Marc Loriaux

Associate Professor

  • 5314 Citations
  • 33 h-Index
1991 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 5314 Citations
  • 33 h-Index
  • 65 Article
  • 6 Letter
  • 1 Comment/debate
  • 1 Review article
2019

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E. F., Kaempf, A., Mori, M., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. K. & Tyner, J. W., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

16 Scopus citations
2018

Functional genomic landscape of acute myeloid leukaemia

Tyner, J. W., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B. H., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K. H. T., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M. M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S. E., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. K. & Druker, B. J., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

108 Scopus citations

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

Jenkins, C., Luty, S. B., Maxson, J., Eide, C. A., Abel, M. L., Togiai, C., Nemecek, E., Bottomly, D., McWeeney, S., Wilmot, B., Loriaux, M., Chang, B. & Tyner, J., Jul 17 2018, In : Science Signaling. 11, 539, eaao5617.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A. V., Lee, P., Chantry, D., McWeeney, S. K., Druker, B. J., Tyner, J. W., Spurgeon, S. E. & Loriaux, M. M., May 15 2018, In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

CPX-351 exhibits potent and direct ex vivo cytotoxicity against AML blasts with enhanced efficacy for cells harboring the FLT3-ITD mutation

Gordon, M. J., Tardi, P., Loriaux, M., Spurgeon, S., Traer, E., Kovacsovics, T., Mayer, L. D. & Tyner, J., Feb 1 2017, In : Leukemia Research. 53, p. 39-49 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma

Scott, E., Maziarz, R., Spurgeon, S., Medvedova, E., Gajewski, J., Reasor-Heard, S., Park, B., Kratz, A., Thomas, G., Loriaux, M., Cascio, M., Podolak, J., Gordon, M., Botelho, J., Stadtmauer, E., Amaravadi, R. & Vogl, D. T., Jun 26 2017, In : Haematologica. 102, 7, p. e261-e265

Research output: Contribution to journalLetter

5 Scopus citations

SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia

Paiva, C., Rowland, T. A., Sreekantham, B., Godbersen, C., Best, S. R., Kaur, P., Loriaux, M., Spurgeon, S., Danilova, O. V. & Danilov, A., Oct 27 2017, In : Haematologica. 102, 11, p. 1890-1900 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016
27 Scopus citations

Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia

Leonard, J. T., Rowley, J. S. J., Eide, C. A., Traer, E., Hayes-Lattin, B., Loriaux, M., Spurgeon, S., Druker, B., Tyner, J. & Chang, B., Aug 31 2016, In : Science Translational Medicine. 8, 354, 354ra114.

Research output: Contribution to journalArticle

31 Scopus citations

The colony-Stimulating factor 3 receptor T640N mutation is oncogenic, sensitive toJAKInhibition, and mimics T618i

Maxson, J., Luty, S. B., MacManiman, J. D., Paik, J. C., Gotlib, J., Greenberg, P., Bahamadi, S., Savage, S. L., Abel, M. L., Eide, C. A., Loriaux, M., Stevens, E. A. & Tyner, J., Feb 1 2016, In : Clinical Cancer Research. 22, 3, p. 757-764 8 p.

Research output: Contribution to journalArticle

25 Scopus citations
2015

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Huan, J., Hornick, N. I., Goloviznina, N. A., Kamimae-Lanning, A. N., David, L., Wilmarth, P., Mori, M. T., Chevillet, J. R., Narla, A., Roberts, C., Loriaux, M., Chang, B. & Kurre, P., Jun 25 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

44 Scopus citations

Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression

Beer, P. A., Knapp, D. J. H. F., Miller, P. H., Kannan, N., Sloma, I., Heel, K., Babovic, S., Bulaeva, E., Rabu, G., Terry, J., Druker, B. J., Loriaux, M. M., Loeb, K. R., Radich, J. P., Erber, W. N. & Eaves, C. J., Jan 15 2015, In : Blood. 125, 3, p. 504-515 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
Open Access
31 Scopus citations

Therapeutically targetable ALK mutations in leukemia

Maxson, J. E., Davare, M. A., Luty, S. B., Eide, C. A., Chang, B. H., Loriaux, M. M., Tognon, C. E., Bottomly, D., Wilmot, B., McWeeney, S. K., Druker, B. J. & Tyner, J. W., Jun 1 2015, In : Cancer Research. 75, 11, p. 2146-2150 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

Chang, B. H., Johnson, K., LaTocha, D., Rowley, J. S. J., Bryant, J., Burke, R., Smith, R. L., Loriaux, M., Müschen, M., Mullighan, C., Druker, B. J. & Tyner, J. W., Apr 22 2015, In : Journal of Hematology and Oncology. 8, 1, 39.

Research output: Contribution to journalArticle

18 Scopus citations
2014

A potential therapeutic strategy for chronic lymphocytic leukemia by combining idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor

Burke, R. T., Meadows, S., Loriaux, M. M., Currie, K. S., Mitchell, S. A., Maciejewski, P., Clarke, A. S., Dipaolo, J. A., Druker, B. J., Lannutti, B. J. & Spurgeon, S. E., 2014, In : Oncotarget. 5, 4, p. 908-915 8 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

Agarwal, A., Mackenzie, R. J., Besson, A., Jeng, S., Carey, A., LaTocha, D. H., Fleischman, A. G., Duquesnes, N., Eide, C. A., Vasudevan, K. B., Loriaux, M. M., Firpo, E., Cortes, J. E., McWeeney, S., O'Hare, T., Roberts, J. M., Druker, B. J. & Deininger, M. W., Nov 20 2014, In : Blood. 124, 22, p. 3260-3273 14 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

A case study of personalized therapy for osteosarcoma

Davis, L. E., Hofmann, N. E., Li, G., Huang, E. T., Loriaux, M. M., Bracha, S., Helfand, S. C., Mata, J. E., Marley, K., Mansoor, A., Tyner, J. W., Abraham, J., Séguin, B. & Keller, C., Aug 1 2013, In : Pediatric Blood and Cancer. 60, 8, p. 1313-1319 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
4 Scopus citations

HitWalker: Variant prioritization for personalized functional cancer genomics

Bottomly, D., Wilmot, B., Tyner, J. W., Eide, C. A., Loriaux, M. M., Druker, B. J. & McWeeney, S. K., Feb 15 2013, In : Bioinformatics. 29, 4, p. 509-510 2 p.

Research output: Contribution to journalArticle

7 Scopus citations

Imatinib and dasatinib inhibit hemangiosarcoma and implicate PDGFR-β and Src in tumor growth

Dickerson, E. B., Marley, K., Edris, W., Tyner, J. W., Schalk, V., MacDonald, V., Loriaux, M., Druker, B. J. & Helfand, S. C., Apr 2013, In : Translational Oncology. 6, 2, p. 158-168 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening

Tyner, J. W., Yang, W. F., Bankhead, A., Fan, G., Fletcher, L. B., Bryant, J., Glover, J. M., Chang, B. H., Spurgeon, S. E., Fleming, W. H., Kovacsovics, T., Gotlib, J. R., Oh, S. T., Deininger, M. W., Zwaan, C. M., Den Boer, M. L., Van Den Heuvel-Eibrink, M. M., O'Hare, T., Druker, B. J. & Loriaux, M. M., Jan 1 2013, In : Cancer Research. 73, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

91 Scopus citations

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

Maxson, J. E., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., Bottomly, D., Wilmot, B., McWeeney, S. K., Tognon, C. E., Pond, J. B., Collins, R. H., Goueli, B., Stephen, T. O., Michael, W. D., Chang, B. H., Loriaux, M. M., Druker, B. J. & Tyner, J. W., Jan 1 2013, In : New England Journal of Medicine. 368, 19, p. 1781-1790 10 p.

Research output: Contribution to journalArticle

293 Scopus citations

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in Mice that is responsive to therapeutic JAK inhibition

Fleischman, A. G., Maxson, J. E., Luty, S. B., Agarwal, A., Royer, L. R., Abel, M. L., Macmaniman, J. D., Loriaux, M. M., Druker, B. J. & Tyner, J. W., Nov 21 2013, In : Blood. 122, 22, p. 3628-3631 4 p.

Research output: Contribution to journalArticle

62 Scopus citations

The selective syk inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemias

Spurgeon, S. E., Coffey, G., Fletcher, L. B., Burke, R., Tyner, J. W., Druker, B. J., Betz, A., DeGuzman, F., Pak, Y., Baker, D., Pandey, A., Hollenbach, S. J., Sinha, U. & Loriaux, M. M., Feb 1 2013, In : Journal of Pharmacology and Experimental Therapeutics. 344, 2, p. 378-387 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2012

An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma

Abraham, J., Chua, Y. X., Glover, J. M., Tyner, J. W., Loriaux, M. M., Kilcoyne, A., Giles, F. J., Nelon, L. D., Carew, J. S., Ouyang, Y., Michalek, J. E., Pal, R., Druker, B. J., Rubin, B. P. & Keller, C., Sep 28 2012, In : Biochemical and Biophysical Research Communications. 426, 3, p. 363-368 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Creation of fibrinogen-enhanced experimental blood clots to evaluate mechanical thrombectomy devices for treatment of acute stroke: An in vitro study

Luo, Z. H., Chung, A., Choi, G., Lin, Y. H., Uchida, B. T., Pavcnik, D., Loriaux, M. M., Nesbit, G. M., Keller, F. S. & Rösch, J., Aug 1 2012, In : Journal of Vascular and Interventional Radiology. 23, 8, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Bicocca, V. T., Chang, B. H., Masouleh, B. K., Muschen, M., Loriaux, M. M., Druker, B. J. & Tyner, J. W., Nov 13 2012, In : Cancer Cell. 22, 5, p. 656-667 12 p.

Research output: Contribution to journalArticle

97 Scopus citations

Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

Agarwal, A., Fleischman, A. G., Petersen, C. L., MacKenzie, R., Luty, S., Loriaux, M., Druker, B. J., Woltjer, R. L. & Deininger, M. W., Sep 27 2012, In : Blood. 120, 13, p. 2658-2668 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
15 Scopus citations

Multiplex high-throughput gene mutation analysis in acute myeloid leukemia

Dunlap, J., Beadling, C., Warrick, A., Neff, T., Fleming, W. H., Loriaux, M., Heinrich, M. C., Kovacsovics, T., Kelemen, K., Leeborg, N., Gatter, K., Braziel, R. M., Press, R., Corless, C. L. & Fan, G., Dec 1 2012, In : Human Pathology. 43, 12, p. 2167-2176 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia

Bains, T., Heinrich, M. C., Loriaux, M. M., Beadling, C., Nelson, D., Warrick, A., Neff, T. L., Tyner, J. W., Dunlap, J., Corless, C. L. & Fan, G., Sep 1 2012, In : Leukemia. 26, 9, p. 2144-2146 3 p.

Research output: Contribution to journalLetter

43 Scopus citations

TSLP signaling network revealed by SILAC-based phosphoproteomics

Zhong, J., Kim, M. S., Chaerkady, R., Wu, X., Huang, T. C., Getnet, D., Mitchell, C. J., Palapetta, S. M., Sharma, J., O'Meally, R. N., Cole, R. N., Yoda, A., Moritz, A., Loriaux, M. M., Rush, J., Weinstock, D. M., Tyner, J. W. & Pandey, A., Jun 1 2012, In : Molecular and Cellular Proteomics. 11, 6

Research output: Contribution to journalArticle

40 Scopus citations
2011
8 Scopus citations

CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Lannutti, B. J., Meadows, S. A., Herman, S. E. M., Kashishian, A., Steiner, B., Johnson, A. J., Byrd, J. C., Tyner, J. W., Loriaux, M. M., Deininger, M., Druker, B. J., Puri, K. D., Ulrich, R. G. & Giese, N. A., Jan 13 2011, In : Blood. 117, 2, p. 591-594 4 p.

Research output: Contribution to journalArticle

523 Scopus citations

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Corbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W. & Druker, B. J., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 396-409 14 p.

Research output: Contribution to journalArticle

499 Scopus citations

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies

Gozgit, J. M., Wong, M. J., Wardwell, S., Tyner, J. W., Loriaux, M. M., Mohemmad, Q. K., Narasimhan, N. I., Shakespeare, W. C., Wang, F., Druker, B. J., Clackson, T. & Rivera, V. M., Jun 1 2011, In : Molecular cancer therapeutics. 10, 6, p. 1028-1035 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Survey of activated FLT3 signaling in leukemia

Gu, T. L., Nardone, J., Wang, Y., Loriaux, M., Villén, J., Beausoleil, S., Tucker, M., Kornhauser, J., Ren, J., MacNeill, J., Gygi, S. P., Druker, B. J., Heinrich, M. C., Rush, J. & Polakiewicz, R. D., May 12 2011, In : PloS one. 6, 4, e19169.

Research output: Contribution to journalArticle

40 Scopus citations

TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

Fleischman, A. G., Aichberger, K. J., Luty, S. B., Bumm, T. G., Petersen, C. L., Doratotaj, S., Vasudevan, K. B., LaTocha, D. H., Yang, F., Press, R. D., Loriaux, M. M., Pahl, H. L., Silver, R. T., Agarwal, A., O'Hare, T., Druker, B. J., Bagby, G. C. & Deininger, M. W., Dec 8 2011, In : Blood. 118, 24, p. 6392-6398 7 p.

Research output: Contribution to journalArticle

126 Scopus citations
2010

A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib

McWeeney, S. K., Pemberton, L. C., Loriaux, M. M., Vartanian, K., Willis, S. G., Yochum, G., Wilmot, B., Turpaz, Y., Pillai, R., Druker, B. J., Snead, J. L., MacPartlin, M., O'Brien, S. G., Melo, J. V., Lange, T., Harrington, C. A. & Deininger, M. W. N., Jan 14 2010, In : Blood. 115, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

85 Scopus citations

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

Tyner, J. W., Bumm, T. G., Deininger, J., Wood, L., Aichberger, K. J., Loriaux, M. M., Druker, B. J., Burns, C. J., Fantino, E. & Deininger, M. W., Jun 24 2010, In : Blood. 115, 25, p. 5232-5240 9 p.

Research output: Contribution to journalArticle

158 Scopus citations

MET receptor sequence variants R970C and T992I lack transforming capacity

Tyner, J. W., Fletcher, L. B., Wang, E. Q., Yang, W. F., Rutenberg-Schoenberg, M. L., Beadling, C., Mori, M., Heinrich, M. C., Deininger, M. W., Druker, B. J. & Loriaux, M. M., Aug 1 2010, In : Cancer Research. 70, 15, p. 6233-6237 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Small intestinal submucosa plug for closure of dilated nephrostomy tracts: A pilot study in swine

Kakizawa, H., Conlin, M. J., Pavcnik, D., Uchida, B. T., Loriaux, M., Kim, Y. H., Keller, F. S. & Rösch, J., Jun 1 2010, In : Cardiovascular and interventional radiology. 33, 3, p. 596-600 5 p.

Research output: Contribution to journalArticle

Thrombus formation after percutaneous catheterization and manual compression of the femoral artery in heparinized sheep

Kim, Y. H., Pavcnik, D., Kakizawa, H., Uchida, B. T., Burke, A., Loriaux, M., Keller, F. S. & Rosch, J., Apr 1 2010, In : Cardiovascular and interventional radiology. 33, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2009

A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

Johnson, K. J., Griswold, I. J., O'Hare, T., Corbin, A. S., Loriaux, M., Deininger, M. W. & Druker, B. J., Dec 1 2009, In : PloS one. 4, 10, e0007439.

Research output: Contribution to journalArticle

21 Scopus citations

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

O'Hare, T., Shakespeare, W. C., Zhu, X., Eide, C. A., Rivera, V. M., Wang, F., Adrian, L. T., Zhou, T., Huang, W. S., Xu, Q., Metcalf, C. A., Tyner, J. W., Loriaux, M. M., Corbin, A. S., Wardwell, S., Ning, Y., Keats, J. A., Wang, Y., Sundaramoorthi, R., Thomas, M. & 8 others, Zhou, D., Snodgrass, J., Commodore, L., Sawyer, T. K., Dalgarno, D. C., Deininger, M. W. N., Druker, B. J. & Clackson, T., Nov 6 2009, In : Cancer Cell. 16, 5, p. 401-412 12 p.

Research output: Contribution to journalArticle

722 Scopus citations

Functional characterization of an activating TEK mutation in acute myeloid leukemia: A cellular context-dependent activating mutation

Tyner, J. W., Rutenberg-Schoenberg, M. L., Erickson, H., Willis, S. G., O'Hare, T., Deininger, M. W., Druker, B. J. & Loriaux, M. M., Jan 1 2009, In : Leukemia. 23, 7, p. 1345-1348 4 p.

Research output: Contribution to journalLetter

4 Scopus citations

High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia

Tyner, J. W., Loriaux, M. M., Erickson, H., Eide, C. A., Deininger, J., MacPartlin, M., Willis, S. G., Lange, T., Druker, B. J., Kovacsovics, T., Maziarz, R., Gattermann, N. & Deininger, M. W., Jan 1 2009, In : Leukemia. 23, 2, p. 406-409 4 p.

Research output: Contribution to journalLetter

9 Scopus citations