Michael Axthelm

Associate Scientist

  • 6636 Citations
  • 40 h-Index
1978 …2020
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Research Output 1981 2019

  • 6636 Citations
  • 40 h-Index
  • 128 Article
  • 2 Comment/debate
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Article
2019
1 Citation (Scopus)

Cytomegalovirus vectors expressing Plasmodium knowlesi antigens induce immune responses that delay parasitemia upon sporozoite challenge

Hansen, S., Womack, J., Scholz, I., Renner, A., Edgel, K. A., Xu, G., Ford, J. C., Grey, M., St. Laurent, B., Turner, J. M., Planer, S., Legasse, A. W., Richie, T. L., Aguiar, J. C., Axthelm, M., Villasante, E. D., Weiss, W., Edlefsen, P. T., Picker, L. & Frueh, K., Jan 1 2019, In : PLoS One. 14, 1, e0210252.

Research output: Contribution to journalArticle

Plasmodium knowlesi
Cytomegalovirus
Sporozoites
T-cells
Parasitemia

Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome

GC6-74 Consortium, Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Tuberculosis
Metabolomics
Transfer RNA Aminoacylation
Metabolome
Transcriptome

Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Yee, J. A. L., Prongay, K., Miles, B., Smedley, J., Hansen, S., Axthelm, M., Ardeshir, A., Van Rompay, K. K. A., Timmel, G. & Roberts, J. A., Jan 1 2019, In : Journal of medical primatology.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis complex
Macaca mulatta
interferon-gamma
Mycobacterium tuberculosis
Primates
2018
3 Citations (Scopus)

Combination adenovirus and protein vaccines prevent infection or reduce viral burden after heterologous clade C simian-human immunodeficiency virus mucosal challenge

Malherbe, D., Mendy, J., Vang, L., Barnette, P. T., Reed, J., Lakhashe, S. K., Owuor, J., Gach, J. S., Legasse, A. W., Axthelm, M., LaBranche, C. C., Montefiori, D., Forthal, D. N., Park, B., Wilson, J. M., McLinden, J. H., Xiang, J., Stapleton, J. T., Sacha, J., Haynes, B. F. & 6 others, Liao, H. X., Ruprecht, R. M., Smith, J., Gurwith, M., Haigwood, N. & Alexander, J., Jan 1 2018, In : Journal of Virology. 92, 2, e01092-17.

Research output: Contribution to journalArticle

Adenovirus Vaccines
Combined Vaccines
Simian Immunodeficiency Virus
Human immunodeficiency virus
Macaca
3 Citations (Scopus)

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Okoye, A., Hansen, S., Vaidya, M., Fukazawa, Y., Park, H., Duell, D. M., Lum, R., Hughes, C. M., Ventura, A. B., Ainslie, E., Ford, J. C., Morrow, D., Gilbride, R. M., Legasse, A. W., Hesselgesser, J., Geleziunas, R., Li, Y., Oswald, K., Shoemaker, R., Fast, R. & 6 others, Bosche, W. J., Borate, B. R., Edlefsen, P. T., Axthelm, M., Picker, L. & Lifson, J. D., Sep 1 2018, In : Nature Medicine. 24, 9, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Secondary Prevention
Viruses
Cytomegalovirus
Macaca mulatta
4 Citations (Scopus)

Potent immune modulation by medi6383, an engineered human ox40 ligand igg4p fc fusion protein

Oberst, M. D., Auge, C., Morris, C., Kentner, S., Mulgrew, K., McGlinchey, K., Hair, J., Hanabuchi, S., Du, Q., Damschroder, M., Feng, H., Eck, S., Buss, N., de Haan, L., Pierce, A. J., Park, H., Sylwester, A., Axthelm, M., Picker, L., Morris, N. P. & 2 others, Weinberg, A. & Hammond, S. A., May 1 2018, In : Molecular Cancer Therapeutics. 17, 5, p. 1024-1038 15 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Proteins
Cell Proliferation
Neoplasms
Cytokines
41 Citations (Scopus)

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

Hansen, S., Zak, D. E., Xu, G., Ford, J. C., Marshall, E., Malouli, D., Gilbride, R. M., Hughes, C. M., Ventura, A. B., Ainslie, E., Randall, K. T., Selseth, A. N., Rundstrom, P., Herlache, L., Lewis, M. S., Park, H., Planer, S. L., Turner, J. M., Fischer, M., Armstrong, C. & 20 others, Zweig, R. C., Valvo, J., Braun, J. M., Shankar, S., Lu, L., Sylwester, A., Legasse, A. W., Messerle, M., Jarvis, M. A., Amon, L. M., Aderem, A., Alter, G., Laddy, D. J., Stone, M., Bonavia, A., Evans, T. G., Axthelm, M., Frueh, K., Edlefsen, P. T. & Picker, L., Feb 1 2018, In : Nature Medicine. 24, 2, p. 130-143 14 p.

Research output: Contribution to journalArticle

Cytomegalovirus Vaccines
Macaca mulatta
Tuberculosis
Vaccines
Tissue
9 Citations (Scopus)

The Role of MHC-E in T Cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques

Wu, H. L., Wiseman, R. W., Hughes, C. M., Webb, G. M., Abdulhaqq, S. A., Bimber, B. N., Hammond, K. B., Reed, J. S., Gao, L., Burwitz, B., Greene, J. M., Ferrer, F., Legasse, A. W., Axthelm, M., Park, B., Brackenridge, S., Maness, N. J., McMichael, A. J., Picker, L., O'Connor, D. H. & 2 others, Hansen, S. & Sacha, J., Jan 1 2018, In : Journal of Immunology. 200, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

Macaca
Macaca mulatta
Immunity
T-Lymphocytes
Peptides
26 Citations (Scopus)

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Hirsch, A., Roberts, V., Grigsby, P., Haese, N., Schabel, M., Wang, X., Lo, J., Liu, Z., Kroenke, C. C., Smith, J. L., Kelleher, M., Broeckel, R., Kreklywich, C. N., Parkins, C. J., Denton, M., Smith, P., De Filippis, V., Messer, W., Nelson, J., Hennebold, J. & 12 others, Grafe, M., Colgin, L., Lewis, A., Ducore, R., Swanson, T., Legasse, A. W., Axthelm, M., MacAllister, R., Moses, A., Morgan, T., Frias, A. & Streblow, D., Dec 1 2018, In : Nature Communications. 9, 1, 263.

Research output: Contribution to journalArticle

viruses
infectious diseases
Fetal Development
Macaca mulatta
Viruses
2017
2 Citations (Scopus)

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes

Burwitz, B., Wu, H. L., Abdulhaqq, S., Shriver-Munsch, C., Swanson, T., Legasse, A. W., Hammond, K. B., Junell, S. L., Reed, J. S., Bimber, B. N., Greene, J. M., Webb, G. M., Northrup, M., Laub, W., Kievit, P., MacAllister, R., Axthelm, M., Ducore, R., Lewis, A., Colgin, L. & 9 others, Hobbs, T., Martin, L. D., Ferguson, B., Thomas, C., Panoskaltsis-Mortari, A., Meyers, G., Stanton, J., Maziarz, R. & Sacha, J., Dec 1 2017, In : Nature Communications. 8, 1, 1418.

Research output: Contribution to journalArticle

transplantation
stem cells
Hematopoietic Stem Cell Transplantation
Macaca
Stem Cell Transplantation
27 Citations (Scopus)

MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates

Greene, J. M., Dash, P., Roy, S., McMurtrey, C., Awad, W., Reed, J. S., Hammond, K. B., Abdulhaqq, S., Wu, H. L., Burwitz, B., Roth, B. F., Morrow, D. W., Ford, J. C., Xu, G., Bae, J. Y., Crank, H., Legasse, A. W., Dang, T. H., Greenaway, H. Y., Kurniawan, M. & 14 others, Gold, M., Harriff, M., Lewinsohn, D., Park, B., Axthelm, M., Stanton, J., Hansen, S., Picker, L., Venturi, V., Hildebrand, W., Thomas, P. G., Lewinsohn, D., Adams, E. J. & Sacha, J., May 1 2017, In : Mucosal Immunology. 10, 3, p. 802-813 12 p.

Research output: Contribution to journalArticle

Primates
Macaca
Vaccination
Infection
Ligands
13 Citations (Scopus)

Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques

Broeckel, R., Fox, J. M., Haese, N., Kreklywich, C. N., Sukulpovi-Petty, S., Legasse, A., Smith, P. P., Denton, M., Corvey, C., Krishnan, S., Colgin, L., Ducore, R., Lewis, A., Axthelm, M., Mandron, M., Cortez, P., Rothblatt, J., Rao, E., Focken, I., Carter, K. & 4 others, Sapparapau, G., Crowe, J. E., Diamond, M. S. & Streblow, D., Jun 19 2017, In : PLoS Neglected Tropical Diseases. 11, 6, e0005637.

Research output: Contribution to journalArticle

Chikungunya virus
Virus Diseases
Macaca mulatta
Monoclonal Antibodies
Viral Load
91 Citations (Scopus)

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

Hirsch, A., Smith, J. L., Haese, N. N., Broeckel, R. M., Parkins, C. J., Kreklywich, C., De Filippis, V., Denton, M., Smith, P. P., Messer, W., Colgin, L., Ducore, R., Grigsby, P., Hennebold, J., Swanson, T., Legasse, A. W., Axthelm, M., MacAllister, R., Wiley, C. A., Nelson, J. & 1 others, Streblow, D., Mar 1 2017, In : PLoS Pathogens. 13, 3, e1006219.

Research output: Contribution to journalArticle

Macaca mulatta
Conjunctivitis
Exanthema
Fever
Joints
2016
105 Citations (Scopus)

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

Hansen, S., Wu, H. L., Burwitz, B., Hughes, C. M., Hammond, K. B., Ventura, A. B., Reed, J. S., Gilbride, R. M., Ainslie, E., Morrow, D. W., Ford, J. C., Selseth, A. N., Pathak, R., Malouli, D., Legasse, A. W., Axthelm, M., Nelson, J., Gillespie, G. M., Walters, L. C., Brackenridge, S. & 8 others, Sharpe, H. R., López, C. A., Frueh, K., Korber, B. T., McMichael, A. J., Gnanakaran, S., Sacha, J. & Picker, L., Feb 12 2016, In : Science. 351, 6274, p. 714-720 7 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
T-Lymphocytes
Natural Killer Cells
Epitopes
Immune Evasion
11 Citations (Scopus)

Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques

Burwitz, B., Malouli, D., Bimber, B. N., Reed, J. S., Ventura, A. B., Hancock, M., Uebelhoer, L. S., Bhusari, A., Hammond, K. B., Espinosa Trethewy, R. G., Klug, A., Legasse, A. W., Axthelm, M., Nelson, J., Park, B., Streblow, D., Hansen, S., Picker, L., Frueh, K. & Sacha, J., Nov 1 2016, In : PLoS Pathogens. 12, 11, e1006014.

Research output: Contribution to journalArticle

Cytomegalovirus Infections
Macaca
Cytomegalovirus
Primates
Tropism
63 Citations (Scopus)

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

Hessell, A., Jaworski, J. P., Epson, E., Matsuda, K., Pandey, S., Kahl, C., Reed, J., Sutton, W. F., Hammond, K. B., Cheever, T. A., Barnette, P. T., Legasse, A. W., Planer, S., Stanton, J., Pegu, A., Chen, X., Wang, K., Siess, D., Burke, D., Park, B. & 7 others, Axthelm, M., Lewis, A., Hirsch, V. M., Graham, B. S., Mascola, J. R., Sacha, J. & Haigwood, N., Apr 1 2016, In : Nature Medicine. 22, 4, p. 362-368 7 p.

Research output: Contribution to journalArticle

Macaca
Viruses
Neutralizing Antibodies
Monoclonal Antibodies
Tissue
12 Citations (Scopus)

Effect of anti-IL-15 administration on T Cell and NK cell homeostasis in rhesus macaques

Degottardi, M. Q., Okoye, A., Vaidya, M., Talla, A., Konfe, A. L., Reyes, M. D., Clock, J. A., Duell, D. M., Legasse, A. W., Sabnis, A., Park, B., Axthelm, M., Estes, J., Reiman, K. A., Sekaly, R. P. & Picker, L., Aug 15 2016, In : Journal of Immunology. 197, 4, p. 1183-1198 16 p.

Research output: Contribution to journalArticle

Interleukin-15
Macaca mulatta
Natural Killer Cells
Homeostasis
T-Lymphocytes
11 Citations (Scopus)

Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus

Sturgill, E. R., Malouli, D., Hansen, S., Burwitz, B., Seo, S., Schneider, C. L., Womack, J. L., Verweij, M., Ventura, A. B., Bhusari, A., Jeffries, K. M., Legasse, A. W., Axthelm, M., Hudson, A. W., Sacha, J., Picker, L. & Frueh, K., Aug 1 2016, In : PLoS Pathogens. 12, 8, e1005868.

Research output: Contribution to journalArticle

Cytomegalovirus Infections
Natural Killer Cells
Cytomegalovirus
Infection
Natural Killer Cell Receptors
2015
10 Citations (Scopus)

A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques

Vatter, H. A., Donaldson, E. F., Huynh, J., Rawlings, S., Manoharan, M., Legasse, A., Planer, S., Dickerson, M. F., Lewis, A., Colgin, L., Axthelm, M., Pecotte, J. K., Baric, R. S., Wong, S. & Brinton, M. A., Jan 1 2015, In : Virology. 474, p. 186-198 13 p.

Research output: Contribution to journalArticle

Arterivirus
Papio
Macaca
Fever
Viral Hemorrhagic Fevers
223 Citations (Scopus)

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

Fukazawa, Y., Lum, R., Okoye, A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., Morcock, D., Swanson, T., Legasse, A. W., Axthelm, M., Hesselgesser, J., Geleziunas, R., Hirsch, V. M., Edlefsen, P. T., Piatak, M., Estes, J. & 2 others, Lifson, J. D. & Picker, L., 2015, In : Nature Medicine. 21, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Viruses
B-Lymphocytes
T-cells
11 Citations (Scopus)

Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques

Okoye, A., Rohankhedkar, M., Konfe, A. L., Abana, C. O., Reyes, M. D., Clock, J. A., Duell, D. M., Sylwester, A., Sammader, P., Legasse, A. W., Park, B., Axthelm, M., Nikolich-Žugich, J. & Picker, L., Nov 1 2015, In : Journal of Immunology. 195, 9, p. 4292-4305 14 p.

Research output: Contribution to journalArticle

Interleukin-7
Macaca mulatta
Homeostasis
T-Lymphocytes
Therapeutics
2014
26 Citations (Scopus)

Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes

Pal, P., Fox, J. M., Hawman, D. W., Huang, Y. J. S., Messaoudi, I., Kreklywich, C., Denton, M., Legasse, A. W., Smith, P. P., Johnson, S., Axthelm, M., Vanlandingham, D. L., Streblow, D., Higgs, S., Morrison, T. E. & Diamond, M. S., 2014, In : Journal of Virology. 88, 15, p. 8213-8226 14 p.

Research output: Contribution to journalArticle

Chikungunya virus
Culicidae
monoclonal antibodies
Monoclonal Antibodies
neutralization
17 Citations (Scopus)

Cytomegalovirus pp65 limits dissemination but is dispensable for persistence

Malouli, D., Hansen, S., Nakayasu, E. S., Marshall, E., Hughes, C. M., Ventura, A. B., Gilbride, R. M., Lewis, M. S., Xu, G., Kreklywich, C., Whizin, N., Fischer, M., Legasse, A. W., Viswanathan, K., Siess, D., Camp, D. G., Axthelm, M., Kahl, C., De Filippis, V., Smith, R. D. & 3 others, Streblow, D., Picker, L. & Frueh, K., 2014, In : Journal of Clinical Investigation. 124, 5, p. 1928-1944 17 p.

Research output: Contribution to journalArticle

Phosphoproteins
Infection
T-Lymphocytes
Virion
Immunity
1 Citation (Scopus)

Erratum: Immune clearance of highly pathogenic SIV infection (Nature (2013) 502 (100-104) DOI:10.1038/nature12519))

Hansen, S., Piatak, M., Ventura, A. B., Hughes, C. M., Gilbride, R. M., Ford, J. C., Oswald, K., Shoemaker, R., Li, Y., Lewis, M. S., Gilliam, A. N., Xu, G., Whizin, N., Burwitz, B., Planer, S. L., Turner, J. M., Legasse, A. W., Axthelm, M., Nelson, J., Frueh, K. & 6 others, Sacha, J., Estes, J., Keele, B. F., Edlefsen, P. T., Lifson, J. D. & Picker, L., Oct 30 2014, In : Nature. 514, 7524, p. 654 1 p.

Research output: Contribution to journalArticle

Infection
5 Citations (Scopus)

Full genome sequence analysis of a novel adenovirus of rhesus macaque origin indicates a new simian adenovirus type and species

Malouli, D., Howell, G. L., Legasse, A. W., Kahl, C., Axthelm, M., Hansen, S. & Frueh, K., Sep 1 2014, In : Virology Reports. 3, p. 18-29 12 p.

Research output: Contribution to journalArticle

Simian Adenoviruses
Macaca mulatta
Adenoviridae
Sequence Analysis
Genes
20 Citations (Scopus)

Pathophysiologic and Transcriptomic Analyses of Viscerotropic Yellow Fever in a Rhesus Macaque Model

Engelmann, F., Josset, L., Girke, T., Park, B., Barron, A., Dewane, J., Hammarlund, E., Lewis, A., Axthelm, M., Slifka, M. & Messaoudi, I., 2014, In : PLoS Neglected Tropical Diseases. 8, 11

Research output: Contribution to journalArticle

Yellow fever virus
Yellow Fever
Macaca mulatta
Virus Diseases
Infection
11 Citations (Scopus)

T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence

Alzhanova, D., Hammarlund, E., Reed, J., Meermeier, E., Rawlings, S., Ray, C. A., Edwards, D. M., Bimber, B., Legasse, A., Planer, S., Sprague, J., Axthelm, M., Pickup, D. J., Lewinsohn, D., Gold, M., Wong, S., Sacha, J., Slifka, M. & Frueh, K., 2014, In : PLoS Pathogens. 10, 5, e1004123.

Research output: Contribution to journalArticle

Viral Proteins
Virulence
T-Lymphocytes
Viremia
Monkeypox virus
11 Citations (Scopus)

The rhesus rhadinovirus CD200 homologue affects immune responses and viral loads during in vivo infection

Estep, R., Rawlings, S. D., Li, H., Manoharan, M., Blaine, E. T., O'Connor, M. A., Messaoudi, I., Axthelm, M. & Wong, S., 2014, In : Journal of Virology. 88, 18, p. 10635-10654 20 p.

Research output: Contribution to journalArticle

Macacine herpesvirus 5
Rhadinovirus
viral load
Macaca mulatta
Viral Load
2013
243 Citations (Scopus)

Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms

Hansen, S., Sacha, J., Hughes, C. M., Ford, J. C., Burwitz, B., Scholz, I., Gilbride, R. M., Lewis, M. S., Gilliam, A. N., Ventura, A. B., Malouli, D., Xu, G., Richards, R., Whizin, N., Reed, J. S., Hammond, K. B., Fischer, M., Turner, J. M., Legasse, A. W., Axthelm, M. & 5 others, Edlefsen, P. T., Nelson, J., Lifson, J. D., Frueh, K. & Picker, L., 2013, In : Science. 340, 6135, 1237874.

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Cytomegalovirus
Simian Immunodeficiency Virus
T-Lymphocytes
Epitopes
7 Citations (Scopus)
Rhadinovirus
Macaca fuscata
Herpesviridae
Macaca
Demyelinating Diseases
320 Citations (Scopus)

Immune clearance of highly pathogenic SIV infection

Hansen, S., Jr, M. P., Ventura, A. B., Hughes, C. M., Gilbride, R. M., Ford, J. C., Oswald, K., Shoemaker, R., Li, Y., Lewis, M. S., Gilliam, A. N., Xu, G., Whizin, N., Burwitz, B., Planer, S. L., Turner, J. M., Legasse, A. W., Axthelm, M., Nelson, J., Frueh, K. & 6 others, Sacha, J., Estes, J., Keele, B. F., Edlefsen, P. T., Lifson, J. D. & Picker, L., 2013, In : Nature. 502, 7469, p. 100-104 5 p.

Research output: Contribution to journalArticle

HIV
Infection
Macaca mulatta
Cytomegalovirus
T-Lymphocytes
11 Citations (Scopus)

Neisseria infection of rhesus macaques as a model to study colonization, transmission, persistence, and horizontal gene transfer

Weyand, N. J., Wertheimer, A. M., Hobbs, T., Sisko, J. L., Taku, N. A., Gregston, L. D., Clary, S., Higashi, D. L., Biais, N., Brown, L. M., Planer, S. L., Legasse, A. W., Axthelm, M., Wong, S. & So, M., Feb 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8, p. 3059-3064 6 p.

Research output: Contribution to journalArticle

Neisseria
Horizontal Gene Transfer
Macaca mulatta
Infection
Vaccines
22 Citations (Scopus)

Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques

Jaworski, J. P., Kobie, J., Brower, Z., Malherbe, D., Landucci, G., Sutton, W. F., Guo, B., Reed, J. S., Leon, E. J., Engelmann, F., Zheng, B., Legasse, A., Park, B., Dickerson, M., Lewis, A., Colgin, L., Axthelm, M., Messaoudi, I., Sacha, J., Burton, D. R. & 3 others, Forthal, D. N., Hessell, A. & Haigwood, N., 2013, In : Journal of Virology. 87, 19, p. 10447-10459 13 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Human immunodeficiency virus
Macaca mulatta
neutralization
Viremia
35 Citations (Scopus)

Polyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV gag protein-induced t cell responses in nonhuman primates

Park, H., Adamson, L., Ha, T., Mullen, K., Hagen, S. I., Nogueron, A., Sylwester, A., Axthelm, M., Legasse, A., Piatak, M., Lifson, J. D., McElrath, J. M., Picker, L. & Seder, R. A., Apr 15 2013, In : Journal of Immunology. 190, 8, p. 4103-4115 13 p.

Research output: Contribution to journalArticle

gag Gene Products
Poly I-C
Primates
T-Lymphocytes
Macaca mulatta
2012
99 Citations (Scopus)

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

Fukazawa, Y., Park, H., Cameron, M. J., Lefebvre, F., Lum, R., Coombes, N., Mahyari, E., Hagen, S. I., Bae, J. Y., Reyes, M. D., Swanson, T., Legasse, A. W., Sylwester, A., Hansen, S., Smith, A. T., Stafova, P., Shoemaker, R., Li, Y., Oswald, K., Axthelm, M. & 8 others, McDermott, A., Ferrari, G., Montefiori, D. C., Edlefsen, P. T., Piatak, M., Lifson, J. D., Sékaly, R. P. & Picker, L., Nov 2012, In : Nature Medicine. 18, 11, p. 1673-1681 9 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
T-cells
Viruses
Vaccines
Lymph Nodes
17 Citations (Scopus)

Naive T cells are dispensable for memory CD4 + T cell homeostasis in progressive simian immunodeficiency virus infection

Okoye, A., Rohankhedkar, M., Abana, C., Pattenn, A., Reyes, M., Pexton, C., Lum, R., Sylwester, A., Planer, S. L., Legasse, A., Park, B., Piatak, M., Lifson, J. D., Axthelm, M. & Picker, L., Apr 9 2012, In : Journal of Experimental Medicine. 209, 4, p. 641-651 11 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Homeostasis
T-Lymphocytes
Disease Progression
12 Citations (Scopus)

Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection

Robinson, B. A., O'connor, M. A., Li, H., Engelmann, F., Poland, B., Grant, R., De Filippis, V., Estep, R., Axthelm, M., Messaoudi, I. & Wong, S., Mar 2012, In : Journal of Virology. 86, 5, p. 2769-2779 11 p.

Research output: Contribution to journalArticle

Rhadinovirus
Macaca mulatta
immune response
Infection
infection
2011
44 Citations (Scopus)

Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques

Čičin-Šain, L., Sylwester, A., Hagen, S. I., Siess, D. C., Currier, N., Legasse, A. W., Fischer, M. B., Koudelka, C. W., Axthelm, M., Nikolich-Žugich, J. & Picker, L., Aug 15 2011, In : Journal of Immunology. 187, 4, p. 1722-1732 11 p.

Research output: Contribution to journalArticle

Macaca mulatta
Cytomegalovirus
Immunity
T-Lymphocytes
Population Control
14 Citations (Scopus)

Deletion of the monkeypox virus inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a nonhuman primate model of infection

Estep, R., Messaoudi, I., O'Connor, M. A., Li, H., Sprague, J., Barron, A., Engelmann, F., Yen, B., Powers, M. F., Jones, J. M., Robinson, B. A., Orzechowska, B. U., Manoharan, M., Legasse, A., Planer, S., Wilk, J., Axthelm, M. & Wong, S., Sep 2011, In : Journal of Virology. 85, 18, p. 9527-9542 16 p.

Research output: Contribution to journalArticle

Complement Inactivating Agents
Monkeypox virus
Adaptive Immunity
Enzyme Inhibitors
Primates
28 Citations (Scopus)

Japanese macaque encephalomyelitis: A spontaneous multiple sclerosis-like disease in a nonhuman primate

Axthelm, M., Bourdette, D., Marracci, G., Su, W., Mullaney, E. T., Manoharan, M., Kohama, S., Pollaro, J., Witkowski, E., Wang, P., Rooney, W., Sherman, L. L. & Wong, S., Sep 2011, In : Annals of Neurology. 70, 3, p. 362-373 12 p.

Research output: Contribution to journalArticle

Encephalomyelitis
Macaca
Primates
Multiple Sclerosis
Demyelinating Diseases
626 Citations (Scopus)

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

Hansen, S., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., Whizin, N., Oswald, K., Shoemaker, R., Swanson, T., Legasse, A. W., Chiuchiolo, M. J., Parks, C. L., Axthelm, M., Nelson, J., Jarvis, M. A., Piatak, M., Lifson, J. D. & Picker, L., May 26 2011, In : Nature. 473, 7348, p. 523-527 5 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Vaccines
T-Lymphocytes
Cytomegalovirus
Macaca mulatta
2010
167 Citations (Scopus)

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

Hansen, S., Powers, C. J., Richards, R., Ventura, A. B., Ford, J. C., Siess, D., Axthelm, M., Nelson, J., Jarvis, M. A., Picker, L. & Frueh, K., Apr 2 2010, In : Science. 328, 5974, p. 102-106 5 p.

Research output: Contribution to journalArticle

Superinfection
Cytomegalovirus
T-Lymphocytes
Macaca mulatta
Major Histocompatibility Complex
14 Citations (Scopus)

Immune response to the West Nile virus in aged non- human primates

Wertheimer, A. M., Uhrlaub, J. L., Hirsch, A., Medigeshi, G., Sprague, J., Legasse, A., Wilk, J., Wiley, C. A., Didier, P., Tesh, R. B., Murray, K. O., Axthelm, M., Wong, S. & Nikolich-Žugich, J., 2010, In : PLoS One. 5, 12, e15514.

Research output: Contribution to journalArticle

West Nile virus
Viruses
Primates
immune response
Macaca
26 Citations (Scopus)

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses

Leone, A., Rohankhedkar, M., Okoye, A., Legasse, A., Axthelm, M., Villinger, F., Piatak, M., Lifson, J. D., Assouline, B., Morre, M., Picker, L. & Sodora, D. L., Aug 1 2010, In : Journal of Immunology. 185, 3, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

Interleukin-7
Simian Immunodeficiency Virus
Macaca
T-Lymphocytes
Therapeutics
74 Citations (Scopus)

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates

Čičin-Šain, L., Smyk-Paerson, S., Currier, N., Byrd, L., Koudelka, C., Robinson, T., Swarbrick, G., Tackitt, S., Legasse, A., Fischer, M., Nikolich-Žugich, D., Park, B., Hobbs, T., Doane, C. J., Mori, M. T., Axthelm, M., Lewinsohn, D. & Nikolich-Žugich, J., Jun 15 2010, In : Journal of Immunology. 184, 12, p. 6739-6745 7 p.

Research output: Contribution to journalArticle

Constriction
Primates
Vaccination
T-Lymphocytes
Haplorhini

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates (J. Immunol. (2010) 184 (6739-6745))

Čicin-Šain, L., Smyk-Paerson, S., Currier, N., Byrd, L., Koudelka, C., Robinson, T., Swarbrick, G., Tackitt, S., Legasse, A., Fischer, M., Nikolich-Žugich, D., Park, B., Hobbs, T., Doane, C. J., Mori, M. T., Axthelm, M., Lewinsohn, D. & Nikolich-Žugich., J., Oct 1 2010, In : Journal of Immunology. 185, 7, p. 4509 1 p.

Research output: Contribution to journalArticle

Constriction
Primates
Vaccination
T-Lymphocytes
2009
493 Citations (Scopus)

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

Hansen, S., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J., Jarvis, M. A. & Picker, L., Mar 2009, In : Nature Medicine. 15, 3, p. 293-299 7 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
T-cells
Macaca mulatta
Viruses
Cytomegalovirus
1 Citation (Scopus)

Erratum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge (Nature Medicine (2009) 15 (293-299))

Hansen, S., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J., Jarvis, M. A. & Picker, L., Apr 2009, In : Nature Medicine. 15, 4, p. 462 1 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Macaca mulatta
Medicine
T-Lymphocytes
54 Citations (Scopus)

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

Okoye, A., Park, H., Rohankhedkar, M., Coyne-Johnson, L., Lum, R., Walker, J. M., Planer, S. L., Legasse, A. W., Sylwester, A., Piatak, M., Lifson, J. D., Sodora, D. L., Villinger, F., Axthelm, M., Schmitz, J. E. & Picker, L., Jul 6 2009, In : Journal of Experimental Medicine. 206, 7, p. 1575-1588 14 p.

Research output: Contribution to journalArticle

Lymphocyte Depletion
Simian Immunodeficiency Virus
T-Lymphocytes
Virus Diseases
Macaca mulatta
105 Citations (Scopus)

Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques

Novy, M. J., Duffy, L., Axthelm, M., Sadowsky, D. W., Witkin, S. S., Gravett, M. G., Cassell, G. H. & Waites, K. B., Jan 2009, In : Reproductive Sciences. 16, 1, p. 56-70 15 p.

Research output: Contribution to journalArticle

Mycoplasma hominis
Ureaplasma
Chorioamnionitis
Amniotic Fluid
Macaca mulatta