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Jeffrey Tyner

Associate Professor

  • 5917 Citations
  • 37 h-Index
20022020

Research output per year

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Projects

Targeting PTPN11 dependent Hematologic Malignancies

Chang, B. & Tyner, J.

Project: Research project

Tumor Intrinsic and Microenvironmental Mechanisms Driving Drug Combination Efficacy and Resistance in AML

Druker, B., Tyner, J. & Agarwal, A.

Project: Research project

Functional Genomic Discovery of Pathway Targeted and Immune Modulatory Therapeutic Combinations in Hematologic Malignancies

Druker, B. & Tyner, J.

Project: Research project

Pathogenetic Mechanism and Clinical Targeting of CSF3R-Driven Cancer

Tyner, J.

National Institutes of Health

4/1/14 → 2/28/19

Project: Research project

    • ROR1 as a Therapeutic Target in Acute Lymphoblastic Leukemia

    Tyner, J.

    National Institutes of Health

    9/1/10 → 8/31/16

    Project: Research project

    • Research Output

    Simultaneous kinase inhibition with ibrutinib and BCL2 inhibition with venetoclax offers a therapeutic strategy for acute myeloid leukemia

    Eide, C. A., Kurtz, S. E., Kaempf, A., Long, N., Agarwal, A., Tognon, C. E., Mori, M., Druker, B. J., Chang, B. H., Danilov, A. V. & Tyner, J. W., Jan 1 2020, (Accepted/In press) In : Leukemia.

    Research output: Contribution to journal › Article

    • Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

    Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. & Tyner, J., Dec 1 2019, In : Nature Communications. 10, 1, 244.

    Research output: Contribution to journal › Article

    • 15 Scopus citations

    Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants

    Eide, C. A., Zabriskie, M. S., Savage Stevens, S. L., Antelope, O., Vellore, N. A., Than, H., Schultz, A. R., Clair, P., Bowler, A. D., Pomicter, A. D., Yan, D., Senina, A. V., Qiang, W., Kelley, T. W., Szankasi, P., Heinrich, M. C., Tyner, J. W., Rea, D., Cayuela, J. M., Kim, D. W. & 4 others, Tognon, C. E., O'Hare, T., Druker, B. J. & Deininger, M. W., Oct 14 2019, In : Cancer Cell. 36, 4, p. 431-443.e5

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

    Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E., Kaempf, A., Mori, M. T., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. & Tyner, J., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

    Research output: Contribution to journal › Article

    • 6 Scopus citations

    Erratum: Correction: FGF2-FGFR1 signaling regulates release of leukemia-protective exosomes from bone marrow stromal cells (eLife (2019) 8 PII: e47174)

    Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribeiro, R., Viola, S. K., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Mar 29 2019, In : eLife. 8

    Research output: Contribution to journal › Comment/debate

    Open Access