Research Output

2020

Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload

Wortham, A. M., Goldman, D. C., Chen, J., Fleming, W. H., Zhang, A. S., Enns, C. A. & Peter Guengerich, F., Mar 20 2020, In : Journal of Biological Chemistry. 295, 12, p. 3906-3917 12 p.

Research output: Contribution to journalArticle

2019

Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche

Abdelhamed, S., Butler, J. T., Doron, B., Halse, A., Nemecek, E., Wilmarth, P., Marks, D., Chang, B., Horton, T. & Kurre, P., Jul 1 2019, In : EMBO Reports. 20, 7, e47546.

Research output: Contribution to journalArticle

Transmissible ER stress shapes the leukemic microenvironment

Butler, J. T. & Kurre, P., Jun 1 2019, In : Oncotarget. 10, 41, p. 4080-4082 3 p.

Research output: Contribution to journalEditorial

Open Access
2018

Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop

Li, K., Rodosthenous, R. S., Kashanchi, F., Gingeras, T., Gould, S. J., Kuo, L. S., Kurre, P., Lee, H., Leonard, J. N., Liu, H., Lombo, T. B., Momma, S., Nolan, J. P., Ochocinska, M. J., Pegtel, D. M., Sadovsky, Y., Sánchez-Madrid, F., Valdes, K. M., Vickers, K. C., Weaver, A. M. & 5 others, Witwer, K. W., Zeng, Y., Das, S., Raffai, R. L. & Howcroft, T. K., Apr 5 2018, In : JCI Insight. 3, 7

Research output: Contribution to journalReview article

Open Access
18 Scopus citations

Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model

Zhang, Q-S., Deater, M., Phan, N., Marcogliese, A., Major, A., Guinan, E. C. & Grompe, M., Jan 1 2018, (Accepted/In press) In : Pediatric Blood and Cancer.

Research output: Contribution to journalArticle

1 Scopus citations

Concise Review: Adaptation of the Bone Marrow Stroma in Hematopoietic Malignancies: Current Concepts and Models

Doron, B., Handu, M. & Kurre, P., Jan 1 2018, (Accepted/In press) In : Stem Cells.

Research output: Contribution to journalArticle

7 Scopus citations

Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: A “U-shaped” relationship

Shi, M., Flores, B., Li, P., Gillings, N., McMillan, K. L., Ye, J., Huang, L. J. S., Sidhu, S. S., Zhong, Y. P., Grompe, M. T., Streeter, P., Moe, O. W. & Hu, M. C., Apr 1 2018, In : American Journal of Physiology - Renal Physiology. 314, 4, p. F501-F516

Research output: Contribution to journalArticle

3 Scopus citations

Extracellular vesicles in the hematopoietic microenvironment

Butler, J. T., Abdelhamed, S. & Kurre, P., Feb 28 2018, In : Haematologica. 103, 3, p. 382-394 13 p.

Research output: Contribution to journalReview article

15 Scopus citations

Hematopoietic development: A gap in our understanding of inherited bone marrow failure

Kurre, P., Jan 1 2018, (Accepted/In press) In : Experimental Hematology.

Research output: Contribution to journalArticle

Humanised recombinant antibody fragments bind human pancreatic islet cells

Buenafe, A. C. & Streeter, P., Jan 1 2018, (Accepted/In press) In : Journal of Immunological Methods.

Research output: Contribution to journalArticle

LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma

Klug, L. R., Bannon, A. E., Javidi-Sharifi, N., Town, A., Fleming, W., VanSlyke, J. K., Musil, L., Fletcher, J. A., Tyner, J. & Heinrich, M., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

2 Scopus citations

Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations

Smith, N. R., Swain, J. R., Davies, P., Gallagher, A. C., Parappilly, M. S., Beach, C. Z., Streeter, P., Williamson, I. A., Magness, S. T. & Wong, M., Jan 1 2018, In : CMGH. 6, 1, p. 79-96 18 p.

Research output: Contribution to journalArticle

4 Scopus citations

Stem cell therapy for fanconi anemia

Zhang, Q-S., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 19-28 10 p. (Advances in Experimental Medicine and Biology; vol. 1083).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Transmissible ER stress reconfigures the AML bone marrow compartment

Doron, B., Abdelhamed, S., Butler, J. T., Hashmi, S. K., Horton, T. M. & Kurre, P., Jan 1 2018, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

6 Scopus citations
2017
1 Scopus citations

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors

Cogger, K. F., Sinha, A., Sarangi, F., McGaugh, E. C., Saunders, D., Dorrell, C., Mejia-Guerrero, S., Aghazadeh, Y., Rourke, J. L., Screaton, R. A., Grompe, M., Streeter, P. R., Powers, A. C., Brissova, M., Kislinger, T. & Nostro, M. C., Dec 1 2017, In : Nature communications. 8, 1, 331.

Research output: Contribution to journalArticle

32 Scopus citations

IFPA meeting 2016 workshop report I: Genomic communication, bioinformatics, trophoblast biology and transport systems

Albrecht, C., Baker, J. C., Blundell, C., Chavez, S. L., Carbone, L., Chamley, L., Hannibal, R. L., Illsley, N., Kurre, P., Laurent, L. C., McKenzie, C., Morales-Prieto, D., Pantham, P., Paquette, A., Powell, K., Price, N., Rao, B. M., Sadovsky, Y., Salomon, C., Tuteja, G. & 2 others, Wilson, S. & O'Tierney-Ginn, P. F., Dec 2017, In : Placenta. 60, p. S5-S9

Research output: Contribution to journalArticle

2 Scopus citations

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model

Janghorban, M., Langer, E. M., Wang, X., Zachman, D., Daniel, C. J., Hooper, J., Fleming, W., Agarwal, A. & Sears, R., Nov 1 2017, In : PLoS One. 12, 11, e0188910.

Research output: Contribution to journalArticle

5 Scopus citations

Understanding the bone marrow microenvironment in hematologic malignancies: A focus on chemokine, integrin, and extracellular vesicle signaling

Sison, E. A. R., Kurre, P. & Kim, Y. M., Dec 5 2017, (Accepted/In press) In : Pediatric Hematology and Oncology. p. 1-14 14 p.

Research output: Contribution to journalArticle

2016
27 Scopus citations

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

Hornick, N. I., Doron, B., Abdelhamed, S., Huan, J., Harrington, C. A., Shen, R., Cambronne, X. A., Verghese, S. C. & Kurre, P., Sep 6 2016, In : Science signaling. 9, 444, ra88.

Research output: Contribution to journalArticle

50 Scopus citations

Anchored lentiviral vector episomes for stem cell gene therapy in fanconi anemia

Verghese, S. C. & Kurre, P., Oct 1 2016, In : Current Gene Therapy. 16, 5, p. 329-337 9 p.

Research output: Contribution to journalReview article

2 Scopus citations

Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2−/− Hematopoietic Stem and Progenitor Cells

Yoon, Y. M., Storm, K. J., Kamimae-Lanning, A. N., Goloviznina, N. A. & Kurre, P., Nov 8 2016, In : Stem Cell Reports. 7, 5, p. 840-853 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Human islets contain four distinct subtypes of β cells

Dorrell, C., Schug, J., Canaday, P. S., Russ, H. A., Tarlow, B. D., Grompe, M. T., Horton, T., Hebrok, M., Streeter, P., Kaestner, K. H. & Grompe, M., Jul 11 2016, In : Nature Communications. 7, 11756.

Research output: Contribution to journalArticle

135 Scopus citations

Mesenchymal stromal cell-derived extracellular vesicles promote myeloid-biased multipotent hematopoietic progenitor expansion via toll-like receptor engagement

Goloviznina, N. A., Verghese, S. C., Yoon, Y. M., Taratula, O., Marks, D. & Kurre, P., Nov 18 2016, In : Journal of Biological Chemistry. 291, 47, p. 24607-24617 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice

Zhang, Q. S., Tang, W., Deater, M., Phan, N., Marcogliese, A. N., Li, H., Al-Dhalimy, M., Major, A., Olson, S., Monnat, R. J. & Grompe, M., Dec 15 2016, In : Blood. 128, 24, p. 2774-2784 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Phenotypic correction of Fanconi anemia cells in the murine bone marrow after carrier cell mediated delivery of lentiviral vector

Chakkaramakkil Verghese, S., Goloviznina, N. A. & Kurre, P., Nov 19 2016, In : Stem Cell Research and Therapy. 7, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Huan, J., Hornick, N. I., Goloviznina, N. A., Kamimae-Lanning, A. N., David, L., Wilmarth, P., Mori, M. T., Chevillet, J. R., Narla, A., Roberts, C., Loriaux, M., Chang, B. & Kurre, P., Jun 25 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

42 Scopus citations

GATA2 regulates Wnt signaling to promote primitive red blood cell fate

Mimoto, M. S., Kwon, S., Green, Y. S., Goldman, D. & Christian, J. L., Nov 1 2015, In : Developmental Biology. 407, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hope and hype surrounding circulating microRNA as potential next generation AML biomarkers

Abdelhamed, S. & Kurre, P., 2015, (Accepted/In press) In : Leukemia Research.

Research output: Contribution to journalArticle

1 Scopus citations

Intestinal microbiota-derived metabolomic blood plasma markers for prior radiation injury

Broin, P., Vaitheesvaran, B., Saha, S., Hartil, K., Chen, E. I., Goldman, D., Fleming, W. H., Kurland, I. J., Guha, C. & Golden, A., Jan 1 2015, In : International Journal of Radiation Oncology Biology Physics. 91, 2, p. 360-367 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Maternal high-fat diet and obesity compromise fetal hematopoiesis

Kamimae-Lanning, A. N., Krasnow, S. M., Goloviznina, N. A., Zhu, X., Roth-Carter, Q. R., Levasseur, P. R., Jeng, S., McWeeney, S. K., Kurre, P. & Marks, D. L., Jan 1 2015, In : Molecular Metabolism. 4, 1, p. 25-38 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

New markers for tracking endoderm induction and hepatocyte differentiation from human pluripotent stem cells

Holtzinger, A., Streeter, P., Sarangi, F., Hillborn, S., Niapour, M., Ogawa, S. & Keller, G., Dec 15 2015, In : Development (Cambridge). 142, 24, p. 4253-4265 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Novel surface markers directed against adult human gallbladder

Galivo, F. H., Dorrell, C. S., Grompe, M., Zhong, Y. P., Streeter, P. & Grompe, M., Jul 1 2015, In : Stem Cell Research. 15, 1, p. 172-181 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling

Zhang, Q. S., Benedetti, E., Deater, M., Schubert, K., Major, A., Pelz, C., Impey, S., Marquez-Loza, L., Rathbun, R. K., Kato, S., Bagby, G. C. & Grompe, M., Jan 13 2015, In : Stem Cell Reports. 4, 1, p. 90-102 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia

Geng, H., Hurtz, C., Lenz, K. B., Chen, Z., Baumjohann, D., Thompson, S., Goloviznina, N. A., Chen, W. Y., Huan, J., LaTocha, D., Ballabio, E., Xiao, G., Lee, J. W., Deucher, A., Qi, Z., Park, E., Huang, C., Nahar, R., Kweon, S. M., Shojaee, S. & 18 others, Chan, L. N., Yu, J., Kornblau, S. M., Bijl, J. J., Ye, B. H., Mark Ansel, K., Paietta, E., Melnick, A., Hunger, S. P., Kurre, P., Tyner, J. W., Loh, M. L., Roeder, R. G., Druker, B. J., Burger, J. A., Milne, T. A., Chang, B. H. & Müschen, M., Mar 9 2015, In : Cancer Cell. 27, 3, p. 409-425 17 p.

Research output: Contribution to journalArticle

57 Scopus citations

Serum Exosome MicroRNA as a minimally-invasive early biomarker of AML

Hornick, N. I., Huan, J., Doron, B., Goloviznina, N. A., Lapidus, J., Chang, B. H. & Kurre, P., Jun 12 2015, In : Scientific Reports. 5, 11295.

Research output: Contribution to journalArticle

83 Scopus citations

The corepressor Rcor1 is essential for normal myeloerythroid lineage differentiation

Yao, H., Goldman, D. C., Fan, G., Mandel, G. & Fleming, W. H., Nov 2015, In : Stem Cells. 33, 11, p. 3304-3314 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice

Zhang, Q. S., Deater, M., Schubert, K., Marquez-Loza, L., Pelz, C., Sinclair, D. A. & Grompe, M., Jul 1 2015, In : Stem Cell Research. 15, 1, p. 130-140 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice

Goldman, D. C., Alexeev, V., Lash, E., Guha, C., Rodeck, U. & Fleming, W. H., Mar 1 2015, In : Radiation research. 183, 3, p. 338-344 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

De Togni, P., Goellner, J., Ruddle, N. H., Streeter, P. R., Fick, A., Mariathasan, S., Smith, S. C., Carlson, R., Shornick, L. P., Strauss-Schoenberger, J., Russell, J. H., Karr, R. & Chaplint, D. D., Mar 1 2014, In : Journal of Immunology. 192, 5, p. 2007-2014 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Corepressor Rcor1 is essential for murine erythropoiesis

Yao, H., Goldman, D. C., Nechiporuk, T., Kawane, S., McWeeney, S. K., Tyner, J. W., Fan, G., Kerenyi, M. A., Orkin, S. H., Fleming, W. H. & Mandel, G., May 15 2014, In : Blood. 123, 20, p. 3175-3184 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model

Zhang, Q. S., Marquez-Loza, L., Sheehan, A. M., Watanabe-Smith, K., Eaton, L., Benedetti, E., Major, A., Schubert, K., Deater, M., Joseph, E. & Grompe, M., Apr 1 2014, In : Pediatric Blood and Cancer. 61, 4, p. 740-742 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Functional integration of acute myeloid leukemia into the vascular niche

Cogle, C. R., Goldman, D. C., Madlambayan, G. J., Leon, R. P., Al Masri, A., Clark, H. A., Asbaghi, S. A., Tyner, J. W., Dunlap, J., Fan, G., Kovacsovics, T., Liu, Q., Meacham, A., Hamlin, K. L., Hromas, R. A., Scott, E. W. & Fleming, W. H., Oct 1 2014, In : Leukemia. 28, 10, p. 1978-1987 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
20 Scopus citations

Pearson marrow pancreas syndrome in patients suspected to have Diamond-Blackfan anemia

Gagne, K. E., Ghazvinian, R., Yuan, D., Zon, R. L., Storm, K., Mazur-Popinska, M., Andolina, L., Bubala, H., Golebiowska, S., Higman, M. A., Kalwak, K., Kurre, P., Matysiak, M., Niewiadomska, E., Pels, S., Petruzzi, M. J., Pobudejska-Pieniazek, A., Szczepanski, T., Fleming, M. D., Gazda, H. T. & 1 others, Agarwal, S., Jul 17 2014, In : Blood. 124, 3, p. 437-440 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Pillars article: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994. 264: 703-707.

De Togni, P., Goellner, J., Ruddle, N. H., Streeter, P. R., Andrea, F., Mariathasan, S., Smith, S. C., Carlson, R., Shornick, L. P., Strauss-Schoenberger, J., Russell, J. H., Karr, R. & Chaplin, D. D., Mar 1 2014, In : Journal of immunology (Baltimore, Md. : 1950). 192, 5, p. 2010-2014 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

S/MAR sequence confers long-term mitotic stability on non-integrating lentiviral vector episomes without selection

Verghese, S. C., Goloviznina, N. A., Skinner, A. M., Lipps, H. J. & Kurre, P., Apr 2014, In : Nucleic acids research. 42, 7, p. e53

Research output: Contribution to journalArticle

26 Scopus citations

The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar

Dorrell, C., Tarlow, B., Wang, Y., Canaday, P. S., Haft, A., Schug, J., Streeter, P. R., Finegold, M. J., Shenje, L. T., Kaestner, K. H. & Grompe, M., Sep 2014, In : Stem Cell Research. 13, 2, p. 275-283 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2013

A novel regulatory pathway for autoimmune disease: Binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance

Vandenbark, A. A., Meza-Romero, R., Benedek, G., Andrew, S., Huan, J., Chou, Y. K., Buenafe, A. C., Dahan, R., Reiter, Y., Mooney, J. L., Offner, H. & Burrows, G. G., Feb 1 2013, In : Journal of Autoimmunity. 40, 1, p. 96-110 15 p.

Research output: Contribution to journalArticle

28 Scopus citations