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Jeffrey Tyner

Associate Professor

  • 4376 Citations
  • 30 h-Index
20022019

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Mutation Medicine & Life Sciences
Acute Myeloid Leukemia Medicine & Life Sciences
Protein-Tyrosine Kinases Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Leukemia Medicine & Life Sciences
Leukemia, Neutrophilic, Chronic Medicine & Life Sciences
Colony-Stimulating Factor Receptors Medicine & Life Sciences

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Projects 2010 2019

Pathogenetic Mechanism and Clinical Targeting of CSF3R-Driven Cancer

Tyner, J.

National Institutes of Health

4/1/14 → 2/28/19

Project: Research project › Research Project

Leukemia, Neutrophilic, Chronic
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mutation
Neoplasms
Phosphotransferases

ROR1 as a Therapeutic Target in Acute Lymphoblastic Leukemia

Tyner, J.

National Institutes of Health

9/1/10 → 8/31/16

Project: Research project › Career Transition Award, Research Transition Award

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Research
Neoplasms
Genes
Therapeutics

Research Output 2002 2018

A novel AGGF1-PDGFRβ fusion in pediatric T-cell acute lymphoblastic leukemia

Zabriskie, M. S., Antelope, O., Verma, A. R., Draper, L. R., Eide, C. A., Pomicter, A. D., Tran, T. H., Druker, B. J., Tyner, J. W., Miles, R. R., Graham, J. M., Hwang, J. Y., Varley, K. E., Toydemir, R. M., Deininger, M. W., Raetz, E. A. & O’Hare, T. Jan 31 2018 In : Haematologica. 103, 2, p. e87-e91

Research output: Contribution to journal › Comment/debate

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics

Disparate effects of Shb gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia

Jamalpour, M., Li, X., Gustafsson, K., Tyner, J. W. & Welsh, M. Apr 1 2018 In : Tumor Biology. 40, 4

Research output: Contribution to journal › Article

Deficiency Diseases
T-Cell Leukemia
Myeloid Cells
Leukemia
B-Lymphocytes

Gain-of-function mutations in granulocyte colony–stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation

Zhang, H., Coblentz, C., Watanabe-Smith, K., Means, S., Means, J., Maxson, J. E. & Tyner, J. W. Jan 1 2018 In : Journal of Biological Chemistry. 293, 19, p. 7387-7396 10 p.

Research output: Contribution to journal › Article

Granulocyte Colony-Stimulating Factor Receptors
Granulocyte Colony-Stimulating Factor
Chemical activation
Coagulation
Mutation

Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL

Chow, M., Gao, L., MacManiman, J. D., Bicocca, V. T., Chang, B. H., Alumkal, J. J. & Tyner, J. W. May 30 2018 (Accepted/In press) In : Oncogene. p. 1-12 12 p.

Research output: Contribution to journal › Article

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Protein Transport
B-Lymphoid Precursor Cells
Maintenance
Proteasome Endopeptidase Complex

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A. V., Lee, P., Chantry, D., McWeeney, S. K., Druker, B. J., Tyner, J. W., Spurgeon, S. E. & Loriaux, M. M. May 15 2018 In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journal › Article

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
B-Cell Chronic Lymphocytic Leukemia
Antineoplastic Agents
Monocytes