Research Output

1997

Sustained multilineage engraftment of allogeneic hematopoietic stem cells in NOD/SCID mice after in utero transplantation

Archer, D. R., Turner, C. W., Yeager, A. M. & Fleming, W., Oct 15 1997, In : Blood. 90, 8, p. 3222-3229 8 p.

Research output: Contribution to journalArticle

55 Scopus citations
1998

In utero transplantation of human fetal haemopoietic cells in NOD/SCID mice

Turner, C. W., Archer, D. R., Wong, J., Yeager, A. M. & Fleming, W., 1998, In : British Journal of Haematology. 103, 2, p. 326-334 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

MHC class II gene silencing in trophoblast cells is caused by inhibition of CIITA expression

Morris, A. C., Riley, J. L., Fleming, W. & Boss, J. M., Dec 1998, In : American Journal of Reproductive Immunology. 40, 6, p. 385-394 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

The Roles of CYP3A and CYP2B Isoforms in Hepatic Bioactivation and Detoxification of the Pyrrolizidine Alkaloid Senecionine in Sheep and Hamsters

Huan, J., Miranda, C. L., Buhler, D. R. & Cheeke, P. R., Aug 1998, In : Toxicology and Applied Pharmacology. 151, 2, p. 229-235 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
1999

Administration of daniplestim and granulocyte colony-stimulating factor for the mobilization of hematopoietic progenitor cells in nonhuman primates

Fleming, W., Lankford-Turner, P., Turner, C. W., Wong, J., Strobert, E. & McKearn, J. P., 1999, In : Biology of Blood and Marrow Transplantation. 5, 1, p. 8-14 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Interactions in sheep between tall fescue ergot alkaloids and hepatotoxic carbon tetrachloride and senecio pyrrolizidine alkaloids

Debessai, W. T., Huan, J. & Cheeke, P. R., Jun 1999, In : Veterinary and Human Toxicology. 41, 3, p. 129-133 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
15 Scopus citations
2000

Alteration of epithelial cell transferrin-iron homeostasis by Neisseria meningitidis and Neisseria gonorrhoeae

Bonnah, R., Lee, S. W., Vasquez, B. L., Enns, C. & So, M., 2000, In : Cellular Microbiology. 2, 3, p. 207-218 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Phase I/Ii study of combination high-dose therapy with busulfan, thiotepa, and total body irradiation (TBI) for the treatment of aggressive multiple myeloma

Leis, J. F., Hansen, K. S., Brunvand, M. W. & Fleming, W., 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

2001
19 Scopus citations
2002

Adult blood vessels restore host hematopoiesis following lethal irradiation

Montfort, M. J., Olivares, C. R., Mulcahy, J. M. & Fleming, W., 2002, In : Experimental Hematology. 30, 8, p. 950-956 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Characterization of dendritic cells generated in vivo by an E. coli derived chimeric dual receptor agonist

Kahn, L. E., Doshi, P., McGarity, K. L., Yu, M., Bono, C. P., Lie, W. R., Rankin, A. M., Smidt, M. L., Streeter, P., Klein, B. K., Welply, J. K. & Woulfe, S. L., Dec 1 2002, In : Medical Science Monitor. 8, 12

Research output: Contribution to journalArticle

Toxic megacolon: A life-threatening complication of high-dose therapy and autologous stem cell transplantation among patients with AL amyloidosis

Hayes-Lattin, B., Curtin, P. T., Fleming, W., Leis, J. F., Stepan, D. E., Schubach, S. & Maziarz, R., Sep 2002, In : Bone Marrow Transplantation. 30, 5, p. 279-285 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2003

Activation of the G-CSF and Flt-3 receptors protects hematopoietic stem cells from lethal irradiation

Streeter, P., Dudley, L. Z. & Fleming, W., Nov 2003, In : Experimental Hematology. 31, 11, p. 1119-1125 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Converging roads: Evidence for an adult hemangioblast

Bailey, A. S. & Fleming, W., Nov 2003, In : Experimental Hematology. 31, 11, p. 987-993 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation

Wang, C., Mooney, J. L., Meza-Romero, R., Chou, Y. K., Huan, J., Vandenbark, A., Offner, H. & Burrows, G. G., Aug 15 2003, In : Journal of Immunology. 171, 4, p. 1934-1940 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice

Vandenbark, A., Rich, C., Mooney, J., Zamora, A., Wang, C., Huan, J., Fugger, L., Offner, H., Jones, R. & Burrows, G. G., Jul 1 2003, In : Journal of Immunology. 171, 1, p. 127-133 7 p.

Research output: Contribution to journalArticle

70 Scopus citations
2004

CD25 expression distinguishes functionally distinct alloreactive CD4+ CD134+ (OX40+) T-cell subsets in acute graft-versus-host disease

Streeter, P., Zhang, X., Tittle, T. V., Schön, C. N., Weinberg, A. D. & Maziarz, R., May 2004, In : Biology of Blood and Marrow Transplantation. 10, 5, p. 298-309 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis

Bonnah, R., Muckenthaler, M. U., Carlson, H., Minana, B., Enns, C., Hentze, M. W. & So, M., May 2004, In : Cellular Microbiology. 6, 5, p. 473-484 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Monomeric Recombinant TCR Ligand Reduces Relapse Rate and Severity of Experimental Autoimmune Encephalomyelitis in SJL/J Mice through Cytokine Switch

Huan, J., Subramanian, S., Jones, R., Rich, C., Link, J., Mooney, J., Bourdette, D., Vandenbark, A., Burrows, G. G. & Offner, H., Apr 1 2004, In : Journal of Immunology. 172, 7, p. 4556-4566 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Myelomonocytic cells are sufficient for therapeutic cell fusion in liver

Willenbring, H., Bailey, A. S., Foster, M., Akkari, Y., Dorrell, C., Olson, S., Finegold, M., Fleming, W. & Grompe, M., Jul 2004, In : Nature Medicine. 10, 7, p. 744-748 5 p.

Research output: Contribution to journalArticle

338 Scopus citations

PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors

Baumann, C. I., Bailey, A. S., Li, W., Ferkowicz, M. J., Yoder, M. C. & Fleming, W., Aug 15 2004, In : Blood. 104, 4, p. 1010-1016 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells

Huan, J., Streicher, J. M., Bleyle, L. A. & Koop, D., Sep 15 2004, In : Toxicology and Applied Pharmacology. 199, 3, p. 332-343 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

T-cell hybridoma specific for myelin oligodendrocyte glycoprotein-35-55 peptide produced from HLA-DRB1*1501-transgenic mice

Chou, Y. K., Culbertson, N., Rich, C., LaTocha, D., Buenafe, A. C., Huan, J., Link, J., Wands, J. M., Born, W. K., Offner, H., Bourdette, D., Burrows, G. G. & Vandenbark, A., Sep 1 2004, In : Journal of Neuroscience Research. 77, 5, p. 670-680 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Toll-like receptor 4 and CD14 expression in human ciliary body and TLR-4 in human iris endothelial cells

Brito, B. E., Zamora, D. O., Bonnah, R., Pan, Y., Planck, S. & Rosenbaum, J. J., Aug 2004, In : Experimental Eye Research. 79, 2, p. 203-208 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells

Bailey, A. S., Jiang, S., Afentoulis, M., Baumann, C. I., Schroeder, D. A., Olson, S., Wong, M. & Fleming, W., Jan 1 2004, In : Blood. 103, 1, p. 13-19 7 p.

Research output: Contribution to journalArticle

216 Scopus citations

Transplanted human bone marrow contributes to vascular endothelium

Jiang, S., Walker, L., Afentoulis, M., Anderson, D. A., Jauron-Mills, L., Corless, C. & Fleming, W., Nov 30 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 48, p. 16891-16896 6 p.

Research output: Contribution to journalArticle

115 Scopus citations
2005

Diagnosis and treatment of children with aplastic anemia

Kurre, P., Johnson, F. L. & Deeg, H. J., Oct 2005, In : Pediatric Blood and Cancer. 45, 6, p. 770-780 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Donor marker infidelity in transgenic hematopoietic stem cells

Anderson, D. A., Wu, Y., Jiang, S., Zhang, X., Streeter, P., Spangrude, G. J., Archer, D. R. & Fleming, W., May 2005, In : Stem Cells. 23, 5, p. 638-643 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Endothelial cell-specific markers: Going . . . going . . . gone

Fleming, W., Aug 1 2005, In : Blood. 106, 3, p. 769 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Lipooligosaccharide-independent alteration of cellular homeostasis in Neisseria meningitidis-infected epithelial cells

Bonnah, R., Hoelter, J., Steeghs, L., Enns, C., So, M. & Muckenthaler, M. U., Jun 2005, In : Cellular Microbiology. 7, 6, p. 869-885 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Rationally designed mutations convert complexes of human recombinant T cell receptor ligands into monomers that retain biological activity

Huan, J., Meza-Romero, R., Mooney, J. L., Chou, Y. K., Edwards, D. M., Rich, C., Link, J., Vandenbark, A., Bourdette, D., Bächinger, H. P. & Burrows, G. G., Jan 2005, In : Journal of Chemical Technology and Biotechnology. 80, 1, p. 2-12 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Treatment of passive experimental autoimmune encephalomyelitis in SJL mice with a recombinant TCR ligand induces IL-13 and prevents axonal injury

Offner, H., Subramanian, S., Wang, C., Afentoulis, M., Vandenbark, A., Huan, J. & Burrows, G. G., Sep 15 2005, In : Journal of Immunology. 175, 6, p. 4103-4111 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2006

Bone marrow-derived cells fuse with normal and transformed intestinal stem cells

Rizvi, A. Z., Swain, J. R., Davies, P., Bailey, A. S., Decker, A. D., Willenbring, H., Grompe, M., Fleming, W. & Wong, M., Apr 18 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 16, p. 6321-6325 5 p.

Research output: Contribution to journalArticle

199 Scopus citations

Ectodermally derived steel/stem cell factor functions non-cell autonomously during primitive erythropoiesis in Xenopus

Goldman, D., Berg, L. K., Heinrich, M. & Christian, J. L., Apr 15 2006, In : Blood. 107, 8, p. 3114-3121 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

hnRNP A1 associates with telomere ends and stimulates telomerase activity

Zhang, Q-S., Manche, L., Xu, R. M. & Krainer, A. R., Jun 2006, In : RNA. 12, 6, p. 1116-1128 13 p.

Research output: Contribution to journalArticle

109 Scopus citations

In vivo genetic selection of renal proximal tubules

Held, P. K., Al-Dhalimy, M., Willenbring, H., Akkari, Y., Jiang, S., Torimaru, Y., Olson, S., Fleming, W., Finegold, M. & Grompe, M., Jan 2006, In : Molecular Therapy. 13, 1, p. 49-58 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Modification of the Woodruff-Stamper assay demonstrates binding of Toxoplasma gondii tachyzoites to retinal vascular endothelium

Chipps, T. J., Streeter, P., Franc, D. T., Neumeyer, K., Planck, S., Rosenbaum, J. J. & Smith, J. R., May 30 2006, In : Journal of Immunological Methods. 312, 1-2, p. 209-213 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mouse models of hematopoietic engraftment: Limitations of transgenic green fluorescent protein strains and a high-performance liquid chromatography approach to analysis of erythroid chimerism

Spangrude, G. J., Cho, S., Guedelhoefer, O., VanWoerkom, R. C. & Fleming, W., 2006, In : Stem Cells. 24, 9, p. 2045-2051 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity

Goldman, D., Hackenmiller, R., Nakayama, T., Sopory, S., Wong, C., Kulessa, H. & Christian, J. L., May 2006, In : Development. 133, 10, p. 1933-1942 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Myeloid lineage progenitors give rise to vascular endothelium

Bailey, A. S., Willenbring, H., Jiang, S., Anderson, D. A., Schroeder, D. A., Wong, M., Grompe, M. & Fleming, W., Aug 29 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 35, p. 13156-13161 6 p.

Research output: Contribution to journalArticle

145 Scopus citations

Rapid 1-hour transduction of whole bone marrow leads to long-term repopulation of murine recipients with lentivirus-modified hematopoietic stem cells

Kurre, P., Anandakumar, P. & Kiem, H. P., Feb 2006, In : Gene Therapy. 13, 4, p. 369-373 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells

Fontenot, A. P., Keizer, T. S., McCleskey, M., Mack, D. G., Meza-Romero, R., Huan, J., Edwards, D. M., Chou, Y. K., Vandenbark, A., Scott, B. & Burrows, G. G., Sep 15 2006, In : Journal of Immunology. 177, 6, p. 3874-3883 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2007
40 Scopus citations

GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesis

Dalgin, G., Goldman, D., Donley, N., Ahmed, R., Eide, C. A. & Christian, J. L., Oct 15 2007, In : Developmental Biology. 310, 2, p. 454-469 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Multiarm high-throughput integration site detection: Limitations of LAM-PCR technology and optimization for clonal analysis

Harkey, M. A., Kaul, R., Jacobs, M. A., Kurre, P., Bovee, D., Levy, R. & Blau, C. A., Jun 2007, In : Stem Cells and Development. 16, 3, p. 381-392 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Prolonged adherence of human immunodeficiency virus-derived vector particles to hematopoietic target cells leads to secondary transduction in vitro and in vivo

Pan, Y. W., Scarlett, J. M., Luoh, T. T. & Kurre, P., Jan 2007, In : Journal of Virology. 81, 2, p. 639-649 11 p.

Research output: Contribution to journalArticle

25 Scopus citations
2008

CXCR4 induction in hematopoietic progenitor cells from Fanca-/-, -c-/-, and -d2-/- mice

Skinner, A., O'Neill, S. L., Grompe, M. & Kurre, P., Mar 2008, In : Experimental Hematology. 36, 3, p. 273-282 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Hematopoietic stem cells contribute to lymphatic endothelium

Jiang, S., Bailey, A. S., Goldman, D., Swain, J. R., Wong, M., Streeter, P. & Fleming, W., Nov 26 2008, In : PLoS One. 3, 11, e3812.

Research output: Contribution to journalArticle

48 Scopus citations

Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers

Dorrell, C., Abraham, S. L., Lanxon-Cookson, K. M., Canaday, P. S., Streeter, P. & Grompe, M., Sep 2008, In : Stem Cell Research. 1, 3, p. 183-194 12 p.

Research output: Contribution to journalArticle

63 Scopus citations