Jeffrey Tyner

Associate Professor

  • 5854 Citations
  • 37 h-Index
20022019
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Research Output 2002 2019

2017
26 Citations (Scopus)

Super-enhancers promote transcriptional dysregulation in nasopharyngeal carcinoma

Yuan, J., Jiang, Y. Y., Mayakonda, A., Huang, M., Ding, L. W., Lin, H., Yu, F., Lu, Y., Loh, T. K. S., Chow, M., Savage, S., Tyner, J., Lin, D. C. & Koeffler, H. P., Dec 1 2017, In : Cancer Research. 77, 23, p. 6614-6626 13 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Southeastern Asia
Nucleotide Motifs
Cyclin-Dependent Kinases
Gene Regulatory Networks
29 Citations (Scopus)

Turning the tide in myelodysplastic/myeloproliferative neoplasms

Deininger, M. W. N., Tyner, J. & Solary, E., Jul 1 2017, In : Nature Reviews Cancer. 17, 7, p. 425-440 16 p.

Research output: Contribution to journalReview article

Myelodysplastic Syndromes
Epigenomics
Genotype
Physiological Phenomena
Phenotype
17 Citations (Scopus)

UNC2025, a MERTK small-molecule inhibitor, is therapeutically effective alone and in combination with methotrexate in leukemia models

DeRyckere, D., Lee-Sherick, A. B., Huey, M. G., Hill, A. A., Tyner, J., Jacobsen, K. M., Page, L. S., Kirkpatrick, G. G., Eryildiz, F., Montgomery, S. A., Zhang, W., Wang, X., Frye, S. V., Earp, H. S. & Graham, D. K., Mar 15 2017, In : Clinical Cancer Research. 23, 6, p. 1481-1492 12 p.

Research output: Contribution to journalArticle

Methotrexate
Leukemia
Acute Myeloid Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Heterografts
6 Citations (Scopus)

Unpaired extracellular cysteine mutations of CSF3R mediate gain or loss of function

Zhang, H., Means, S., Schultz, A. R., Watanabe-Smith, K., Medeiros, B. C., Bottomly, D., Wilmot, B., McWeeney, S., Kükenshöner, T., Hantschel, O. & Tyner, J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4258-4267 10 p.

Research output: Contribution to journalArticle

Cysteine
Mutation
Leukemia, Neutrophilic, Chronic
Leukemia
Granulocyte Colony-Stimulating Factor Receptors
2016
23 Citations (Scopus)
Neoplasm Drug Resistance
Exosomes
Protein Kinase Inhibitors
MicroRNAs
Mesenchymal Stromal Cells
6 Citations (Scopus)

Clonality of neutrophilia associated with plasma cell neoplasms: Report of a SETBP1 mutation and analysis of a single institution series

Stevens, B., Maxson, J., Tyner, J., Smith, C. A., Gutman, J. A., Robinson, W., Jordan, C. T., Lee, C. K., Swisshelm, K., Tobin, J., Wei, Q., Schowinsky, J., Rinella, S., Lee, H. G. & Pollyea, D. A., Apr 2 2016, In : Leukemia and Lymphoma. 57, 4, p. 927-934 8 p.

Research output: Contribution to journalArticle

Plasma Cell Neoplasms
Mutation
Preclinical Drug Evaluations
Granulocyte Colony-Stimulating Factor
Cytogenetics
10 Citations (Scopus)

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Richard, N. P., Pippa, R., Cleary, M. M., Puri, A., Tibbitts, D., Mahmood, S., Christensen, D. J., Jeng, S., McWeeney, S., Look, A. T., Chang, B., Tyner, J., Vitek, M. P., Odero, M. D., Sears, R. & Agarwal, A., 2016, In : Oncotarget. 7, 51, p. 84214-84227 14 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Protein Phosphatase 2
Cell Line
Phosphotransferases
6 Citations (Scopus)

Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia

Watanabe-Smith, K., Tognon, C., Tyner, J., Meijerink, J. P. P., Druker, B. & Agarwal, A., Sep 1 2016, In : Leukemia. 30, 9, p. 1950-1953 4 p.

Research output: Contribution to journalLetter

27 Citations (Scopus)

FGF2 from marrow microenvironment promotes resistance to FLT3 inhibitors in acute myeloid leukemia

Traer, E., Martinez, J., Javidi-Sharifi, N., Agarwal, A., Dunlap, J., English, I., Kovacsovics, T., Tyner, J., Wong, M. & Druker, B., Nov 15 2016, In : Cancer Research. 76, 22, p. 6471-6482 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Acute Myeloid Leukemia
Bone Marrow
Ligands
Mutation
7 Citations (Scopus)
Germ Cell and Embryonal Neoplasms
Mitogen-Activated Protein Kinase Kinases
Genetic Testing
Acute Myeloid Leukemia
Mutation
15 Citations (Scopus)

Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis

Maxson, J., Abel, M. L., Wang, J., Deng, X., Reckel, S., Luty, S. B., Sun, H., Gorenstein, J., Hughes, S. B., Bottomly, D., Wilmot, B., McWeeney, S., Radich, J., Hantschel, O., Middleton, R. E., Gray, N. S., Druker, B. & Tyner, J., Jan 1 2016, In : Cancer Research. 76, 1, p. 127-138 12 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Leukemia
Phosphotransferases
Mutation
Leukemia, Myelomonocytic, Chronic

JAKed up phenotype of CEBPA-mutant AML

Tyner, J., Jun 16 2016, In : Blood. 127, 24, p. 2946-2947 2 p.

Research output: Contribution to journalReview article

Data integration
Genetic Association Studies
Acute Myeloid Leukemia
Blood
Phenotype
18 Citations (Scopus)

Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism

Garbati, M. R., Welgan, C. A., Landefeld, S. H., Newell, L., Agarwal, A., Dunlap, J., Chourasia, T. K., Lee, H., Elferich, J., Traer, E., Rattray, R., Cascio, M., Press, R., Bagby, G. C., Tyner, J., Druker, B. & Dao, K-H., Feb 1 2016, In : American Journal of Hematology. 91, 2, p. 211-219 9 p.

Research output: Contribution to journalArticle

Calreticulin
Monocytes
Thrombocytosis
Primary Myelofibrosis
Genes
1 Citation (Scopus)

RNAi screening of leukemia cells using electroporation

Agarwal, A. & Tyner, J., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1470. p. 85-94 10 p. (Methods in Molecular Biology; vol. 1470).

Research output: Chapter in Book/Report/Conference proceedingChapter

Electroporation
RNA Interference
Transfection
Leukemia
Cell Line
27 Citations (Scopus)

Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia

Leonard, J. T., Rowley, J. S. J., Eide, C. A., Traer, E., Hayes-Lattin, B., Loriaux, M., Spurgeon, S., Druker, B., Tyner, J. & Chang, B., Aug 31 2016, In : Science Translational Medicine. 8, 354, 354ra114.

Research output: Contribution to journalArticle

Philadelphia Chromosome
B-Cell Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Therapeutics
51 Citations (Scopus)

Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma

Jiang, Y. Y., Lin, D. C., Mayakonda, A., Hazawa, M., Ding, L. W., Chien, W. W., Xu, L., Chen, Y., Xiao, J. F., Senapedis, W., Baloglu, E., Kanojia, D., Shang, L., Xu, X., Yang, H., Tyner, J., Wang, M. R. & Koeffler, H. P., May 10 2016, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Oncogenes
RNA Sequence Analysis
Esophageal Squamous Cell Carcinoma
Investigational Therapies
Chromatin Immunoprecipitation
24 Citations (Scopus)

The colony-Stimulating factor 3 receptor T640N mutation is oncogenic, sensitive toJAKInhibition, and mimics T618i

Maxson, J., Luty, S. B., MacManiman, J. D., Paik, J. C., Gotlib, J., Greenberg, P., Bahamadi, S., Savage, S. L., Abel, M. L., Eide, C. A., Loriaux, M., Stevens, E. A. & Tyner, J., Feb 1 2016, In : Clinical Cancer Research. 22, 3, p. 757-764 8 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Leukemia, Neutrophilic, Chronic
Mutation
Janus Kinases
3 Citations (Scopus)

Ultrasensitive proteomic quantitation of cellular signaling by digitized nanoparticle-protein counting

Jacob, T., Agarwal, A., Ramunno-Johnson, D., O'Hare, T., Gonen, M., Tyner, J., Druker, B. & Vu, T. T., Jun 20 2016, In : Scientific Reports. 6, 28163.

Research output: Contribution to journalArticle

Proteomics
Nanoparticles
Quantum Dots
Proteins
Pharmaceutical Preparations
2015
30 Citations (Scopus)

Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer

Chien, W., Sun, Q. Y., Lee, K. L., Ding, L. W., Wuensche, P., Torres-Fernandez, L. A., Tan, S. Z., Tokatly, I., Zaiden, N., Poellinger, L., Mori, S., Yang, H., Tyner, J. & Koeffler, H. P., Apr 1 2015, In : Molecular Oncology. 9, 4, p. 889-905 17 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Pancreatic Neoplasms
Penfluridol
Neoplasms
Thioridazine
49 Citations (Scopus)

Age-related mutations and chronic myelomonocytic leukemia

Mason, C. C., Khorashad, J. S., Tantravahi, S. K., Kelley, T. W., Zabriskie, M. S., Yan, D., Pomicter, A. D., Reynolds, K. R., Eiring, A. M., Kronenberg, Z., Sherman, R. L., Tyner, J., Dalley, B. K., Dao, K-H., Yandell, M., Druker, B., Gotlib, J., O'Hare, T. & Deininger, M. W., Dec 9 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Mutation
Hematopoiesis
Genes
Exome
39 Citations (Scopus)

Crosstalk between KIT and FGFR3 promotes gastrointestinal stromal tumor cell growth and drug resistance

Javidi-Sharifi, N., Traer, E., Martinez, J., Gupta, A., Taguchi, T., Dunlap, J., Heinrich, M., Corless, C., Rubin, B. P., Druker, B. & Tyner, J., Mar 1 2015, In : Cancer Research. 75, 5, p. 880-891 12 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Stromal Cells
Drug Resistance
Growth
Fibroblast Growth Factor 2
4 Citations (Scopus)

Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia

Agarwal, A., Mackenzie, R. J., Eide, C. A., Davare, M., Watanabe-Smith, K., Tognon, C. E., Mongoue-Tchokote, S., Park, B., Braziel, R., Tyner, J. & Druker, B., Jun 4 2015, In : Oncogene. 34, 23, p. 2991-2999 9 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Interleukin-2 Receptors
RNA Interference
Leukemia
Cytokines
37 Citations (Scopus)

Genomic landscape of liposarcoma

Kanojia, D., Nagata, Y., Garg, M., Lee, D. H., Sato, A., Yoshida, K., Sato, Y., Sanada, M., Mayakonda, A., Bartenhagen, C., Klein, H. U., Doan, N. B., Said, J. W., Mohith, S., Gunasekar, S., Shiraishi, Y., Chiba, K., Tanaka, H., Miyano, S., Myklebost, O. & 8 others, Yang, H., Dugas, M., Meza-Zepeda, L. A., Silberman, A. W., Forscher, C., Tyner, J., Ogawa, S. & Phillip Koeffler, H., 2015, In : Oncotarget. 6, 40, p. 42429-42444 16 p.

Research output: Contribution to journalArticle

Liposarcoma
Neurofibromin 1
Exome
Chromosomes
Sarcoma

Integrated analysis of CRLF2 signaling in acute lymphoblastic leukemia identifies Polo-like kinase 1 as a potential therapeutic target

Huang, T. C., Cutler, J., Bharne, S., Zhong, J., Weinstock, D., Tyner, J., Gojo, I., Civin, C. & Pandey, A., May 1 2015, In : Leukemia and Lymphoma. 56, 5, p. 1524-1527 4 p.

Research output: Contribution to journalArticle

Xenograft Model Antitumor Assays
Proto-Oncogene Proteins
Molecular Targeted Therapy
Animal Disease Models
Cell Cycle Proteins
31 Citations (Scopus)

Mutations in G protein β subunits promote transformation and kinase inhibitor resistance

Yoda, A., Adelmant, G., Tamburini, J., Chapuy, B., Shindoh, N., Yoda, Y., Weigert, O., Kopp, N., Wu, S. C., Kim, S. S., Liu, H., Tivey, T., Christie, A. L., Elpek, K. G., Card, J., Gritsman, K., Gotlib, J., Deininger, M. W., Makishima, H., Turley, S. J. & 9 others, Javidi-Sharifi, N., Maciejewski, J. P., Jaiswal, S., Ebert, B. L., Rodig, S. J., Tyner, J., Marto, J. A., Weinstock, D. M. & Lane, A. A., Jan 1 2015, In : Nature Medicine. 21, 1, p. 71-75 5 p.

Research output: Contribution to journalArticle

Protein Subunits
GTP-Binding Proteins
Phosphotransferases
Mutation
Gene encoding
55 Citations (Scopus)

Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia

Geng, H., Hurtz, C., Lenz, K. B., Chen, Z., Baumjohann, D., Thompson, S., Goloviznina, N. A., Chen, W. Y., Huan, J., LaTocha, D., Ballabio, E., Xiao, G., Lee, J. W., Deucher, A., Qi, Z., Park, E., Huang, C., Nahar, R., Kweon, S. M., Shojaee, S. & 18 others, Chan, L. N., Yu, J., Kornblau, S. M., Bijl, J. J., Ye, B. H., Mark Ansel, K., Paietta, E., Melnick, A., Hunger, S. P., Kurre, P., Tyner, J., Loh, M. L., Roeder, R. G., Druker, B., Burger, J. A., Milne, T. A., Chang, B. & Müschen, M., Mar 9 2015, In : Cancer Cell. 27, 3, p. 409-425 17 p.

Research output: Contribution to journalArticle

Pre-B Cell Receptors
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Clinical Trials
48 Citations (Scopus)
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Colony-Stimulating Factor Receptors
Leukemia, Neutrophilic, Chronic
Clinical Trials
Mutation
30 Citations (Scopus)
Melphalan
Pharmaceutical Preparations
Multiple Myeloma
Cell Line
Bortezomib
13 Citations (Scopus)

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

Lue, H. W., Cole, B., Rao, S. A. M., Podolak, J., Van Gaest, A., King, C., Eide, C. A., Wilmot, B., Xue, C., Spellman, P., Heiser, L., Tyner, J. & Thomas, G., 2015, In : Oncotarget. 6, 42, p. 44675-44687 13 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Cell Survival
Cell Proliferation
Organ Size
51 Citations (Scopus)

The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development

Kang, X., Lu, Z., Cui, C., Deng, M., Fan, Y., Dong, B., Han, X., Xie, F., Tyner, J., Coligan, J. E., Collins, R. H., Xiao, X., You, M. J. & Zhang, C. C., May 5 2015, In : Nature Cell Biology. 17, 5, p. 665-677 13 p.

Research output: Contribution to journalArticle

Immunoreceptor Tyrosine-Based Inhibition Motif
Acute Myeloid Leukemia
Leukemia
Myeloid Progenitor Cells
Hematopoiesis
8 Citations (Scopus)

Therapeutically targetable ALK mutations in leukemia

Maxson, J., Davare, M., Luty, S. B., Eide, C. A., Chang, B., Loriaux, M., Tognon, C. E., Bottomly, D., Wilmot, B., McWeeney, S., Druker, B. & Tyner, J., Jun 1 2015, In : Cancer Research. 75, 11, p. 2146-2150 5 p.

Research output: Contribution to journalArticle

Leukemia
Mutation
Phosphotransferases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Point Mutation
18 Citations (Scopus)

What's different about atypical CML and chronic neutrophilic leukemia?

Dao, K-H. & Tyner, J., Dec 5 2015, In : Hematology. 2015, 1, p. 264-271 8 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Leukemia, Neutrophilic, Chronic
Mutation
Inborn Genetic Diseases
Mutation Rate
14 Citations (Scopus)

YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

Chang, B., Johnson, K., LaTocha, D., Rowley, J. S. J., Bryant, J., Burke, R., Smith, R. L., Loriaux, M., Müschen, M., Mullighan, C., Druker, B. & Tyner, J., Apr 22 2015, In : Journal of Hematology and Oncology. 8, 1, 39.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA Damage
S Phase
Phosphorylation
Cell Line
2014
74 Citations (Scopus)

Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia

Agarwal, A., MacKenzie, R. J., Pippa, R., Eide, C. A., Oddo, J., Tyner, J., Sears, R., Vitek, M. P., Odero, M. D., Christensen, D. J. & Druker, B., Apr 15 2014, In : Clinical Cancer Research. 20, 8, p. 2092-2103 12 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Drug Resistance
Protein-Tyrosine Kinases
15 Citations (Scopus)

Corepressor Rcor1 is essential for murine erythropoiesis

Yao, H., Goldman, D., Nechiporuk, T., Kawane, S., McWeeney, S., Tyner, J., Fan, G., Kerenyi, M. A., Orkin, S. H., Fleming, W. & Mandel, G., May 15 2014, In : Blood. 123, 20, p. 3175-3184 10 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Erythropoiesis
Genes
Erythroblasts
Colony-Stimulating Factor Receptors
9 Citations (Scopus)

Functional genomics for personalized cancer therapy

Tyner, J., Jul 2 2014, In : Science Translational Medicine. 6, 243, 243fs26.

Research output: Contribution to journalArticle

Genomics
Neoplasms
Therapeutics
36 Citations (Scopus)

Functional integration of acute myeloid leukemia into the vascular niche

Cogle, C. R., Goldman, D., Madlambayan, G. J., Leon, R. P., Al Masri, A., Clark, H. A., Asbaghi, S. A., Tyner, J., Dunlap, J., Fan, G., Kovacsovics, T., Liu, Q., Meacham, A., Hamlin, K. L., Hromas, R. A., Scott, E. W. & Fleming, W., Oct 1 2014, In : Leukemia. 28, 10, p. 1978-1987 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Blood Vessels
Endothelial Cells
Myeloid Cells
Vascular Endothelium
37 Citations (Scopus)

Heterogeneity of pancreatic cancer metastases in a single patient revealed by quantitative proteomics

Kim, M. S., Zhong, Y., Yachida, S., Rajeshkumar, N. V., Abel, M. L., Marimuthu, A., Mudgal, K., Hruban, R. H., Poling, J. S., Tyner, J., Maitra, A., Iacobuzio-Donahue, C. A. & Pandey, A., Nov 1 2014, In : Molecular and Cellular Proteomics. 13, 11, p. 2803-2811 9 p.

Research output: Contribution to journalArticle

Proteome
Pancreatic Neoplasms
Liver
Proteomics
Tumors
26 Citations (Scopus)
Colony-Stimulating Factor Receptors
Glycosylation
Colony-Stimulating Factors
Dimerization
Ligands
15 Citations (Scopus)

PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma

Aslam, M. I., Abraham, J., Mansoor, A., Druker, B., Tyner, J. & Keller, C., Apr 29 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 17, p. 6383-6388 6 p.

Research output: Contribution to journalArticle

Alveolar Rhabdomyosarcoma
Eph Family Receptors
Ligands
Neoplasms
Cell Survival
32 Citations (Scopus)

Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations

Traer, E., Javidi-Sharifi, N., Agarwal, A., Dunlap, J., English, I., Martinez, J., Tyner, J., Wong, M. & Druker, B., Mar 6 2014, In : Blood. 123, 10, p. 1516-1524 9 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Phosphotransferases
Fibroblast Growth Factor Receptors
Mutation
32 Citations (Scopus)

TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling.

Zhong, J., Sharma, J., Raju, R., Palapetta, S. M., Prasad, T. S. K., Huang, T. C., Yoda, A., Tyner, J., van Bodegom, D., Weinstock, D. M., Ziegler, S. F. & Pandey, A., 2014, In : Database : the journal of biological databases and curation. 2014

Research output: Contribution to journalArticle

receptors
cytokines
T-lymphocytes
interleukin-7
Regulatory T-Lymphocytes
2013
14 Citations (Scopus)

A case study of personalized therapy for osteosarcoma

Davis, L., Hofmann, N. E., Li, G., Huang, E. T., Loriaux, M., Bracha, S., Helfand, S. C., Mata, J. E., Marley, K., Mansoor, A., Tyner, J., Abraham, J., Séguin, B. & Keller, C., Aug 2013, In : Pediatric Blood and Cancer. 60, 8, p. 1313-1319 7 p.

Research output: Contribution to journalArticle

Osteosarcoma
Sarcoma
Canidae
Neoplasms
Therapeutics
1 Citation (Scopus)
Renal Cell Carcinoma
Protein-Tyrosine Kinases
Cultured Tumor Cells
Neoplasms
Vascular Endothelial Growth Factor Receptor
24 Citations (Scopus)

Belinostat and panobinostat (HDACI): In vitro and in vivo studies in thyroid cancer

Chan, D., Zheng, Y., Tyner, J., Chng, W. J., Chien, W. W., Gery, S., Leong, G., Braunstein, G. D. & Koeffler, H. P., Sep 2013, In : Journal of Cancer Research and Clinical Oncology. 139, 9, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Thyroid Neoplasms
Protein-Tyrosine Kinases
Apoptosis
Cell Line
6 Citations (Scopus)

Causal role for JAK2 V617F in thrombosis

Fleischman, A. G. & Tyner, J., Nov 28 2013, In : Blood. 122, 23, p. 3705-3706 2 p.

Research output: Contribution to journalArticle

Thrombosis
Blood
Alleles
Monitoring
Clinical Trials
4 Citations (Scopus)
Precision Medicine
Genes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Small Interfering RNA
Genome
131 Citations (Scopus)

CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia

Pardanani, A., Lasho, T. L., Laborde, R. R., Elliott, M., Hanson, C. A., Knudson, R. A., Ketterling, R. P., Maxson, J., Tyner, J. & Tefferi, A., Sep 2013, In : Leukemia. 27, 9, p. 1870-1873 4 p.

Research output: Contribution to journalArticle

Leukemia, Neutrophilic, Chronic
Mutation
Exons
Paraproteinemias
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
33 Citations (Scopus)
Drug Synergism
Naphthyridines
Quinazolinones
Pyrazoles
Vidarabine
16 Citations (Scopus)

Dynamic and nuclear expression of PDGFRα and IGF-1R in alveolar rhabdomyosarcoma

Aslam, M. I., Hettmer, S., Abraham, J., Latocha, D., Soundararajan, A., Huang, E. T., Goros, M. W., Michalek, J. E., Wang, S., Mansoor, A., Druker, B., Wagers, A. J., Tyner, J. & Keller, C., Nov 2013, In : Molecular Cancer Research. 11, 11, p. 1303-1313 11 p.

Research output: Contribution to journalArticle

Alveolar Rhabdomyosarcoma
Platelet-Derived Growth Factor
Somatomedins
Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases