Jeffrey Tyner

Associate Professor

  • 5854 Citations
  • 37 h-Index
20022019
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Research Output 2002 2019

14 Citations (Scopus)

A case study of personalized therapy for osteosarcoma

Davis, L., Hofmann, N. E., Li, G., Huang, E. T., Loriaux, M., Bracha, S., Helfand, S. C., Mata, J. E., Marley, K., Mansoor, A., Tyner, J., Abraham, J., Séguin, B. & Keller, C., Aug 2013, In : Pediatric Blood and Cancer. 60, 8, p. 1313-1319 7 p.

Research output: Contribution to journalArticle

Osteosarcoma
Sarcoma
Canidae
Neoplasms
Therapeutics
243 Citations (Scopus)

Activating alleles of JAK3 in acute megakaryoblastic leukemia

Walters, D. K., Mercher, T., Gu, T. L., O'Hare, T., Tyner, J., Loriaux, M., Goss, V. L., Lee, K. A., Eide, C. A., Wong, M. J., Stoffregen, E. P., McGreevey, L., Nardone, J., Moore, S. A., Crispino, J., Boggon, T. J., Heinrich, M., Deininger, M. W., Polakiewicz, R. D., Gilliland, D. G. & 1 others, Druker, B., Jul 2006, In : Cancer Cell. 10, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

Leukemia, Megakaryoblastic, Acute
Alleles
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Mutation
30 Citations (Scopus)

Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer

Chien, W., Sun, Q. Y., Lee, K. L., Ding, L. W., Wuensche, P., Torres-Fernandez, L. A., Tan, S. Z., Tokatly, I., Zaiden, N., Poellinger, L., Mori, S., Yang, H., Tyner, J. & Koeffler, H. P., Apr 1 2015, In : Molecular Oncology. 9, 4, p. 889-905 17 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Pancreatic Neoplasms
Penfluridol
Neoplasms
Thioridazine
31 Citations (Scopus)

Acute and chronic airway responses to viral infection: Implications for asthma and chronic obstructive pulmonary disease

Holtzman, M. J., Tyner, J., Kim, E. Y., Lo, M. S., Patel, A. C., Shornick, L. P., Agapov, E. & Zhang, Y., 2005, In : Proceedings of the American Thoracic Society. 2, 2, p. 132-140 9 p.

Research output: Contribution to journalArticle

Virus Diseases
Chronic Obstructive Pulmonary Disease
Antiviral Agents
Asthma
Viral Bronchiolitis
49 Citations (Scopus)

Age-related mutations and chronic myelomonocytic leukemia

Mason, C. C., Khorashad, J. S., Tantravahi, S. K., Kelley, T. W., Zabriskie, M. S., Yan, D., Pomicter, A. D., Reynolds, K. R., Eiring, A. M., Kronenberg, Z., Sherman, R. L., Tyner, J., Dalley, B. K., Dao, K-H., Yandell, M., Druker, B., Gotlib, J., O'Hare, T. & Deininger, M. W., Dec 9 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Mutation
Hematopoiesis
Genes
Exome
23 Citations (Scopus)
Neoplasm Drug Resistance
Exosomes
Protein Kinase Inhibitors
MicroRNAs
Mesenchymal Stromal Cells
1 Citation (Scopus)
Renal Cell Carcinoma
Protein-Tyrosine Kinases
Cultured Tumor Cells
Neoplasms
Vascular Endothelial Growth Factor Receptor
11 Citations (Scopus)

An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma

Abraham, J., Chua, Y. X., Glover, J. M., Tyner, J., Loriaux, M., Kilcoyne, A., Giles, F. J., Nelon, L. D., Carew, J. S., Ouyang, Y., Michalek, J. E., Pal, R., Druker, B., Rubin, B. P. & Keller, C., Sep 28 2012, In : Biochemical and Biophysical Research Communications. 426, 3, p. 363-368 6 p.

Research output: Contribution to journalArticle

Alveolar Rhabdomyosarcoma
Rhabdomyosarcoma
Tumors
Cell culture
Primary Cell Culture
3 Citations (Scopus)

A novel AGGF1-PDGFRβ fusion in pediatric T-cell acute lymphoblastic leukemia

Zabriskie, M. S., Antelope, O., Verma, A. R., Draper, L. R., Eide, C. A., Pomicter, A. D., Tran, T. H., Druker, B., Tyner, J., Miles, R. R., Graham, J. M., Hwang, J. Y., Varley, K. E., Toydemir, R. M., Deininger, M. W., Raetz, E. A. & O’Hare, T., Jan 31 2018, In : Haematologica. 103, 2, p. e87-e91

Research output: Contribution to journalComment/debate

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics
30 Citations (Scopus)

A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia

Gu, T. L., Mercher, T., Tyner, J., Goss, V. L., Walters, D. K., Cornejo, M. G., Reeves, C., Popova, L., Lee, K., Heinrich, M., Rush, J., Daibata, M., Miyoshi, I., Gilliland, D. G., Druker, B. & Polakiewicz, R. D., Jul 1 2007, In : Blood. 110, 1, p. 323-333 11 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Leukemia, Megakaryoblastic, Acute
Macrophage Colony-Stimulating Factor
Fusion reactions
RNA
74 Citations (Scopus)

Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia

Agarwal, A., MacKenzie, R. J., Pippa, R., Eide, C. A., Oddo, J., Tyner, J., Sears, R., Vitek, M. P., Odero, M. D., Christensen, D. J. & Druker, B., Apr 15 2014, In : Clinical Cancer Research. 20, 8, p. 2092-2103 12 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Drug Resistance
Protein-Tyrosine Kinases
702 Citations (Scopus)

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

O'Hare, T., Shakespeare, W. C., Zhu, X., Eide, C. A., Rivera, V. M., Wang, F., Adrian, L. T., Zhou, T., Huang, W. S., Xu, Q., Metcalf, C. A., Tyner, J., Loriaux, M., Corbin, A. S., Wardwell, S., Ning, Y., Keats, J. A., Wang, Y., Sundaramoorthi, R., Thomas, M. & 8 others, Zhou, D., Snodgrass, J., Commodore, L., Sawyer, T. K., Dalgarno, D. C., Deininger, M. W. N., Druker, B. & Clackson, T., Nov 6 2009, In : Cancer Cell. 16, 5, p. 401-412 12 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mutation
Phosphotransferases
Therapeutics
Mutagenesis
24 Citations (Scopus)

Apoptosis in the airways: Another balancing act in the epithelial program

O'Sullivan, M. P., Tyner, J. & Holtzman, M. J., Jul 1 2003, In : American Journal of Respiratory Cell and Molecular Biology. 29, 1, p. 3-7 5 p.

Research output: Contribution to journalArticle

Respiratory system
Signal transduction
Pulmonary diseases
Apoptosis
Epithelial Cells
5 Citations (Scopus)

ARID1A and CEBPα cooperatively inhibit UCA1 transcription in breast cancer

Guo, X., Zhang, Y., Mayakonda, A., Madan, V., Ding, L. W., Lin, L. H., Zia, S., Gery, S., Tyner, J., Zhou, W., Yin, D., Lin, D. C. & Koeffler, H. P., Jul 6 2018, (Accepted/In press) In : Oncogene. p. 1-13 13 p.

Research output: Contribution to journalArticle

Histone Code
Cell Proliferation
Long Noncoding RNA
Breast Neoplasms
Mutation

Automated decision tree to evaluate genetic abnormalities when determining prognostic risk in acute myeloid leukemia

Watanabe-Smith, K., Druker, B., Tyner, J. & Edwards, D. K., Jul 31 2018, In : Haematologica. 103, 8, p. e351-e355

Research output: Contribution to journalLetter

Decision Trees
Acute Myeloid Leukemia
18 Citations (Scopus)

BCL6 promotes glioma and serves as a therapeutic target

Xu, L., Chen, Y., Dutra-Clarke, M., Mayakonda, A., Hazawa, M., Savinoff, S. E., Doan, N., Said, J. W., Yong, W. H., Watkins, A., Yang, H., Ding, L. W., Jiang, Y. Y., Tyner, J., Ching, J., Kovalik, J. P., Madan, V., Chan, S. L., Müschen, M., Breunig, J. J. & 3 others, Lin, D. C., Koeffler, H. P. & Cavenee, W. K., 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 15

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Ribosomal Protein S6
Ribosomal Protein S6 Kinases
Mitogen-Activated Protein Kinase Kinases
24 Citations (Scopus)

Belinostat and panobinostat (HDACI): In vitro and in vivo studies in thyroid cancer

Chan, D., Zheng, Y., Tyner, J., Chng, W. J., Chien, W. W., Gery, S., Leong, G., Braunstein, G. D. & Koeffler, H. P., Sep 2013, In : Journal of Cancer Research and Clinical Oncology. 139, 9, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Thyroid Neoplasms
Protein-Tyrosine Kinases
Apoptosis
Cell Line
176 Citations (Scopus)

Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals

Tyner, J., Kim, E. Y., Ide, K., Pelletier, M. R., Roswit, W. T., Morton, J. D., Battaile, J. T., Patel, A. C., Patterson, G. A., Castro, M., Spoor, M. S., You, Y., Brody, S. L. & Holtzman, M. J., Feb 1 2006, In : Journal of Clinical Investigation. 116, 2, p. 309-321 13 p.

Research output: Contribution to journalArticle

Goblet Cells
Interleukin-13
Metaplasia
Hyperplasia
Genetic Predisposition to Disease
509 Citations (Scopus)

CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Lannutti, B. J., Meadows, S. A., Herman, S. E. M., Kashishian, A., Steiner, B., Johnson, A. J., Byrd, J. C., Tyner, J., Loriaux, M., Deininger, M., Druker, B., Puri, K. D., Ulrich, R. G. & Giese, N. A., Jan 13 2011, In : Blood. 117, 2, p. 591-594 4 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Phosphatidylinositol 3-Kinases
B-Lymphocytes
Cells
Neoplasms
6 Citations (Scopus)

Causal role for JAK2 V617F in thrombosis

Fleischman, A. G. & Tyner, J., Nov 28 2013, In : Blood. 122, 23, p. 3705-3706 2 p.

Research output: Contribution to journalArticle

Thrombosis
Blood
Alleles
Monitoring
Clinical Trials
189 Citations (Scopus)

CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection

Tyner, J., Uchida, O., Kajiwara, N., Kim, E. Y., Patel, A. C., O'Sullivan, M. P., Walter, M. J., Schwendener, R. A., Cook, D. N., Danoff, T. M. & Holtzman, M. J., Nov 2005, In : Nature Medicine. 11, 11, p. 1180-1187 8 p.

Research output: Contribution to journalArticle

Macrophages
Virus Diseases
Viruses
Chemokines
Paramyxoviridae Infections
9 Citations (Scopus)

Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations

Zhang, H., Reister Schultz, A., Luty, S., Rofelty, A., Su, Y., Means, S., Bottomly, D., Wilmot, B., McWeeney, S. & Tyner, J., Dec 1 2017, In : Leukemia. 31, 12, p. 2752-2760 9 p.

Research output: Contribution to journalArticle

Missense Mutation
Mutation
High-Throughput Nucleotide Sequencing
Ubiquitination
Leukemia
9 Citations (Scopus)

Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia

Bandyopadhyay, S., Li, J., Traer, E., Tyner, J., Zhou, A., Oh, S. T. & Cheng, J. X., Jul 1 2017, In : PLoS One. 12, 7, e0179558.

Research output: Contribution to journalArticle

Esterification
esterification
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
leukemia
Cholesterol
12 Citations (Scopus)

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. & Tyner, J., Dec 1 2019, In : Nature Communications. 10, 1, 244.

Research output: Contribution to journalArticle

leukemias
mutations
Acute Myeloid Leukemia
Mutation
inhibitors
6 Citations (Scopus)

Clonality of neutrophilia associated with plasma cell neoplasms: Report of a SETBP1 mutation and analysis of a single institution series

Stevens, B., Maxson, J., Tyner, J., Smith, C. A., Gutman, J. A., Robinson, W., Jordan, C. T., Lee, C. K., Swisshelm, K., Tobin, J., Wei, Q., Schowinsky, J., Rinella, S., Lee, H. G. & Pollyea, D. A., Apr 2 2016, In : Leukemia and Lymphoma. 57, 4, p. 927-934 8 p.

Research output: Contribution to journalArticle

Plasma Cell Neoplasms
Mutation
Preclinical Drug Evaluations
Granulocyte Colony-Stimulating Factor
Cytogenetics
14 Citations (Scopus)

Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

Nair, A., Chung, H. C., Sun, T., Tyagi, S., Dobrolecki, L. E., Dominguez-Vidana, R., Kurley, S. J., Orellana, M., Renwick, A., Henke, D. M., Katsonis, P., Schmitt, E., Chan, D. W., Li, H., Mao, S., Petrovic, I., Creighton, C. J., Gutierrez, C., Dubrulle, J., Stossi, F. & 17 others, Tyner, J., Lichtarge, O., Lin, C. Y., Zhang, B., Scott, K. L., Hilsenbeck, S. G., Sun, J., Yu, X., Osborne, C. K., Schiff, R., Christensen, J. G., Shields, D. J., Rimawi, M. F., Ellis, M. J., Shaw, C. A., Lewis, M. T. & Westbrook, T. F., May 1 2018, In : Nature Medicine. 24, 4, p. 505-511 7 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Receptor Protein-Tyrosine Kinases
Tumors
Therapeutics
Neoplasms
10 Citations (Scopus)

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Richard, N. P., Pippa, R., Cleary, M. M., Puri, A., Tibbitts, D., Mahmood, S., Christensen, D. J., Jeng, S., McWeeney, S., Look, A. T., Chang, B., Tyner, J., Vitek, M. P., Odero, M. D., Sears, R. & Agarwal, A., 2016, In : Oncotarget. 7, 51, p. 84214-84227 14 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Protein Phosphatase 2
Cell Line
Phosphotransferases
2 Citations (Scopus)

Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants

Eide, C. A., Zabriskie, M. S., Savage Stevens, S. L., Antelope, O., Vellore, N. A., Than, H., Schultz, A. R., Clair, P., Bowler, A. D., Pomicter, A. D., Yan, D., Senina, A. V., Qiang, W., Kelley, T. W., Szankasi, P., Heinrich, M. C., Tyner, J. W., Rea, D., Cayuela, J. M., Kim, D. W. & 4 others, Tognon, C. E., O'Hare, T., Druker, B. J. & Deininger, M. W., Oct 14 2019, In : Cancer Cell. 36, 4, p. 431-443.e5

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Adenosine Triphosphate
ponatinib
4 Citations (Scopus)
Precision Medicine
Genes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Small Interfering RNA
Genome
15 Citations (Scopus)

Corepressor Rcor1 is essential for murine erythropoiesis

Yao, H., Goldman, D., Nechiporuk, T., Kawane, S., McWeeney, S., Tyner, J., Fan, G., Kerenyi, M. A., Orkin, S. H., Fleming, W. & Mandel, G., May 15 2014, In : Blood. 123, 20, p. 3175-3184 10 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Erythropoiesis
Genes
Erythroblasts
Colony-Stimulating Factor Receptors
13 Citations (Scopus)

CPX-351 exhibits potent and direct ex vivo cytotoxicity against AML blasts with enhanced efficacy for cells harboring the FLT3-ITD mutation

Gordon, M. J., Tardi, P., Loriaux, M., Spurgeon, S., Traer, E., Kovacsovics, T., Mayer, L. D. & Tyner, J., Feb 1 2017, In : Leukemia Research. 53, p. 39-49 11 p.

Research output: Contribution to journalArticle

Mutation
B-Cell Chronic Lymphocytic Leukemia
Inhibitory Concentration 50
Daunorubicin
Myelodysplastic Syndromes
39 Citations (Scopus)

Crosstalk between KIT and FGFR3 promotes gastrointestinal stromal tumor cell growth and drug resistance

Javidi-Sharifi, N., Traer, E., Martinez, J., Gupta, A., Taguchi, T., Dunlap, J., Heinrich, M., Corless, C., Rubin, B. P., Druker, B. & Tyner, J., Mar 1 2015, In : Cancer Research. 75, 5, p. 880-891 12 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Stromal Cells
Drug Resistance
Growth
Fibroblast Growth Factor 2
95 Citations (Scopus)

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Bicocca, V. T., Chang, B., Masouleh, B. K., Muschen, M., Loriaux, M., Druker, B. & Tyner, J., Nov 13 2012, In : Cancer Cell. 22, 5, p. 656-667 12 p.

Research output: Contribution to journalArticle

Pre-B Cell Receptors
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Phosphorylation
Cell Surface Receptors
Phosphotransferases
6 Citations (Scopus)

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E., Kaempf, A., Mori, M. T., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. & Tyner, J., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Acute Myeloid Leukemia
Macrophage Colony-Stimulating Factor
Cytokines
Cells
131 Citations (Scopus)

CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia

Pardanani, A., Lasho, T. L., Laborde, R. R., Elliott, M., Hanson, C. A., Knudson, R. A., Ketterling, R. P., Maxson, J., Tyner, J. & Tefferi, A., Sep 2013, In : Leukemia. 27, 9, p. 1870-1873 4 p.

Research output: Contribution to journalArticle

Leukemia, Neutrophilic, Chronic
Mutation
Exons
Paraproteinemias
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
33 Citations (Scopus)
Drug Synergism
Naphthyridines
Quinazolinones
Pyrazoles
Vidarabine
151 Citations (Scopus)

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

Tyner, J., Bumm, T. G., Deininger, J., Wood, L., Aichberger, K. J., Loriaux, M., Druker, B., Burns, C. J., Fantino, E. & Deininger, M. W., Jun 24 2010, In : Blood. 115, 25, p. 5232-5240 9 p.

Research output: Contribution to journalArticle

Janus Kinase 2
Cytokines
Neoplasms
TYK2 Kinase
Alleles

Defining and adjusting divergent host responses to viral infection

Holtzman, M. J., Kim, E. Y., Lo, M. S., Tyner, J., Shornick, L. P., Sumino, K. C. & Zhang, Y., 2005, In : Immunologic Research. 32, 1-3, p. 123-141 19 p.

Research output: Contribution to journalArticle

Virus Diseases
Antiviral Agents
Phenotype
Asthma
Infection
22 Citations (Scopus)

Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2

Van Bodegom, D., Zhong, J., Kopp, N., Dutta, C., Kim, M. S., Bird, L., Weigert, O., Tyner, J., Pandey, A., Yoda, A. & Weinstock, D. M., Oct 4 2012, In : Blood. 120, 14, p. 2853-2863 11 p.

Research output: Contribution to journalArticle

B-Cell Leukemia
Oncogene Proteins
Cells
Phosphorylation
Mutation
2 Citations (Scopus)

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, K., Hjorth-Hansen, H., Druker, B., Enserink, J. M., Tyner, J., Mustjoki, S. & Porkka, K., 2017, In : Oncotarget. 8, 14, p. 22606-22615 10 p.

Research output: Contribution to journalArticle

Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Leukemia
Stem Cells
6 Citations (Scopus)

Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia

Watanabe-Smith, K., Tognon, C., Tyner, J., Meijerink, J. P. P., Druker, B. & Agarwal, A., Sep 1 2016, In : Leukemia. 30, 9, p. 1950-1953 4 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Disparate effects of Shb gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia

Jamalpour, M., Li, X., Gustafsson, K., Tyner, J. & Welsh, M., Apr 1 2018, In : Tumor Biology. 40, 4

Research output: Contribution to journalArticle

Deficiency Diseases
T-Cell Leukemia
Myeloid Cells
Leukemia
B-Lymphocytes

DNA distress creates lethal opportunity in MPN

Tyner, J., Dec 28 2017, In : Blood. 130, 26, p. 2814-2816 3 p.

Research output: Contribution to journalReview article

Stem Cells
Double-Stranded DNA Breaks
DNA
Stem cells
DNA Repair

Dual inhibition of JAK1/2 kinases and BCL2: a promising therapeutic strategy for acute myeloid leukemia

Kurtz, S. E., Eide, C. A., Kaempf, A., Mori, M. T., Tognon, C. E., Borate, U., Druker, B. & Tyner, J., Sep 1 2018, In : Leukemia. 32, 9, p. 2025-2028 4 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Phosphotransferases
Therapeutics
16 Citations (Scopus)

Dynamic and nuclear expression of PDGFRα and IGF-1R in alveolar rhabdomyosarcoma

Aslam, M. I., Hettmer, S., Abraham, J., Latocha, D., Soundararajan, A., Huang, E. T., Goros, M. W., Michalek, J. E., Wang, S., Mansoor, A., Druker, B., Wagers, A. J., Tyner, J. & Keller, C., Nov 2013, In : Molecular Cancer Research. 11, 11, p. 1303-1313 11 p.

Research output: Contribution to journalArticle

Alveolar Rhabdomyosarcoma
Platelet-Derived Growth Factor
Somatomedins
Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
15 Citations (Scopus)

Effect of dasatinib against thyroid cancer cell lines in vitro and a xenograft model in vivo

Chan, D., Tyner, J., Chng, W. J., Bi, C., Okamoto, R., Said, J., Ngan, B. D., Braunstein, G. D. & Koeffler, H. P., Apr 2012, In : Oncology Letters. 3, 4, p. 807-815 9 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Heterografts
Cell Line
Cytostatic Agents
Caveolins
6 Citations (Scopus)

EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT

Merchant, A. A., Jorapur, A., McManus, A., Liu, R., Krasnoperov, V., Chaudhry, P., Singh, M., Harton, L., Agajanian, M., Kim, M., Triche, T. J., Druker, B. J., Tyner, J. W. & Gill, P. S., Sep 12 2017, In : Blood Advances. 1, 20, p. 1635-1644 10 p.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia
Cell Survival
Leukemia
Eph Family Receptors
Phosphatidylinositol 3-Kinase

Erratum: Correction: FGF2-FGFR1 signaling regulates release of leukemia-protective exosomes from bone marrow stromal cells (eLife (2019) 8 PII: e47174)

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribeiro, R., Viola, S. K., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Mar 29 2019, In : eLife. 8

Research output: Contribution to journalComment/debate

Open Access
Exosomes
Fibroblast Growth Factor 2
Mesenchymal Stromal Cells
Medicine
Bone

Evaluation of safety in biomarker driven multiple agent phase IB trial

Mori, M. T., Daffé, R., Park, B. & Tyner, J., Oct 3 2017, Frontiers of Biostatistical Methods and Applications in Clinical Oncology. Springer Singapore, p. 53-64 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biomarkers
Inhibitor
Phosphotransferases
Safety
Evaluation
39 Citations (Scopus)

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Frismantas, V., Dobay, M. P., Rinaldi, A., Tchinda, J., Dunn, S. H., Kunz, J., Richter-Pechanska, P., Marovca, B., Pail, O., Jenni, S., Diaz-Flores, E., Chang, B., Brown, T. J., Collins, R. H., Uhrig, S., Balasubramanian, G. P., Bandapalli, O. R., Higi, S., Eugster, S., Voegeli, P. & 17 others, Delorenzi, M., Cario, G., Loh, M. L., Schrappe, M., Stanulla, M., Kulozik, A. E., Muckenthaler, M. U., Saha, V., Irving, J. A., Meisel, R., Radimerski, T., Von Stackelberg, A., Eckert, C., Tyner, J., Horvath, P., Bornhauser, B. C. & Bourquin, J. P., Mar 16 2017, In : Blood. 129, 11, p. e26-e37

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Pharmaceutical Preparations
T-cells