• 29038 Citations
  • 82 h-Index
1976 …2021
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Research Output 1979 2019

  • 29038 Citations
  • 82 h-Index
  • 198 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Chapter
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Article
2019

Acute infection and subsequent subclinical reactivation of herpes simplex virus 2 after vaginal inoculation of rhesus macaques

Lo, M., Zhu, J., Hansen, S., Carroll, T., Zuend, C. F., Nöel-Romas, L., Ma, Z. M., Fritts, L., Huang, M. L., Sun, S., Huang, Y., Koelle, D. M., Picker, L., Burgener, A., Corey, L. & Miller, C. J., Jan 1 2019, In : Journal of Virology. 93, 2, e01574-18.

Research output: Contribution to journalArticle

Human herpesvirus 2
Asymptomatic Infections
Human Herpesvirus 2
Macaca mulatta
infection
3 Citations (Scopus)

Cytomegalovirus vectors expressing Plasmodium knowlesi antigens induce immune responses that delay parasitemia upon sporozoite challenge

Hansen, S., Womack, J., Scholz, I., Renner, A., Edgel, K. A., Xu, G., Ford, J. C., Grey, M., St. Laurent, B., Turner, J. M., Planer, S., Legasse, A. W., Richie, T. L., Aguiar, J. C., Axthelm, M., Villasante, E. D., Weiss, W., Edlefsen, P. T., Picker, L. & Frueh, K., Jan 1 2019, In : PLoS One. 14, 1, e0210252.

Research output: Contribution to journalArticle

Plasmodium knowlesi
Cytomegalovirus
Sporozoites
T-cells
Parasitemia
2 Citations (Scopus)

Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Marshall, E., Malouli, D., Hansen, S., Gilbride, R. M., Hughes, C. M., Ventura, A. B., Ainslie, E., Selseth, A. N., Ford, J. C., Burke, D., Kreklywich, C. N., Womack, J., Legasse, A. W., Axthelm, M., Kahl, C., Streblow, D., Edlefsen, P. T., Picker, L. & Frueh, K., Jul 17 2019, In : Science Translational Medicine. 11, 501, eaaw2603.

Research output: Contribution to journalArticle

Cytomegalovirus Vaccines
Cytomegalovirus
Immunity
Safety
Leukocyte Transfusion

Identification and functional characterization of a novel Fc gamma-binding glycoprotein in rhesus cytomegalovirus

Kolb, P., Sijmons, S., McArdle, M. R., Taher, H., Womack, J., Hughes, C., Ventura, A., Jarvis, M. A., Stahl-Hennig, C., Hansen, S., Picker, L., Malouli, D., Hengel, H. & Frueh, K., Feb 1 2019, In : Journal of virology. 93, 4, e0207718.

Research output: Contribution to journalArticle

Cytomegalovirus
glycoproteins
Glycoproteins
Immunoglobulin G
Human herpesvirus 5
1 Citation (Scopus)

Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome

GC6-74 Consortium, Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Tuberculosis
Metabolomics
Transfer RNA Aminoacylation
Metabolome
Transcriptome
2 Citations (Scopus)

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

Bender, A. M., Simonetti, F. R., Kumar, M. R., Fray, E. J., Bruner, K. M., Timmons, A. E., Tai, K. Y., Jenike, K. M., Antar, A. A. R., Liu, P. T., Ho, Y. C., Raugi, D. N., Seydi, M., Gottlieb, G. S., Okoye, A., Del Prete, G. Q., Picker, L., Mankowski, J. L., Lifson, J. D., Siliciano, J. D. & 4 others, Laird, G. M., Barouch, D. H., Clements, J. E. & Siliciano, R. F., Jul 10 2019, In : Cell Host and Microbe. 26, 1, p. 73-85.e4

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
HIV-2
Viral Genome
HIV Infections
Genome

Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+ T Cells in Nonhuman Primates

Abdulhaqq, S. A., Wu, H., Schell, J. B., Hammond, K. B., Reed, J. S., Legasse, A. W., Axthelm, M., Park, B., Asokan, A., Frueh, K., Hansen, S., Picker, L. & Sacha, J., Oct 1 2019, In : Journal of virology. 93, 19

Research output: Contribution to journalArticle

Antigen Presentation
major histocompatibility complex
Major Histocompatibility Complex
Primates
transporters
2018
6 Citations (Scopus)

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Okoye, A., Hansen, S., Vaidya, M., Fukazawa, Y., Park, H., Duell, D. M., Lum, R., Hughes, C. M., Ventura, A. B., Ainslie, E., Ford, J. C., Morrow, D., Gilbride, R. M., Legasse, A. W., Hesselgesser, J., Geleziunas, R., Li, Y., Oswald, K., Shoemaker, R., Fast, R. & 6 others, Bosche, W. J., Borate, B. R., Edlefsen, P. T., Axthelm, M., Picker, L. & Lifson, J. D., Sep 1 2018, In : Nature Medicine. 24, 9, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Secondary Prevention
Viruses
Cytomegalovirus
Macaca mulatta
4 Citations (Scopus)

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

Thompson, H. L., Smithey, M. J., Uhrlaub, J. L., Jeftić, I., Jergović, M., White, S. E., Currier, N., Lang, A. M., Okoye, A., Park, B., Picker, L., Surh, C. D. & Nikolich-Žugich, J., Jan 1 2018, (Accepted/In press) In : Aging Cell. e12865.

Research output: Contribution to journalArticle

Rejuvenation
Primates
Lymph Nodes
T-Lymphocytes
Fibroblast Growth Factor 7
7 Citations (Scopus)

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Walters, L. C., Harlos, K., Brackenridge, S., Rozbesky, D., Barrett, J. R., Jain, V., Walter, T. S., O’Callaghan, C. A., Borrow, P., Toebes, M., Hansen, S., Sacha, J., Abdulhaqq, S., Greene, J. M., Frueh, K., Marshall, E., Picker, L., Jones, E. Y., McMichael, A. J. & Gillespie, G. M., Dec 1 2018, In : Nature Communications. 9, 1, 3137.

Research output: Contribution to journalArticle

leukocytes
pathogens
antigens
Pathogens
HLA Antigens
4 Citations (Scopus)

Potent immune modulation by medi6383, an engineered human ox40 ligand igg4p fc fusion protein

Oberst, M. D., Auge, C., Morris, C., Kentner, S., Mulgrew, K., McGlinchey, K., Hair, J., Hanabuchi, S., Du, Q., Damschroder, M., Feng, H., Eck, S., Buss, N., de Haan, L., Pierce, A. J., Park, H., Sylwester, A., Axthelm, M., Picker, L., Morris, N. P. & 2 others, Weinberg, A. & Hammond, S. A., May 1 2018, In : Molecular Cancer Therapeutics. 17, 5, p. 1024-1038 15 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Proteins
Cell Proliferation
Neoplasms
Cytokines
48 Citations (Scopus)

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

Hansen, S., Zak, D. E., Xu, G., Ford, J. C., Marshall, E., Malouli, D., Gilbride, R. M., Hughes, C. M., Ventura, A. B., Ainslie, E., Randall, K. T., Selseth, A. N., Rundstrom, P., Herlache, L., Lewis, M. S., Park, H., Planer, S. L., Turner, J. M., Fischer, M., Armstrong, C. & 20 others, Zweig, R. C., Valvo, J., Braun, J. M., Shankar, S., Lu, L., Sylwester, A., Legasse, A. W., Messerle, M., Jarvis, M. A., Amon, L. M., Aderem, A., Alter, G., Laddy, D. J., Stone, M., Bonavia, A., Evans, T. G., Axthelm, M., Frueh, K., Edlefsen, P. T. & Picker, L., Feb 1 2018, In : Nature Medicine. 24, 2, p. 130-143 14 p.

Research output: Contribution to journalArticle

Cytomegalovirus Vaccines
Macaca mulatta
Tuberculosis
Vaccines
Tissue
11 Citations (Scopus)

The Role of MHC-E in T Cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques

Wu, H. L., Wiseman, R. W., Hughes, C. M., Webb, G. M., Abdulhaqq, S. A., Bimber, B. N., Hammond, K. B., Reed, J. S., Gao, L., Burwitz, B., Greene, J. M., Ferrer, F., Legasse, A. W., Axthelm, M., Park, B., Brackenridge, S., Maness, N. J., McMichael, A. J., Picker, L., O'Connor, D. H. & 2 others, Hansen, S. & Sacha, J., Jan 1 2018, In : Journal of Immunology. 200, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

Macaca
Macaca mulatta
Immunity
T-Lymphocytes
Peptides
2017
10 Citations (Scopus)

Human cytomegalovirus induces cellular and humoral virus-specific immune responses in humanized BLT mice

Crawford, L. B., Tempel, R., Streblow, D., Kreklywich, C., Smith, P., Picker, L., Nelson, J. & Caposio, P., Dec 1 2017, In : Scientific Reports. 7, 1, 937.

Research output: Contribution to journalArticle

Cytomegalovirus
Viruses
Virus Latency
Thymus Gland
Bone Marrow
28 Citations (Scopus)

MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates

Greene, J. M., Dash, P., Roy, S., McMurtrey, C., Awad, W., Reed, J. S., Hammond, K. B., Abdulhaqq, S., Wu, H. L., Burwitz, B., Roth, B. F., Morrow, D. W., Ford, J. C., Xu, G., Bae, J. Y., Crank, H., Legasse, A. W., Dang, T. H., Greenaway, H. Y., Kurniawan, M. & 14 others, Gold, M., Harriff, M., Lewinsohn, D., Park, B., Axthelm, M., Stanton, J., Hansen, S., Picker, L., Venturi, V., Hildebrand, W., Thomas, P. G., Lewinsohn, D., Adams, E. J. & Sacha, J., May 1 2017, In : Mucosal Immunology. 10, 3, p. 802-813 12 p.

Research output: Contribution to journalArticle

Primates
Macaca
Vaccination
Infection
Ligands
2016
19 Citations (Scopus)

Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion

Ranasinghe, S., Lamothe, P. A., Soghoian, D. Z., Kazer, S. W., Cole, M. B., Shalek, A. K., Yosef, N., Jones, R. B., Donaghey, F., Nwonu, C., Jani, P., Clayton, G. M., Crawford, F., White, J., Montoya, A., Power, K., Allen, T. M., Streeck, H., Kaufmann, D. E., Picker, L. & 2 others, Kappler, J. W. & Walker, B. D., Oct 18 2016, In : Immunity. 45, 4, p. 917-930 14 p.

Research output: Contribution to journalArticle

HLA Antigens
HIV Infections
Antiviral Agents
Major Histocompatibility Complex
T-Lymphocytes
111 Citations (Scopus)

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

Hansen, S., Wu, H. L., Burwitz, B., Hughes, C. M., Hammond, K. B., Ventura, A. B., Reed, J. S., Gilbride, R. M., Ainslie, E., Morrow, D. W., Ford, J. C., Selseth, A. N., Pathak, R., Malouli, D., Legasse, A. W., Axthelm, M., Nelson, J., Gillespie, G. M., Walters, L. C., Brackenridge, S. & 8 others, Sharpe, H. R., López, C. A., Frueh, K., Korber, B. T., McMichael, A. J., Gnanakaran, S., Sacha, J. & Picker, L., Feb 12 2016, In : Science. 351, 6274, p. 714-720 7 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
T-Lymphocytes
Natural Killer Cells
Epitopes
Immune Evasion
12 Citations (Scopus)

Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques

Burwitz, B., Malouli, D., Bimber, B. N., Reed, J. S., Ventura, A. B., Hancock, M., Uebelhoer, L. S., Bhusari, A., Hammond, K. B., Espinosa Trethewy, R. G., Klug, A., Legasse, A. W., Axthelm, M., Nelson, J., Park, B., Streblow, D., Hansen, S., Picker, L., Frueh, K. & Sacha, J., Nov 1 2016, In : PLoS Pathogens. 12, 11, e1006014.

Research output: Contribution to journalArticle

Cytomegalovirus Infections
Macaca
Cytomegalovirus
Primates
Tropism
12 Citations (Scopus)

Effect of anti-IL-15 administration on T Cell and NK cell homeostasis in rhesus macaques

Degottardi, M. Q., Okoye, A., Vaidya, M., Talla, A., Konfe, A. L., Reyes, M. D., Clock, J. A., Duell, D. M., Legasse, A. W., Sabnis, A., Park, B., Axthelm, M., Estes, J., Reiman, K. A., Sekaly, R. P. & Picker, L., Aug 15 2016, In : Journal of Immunology. 197, 4, p. 1183-1198 16 p.

Research output: Contribution to journalArticle

Interleukin-15
Macaca mulatta
Natural Killer Cells
Homeostasis
T-Lymphocytes
8 Citations (Scopus)

Epigraph: A vaccine design tool applied to an HIV therapeutic vaccine and a pan-filovirus vaccine

Theiler, J., Yoon, H., Yusim, K., Picker, L., Frueh, K. & Korber, B., Oct 5 2016, In : Scientific Reports. 6, 33987.

Research output: Contribution to journalArticle

AIDS Vaccines
Vaccines
Antigens
Epitopes
Therapeutics
1 Citation (Scopus)

In situ staining and laser capture microdissection of lymph node residing SIV Gag-specific CD8+ T cells - A tool to interrogate a functional immune response ex vivo

Tjernlund, A., Burgener, A., Lindvall, J. M., Peng, T., Zhu, J., Öhrmalm, L., Picker, L., Broliden, K., McElrath, M. J. & Corey, L., Mar 1 2016, In : PLoS One. 11, 3, e0149907.

Research output: Contribution to journalArticle

Microdissection
Laser Capture Microdissection
T-cells
lasers
lymph nodes
11 Citations (Scopus)

Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus

Sturgill, E. R., Malouli, D., Hansen, S., Burwitz, B., Seo, S., Schneider, C. L., Womack, J. L., Verweij, M., Ventura, A. B., Bhusari, A., Jeffries, K. M., Legasse, A. W., Axthelm, M., Hudson, A. W., Sacha, J., Picker, L. & Frueh, K., Aug 1 2016, In : PLoS Pathogens. 12, 8, e1005868.

Research output: Contribution to journalArticle

Cytomegalovirus Infections
Natural Killer Cells
Cytomegalovirus
Infection
Natural Killer Cell Receptors
2015
14 Citations (Scopus)

A new perspective of the structural complexity of HCMV-specific T-cell responses

Sylwester, A., Nambiar, K. Z., Caserta, S., Klenerman, P., Picker, L. & Kern, F., Nov 6 2015, (Accepted/In press) In : Mechanisms of Ageing and Development.

Research output: Contribution to journalArticle

T-Lymphocytes
Social Dominance
Protein Subunits
Organ Transplantation
Infection
231 Citations (Scopus)

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

Fukazawa, Y., Lum, R., Okoye, A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., Morcock, D., Swanson, T., Legasse, A. W., Axthelm, M., Hesselgesser, J., Geleziunas, R., Hirsch, V. M., Edlefsen, P. T., Piatak, M., Estes, J. & 2 others, Lifson, J. D. & Picker, L., 2015, In : Nature Medicine. 21, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Viruses
B-Lymphocytes
T-cells
12 Citations (Scopus)

Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques

Okoye, A., Rohankhedkar, M., Konfe, A. L., Abana, C. O., Reyes, M. D., Clock, J. A., Duell, D. M., Sylwester, A., Sammader, P., Legasse, A. W., Park, B., Axthelm, M., Nikolich-Žugich, J. & Picker, L., Nov 1 2015, In : Journal of Immunology. 195, 9, p. 4292-4305 14 p.

Research output: Contribution to journalArticle

Interleukin-7
Macaca mulatta
Homeostasis
T-Lymphocytes
Therapeutics
3 Citations (Scopus)

HIV: Seeking ultimate victory

Picker, L. & Lifson, J. D., Jan 15 2015, In : Nature. 517, 7534, p. 281-282 2 p.

Research output: Contribution to journalArticle

Virus Latency
Dominant Genes
Viral Genes
Cytotoxic T-Lymphocytes
HIV-1
15 Citations (Scopus)

Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance

Yang, O. O., Ali, A., Kasahara, N., Faure-Kumar, E., Bae, J. Y., Picker, L. & Park, H., 2015, In : Journal of Virology. 89, 2, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

conserved sequences
Conserved Sequence
Human immunodeficiency virus 1
HIV-1
Vaccines
22 Citations (Scopus)

Vaccine-induced linear epitope-specific antibodies to simian immunodeficiency virus SIVmac239 envelope are distinct from those induced to the human immunodeficiency virus type 1 envelope in nonhuman primates

Shen, X., Duffy, R., Howington, R., Cope, A., Sadagopal, S., Park, H., Pal, R., Kwa, S., Ding, S., Yang, O. O., Fouda, G. G., Grand, R. L., Bolton, D., Esteban, M., Phogat, S., Roederer, M., Amara, R. R., Picker, L., Seder, R. A., Juliana McElrath, M. & 10 others, Barnett, S., Permar, S. R., Shattock, R., DeVico, A. L., Felber, B. K., Pavlakis, G. N., Pantaleo, G., Korber, B. T., Montefiori, D. C. & Tomaras, G. D., 2015, In : Journal of Virology. 89, 16, p. 8643-8650 8 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Human immunodeficiency virus 1
Primates
epitopes
2014
7 Citations (Scopus)

Are effector memory T cells the key to an effective HIV/AIDS vaccine?

Picker, L., 2014, In : EMBO Reports. 15, 8, p. 820-821 2 p.

Research output: Contribution to journalArticle

AIDS Vaccines
T-cells
Animals
Data storage equipment
17 Citations (Scopus)

Cytomegalovirus pp65 limits dissemination but is dispensable for persistence

Malouli, D., Hansen, S., Nakayasu, E. S., Marshall, E., Hughes, C. M., Ventura, A. B., Gilbride, R. M., Lewis, M. S., Xu, G., Kreklywich, C., Whizin, N., Fischer, M., Legasse, A. W., Viswanathan, K., Siess, D., Camp, D. G., Axthelm, M., Kahl, C., De Filippis, V., Smith, R. D. & 3 others, Streblow, D., Picker, L. & Frueh, K., 2014, In : Journal of Clinical Investigation. 124, 5, p. 1928-1944 17 p.

Research output: Contribution to journalArticle

Phosphoproteins
Infection
T-Lymphocytes
Virion
Immunity
1 Citation (Scopus)

Erratum: Immune clearance of highly pathogenic SIV infection (Nature (2013) 502 (100-104) DOI:10.1038/nature12519))

Hansen, S., Piatak, M., Ventura, A. B., Hughes, C. M., Gilbride, R. M., Ford, J. C., Oswald, K., Shoemaker, R., Li, Y., Lewis, M. S., Gilliam, A. N., Xu, G., Whizin, N., Burwitz, B., Planer, S. L., Turner, J. M., Legasse, A. W., Axthelm, M., Nelson, J., Frueh, K. & 6 others, Sacha, J., Estes, J., Keele, B. F., Edlefsen, P. T., Lifson, J. D. & Picker, L., Oct 30 2014, In : Nature. 514, 7524, p. 654 1 p.

Research output: Contribution to journalArticle

Infection
18 Citations (Scopus)

Heterogeneity of CD4+ and CD8+ T-cell responses to cytomegalovirus in HIV-infected and HIV-uninfected men who have sex with men

Li, H., Margolick, J. B., Bream, J. H., Nilles, T. L., Langan, S., Bui, H. T., Sylwester, A., Picker, L. & Leng, S. X., Aug 1 2014, In : Journal of Infectious Diseases. 210, 3, p. 400-404 5 p.

Research output: Contribution to journalArticle

Cytomegalovirus
HIV
T-Lymphocytes
Antigens
Open Reading Frames
22 Citations (Scopus)

Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events

Del Prete, G. Q., Park, H., Fennessey, C. M., Reid, C., Lipkey, L., Newman, L., Oswald, K., Kahl, C., Piatak, M., Quiñones, O. A., Gregory Alvord, W., Smedley, J., Estes, J., Lifson, J. D., Picker, L. & Keele, B. F., 2014, In : Journal of Virology. 88, 14, p. 8077-8090 14 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
swarms
Sequence Analysis
sequence analysis
51 Citations (Scopus)

Novel vaccine vectors for HIV.1

Barouch, D. H. & Picker, L., Jan 1 2014, In : Nature Reviews Microbiology. 12, 11, p. 765-771 7 p.

Research output: Contribution to journalArticle

Vaccines
Cytomegalovirus Vaccines
Adenovirus Vaccines
Simian Immunodeficiency Virus
Macaca mulatta
2013
134 Citations (Scopus)

CD4+ T-Cell Depletion In Hiv Infection: Mechanisms Of Immunological Failure

Okoye, A. & Picker, L., Jul 2013, In : Immunological Reviews. 254, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Infection
Opportunistic Infections
Regeneration
Population
248 Citations (Scopus)

Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms

Hansen, S., Sacha, J., Hughes, C. M., Ford, J. C., Burwitz, B., Scholz, I., Gilbride, R. M., Lewis, M. S., Gilliam, A. N., Ventura, A. B., Malouli, D., Xu, G., Richards, R., Whizin, N., Reed, J. S., Hammond, K. B., Fischer, M., Turner, J. M., Legasse, A. W., Axthelm, M. & 5 others, Edlefsen, P. T., Nelson, J., Lifson, J. D., Frueh, K. & Picker, L., 2013, In : Science. 340, 6135, 1237874.

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Cytomegalovirus
Simian Immunodeficiency Virus
T-Lymphocytes
Epitopes
39 Citations (Scopus)

Development of replication-competent viral vectors for HIV vaccine delivery

Parks, C. L., Picker, L. & King, C. R., Sep 2013, In : Current Opinion in HIV and AIDS. 8, 5, p. 402-411 10 p.

Research output: Contribution to journalArticle

AIDS Vaccines
Macaca
Clinical Trials
Vaccines
Viruses
5 Citations (Scopus)

HIV: Antibodies advance the search for a cure

Picker, L. & Deeks, S. G., 2013, In : Nature. 503, 7475, p. 207-208 2 p.

Research output: Contribution to journalArticle

Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
HIV Antibodies
Viremia
Neutralizing Antibodies
328 Citations (Scopus)

Immune clearance of highly pathogenic SIV infection

Hansen, S., Jr, M. P., Ventura, A. B., Hughes, C. M., Gilbride, R. M., Ford, J. C., Oswald, K., Shoemaker, R., Li, Y., Lewis, M. S., Gilliam, A. N., Xu, G., Whizin, N., Burwitz, B., Planer, S. L., Turner, J. M., Legasse, A. W., Axthelm, M., Nelson, J., Frueh, K. & 6 others, Sacha, J., Estes, J., Keele, B. F., Edlefsen, P. T., Lifson, J. D. & Picker, L., 2013, In : Nature. 502, 7469, p. 100-104 5 p.

Research output: Contribution to journalArticle

HIV
Infection
Macaca mulatta
Cytomegalovirus
T-Lymphocytes
36 Citations (Scopus)

Polyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV gag protein-induced t cell responses in nonhuman primates

Park, H., Adamson, L., Ha, T., Mullen, K., Hagen, S. I., Nogueron, A., Sylwester, A., Axthelm, M., Legasse, A., Piatak, M., Lifson, J. D., McElrath, J. M., Picker, L. & Seder, R. A., Apr 15 2013, In : Journal of Immunology. 190, 8, p. 4103-4115 13 p.

Research output: Contribution to journalArticle

gag Gene Products
Poly I-C
Primates
T-Lymphocytes
Macaca mulatta
5 Citations (Scopus)

Roadblocks to translational challenges on viral pathogenesis

Deeks, S., Drosten, C., Picker, L., Subbarao, K. & Suzich, J., Jan 2013, In : Nature Medicine. 19, 1, p. 30-34 5 p.

Research output: Contribution to journalArticle

Virus Diseases
Research
Medicine
Research Personnel
Therapeutics
2012
33 Citations (Scopus)

Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques

Klatt, N. R., Canary, L. A., Vanderford, T. H., Vinton, C. L., Engram, J. C., Dunham, R. M., Cronise, H. E., Swerczek, J. M., Lafont, B. A. P., Picker, L., Silvestri, G. & Brenchley, J. M., Jan 2012, In : Journal of Virology. 86, 2, p. 1203-1213 11 p.

Research output: Contribution to journalArticle

Macaca nemestrina
Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virus Diseases
Macaca
3 Citations (Scopus)

Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control

Sugimoto, C., Nakamura, S., Hagen, S. I., Tsunetsugu-Yokota, Y., Villinger, F., Ansari, A. A., Suzuki, Y., Yamamoto, N., Nagai, Y., Picker, L. & Mori, K., Sep 2012, In : Journal of Virology. 86, 17, p. 9323-9336 14 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
immunosuppression
glycosylation
Glycosylation
82 Citations (Scopus)

Hidden memories: Frontline memory T cells and early pathogen interception

Masopust, D. & Picker, L., Jun 15 2012, In : Journal of Immunology. 188, 12, p. 5811-5817 7 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Aptitude
Vaccines
Immunologic Memory
Lymphoid Tissue
99 Citations (Scopus)

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

Fukazawa, Y., Park, H., Cameron, M. J., Lefebvre, F., Lum, R., Coombes, N., Mahyari, E., Hagen, S. I., Bae, J. Y., Reyes, M. D., Swanson, T., Legasse, A. W., Sylwester, A., Hansen, S., Smith, A. T., Stafova, P., Shoemaker, R., Li, Y., Oswald, K., Axthelm, M. & 8 others, McDermott, A., Ferrari, G., Montefiori, D. C., Edlefsen, P. T., Piatak, M., Lifson, J. D., Sékaly, R. P. & Picker, L., Nov 2012, In : Nature Medicine. 18, 11, p. 1673-1681 9 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
T-cells
Viruses
Vaccines
Lymph Nodes
18 Citations (Scopus)

Naive T cells are dispensable for memory CD4 + T cell homeostasis in progressive simian immunodeficiency virus infection

Okoye, A., Rohankhedkar, M., Abana, C., Pattenn, A., Reyes, M., Pexton, C., Lum, R., Sylwester, A., Planer, S. L., Legasse, A., Park, B., Piatak, M., Lifson, J. D., Axthelm, M. & Picker, L., Apr 9 2012, In : Journal of Experimental Medicine. 209, 4, p. 641-651 11 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Homeostasis
T-Lymphocytes
Disease Progression
97 Citations (Scopus)

New paradigms for HIV/AIDS vaccine development

Picker, L., Hansen, S. & Lifson, J. D., 2012, In : Annual Review of Medicine. 63, p. 95-111 17 p.

Research output: Contribution to journalArticle

AIDS Vaccines
Viruses
Vaccines
Immune system
Antiviral Agents
2011
44 Citations (Scopus)

Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques

Čičin-Šain, L., Sylwester, A., Hagen, S. I., Siess, D. C., Currier, N., Legasse, A. W., Fischer, M. B., Koudelka, C. W., Axthelm, M., Nikolich-Žugich, J. & Picker, L., Aug 15 2011, In : Journal of Immunology. 187, 4, p. 1722-1732 11 p.

Research output: Contribution to journalArticle

Macaca mulatta
Cytomegalovirus
Immunity
T-Lymphocytes
Population Control
50 Citations (Scopus)

HIV-1 vaccines and adaptive trial designs

Corey, L., Nabel, G. J., Dieffenbach, C., Gilbert, P., Haynes, B. F., Johnston, M., Kublin, J., Clifford Lane, H., Pantaleo, G., Picker, L. & Fauci, A. S., Apr 20 2011, In : Science Translational Medicine. 3, 79, 79ps13.

Research output: Contribution to journalArticle

HIV-1
Vaccines
HIV
Lentivirus Infections
Primate Lentiviruses
14 Citations (Scopus)

Naïve and memory B cells in the rhesus macaque can be differentiated by surface expression of CD27 and have differential responses to CD40 ligation

Kuhrt, D., Faith, S., Hattemer, A., Leone, A., Sodora, D., Picker, L., Borghesi, L. & Cole, K. S., Jan 5 2011, In : Journal of Immunological Methods. 363, 2, p. 166-176 11 p.

Research output: Contribution to journalArticle

Macaca mulatta
Ligation
B-Lymphocytes
Population
Point Mutation