Michael Axthelm

Associate Scientist

  • 7298 Citations
  • 41 h-Index
1978 …2020

Research output per year

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Research Output

  • 7298 Citations
  • 41 h-Index
  • 125 Article
  • 8 Comment/debate
  • 1 Review article
1981

Congenital internal hydrocephalus in Polled Hereford cattle.

Axthelm, M. K., Leipold, H. W. & Phillips, R. M., Apr 1 1981, In : Veterinary medicine, small animal clinician : VM, SAC. 76, 4, p. 567-570 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
1982

Canine parvovirus infection potentiates canine distemper encephalitis attributable to modified live-virus vaccine

Krakowka, S., Olsen, R. G., Axthelm, M. K., Rice, J. & Winters, K., Nov 3 1982, In : Journal of the American Veterinary Medical Association. 180, 2, p. 137-139 3 p.

Research output: Contribution to journalArticle

35 Scopus citations

Effects of cerebrospinal fluid sample collection on frequency and onset of acute fatal canine distemper-associated encephalomyelitis.

Krakowka, S., Axthelm, M. & Austin, N. J., Sep 1 1982, In : American journal of veterinary research. 43, 9, p. 1678-1680 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
1984

In vitro propagation of canine distemper virus: Establishment of persistent infection in Vero cells

Metzler, A. E., Krakowka, S., Axthelm, M. K. & Gorham, J. R., Dec 1 1984, In : American journal of veterinary research. 45, 10, p. 2211-2215 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
1986
20 Scopus citations

In vitro detection of canine distemper virus nucleic acid with a virus-specific cDNA probe by dot-blot and in situ hybridization

Oglesbee, M., Jackwood, D., Perrine, K., Axthelm, M., Krakowka, S. & Rice, J., Nov 1986, In : Journal of Virological Methods. 14, 3-4, p. 195-211 17 p.

Research output: Contribution to journalArticle

14 Scopus citations

Repeated suppression of lymphocyte blastogenesis following vaccinations of CPV-immune dogs with modified-live CPV vaccines

Mastro, J. M., Axthelm, M., Mathes, L. E., Krakowka, S., Ladiges, W. & Olsen, R. G., Sep 1986, In : Veterinary Microbiology. 12, 3, p. 201-211 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
1987

Albumin leakage into cerebrospinal fluid of dogs lethally infected with R252 canine distemper virus

Johnson, G. C., Krakowka, S. & Axthelm, M. K., Feb 1987, In : Journal of Neuroimmunology. 14, 1, p. 61-74 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Canine distemper virus: the early blood-brain barrier lesion

Axthelm, M. K. & Krakowka, S., Jan 1 1987, In : Acta Neuropathologica. 75, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Canine distemper virus: in vivo virulence of in vitro-passaged persistent virus strains.

Axthelm, M. K., Krakowka, S. & Gorham, J. R., Feb 1 1987, In : American journal of veterinary research. 48, 2, p. 227-234 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Canine distemper virus-induced thrombocytopenia.

Axthelm, M. K. & Krakowka, S., Aug 1 1987, In : American journal of veterinary research. 48, 8, p. 1269-1275 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Effects of induced thrombocytopenia on viral invasion of the central nervous system in canine distemper virus infection

Krakowka, S., Axthelm, M. K. & Gorham, J. R., Jul 1987, In : Journal of Comparative Pathology. 97, 4, p. 441-450 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Establishment of central nervous system infection by canine distemper virus: Breach of the blood-brain barrier and facilitation by antiviral antibody

Krakowka, S., Cork, L. C., Winkelstein, J. A. & Axthelm, M. K., Dec 1987, In : Veterinary Immunology and Immunopathology. 17, 1-4, p. 471-482 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Immunosuppression by canine distemper virus: Modulation of in vitro immunoglobulin synthesis, interleukin release and prostaglandin E2 production

Krakowka, S., Ringler, S. S., Lewis, M., Olsen, R. G. & Axthelm, M. K., Jun 1987, In : Veterinary Immunology and Immunopathology. 15, 3, p. 181-201 21 p.

Research output: Contribution to journalArticle

30 Scopus citations

Prolonged Viral Antigen Retention in the Brain of a Gnotobiotic Dog Experimentally Infected with Canine Distemper Virus

Johnson, G. C., Krakowka, S. & Axthelm, M. K., Jan 1987, In : Veterinary pathology. 24, 1, p. 87-89 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
1989

Characterization of a synthetic envelope peptide of SRV-1 and SRV-2 virus that specifically binds rhesus anti-SRV-1 and anti-SRV-2 neutralizing antibodies.

Malley, A., Shiigi, S., Benjamini, E., Werner, L., Leung, C. Y., Kwang, H. S., Axthelm, M. & Hallick, L. M., 1989, In : Advances in experimental medicine and biology. 251, p. 169-173 5 p.

Research output: Contribution to journalArticle

Serologic and virologic analysis of type D simian retrovirus infection in a colony of Celebes black Macaques (Macaca nigra)

Shiigi, S., Wilson, B., Leo, G., MacDonald, N., Toyooka, D., Hallick, L., Karty, R., Belozer, M. L., McNulty, W., Wolff, J., Van Bueren, A., Howard, C. & Axthelm, M., Jan 1 1989, In : Journal of medical primatology. 18, 3-4, p. 185-193 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
1990

Nonhuman primate models for acquired immunodeficiency syndrome

Axthelm, M. K. & Shiigi, S. M., Oct 2 1990, In : Journal of medical primatology. 19, 3-4, p. 163-165 3 p.

Research output: Contribution to journalArticle

3 Scopus citations
1991

Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein.

Malley, A., Werner, L., Benjamini, E., Leung, C. Y., Torres, J., Pangares, N., Shiigi, S. & Axthelm, M., Jun 1991, In : Journal of medical primatology. 20, 4, p. 177-181 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
1992

Characterization of T cell epitopes on the envelope glycoprotein of simian retrovirus 1 and 2 (SRV-1 and SRV-2) in several mouse strains

Malley, A., Torres, J. V., Benjamini, E., Pangares, N. & Axthelm, M., Jan 1 1992, In : Molecular Immunology. 29, 7-8, p. 999-1004 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Diagnostic exercise: Sudden death in a rhesus macaque (Macaca mulatta)

Iliff-Sizemore, S. A., Axthelm, M. K. & Edwards, J. L., Jan 1 1992, In : Laboratory Animal Science. 42, 2, p. 202-203 2 p.

Research output: Contribution to journalArticle

Summary report: Workshop on animal models of human immunodeficiency virus infections in humans

April, M., Axthelm, M. K., Baskin, G., Clark, E. A., Desrosiers, R., Gartner, S., Jahrling, P. B., Marx, P., McClure, H. M., Morton, W. R., Popovic, M., Ringler, D., Schultz, K., Wetherall, N., Whitehair, L. & Whitney, R. A., Jan 1 1992, In : Military medicine. 157, 12, p. 662-663 2 p.

Research output: Contribution to journalArticle

1993

An Epitope on the Surface Envelope Glycoprotein (gp130) of Simian Immunodeficiency Virus (SIVmac) Involved in Viral Neutralization and T Cell Activation

Torres, J. V., Malley, A., Banapour, B., Anderson, D. E., Axthelm, M. K., Gardner, M. B. & Benjamini, E., May 1993, In : AIDS Research and Human Retroviruses. 9, 5, p. 423-430 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques.

Torres, J. V., Anderson, D. E., Malley, A., Banapour, B., Axthelm, M. K., Benjamini, E. & Gardner, M. B., Jan 1 1993, In : Journal of medical primatology. 22, 2-3, p. 129-137 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Type D SRV-2 virus-specific CD8+ and CD4- CD8- T cells that regulate virus-induced T cell proliferation in Celebes macaques.

Malley, A., Pangares, N., Mayo, S. K., Zeleny-Pooley, M., Torres, J. V., Benjamin, E. & Axthelm, M. K., Jan 1 1993, In : Journal of medical primatology. 22, 2-3, p. 80-85 6 p.

Research output: Contribution to journalArticle

1994

Polymerase chain reaction detection of type D simian retrovirus proviral DNA from infected macaques

Pilcher, K. Y., Avery, N., Shiigi, S. M., Pangares, N., Malley, A., Axthelm, M. K. & Machida, C. A., Dec 1994, In : Journal of Virological Methods. 50, 1-3, p. 75-86 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Psychological well‐being in paired adult female rhesus (Macaca mulatta)

Eaton, G. G., Kelley, S. T., Axthelm, M. K., Iliff‐Sizemore, S. A. & Shiigi, S. M., 1994, In : American Journal of Primatology. 33, 2, p. 89-99 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Synthesis and transsulfuration of homocysteine in blood.

Malinow, M. R., Axthelm, M. K., Meredith, M. J., MacDonald, N. A. & Upson, B. M., Mar 1 1994, In : Journal of Laboratory and Clinical Medicine. 123, 3, p. 421-429 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
1995

Assessing genetic‐based therapies for AIDS using the simian immunodeficiency virus

Endres, C. L., Bergquam, E., Axthelm, M. K. & Wong, S. W., May 1995, In : Journal of medical primatology. 24, 3, p. 141-144 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Histologic and immunocytochemical characterization of canine distemper-associated metaphyseal bone lesions in young dogs following experimental infection.

Baumgärtner, W., Boyce, R. W., Weisbrode, S. E., Aldinger, S., Axthelm, M. K. & Krakowka, S., Nov 1995, In : Veterinary pathology. 32, 6, p. 702-709 8 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Metaphyseal bone lesions in young dogs with systemic canine distemper virus infection

Baumgärtner, W., Boyce, R. W., Alldinger, S., Axthelm, M. K., Weisbrode, S. E., Krakowka, S. & Gaedke, K., May 1995, In : Veterinary Microbiology. 44, 2-4, p. 201-209 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Simian AIDS type D serogroup 2 retrovirus: Isolation of an infectious molecular clone and sequence analyses of its envelope glycoprotein gene and 3' long terminal repeat

Marracci, G. H., Kelley, R. D., Pilcher, K. Y., Crabtree, L., Shiigi, S. M., Avery, N., Leo, G., Webb, M. C., Hallick, L. M., Axthelm, M. K. & Machida, C. A., Jan 1 1995, In : Journal of virology. 69, 4, p. 2621-2628 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Suppression of simian immunodeficiency virus replication by human immunodeficiency virus type 1 trans-dominant negative rev mutants

Endres, C. L., Bergquam, E. P., Axthelm, M. K. & Wong, S. W., Jan 1 1995, In : Journal of virology. 69, 8, p. 5164-5166 3 p.

Research output: Contribution to journalComment/debate

7 Scopus citations
1996

Germ cell defects and hematopoietic hypersensitivity to γ-interferon in mice with a targeted disruption of the fanconi anemia C gene

Whitney, M. A., Royle, G., Low, M. J., Kelly, M. A., Axthelm, M. K., Reifsteck, C., Olson, S., Braun, R. E., Heinrich, M. C., Rathbun, R. K., Bagby, G. C. & Grompe, M., Jul 1 1996, In : Blood. 88, 1, p. 49-58 10 p.

Research output: Contribution to journalArticle

222 Scopus citations
1997

Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys

Karlsson, G. B., Halloran, M., Li, J., Park, I. W., Gomila, R., Reimann, K. A., Axthelm, M. K., Iliff, S. A., Letvin, N. L. & Sodroski, J., Jun 1 1997, In : Journal of virology. 71, 6, p. 4218-4225 8 p.

Research output: Contribution to journalArticle

176 Scopus citations

Reactivity-based coronary vasospasm independent of atherosclerosis in rhesus monkeys

Hermsmeyer, K., Miyagawa, K., Kelley, S. T., Rösch, J., Hall, A. S., Axthelm, M. K. & Greenberg, B., Mar 1 1997, In : Journal of the American College of Cardiology. 29, 3, p. 671-680 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Experimental Old Dog Encephalitis (ODE) in a Gnotobiotic Dog

Axthelm, M. K. & Krakowka, S., Nov 1998, In : Veterinary pathology. 35, 6, p. 527-534 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ovarian steroid protection against coronary artery hyperreactivity in rhesus monkeys

Minshall, R. D., Stanczyk, F. Z., Miyagawa, K., Uchida, B., Axthelm, M., Novy, M. & Hermsmeyer, K., Nov 11 1998, In : Journal of Clinical Endocrinology and Metabolism. 83, 2, p. 649-659 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques

Karlsson, G. B., Halloran, M., Schenten, D., Lee, J., Racz, P., Tenner-Racz, K., Manola, J., Gelman, R., Etemad-Moghadam, B., Desjardins, E., Wyatt, R., Gerard, N. P., Marcon, L., Margolin, D., Fanton, J., Axthelm, M. K., Letvin, N. L. & Sodroski, J., Sep 21 1998, In : Journal of Experimental Medicine. 188, 6, p. 1159-1171 13 p.

Research output: Contribution to journalArticle

93 Scopus citations
1999

Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2)

Cayabyab, M., Karlsson, G. B., Etemad-Moghadam, B. A., Hofmann, W., Steenbeke, T., Halloran, M., Fanton, J. W., Axthelm, M. K., Letvin, N. L. & Sodroski, J. G., Jan 23 1999, In : Journal of virology. 73, 2, p. 976-984 9 p.

Research output: Contribution to journalArticle

79 Scopus citations

Characterization of a novel simian immunodeficiency virus (SIV) from L'Hoest monkeys (Cercopithecus l'hoesti): Implications for the origins of SIVmnd and other primate lentiviruses

Hirsch, V. M., Campbell, B. J., Bailes, E., Goeken, R., Brown, C., Elkins, W. R., Axthelm, M., Murphey-Corb, M. & Sharp, P. M., Jan 23 1999, In : Journal of virology. 73, 2, p. 1036-1045 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

Induction of B cell hyperplasia in simian immunodeficiency virus- infected rhesus macaques with the simian homologue of Kaposi's sarcoma- associated herpesvirus

Wong, S. W., Bergquam, E. P., Swanson, R. M., Lee, F. W., Shiigi, S. M., Avery, N. A., Fanton, J. W. & Axthelm, M. K., Sep 20 1999, In : Journal of Experimental Medicine. 190, 6, p. 827-840 14 p.

Research output: Contribution to journalArticle

111 Scopus citations

Molecular cloning and cell-specific growth characterization of polymorphic variants of type D serogroup 2 Simian retroviruses

Marracci, G. H., Avery, N. A., Shiigi, S. M., Couch, G., Palmer, H., Pilcher, K. Y., Nichols, H., Hallick, L. M., Axthelm, M. K. & Machida, C. A., Aug 15 1999, In : Virology. 261, 1, p. 43-58 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo

Bergquam, E. P., Avery, N., Shiigi, S. M., Axthelm, M. K. & Wong, S. W., Aug 23 1999, In : Journal of virology. 73, 9, p. 7874-7876 3 p.

Research output: Contribution to journalArticle

38 Scopus citations

Self-injurious behavior is decreased by cyproterone acetate in adult male rhesus (Macaca mulatta)

Eaton, G. G., Worlein, J. M., Kelley, S. T., Vijayaraghavan, S., Hess, D. L., Axthelm, M. K. & Bethea, C. L., Apr 1999, In : Hormones and Behavior. 35, 2, p. 195-203 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
Open Access
225 Scopus citations

Viral burden and disease progression in rhesus monkeys infected with chimeric simian-human immunodeficiency viruses

Reimann, K. A., Watson, A., Dailey, P. J., Lin, W., Lord, C. I., Steenbeke, T. D., Parker, R. A., Axthelm, M. K. & Karlsson, G. B., Mar 30 1999, In : Virology. 256, 1, p. 15-21 7 p.

Research output: Contribution to journalArticle

48 Scopus citations
2000

Patterns of genomic sequence diversity among their simian immunodeficiency viruses suggest that L'Hoest monkeys (Cercopithecus lhoesti) are a natural lentivirus reservoir

Beer, B. E., Bailes, E., Dapolito, G., Campbell, B. J., Goeken, R. M., Axthelm, M. K., Markham, P. D., Bernard, J., Zagury, D., Franchini, G., Sharp, P. M. & Hirsch, V. M., Apr 12 2000, In : Journal of virology. 74, 8, p. 3892-3898 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Simian retrovirus serogroup 5: Partial gag-prt sequence and viral RNA distribution in an infected rhesus macaque

Li, B., Axthelm, M. K. & Machida, C. A., Dec 18 2000, In : Virus Genes. 21, 3, p. 241-248 8 p.

Research output: Contribution to journalArticle

17 Scopus citations