Research Output 1997 2019

13 Citations (Scopus)

Activation of the G-CSF and Flt-3 receptors protects hematopoietic stem cells from lethal irradiation

Streeter, P., Dudley, L. Z. & Fleming, W., Nov 2003, In : Experimental Hematology. 31, 11, p. 1119-1125 7 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cells
Granulocyte Colony-Stimulating Factor Receptors
Cytokines
Hematopoiesis
12 Citations (Scopus)

Administration of daniplestim and granulocyte colony-stimulating factor for the mobilization of hematopoietic progenitor cells in nonhuman primates

Fleming, W., Lankford-Turner, P., Turner, C. W., Wong, J., Strobert, E. & McKearn, J. P., 1999, In : Biology of Blood and Marrow Transplantation. 5, 1, p. 8-14 7 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cells
Primates
Stem Cells
Interleukin-3 Receptors
37 Citations (Scopus)

Adult blood vessels restore host hematopoiesis following lethal irradiation

Montfort, M. J., Olivares, C. R., Mulcahy, J. M. & Fleming, W., 2002, In : Experimental Hematology. 30, 8, p. 950-956 7 p.

Research output: Contribution to journalArticle

Hematopoiesis
Blood Vessels
Stem Cells
Transplantation
Tunica Intima
17 Citations (Scopus)

Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop

Li, K., Rodosthenous, R. S., Kashanchi, F., Gingeras, T., Gould, S. J., Kuo, L. S., Kurre, P., Lee, H., Leonard, J. N., Liu, H., Lombo, T. B., Momma, S., Nolan, J. P., Ochocinska, M. J., Pegtel, D. M., Sadovsky, Y., Sánchez-Madrid, F., Valdes, K. M., Vickers, K. C., Weaver, A. M. & 5 others, Witwer, K. W., Zeng, Y., Das, S., Raffai, R. L. & Howcroft, T. K., Apr 5 2018, In : JCI insight. 3, 7

Research output: Contribution to journalReview article

Open Access
RNA
Education
Research
RNA Transport
Transducers
17 Citations (Scopus)

Alteration of epithelial cell transferrin-iron homeostasis by Neisseria meningitidis and Neisseria gonorrhoeae

Bonnah, R., Lee, S. W., Vasquez, B. L., Enns, C. & So, M., 2000, In : Cellular Microbiology. 2, 3, p. 207-218 12 p.

Research output: Contribution to journalArticle

Neisseria meningitidis
Neisseria gonorrhoeae
Transferrin
Homeostasis
Iron
23 Citations (Scopus)
Neoplasm Drug Resistance
Exosomes
Protein Kinase Inhibitors
MicroRNAs
Mesenchymal Stromal Cells
43 Citations (Scopus)

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

Hornick, N. I., Doron, B., Abdelhamed, S., Huan, J., Harrington, C. C., Shen, R., Cambronne, X., Verghese, S. C. & Kurre, P., Sep 6 2016, In : Science Signaling. 9, 444, ra88.

Research output: Contribution to journalArticle

Exosomes
Hematopoiesis
MicroRNAs
Acute Myeloid Leukemia
Hematopoietic Stem Cells
2 Citations (Scopus)

Anchored lentiviral vector episomes for stem cell gene therapy in fanconi anemia

Verghese, S. C. & Kurre, P., Oct 1 2016, In : Current Gene Therapy. 16, 5, p. 329-337 9 p.

Research output: Contribution to journalReview article

Fanconi Anemia
Cell- and Tissue-Based Therapy
Genetic Therapy
Plasmids
Stem Cells
75 Citations (Scopus)

A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection

Umashankar, M., Petrucelli, A., Cicchini, L., Caposio, P., Kreklywich, C. N., Rak, M., Bughio, F., Goldman, D., Hamlin, K. L., Nelson, J., Fleming, W., Streblow, D. & Goodrum, F., Dec 2011, In : PLoS Pathogens. 7, 12, e1002444.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Cytomegalovirus
Viruses
Fibroblasts
Infection
27 Citations (Scopus)

A novel regulatory pathway for autoimmune disease: Binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance

Vandenbark, A., Meza-Romero, R., Benedek, G., Andrew, S., Huan, J., Chou, Y. K., Buenafe, A. C., Dahan, R., Reiter, Y., Mooney, J. L., Offner, H. & Burrows, G. G., Feb 2013, In : Journal of Autoimmunity. 40, 1, p. 96-110 15 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Monocytes
Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
Macrophage Migration-Inhibitory Factors
69 Citations (Scopus)

Anthracyclines induce DNA damage response-mediated protection against severe sepsis

Figueiredo, N., Chora, A., Raquel, H., Pejanovic, N., Pereira, P., Hartleben, B., Neves-Costa, A., Moita, C., Pedroso, D., Pinto, A., Marques, S., Faridi, H., Costa, P., Gozzelino, R., Zhao, J. L., Soares, M. P., Gama-Carvalho, M., Martinez, J., Zhang, Q-S., Döring, G. & 8 others, Grompe, M., Simas, J. P., Huber, T. B., Baltimore, D., Gupta, V., Green, D. R., Ferreira, J. A. & Moita, L. F., Nov 14 2013, In : Immunity. 39, 5, p. 874-884 11 p.

Research output: Contribution to journalArticle

Anthracyclines
DNA Damage
Sepsis
Ataxia Telangiectasia
Autophagy
37 Citations (Scopus)

Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds

Kampa, K. M., Acoba, J. D., Chen, D., Gay, J., Lee, H., Beemer, K., Padiernos, E., Boonmark, N., Zhu, Z., Fan, A. C., Bailey, A. S., Fleming, W., Corless, C., Felsher, D. W., Naumovski, L. & Lopez, C., Mar 17 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4390-4395 6 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
Proteins
Thymocytes
Gastrin-Secreting Cells
40 Citations (Scopus)
Autoimmune Experimental Encephalomyelitis
Interleukin-17
T-Cell Antigen Receptor
Multiple Sclerosis
Cell Movement
1 Citation (Scopus)

Avoiding lentiviral transduction culture induced MSC senescence: Letter to the editor

Pan, Y. W. & Kurre, P., Jun 2009, In : Journal of Cellular and Molecular Medicine. 13, 6, p. 1186-1187 2 p.

Research output: Contribution to journalArticle

Genetic Transduction
Lentivirus
Cell Aging
Telomerase
Mesenchymal Stromal Cells
22 Citations (Scopus)

Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis

Sinha, S., Miller, L., Subramanian, S., McCarty, O., Proctor, T., Meza-Romero, R., Huan, J., Burrows, G. G., Vandenbark, A. & Offner, H., Aug 2010, In : Journal of Neuroimmunology. 225, 1-2, p. 52-61 10 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Antigen-Presenting Cells
T-Cell Antigen Receptor
Up-Regulation
Ligands
76 Citations (Scopus)

BMP4 regulates the hematopoietic stem cell niche

Goldman, D., Bailey, A. S., Pfaffle, D. L., Al Masri, A., Christian, J. L. & Fleming, W., Nov 12 2009, In : Blood. 114, 20, p. 4393-4401 9 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 4
Stem Cell Niche
Hematopoietic Stem Cells
Stem cells
Hematopoiesis
199 Citations (Scopus)

Bone marrow-derived cells fuse with normal and transformed intestinal stem cells

Rizvi, A. Z., Swain, J. R., Davies, P., Bailey, A. S., Decker, A. D., Willenbring, H., Grompe, M., Fleming, W. & Wong, M., Apr 18 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 16, p. 6321-6325 5 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Stem Cells
Cell Fusion
Intestines
Regeneration
165 Citations (Scopus)

Bone marrow failure in fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells

Ceccaldi, R., Parmar, K., Mouly, E., Delord, M., Kim, J. M., Regairaz, M., Pla, M., Vasquez, N., Zhang, Q-S., Pondarre, C., Peffault De Latour, R., Gluckman, E., Cavazzana-Calvo, M., Leblanc, T., Larghero, J., Grompe, M., Socié, G., D'Andrea, A. D. & Soulier, J., Jul 6 2012, In : Cell Stem Cell. 11, 1, p. 36-49 14 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Hematopoietic Stem Cells
DNA Damage
Bone Marrow
DNA Repair-Deficiency Disorders
9 Citations (Scopus)

CD25 expression distinguishes functionally distinct alloreactive CD4+ CD134+ (OX40+) T-cell subsets in acute graft-versus-host disease

Streeter, P., Zhang, X., Tittle, T. V., Schön, C. N., Weinberg, A. D. & Maziarz, R., May 2004, In : Biology of Blood and Marrow Transplantation. 10, 5, p. 298-309 12 p.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Graft vs Host Disease
Isoantigens
Interleukin-2
T-Lymphocytes
8 Citations (Scopus)

Cell- Cell Transmission of VSV-G Pseudotyped Lentivector Particles

Skinner, A., Chakkaramakkil Verghese, S. & Kurre, P., Sep 10 2013, In : PLoS One. 8, 9, e74925.

Research output: Contribution to journalArticle

cells
Primate T-lymphotropic virus 1
Kinetics
Viruses
Human T-lymphotropic virus 1
16 Citations (Scopus)

Cellular microvesicle pathways can be targeted to transfer genetic information between non-immune cells

Skinner, A., O'Neil, S. L. & Kurre, P., Jul 13 2009, In : PLoS One. 4, 7, e6219.

Research output: Contribution to journalArticle

Genes
Transfer RNA
Genome
cells
transfer RNA

Characterization of dendritic cells generated in vivo by an E. coli derived chimeric dual receptor agonist

Kahn, L. E., Doshi, P., McGarity, K. L., Yu, M., Bono, C. P., Lie, W. R., Rankin, A. M., Smidt, M. L., Streeter, P., Klein, B. K., Welply, J. K. & Woulfe, S. L., Dec 1 2002, In : Medical Science Monitor. 8, 12

Research output: Contribution to journalArticle

Dendritic Cells
Escherichia coli
Spleen
Leukocytes
Granulocyte Colony-Stimulating Factor Receptors
45 Citations (Scopus)

Clinical scale expanded adult pluripotent stem cells prevent graft-versus-host disease

Kovacsovics-Bankowski, M., Streeter, P., Mauch, K. A., Frey, M. R., Raber, A., Hof, W. V. T., Deans, R. & Maziarz, R., 2009, In : Cellular Immunology. 255, 1-2, p. 55-60 6 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Adult Stem Cells
Graft vs Host Disease
Stem Cells
Multipotent Stem Cells
1 Citation (Scopus)

Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model

Zhang, Q-S., Deater, M., Phan, N., Marcogliese, A., Major, A., Guinan, E. C. & Grompe, M., Jan 1 2018, (Accepted/In press) In : Pediatric Blood and Cancer.

Research output: Contribution to journalArticle

Celecoxib
Fanconi Anemia
Neoplasms
Therapeutics
Pharmaceutical Preparations
7 Citations (Scopus)

Concise Review: Adaptation of the Bone Marrow Stroma in Hematopoietic Malignancies: Current Concepts and Models

Doron, B., Handu, M. & Kurre, P., Jan 1 2018, (Accepted/In press) In : Stem Cells.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Hematopoietic Stem Cells
Bone Marrow
Leukemia
Stem Cell Niche
61 Citations (Scopus)

Converging roads: Evidence for an adult hemangioblast

Bailey, A. S. & Fleming, W., Nov 2003, In : Experimental Hematology. 31, 11, p. 987-993 7 p.

Research output: Contribution to journalArticle

Hemangioblasts
Blood Vessels
Hematopoietic Stem Cells
Bone Marrow
Hematopoietic System
39 Citations (Scopus)

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Huan, J., Hornick, N. I., Goloviznina, N. A., Kamimae-Lanning, A. N., David, L., Wilmarth, P., Mori, M. T., Chevillet, J. R., Narla, A., Roberts, C., Loriaux, M., Chang, B. & Kurre, P., Jun 25 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Exosomes
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Bone Marrow
Exosome Multienzyme Ribonuclease Complex
15 Citations (Scopus)

Corepressor Rcor1 is essential for murine erythropoiesis

Yao, H., Goldman, D., Nechiporuk, T., Kawane, S., McWeeney, S., Tyner, J., Fan, G., Kerenyi, M. A., Orkin, S. H., Fleming, W. & Mandel, G., May 15 2014, In : Blood. 123, 20, p. 3175-3184 10 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Erythropoiesis
Genes
Erythroblasts
Colony-Stimulating Factor Receptors
2 Citations (Scopus)

Costs and consequences of immunosuppressive therapy in children with aplastic anemia

Shereck, E., Deyell, R. J. & Kurre, P., Jun 2011, In : Haematologica. 96, 6, p. 793-795 3 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Hematopoietic Stem Cell Transplantation
Homologous Transplantation
Immunosuppressive Agents
Immunosuppression
17 Citations (Scopus)

CXCR4 but not CXCR7 is mainly implicated in ocular leukocyte trafficking during ovalbumin-induced acute uveitis

Zhang, Z., Zhong, W., Hall, M. J., Kurre, P., Spencer, D., Skinner, A., O'Neill, S., Xia, Z. & Rosenbaum, J. J., Oct 2009, In : Experimental Eye Research. 89, 4, p. 522-531 10 p.

Research output: Contribution to journalArticle

Uveitis
Ovalbumin
Leukocytes
T-Lymphocytes
Chemokine Receptors
10 Citations (Scopus)

CXCR4 induction in hematopoietic progenitor cells from Fanca-/-, -c-/-, and -d2-/- mice

Skinner, A., O'Neill, S. L., Grompe, M. & Kurre, P., Mar 2008, In : Experimental Hematology. 36, 3, p. 273-282 10 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Hematopoietic Stem Cells
Stem Cells
Chimerism
Genotype
12 Citations (Scopus)
Semaphorin-3A
Heat-Shock Proteins
Autoantibodies
Chaperonin 60
Ocular Paraneoplastic Syndromes
37 Citations (Scopus)

Diagnosis and treatment of children with aplastic anemia

Kurre, P., Johnson, F. L. & Deeg, H. J., Oct 2005, In : Pediatric Blood and Cancer. 45, 6, p. 770-780 11 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Hematopoietic Stem Cell Transplantation
Immunosuppressive Agents
Tissue Donors
Therapeutics
15 Citations (Scopus)

Donor marker infidelity in transgenic hematopoietic stem cells

Anderson, D. A., Wu, Y., Jiang, S., Zhang, X., Streeter, P., Spangrude, G. J., Archer, D. R. & Fleming, W., May 2005, In : Stem Cells. 23, 5, p. 638-643 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem Cells
Myeloid Cells
Transgenes
Transgenic Mice
12 Citations (Scopus)

Double-negative T cells are non-ALPS-specific markers of immune dysregulation found in patients with aplastic anemia

Russell, T. B. & Kurre, P., Dec 2 2010, In : Blood. 116, 23, p. 5072-5073 2 p.

Research output: Contribution to journalArticle

Autoimmune Lymphoproliferative Syndrome
T-cells
Aplastic Anemia
T-Lymphocyte Subsets
Biomarkers
7 Citations (Scopus)

Ectodermally derived steel/stem cell factor functions non-cell autonomously during primitive erythropoiesis in Xenopus

Goldman, D., Berg, L. K., Heinrich, M. & Christian, J. L., Apr 15 2006, In : Blood. 107, 8, p. 3114-3121 8 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Erythropoiesis
Steel
Xenopus
Mesoderm

Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: A “U-shaped” relationship

Shi, M., Flores, B., Li, P., Gillings, N., McMillan, K. L., Ye, J., Huang, L. J. S., Sidhu, S. S., Zhong, Y. P., Grompe, M. T., Streeter, P., Moe, O. W. & Hu, M. C., Apr 1 2018, In : American Journal of Physiology - Renal Physiology. 314, 4, p. F501-F516

Research output: Contribution to journalArticle

Erythropoietin Receptors
Acute Kidney Injury
Fibrosis
Wounds and Injuries
Kidney
3 Citations (Scopus)

Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2−/− Hematopoietic Stem and Progenitor Cells

Yoon, Y. M., Storm, K. J., Kamimae-Lanning, A. N., Goloviznina, N. A. & Kurre, P., Nov 8 2016, In : Stem Cell Reports. 7, 5, p. 840-853 14 p.

Research output: Contribution to journalArticle

Fanconi Anemia Complementation Group Proteins
Hematopoietic Stem Cells
DNA Damage
DNA
Chemical activation
25 Citations (Scopus)

Endothelial cells mediate the regeneration of hematopoietic stem cells

Li, B., Bailey, A. S., Jiang, S., Liu, B., Goldman, D. & Fleming, W., Jan 2010, In : Stem Cell Research. 4, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Regeneration
Endothelial Cells
Transplantation
Adult Stem Cells
8 Citations (Scopus)

Endothelial cells mitigate DNA damage and promote the regeneration of hematopoietic stem cells after radiation injury

Zachman, D. K., Leon, R. P., Das, P., Goldman, D., Hamlin, K. L., Guha, C. & Fleming, W., 2013, In : Stem Cell Research. 11, 3, p. 1013-1021 9 p.

Research output: Contribution to journalArticle

Radiation Injuries
Hematopoietic Stem Cells
DNA Damage
Regeneration
Endothelial Cells
2 Citations (Scopus)

Endothelial cell-specific markers: Going . . . going . . . gone

Fleming, W., Aug 1 2005, In : Blood. 106, 3, p. 769 1 p.

Research output: Contribution to journalArticle

Endothelial cells
12 Citations (Scopus)

Entry kinetics and cell-cell transmission of surface-bound retroviral vector particles

O'Neill, L. S., Skinner, A., Woodward, J. A. & Kurre, P., May 2010, In : Journal of Gene Medicine. 12, 5, p. 463-476 14 p.

Research output: Contribution to journalArticle

Fibronectins
Extracellular Matrix
Lentivirus
Hematopoietic Stem Cells
Heparin
211 Citations (Scopus)

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

Bramswig, N. C., Everett, L. J., Schug, J., Dorrell, C., Liu, C., Luo, Y., Streeter, P., Naji, A., Grompe, M. & Kaestner, K. H., Mar 1 2013, In : Journal of Clinical Investigation. 123, 3, p. 1275-1284 10 p.

Research output: Contribution to journalArticle

Epigenomics
Islets of Langerhans
Glucagon
Histone Code
Glucagon-Secreting Cells
1 Citation (Scopus)
Toll-Like Receptors
Luciferases
Mesenchymal Stromal Cells
Cytokines
Assays

Erratum: Transcriptomes of the major human pancreatic cell types (Diabetologia DOI: 10.1007/s00125-011-2283-5)

Dorrell, C., Schug, J., Lin, C. F., Canaday, P. S., Fox, A. J., Smirnova, O., Bonnah, R., Streeter, P., Stoeckert, C. J., Kaestner, K. H. & Grompe, M., May 2013, In : Diabetologia. 56, 5, p. 1192 1 p.

Research output: Contribution to journalArticle

Transcriptome
10 Citations (Scopus)

Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model

Zhang, Q-S., Marquez-Loza, L., Sheehan, A. M., Watanabe-Smith, K., Eaton, L., Benedetti, E., Major, A., Schubert, K., Deater, M., Joseph, E. & Grompe, M., Apr 2014, In : Pediatric Blood and Cancer. 61, 4, p. 740-742 3 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Chemoprevention
Acetylcysteine
Antioxidants
Neoplasms
23 Citations (Scopus)

Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis

Bonnah, R., Muckenthaler, M. U., Carlson, H., Minana, B., Enns, C., Hentze, M. W. & So, M., May 2004, In : Cellular Microbiology. 6, 5, p. 473-484 12 p.

Research output: Contribution to journalArticle

Neisseria meningitidis
Transferrin Receptors
Iron
Genes
Epithelial Cells

Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche

Abdelhamed, S., Butler, J. T., Doron, B., Halse, A., Nemecek, E., Wilmarth, P., Marks, D., Chang, B., Horton, T. & Kurre, P., Jul 1 2019, In : EMBO Reports. 20, 7, e47546.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Acute Myeloid Leukemia
DNA
DNA Damage
11 Citations (Scopus)

Extracellular vesicles in the hematopoietic microenvironment

Butler, J. T., Abdelhamed, S. & Kurre, P., Feb 28 2018, In : Haematologica. 103, 3, p. 382-394 13 p.

Research output: Contribution to journalReview article

Hematopoietic Stem Cells
Bone Marrow
Hematopoiesis
Cues
Extracellular Vesicles
58 Citations (Scopus)

Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol

Zhang, Q-S., Marquez-Loza, L., Eaton, L., Duncan, A. W., Goldman, D., Anur, P., Watanabe-Smith, K., Rathbun, R. K., Fleming, W., Bagby, G. C. & Grompe, M., Dec 9 2010, In : Blood. 116, 24, p. 5140-5148 9 p.

Research output: Contribution to journalArticle

Bone
Bone Marrow
Cells
Fanconi Anemia
Defects