma and implicate PDGFR-β and Src in tumor growth

Dickerson, E. B., Marley, K., Edris, W., Tyner, J., Schalk, V., MacDonald, V., Loriaux, M., Druker, B. & Helfand, S. C., Apr 2013, In : Translational Oncology. 6, 2, p. 158-168 11 p.

Research output: Contribution to journalArticle

Hemangiosarcoma
Protein-Tyrosine Kinases
Growth
Neoplasms
Phosphorylation
87 Citations (Scopus)

Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening

Tyner, J., Yang, W. F., Bankhead, A., Fan, G., Fletcher, L. B., Bryant, J., Glover, J. M., Chang, B., Spurgeon, S., Fleming, W., Kovacsovics, T., Gotlib, J. R., Oh, S. T., Deininger, M. W., Zwaan, C. M., Den Boer, M. L., Van Den Heuvel-Eibrink, M. M., O'Hare, T., Druker, B. & Loriaux, M., Jan 1 2013, In : Cancer Research. 73, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

Leukemia
Phosphotransferases
Pharmaceutical Preparations
High-Throughput Nucleotide Sequencing
Mutation
265 Citations (Scopus)

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

Maxson, J., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., Bottomly, D., Wilmot, B., McWeeney, S., Tognon, C. E., Pond, J. B., Collins, R. H., Goueli, B., Stephen, T. O., Michael, W. D., Chang, B., Loriaux, M., Druker, B. & Tyner, J., 2013, In : New England Journal of Medicine. 368, 19, p. 1781-1790 10 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Leukemia, Neutrophilic, Chronic
Mutation
Phosphotransferases
Neoplasms
55 Citations (Scopus)

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in Mice that is responsive to therapeutic JAK inhibition

Fleischman, A. G., Maxson, J., Luty, S. B., Agarwal, A., Royer, L. R., Abel, M. L., Macmaniman, J. D., Loriaux, M., Druker, B. & Tyner, J., Nov 21 2013, In : Blood. 122, 22, p. 3628-3631 4 p.

Research output: Contribution to journalArticle

Myeloproliferative Disorders
Leukemia, Neutrophilic, Chronic
Mutation
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Spleen
31 Citations (Scopus)

The selective syk inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemias

Spurgeon, S., Coffey, G., Fletcher, L. B., Burke, R., Tyner, J., Druker, B., Betz, A., DeGuzman, F., Pak, Y., Baker, D., Pandey, A., Hollenbach, S. J., Sinha, U. & Loriaux, M., Feb 2013, In : Journal of Pharmacology and Experimental Therapeutics. 344, 2, p. 378-387 10 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Non-Hodgkin's Lymphoma
Phosphotransferases
Neoplasms
2012
10 Citations (Scopus)

An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma

Abraham, J., Chua, Y. X., Glover, J. M., Tyner, J., Loriaux, M., Kilcoyne, A., Giles, F. J., Nelon, L. D., Carew, J. S., Ouyang, Y., Michalek, J. E., Pal, R., Druker, B., Rubin, B. P. & Keller, C., Sep 28 2012, In : Biochemical and Biophysical Research Communications. 426, 3, p. 363-368 6 p.

Research output: Contribution to journalArticle

Alveolar Rhabdomyosarcoma
Rhabdomyosarcoma
Tumors
Cell culture
Primary Cell Culture
7 Citations (Scopus)

Creation of fibrinogen-enhanced experimental blood clots to evaluate mechanical thrombectomy devices for treatment of acute stroke: An in vitro study

Luo, Z. H., Chung, A., Choi, G., Lin, Y. H., Uchida, B., Pavcnik, D., Loriaux, M., Nesbit, G., Keller, F. & Rosch, J., Aug 2012, In : Journal of Vascular and Interventional Radiology. 23, 8, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

Thrombectomy
Fibrinogen
Thrombosis
Stroke
Equipment and Supplies
95 Citations (Scopus)

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Bicocca, V. T., Chang, B., Masouleh, B. K., Muschen, M., Loriaux, M., Druker, B. & Tyner, J., Nov 13 2012, In : Cancer Cell. 22, 5, p. 656-667 12 p.

Research output: Contribution to journalArticle

Pre-B Cell Receptors
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Phosphorylation
Cell Surface Receptors
Phosphotransferases
26 Citations (Scopus)

Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

Agarwal, A., Fleischman, A. G., Petersen, C. L., MacKenzie, R., Luty, S., Loriaux, M., Druker, B., Woltjer, R. R. & Deininger, M. W., Sep 27 2012, In : Blood. 120, 13, p. 2658-2668 11 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Phosphotransferases
Leukemia
Disease control
Stem cells
14 Citations (Scopus)
Gene Rearrangement
Precursor Cell Lymphoblastic Leukemia-Lymphoma
B-Lymphoid Precursor Cells
Stem Cells
Therapeutics
15 Citations (Scopus)

Multiplex high-throughput gene mutation analysis in acute myeloid leukemia

Dunlap, J., Beadling, C., Warrick, A., Neff, T., Fleming, W., Loriaux, M., Heinrich, M., Kovacsovics, T., Kelemen, K., Leeborg, N., Gatter, K., Braziel, R., Press, R., Corless, C. & Fan, G., Dec 2012, In : Human Pathology. 43, 12, p. 2167-2176 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Mutation
Cytogenetics
Genes
Leukemia
42 Citations (Scopus)

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia

Bains, T., Heinrich, M., Loriaux, M., Beadling, C., Nelson, D., Warrick, A., Neff, T. L., Tyner, J., Dunlap, J., Corless, C. & Fan, G., Sep 2012, In : Leukemia. 26, 9, p. 2144-2146 3 p.

Research output: Contribution to journalArticle

Janus Kinase 3
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Mutation
36 Citations (Scopus)

TSLP signaling network revealed by SILAC-based phosphoproteomics.

Zhong, J., Kim, M. S., Chaerkady, R., Wu, X., Huang, T. C., Getnet, D., Mitchell, C. J., Palapetta, S. M., Sharma, J., O'Meally, R. N., Cole, R. N., Yoda, A., Moritz, A., Loriaux, M., Rush, J., Weinstock, D. M., Tyner, J. & Pandey, A., Jun 2012, In : Molecular & cellular proteomics : MCP. 11, 6

Research output: Contribution to journalArticle

Isotope Labeling
thymic stromal lymphopoietin
Phosphorylation
src-Family Kinases
Cell culture
2011
7 Citations (Scopus)
Chromosome Aberrations
Chromosomes, Human, Pair 7
Cytogenetics
Mutation
Philadelphia Chromosome
506 Citations (Scopus)

CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Lannutti, B. J., Meadows, S. A., Herman, S. E. M., Kashishian, A., Steiner, B., Johnson, A. J., Byrd, J. C., Tyner, J., Loriaux, M., Deininger, M., Druker, B., Puri, K. D., Ulrich, R. G. & Giese, N. A., Jan 13 2011, In : Blood. 117, 2, p. 591-594 4 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Phosphatidylinositol 3-Kinases
B-Lymphocytes
Cells
Neoplasms
464 Citations (Scopus)

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Corbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W. & Druker, B., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 396-409 14 p.

Research output: Contribution to journalArticle

Myeloid Progenitor Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia
Therapeutics
Survival
1 Citation (Scopus)
Myeloid Progenitor Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Imatinib Mesylate
90 Citations (Scopus)

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies

Gozgit, J. M., Wong, M. J., Wardwell, S., Tyner, J., Loriaux, M., Mohemmad, Q. K., Narasimhan, N. I., Shakespeare, W. C., Wang, F., Druker, B., Clackson, T. & Rivera, V. M., Jun 2011, In : Molecular Cancer Therapeutics. 10, 6, p. 1028-1035 8 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Acute Myeloid Leukemia
Receptor, Fibroblast Growth Factor, Type 1
Platelet-Derived Growth Factor Receptors
Inhibitory Concentration 50
35 Citations (Scopus)

Survey of activated FLT3 signaling in leukemia

Gu, T. L., Nardone, J., Wang, Y., Loriaux, M., Villén, J., Beausoleil, S., Tucker, M., Kornhauser, J., Ren, J., MacNeill, J., Gygi, S. P., Druker, B., Heinrich, M., Rush, J. & Polakiewicz, R. D., 2011, In : PLoS One. 6, 4, e19169.

Research output: Contribution to journalArticle

leukemia
Protein-Tyrosine Kinases
tyrosine
Leukemia
phosphotransferases (kinases)
113 Citations (Scopus)

TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

Fleischman, A. G., Aichberger, K. J., Luty, S. B., Bumm, T. G., Petersen, C. L., Doratotaj, S., Vasudevan, K. B., LaTocha, D. H., Yang, F., Press, R., Loriaux, M., Pahl, H. L., Silver, R. T., Agarwal, A., O'Hare, T., Druker, B., Bagby, G. C. & Deininger, M. W., Dec 8 2011, In : Blood. 118, 24, p. 6392-6398 7 p.

Research output: Contribution to journalArticle

Cells
Stem cells
Stem Cells
Assays
Neoplasms
2010
79 Citations (Scopus)

A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib

McWeeney, S., Pemberton, L. C., Loriaux, M., Vartanian, K., Willis, S. G., Yochum, G., Wilmot, B., Turpaz, Y., Pillai, R., Druker, B., Snead, J. L., MacPartlin, M., O'Brien, S. G., Melo, J. V., Lange, T., Harrington, C. C. & Deininger, M. W. N., Jan 14 2010, In : Blood. 115, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic Phase
Transcriptome
Gene expression
Cytogenetics
Classifiers
149 Citations (Scopus)

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

Tyner, J., Bumm, T. G., Deininger, J., Wood, L., Aichberger, K. J., Loriaux, M., Druker, B., Burns, C. J., Fantino, E. & Deininger, M. W., Jun 24 2010, In : Blood. 115, 25, p. 5232-5240 9 p.

Research output: Contribution to journalArticle

Janus Kinase 2
Cytokines
Neoplasms
TYK2 Kinase
Alleles
54 Citations (Scopus)

MET receptor sequence variants R970C and T992I lack transforming capacity

Tyner, J., Fletcher, L. B., Wang, E. Q., Yang, W. F., Rutenberg-Schoenberg, M. L., Beadling, C., Mori, M. T., Heinrich, M., Deininger, M. W., Druker, B. & Loriaux, M., Aug 1 2010, In : Cancer Research. 70, 15, p. 6233-6237 5 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Leukemia, Myelomonocytic, Chronic
Proto-Oncogene Proteins c-met
Mutation
Poisons

Small intestinal submucosa plug for closure of dilated nephrostomy tracts: A pilot study in swine

Kakizawa, H., Conlin, M., Pavcnik, D., Uchida, B., Loriaux, M., Kim, Y. H., Keller, F. & Rosch, J., Jun 2010, In : CardioVascular and Interventional Radiology. 33, 3, p. 596-600 5 p.

Research output: Contribution to journalArticle

Swine
Kidney
Foreign-Body Reaction
Urography
Infarction
1 Citation (Scopus)

Thrombus formation after percutaneous catheterization and manual compression of the femoral artery in heparinized sheep

Kim, Y. H., Pavcnik, D., Kakizawa, H., Uchida, B., Burke, A., Loriaux, M., Keller, F. & Rosch, J., Apr 2010, In : CardioVascular and Interventional Radiology. 33, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle

Femoral Artery
Hemostasis
Catheterization
Sheep
Angiography
2009
20 Citations (Scopus)

A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

Johnson, K. J., Griswold, I. J., O'Hare, T., Corbin, A. S., Loriaux, M., Deininger, M. W. & Druker, B., 2009, In : PLoS One. 4, 10, e0007439.

Research output: Contribution to journalArticle

leukemia
binding sites
Leukemia
Binding Sites
myeloid leukemia
691 Citations (Scopus)

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

O'Hare, T., Shakespeare, W. C., Zhu, X., Eide, C. A., Rivera, V. M., Wang, F., Adrian, L. T., Zhou, T., Huang, W. S., Xu, Q., Metcalf, C. A., Tyner, J., Loriaux, M., Corbin, A. S., Wardwell, S., Ning, Y., Keats, J. A., Wang, Y., Sundaramoorthi, R., Thomas, M. & 8 others, Zhou, D., Snodgrass, J., Commodore, L., Sawyer, T. K., Dalgarno, D. C., Deininger, M. W. N., Druker, B. & Clackson, T., Nov 6 2009, In : Cancer Cell. 16, 5, p. 401-412 12 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mutation
Phosphotransferases
Therapeutics
Mutagenesis
4 Citations (Scopus)

Functional characterization of an activating TEK mutation in acute myeloid leukemia: A cellular context-dependent activating mutation

Tyner, J., Rutenberg-Schoenberg, M. L., Erickson, H., Willis, S. G., O'Hare, T., Deininger, M. W., Druker, B. & Loriaux, M., 2009, In : Leukemia. 23, 7, p. 1345-1348 4 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Mutation
9 Citations (Scopus)

High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia

Tyner, J., Loriaux, M., Erickson, H., Eide, C. A., Deininger, J., MacPartlin, M., Willis, S. G., Lange, T., Druker, B., Kovacsovics, T., Maziarz, R., Gattermann, N. & Deininger, M. W., 2009, In : Leukemia. 23, 2, p. 406-409 4 p.

Research output: Contribution to journalArticle

DNA Mutational Analysis
Leukemia, Myelomonocytic, Chronic
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Proteomics
Protein-Tyrosine Kinases
86 Citations (Scopus)

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

Tyner, J., Erickson, H., Deininger, M. W. N., Willis, S. G., Eide, C. A., Levine, R. L., Heinrich, M., Gattermann, N., Gilliland, D. G., Druker, B. & Loriaux, M., Feb 19 2009, In : Blood. 113, 8, p. 1749-1755 7 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Exons
Assays
Screening
Throughput