Jeffrey Tyner

Associate Professor

  • 5754 Citations
  • 36 h-Index
20022019
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Research Output 2002 2019

2019
11 Citations (Scopus)

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. & Tyner, J., Dec 1 2019, In : Nature Communications. 10, 1, 244.

Research output: Contribution to journalArticle

leukemias
mutations
Acute Myeloid Leukemia
Mutation
inhibitors
1 Citation (Scopus)

Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants

Eide, C. A., Zabriskie, M. S., Savage Stevens, S. L., Antelope, O., Vellore, N. A., Than, H., Schultz, A. R., Clair, P., Bowler, A. D., Pomicter, A. D., Yan, D., Senina, A. V., Qiang, W., Kelley, T. W., Szankasi, P., Heinrich, M. C., Tyner, J. W., Rea, D., Cayuela, J. M., Kim, D. W. & 4 others, Tognon, C. E., O'Hare, T., Druker, B. J. & Deininger, M. W., Oct 14 2019, In : Cancer Cell. 36, 4, p. 431-443.e5

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Adenosine Triphosphate
ponatinib
5 Citations (Scopus)

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E., Kaempf, A., Mori, M. T., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. & Tyner, J., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Acute Myeloid Leukemia
Macrophage Colony-Stimulating Factor
Cytokines
Cells

Erratum: Correction: FGF2-FGFR1 signaling regulates release of leukemia-protective exosomes from bone marrow stromal cells (eLife (2019) 8 PII: e47174)

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribeiro, R., Viola, S. K., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Mar 29 2019, In : eLife. 8

Research output: Contribution to journalComment/debate

Open Access
Exosomes
Fibroblast Growth Factor 2
Mesenchymal Stromal Cells
Medicine
Bone
3 Citations (Scopus)

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribiero, R., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Feb 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Exosomes
Fibroblast Growth Factor 2
Mesenchymal Stromal Cells
Protein-Tyrosine Kinases
Bone

Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma

Choonoo, G., Blucher, A. S., Higgins, S., Boardman, M., Jeng, S., Zheng, C., Jacobs, J., Anderson, A., Chamberlin, S., Evans, N., Vigoda, M., Cordier, B., Tyner, J. W., Kulesz-Martin, M., McWeeney, S. K. & Laderas, T., Jan 1 2019, In : PloS one. 14, 10, e0223639.

Research output: Contribution to journalArticle

Open Access
squamous cell carcinoma
Drug Delivery Systems
neck
drugs
neoplasms

Insights on mechanisms of clonal evolution in chronic neutrophilic leukemia on ruxolitinib therapy

Stoner, R. C., Press, R. D., Maxson, J. E., Tyner, J. W. & Dao, K. H. T., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Predicting response to BET inhibitors using computational modeling: A BEAT AML project study

Drusbosky, L. M., Vidva, R., Gera, S., Lakshminarayana, A. V., Shyamasundar, V. P., Agrawal, A. K., Talawdekar, A., Abbasi, T., Vali, S., Tognon, C. E., Kurtz, S. E., Tyner, J., McWeeney, S., Druker, B. & Cogle, C. R., Feb 1 2019, In : Leukemia Research. 77, p. 42-50 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Genomics
Computational Biology
MAP Kinase Signaling System
Chromosome Aberrations
1 Citation (Scopus)

Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinations

Lim, S. L., Damnernsawad, A., Shyamsunder, P., Chng, W. J., Han, B. C., Xu, L., Pan, J., Pravin, D. P., Alkan, S., Tyner, J. & Koeffler, H. P., Jun 1 2019, In : Haematologica. 104, 6, p. 1209-1220 12 p.

Research output: Contribution to journalArticle

Drug Combinations
Multiple Myeloma
Proteolysis
Biomarkers
Therapeutics
1 Citation (Scopus)

Replication timing alterations in leukemia affect clinically relevant chromosome domains

Rivera-Mulia, J. C., Sasaki, T., Trevilla-Garcia, C., Nakamichi, N., Knapp, D. J. H. F., Hammond, C. A., Chang, B. H., Tyner, J. W., Devidas, M., Zimmerman, J., Klein, K. N., Somasundaram, V., Druker, B. J., Gruber, T. A., Koren, A., Eaves, C. J. & Gilbert, D. M., Nov 12 2019, In : Blood Advances. 3, 21, p. 3201-3213 13 p.

Research output: Contribution to journalArticle

Open Access
B-Lymphoid Precursor Cells
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Chromosomes
Cell Differentiation

SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells

Sun, Q. Y., Ding, L. W., Johnson, K., Zhou, S., Tyner, J., Yang, H., Doan, N. B., Said, J. W., Xiao, J. F., Loh, X. Y., Ran, X. B., Venkatachalam, N., Lao, Z., Chen, Y., Xu, L., Fan, L. F., Chien, W., Lin, D. C. & Koeffler, H. P., Aug 22 2019, In : Oncogene. 38, 34, p. 6196-6210 15 p.

Research output: Contribution to journalArticle

Apoptosis
Lung Neoplasms
Neoplasms
Apoptosis Regulatory Proteins
Proteasome Inhibitors

Targeting mitochondria in cancer therapy could provide a basis for the selective anticancer activity

Rozanov, D., Cheltsov, A., Nilsen, A., Boniface, C., Forquer, I., Korkola, J., Gray, J., Tyner, J., Tognon, C. E., Mills, G. & Spellman, P., Mar 1 2019, In : PloS one. 14, 3, e0205623.

Research output: Contribution to journalArticle

Open Access
Mitochondria
Assays
mitochondria
therapeutics
neoplasms
7 Citations (Scopus)

The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells

Nechiporuk, T., Kurtz, S. E., Nikolova, O., Liu, T., Jones, C. L., D’alessandro, A., Culp-Hill, R., D’almeida, A., Joshi, S. K., Rosenberg, M., Tognon, C. E., Danilov, A., Druker, B., Chang, B., McWeeney, S. & Tyner, J., Jul 1 2019, In : Cancer discovery. 9, 7, p. 910-925 16 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Gene Silencing
Drug Combinations
Drug Resistance

What do functional genomics tell us about pathogenesis of AML?

Tyner, J. W., Bottomly, D., Wilmot, B. & McWeeney, S., Jan 1 2019, (Accepted/In press) In : Best Practice and Research: Clinical Haematology. 101101.

Research output: Contribution to journalReview article

Genomics
Acute Myeloid Leukemia
Tumors
Molecular Biology
Pharmaceutical Preparations
2018
3 Citations (Scopus)

A novel AGGF1-PDGFRβ fusion in pediatric T-cell acute lymphoblastic leukemia

Zabriskie, M. S., Antelope, O., Verma, A. R., Draper, L. R., Eide, C. A., Pomicter, A. D., Tran, T. H., Druker, B., Tyner, J., Miles, R. R., Graham, J. M., Hwang, J. Y., Varley, K. E., Toydemir, R. M., Deininger, M. W., Raetz, E. A. & O’Hare, T., Jan 31 2018, In : Haematologica. 103, 2, p. e87-e91

Research output: Contribution to journalComment/debate

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics
5 Citations (Scopus)

ARID1A and CEBPα cooperatively inhibit UCA1 transcription in breast cancer

Guo, X., Zhang, Y., Mayakonda, A., Madan, V., Ding, L. W., Lin, L. H., Zia, S., Gery, S., Tyner, J., Zhou, W., Yin, D., Lin, D. C. & Koeffler, H. P., Jul 6 2018, (Accepted/In press) In : Oncogene. p. 1-13 13 p.

Research output: Contribution to journalArticle

Histone Code
Cell Proliferation
Long Noncoding RNA
Breast Neoplasms
Mutation

Automated decision tree to evaluate genetic abnormalities when determining prognostic risk in acute myeloid leukemia

Watanabe-Smith, K., Druker, B., Tyner, J. & Edwards, D. K., Jul 31 2018, In : Haematologica. 103, 8, p. e351-e355

Research output: Contribution to journalLetter

Decision Trees
Acute Myeloid Leukemia
14 Citations (Scopus)

Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

Nair, A., Chung, H. C., Sun, T., Tyagi, S., Dobrolecki, L. E., Dominguez-Vidana, R., Kurley, S. J., Orellana, M., Renwick, A., Henke, D. M., Katsonis, P., Schmitt, E., Chan, D. W., Li, H., Mao, S., Petrovic, I., Creighton, C. J., Gutierrez, C., Dubrulle, J., Stossi, F. & 17 others, Tyner, J., Lichtarge, O., Lin, C. Y., Zhang, B., Scott, K. L., Hilsenbeck, S. G., Sun, J., Yu, X., Osborne, C. K., Schiff, R., Christensen, J. G., Shields, D. J., Rimawi, M. F., Ellis, M. J., Shaw, C. A., Lewis, M. T. & Westbrook, T. F., May 1 2018, In : Nature Medicine. 24, 4, p. 505-511 7 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Receptor Protein-Tyrosine Kinases
Tumors
Therapeutics
Neoplasms
1 Citation (Scopus)

Disparate effects of Shb gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia

Jamalpour, M., Li, X., Gustafsson, K., Tyner, J. & Welsh, M., Apr 1 2018, In : Tumor Biology. 40, 4

Research output: Contribution to journalArticle

Deficiency Diseases
T-Cell Leukemia
Myeloid Cells
Leukemia
B-Lymphocytes

Dual inhibition of JAK1/2 kinases and BCL2: a promising therapeutic strategy for acute myeloid leukemia

Kurtz, S. E., Eide, C. A., Kaempf, A., Mori, M. T., Tognon, C. E., Borate, U., Druker, B. & Tyner, J., Sep 1 2018, In : Leukemia. 32, 9, p. 2025-2028 4 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Phosphotransferases
Therapeutics
60 Citations (Scopus)

Functional genomic landscape of acute myeloid leukaemia

Tyner, J., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K-H., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M. T., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. & Druker, B., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
RNA Sequence Analysis
Pharmaceutical Preparations
Exome
Gene Regulatory Networks
4 Citations (Scopus)

Gain-of-function mutations in granulocyte colony–stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation

Zhang, H., Coblentz, C., Watanabe-Smith, K., Means, S., Means, J., Maxson, J. & Tyner, J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 19, p. 7387-7396 10 p.

Research output: Contribution to journalArticle

Granulocytes
Chemical activation
Mutation
Substitution reactions
Dimerization
1 Citation (Scopus)

Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models

Ouyang, X., Barling, A., Lesch, A., Tyner, J., Choonoo, G., Zheng, C., Jeng, S., West, T. M., Clayburgh, D., Courtneidge, S., McWeeney, S. & Kulesz-Martin, M., Oct 3 2018, In : Cancer Biology and Therapy. 19, 10, p. 921-933 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Small Interfering RNA
anaplastic lymphoma kinase
Carcinoma, squamous cell of head and neck
Neoplasms
1 Citation (Scopus)

LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma

Klug, L. R., Bannon, A. E., Javidi-Sharifi, N., Town, A., Fleming, W., VanSlyke, J. K., Musil, L., Fletcher, J. A., Tyner, J. & Heinrich, M., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Lemur
Gastrointestinal Stromal Tumors
Protein-Tyrosine Kinases
Melanoma
Small Interfering RNA

Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL

Chow, M., Gao, L., MacManiman, J. D., Bicocca, V. T., Chang, B., Alumkal, J. & Tyner, J., May 30 2018, (Accepted/In press) In : Oncogene. p. 1-12 12 p.

Research output: Contribution to journalArticle

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Protein Transport
B-Lymphoid Precursor Cells
Maintenance
Proteasome Endopeptidase Complex

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

Jenkins, C., Luty, S. B., Maxson, J., Eide, C. A., Abel, M. L., Togiai, C., Nemecek, E., Bottomly, D., McWeeney, S., Wilmot, B., Loriaux, M., Chang, B. & Tyner, J., Jul 17 2018, In : Science Signaling. 11, 539, eaao5617.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Leukemia
Acute Myeloid Leukemia
Myeloid Cells
Mitogen-Activated Protein Kinases
6 Citations (Scopus)

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A., Lee, P., Chantry, D., McWeeney, S., Druker, B., Tyner, J., Spurgeon, S. & Loriaux, M., May 15 2018, In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
B-Cell Chronic Lymphocytic Leukemia
Antineoplastic Agents
Monocytes
2 Citations (Scopus)

Two myeloid leukemia cases with rare FLT3 fusions

Zhang, H., Paliga, A., Hobbs, E., Moore, S., Olson, S., Long, N., Dao, K-H. & Tyner, J., Dec 1 2018, In : Cold Spring Harbor molecular case studies. 4, 6

Research output: Contribution to journalArticle

Myeloid Leukemia
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Bone Marrow
Leukemia, Myelomonocytic, Chronic
Myeloproliferative Disorders
2017
16 Citations (Scopus)

BCL6 promotes glioma and serves as a therapeutic target

Xu, L., Chen, Y., Dutra-Clarke, M., Mayakonda, A., Hazawa, M., Savinoff, S. E., Doan, N., Said, J. W., Yong, W. H., Watkins, A., Yang, H., Ding, L. W., Jiang, Y. Y., Tyner, J., Ching, J., Kovalik, J. P., Madan, V., Chan, S. L., Müschen, M., Breunig, J. J. & 3 others, Lin, D. C., Koeffler, H. P. & Cavenee, W. K., 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 15

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Ribosomal Protein S6
Ribosomal Protein S6 Kinases
Mitogen-Activated Protein Kinase Kinases
8 Citations (Scopus)

Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations

Zhang, H., Reister Schultz, A., Luty, S., Rofelty, A., Su, Y., Means, S., Bottomly, D., Wilmot, B., McWeeney, S. & Tyner, J., Dec 1 2017, In : Leukemia. 31, 12, p. 2752-2760 9 p.

Research output: Contribution to journalArticle

Missense Mutation
Mutation
High-Throughput Nucleotide Sequencing
Ubiquitination
Leukemia
8 Citations (Scopus)

Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia

Bandyopadhyay, S., Li, J., Traer, E., Tyner, J., Zhou, A., Oh, S. T. & Cheng, J. X., Jul 1 2017, In : PLoS One. 12, 7, e0179558.

Research output: Contribution to journalArticle

Esterification
esterification
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
leukemia
Cholesterol
13 Citations (Scopus)

CPX-351 exhibits potent and direct ex vivo cytotoxicity against AML blasts with enhanced efficacy for cells harboring the FLT3-ITD mutation

Gordon, M. J., Tardi, P., Loriaux, M., Spurgeon, S., Traer, E., Kovacsovics, T., Mayer, L. D. & Tyner, J., Feb 1 2017, In : Leukemia Research. 53, p. 39-49 11 p.

Research output: Contribution to journalArticle

Mutation
B-Cell Chronic Lymphocytic Leukemia
Inhibitory Concentration 50
Daunorubicin
Myelodysplastic Syndromes
1 Citation (Scopus)

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, K., Hjorth-Hansen, H., Druker, B., Enserink, J. M., Tyner, J., Mustjoki, S. & Porkka, K., 2017, In : Oncotarget. 8, 14, p. 22606-22615 10 p.

Research output: Contribution to journalArticle

Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Leukemia
Stem Cells

DNA distress creates lethal opportunity in MPN

Tyner, J., Dec 28 2017, In : Blood. 130, 26, p. 2814-2816 3 p.

Research output: Contribution to journalReview article

Stem Cells
Double-Stranded DNA Breaks
DNA
Stem cells
DNA Repair
6 Citations (Scopus)

EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT

Merchant, A. A., Jorapur, A., McManus, A., Liu, R., Krasnoperov, V., Chaudhry, P., Singh, M., Harton, L., Agajanian, M., Kim, M., Triche, T. J., Druker, B. J., Tyner, J. W. & Gill, P. S., Sep 12 2017, In : Blood Advances. 1, 20, p. 1635-1644 10 p.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia
Cell Survival
Leukemia
Eph Family Receptors
Phosphatidylinositol 3-Kinase

Evaluation of safety in biomarker driven multiple agent phase IB trial

Mori, M. T., Daffé, R., Park, B. & Tyner, J., Oct 3 2017, Frontiers of Biostatistical Methods and Applications in Clinical Oncology. Springer Singapore, p. 53-64 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biomarkers
Inhibitor
Phosphotransferases
Safety
Evaluation
38 Citations (Scopus)

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Frismantas, V., Dobay, M. P., Rinaldi, A., Tchinda, J., Dunn, S. H., Kunz, J., Richter-Pechanska, P., Marovca, B., Pail, O., Jenni, S., Diaz-Flores, E., Chang, B., Brown, T. J., Collins, R. H., Uhrig, S., Balasubramanian, G. P., Bandapalli, O. R., Higi, S., Eugster, S., Voegeli, P. & 17 others, Delorenzi, M., Cario, G., Loh, M. L., Schrappe, M., Stanulla, M., Kulozik, A. E., Muckenthaler, M. U., Saha, V., Irving, J. A., Meisel, R., Radimerski, T., Von Stackelberg, A., Eckert, C., Tyner, J., Horvath, P., Bornhauser, B. C. & Bourquin, J. P., Mar 16 2017, In : Blood. 129, 11, p. e26-e37

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Pharmaceutical Preparations
T-cells
19 Citations (Scopus)

Genomics of chronic neutrophilic leukemia

Maxson, J. & Tyner, J., Feb 9 2017, In : Blood. 129, 6, p. 715-722 8 p.

Research output: Contribution to journalReview article

Leukemia, Neutrophilic, Chronic
Colony-Stimulating Factors
Genomics
Mutation
Colony-Stimulating Factor Receptors
19 Citations (Scopus)

Identification of a novel SYK/c-MYC/MALAT1 signaling pathway and its potential therapeutic value in Ewing sarcoma

Sun, H., Lin, D. C., Cao, Q., Pang, B., Gae, D. D., Lee, V. K. M., Lim, H. J., Doan, N., Said, J. W., Gery, S., Chow, M., Mayakonda, A., Forscher, C., Tyner, J. & Koeffler, H. P., Aug 1 2017, In : Clinical Cancer Research. 23, 15, p. 4376-4387 12 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Therapeutics
Syk Kinase
Long Noncoding RNA
Small Molecule Libraries
38 Citations (Scopus)

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

Carey, A., Edwards, D. K., Eide, C. A., Newell, L., Traer, E., Medeiros, B. C., Pollyea, D. A., Deininger, M. W., Collins, R. H., Tyner, J., Druker, B., Bagby, G. C., McWeeney, S. & Agarwal, A., Mar 28 2017, In : Cell Reports. 18, 13, p. 3204-3218 15 p.

Research output: Contribution to journalArticle

Interleukin-1
Acute Myeloid Leukemia
Disease Progression
Screening
Interleukin-1 Receptors
Adult T Cell Leukemia Lymphoma
Therapeutics
2 Citations (Scopus)

Kinase Inhibitor Screening in Myeloid Malignancies

Tyner, J., Aug 1 2017, In : Hematology/Oncology Clinics of North America. 31, 4, p. 693-704 12 p.

Research output: Contribution to journalReview article

Phosphotransferases
Neoplasms
Point Mutation
Pharmaceutical Preparations
Therapeutics
2 Citations (Scopus)

Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets

Kanojia, D., Garg, M., Martinez, J., Anand, M. T., Luty, S. B., Doan, N. B., Said, J. W., Forscher, C., Tyner, J. & Koeffler, H. P., Nov 13 2017, In : Journal of Hematology and Oncology. 10, 1, 173.

Research output: Contribution to journalArticle

Liposarcoma
Preclinical Drug Evaluations
RNA Interference
Phosphotransferases
Protein-Tyrosine Kinases
15 Citations (Scopus)

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade

Lue, H. W., Podolak, J., Kolahi, K., Cheng, L., Rao, S., Garg, D., Xue, C. H., Rantala, J. K., Tyner, J., Thornburg, K., Martinez-Acevedo, A., Liu, J-J., Amling, C., Truillet, C., Louie, S. M., Anderson, K. E., Evans, M. J., O’Donnell, V. B., Nomura, D. K., Drake, J. M. & 2 others, Ritz, A. & Thomas, G., Oct 15 2017, In : Genes and Development. 31, 20, p. 2067-2084 18 p.

Research output: Contribution to journalArticle

Cell Survival
Autophagy
Phospholipases A2
Oxidative Phosphorylation
Neoplasms
32 Citations (Scopus)

Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies

Kurtz, S. E., Eide, C. A., Kaempf, A., Khanna, V., Savage, S. L., Rofelty, A., English, I., Ho, H., Pandya, R., Bolosky, W. J., Poon, H., Deininger, M. W., Collins, R., Swords, R. T., Watts, J., Pollyea, D. A., Medeiros, B. C., Traer, E., Tognon, C. E., Mori, M. T. & 2 others, Druker, B. & Tyner, J., Sep 5 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 36, p. E7554-E7563

Research output: Contribution to journalArticle

Hematologic Neoplasms
Drug Combinations
Acute Myeloid Leukemia
B-Cell Chronic Lymphocytic Leukemia
Cytogenetics
4 Citations (Scopus)

PlGF enhances TLR-dependent inflammatory responses in human mononuclear phagocytes

Newell, L., Holtan, S. G., Yates, J. E., Pereira, L., Tyner, J., Burd, I. & Bagby, G. C., 2017, (Accepted/In press) In : American Journal of Reproductive Immunology.

Research output: Contribution to journalArticle

Toll-Like Receptors
Phagocytes
Intercellular Signaling Peptides and Proteins
I-kappa B Kinase
Toll-Like Receptor 8
5 Citations (Scopus)

Recent Progress in Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia

Dao, K-H., Tyner, J. & Gotlib, J., Oct 6 2017, (Accepted/In press) In : Current Hematologic Malignancy Reports. p. 1-10 10 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Leukemia, Neutrophilic, Chronic
Therapeutics
Hyperplasia
Bone Marrow
3 Citations (Scopus)

Recurrent cyclin D2 mutations in myeloid neoplasms

Khanna, V., Eide, C. A., Tognon, C. E., Maxson, J., Wilmot, B., Bottomly, D., McWeeney, S., Edwards, V. D. K., Druker, B. & Tyner, J., Sep 1 2017, In : Leukemia. 31, 9, p. 2005-2008 4 p.

Research output: Contribution to journalLetter

8 Citations (Scopus)

Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer

Weber, H., Valbuena, J. R., Barbhuiya, M. A., Stein, S., Kunkel, H., García, P., Bizama, C., Riquelme, I., Espinoza, J. A., Kurtz, S. E., Tyner, J., Calderon, J. F., Corvalán, A. H., Grez, M., Pandey, A., Leal-Rojas, P. & Roa, J. C., 2017, In : Oncotarget. 8, 16, p. 26169-26184 16 p.

Research output: Contribution to journalArticle

tanespimycin
Gallbladder Neoplasms
Neoplasms
Therapeutics
G2 Phase Cell Cycle Checkpoints
15 Citations (Scopus)

Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia

Sasaki, T., Rivera-Mulia, J. C., Vera, D., Zimmerman, J., Das, S., Padget, M., Nakamichi, N., Chang, B., Tyner, J., Druker, B., Weng, A. P., Civin, C. I., Eaves, C. J. & Gilbert, D. M., Jul 1 2017, In : Experimental Hematology. 51, p. 71-82.e3

Research output: Contribution to journalArticle

DNA Replication Timing
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Heterografts
Lymphocytes
Serial Passage