Research Output 1997 2019

2013
8 Citations (Scopus)

Endothelial cells mitigate DNA damage and promote the regeneration of hematopoietic stem cells after radiation injury

Zachman, D. K., Leon, R. P., Das, P., Goldman, D., Hamlin, K. L., Guha, C. & Fleming, W., 2013, In : Stem Cell Research. 11, 3, p. 1013-1021 9 p.

Research output: Contribution to journalArticle

Radiation Injuries
Hematopoietic Stem Cells
DNA Damage
Regeneration
Endothelial Cells
211 Citations (Scopus)

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

Bramswig, N. C., Everett, L. J., Schug, J., Dorrell, C., Liu, C., Luo, Y., Streeter, P., Naji, A., Grompe, M. & Kaestner, K. H., Mar 1 2013, In : Journal of Clinical Investigation. 123, 3, p. 1275-1284 10 p.

Research output: Contribution to journalArticle

Epigenomics
Islets of Langerhans
Glucagon
Histone Code
Glucagon-Secreting Cells

Erratum: Transcriptomes of the major human pancreatic cell types (Diabetologia DOI: 10.1007/s00125-011-2283-5)

Dorrell, C., Schug, J., Lin, C. F., Canaday, P. S., Fox, A. J., Smirnova, O., Bonnah, R., Streeter, P., Stoeckert, C. J., Kaestner, K. H. & Grompe, M., May 2013, In : Diabetologia. 56, 5, p. 1192 1 p.

Research output: Contribution to journalArticle

Transcriptome
6 Citations (Scopus)

Fancd2 and p21 function independently in maintaining the size of hematopoietic stem and progenitor cell pool in mice

Zhang, Q-S., Watanabe-Smith, K., Schubert, K., Major, A., Sheehan, A. M., Marquez-Loza, L., Newell, A. E. H., Benedetti, E., Joseph, E., Olson, S. & Grompe, M., Sep 2013, In : Stem Cell Research. 11, 2, p. 687-692 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Fanconi Anemia
Cell Cycle Proteins
Knockout Mice
Bone Marrow Cells
18 Citations (Scopus)

Fetal origins of hematopoietic failure in a murine model of Fanconi anemia.

Kamimae-Lanning, A. N., Goloviznina, N. A. & Kurre, P., Mar 14 2013, In : Blood. 121, 11, p. 2008-2012 5 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Hematopoietic Stem Cells
Liver
Bone
Hematopoiesis
1 Citation (Scopus)

Human pancreatic cancer fusion 2 (HPC2) 1-B3: A novel monoclonal antibody to screen for pancreatic ductal dysplasia

Morgan, T., Hardiman, K., Corless, C., White, S. L., Bonnah, R., Van De Vrugt, H., Sheppard, B., Grompe, M., Cosar, E. F. & Streeter, P., Jan 2013, In : Cancer cytopathology. 121, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Monoclonal Antibodies
Adenocarcinoma
Neoplasms
Fine Needle Biopsy
91 Citations (Scopus)

Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress

Gold, M., Eid, T., Smyk-Pearson, S., Eberling, Y., Swarbrick, G. M., Langley, S. M., Streeter, P., Lewinsohn, D. & Lewinsohn, D., Jan 2013, In : Mucosal Immunology. 6, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
T-Lymphocytes
Phenotype
T-Cell Receptor Genes
Replication Origin
14 Citations (Scopus)

Immune markers of disease severity and treatment response in pediatric acquired aplastic anemia

Sutton, K. S., Shereck, E., Nemecek, E. & Kurre, P., Mar 2013, In : Pediatric Blood and Cancer. 60, 3, p. 455-460 6 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Immune System Diseases
Biomarkers
Pediatrics
Natural Killer Cells
88 Citations (Scopus)

Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening

Tyner, J., Yang, W. F., Bankhead, A., Fan, G., Fletcher, L. B., Bryant, J., Glover, J. M., Chang, B., Spurgeon, S., Fleming, W., Kovacsovics, T., Gotlib, J. R., Oh, S. T., Deininger, M. W., Zwaan, C. M., Den Boer, M. L., Van Den Heuvel-Eibrink, M. M., O'Hare, T., Druker, B. & Loriaux, M., Jan 1 2013, In : Cancer Research. 73, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

Leukemia
Phosphotransferases
Pharmaceutical Preparations
High-Throughput Nucleotide Sequencing
Mutation
117 Citations (Scopus)

RNA trafficking by acute myelogenous leukemia exosomes

Huan, J., Hornick, N. I., Shurtleff, M. J., Skinner, A., Goloviznina, N. A., Roberts, C. & Kurre, P., Jan 15 2013, In : Cancer Research. 73, 2, p. 918-929 12 p.

Research output: Contribution to journalArticle

Exosomes
Acute Myeloid Leukemia
RNA
Bone Marrow
Cell Line
28 Citations (Scopus)

Vesicle trafficking and RNA transfer add complexity and connectivity to Cell-cell communication

Roberts, C. & Kurre, P., Jun 1 2013, In : Cancer Research. 73, 11, p. 3200-3205 6 p.

Research output: Contribution to journalArticle

Transfer RNA
Cell Communication
RNA
Small Untranslated RNA
Lipid Bilayers
2012
165 Citations (Scopus)

Bone marrow failure in fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells

Ceccaldi, R., Parmar, K., Mouly, E., Delord, M., Kim, J. M., Regairaz, M., Pla, M., Vasquez, N., Zhang, Q-S., Pondarre, C., Peffault De Latour, R., Gluckman, E., Cavazzana-Calvo, M., Leblanc, T., Larghero, J., Grompe, M., Socié, G., D'Andrea, A. D. & Soulier, J., Jul 6 2012, In : Cell Stem Cell. 11, 1, p. 36-49 14 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Hematopoietic Stem Cells
DNA Damage
Bone Marrow
DNA Repair-Deficiency Disorders
5 Citations (Scopus)

GILT required for RTL550-CYS-MOG to treat experimental autoimmune encephalomyelitis

Burrows, G. G., Meza-Romero, R., Huan, J., Sinha, S., Mooney, J. L., Vandenbark, A. & Offner, H., Jun 2012, In : Metabolic Brain Disease. 27, 2, p. 143-149 7 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Sulfhydryl Compounds
Interferon-gamma
Oxidoreductases
Bearings (structural)
10 Citations (Scopus)

Intra-hematopoietic cell fusion as a source of somatic variation in the hematopoietic system

Skinner, A., Grompe, M. & Kurre, P., Jun 15 2012, In : Journal of Cell Science. 125, 12, p. 2837-2843 7 p.

Research output: Contribution to journalArticle

Hematopoietic System
Cell Fusion
Ploidies
Myeloid Cells
Genetic Markers
1 Citation (Scopus)

L-leucine alleviates Diamond-Blackfan anemia

Kamimae-Lanning, A. N. & Kurre, P., Sep 13 2012, In : Blood. 120, 11, p. 2157-2158 2 p.

Research output: Contribution to journalArticle

Diamond-Blackfan Anemia
Diamond
Essential Amino Acids
Erythropoiesis
Zebrafish
15 Citations (Scopus)

Multiplex high-throughput gene mutation analysis in acute myeloid leukemia

Dunlap, J., Beadling, C., Warrick, A., Neff, T., Fleming, W., Loriaux, M., Heinrich, M., Kovacsovics, T., Kelemen, K., Leeborg, N., Gatter, K., Braziel, R., Press, R., Corless, C. & Fan, G., Dec 2012, In : Human Pathology. 43, 12, p. 2167-2176 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Mutation
Cytogenetics
Genes
Leukemia
6 Citations (Scopus)

Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody

Liu, G., Dou, S., Akalin, A., Rusckowski, M., Streeter, P., Shultz, L. D. & Greiner, D. L., Jul 2012, In : Nuclear Medicine and Biology. 39, 5, p. 645-651 7 p.

Research output: Contribution to journalArticle

Islets of Langerhans
Transplants
Antibodies
Pancreas
Fluorescent Antibody Technique
2 Citations (Scopus)

Programmed vesicle transfer of green fluorescent protein from a stably transduced cell line to primary hematopoietic cells

Russell, T. B., Skinner, A. & Kurre, P., Jun 5 2012, In : Blood. 119, 22, p. 5330-5332 3 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
MicroRNAs
Animals
Cells
Dendritic Cells
14 Citations (Scopus)

The novel monoclonal antibody HPC2 and N-cadherin distinguish pancreatic ductal adenocarcinoma from cholangiocarcinoma

Hooper, J. E., Morgan, T., Grompe, M., Sheppard, B., Troxell, M., Corless, C. & Streeter, P., Oct 2012, In : Human Pathology. 43, 10, p. 1583-1589 7 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Cadherins
Pancreatic Neoplasms
Adenocarcinoma
Monoclonal Antibodies
2011
75 Citations (Scopus)

A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection

Umashankar, M., Petrucelli, A., Cicchini, L., Caposio, P., Kreklywich, C. N., Rak, M., Bughio, F., Goldman, D., Hamlin, K. L., Nelson, J., Fleming, W., Streblow, D. & Goodrum, F., Dec 2011, In : PLoS Pathogens. 7, 12, e1002444.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Cytomegalovirus
Viruses
Fibroblasts
Infection
2 Citations (Scopus)

Costs and consequences of immunosuppressive therapy in children with aplastic anemia

Shereck, E., Deyell, R. J. & Kurre, P., Jun 2011, In : Haematologica. 96, 6, p. 793-795 3 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Hematopoietic Stem Cell Transplantation
Homologous Transplantation
Immunosuppressive Agents
Immunosuppression
9 Citations (Scopus)

Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model

Liu, G., Dou, S., Cheng, D., Leif, J., Rusckowski, M., Streeter, P., Shultz, L. D., Hnatowich, D. J. & Greiner, D. L., Jun 6 2011, In : Molecular Pharmaceutics. 8, 3, p. 767-773 7 p.

Research output: Contribution to journalArticle

Islets of Langerhans
Transplants
HEK293 Cells
Islets of Langerhans Transplantation
Cell Line
30 Citations (Scopus)

Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers

Dorrell, C., Grompe, M. T., Pan, F. C., Zhong, Y., Canaday, P. S., Shultz, L. D., Greiner, D. L., Wright, C. V., Streeter, P. & Grompe, M., Jun 6 2011, In : Molecular and Cellular Endocrinology. 339, 1-2, p. 144-150 7 p.

Research output: Contribution to journalArticle

Gene expression
Ducts
Labeling
Population
Monoclonal Antibodies
15 Citations (Scopus)
Gliadin
Celiac Disease
Cell Proliferation
Cytokines
T-Lymphocytes
126 Citations (Scopus)

Transcriptomes of the major human pancreatic cell types

Dorrell, C., Schug, J., Lin, C. F., Canaday, P. S., Fox, A. J., Smirnova, O., Bonnah, R., Streeter, P., Stoeckert, C. J., Kaestner, K. H. & Grompe, M., Nov 2011, In : Diabetologia. 54, 11, p. 2832-2844 13 p.

Research output: Contribution to journalArticle

Transcriptome
Endocrine Cells
Acinar Cells
Gene Expression Profiling
Ligands
16 Citations (Scopus)

Treatment of Fanconi anemia patients using fludarabine and low-dose TBI, followed by unrelated donor hematopoietic cell transplantation

Thakar, M. S., Kurre, P., Storb, R., Kletzel, M., Frangoul, H., Pulsipher, M. A., Leisenring, W., Flowers, M. E. D., Sandmaier, B. M., Woolfrey, A. & Kiem, H. P., Apr 2011, In : Bone Marrow Transplantation. 46, 4, p. 539-544 6 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Unrelated Donors
Cell Transplantation
Therapeutics
Chimerism
2010
22 Citations (Scopus)

Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis

Sinha, S., Miller, L., Subramanian, S., McCarty, O., Proctor, T., Meza-Romero, R., Huan, J., Burrows, G. G., Vandenbark, A. & Offner, H., Aug 2010, In : Journal of Neuroimmunology. 225, 1-2, p. 52-61 10 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Antigen-Presenting Cells
T-Cell Antigen Receptor
Up-Regulation
Ligands
12 Citations (Scopus)

Double-negative T cells are non-ALPS-specific markers of immune dysregulation found in patients with aplastic anemia

Russell, T. B. & Kurre, P., Dec 2 2010, In : Blood. 116, 23, p. 5072-5073 2 p.

Research output: Contribution to journalArticle

Autoimmune Lymphoproliferative Syndrome
T-cells
Aplastic Anemia
T-Lymphocyte Subsets
Biomarkers
25 Citations (Scopus)

Endothelial cells mediate the regeneration of hematopoietic stem cells

Li, B., Bailey, A. S., Jiang, S., Liu, B., Goldman, D. & Fleming, W., Jan 2010, In : Stem Cell Research. 4, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Regeneration
Endothelial Cells
Transplantation
Adult Stem Cells
12 Citations (Scopus)

Entry kinetics and cell-cell transmission of surface-bound retroviral vector particles

O'Neill, L. S., Skinner, A., Woodward, J. A. & Kurre, P., May 2010, In : Journal of Gene Medicine. 12, 5, p. 463-476 14 p.

Research output: Contribution to journalArticle

Fibronectins
Extracellular Matrix
Lentivirus
Hematopoietic Stem Cells
Heparin
58 Citations (Scopus)

Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol

Zhang, Q-S., Marquez-Loza, L., Eaton, L., Duncan, A. W., Goldman, D., Anur, P., Watanabe-Smith, K., Rathbun, R. K., Fleming, W., Bagby, G. C. & Grompe, M., Dec 9 2010, In : Blood. 116, 24, p. 5140-5148 9 p.

Research output: Contribution to journalArticle

Bone
Bone Marrow
Cells
Fanconi Anemia
Defects
77 Citations (Scopus)

Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model

Smith, M. S., Goldman, D., Bailey, A. S., Pfaffle, D. L., Kreklywich, C. N., Spencer, D. B., Othieno, F. A., Streblow, D., Garcia, J. V., Fleming, W. & Nelson, J., Sep 16 2010, In : Cell Host and Microbe. 8, 3, p. 284-291 8 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor
Cytomegalovirus
Tissue Donors
Cytomegalovirus Infections
Graft vs Host Disease
70 Citations (Scopus)

Immune evasion by neocartilage-derived chondrocytes: Implications for biologic repair of joint articular cartilage

Adkisson, H. D., Milliman, C., Zhang, X., Mauch, K., Maziarz, R. & Streeter, P., Jan 2010, In : Stem Cell Research. 4, 1, p. 57-68 12 p.

Research output: Contribution to journalArticle

Immune Evasion
Articular Cartilage
Chondrocytes
Joints
T-Lymphocytes
105 Citations (Scopus)

Non-invasive stem cell therapy in a rat model for retinal degeneration and vascular pathology

Wang, S., Lu, B., Girman, S., Duan, J., McFarland, T., Zhang, Q-S., Grompe, M., Adamus, G., Appukuttan, B. & Lund, R., Feb 15 2010, In : PLoS One. 5, 2, e9200.

Research output: Contribution to journalArticle

Retinal Vessels
Retinal Degeneration
Pathology
Cell- and Tissue-Based Therapy
Stem cells

Paroxysmal nocturnal haemoglobinuria clones are part of the immune dysregulation in hepatitis-associated aplastic anaemia

Russell, T. B., Eroglu, Y., Zhang, Z. & Kurre, P., Jan 2010, In : Alimentary Pharmacology and Therapeutics. 31, 1, p. 164-165 2 p.

Research output: Contribution to journalArticle

Paroxysmal Hemoglobinuria
Aplastic Anemia
Immunosuppressive Agents
Hepatitis
Clone Cells
153 Citations (Scopus)

The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage

Adkisson, H. D., Martin, J. A., Amendola, R. L., Milliman, C., Mauch, K. A., Katwal, A. B., Seyedin, M., Amendola, A., Streeter, P. & Buckwalter, J. A., Jul 2010, In : American Journal of Sports Medicine. 38, 7, p. 1324-1333 10 p.

Research output: Contribution to journalArticle

Articular Cartilage
Chondrocytes
Proteoglycans
Cartilage
Collagen Type II
2009
37 Citations (Scopus)

Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds

Kampa, K. M., Acoba, J. D., Chen, D., Gay, J., Lee, H., Beemer, K., Padiernos, E., Boonmark, N., Zhu, Z., Fan, A. C., Bailey, A. S., Fleming, W., Corless, C., Felsher, D. W., Naumovski, L. & Lopez, C., Mar 17 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4390-4395 6 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
Proteins
Thymocytes
Gastrin-Secreting Cells
1 Citation (Scopus)

Avoiding lentiviral transduction culture induced MSC senescence: Letter to the editor

Pan, Y. W. & Kurre, P., Jun 2009, In : Journal of Cellular and Molecular Medicine. 13, 6, p. 1186-1187 2 p.

Research output: Contribution to journalArticle

Genetic Transduction
Lentivirus
Cell Aging
Telomerase
Mesenchymal Stromal Cells
76 Citations (Scopus)

BMP4 regulates the hematopoietic stem cell niche

Goldman, D., Bailey, A. S., Pfaffle, D. L., Al Masri, A., Christian, J. L. & Fleming, W., Nov 12 2009, In : Blood. 114, 20, p. 4393-4401 9 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 4
Stem Cell Niche
Hematopoietic Stem Cells
Stem cells
Hematopoiesis
16 Citations (Scopus)

Cellular microvesicle pathways can be targeted to transfer genetic information between non-immune cells

Skinner, A., O'Neil, S. L. & Kurre, P., Jul 13 2009, In : PLoS One. 4, 7, e6219.

Research output: Contribution to journalArticle

Genes
Transfer RNA
Genome
cells
transfer RNA
45 Citations (Scopus)

Clinical scale expanded adult pluripotent stem cells prevent graft-versus-host disease

Kovacsovics-Bankowski, M., Streeter, P., Mauch, K. A., Frey, M. R., Raber, A., Hof, W. V. T., Deans, R. & Maziarz, R., 2009, In : Cellular Immunology. 255, 1-2, p. 55-60 6 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Adult Stem Cells
Graft vs Host Disease
Stem Cells
Multipotent Stem Cells
17 Citations (Scopus)

CXCR4 but not CXCR7 is mainly implicated in ocular leukocyte trafficking during ovalbumin-induced acute uveitis

Zhang, Z., Zhong, W., Hall, M. J., Kurre, P., Spencer, D., Skinner, A., O'Neill, S., Xia, Z. & Rosenbaum, J. J., Oct 2009, In : Experimental Eye Research. 89, 4, p. 522-531 10 p.

Research output: Contribution to journalArticle

Uveitis
Ovalbumin
Leukocytes
T-Lymphocytes
Chemokine Receptors
28 Citations (Scopus)

Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm

Gadue, P., Gouon-Evans, V., Cheng, X., Wandzioch, E., Zaret, K. S., Grompe, M., Streeter, P. & Keller, G. M., Sep 2009, In : Stem Cells. 27, 9, p. 2103-2113 11 p.

Research output: Contribution to journalArticle

Endoderm
Monoclonal Antibodies
Embryonic Stem Cells
Embryonic Structures
Cell Culture Techniques

Genetic correction of hematopoiesis in fanconi anemia: The case for a non-HSC-autonomous defect

Skinner, A. & Kurre, P., 2009, In : Molecular Therapy. 17, 8, p. 1313-1315 3 p.

Research output: Contribution to journalArticle

CD34 Antigens
Fanconi Anemia
Genetic Vectors
Lentivirus
Hematopoiesis
28 Citations (Scopus)

Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis

Goldman, D., Donley, N. & Christian, J. L., Mar 2009, In : Mechanisms of Development. 126, 3-4, p. 117-127 11 p.

Research output: Contribution to journalArticle

Organogenesis
Allantois
Alleles
Skeleton
Genes
71 Citations (Scopus)

Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis

Vandenbark, A., Huan, J., Agotsch, M., La Tocha, D., Goelz, S., Offner, H., Lanker, S. & Bourdette, D., Oct 30 2009, In : Journal of Neuroimmunology. 215, 1-2, p. 125-128 4 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Interferons
Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Regulatory T-Lymphocytes
2 Citations (Scopus)

MRI findings in aplastic anemia

De Mola, R. L. & Kurre, P., Nov 2009, In : American Journal of Hematology. 84, 11, p. 754 1 p.

Research output: Contribution to journalArticle

Bone Marrow Examination
Pancytopenia
Aplastic Anemia
Pelvis
Blood Cells
1 Citation (Scopus)
Diamond-Blackfan Anemia
Pancytopenia
Adenosine Deaminase
Aplastic Anemia
Young Adult
2008
10 Citations (Scopus)

CXCR4 induction in hematopoietic progenitor cells from Fanca-/-, -c-/-, and -d2-/- mice

Skinner, A., O'Neill, S. L., Grompe, M. & Kurre, P., Mar 2008, In : Experimental Hematology. 36, 3, p. 273-282 10 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Hematopoietic Stem Cells
Stem Cells
Chimerism
Genotype
47 Citations (Scopus)

Hematopoietic stem cells contribute to lymphatic endothelium

Jiang, S., Bailey, A. S., Goldman, D., Swain, J. R., Wong, M., Streeter, P. & Fleming, W., Nov 26 2008, In : PLoS One. 3, 11, e3812.

Research output: Contribution to journalArticle

Lymphatic Endothelium
Hematopoietic Stem Cells
endothelium
Stem cells
Endothelial cells