Jeffrey Tyner

Associate Professor

  • 5854 Citations
  • 37 h-Index
20022019
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Research Output 2002 2019

2013
77 Citations (Scopus)

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

Davare, M., Saborowski, A., Eide, C. A., Tognon, C., Smith, R. L., Elferich, J., Agarwal, A., Tyner, J., Shinde, U., Lowe, S. W. & Druker, B., Nov 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19519-19524 6 p.

Research output: Contribution to journalArticle

Proteins
Lung Neoplasms
Phosphotransferases
Cholangiocarcinoma
Glioblastoma
6 Citations (Scopus)

HitWalker: Variant prioritization for personalized functional cancer genomics

Bottomly, D., Wilmot, B., Tyner, J., Eide, C. A., Loriaux, M., Druker, B. & McWeeney, S., Feb 15 2013, In : Bioinformatics. 29, 4, p. 509-510 2 p.

Research output: Contribution to journalArticle

Prioritization
Genomics
Cancer
Program documentation
Proteins
18 Citations (Scopus)

Imatinib and dasatinib inhibit hemangiosarcoma and implicate PDGFR-β and Src in tumor growth

Dickerson, E. B., Marley, K., Edris, W., Tyner, J., Schalk, V., MacDonald, V., Loriaux, M., Druker, B. & Helfand, S. C., Apr 2013, In : Translational Oncology. 6, 2, p. 158-168 11 p.

Research output: Contribution to journalArticle

Hemangiosarcoma
Protein-Tyrosine Kinases
Growth
Neoplasms
Phosphorylation
88 Citations (Scopus)

Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening

Tyner, J., Yang, W. F., Bankhead, A., Fan, G., Fletcher, L. B., Bryant, J., Glover, J. M., Chang, B., Spurgeon, S., Fleming, W., Kovacsovics, T., Gotlib, J. R., Oh, S. T., Deininger, M. W., Zwaan, C. M., Den Boer, M. L., Van Den Heuvel-Eibrink, M. M., O'Hare, T., Druker, B. & Loriaux, M., Jan 1 2013, In : Cancer Research. 73, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

Leukemia
Phosphotransferases
Pharmaceutical Preparations
High-Throughput Nucleotide Sequencing
Mutation
2 Citations (Scopus)

Next-generation medicine: Combining BCR-ABL and hedgehog-targeted therapies

Dao, K-H. & Tyner, J., Mar 15 2013, In : Clinical Cancer Research. 19, 6, p. 1309-1311 3 p.

Research output: Contribution to journalArticle

Leukemia
Medicine
Cause of Death
Phosphotransferases
Stem Cells
278 Citations (Scopus)

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

Maxson, J., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., Bottomly, D., Wilmot, B., McWeeney, S., Tognon, C. E., Pond, J. B., Collins, R. H., Goueli, B., Stephen, T. O., Michael, W. D., Chang, B., Loriaux, M., Druker, B. & Tyner, J., 2013, In : New England Journal of Medicine. 368, 19, p. 1781-1790 10 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Leukemia, Neutrophilic, Chronic
Mutation
Phosphotransferases
Neoplasms
59 Citations (Scopus)

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in Mice that is responsive to therapeutic JAK inhibition

Fleischman, A. G., Maxson, J., Luty, S. B., Agarwal, A., Royer, L. R., Abel, M. L., Macmaniman, J. D., Loriaux, M., Druker, B. & Tyner, J., Nov 21 2013, In : Blood. 122, 22, p. 3628-3631 4 p.

Research output: Contribution to journalArticle

Myeloproliferative Disorders
Leukemia, Neutrophilic, Chronic
Mutation
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Spleen
94 Citations (Scopus)

The new genetics of chronic neutrophilic leukemia and atypical CML: Implications for diagnosis and treatment

Gotlib, J., Maxson, J., George, T. I. & Tyner, J., Sep 5 2013, In : Blood. 122, 10, p. 1707-1711 5 p.

Research output: Contribution to journalArticle

Leukemia, Neutrophilic, Chronic
Granulocyte Colony-Stimulating Factor Receptors
Janus Kinase 2
Emitter coupled logic circuits
Protein-Tyrosine Kinases
2 Citations (Scopus)

The PI3K/Akt1 pathway enhances steady-state levels of FANCL

Dao, K-H., Rotelli, M. D., Brown, B. R., Yates, J. E., Rantala, J., Tognon, C., Tyner, J., Druker, B. & Bagby, G. C., Aug 15 2013, In : Molecular Biology of the Cell. 24, 16, p. 2582-2592 11 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Fanconi Anemia
Fanconi Anemia Complementation Group L Protein
Hematopoietic Stem Cells
Phosphatidylinositol 3-Kinases
31 Citations (Scopus)

The selective syk inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemias

Spurgeon, S., Coffey, G., Fletcher, L. B., Burke, R., Tyner, J., Druker, B., Betz, A., DeGuzman, F., Pak, Y., Baker, D., Pandey, A., Hollenbach, S. J., Sinha, U. & Loriaux, M., Feb 2013, In : Journal of Pharmacology and Experimental Therapeutics. 344, 2, p. 378-387 10 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Non-Hodgkin's Lymphoma
Phosphotransferases
Neoplasms
17 Citations (Scopus)

Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells determine their commitment to apoptosis

O'Hare, T., Eide, C. A., Agarwal, A., Adrian, L. T., Zabriskie, M. S., MacKenzie, R. J., La Tocha, D. H., Johnson, K. J., You, H., Luo, J., Riddle, S. M., Marks, B. D., Vogel, K. W., Koop, D., Apgar, J., Tyner, J., Deininger, M. W. & Druker, B., Jun 1 2013, In : Cancer Research. 73, 11, p. 3356-3370 15 p.

Research output: Contribution to journalArticle

Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Apoptosis
Phosphotransferases
74 Citations (Scopus)

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia

Sanda, T., Tyner, J., Gutierrez, A., Ngo, V. N., Glover, J., Chang, B., Yost, A., Ma, W., Fleischman, A. G., Zhou, W., Yang, Y., Kleppe, M., Ahn, Y., Tatarek, J., Kelliher, M. A., Neuberg, D. S., Levine, R. L., Moriggl, R., Müller, M., Gray, N. S. & 5 others, Jamieson, C. H. M., Weng, A. P., Staudt, L. M., Druker, B. & Thomas Look, A., May 2013, In : Cancer Discovery. 3, 5, p. 564-577 14 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
RNA Interference
Protein-Tyrosine Kinases
Proto-Oncogene Proteins c-bcl-2
Cell Survival
2012
11 Citations (Scopus)

An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma

Abraham, J., Chua, Y. X., Glover, J. M., Tyner, J., Loriaux, M., Kilcoyne, A., Giles, F. J., Nelon, L. D., Carew, J. S., Ouyang, Y., Michalek, J. E., Pal, R., Druker, B., Rubin, B. P. & Keller, C., Sep 28 2012, In : Biochemical and Biophysical Research Communications. 426, 3, p. 363-368 6 p.

Research output: Contribution to journalArticle

Alveolar Rhabdomyosarcoma
Rhabdomyosarcoma
Tumors
Cell culture
Primary Cell Culture
95 Citations (Scopus)

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Bicocca, V. T., Chang, B., Masouleh, B. K., Muschen, M., Loriaux, M., Druker, B. & Tyner, J., Nov 13 2012, In : Cancer Cell. 22, 5, p. 656-667 12 p.

Research output: Contribution to journalArticle

Pre-B Cell Receptors
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Phosphorylation
Cell Surface Receptors
Phosphotransferases
22 Citations (Scopus)

Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2

Van Bodegom, D., Zhong, J., Kopp, N., Dutta, C., Kim, M. S., Bird, L., Weigert, O., Tyner, J., Pandey, A., Yoda, A. & Weinstock, D. M., Oct 4 2012, In : Blood. 120, 14, p. 2853-2863 11 p.

Research output: Contribution to journalArticle

B-Cell Leukemia
Oncogene Proteins
Cells
Phosphorylation
Mutation
15 Citations (Scopus)

Effect of dasatinib against thyroid cancer cell lines in vitro and a xenograft model in vivo

Chan, D., Tyner, J., Chng, W. J., Bi, C., Okamoto, R., Said, J., Ngan, B. D., Braunstein, G. D. & Koeffler, H. P., Apr 2012, In : Oncology Letters. 3, 4, p. 807-815 9 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Heterografts
Cell Line
Cytostatic Agents
Caveolins
14 Citations (Scopus)
Gene Rearrangement
Precursor Cell Lymphoblastic Leukemia-Lymphoma
B-Lymphoid Precursor Cells
Stem Cells
Therapeutics

JAK2 V617F down-modulates MPL

Fleischman, A. G. & Tyner, J., May 17 2012, In : Blood. 119, 20, p. 4579-4580 2 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia

Bains, T., Heinrich, M., Loriaux, M., Beadling, C., Nelson, D., Warrick, A., Neff, T. L., Tyner, J., Dunlap, J., Corless, C. & Fan, G., Sep 2012, In : Leukemia. 26, 9, p. 2144-2146 3 p.

Research output: Contribution to journalArticle

Janus Kinase 3
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Mutation
25 Citations (Scopus)

p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC and FANCA-deficient mononuclear phagocytes

Anur, P., Yates, J., Garbati, M. R., Vanderwerf, S., Keeble, W., Rathbun, K., Hays, L. E., Tyner, J., Svahn, J., Cappelli, E., Dufour, C. & Bagby, G. C., Mar 1 2012, In : Blood. 119, 9, p. 1992-2002 11 p.

Research output: Contribution to journalArticle

Fanconi Anemia
p38 Mitogen-Activated Protein Kinases
Phagocytes
Macrophages
Phenotype
35 Citations (Scopus)

Targeting survivin and p53 in pediatric acute lymphoblastic leukemia

Tyner, J., Jemal, A. M., Thayer, M. M., Druker, B. & Chang, B., Apr 2012, In : Leukemia. 26, 4, p. 623-632 10 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics
Cell Line
Inhibitor of Apoptosis Proteins
Philadelphia Chromosome
38 Citations (Scopus)

TSLP signaling network revealed by SILAC-based phosphoproteomics.

Zhong, J., Kim, M. S., Chaerkady, R., Wu, X., Huang, T. C., Getnet, D., Mitchell, C. J., Palapetta, S. M., Sharma, J., O'Meally, R. N., Cole, R. N., Yoda, A., Moritz, A., Loriaux, M., Rush, J., Weinstock, D. M., Tyner, J. & Pandey, A., Jun 2012, In : Molecular & cellular proteomics : MCP. 11, 6

Research output: Contribution to journalArticle

Isotope Labeling
thymic stromal lymphopoietin
Phosphorylation
src-Family Kinases
Cell culture
2011
509 Citations (Scopus)

CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Lannutti, B. J., Meadows, S. A., Herman, S. E. M., Kashishian, A., Steiner, B., Johnson, A. J., Byrd, J. C., Tyner, J., Loriaux, M., Deininger, M., Druker, B., Puri, K. D., Ulrich, R. G. & Giese, N. A., Jan 13 2011, In : Blood. 117, 2, p. 591-594 4 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Phosphatidylinositol 3-Kinases
B-Lymphocytes
Cells
Neoplasms
Therapeutics
91 Citations (Scopus)

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies

Gozgit, J. M., Wong, M. J., Wardwell, S., Tyner, J., Loriaux, M., Mohemmad, Q. K., Narasimhan, N. I., Shakespeare, W. C., Wang, F., Druker, B., Clackson, T. & Rivera, V. M., Jun 2011, In : Molecular Cancer Therapeutics. 10, 6, p. 1028-1035 8 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Acute Myeloid Leukemia
Receptor, Fibroblast Growth Factor, Type 1
Platelet-Derived Growth Factor Receptors
Inhibitory Concentration 50
1 Citation (Scopus)

Rapid identification of therapeutic targets in hematologic malignancies via functional genomics

Tyner, J., 2011, In : Therapeutic Advances in Hematology. 2, 2, p. 83-93 11 p.

Research output: Contribution to journalReview article

Hematologic Neoplasms
Genomics
Genes
Pharmaceutical Preparations
Therapeutics
73 Citations (Scopus)

The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile

Eide, C. A., Adrian, L. T., Tyner, J., Partlin, M. M., Anderson, D. J., Wise, S. C., Smith, B. D., Petillo, P. A., Flynn, D. L., Deininger, M. W. N., O'Hare, T. & Druker, B., May 1 2011, In : Cancer Research. 71, 9, p. 3189-3195 7 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Phosphotransferases
Mutagenesis
Mutation
Inhibitory Concentration 50
2010
151 Citations (Scopus)

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

Tyner, J., Bumm, T. G., Deininger, J., Wood, L., Aichberger, K. J., Loriaux, M., Druker, B., Burns, C. J., Fantino, E. & Deininger, M. W., Jun 24 2010, In : Blood. 115, 25, p. 5232-5240 9 p.

Research output: Contribution to journalArticle

Janus Kinase 2
Cytokines
Neoplasms
TYK2 Kinase
Alleles
54 Citations (Scopus)

MET receptor sequence variants R970C and T992I lack transforming capacity

Tyner, J., Fletcher, L. B., Wang, E. Q., Yang, W. F., Rutenberg-Schoenberg, M. L., Beadling, C., Mori, M. T., Heinrich, M., Deininger, M. W., Druker, B. & Loriaux, M., Aug 1 2010, In : Cancer Research. 70, 15, p. 6233-6237 5 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Leukemia, Myelomonocytic, Chronic
Proto-Oncogene Proteins c-met
Mutation
Poisons
11 Citations (Scopus)

The function of the pleckstrin homology domain in BCR-ABL-mediated leukemogenesis

Demehri, S., O'Hare, T., Eide, C. A., Smith, C. A., Tyner, J., Druker, B. & Deininger, M. W. N., Jan 2010, In : Leukemia. 24, 1, p. 226-229 4 p.

Research output: Contribution to journalArticle

bcr-abl Fusion Proteins
STAT6 Transcription Factor
Phosphoproteins
Tertiary Protein Structure
Blood Proteins
2009
702 Citations (Scopus)

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

O'Hare, T., Shakespeare, W. C., Zhu, X., Eide, C. A., Rivera, V. M., Wang, F., Adrian, L. T., Zhou, T., Huang, W. S., Xu, Q., Metcalf, C. A., Tyner, J., Loriaux, M., Corbin, A. S., Wardwell, S., Ning, Y., Keats, J. A., Wang, Y., Sundaramoorthi, R., Thomas, M. & 8 others, Zhou, D., Snodgrass, J., Commodore, L., Sawyer, T. K., Dalgarno, D. C., Deininger, M. W. N., Druker, B. & Clackson, T., Nov 6 2009, In : Cancer Cell. 16, 5, p. 401-412 12 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mutation
Phosphotransferases
Therapeutics
Mutagenesis
4 Citations (Scopus)

Functional characterization of an activating TEK mutation in acute myeloid leukemia: A cellular context-dependent activating mutation

Tyner, J., Rutenberg-Schoenberg, M. L., Erickson, H., Willis, S. G., O'Hare, T., Deininger, M. W., Druker, B. & Loriaux, M., 2009, In : Leukemia. 23, 7, p. 1345-1348 4 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Mutation
9 Citations (Scopus)

High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia

Tyner, J., Loriaux, M., Erickson, H., Eide, C. A., Deininger, J., MacPartlin, M., Willis, S. G., Lange, T., Druker, B., Kovacsovics, T., Maziarz, R., Gattermann, N. & Deininger, M. W., 2009, In : Leukemia. 23, 2, p. 406-409 4 p.

Research output: Contribution to journalArticle

DNA Mutational Analysis
Leukemia, Myelomonocytic, Chronic
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Proteomics
Protein-Tyrosine Kinases
87 Citations (Scopus)

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

Tyner, J., Erickson, H., Deininger, M. W. N., Willis, S. G., Eide, C. A., Levine, R. L., Heinrich, M., Gattermann, N., Gilliland, D. G., Druker, B. & Loriaux, M., Feb 19 2009, In : Blood. 113, 8, p. 1749-1755 7 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Exons
Assays
Screening
Throughput
78 Citations (Scopus)

RNAi screen for rapid therapeutic target identification in leukemia patients

Tyner, J., Deininger, M. W., Loriaux, M., Chang, B., Gotli, J. R., Willis, S. G., Erickson, H., Kovacsovics, T., O'Hare, T., Heinrich, M. & Druker, B., May 26 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 21, p. 8695-8700 6 p.

Research output: Contribution to journalArticle

RNA Interference
Leukemia
Thrombopoietin Receptors
Genome
Technology
5 Citations (Scopus)

RNAi screen for therapeutic target in leukemia

Tyner, J. & Druker, B., Jul 15 2009, In : Cell Cycle. 8, 14, p. 2144 1 p.

Research output: Contribution to journalArticle

Leukemia
RNAi Therapeutics
2008
8 Citations (Scopus)

Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate

Chou, C. J., O'Hare, T., Lefebvre, S., Alvarez, D., Tyner, J., Eide, C. A., Druker, B. & Gottesfeld, J. M., Oct 31 2008, In : PLoS One. 3, 10, e3593.

Research output: Contribution to journalArticle

Chlorambucil
myeloid leukemia
Nylons
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
phosphotransferases (kinases)
76 Citations (Scopus)

High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

Loriaux, M., Levine, R. L., Tyner, J., Fröhling, S., Scholl, C., Stoffregen, E. P., Wernig, G., Erickson, H., Eide, C. A., Berger, R., Bernard, O. A., Griffin, J. D., Stone, R. M., Lee, B., Meyerson, M., Heinrich, M., Deininger, M. W., Gilliland, D. G. & Druker, B., May 1 2008, In : Blood. 111, 9, p. 4788-4796 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Sequence Analysis
Tyrosine
Alleles
361 Citations (Scopus)

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

Kim, E. Y., Battaile, J. T., Patel, A. C., You, Y., Agapov, E., Grayson, M. H., Benoit, L. A., Byers, D. E., Alevy, Y., Tucker, J., Swanson, S., Tidwell, R., Tyner, J., Morton, J. D., Castro, M., Polineni, D., Patterson, G. A., Schwendener, R. A., Allard, J. D., Peltz, G. & 1 others, Holtzman, M. J., Jun 2008, In : Nature Medicine. 14, 6, p. 633-640 8 p.

Research output: Contribution to journalArticle

Pulmonary diseases
Virus Diseases
Innate Immunity
Respiratory Tract Infections
Lung Diseases
57 Citations (Scopus)

RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia

Tyner, J., Walters, D. K., Willis, S. G., Luttropp, M., Oost, J., Loriaux, M., Erickson, H., Corbin, A. S., O'Hare, T., Heinrich, M., Deininger, M. W. & Druker, B., Feb 15 2008, In : Blood. 111, 4, p. 2238-2245 8 p.

Research output: Contribution to journalArticle

RNA Interference
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Tyrosine
Screening
63 Citations (Scopus)

SGX393 inhibits the CML mutant Bcr-AblT315I and preempts in vitro resistance when combined with nilotinib or dasatinib

O'Hare, T., Eide, C. A., Tyner, J., Corbin, A. S., Wong, M. J., Buchanan, S., Holme, K., Jessen, K. A., Tang, C., Lewis, H. A., Romero, R. D., Burley, S. K. & Deininger, M. W., Apr 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5507-5512 6 p.

Research output: Contribution to journalArticle

Phosphotransferases
Leukemia
bcr-abl Fusion Proteins
Cell Line
Salvage Therapy
2007
30 Citations (Scopus)

A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia

Gu, T. L., Mercher, T., Tyner, J., Goss, V. L., Walters, D. K., Cornejo, M. G., Reeves, C., Popova, L., Lee, K., Heinrich, M., Rush, J., Daibata, M., Miyoshi, I., Gilliland, D. G., Druker, B. & Polakiewicz, R. D., Jul 1 2007, In : Blood. 110, 1, p. 323-333 11 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Leukemia, Megakaryoblastic, Acute
Macrophage Colony-Stimulating Factor
Fusion reactions
RNA
2006
243 Citations (Scopus)

Activating alleles of JAK3 in acute megakaryoblastic leukemia

Walters, D. K., Mercher, T., Gu, T. L., O'Hare, T., Tyner, J., Loriaux, M., Goss, V. L., Lee, K. A., Eide, C. A., Wong, M. J., Stoffregen, E. P., McGreevey, L., Nardone, J., Moore, S. A., Crispino, J., Boggon, T. J., Heinrich, M., Deininger, M. W., Polakiewicz, R. D., Gilliland, D. G. & 1 others, Druker, B., Jul 2006, In : Cancer Cell. 10, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

Leukemia, Megakaryoblastic, Acute
Alleles
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Mutation
176 Citations (Scopus)

Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals

Tyner, J., Kim, E. Y., Ide, K., Pelletier, M. R., Roswit, W. T., Morton, J. D., Battaile, J. T., Patel, A. C., Patterson, G. A., Castro, M., Spoor, M. S., You, Y., Brody, S. L. & Holtzman, M. J., Feb 1 2006, In : Journal of Clinical Investigation. 116, 2, p. 309-321 13 p.

Research output: Contribution to journalArticle

Goblet Cells
Interleukin-13
Metaplasia
Hyperplasia
Genetic Predisposition to Disease
29 Citations (Scopus)

FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248)

Schittenhelm, M. M., Yee, K., Tyner, J., McGreevey, L., Haley, A. D., Town, A., Griffith, D. J., Bainbridge, T., Braziel, R., O'Farrell, A. M., Cherrington, J. M. & Heinrich, M., Nov 2006, In : Leukemia. 20, 11, p. 2008-2014 7 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Phosphotransferases
Mutation
Codon
sunitinib
2005
31 Citations (Scopus)

Acute and chronic airway responses to viral infection: Implications for asthma and chronic obstructive pulmonary disease

Holtzman, M. J., Tyner, J., Kim, E. Y., Lo, M. S., Patel, A. C., Shornick, L. P., Agapov, E. & Zhang, Y., 2005, In : Proceedings of the American Thoracic Society. 2, 2, p. 132-140 9 p.

Research output: Contribution to journalArticle

Virus Diseases
Chronic Obstructive Pulmonary Disease
Antiviral Agents
Asthma
Viral Bronchiolitis
189 Citations (Scopus)

CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection

Tyner, J., Uchida, O., Kajiwara, N., Kim, E. Y., Patel, A. C., O'Sullivan, M. P., Walter, M. J., Schwendener, R. A., Cook, D. N., Danoff, T. M. & Holtzman, M. J., Nov 2005, In : Nature Medicine. 11, 11, p. 1180-1187 8 p.

Research output: Contribution to journalArticle

Macrophages
Virus Diseases
Viruses
Chemokines
Paramyxoviridae Infections

Defining and adjusting divergent host responses to viral infection

Holtzman, M. J., Kim, E. Y., Lo, M. S., Tyner, J., Shornick, L. P., Sumino, K. C. & Zhang, Y., 2005, In : Immunologic Research. 32, 1-3, p. 123-141 19 p.

Research output: Contribution to journalArticle

Virus Diseases
Antiviral Agents
Phenotype
Asthma
Infection
2004
9 Citations (Scopus)

"Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease

Holtzman, M. J., Shornick, L. P., Grayson, M. H., Kim, E. Y., Tyner, J., Patel, A. C., Agapov, E. & Zhang, Y., Nov 2004, In : Pediatric Infectious Disease Journal. 23, 11 SUPPL.

Research output: Contribution to journalArticle

Chronic Disease
Asthma
Antiviral Agents
Immune System
Infection
2003
24 Citations (Scopus)

Apoptosis in the airways: Another balancing act in the epithelial program

O'Sullivan, M. P., Tyner, J. & Holtzman, M. J., Jul 1 2003, In : American Journal of Respiratory Cell and Molecular Biology. 29, 1, p. 3-7 5 p.

Research output: Contribution to journalArticle

Respiratory system
Signal transduction
Pulmonary diseases
Apoptosis
Epithelial Cells