• 29158 Citations
  • 83 h-Index
1976 …2021
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Research Output 1979 2019

  • 29158 Citations
  • 83 h-Index
  • 198 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Chapter
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Article
2011
638 Citations (Scopus)

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

Hansen, S., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., Whizin, N., Oswald, K., Shoemaker, R., Swanson, T., Legasse, A. W., Chiuchiolo, M. J., Parks, C. L., Axthelm, M., Nelson, J., Jarvis, M. A., Piatak, M., Lifson, J. D. & Picker, L., May 26 2011, In : Nature. 473, 7348, p. 523-527 5 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Vaccines
T-Lymphocytes
Cytomegalovirus
Macaca mulatta
2010
168 Citations (Scopus)

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

Hansen, S., Powers, C. J., Richards, R., Ventura, A. B., Ford, J. C., Siess, D., Axthelm, M., Nelson, J., Jarvis, M. A., Picker, L. & Frueh, K., Apr 2 2010, In : Science. 328, 5974, p. 102-106 5 p.

Research output: Contribution to journalArticle

Superinfection
Cytomegalovirus
T-Lymphocytes
Macaca mulatta
Major Histocompatibility Complex
36 Citations (Scopus)

Evidence of early B-cell dysregulation in simian immunodeficiency virus infection: Rapid depletion of naïve and memory B-cell subsets with delayed reconstitution of the naïve B-cell population

Kuhrt, D., Faith, S. A., Leone, A., Rohankedkar, M., Sodora, D. L., Picker, L. & Cole, K. S., Mar 2010, In : Journal of Virology. 84, 5, p. 2466-2476 11 p.

Research output: Contribution to journalArticle

B-Lymphocyte Subsets
Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virus Diseases
B-lymphocytes
27 Citations (Scopus)

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses

Leone, A., Rohankhedkar, M., Okoye, A., Legasse, A., Axthelm, M., Villinger, F., Piatak, M., Lifson, J. D., Assouline, B., Morre, M., Picker, L. & Sodora, D. L., Aug 1 2010, In : Journal of Immunology. 185, 3, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

Interleukin-7
Simian Immunodeficiency Virus
Macaca
T-Lymphocytes
Therapeutics
20 Citations (Scopus)

In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques

Tjernlund, A., Zhu, J., Laing, K., Diem, K., McDonald, D., Vazquez, J., Cao, J., Ohlen, C., McElrath, M. J., Picker, L. & Corey, L., Feb 16 2010, In : Retrovirology. 7, 12.

Research output: Contribution to journalArticle

Macaca mulatta
Gastrointestinal Tract
T-Lymphocytes
Lymphoid Tissue
Ileum
2009
499 Citations (Scopus)

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

Hansen, S., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J., Jarvis, M. A. & Picker, L., Mar 2009, In : Nature Medicine. 15, 3, p. 293-299 7 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
T-cells
Macaca mulatta
Viruses
Cytomegalovirus
1 Citation (Scopus)

Erratum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge (Nature Medicine (2009) 15 (293-299))

Hansen, S., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J., Jarvis, M. A. & Picker, L., Apr 2009, In : Nature Medicine. 15, 4, p. 462 1 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Macaca mulatta
Medicine
T-Lymphocytes
42 Citations (Scopus)

IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment

Leone, A., Picker, L. & Sodora, D. L., 2009, In : Current HIV Research. 7, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

Interleukin-15
Interleukin-7
Interleukin-2
Vaccination
HIV
55 Citations (Scopus)

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

Okoye, A., Park, H., Rohankhedkar, M., Coyne-Johnson, L., Lum, R., Walker, J. M., Planer, S. L., Legasse, A. W., Sylwester, A., Piatak, M., Lifson, J. D., Sodora, D. L., Villinger, F., Axthelm, M., Schmitz, J. E. & Picker, L., Jul 6 2009, In : Journal of Experimental Medicine. 206, 7, p. 1575-1588 14 p.

Research output: Contribution to journalArticle

Lymphocyte Depletion
Simian Immunodeficiency Virus
T-Lymphocytes
Virus Diseases
Macaca mulatta
62 Citations (Scopus)

The transfer of adaptive immunity to CMVduring hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor

Scheinberg, P., Melenhorst, J. J., Brenchley, J. M., Hill, B. J., Hensel, N. F., Chattopadhyay, P. K., Roederer, M., Picker, L., Price, D. A., Barrett, A. J. & Douek, D. C., Dec 3 2009, In : Blood. 114, 24, p. 5071-5080 10 p.

Research output: Contribution to journalArticle

T-cells
Hematopoietic Stem Cell Transplantation
Adaptive Immunity
Stem cells
Cytomegalovirus
2008
27 Citations (Scopus)

Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques

Price, D. A., Bitmansour, A. D., Edgar, J. B., Walker, J. M., Axthelm, M., Douek, D. C. & Picker, L., Jan 1 2008, In : Journal of Immunology. 180, 1, p. 269-280 12 p.

Research output: Contribution to journalArticle

Macaca mulatta
Cytomegalovirus
T-Lymphocytes
Infection
Population Dynamics
16 Citations (Scopus)

Pathogenic mechanisms in simian immunodeficiency virus infection

Grossman, Z. & Picker, L., May 2008, In : Current Opinion in HIV and AIDS. 3, 3, p. 380-386 7 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
T-Lymphocytes
Infection
Clinical Competence
49 Citations (Scopus)

Replication in a superficial epithelial cell niche explains the lack of pathogenicity of primate foamy virus infections

Murray, S. M., Picker, L., Axthelm, M., Hudkins, K., Alpers, C. E. & Linial, M. L., Jun 2008, In : Journal of Virology. 82, 12, p. 5981-5985 5 p.

Research output: Contribution to journalArticle

Spumavirus
Virus Diseases
Primates
Virulence
niches
2007
95 Citations (Scopus)

Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates

Čičin-Šain, L., Messaoudi, I., Park, B., Currier, N., Planer, S., Fischer, M., Tackitt, S., Nikolich-Žugich, D., Legasse, A., Axthelm, M., Picker, L., Mori, M. T. & Nikolich-Žugich, J., Dec 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 50, p. 19960-19965 6 p.

Research output: Contribution to journalArticle

Primates
T-Lymphocytes
Cell Aging
Macaca mulatta
Maintenance

Erratum: Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection (Journal of Experimental Medicine (September 3, 2007) 204, 9, (2171-2185))

Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A., Piatak, M., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M., Grossman, Z. & Picker, L., Oct 1 2007, In : Journal of Experimental Medicine. 204, 10, p. 2493 1 p.

Research output: Contribution to journalArticle

Biomedical Research
Chronic Disease
T-Lymphocytes
Infection
199 Citations (Scopus)

Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection

Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A., Piatak, M., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M., Grossman, Z. & Picker, L., Sep 3 2007, In : Journal of Experimental Medicine. 204, 9, p. 2171-2185 15 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Chronic Disease
T-Lymphocytes
Acquired Immunodeficiency Syndrome
57 Citations (Scopus)

Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys

Pereira, L. E., Villinger, F., Onlamoon, N., Bryan, P., Cardona, A., Pattanapanysat, K., Mori, K., Hagen, S., Picker, L. & Ansari, A. A., May 2007, In : Journal of Virology. 81, 9, p. 4445-4456 12 p.

Research output: Contribution to journalArticle

Cercocebus atys
Cercocebus
Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virus Diseases
2006
41 Citations (Scopus)

Anti-OX40 (CD134) administration to nonhuman primates: Immunostimulatory effects and toxicokinetic study

Weinberg, A. D., Thalhofer, C., Morris, N., Walker, J. M., Seiss, D., Wong, S., Axthelm, M., Picker, L. & Urba, W. J., Nov 2006, In : Journal of Immunotherapy. 29, 6, p. 575-585 11 p.

Research output: Contribution to journalArticle

Primates
Haplorhini
Splenomegaly
Macaca mulatta
Anti-Idiotypic Antibodies
152 Citations (Scopus)

Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates

Messaoudi, I., Warner, J., Fischer, M., Park, B., Hill, B., Mattison, J., Lane, M. A., Roth, G. S., Ingram, D. K., Picker, L., Douek, D. C., Mori, M. T. & Nikolich-Žugich, J., Dec 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 51, p. 19448-19453 6 p.

Research output: Contribution to journalArticle

Caloric Restriction
Cell Aging
Primates
T-Lymphocytes
Communicable Diseases
57 Citations (Scopus)

Expanded tissue targets for foamy virus replication with simian immunodeficiency virus-induced immunosuppression

Murray, S. M., Picker, L., Axthelm, M. & Linial, M. L., Jan 2006, In : Journal of Virology. 80, 2, p. 663-670 8 p.

Research output: Contribution to journalArticle

Spumavirus
Simian immunodeficiency virus
Simian Immunodeficiency Virus
immunosuppression
Virus Replication
135 Citations (Scopus)

IL-15 induces CD4+ effector memory T cell production and tissue emigration in nonhuman primates

Picker, L., Reed-Inderbitzin, E. F., Hagen, S. I., Edgar, J. B., Hansen, S., Legasse, A., Planer, S., Piatak, M., Lifson, J. D., Maino, V. C., Axthelm, M. & Villinger, F., Jun 1 2006, In : Journal of Clinical Investigation. 116, 6, p. 1514-1524 11 p.

Research output: Contribution to journalArticle

Interleukin-15
Emigration and Immigration
Primates
T-Lymphocytes
T-Lymphoid Precursor Cells
116 Citations (Scopus)

Immunopathogenesis of acute AIDS virus infection

Picker, L., Aug 2006, In : Current Opinion in Immunology. 18, 4, p. 399-405 7 p.

Research output: Contribution to journalArticle

Virus Diseases
Acquired Immunodeficiency Syndrome
HIV
T-Lymphocytes
Opportunistic Infections

Introduction

Veazey, R. S. & Picker, L., Aug 2006, In : Journal of Medical Primatology. 35, 4-5, p. 177 1 p.

Research output: Contribution to journalArticle

2201 Citations (Scopus)

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., Blazar, B. R., Rodriguez, B., Teixeira-Johnson, L., Landay, A., Martin, J. N., Hecht, F. M., Picker, L., Lederman, M. M., Deeks, S. G. & Douek, D. C., Dec 2006, In : Nature Medicine. 12, 12, p. 1365-1371 7 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
HIV Infections
Lipopolysaccharides
Cercocebus atys
Chemical activation
303 Citations (Scopus)

Pathogenesis of HIV infection: What the virus spares is as important as what it destroys

Grossman, Z., Meier-Schellersheim, M., Paul, W. E. & Picker, L., Mar 2006, In : Nature Medicine. 12, 3, p. 289-295 7 p.

Research output: Contribution to journalArticle

T-cells
Viruses
HIV Infections
Immune system
Chemical activation
196 Citations (Scopus)

Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection

Estes, J., Li, Q., Reynolds, M. R., Wietgrefe, S., Duan, L., Schacker, T., Picker, L., Watkins, D. I., Lifson, J. D., Reilly, C., Carlis, J. & Haase, A. T., Mar 1 2006, In : Journal of Infectious Diseases. 193, 5, p. 703-712 10 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Regulatory T-Lymphocytes
Immunosuppressive Agents
Cytomegalovirus Infections
186 Citations (Scopus)

Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239

Wilson, N. A., Reed, J., Napoe, G. S., Piaskowski, S., Szymanski, A., Furlott, J., Gonzalez, E. J., Yant, L. J., Maness, N. J., May, G. E., Soma, T., Reynolds, M. R., Rakasz, E., Rudersdorf, R., McDermott, A. B., O'Connor, D. H., Friedrich, T. C., Allison, D. B., Patki, A., Picker, L. & 13 others, Burton, D. R., Lin, J., Huang, L., Patel, D., Heindecker, G., Fan, J., Citron, M., Horton, M., Wang, F., Liang, X., Shiver, J. W., Casimiro, D. R. & Watkins, D. I., Jun 2006, In : Journal of Virology. 80, 12, p. 5875-5885 11 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Cellular Immunity
cell-mediated immunity
Vaccines
2005
831 Citations (Scopus)

Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects

Sylwester, A., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., Nelson, J. & Picker, L., Sep 5 2005, In : Journal of Experimental Medicine. 202, 5, p. 673-685 13 p.

Research output: Contribution to journalArticle

Cytomegalovirus
T-Lymphocytes
Open Reading Frames
Viruses
Cytomegalovirus Infections
12 Citations (Scopus)

Clinical, microbiological, and immunological characteristics in HIV-infected subjects at risk for disseminated Mycobacterium avium complex disease: An AACTG Study

MacGregor, R. R., Hafner, R., Wu, J. W., Murphy, R. L., Perlman, D. C., Bermudez, L. E., Inderlied, C. B., Picker, L., Wallis, R. S., Andersen, J. W., Mahon, L. F., Koletar, S. L. & Peterson, D. M., Aug 2005, In : AIDS Research and Human Retroviruses. 21, 8, p. 689-695 7 p.

Research output: Contribution to journalArticle

Mycobacterium avium Complex
HIV
CD4 Lymphocyte Count
Bone Marrow
Opportunistic Infections
1 Citation (Scopus)

Erratum: (The Journal of Experimental Medicine (September 5, 2005) 202:5 (673-685))

Sylwester, A., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., Nelson, J. & Picker, L., Nov 7 2005, In : Journal of Experimental Medicine. 202, 9, p. 1301 1 p.

Research output: Contribution to journalArticle

Biomedical Research
77 Citations (Scopus)

HIV pathogenesis: The first cut is the deepest

Picker, L. & Watkins, D. I., 2005, In : Nature Immunology. 6, 5, p. 430-432 3 p.

Research output: Contribution to journalArticle

HIV Infections
Immune System
Immunity
Acquired Immunodeficiency Syndrome
HIV
2004
17 Citations (Scopus)

An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory

Saavedra-Lozano, J., Cao, Y., Callison, J., Sarode, R., Sodora, D., Edgar, J., Hatfield, J., Picker, L., Peterson, D., Ramilo, O. & Vitetta, E. S., Feb 22 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 8, p. 2494-2499 6 p.

Research output: Contribution to journalArticle

Immunotoxins
Highly Active Antiretroviral Therapy
HIV
T-Lymphocytes
Viremia
103 Citations (Scopus)

A Sound Rationale Needed for Phase III HIV-1 Vaccine Trials

Burton, D. R., Desrosiers, R. C., Doms, R. W., Feinberg, M. B., Gallo, R. C., Hahn, B., Hoxie, J. A., Hunter, E., Korber, B., Landay, A., Lederman, M. M., Lieberman, J., McCune, J. M., Moore, J. P., Nathanson, N., Picker, L., Richman, D., Rinaldo, C., Stevenson, M., Watkins, D. I. & 2 others, Wolinsky, S. M. & Zack, J. A., Jan 16 2004, In : Science. 303, 5656, p. 316 1 p.

Research output: Contribution to journalArticle

HIV Envelope Protein gp120
Immunization Schedule
Secondary Immunization
AIDS Vaccines
Phase III Clinical Trials
250 Citations (Scopus)

Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection

Picker, L., Hagen, S. I., Lum, R., Reed-Inderbitzin, E. F., Daly, L. M., Sylwester, A., Walker, J. M., Siess, D. C., Piatak, M., Wang, C., Allison, D. B., Maino, V. C., Lifson, J. D., Kodama, T. & Axthelm, M., Nov 15 2004, In : Journal of Experimental Medicine. 200, 10, p. 1299-1314 16 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
T-Lymphocytes
Macaca mulatta
Infection
19 Citations (Scopus)

Support for the RV144 HIV vaccine trial [1] (multiple letters)

Belshe, R., Franchini, G., Girard, M. P., Gotch, F., Kaleebu, P., Marthas, M. L., McChesney, M. B., McCullough, R., Mhalu, F., Salmon-Ceron, D., Sekaly, R. P., Van Rompay, K., Verrier, B., Wahren, B., Weissenbacher, M., Baehr, M., Cappiello, D., Collins, C., Gold, D., Kaleebu, P. & 32 others, Menezes, A., Powell, M., Reinhard, R., Santiago, L., Snow, B., Thomas, J., Wakefield, S., Warren, M., Lee, E., Collins, H., Burton, D. R., Desrosiers, R. C., Doms, R. W., Feinberg, M. B., Hahn, B. H., Hoxie, J. A., Hunter, E., Korber, B. T. M., Landay, A. L., Lederman, M. M., Lieberman, J., McCune, J. M., Moore, J. P., Nathanson, N., Picker, L., Richman, D. D., Rinaldo, C. R., Stevenson, M., Watkins, D. I., Wolinsky, S. M., Zack, J. A. & Gallo, R. C., Jul 9 2004, In : Science. 305, 5681, p. 177-180 4 p.

Research output: Contribution to journalArticle

AIDS Vaccines
2003
131 Citations (Scopus)

Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses

O'Connor, D. H., Mothe, B. R., Weinfurter, J. T., Fuenger, S., Rehrauer, W. M., Jing, P., Rudersdorf, R. R., Liebl, M. E., Krebs, K., Vasquez, J., Dodds, E., Loffredo, J., Martin, S., McDermott, A. B., Allen, T. M., Wang, C., Doxiadis, G. G., Montefiori, D. C., Hughes, A., Burton, D. R. & 5 others, Allison, D. B., Wolinsky, S. M., Bontrop, R., Picker, L. & Watkins, D. I., Aug 2003, In : Journal of Virology. 77, 16, p. 9029-9040 12 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
cytotoxic T-lymphocytes
major histocompatibility complex
Cytotoxic T-Lymphocytes
55 Citations (Scopus)

Mapping T cell epitopes by flow cytometry

Hoffmeister, B., Kiecker, F., Tesfa, L., Volk, H. D., Picker, L. & Kern, F., Mar 1 2003, In : Methods. 29, 3, p. 270-281 12 p.

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Flow cytometry
T-cells
Flow Cytometry
Peptides
413 Citations (Scopus)

T cell dynamics in HIV-1 infection

Douek, D. C., Picker, L. & Koup, R. A., 2003, In : Annual Review of Immunology. 21, p. 265-304 40 p.

Research output: Contribution to journalArticle

HIV Infections
HIV-1
T-Lymphocytes
Immune System
Lymphoid Tissue
2002
10 Citations (Scopus)

Analysis of the immune response and viral evolution during the acute phase of SIV infection

Horton, H., Vogel, T., O'Connor, D., Picker, L. & Watkins, D. I., May 6 2002, In : Vaccine. 20, 15, p. 1927-1932 6 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virus Diseases
T-lymphocytes
Human immunodeficiency virus
18 Citations (Scopus)

An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive persons

Saavedra-Lozano, J., McCoig, C., Xu, J., Cao, Y., Keiser, P., Ghetie, V., Siliciano, R. F., Siliciano, J. D., Picker, L., Ramilo, O. & Vitetta, E. S., Feb 1 2002, In : Journal of Infectious Diseases. 185, 3, p. 306-314 9 p.

Research output: Contribution to journalArticle

Immunotoxins
HIV
T-Lymphocytes
Viremia
Highly Active Antiretroviral Therapy
204 Citations (Scopus)

Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals

Kern, F., Bunde, T., Faulhaber, N., Kiecker, F., Khatamzas, E., Rudawski, I. M., Pruss, A., Gratama, J. W., Volkmer-Engert, R., Ewert, R., Reinke, P., Volk, H. D. & Picker, L., Jun 15 2002, In : Journal of Infectious Diseases. 185, 12, p. 1709-1716 8 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Phosphoproteins
T-Lymphocytes
Peptides
Proteins
382 Citations (Scopus)

Development and homeostasis of T cell memory in rhesus macaque

Pitcher, C. J., Hagen, S. I., Walker, J. M., Lum, R., Mitchell, B. L., Maino, V. C., Axthelm, M. & Picker, L., Jan 1 2002, In : Journal of Immunology. 168, 1, p. 29-43 15 p.

Research output: Contribution to journalArticle

Macaca mulatta
Homeostasis
T-Lymphocytes
T-Lymphocyte Subsets
Lymph
34 Citations (Scopus)

Differences between T cell epitopes recognized after immunization and after infection

Vogel, T. U., Horton, H., Fuller, D. H., Carter, D. K., Vielhuber, K., O'Connor, D. H., Shipley, T., Fuller, J., Sutter, G., Erfle, V., Wilson, N., Picker, L. & Watkins, D. I., Oct 15 2002, In : Journal of Immunology. 169, 8, p. 4511-4521 11 p.

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Epitopes
Immunization
Infection
Vaccination
59 Citations (Scopus)

Direct Ex vivo analysis of human CD4+ memory T cell activation requirements at the single clonotype level

Bitmansour, A. D., Douek, D. C., Maino, V. C. & Picker, L., Aug 1 2002, In : Journal of Immunology. 169, 3, p. 1207-1218 12 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Peptides
Interleukin-2
Epitopes
Cell Differentiation
113 Citations (Scopus)

Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection

Mothé, B. R., Horton, H., Carter, D. K., Allen, T. M., Liebl, M. E., Skinner, P., Vogel, T. U., Fuenger, S., Vielhuber, K., Rehrauer, W., Wilson, N., Franchini, G., Altman, J. D., Haase, A., Picker, L., Allison, D. B. & Watkins, D. I., 2002, In : Journal of Virology. 76, 2, p. 875-884 10 p.

Research output: Contribution to journalArticle

Macaca
major histocompatibility complex
Cytotoxic T-Lymphocytes
Virus Diseases
Major Histocompatibility Complex
169 Citations (Scopus)

Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239

Horton, H., Vogel, T. U., Carter, D. K., Vielhuber, K., Fuller, D. H., Shipley, T., Fuller, J. T., Kunstman, K. J., Sutter, G., Montefiori, D. C., Erfle, V., Desrosiers, R. C., Wilson, N., Picker, L., Wolinsky, S. M., Wang, C., Allison, D. B. & Watkins, D. I., Jul 2002, In : Journal of Virology. 76, 14, p. 7187-7202 16 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Vaccinia virus
virus replication
Macaca mulatta
18 Citations (Scopus)

Skewed maturation of virus-specific CTLs?

Gamadia, L. E., Ten Berge, I. J. M., Picker, L. & Van Lier, R. A. W., 2002, In : Nature Immunology. 3, 3, p. 203 1 p.

Research output: Contribution to journalArticle

Immunologic Memory
Immunophenotyping
Cytotoxic T-Lymphocytes
HIV
Viruses
2001
593 Citations (Scopus)

Analysis of total human immunodeficiency virus (HIV)-specific CD4+ and CD8+ T-cell responses: Relationship to viral load in untreated HIV infection

Betts, M. R., Ambrozak, D. R., Douek, D. C., Bonhoeffer, S., Brenchley, J. M., Casazza, J. P., Koup, R. A. & Picker, L., 2001, In : Journal of Virology. 75, 24, p. 11983-11991 9 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus
HIV infections
Virus Diseases
viral load
Viral Load
88 Citations (Scopus)

CD4+CD8dim T lymphocytes exhibit enhanced cytokine expression, proliferation and cytotoxic activity in response to HCMV and HIV-1 antigens

Suni, M. A., Ghanekar, S. A., Houck, D. W., Maecker, H. T., Wormsley, S. B., Picker, L., Moss, R. B. & Maino, V. C., 2001, In : European Journal of Immunology. 31, 8, p. 2512-2520 9 p.

Research output: Contribution to journalArticle

HIV Antigens
HIV-1
Cytokines
T-Lymphocytes
Population
86 Citations (Scopus)

Clonotypic structure of the human CD4+ memory T cell response to cytomegalovirus

Bitmansour, A. D., Waldrop, S. L., Pitcher, C. J., Khatamzas, E., Kern, F., Maino, V. C. & Picker, L., Aug 1 2001, In : Journal of Immunology. 167, 3, p. 1151-1163 13 p.

Research output: Contribution to journalArticle

Cytomegalovirus
T-Lymphocytes
Epitopes
Immunologic Monitoring
Phosphoproteins