Michael Axthelm

Associate Scientist

  • 7298 Citations
  • 41 h-Index
1978 …2020

Research output per year

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Research Output

  • 7298 Citations
  • 41 h-Index
  • 125 Article
  • 8 Comment/debate
  • 1 Review article
2010

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates

Čičin-Šain, L., Smyk-Paerson, S., Currier, N., Byrd, L., Koudelka, C., Robinson, T., Swarbrick, G., Tackitt, S., Legasse, A., Fischer, M., Nikolich-Žugich, D., Park, B., Hobbs, T., Doane, C. J., Mori, M., Axthelm, M. T., Lewinsohn, D. A. & Nikolich-Žugich, J., Jun 15 2010, In : Journal of Immunology. 184, 12, p. 6739-6745 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates (J. Immunol. (2010) 184 (6739-6745))

Čicin-Šain, L., Smyk-Paerson, S., Currier, N., Byrd, L., Koudelka, C., Robinson, T., Swarbrick, G., Tackitt, S., Legasse, A., Fischer, M., Nikolich-Žugich, D., Park, B., Hobbs, T., Doane, C. J., Mori, M., Axthelm, M. T., Lewinsohn, D. A. & Nikolich-Žugich., J., Oct 1 2010, In : Journal of Immunology. 185, 7, 1 p.

Research output: Contribution to journalComment/debate

2009

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M. K., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J. A., Jarvis, M. A. & Picker, L. J., Mar 1 2009, In : Nature medicine. 15, 3, p. 293-299 7 p.

Research output: Contribution to journalArticle

514 Scopus citations

Erratum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge (Nature Medicine (2009) 15 (293-299))

Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M. K., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J. A., Jarvis, M. A. & Picker, L. J., Apr 1 2009, In : Nature medicine. 15, 4, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

Okoye, A., Park, H., Rohankhedkar, M., Coyne-Johnson, L., Lum, R., Walker, J. M., Planer, S. L., Legasse, A. W., Sylwester, A. W., Piatak, M., Lifson, J. D., Sodora, D. L., Villinger, F., Axthelm, M. K., Schmitz, J. E. & Picker, L. J., Jul 6 2009, In : Journal of Experimental Medicine. 206, 7, p. 1575-1588 14 p.

Research output: Contribution to journalArticle

56 Scopus citations

Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques

Novy, M. J., Duffy, L., Axthelm, M. K., Sadowsky, D. W., Witkin, S. S., Gravett, M. G., Cassell, G. H. & Waites, K. B., Jan 1 2009, In : Reproductive Sciences. 16, 1, p. 56-70 15 p.

Research output: Contribution to journalArticle

115 Scopus citations

Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD)

Orzechowska, B. U., Manoharan, M., Sprague, J., Estep, R. D., Axthelm, M. K. & Wong, S. W., Oct 1 2009, In : Journal of medical primatology. 38, SUPPL. 1, p. 2-7 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2008

Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques

Price, D. A., Bitmansour, A. D., Edgar, J. B., Walker, J. M., Axthelm, M. K., Douek, D. C. & Picker, L. J., Jan 1 2008, In : Journal of Immunology. 180, 1, p. 269-280 12 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Productive simian virus 40 infection of neurons in immunosuppressed rhesus monkeys

Dang, X., Wüthrich, C., Axthelm, M. K. & Koralnik, I. J., Aug 1 2008, In : Journal of Neuropathology and Experimental Neurology. 67, 8, p. 784-792 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Replication in a superficial epithelial cell niche explains the lack of pathogenicity of primate foamy virus infections

Murray, S. M., Picker, L. J., Axthelm, M. K., Hudkins, K., Alpers, C. E. & Linial, M. L., Jun 2008, In : Journal of virology. 82, 12, p. 5981-5985 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Rhesus macaque rhadinovirus-associated non-Hodgkin lymphoma: animal model for KSHV-associated malignancies

Orzechowska, B. U., Powers, M. F., Sprague, J., Li, H., Yen, B., Searles, R. P., Axthelm, M. K. & Wong, S. W., Nov 15 2008, In : Blood. 112, 10, p. 4227-4234 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
2007

Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates

Čičin-Šain, L., Messaoudi, I., Park, B., Currier, N., Planer, S., Fischer, M., Tackitt, S., Nikolich-Žugich, D., Legasse, A., Axthelm, M. K., Picker, L. J., Mori, M. & Nikolich-Žugich, J., Dec 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 50, p. 19960-19965 6 p.

Research output: Contribution to journalArticle

96 Scopus citations

Erratum: Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection (Journal of Experimental Medicine (September 3, 2007) 204, 9, (2171-2185))

Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A. W., Piatak, M., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M. K., Grossman, Z. & Picker, L. J., Oct 1 2007, In : Journal of Experimental Medicine. 204, 10, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model

Gravett, M. G., Adams, K. M., Sadowsky, D. W., Grosvenor, A. R., Witkin, S. S., Axthelm, M. K. & Novy, M. J., Nov 2007, In : American journal of obstetrics and gynecology. 197, 5, p. 518.e1-518.e8

Research output: Contribution to journalArticle

68 Scopus citations

Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection

Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A. W., Piatak, M., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M. K., Grossman, Z. & Picker, L. J., Sep 3 2007, In : Journal of Experimental Medicine. 204, 9, p. 2171-2185 15 p.

Research output: Contribution to journalArticle

203 Scopus citations
2006

Anti-OX40 (CD134) administration to nonhuman primates: Immunostimulatory effects and toxicokinetic study

Weinberg, A. D., Thalhofer, C., Morris, N., Walker, J. M., Seiss, D., Wong, S., Axthelm, M. K., Picker, L. J. & Urba, W. J., Nov 1 2006, In : Journal of Immunotherapy. 29, 6, p. 575-585 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Expanded tissue targets for foamy virus replication with simian immunodeficiency virus-induced immunosuppression

Murray, S. M., Picker, L. J., Axthelm, M. K. & Linial, M. L., Jan 2006, In : Journal of virology. 80, 2, p. 663-670 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Germinal center function in the spleen during simian HIV infection in rhesus monkeys

Margolin, D. H., Saunders, E. H., Bronfin, B., De Rosa, N., Axthelm, M. K., Goloubeva, O. G., Eapen, S., Gelman, R. S. & Letvin, N. L., Jul 15 2006, In : Journal of Immunology. 177, 2, p. 1108-1119 12 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

IL-15 induces CD4+ effector memory T cell production and tissue emigration in nonhuman primates

Picker, L. J., Reed-Inderbitzin, E. F., Hagen, S. I., Edgar, J. B., Hansen, S. G., Legasse, A., Planer, S., Piatak, M., Lifson, J. D., Maino, V. C., Axthelm, M. K. & Villinger, F., Jun 1 2006, In : Journal of Clinical Investigation. 116, 6, p. 1514-1524 11 p.

Research output: Contribution to journalArticle

143 Scopus citations
2005

Rearrangement of simian virus 40 regulatory region is not required for induction of progressive multifocal leukoencephalopathy in immunosuppressed rhesus monkeys

Dang, X., Axthelm, M. K., Letvin, N. L. & Koralnik, I. J., Feb 1 2005, In : Journal of virology. 79, 3, p. 1361-1366 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2004

Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection

Picker, L. J., Hagen, S. I., Lum, R., Reed-Inderbitzin, E. F., Daly, L. M., Sylwester, A. W., Walker, J. M., Siess, D. C., Piatak, M., Wang, C., Allison, D. B., Maino, V. C., Lifson, J. D., Kodama, T. & Axthelm, M. K., Nov 15 2004, In : Journal of Experimental Medicine. 200, 10, p. 1299-1314 16 p.

Research output: Contribution to journalArticle

254 Scopus citations

Meningoencephalitis and demyelination are pathologic manifestations of primary polyomavirus infection in immunosuppressed rhesus monkeys

Axthelm, M. K., Koralnik, I. J., Dang, X., Wüthrich, C., Rohne, D., Stillman, I. E. & Letvin, N. L., Jul 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 7, p. 750-758 9 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Neutralization sensitivity of a simian-human immunodeficiency virus (SHIV-HXBc2P 3.2N) isolated from an infected rhesus macaque with neurological disease

Song, B., Cayabyab, M., Phan, N., Wang, L., Axthelm, M. K., Letvin, N. L. & Sodroski, J. G., Apr 25 2004, In : Virology. 322, 1, p. 168-181 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prevention of Coronary Hyperreactivity in Preatherogenic Menopausal Rhesus Monkeys by Transdermal Progesterone

Hermsmeyer, R. K., Mishra, R. G., Pavcnik, D., Uchida, B., Axthelm, M. K., Stanczyk, F. Z., Burry, K. A., Illingworth, D. R., Kaski, J. C. & Nordt, F. J., May 1 2004, In : Arteriosclerosis, thrombosis, and vascular biology. 24, 5, p. 955-961 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Rapid CD4+ T-Lymphocyte Depletion in Rhesus Monkeys Infected with a Simian-Human Immunodeficiency Virus Expressing the Envelope Glycoproteins of a Primary Dual-Tropic Ethiopian Clade C HIV Type 1 Isolate

Cayabyab, M., Rohne, D., Pollakis, G., Mische, C., Messele, T., Abebe, A., Etemad-Moghadam, B., Yang, P., Henson, S., Axthelm, M., Goudsmit, J., Letvin, N. L. & Sodroski, J., Jan 1 2004, In : AIDS Research and Human Retroviruses. 20, 1, p. 27-40 14 p.

Research output: Contribution to journalArticle

18 Scopus citations
2003
25 Scopus citations

Role of CD8+ lymphocytes in control and clearance of measles virus infection of rhesus monkeys

Permar, S. R., Klumpp, S. A., Mansfield, K. G., Kim, W. K., Gorgone, D. A., Lifton, M. A., Williams, K. C., Schmitz, J. E., Reimann, K. A., Axthelm, M. K., Polack, F. P., Griffin, D. E. & Letvin, N. L., Apr 1 2003, In : Journal of virology. 77, 7, p. 4396-4400 5 p.

Research output: Contribution to journalArticle

85 Scopus citations
2002

Development and homeostasis of T cell memory in rhesus macaque

Pitcher, C. J., Hagen, S. I., Walker, J. M., Lum, R., Mitchell, B. L., Maino, V. C., Axthelm, M. K. & Picker, L. J., Jan 1 2002, In : Journal of Immunology. 168, 1, p. 29-43 15 p.

Research output: Contribution to journalArticle

Open Access
391 Scopus citations

High frequency of virus-specific B lymphocytes in germinal centers of simian-human immunodeficiency virus-infected rhesus monkeys

Margolin, D. H., Helmuth Saunders, E. F., Bronfin, B., De Rosa, N., Axthelm, M. K., Alvarez, X. & Letvin, N. L., 2002, In : Journal of virology. 76, 8, p. 3965-3973 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Understanding the basis of CD4+ T-cell depletion in macaques infected by a simian-human immunodeficiency virus

Etemad-Moghadam, B., Rhone, D., Steenbeke, T., Sun, Y., Manola, J., Gelman, R., Fanton, J. W., Racz, P., Tenner-Racz, K., Axthelm, M. K., Letvin, N. L. & Sodroski, J., May 6 2002, In : Vaccine. 20, 15, p. 1934-1937 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
2001

Maternal or fetal origin of rhesus monkey (Macaca mulatta) amniotic fluid leukocytes can be identified by polymerase chain reaction using the zinc finger Y gene

Macias, A. E., Wong, S. W., Sadowsky, D. W., Luetjens, C. M., Axthelm, M. K., Gravett, M. G., Haluska, G. J. & Novy, M. J., Dec 3 2001, In : American Journal of Primatology. 55, 3, p. 159-170 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Membrane-fusing capacity of the human immunodeficiency virus envelope proteins determines the efficiency of CD4+ T-cell depletion in macaques infected by a simian-human immunodeficiency virus

Etemad-Moghadam, B., Rhone, D., Steenbeke, T., Sun, Y., Manola, J., Gelman, R., Fanton, J. W., Racz, P., Tenner-Racz, K., Axthelm, M. K., Letvin, N. L. & Sodroski, J., Jun 9 2001, In : Journal of virology. 75, 12, p. 5646-5655 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

Stimulation of antiviral antibody response in SHIV-IIIB-infected macaques

Muller, S., Margolin, D. H., Min, G., Lou, D., Nara, P., Axthelm, M. K. & Kohler, H., Jan 1 2001, In : Scandinavian Journal of Immunology. 54, 4, p. 383-395 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Vaccine-elicited V3 loop-specific antibodies in rhesus monkeys and control of a simian-human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate envelope

Letvin, N. L., Robinson, S., Rohne, D., Axthelm, M. K., Fanton, J. W., Bilska, M., Palker, T. J., Liao, H. X., Haynes, B. F. & Montefiori, D. C., May 17 2001, In : Journal of virology. 75, 9, p. 4165-4175 11 p.

Research output: Contribution to journalArticle

54 Scopus citations
2000

Patterns of genomic sequence diversity among their simian immunodeficiency viruses suggest that L'Hoest monkeys (Cercopithecus lhoesti) are a natural lentivirus reservoir

Beer, B. E., Bailes, E., Dapolito, G., Campbell, B. J., Goeken, R. M., Axthelm, M. K., Markham, P. D., Bernard, J., Zagury, D., Franchini, G., Sharp, P. M. & Hirsch, V. M., Apr 12 2000, In : Journal of virology. 74, 8, p. 3892-3898 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Simian retrovirus serogroup 5: Partial gag-prt sequence and viral RNA distribution in an infected rhesus macaque

Li, B., Axthelm, M. K. & Machida, C. A., Dec 18 2000, In : Virus Genes. 21, 3, p. 241-248 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
1999

Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2)

Cayabyab, M., Karlsson, G. B., Etemad-Moghadam, B. A., Hofmann, W., Steenbeke, T., Halloran, M., Fanton, J. W., Axthelm, M. K., Letvin, N. L. & Sodroski, J. G., Jan 23 1999, In : Journal of virology. 73, 2, p. 976-984 9 p.

Research output: Contribution to journalArticle

79 Scopus citations

Characterization of a novel simian immunodeficiency virus (SIV) from L'Hoest monkeys (Cercopithecus l'hoesti): Implications for the origins of SIVmnd and other primate lentiviruses

Hirsch, V. M., Campbell, B. J., Bailes, E., Goeken, R., Brown, C., Elkins, W. R., Axthelm, M., Murphey-Corb, M. & Sharp, P. M., Jan 23 1999, In : Journal of virology. 73, 2, p. 1036-1045 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

Induction of B cell hyperplasia in simian immunodeficiency virus- infected rhesus macaques with the simian homologue of Kaposi's sarcoma- associated herpesvirus

Wong, S. W., Bergquam, E. P., Swanson, R. M., Lee, F. W., Shiigi, S. M., Avery, N. A., Fanton, J. W. & Axthelm, M. K., Sep 20 1999, In : Journal of Experimental Medicine. 190, 6, p. 827-840 14 p.

Research output: Contribution to journalArticle

111 Scopus citations

Molecular cloning and cell-specific growth characterization of polymorphic variants of type D serogroup 2 Simian retroviruses

Marracci, G. H., Avery, N. A., Shiigi, S. M., Couch, G., Palmer, H., Pilcher, K. Y., Nichols, H., Hallick, L. M., Axthelm, M. K. & Machida, C. A., Aug 15 1999, In : Virology. 261, 1, p. 43-58 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo

Bergquam, E. P., Avery, N., Shiigi, S. M., Axthelm, M. K. & Wong, S. W., Aug 23 1999, In : Journal of virology. 73, 9, p. 7874-7876 3 p.

Research output: Contribution to journalArticle

38 Scopus citations

Self-injurious behavior is decreased by cyproterone acetate in adult male rhesus (Macaca mulatta)

Eaton, G. G., Worlein, J. M., Kelley, S. T., Vijayaraghavan, S., Hess, D. L., Axthelm, M. K. & Bethea, C. L., Apr 1999, In : Hormones and Behavior. 35, 2, p. 195-203 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
Open Access
225 Scopus citations

Viral burden and disease progression in rhesus monkeys infected with chimeric simian-human immunodeficiency viruses

Reimann, K. A., Watson, A., Dailey, P. J., Lin, W., Lord, C. I., Steenbeke, T. D., Parker, R. A., Axthelm, M. K. & Karlsson, G. B., Mar 30 1999, In : Virology. 256, 1, p. 15-21 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Experimental Old Dog Encephalitis (ODE) in a Gnotobiotic Dog

Axthelm, M. K. & Krakowka, S., Nov 1998, In : Veterinary pathology. 35, 6, p. 527-534 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ovarian steroid protection against coronary artery hyperreactivity in rhesus monkeys

Minshall, R. D., Stanczyk, F. Z., Miyagawa, K., Uchida, B., Axthelm, M., Novy, M. & Hermsmeyer, K., Nov 11 1998, In : Journal of Clinical Endocrinology and Metabolism. 83, 2, p. 649-659 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques

Karlsson, G. B., Halloran, M., Schenten, D., Lee, J., Racz, P., Tenner-Racz, K., Manola, J., Gelman, R., Etemad-Moghadam, B., Desjardins, E., Wyatt, R., Gerard, N. P., Marcon, L., Margolin, D., Fanton, J., Axthelm, M. K., Letvin, N. L. & Sodroski, J., Sep 21 1998, In : Journal of Experimental Medicine. 188, 6, p. 1159-1171 13 p.

Research output: Contribution to journalArticle

93 Scopus citations
1997

Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys

Karlsson, G. B., Halloran, M., Li, J., Park, I. W., Gomila, R., Reimann, K. A., Axthelm, M. K., Iliff, S. A., Letvin, N. L. & Sodroski, J., Jun 1 1997, In : Journal of virology. 71, 6, p. 4218-4225 8 p.

Research output: Contribution to journalArticle

176 Scopus citations

Reactivity-based coronary vasospasm independent of atherosclerosis in rhesus monkeys

Hermsmeyer, K., Miyagawa, K., Kelley, S. T., Rösch, J., Hall, A. S., Axthelm, M. K. & Greenberg, B., Mar 1 1997, In : Journal of the American College of Cardiology. 29, 3, p. 671-680 10 p.

Research output: Contribution to journalArticle

22 Scopus citations