Jeffrey Tyner

Associate Professor

  • 6041 Citations
  • 38 h-Index
20022020

Research output per year

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Research Output

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Article
2020

Simultaneous kinase inhibition with ibrutinib and BCL2 inhibition with venetoclax offers a therapeutic strategy for acute myeloid leukemia

Eide, C. A., Kurtz, S. E., Kaempf, A., Long, N., Agarwal, A., Tognon, C. E., Mori, M., Druker, B. J., Chang, B. H., Danilov, A. V. & Tyner, J. W., Jan 1 2020, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

2019

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. & Tyner, J., Dec 1 2019, In : Nature Communications. 10, 1, 244.

Research output: Contribution to journalArticle

15 Scopus citations

Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants

Eide, C. A., Zabriskie, M. S., Savage Stevens, S. L., Antelope, O., Vellore, N. A., Than, H., Schultz, A. R., Clair, P., Bowler, A. D., Pomicter, A. D., Yan, D., Senina, A. V., Qiang, W., Kelley, T. W., Szankasi, P., Heinrich, M. C., Tyner, J. W., Rea, D., Cayuela, J. M., Kim, D. W. & 4 others, Tognon, C. E., O'Hare, T., Druker, B. J. & Deininger, M. W., Oct 14 2019, In : Cancer Cell. 36, 4, p. 431-443.e5

Research output: Contribution to journalArticle

6 Scopus citations

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E. F., Kaempf, A., Mori, M., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. K. & Tyner, J. W., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribiero, R., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Feb 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma

Choonoo, G., Blucher, A. S., Higgins, S., Boardman, M., Jeng, S., Zheng, C., Jacobs, J., Anderson, A., Chamberlin, S., Evans, N., Vigoda, M., Cordier, B., Tyner, J. W., Kulesz-Martin, M., McWeeney, S. K. & Laderas, T., Jan 1 2019, In : PloS one. 14, 10, e0223639.

Research output: Contribution to journalArticle

Open Access

Predicting response to BET inhibitors using computational modeling: A BEAT AML project study

Drusbosky, L. M., Vidva, R., Gera, S., Lakshminarayana, A. V., Shyamasundar, V. P., Agrawal, A. K., Talawdekar, A., Abbasi, T., Vali, S., Tognon, C. E., Kurtz, S. E., Tyner, J., McWeeney, S., Druker, B. & Cogle, C. R., Feb 1 2019, In : Leukemia Research. 77, p. 42-50 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Proteolysis targeting chimeric molecules as therapy for multiple myeloma: Efficacy, biomarker and drug combinations

Lim, S. L., Damnernsawad, A., Shyamsunder, P., Chng, W. J., Han, B. C., Xu, L., Pan, J., Pravin, D. P., Alkan, S., Tyner, J. W. & Koeffler, H. P., Jan 1 2019, In : Haematologica. 104, 6, p. 1209-1220 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Replication timing alterations in leukemia affect clinically relevant chromosome domains

Rivera-Mulia, J. C., Sasaki, T., Trevilla-Garcia, C., Nakamichi, N., Knapp, D. J. H. F., Hammond, C. A., Chang, B. H., Tyner, J. W., Devidas, M., Zimmerman, J., Klein, K. N., Somasundaram, V., Druker, B. J., Gruber, T. A., Koren, A., Eaves, C. J. & Gilbert, D. M., Nov 12 2019, In : Blood Advances. 3, 21, p. 3201-3213 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells

Sun, Q. Y., Ding, L. W., Johnson, K., Zhou, S., Tyner, J. W., Yang, H., Doan, N. B., Said, J. W., Xiao, J. F., Loh, X. Y., Ran, X. B., Venkatachalam, N., Lao, Z., Chen, Y., Xu, L., Fan, L. F., Chien, W., Lin, D. C. & Koeffler, H. P., Aug 22 2019, In : Oncogene. 38, 34, p. 6196-6210 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting mitochondria in cancer therapy could provide a basis for the selective anticancer activity

Rozanov, D., Cheltsov, A., Nilsen, A., Boniface, C., Forquer, I., Korkola, J., Gray, J., Tyner, J., Tognon, C. E., Mills, G. & Spellman, P., Mar 1 2019, In : PloS one. 14, 3, e0205623.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells

Nechiporuk, T., Kurtz, S. E., Nikolova, O., Liu, T., Jones, C. L., D’alessandro, A., Culp-Hill, R., D’almeida, A., Joshi, S. K., Rosenberg, M., Tognon, C. E., Danilov, A. V., Druker, B. J., Chang, B. H., McWeeney, S. K. & Tyner, J. W., Jul 2019, In : Cancer discovery. 9, 7, p. 910-925 16 p.

Research output: Contribution to journalArticle

14 Scopus citations
2018

ARID1A and CEBPα cooperatively inhibit UCA1 transcription in breast cancer

Guo, X., Zhang, Y., Mayakonda, A., Madan, V., Ding, L. W., Lin, L. H., Zia, S., Gery, S., Tyner, J., Zhou, W., Yin, D., Lin, D. C. & Koeffler, H. P., Jul 6 2018, (Accepted/In press) In : Oncogene. p. 1-13 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

Nair, A., Chung, H. C., Sun, T., Tyagi, S., Dobrolecki, L. E., Dominguez-Vidana, R., Kurley, S. J., Orellana, M., Renwick, A., Henke, D. M., Katsonis, P., Schmitt, E., Chan, D. W., Li, H., Mao, S., Petrovic, I., Creighton, C. J., Gutierrez, C., Dubrulle, J., Stossi, F. & 17 others, Tyner, J., Lichtarge, O., Lin, C. Y., Zhang, B., Scott, K. L., Hilsenbeck, S. G., Sun, J., Yu, X., Osborne, C. K., Schiff, R., Christensen, J. G., Shields, D. J., Rimawi, M. F., Ellis, M. J., Shaw, C. A., Lewis, M. T. & Westbrook, T. F., May 1 2018, In : Nature Medicine. 24, 4, p. 505-511 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Disparate effects of Shb gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia

Jamalpour, M., Li, X., Gustafsson, K., Tyner, J. & Welsh, M., Apr 1 2018, In : Tumor Biology. 40, 4

Research output: Contribution to journalArticle

1 Scopus citations

Dual inhibition of JAK1/2 kinases and BCL2: a promising therapeutic strategy for acute myeloid leukemia

Kurtz, S. E., Eide, C. A., Kaempf, A., Mori, M., Tognon, C. E., Borate, U., Druker, B. J. & Tyner, J. W., Sep 1 2018, In : Leukemia. 32, 9, p. 2025-2028 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Functional genomic landscape of acute myeloid leukaemia

Tyner, J. W., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B. H., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K. H. T., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M. M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S. E., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. K. & Druker, B. J., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

90 Scopus citations

Gain-of-function mutations in granulocyte colony–stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation

Zhang, H., Coblentz, C., Watanabe-Smith, K., Means, S., Means, J., Maxson, J. & Tyner, J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 19, p. 7387-7396 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models

Ouyang, X., Barling, A., Lesch, A., Tyner, J., Choonoo, G., Zheng, C., Jeng, S., West, T. M., Clayburgh, D., Courtneidge, S., McWeeney, S. & Kulesz-Martin, M., Oct 3 2018, In : Cancer Biology and Therapy. 19, 10, p. 921-933 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma

Klug, L. R., Bannon, A. E., Javidi-Sharifi, N., Town, A., Fleming, W., VanSlyke, J. K., Musil, L., Fletcher, J. A., Tyner, J. & Heinrich, M., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

2 Scopus citations

Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL

Chow, M., Gao, L., MacManiman, J. D., Bicocca, V. T., Chang, B., Alumkal, J. & Tyner, J., May 30 2018, (Accepted/In press) In : Oncogene. p. 1-12 12 p.

Research output: Contribution to journalArticle

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

Jenkins, C., Luty, S. B., Maxson, J., Eide, C. A., Abel, M. L., Togiai, C., Nemecek, E., Bottomly, D., McWeeney, S., Wilmot, B., Loriaux, M., Chang, B. & Tyner, J., Jul 17 2018, In : Science Signaling. 11, 539, eaao5617.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A., Lee, P., Chantry, D., McWeeney, S., Druker, B., Tyner, J., Spurgeon, S. & Loriaux, M., May 15 2018, In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Two myeloid leukemia cases with rare FLT3 fusions

Zhang, H., Paliga, A., Hobbs, E., Moore, S., Olson, S., Long, N., Dao, K-H. & Tyner, J., Dec 1 2018, In : Cold Spring Harbor molecular case studies. 4, 6

Research output: Contribution to journalArticle

2 Scopus citations
2017

BCL6 promotes glioma and serves as a therapeutic target

Xu, L., Chen, Y., Dutra-Clarke, M., Mayakonda, A., Hazawa, M., Savinoff, S. E., Doan, N., Said, J. W., Yong, W. H., Watkins, A., Yang, H., Ding, L. W., Jiang, Y. Y., Tyner, J. W., Ching, J., Kovalik, J. P., Madan, V., Chan, S. L., Müschen, M., Breunig, J. J. & 3 others, Lin, D. C., Koeffler, H. P. & Cavenee, W. K., Jan 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 15

Research output: Contribution to journalArticle

19 Scopus citations

Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations

Zhang, H., Reister Schultz, A., Luty, S., Rofelty, A., Su, Y., Means, S., Bottomly, D., Wilmot, B., McWeeney, S. & Tyner, J., Dec 1 2017, In : Leukemia. 31, 12, p. 2752-2760 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia

Bandyopadhyay, S., Li, J., Traer, E., Tyner, J. W., Zhou, A., Oh, S. T. & Cheng, J. X., Jul 2017, In : PloS one. 12, 7, e0179558.

Research output: Contribution to journalArticle

10 Scopus citations

CPX-351 exhibits potent and direct ex vivo cytotoxicity against AML blasts with enhanced efficacy for cells harboring the FLT3-ITD mutation

Gordon, M. J., Tardi, P., Loriaux, M., Spurgeon, S., Traer, E., Kovacsovics, T., Mayer, L. D. & Tyner, J., Feb 1 2017, In : Leukemia Research. 53, p. 39-49 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, K., Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., Jan 1 2017, In : Oncotarget. 8, 14, p. 22606-22615 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT

Merchant, A. A., Jorapur, A., McManus, A., Liu, R., Krasnoperov, V., Chaudhry, P., Singh, M., Harton, L., Agajanian, M., Kim, M., Triche, T. J., Druker, B. J., Tyner, J. W. & Gill, P. S., Sep 12 2017, In : Blood Advances. 1, 20, p. 1635-1644 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Frismantas, V., Dobay, M. P., Rinaldi, A., Tchinda, J., Dunn, S. H., Kunz, J., Richter-Pechanska, P., Marovca, B., Pail, O., Jenni, S., Diaz-Flores, E., Chang, B., Brown, T. J., Collins, R. H., Uhrig, S., Balasubramanian, G. P., Bandapalli, O. R., Higi, S., Eugster, S., Voegeli, P. & 17 others, Delorenzi, M., Cario, G., Loh, M. L., Schrappe, M., Stanulla, M., Kulozik, A. E., Muckenthaler, M. U., Saha, V., Irving, J. A., Meisel, R., Radimerski, T., Von Stackelberg, A., Eckert, C., Tyner, J., Horvath, P., Bornhauser, B. C. & Bourquin, J. P., Mar 16 2017, In : Blood. 129, 11, p. e26-e37

Research output: Contribution to journalArticle

40 Scopus citations

Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma

Sun, H., Lin, D. C., Cao, Q., Pang, B., Gae, D. D., Lee, V. K. M., Lim, H. J., Doan, N., Said, J. W., Gery, S., Chow, M., Mayakonda, A., Forscher, C., Tyner, J. & Koeffler, H. P., Aug 1 2017, In : Clinical Cancer Research. 23, 15, p. 4376-4387 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

Carey, A., Edwards, D. K., Eide, C. A., Newell, L., Traer, E., Medeiros, B. C., Pollyea, D. A., Deininger, M. W., Collins, R. H., Tyner, J., Druker, B., Bagby, G. C., McWeeney, S. & Agarwal, A., Mar 28 2017, In : Cell Reports. 18, 13, p. 3204-3218 15 p.

Research output: Contribution to journalArticle

53 Scopus citations

Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets

Kanojia, D., Garg, M., Martinez, J., Anand, M. T., Luty, S. B., Doan, N. B., Said, J. W., Forscher, C., Tyner, J. W. & Koeffler, H. P., Nov 13 2017, In : Journal of Hematology and Oncology. 10, 1, 173.

Research output: Contribution to journalArticle

2 Scopus citations

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade

Lue, H. W., Podolak, J., Kolahi, K., Cheng, L., Rao, S., Garg, D., Xue, C. H., Rantala, J. K., Tyner, J., Thornburg, K., Martinez-Acevedo, A., Liu, J-J., Amling, C., Truillet, C., Louie, S. M., Anderson, K. E., Evans, M. J., O’Donnell, V. B., Nomura, D. K., Drake, J. M. & 2 others, Ritz, A. & Thomas, G., Oct 15 2017, In : Genes and Development. 31, 20, p. 2067-2084 18 p.

Research output: Contribution to journalArticle

17 Scopus citations

Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies

Kurtz, S. E., Eide, C. A., Kaempf, A., Khanna, V., Savage, S. L., Rofelty, A., English, I., Ho, H., Pandya, R., Bolosky, W. J., Poon, H., Deininger, M. W., Collins, R., Swords, R. T., Watts, J., Pollyea, D. A., Medeiros, B. C., Traer, E., Tognon, C. E., Mori, M. & 2 others, Druker, B. J. & Tyner, J. W., Sep 5 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 36, p. E7554-E7563

Research output: Contribution to journalArticle

34 Scopus citations

PlGF enhances TLR-dependent inflammatory responses in human mononuclear phagocytes

Newell, L., Holtan, S. G., Yates, J. E., Pereira, L., Tyner, J., Burd, I. & Bagby, G. C., 2017, (Accepted/In press) In : American Journal of Reproductive Immunology.

Research output: Contribution to journalArticle

4 Scopus citations

Recent Progress in Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia

Dao, K-H., Tyner, J. & Gotlib, J., Oct 6 2017, (Accepted/In press) In : Current Hematologic Malignancy Reports. p. 1-10 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer

Weber, H., Valbuena, J. R., Barbhuiya, M. A., Stein, S., Kunkel, H., García, P., Bizama, C., Riquelme, I., Espinoza, J. A., Kurtz, S. E., Tyner, J. W., Calderon, J. F., Corvalán, A. H., Grez, M., Pandey, A., Leal-Rojas, P. & Roa, J. C., Jan 1 2017, In : Oncotarget. 8, 16, p. 26169-26184 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia

Sasaki, T., Rivera-Mulia, J. C., Vera, D., Zimmerman, J., Das, S., Padget, M., Nakamichi, N., Chang, B., Tyner, J., Druker, B., Weng, A. P., Civin, C. I., Eaves, C. J. & Gilbert, D. M., Jul 1 2017, In : Experimental Hematology. 51, p. 71-82.e3

Research output: Contribution to journalArticle

15 Scopus citations

Super-enhancers promote transcriptional dysregulation in nasopharyngeal carcinoma

Yuan, J., Jiang, Y. Y., Mayakonda, A., Huang, M., Ding, L. W., Lin, H., Yu, F., Lu, Y., Loh, T. K. S., Chow, M., Savage, S., Tyner, J., Lin, D. C. & Koeffler, H. P., Dec 1 2017, In : Cancer Research. 77, 23, p. 6614-6626 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Targeting super-enhancer-Associated oncogenes in oesophageal squamous cell carcinoma

Jiang, Y. Y., Lin, D. C., Mayakonda, A., Hazawa, M., Ding, L. W., Chien, W. W., Xu, L., Chen, Y., Xiao, J. F., Senapedis, W., Baloglu, E., Kanojia, D., Shang, L., Xu, X., Yang, H., Tyner, J. W., Wang, M. R. & Koeffler, H. P., Aug 1 2017, In : Gut. 66, 8, p. 1358-1368 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

UNC2025, a MERTK small-molecule inhibitor, is therapeutically effective alone and in combination with methotrexate in leukemia models

DeRyckere, D., Lee-Sherick, A. B., Huey, M. G., Hill, A. A., Tyner, J. W., Jacobsen, K. M., Page, L. S., Kirkpatrick, G. G., Eryildiz, F., Montgomery, S. A., Zhang, W., Wang, X., Frye, S. V., Earp, H. S. & Graham, D. K., Mar 15 2017, In : Clinical Cancer Research. 23, 6, p. 1481-1492 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Unpaired extracellular cysteine mutations of CSF3R mediate gain or loss of function

Zhang, H., Means, S., Schultz, A. R., Watanabe-Smith, K., Medeiros, B. C., Bottomly, D., Wilmot, B., McWeeney, S., Kükenshöner, T., Hantschel, O. & Tyner, J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4258-4267 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016
26 Scopus citations

Clonality of neutrophilia associated with plasma cell neoplasms: Report of a SETBP1 mutation and analysis of a single institution series

Stevens, B., Maxson, J., Tyner, J., Smith, C. A., Gutman, J. A., Robinson, W., Jordan, C. T., Lee, C. K., Swisshelm, K., Tobin, J., Wei, Q., Schowinsky, J., Rinella, S., Lee, H. G. & Pollyea, D. A., Apr 2 2016, In : Leukemia and Lymphoma. 57, 4, p. 927-934 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Richard, N. P., Pippa, R., Cleary, M. M., Puri, A., Tibbitts, D., Mahmood, S., Christensen, D. J., Jeng, S., McWeeney, S., Look, A. T., Chang, B., Tyner, J., Vitek, M. P., Odero, M. D., Sears, R. & Agarwal, A., 2016, In : Oncotarget. 7, 51, p. 84214-84227 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

FGF2 from marrow microenvironment promotes resistance to FLT3 inhibitors in acute myeloid leukemia

Traer, E., Martinez, J., Javidi-Sharifi, N., Agarwal, A., Dunlap, J., English, I., Kovacsovics, T., Tyner, J., Wong, M. & Druker, B., Nov 15 2016, In : Cancer Research. 76, 22, p. 6471-6482 12 p.

Research output: Contribution to journalArticle

28 Scopus citations
7 Scopus citations

Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis

Maxson, J., Abel, M. L., Wang, J., Deng, X., Reckel, S., Luty, S. B., Sun, H., Gorenstein, J., Hughes, S. B., Bottomly, D., Wilmot, B., McWeeney, S., Radich, J., Hantschel, O., Middleton, R. E., Gray, N. S., Druker, B. & Tyner, J., Jan 1 2016, In : Cancer Research. 76, 1, p. 127-138 12 p.

Research output: Contribution to journalArticle

15 Scopus citations