Michael Axthelm

Associate Scientist

  • 7192 Citations
  • 41 h-Index
1978 …2020

Research output per year

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Research Output

  • 7192 Citations
  • 41 h-Index
  • 123 Article
  • 8 Comment/debate
  • 1 Review article
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Article
2019

Cytomegalovirus vectors expressing Plasmodium knowlesi antigens induce immune responses that delay parasitemia upon sporozoite challenge

Hansen, S., Womack, J., Scholz, I., Renner, A., Edgel, K. A., Xu, G., Ford, J. C., Grey, M., St. Laurent, B., Turner, J. M., Planer, S., Legasse, A. W., Richie, T. L., Aguiar, J. C., Axthelm, M., Villasante, E. D., Weiss, W., Edlefsen, P. T., Picker, L. & Frueh, K., Jan 1 2019, In : PLoS One. 14, 1, e0210252.

Research output: Contribution to journalArticle

9 Scopus citations

Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Marshall, E., Malouli, D., Hansen, S., Gilbride, R. M., Hughes, C. M., Ventura, A. B., Ainslie, E., Selseth, A. N., Ford, J. C., Burke, D., Kreklywich, C. N., Womack, J., Legasse, A. W., Axthelm, M., Kahl, C., Streblow, D., Edlefsen, P. T., Picker, L. & Frueh, K., Jul 17 2019, In : Science Translational Medicine. 11, 501, eaaw2603.

Research output: Contribution to journalArticle

5 Scopus citations

Immunometabolic signatures predict risk of progression to active tuberculosis and disease outcome

GC6-74 Consortium, Jan 1 2019, In : Frontiers in immunology. 10, MAR, 527.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Yee, J. A. L., Prongay, K., Miles, B., Smedley, J., Hansen, S. G., Axthelm, M. K., Ardeshir, A., Van Rompay, K. K. A., Timmel, G. & Roberts, J. A., Aug 2019, In : Journal of medical primatology. 48, 4, p. 260-263 4 p.

Research output: Contribution to journalArticle

Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+ T Cells in Nonhuman Primates

Abdulhaqq, S. A., Wu, H., Schell, J. B., Hammond, K. B., Reed, J. S., Legasse, A. W., Axthelm, M. K., Park, B. S., Asokan, A., Früh, K., Hansen, S. G., Picker, L. J. & Sacha, J. B., Oct 1 2019, In : Journal of virology. 93, 19

Research output: Contribution to journalArticle

1 Scopus citations
2018

Combination adenovirus and protein vaccines prevent infection or reduce viral burden after heterologous clade C simian-human immunodeficiency virus mucosal challenge

Malherbe, D. C., Mendy, J., Vang, L., Barnette, P. T., Reed, J., Lakhashe, S. K., Owuor, J., Gach, J. S., Legasse, A. W., Axthelm, M. K., LaBranche, C. C., Montefiori, D., Forthal, D. N., Park, B., Wilson, J. M., McLinden, J. H., Xiang, J., Stapleton, J. T., Sacha, J. B., Haynes, B. F. & 6 others, Liao, H. X., Ruprecht, R. M., Smith, J., Gurwith, M., Haigwood, N. L. & Alexander, J., Jan 1 2018, In : Journal of virology. 92, 2, e01092-17.

Research output: Contribution to journalArticle

10 Scopus citations

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Okoye, A. A., Hansen, S. G., Vaidya, M., Fukazawa, Y., Park, H., Duell, D. M., Lum, R., Hughes, C. M., Ventura, A. B., Ainslie, E., Ford, J. C., Morrow, D., Gilbride, R. M., Legasse, A. W., Hesselgesser, J., Geleziunas, R., Li, Y., Oswald, K., Shoemaker, R., Fast, R. & 6 others, Bosche, W. J., Borate, B. R., Edlefsen, P. T., Axthelm, M. K., Picker, L. J. & Lifson, J. D., Sep 1 2018, In : Nature medicine. 24, 9, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Potent immune modulation by medi6383, an engineered human ox40 ligand igg4p fc fusion protein

Oberst, M. D., Auge, C., Morris, C., Kentner, S., Mulgrew, K., McGlinchey, K., Hair, J., Hanabuchi, S., Du, Q., Damschroder, M., Feng, H., Eck, S., Buss, N., de Haan, L., Pierce, A. J., Park, H., Sylwester, A., Axthelm, M., Picker, L., Morris, N. P. & 2 others, Weinberg, A. & Hammond, S. A., May 1 2018, In : Molecular Cancer Therapeutics. 17, 5, p. 1024-1038 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

Hansen, S. G., Zak, D. E., Xu, G., Ford, J. C., Marshall, E. E., Malouli, D., Gilbride, R. M., Hughes, C. M., Ventura, A. B., Ainslie, E., Randall, K. T., Selseth, A. N., Rundstrom, P., Herlache, L., Lewis, M. S., Park, H., Planer, S. L., Turner, J. M., Fischer, M., Armstrong, C. & 20 others, Zweig, R. C., Valvo, J., Braun, J. M., Shankar, S., Lu, L., Sylwester, A. W., Legasse, A. W., Messerle, M., Jarvis, M. A., Amon, L. M., Aderem, A., Alter, G., Laddy, D. J., Stone, M., Bonavia, A., Evans, T. G., Axthelm, M. K., Früh, K., Edlefsen, P. T. & Picker, L. J., Feb 1 2018, In : Nature medicine. 24, 2, p. 130-143 14 p.

Research output: Contribution to journalArticle

70 Scopus citations

The Role of MHC-E in T Cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques

Wu, H. L., Wiseman, R. W., Hughes, C. M., Webb, G. M., Abdulhaqq, S. A., Bimber, B. N., Hammond, K. B., Reed, J. S., Gao, L., Burwitz, B. J., Greene, J. M., Ferrer, F., Legasse, A. W., Axthelm, M. K., Park, B. S., Brackenridge, S., Maness, N. J., McMichael, A. J., Picker, L. J., O'Connor, D. H. & 2 others, Hansen, S. G. & Sacha, J. B., Jan 1 2018, In : Journal of Immunology. 200, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Hirsch, A. J., Roberts, V. H. J., Grigsby, P. L., Haese, N., Schabel, M. C., Wang, X., Lo, J. O., Liu, Z., Kroenke, C. D., Smith, J. L., Kelleher, M., Broeckel, R., Kreklywich, C. N., Parkins, C. J., Denton, M., Smith, P., Defilippis, V., Messer, W., Nelson, J. A., Hennebold, J. D. & 12 others, Grafe, M., Colgin, L., Lewis, A., Ducore, R., Swanson, T., Legasse, A. W., Axthelm, M. K., MacAllister, R., Moses, A. V., Morgan, T. K., Frias, A. E. & Streblow, D. N., Dec 1 2018, In : Nature Communications. 9, 1, 263.

Research output: Contribution to journalArticle

50 Scopus citations
2017

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes

Burwitz, B., Wu, H. L., Abdulhaqq, S., Shriver-Munsch, C., Swanson, T., Legasse, A. W., Hammond, K. B., Junell, S. L., Reed, J. S., Bimber, B. N., Greene, J. M., Webb, G. M., Northrup, M., Laub, W., Kievit, P., MacAllister, R., Axthelm, M., Ducore, R., Lewis, A., Colgin, L. & 9 others, Hobbs, T., Martin, L. D., Ferguson, B., Thomas, C., Panoskaltsis-Mortari, A., Meyers, G., Stanton, J., Maziarz, R. & Sacha, J., Dec 1 2017, In : Nature Communications. 8, 1, 1418.

Research output: Contribution to journalArticle

4 Scopus citations

MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates

Greene, J. M., Dash, P., Roy, S., McMurtrey, C., Awad, W., Reed, J. S., Hammond, K. B., Abdulhaqq, S., Wu, H. L., Burwitz, B., Roth, B. F., Morrow, D. W., Ford, J. C., Xu, G., Bae, J. Y., Crank, H., Legasse, A. W., Dang, T. H., Greenaway, H. Y., Kurniawan, M. & 14 others, Gold, M., Harriff, M., Lewinsohn, D., Park, B., Axthelm, M., Stanton, J., Hansen, S., Picker, L., Venturi, V., Hildebrand, W., Thomas, P. G., Lewinsohn, D., Adams, E. J. & Sacha, J., May 1 2017, In : Mucosal Immunology. 10, 3, p. 802-813 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques

Broeckel, R., Fox, J. M., Haese, N., Kreklywich, C. N., Sukulpovi-Petty, S., Legasse, A., Smith, P. P., Denton, M., Corvey, C., Krishnan, S., Colgin, L., Ducore, R., Lewis, A., Axthelm, M., Mandron, M., Cortez, P., Rothblatt, J., Rao, E., Focken, I., Carter, K. & 4 others, Sapparapau, G., Crowe, J. E., Diamond, M. S. & Streblow, D., Jun 19 2017, In : PLoS Neglected Tropical Diseases. 11, 6, e0005637.

Research output: Contribution to journalArticle

21 Scopus citations

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

Hirsch, A., Smith, J. L., Haese, N. N., Broeckel, R. M., Parkins, C. J., Kreklywich, C., De Filippis, V., Denton, M., Smith, P. P., Messer, W., Colgin, L., Ducore, R., Grigsby, P., Hennebold, J., Swanson, T., Legasse, A. W., Axthelm, M., MacAllister, R., Wiley, C. A., Nelson, J. & 1 others, Streblow, D., Mar 1 2017, In : PLoS Pathogens. 13, 3, e1006219.

Research output: Contribution to journalArticle

111 Scopus citations
2016

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

Hansen, S., Wu, H. L., Burwitz, B., Hughes, C. M., Hammond, K. B., Ventura, A. B., Reed, J. S., Gilbride, R. M., Ainslie, E., Morrow, D. W., Ford, J. C., Selseth, A. N., Pathak, R., Malouli, D., Legasse, A. W., Axthelm, M., Nelson, J., Gillespie, G. M., Walters, L. C., Brackenridge, S. & 8 others, Sharpe, H. R., López, C. A., Frueh, K., Korber, B. T., McMichael, A. J., Gnanakaran, S., Sacha, J. & Picker, L., Feb 12 2016, In : Science. 351, 6274, p. 714-720 7 p.

Research output: Contribution to journalArticle

135 Scopus citations

Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques

Burwitz, B., Malouli, D., Bimber, B. N., Reed, J. S., Ventura, A. B., Hancock, M., Uebelhoer, L. S., Bhusari, A., Hammond, K. B., Espinosa Trethewy, R. G., Klug, A., Legasse, A. W., Axthelm, M., Nelson, J., Park, B., Streblow, D., Hansen, S., Picker, L., Frueh, K. & Sacha, J., Nov 1 2016, In : PLoS Pathogens. 12, 11, e1006014.

Research output: Contribution to journalArticle

15 Scopus citations

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

Hessell, A., Jaworski, J. P., Epson, E., Matsuda, K., Pandey, S., Kahl, C., Reed, J., Sutton, W. F., Hammond, K. B., Cheever, T. A., Barnette, P. T., Legasse, A. W., Planer, S., Stanton, J., Pegu, A., Chen, X., Wang, K., Siess, D., Burke, D., Park, B. & 7 others, Axthelm, M., Lewis, A., Hirsch, V. M., Graham, B. S., Mascola, J. R., Sacha, J. & Haigwood, N., Apr 1 2016, In : Nature Medicine. 22, 4, p. 362-368 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

Effect of anti-IL-15 administration on T Cell and NK cell homeostasis in rhesus macaques

Degottardi, M. Q., Okoye, A., Vaidya, M., Talla, A., Konfe, A. L., Reyes, M. D., Clock, J. A., Duell, D. M., Legasse, A. W., Sabnis, A., Park, B., Axthelm, M., Estes, J., Reiman, K. A., Sekaly, R. P. & Picker, L., Aug 15 2016, In : Journal of Immunology. 197, 4, p. 1183-1198 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus

Sturgill, E. R., Malouli, D., Hansen, S., Burwitz, B., Seo, S., Schneider, C. L., Womack, J. L., Verweij, M., Ventura, A. B., Bhusari, A., Jeffries, K. M., Legasse, A. W., Axthelm, M., Hudson, A. W., Sacha, J., Picker, L. & Frueh, K., Aug 1 2016, In : PLoS Pathogens. 12, 8, e1005868.

Research output: Contribution to journalArticle

16 Scopus citations
2015

A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques

Vatter, H. A., Donaldson, E. F., Huynh, J., Rawlings, S., Manoharan, M., Legasse, A., Planer, S., Dickerson, M. F., Lewis, A. D., Colgin, L. M. A., Axthelm, M. K., Pecotte, J. K., Baric, R. S., Wong, S. W. & Brinton, M. A., Jan 1 2015, In : Virology. 474, p. 186-198 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

Fukazawa, Y., Lum, R., Okoye, A. A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., Morcock, D., Swanson, T., Legasse, A. W., Axthelm, M. K., Hesselgesser, J., Geleziunas, R., Hirsch, V. M., Edlefsen, P. T., Piatak, M., Estes, J. D. & 2 others, Lifson, J. D. & Picker, L. J., Feb 2015, In : Nature medicine. 21, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

267 Scopus citations

Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques

Okoye, A. A., Rohankhedkar, M., Konfe, A. L., Abana, C. O., Reyes, M. D., Clock, J. A., Duell, D. M., Sylwester, A. W., Sammader, P., Legasse, A. W., Park, B. S., Axthelm, M. K., Nikolich-Žugich, J. & Picker, L. J., Nov 2015, In : Journal of Immunology. 195, 9, p. 4292-4305 14 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes

Pal, P., Fox, J. M., Hawman, D. W., Huang, Y. J. S., Messaoudi, I., Kreklywich, C., Denton, M., Legasse, A. W., Smith, P. P., Johnson, S., Axthelm, M. K., Vanlandingham, D. L., Streblow, D. N., Higgs, S., Morrison, T. E. & Diamond, M. S., 2014, In : Journal of virology. 88, 15, p. 8213-8226 14 p.

Research output: Contribution to journalArticle

34 Scopus citations

Cytomegalovirus pp65 limits dissemination but is dispensable for persistence

Malouli, D., Hansen, S. G., Nakayasu, E. S., Marshall, E. E., Hughes, C. M., Ventura, A. B., Gilbride, R. M., Lewis, M. S., Xu, G., Kreklywich, C., Whizin, N., Fischer, M., Legasse, A. W., Viswanathan, K., Siess, D., Camp, D. G., Axthelm, M. K., Kahl, C., DeFilippis, V. R., Smith, R. D. & 3 others, Streblow, D. N., Picker, L. J. & Früh, K., 2014, In : Journal of Clinical Investigation. 124, 5, p. 1928-1944 17 p.

Research output: Contribution to journalArticle

19 Scopus citations

Full genome sequence analysis of a novel adenovirus of rhesus macaque origin indicates a new simian adenovirus type and species

Malouli, D., Howell, G. L., Legasse, A. W., Kahl, C., Axthelm, M. K., Hansen, S. G. & Früh, K., Sep 1 2014, In : Virology Reports. 3, p. 18-29 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pathophysiologic and Transcriptomic Analyses of Viscerotropic Yellow Fever in a Rhesus Macaque Model

Engelmann, F., Josset, L., Girke, T., Park, B., Barron, A., Dewane, J., Hammarlund, E., Lewis, A., Axthelm, M. K., Slifka, M. K. & Messaoudi, I., Jan 1 2014, In : PLoS neglected tropical diseases. 8, 11

Research output: Contribution to journalArticle

26 Scopus citations

T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence

Alzhanova, D., Hammarlund, E., Reed, J., Meermeier, E., Rawlings, S., Ray, C. A., Edwards, D. M., Bimber, B., Legasse, A., Planer, S., Sprague, J., Axthelm, M. K., Pickup, D. J., Lewinsohn, D. M., Gold, M. C., Wong, S. W., Sacha, J. B., Slifka, M. K. & Früh, K., May 2014, In : PLoS pathogens. 10, 5, e1004123.

Research output: Contribution to journalArticle

14 Scopus citations

The rhesus rhadinovirus CD200 homologue affects immune responses and viral loads during in vivo infection

Estep, R. D., Rawlings, S. D., Li, H., Manoharan, M., Blaine, E. T., O'Connor, M. A., Messaoudi, I., Axthelm, M. K. & Wong, S. W., 2014, In : Journal of virology. 88, 18, p. 10635-10654 20 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013
10 Scopus citations

Immune clearance of highly pathogenic SIV infection

Hansen, S. G., Jr, M. P., Ventura, A. B., Hughes, C. M., Gilbride, R. M., Ford, J. C., Oswald, K., Shoemaker, R., Li, Y., Lewis, M. S., Gilliam, A. N., Xu, G., Whizin, N., Burwitz, B. J., Planer, S. L., Turner, J. M., Legasse, A. W., Axthelm, M. K., Nelson, J. A., Früh, K. & 6 others, Sacha, J. B., Estes, J. D., Keele, B. F., Edlefsen, P. T., Lifson, J. D. & Picker, L. J., Jan 1 2013, In : Nature. 502, 7469, p. 100-104 5 p.

Research output: Contribution to journalArticle

355 Scopus citations

Neisseria infection of rhesus macaques as a model to study colonization, transmission, persistence, and horizontal gene transfer

Weyand, N. J., Wertheimer, A. M., Hobbs, T. R., Sisko, J. L., Taku, N. A., Gregston, L. D., Clary, S., Higashi, D. L., Biais, N., Brown, L. M., Planer, S. L., Legasse, A. W., Axthelm, M. K., Wong, S. W. & So, M., Feb 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8, p. 3059-3064 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques

Jaworski, J. P., Kobie, J., Brower, Z., Malherbe, D. C., Landucci, G., Sutton, W. F., Guo, B., Reed, J. S., Leon, E. J., Engelmann, F., Zheng, B., Legasse, A., Park, B., Dickerson, M., Lewis, A. D., Colgin, L. M. A., Axthelm, M., Messaoudi, I., Sacha, J. B., Burton, D. R. & 3 others, Forthal, D. N., Hessell, A. J. & Haigwood, N. L., Oct 28 2013, In : Journal of virology. 87, 19, p. 10447-10459 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Polyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV gag protein-induced t cell responses in nonhuman primates

Park, H., Adamson, L., Ha, T., Mullen, K., Hagen, S. I., Nogueron, A., Sylwester, A. W., Axthelm, M. K., Legasse, A., Piatak, M., Lifson, J. D., McElrath, J. M., Picker, L. J. & Seder, R. A., Apr 15 2013, In : Journal of Immunology. 190, 8, p. 4103-4115 13 p.

Research output: Contribution to journalArticle

39 Scopus citations
2012

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

Fukazawa, Y., Park, H., Cameron, M. J., Lefebvre, F., Lum, R., Coombes, N., Mahyari, E., Hagen, S. I., Bae, J. Y., Reyes, M. D., Swanson, T., Legasse, A. W., Sylwester, A., Hansen, S. G., Smith, A. T., Stafova, P., Shoemaker, R., Li, Y., Oswald, K., Axthelm, M. K. & 8 others, McDermott, A., Ferrari, G., Montefiori, D. C., Edlefsen, P. T., Piatak, M., Lifson, J. D., Sékaly, R. P. & Picker, L. J., Nov 1 2012, In : Nature medicine. 18, 11, p. 1673-1681 9 p.

Research output: Contribution to journalArticle

104 Scopus citations

Naive T cells are dispensable for memory CD4 + T cell homeostasis in progressive simian immunodeficiency virus infection

Okoye, A. A., Rohankhedkar, M., Abana, C., Pattenn, A., Reyes, M., Pexton, C., Lum, R., Sylwester, A., Planer, S. L., Legasse, A., Park, B. S., Piatak, M., Lifson, J. D., Axthelm, M. K. & Picker, L. J., Apr 9 2012, In : Journal of Experimental Medicine. 209, 4, p. 641-651 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection

Robinson, B. A., O'connor, M. A., Li, H., Engelmann, F., Poland, B., Grant, R., Defilippis, V., Estep, R. D., Axthelm, M. K., Messaoudi, I. & Wong, S. W., Mar 1 2012, In : Journal of virology. 86, 5, p. 2769-2779 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2011

Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques

Čičin-Šain, L., Sylwester, A. W., Hagen, S. I., Siess, D. C., Currier, N., Legasse, A. W., Fischer, M. B., Koudelka, C. W., Axthelm, M. K., Nikolich-Žugich, J. & Picker, L. J., Aug 15 2011, In : Journal of Immunology. 187, 4, p. 1722-1732 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Deletion of the monkeypox virus inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a nonhuman primate model of infection

Estep, R. D., Messaoudi, I., O'Connor, M. A., Li, H., Sprague, J., Barron, A., Engelmann, F., Yen, B., Powers, M. F., Jones, J. M., Robinson, B. A., Orzechowska, B. U., Manoharan, M., Legasse, A., Planer, S., Wilk, J., Axthelm, M. K. & Wong, S. W., Sep 1 2011, In : Journal of virology. 85, 18, p. 9527-9542 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Japanese macaque encephalomyelitis: A spontaneous multiple sclerosis-like disease in a nonhuman primate

Axthelm, M. K., Bourdette, D. N., Marracci, G. H., Su, W., Mullaney, E. T., Manoharan, M., Kohama, S. G., Pollaro, J., Witkowski, E., Wang, P., Rooney, W. D., Sherman, L. S. & Wong, S. W., Sep 1 2011, In : Annals of Neurology. 70, 3, p. 362-373 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

Hansen, S. G., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., Whizin, N., Oswald, K., Shoemaker, R., Swanson, T., Legasse, A. W., Chiuchiolo, M. J., Parks, C. L., Axthelm, M. K., Nelson, J. A., Jarvis, M. A., Piatak, M., Lifson, J. D. & Picker, L. J., May 26 2011, In : Nature. 473, 7348, p. 523-527 5 p.

Research output: Contribution to journalArticle

670 Scopus citations
2010

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

Hansen, S. G., Powers, C. J., Richards, R., Ventura, A. B., Ford, J. C., Siess, D., Axthelm, M. K., Nelson, J. A., Jarvis, M. A., Picker, L. J. & Früh, K., Apr 2 2010, In : Science. 328, 5974, p. 102-106 5 p.

Research output: Contribution to journalArticle

172 Scopus citations

Immune response to the West Nile virus in aged non- human primates

Wertheimer, A. M., Uhrlaub, J. L., Hirsch, A., Medigeshi, G., Sprague, J., Legasse, A., Wilk, J., Wiley, C. A., Didier, P., Tesh, R. B., Murray, K. O., Axthelm, M. K., Wong, S. W. & Nikolich-Žugich, J., Dec 15 2010, In : PloS one. 5, 12, e15514.

Research output: Contribution to journalArticle

16 Scopus citations

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses

Leone, A., Rohankhedkar, M., Okoye, A., Legasse, A., Axthelm, M. K., Villinger, F., Piatak, M., Lifson, J. D., Assouline, B., Morre, M., Picker, L. J. & Sodora, D. L., Aug 1 2010, In : Journal of Immunology. 185, 3, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates

Čičin-Šain, L., Smyk-Paerson, S., Currier, N., Byrd, L., Koudelka, C., Robinson, T., Swarbrick, G., Tackitt, S., Legasse, A., Fischer, M., Nikolich-Žugich, D., Park, B., Hobbs, T., Doane, C. J., Mori, M., Axthelm, M. T., Lewinsohn, D. A. & Nikolich-Žugich, J., Jun 15 2010, In : Journal of Immunology. 184, 12, p. 6739-6745 7 p.

Research output: Contribution to journalArticle

82 Scopus citations
2009

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M. K., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J. A., Jarvis, M. A. & Picker, L. J., Mar 1 2009, In : Nature medicine. 15, 3, p. 293-299 7 p.

Research output: Contribution to journalArticle

509 Scopus citations

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

Okoye, A., Park, H., Rohankhedkar, M., Coyne-Johnson, L., Lum, R., Walker, J. M., Planer, S. L., Legasse, A. W., Sylwester, A. W., Piatak, M., Lifson, J. D., Sodora, D. L., Villinger, F., Axthelm, M. K., Schmitz, J. E. & Picker, L. J., Jul 6 2009, In : Journal of Experimental Medicine. 206, 7, p. 1575-1588 14 p.

Research output: Contribution to journalArticle

56 Scopus citations

Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques

Novy, M. J., Duffy, L., Axthelm, M. K., Sadowsky, D. W., Witkin, S. S., Gravett, M. G., Cassell, G. H. & Waites, K. B., Jan 1 2009, In : Reproductive Sciences. 16, 1, p. 56-70 15 p.

Research output: Contribution to journalArticle

113 Scopus citations

Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD)

Orzechowska, B. U., Manoharan, M., Sprague, J., Estep, R. D., Axthelm, M. K. & Wong, S. W., Oct 1 2009, In : Journal of medical primatology. 38, SUPPL. 1, p. 2-7 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2008

Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques

Price, D. A., Bitmansour, A. D., Edgar, J. B., Walker, J. M., Axthelm, M. K., Douek, D. C. & Picker, L. J., Jan 1 2008, In : Journal of Immunology. 180, 1, p. 269-280 12 p.

Research output: Contribution to journalArticle

28 Scopus citations