Marc Loriaux

Associate Professor

  • 4852 Citations
  • 32 h-Index
1991 …2019
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  • 14 Similar Profiles
Acute Myeloid Leukemia Medicine & Life Sciences
Mutation Medicine & Life Sciences
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Medicine & Life Sciences
Protein-Tyrosine Kinases Medicine & Life Sciences
Leukemia Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
B-Cell Chronic Lymphocytic Leukemia Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences

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Projects 2011 2016

Phosphotransferases
Leukemia
Therapeutics
Protein-Tyrosine Kinases
Pharmaceutical Preparations

Research Output 1991 2019

  • 4852 Citations
  • 32 h-Index
  • 73 Article
  • 1 Letter
3 Citations (Scopus)

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E., Kaempf, A., Mori, M. T., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. & Tyner, J., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Acute Myeloid Leukemia
Macrophage Colony-Stimulating Factor
Cytokines
Cells
31 Citations (Scopus)

Functional genomic landscape of acute myeloid leukaemia

Tyner, J., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K-H., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M. T., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. & Druker, B., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
RNA Sequence Analysis
Pharmaceutical Preparations
Exome
Gene Regulatory Networks

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

Jenkins, C., Luty, S. B., Maxson, J., Eide, C. A., Abel, M. L., Togiai, C., Nemecek, E., Bottomly, D., McWeeney, S., Wilmot, B., Loriaux, M., Chang, B. & Tyner, J., Jul 17 2018, In : Science Signaling. 11, 539, eaao5617.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Leukemia
Acute Myeloid Leukemia
Myeloid Cells
Mitogen-Activated Protein Kinases
4 Citations (Scopus)

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A., Lee, P., Chantry, D., McWeeney, S., Druker, B., Tyner, J., Spurgeon, S. & Loriaux, M., May 15 2018, In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
B-Cell Chronic Lymphocytic Leukemia
Antineoplastic Agents
Monocytes
12 Citations (Scopus)

CPX-351 exhibits potent and direct ex vivo cytotoxicity against AML blasts with enhanced efficacy for cells harboring the FLT3-ITD mutation

Gordon, M. J., Tardi, P., Loriaux, M., Spurgeon, S., Traer, E., Kovacsovics, T., Mayer, L. D. & Tyner, J., Feb 1 2017, In : Leukemia Research. 53, p. 39-49 11 p.

Research output: Contribution to journalArticle

Mutation
B-Cell Chronic Lymphocytic Leukemia
Inhibitory Concentration 50
Daunorubicin
Myelodysplastic Syndromes