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1976 …2020

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2020

In vivo validation of the viral barcoding of simian immunodeficiency virus SIVmac239 and the development of new barcoded SIV and subtype B and C simian-human immunodeficiency viruses

Khanal, S., Fennessey, C. M., O'Brien, S. P., Thorpe, A., Reid, C., Immonen, T. T., Smith, R., Bess, J. W., Swanstrom, A. E., Del Prete, G. Q., Davenport, M. P., Okoye, A. A., Picker, L. J., Lifson, J. D. & Keele, B. F., Jan 1 2020, In : Journal of virology. 94, 1, e01420-19.

Research output: Contribution to journalArticle

1 Scopus citations

MHC-E-Restricted CD8+ T cells target Hepatitis B virus-infected human hepatocytes

Burwitz, B., Hashiguchi, P. K., Mansouri, M., Meyer, C., Gilbride, R. M., Biswas, S., Womack, J. L., Reed, J. S., Wu, H. L., Axthelm, M., Hansen, S. G., Picker, L. J., Frueh, K. & Sacha, J., Apr 15 2020, In : Journal of Immunology. 204, 8, p. 2169-2176 8 p.

Research output: Contribution to journalArticle

2019

Acute infection and subsequent subclinical reactivation of herpes simplex virus 2 after vaginal inoculation of rhesus macaques

Lo, M., Zhu, J., Hansen, S. G., Carroll, T., Zuend, C. F., Nöel-Romas, L., Ma, Z. M., Fritts, L., Huang, M. L., Sun, S., Huang, Y., Koelle, D. M., Picker, L. J., Burgener, A., Corey, L. & Miller, C. J., Jan 1 2019, In : Journal of virology. 93, 2, e01574-18.

Research output: Contribution to journalArticle

1 Scopus citations

Characterization of a live-attenuated HCMV-based vaccine platform

Caposio, P., van den Worm, S., Crawford, L., Perez, W., Kreklywich, C., Gilbride, R. M., Hughes, C. M., Ventura, A. B., Ratts, R., Marshall, E. E., Malouli, D., Axthelm, M. K., Streblow, D., Nelson, J. A., Picker, L. J., Hansen, S. G. & Früh, K., Dec 1 2019, In : Scientific Reports. 9, 1, 19236.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Cytomegalovirus vectors expressing Plasmodium knowlesi antigens induce immune responses that delay parasitemia upon sporozoite challenge

Hansen, S., Womack, J., Scholz, I., Renner, A., Edgel, K. A., Xu, G., Ford, J. C., Grey, M., St. Laurent, B., Turner, J. M., Planer, S., Legasse, A. W., Richie, T. L., Aguiar, J. C., Axthelm, M., Villasante, E. D., Weiss, W., Edlefsen, P. T., Picker, L. & Frueh, K., Jan 1 2019, In : PLoS One. 14, 1, e0210252.

Research output: Contribution to journalArticle

10 Scopus citations

Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Marshall, E., Malouli, D., Hansen, S., Gilbride, R. M., Hughes, C. M., Ventura, A. B., Ainslie, E., Selseth, A. N., Ford, J. C., Burke, D., Kreklywich, C. N., Womack, J., Legasse, A. W., Axthelm, M., Kahl, C., Streblow, D., Edlefsen, P. T., Picker, L. & Frueh, K., Jul 17 2019, In : Science Translational Medicine. 11, 501, eaaw2603.

Research output: Contribution to journalArticle

6 Scopus citations

Identification and functional characterization of a novel Fc gamma-binding glycoprotein in rhesus cytomegalovirus

Kolb, P., Sijmons, S., McArdle, M. R., Taher, H., Womack, J., Hughes, C., Ventura, A., Jarvis, M. A., Stahl-Hennig, C., Hansen, S., Picker, L., Malouli, D., Hengel, H. & Frueh, K., Feb 1 2019, In : Journal of virology. 93, 4, e0207718.

Research output: Contribution to journalArticle

2 Scopus citations

Immunometabolic signatures predict risk of progression to active tuberculosis and disease outcome

GC6-74 Consortium, Jan 1 2019, In : Frontiers in immunology. 10, MAR, 527.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

Thompson, H. L., Smithey, M. J., Uhrlaub, J. L., Jeftić, I., Jergović, M., White, S. E., Currier, N., Lang, A. M., Okoye, A., Park, B., Picker, L. J., Surh, C. D. & Nikolich-Žugich, J., Feb 1 2019, In : Aging Cell. 18, 1, e12865.

Research output: Contribution to journalArticle

9 Scopus citations

Role of IL-15 signaling in the pathogenesis of simian immunodeficiency virus infection in rhesus macaques

Okoye, A. A., DeGottardi, M. Q., Fukazawa, Y., Vaidya, M., Abana, C. O., Konfe, A. L., Fachko, D. N., Duell, D. M., Li, H., Lum, R., Gao, L., Park, B. S., Skalsky, R. L., Lewis, A. D., Axthelm, M. K., Lifson, J. D., Wong, S. W. & Picker, L. J., Dec 1 2019, In : Journal of Immunology. 203, 11, p. 2928-2943 16 p.

Research output: Contribution to journalArticle

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

Bender, A. M., Simonetti, F. R., Kumar, M. R., Fray, E. J., Bruner, K. M., Timmons, A. E., Tai, K. Y., Jenike, K. M., Antar, A. A. R., Liu, P. T., Ho, Y. C., Raugi, D. N., Seydi, M., Gottlieb, G. S., Okoye, A., Del Prete, G. Q., Picker, L., Mankowski, J. L., Lifson, J. D., Siliciano, J. D. & 4 others, Laird, G. M., Barouch, D. H., Clements, J. E. & Siliciano, R. F., Jul 10 2019, In : Cell Host and Microbe. 26, 1, p. 73-85.e4

Research output: Contribution to journalArticle

7 Scopus citations

Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+ T Cells in Nonhuman Primates

Abdulhaqq, S. A., Wu, H., Schell, J. B., Hammond, K. B., Reed, J. S., Legasse, A. W., Axthelm, M. K., Park, B. S., Asokan, A., Früh, K., Hansen, S. G., Picker, L. J. & Sacha, J. B., Oct 1 2019, In : Journal of virology. 93, 19

Research output: Contribution to journalArticle

1 Scopus citations
2018

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Okoye, A. A., Hansen, S. G., Vaidya, M., Fukazawa, Y., Park, H., Duell, D. M., Lum, R., Hughes, C. M., Ventura, A. B., Ainslie, E., Ford, J. C., Morrow, D., Gilbride, R. M., Legasse, A. W., Hesselgesser, J., Geleziunas, R., Li, Y., Oswald, K., Shoemaker, R., Fast, R. & 6 others, Bosche, W. J., Borate, B. R., Edlefsen, P. T., Axthelm, M. K., Picker, L. J. & Lifson, J. D., Sep 1 2018, In : Nature medicine. 24, 9, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Walters, L. C., Harlos, K., Brackenridge, S., Rozbesky, D., Barrett, J. R., Jain, V., Walter, T. S., O’Callaghan, C. A., Borrow, P., Toebes, M., Hansen, S., Sacha, J., Abdulhaqq, S., Greene, J. M., Frueh, K., Marshall, E., Picker, L., Jones, E. Y., McMichael, A. J. & Gillespie, G. M., Dec 1 2018, In : Nature Communications. 9, 1, 3137.

Research output: Contribution to journalArticle

15 Scopus citations

Potent immune modulation by medi6383, an engineered human ox40 ligand igg4p fc fusion protein

Oberst, M. D., Auge, C., Morris, C., Kentner, S., Mulgrew, K., McGlinchey, K., Hair, J., Hanabuchi, S., Du, Q., Damschroder, M., Feng, H., Eck, S., Buss, N., de Haan, L., Pierce, A. J., Park, H., Sylwester, A., Axthelm, M., Picker, L., Morris, N. P. & 2 others, Weinberg, A. & Hammond, S. A., May 1 2018, In : Molecular Cancer Therapeutics. 17, 5, p. 1024-1038 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

Hansen, S. G., Zak, D. E., Xu, G., Ford, J. C., Marshall, E. E., Malouli, D., Gilbride, R. M., Hughes, C. M., Ventura, A. B., Ainslie, E., Randall, K. T., Selseth, A. N., Rundstrom, P., Herlache, L., Lewis, M. S., Park, H., Planer, S. L., Turner, J. M., Fischer, M., Armstrong, C. & 20 others, Zweig, R. C., Valvo, J., Braun, J. M., Shankar, S., Lu, L., Sylwester, A. W., Legasse, A. W., Messerle, M., Jarvis, M. A., Amon, L. M., Aderem, A., Alter, G., Laddy, D. J., Stone, M., Bonavia, A., Evans, T. G., Axthelm, M. K., Früh, K., Edlefsen, P. T. & Picker, L. J., Feb 1 2018, In : Nature medicine. 24, 2, p. 130-143 14 p.

Research output: Contribution to journalArticle

72 Scopus citations

The Role of MHC-E in T Cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques

Wu, H. L., Wiseman, R. W., Hughes, C. M., Webb, G. M., Abdulhaqq, S. A., Bimber, B. N., Hammond, K. B., Reed, J. S., Gao, L., Burwitz, B. J., Greene, J. M., Ferrer, F., Legasse, A. W., Axthelm, M. K., Park, B. S., Brackenridge, S., Maness, N. J., McMichael, A. J., Picker, L. J., O'Connor, D. H. & 2 others, Hansen, S. G. & Sacha, J. B., Jan 1 2018, In : Journal of Immunology. 200, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
2017

Human cytomegalovirus induces cellular and humoral virus-specific immune responses in humanized BLT mice

Crawford, L. B., Tempel, R., Streblow, D., Kreklywich, C., Smith, P., Picker, L., Nelson, J. & Caposio, P., Dec 1 2017, In : Scientific Reports. 7, 1, 937.

Research output: Contribution to journalArticle

16 Scopus citations

MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates

Greene, J. M., Dash, P., Roy, S., McMurtrey, C., Awad, W., Reed, J. S., Hammond, K. B., Abdulhaqq, S., Wu, H. L., Burwitz, B., Roth, B. F., Morrow, D. W., Ford, J. C., Xu, G., Bae, J. Y., Crank, H., Legasse, A. W., Dang, T. H., Greenaway, H. Y., Kurniawan, M. & 14 others, Gold, M., Harriff, M., Lewinsohn, D., Park, B., Axthelm, M., Stanton, J., Hansen, S., Picker, L., Venturi, V., Hildebrand, W., Thomas, P. G., Lewinsohn, D., Adams, E. J. & Sacha, J., May 1 2017, In : Mucosal Immunology. 10, 3, p. 802-813 12 p.

Research output: Contribution to journalArticle

37 Scopus citations
2016

A new perspective of the structural complexity of HCMV-specific T-cell responses

Sylwester, A., Nambiar, K. Z., Caserta, S., Klenerman, P., Picker, L. J. & Kern, F., Sep 1 2016, In : Mechanisms of Ageing and Development. 158, p. 14-22 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion

Ranasinghe, S., Lamothe, P. A., Soghoian, D. Z., Kazer, S. W., Cole, M. B., Shalek, A. K., Yosef, N., Jones, R. B., Donaghey, F., Nwonu, C., Jani, P., Clayton, G. M., Crawford, F., White, J., Montoya, A., Power, K., Allen, T. M., Streeck, H., Kaufmann, D. E., Picker, L. & 2 others, Kappler, J. W. & Walker, B. D., Oct 18 2016, In : Immunity. 45, 4, p. 917-930 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

Hansen, S., Wu, H. L., Burwitz, B., Hughes, C. M., Hammond, K. B., Ventura, A. B., Reed, J. S., Gilbride, R. M., Ainslie, E., Morrow, D. W., Ford, J. C., Selseth, A. N., Pathak, R., Malouli, D., Legasse, A. W., Axthelm, M., Nelson, J., Gillespie, G. M., Walters, L. C., Brackenridge, S. & 8 others, Sharpe, H. R., López, C. A., Frueh, K., Korber, B. T., McMichael, A. J., Gnanakaran, S., Sacha, J. & Picker, L., Feb 12 2016, In : Science. 351, 6274, p. 714-720 7 p.

Research output: Contribution to journalArticle

141 Scopus citations

Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques

Burwitz, B., Malouli, D., Bimber, B. N., Reed, J. S., Ventura, A. B., Hancock, M., Uebelhoer, L. S., Bhusari, A., Hammond, K. B., Espinosa Trethewy, R. G., Klug, A., Legasse, A. W., Axthelm, M., Nelson, J., Park, B., Streblow, D., Hansen, S., Picker, L., Frueh, K. & Sacha, J., Nov 1 2016, In : PLoS Pathogens. 12, 11, e1006014.

Research output: Contribution to journalArticle

16 Scopus citations

Effect of anti-IL-15 administration on T Cell and NK cell homeostasis in rhesus macaques

Degottardi, M. Q., Okoye, A., Vaidya, M., Talla, A., Konfe, A. L., Reyes, M. D., Clock, J. A., Duell, D. M., Legasse, A. W., Sabnis, A., Park, B., Axthelm, M., Estes, J., Reiman, K. A., Sekaly, R. P. & Picker, L., Aug 15 2016, In : Journal of Immunology. 197, 4, p. 1183-1198 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

Epigraph: A vaccine design tool applied to an HIV therapeutic vaccine and a pan-filovirus vaccine

Theiler, J., Yoon, H., Yusim, K., Picker, L., Frueh, K. & Korber, B., Oct 5 2016, In : Scientific Reports. 6, 33987.

Research output: Contribution to journalArticle

13 Scopus citations

In situ staining and laser capture microdissection of lymph node residing SIV Gag-specific CD8+ T cells - A tool to interrogate a functional immune response ex vivo

Tjernlund, A., Burgener, A., Lindvall, J. M., Peng, T., Zhu, J., Öhrmalm, L., Picker, L., Broliden, K., McElrath, M. J. & Corey, L., Mar 1 2016, In : PLoS One. 11, 3, e0149907.

Research output: Contribution to journalArticle

3 Scopus citations

Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus

Sturgill, E. R., Malouli, D., Hansen, S., Burwitz, B., Seo, S., Schneider, C. L., Womack, J. L., Verweij, M., Ventura, A. B., Bhusari, A., Jeffries, K. M., Legasse, A. W., Axthelm, M., Hudson, A. W., Sacha, J., Picker, L. & Frueh, K., Aug 1 2016, In : PLoS Pathogens. 12, 8, e1005868.

Research output: Contribution to journalArticle

17 Scopus citations
2015

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

Fukazawa, Y., Lum, R., Okoye, A. A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., Morcock, D., Swanson, T., Legasse, A. W., Axthelm, M. K., Hesselgesser, J., Geleziunas, R., Hirsch, V. M., Edlefsen, P. T., Piatak, M., Estes, J. D. & 2 others, Lifson, J. D. & Picker, L. J., Feb 2015, In : Nature medicine. 21, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

269 Scopus citations

Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques

Okoye, A. A., Rohankhedkar, M., Konfe, A. L., Abana, C. O., Reyes, M. D., Clock, J. A., Duell, D. M., Sylwester, A. W., Sammader, P., Legasse, A. W., Park, B. S., Axthelm, M. K., Nikolich-Žugich, J. & Picker, L. J., Nov 2015, In : Journal of Immunology. 195, 9, p. 4292-4305 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance

Yang, O. O., Ali, A., Kasahara, N., Faure-Kumar, E., Bae, J. Y., Picker, L. J. & Park, H., Jan 1 2015, In : Journal of virology. 89, 2, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Vaccine-induced linear epitope-specific antibodies to simian immunodeficiency virus SIVmac239 envelope are distinct from those induced to the human immunodeficiency virus type 1 envelope in nonhuman primates

Shen, X., Duffy, R., Howington, R., Cope, A., Sadagopal, S., Park, H., Pal, R., Kwa, S., Ding, S., Yang, O. O., Fouda, G. G., Grand, R. L., Bolton, D., Esteban, M., Phogat, S., Roederer, M., Amara, R. R., Picker, L. J., Seder, R. A., Juliana McElrath, M. & 10 others, Barnett, S., Permar, S. R., Shattock, R., DeVico, A. L., Felber, B. K., Pavlakis, G. N., Pantaleo, G., Korber, B. T., Montefiori, D. C. & Tomaras, G. D., Jan 1 2015, In : Journal of virology. 89, 16, p. 8643-8650 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2014

Cytomegalovirus pp65 limits dissemination but is dispensable for persistence

Malouli, D., Hansen, S. G., Nakayasu, E. S., Marshall, E. E., Hughes, C. M., Ventura, A. B., Gilbride, R. M., Lewis, M. S., Xu, G., Kreklywich, C., Whizin, N., Fischer, M., Legasse, A. W., Viswanathan, K., Siess, D., Camp, D. G., Axthelm, M. K., Kahl, C., DeFilippis, V. R., Smith, R. D. & 3 others, Streblow, D. N., Picker, L. J. & Früh, K., 2014, In : Journal of Clinical Investigation. 124, 5, p. 1928-1944 17 p.

Research output: Contribution to journalArticle

19 Scopus citations

Heterogeneity of CD4+ and CD8+ T-cell responses to cytomegalovirus in HIV-infected and HIV-uninfected men who have sex with men

Li, H., Margolick, J. B., Bream, J. H., Nilles, T. L., Langan, S., Bui, H. T., Sylwester, A. W., Picker, L. J. & Leng, S. X., Aug 1 2014, In : Journal of Infectious Diseases. 210, 3, p. 400-404 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events

Del Prete, G. Q., Park, H., Fennessey, C. M., Reid, C., Lipkey, L., Newman, L., Oswald, K., Kahl, C., Piatak, M., Quiñones, O. A., Gregory Alvord, W., Smedley, J., Estes, J. D., Lifson, J. D., Picker, L. J. & Keele, B. F., Jul 2014, In : Journal of virology. 88, 14, p. 8077-8090 14 p.

Research output: Contribution to journalArticle

25 Scopus citations
2013

CD4+ T-Cell Depletion In Hiv Infection: Mechanisms Of Immunological Failure

Okoye, A. A. & Picker, L. J., Jul 1 2013, In : Immunological reviews. 254, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

158 Scopus citations

Immune clearance of highly pathogenic SIV infection

Hansen, S. G., Jr, M. P., Ventura, A. B., Hughes, C. M., Gilbride, R. M., Ford, J. C., Oswald, K., Shoemaker, R., Li, Y., Lewis, M. S., Gilliam, A. N., Xu, G., Whizin, N., Burwitz, B. J., Planer, S. L., Turner, J. M., Legasse, A. W., Axthelm, M. K., Nelson, J. A., Früh, K. & 6 others, Sacha, J. B., Estes, J. D., Keele, B. F., Edlefsen, P. T., Lifson, J. D. & Picker, L. J., Jan 1 2013, In : Nature. 502, 7469, p. 100-104 5 p.

Research output: Contribution to journalArticle

360 Scopus citations

Polyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV gag protein-induced t cell responses in nonhuman primates

Park, H., Adamson, L., Ha, T., Mullen, K., Hagen, S. I., Nogueron, A., Sylwester, A. W., Axthelm, M. K., Legasse, A., Piatak, M., Lifson, J. D., McElrath, J. M., Picker, L. J. & Seder, R. A., Apr 15 2013, In : Journal of Immunology. 190, 8, p. 4103-4115 13 p.

Research output: Contribution to journalArticle

39 Scopus citations
2012

Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques

Klatt, N. R., Canary, L. A., Vanderford, T. H., Vinton, C. L., Engram, J. C., Dunham, R. M., Cronise, H. E., Swerczek, J. M., Lafont, B. A. P., Picker, L. J., Silvestri, G. & Brenchley, J. M., Jan 1 2012, In : Journal of virology. 86, 2, p. 1203-1213 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control

Sugimoto, C., Nakamura, S., Hagen, S. I., Tsunetsugu-Yokota, Y., Villinger, F., Ansari, A. A., Suzuki, Y., Yamamoto, N., Nagai, Y., Picker, L. J. & Mori, K., Sep 1 2012, In : Journal of virology. 86, 17, p. 9323-9336 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

Fukazawa, Y., Park, H., Cameron, M. J., Lefebvre, F., Lum, R., Coombes, N., Mahyari, E., Hagen, S. I., Bae, J. Y., Reyes, M. D., Swanson, T., Legasse, A. W., Sylwester, A., Hansen, S. G., Smith, A. T., Stafova, P., Shoemaker, R., Li, Y., Oswald, K., Axthelm, M. K. & 8 others, McDermott, A., Ferrari, G., Montefiori, D. C., Edlefsen, P. T., Piatak, M., Lifson, J. D., Sékaly, R. P. & Picker, L. J., Nov 1 2012, In : Nature medicine. 18, 11, p. 1673-1681 9 p.

Research output: Contribution to journalArticle

104 Scopus citations

Naive T cells are dispensable for memory CD4 + T cell homeostasis in progressive simian immunodeficiency virus infection

Okoye, A. A., Rohankhedkar, M., Abana, C., Pattenn, A., Reyes, M., Pexton, C., Lum, R., Sylwester, A., Planer, S. L., Legasse, A., Park, B. S., Piatak, M., Lifson, J. D., Axthelm, M. K. & Picker, L. J., Apr 9 2012, In : Journal of Experimental Medicine. 209, 4, p. 641-651 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2011

Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques

Čičin-Šain, L., Sylwester, A. W., Hagen, S. I., Siess, D. C., Currier, N., Legasse, A. W., Fischer, M. B., Koudelka, C. W., Axthelm, M. K., Nikolich-Žugich, J. & Picker, L. J., Aug 15 2011, In : Journal of Immunology. 187, 4, p. 1722-1732 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Naïve and memory B cells in the rhesus macaque can be differentiated by surface expression of CD27 and have differential responses to CD40 ligation

Kuhrt, D., Faith, S., Hattemer, A., Leone, A., Sodora, D., Picker, L., Borghesi, L. & Cole, K. S., Jan 5 2011, In : Journal of Immunological Methods. 363, 2, p. 166-176 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

Hansen, S. G., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., Whizin, N., Oswald, K., Shoemaker, R., Swanson, T., Legasse, A. W., Chiuchiolo, M. J., Parks, C. L., Axthelm, M. K., Nelson, J. A., Jarvis, M. A., Piatak, M., Lifson, J. D. & Picker, L. J., May 26 2011, In : Nature. 473, 7348, p. 523-527 5 p.

Research output: Contribution to journalArticle

679 Scopus citations
2010

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

Hansen, S. G., Powers, C. J., Richards, R., Ventura, A. B., Ford, J. C., Siess, D., Axthelm, M. K., Nelson, J. A., Jarvis, M. A., Picker, L. J. & Früh, K., Apr 2 2010, In : Science. 328, 5974, p. 102-106 5 p.

Research output: Contribution to journalArticle

175 Scopus citations

Evidence of early B-cell dysregulation in simian immunodeficiency virus infection: Rapid depletion of naïve and memory B-cell subsets with delayed reconstitution of the naïve B-cell population

Kuhrt, D., Faith, S. A., Leone, A., Rohankedkar, M., Sodora, D. L., Picker, L. J. & Cole, K. S., Mar 1 2010, In : Journal of virology. 84, 5, p. 2466-2476 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses

Leone, A., Rohankhedkar, M., Okoye, A., Legasse, A., Axthelm, M. K., Villinger, F., Piatak, M., Lifson, J. D., Assouline, B., Morre, M., Picker, L. J. & Sodora, D. L., Aug 1 2010, In : Journal of Immunology. 185, 3, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques

Tjernlund, A., Zhu, J., Laing, K., Diem, K., McDonald, D., Vazquez, J., Cao, J., Ohlen, C., McElrath, M. J., Picker, L. J. & Corey, L., Feb 16 2010, In : Retrovirology. 7, 12.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M. K., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J. A., Jarvis, M. A. & Picker, L. J., Mar 1 2009, In : Nature medicine. 15, 3, p. 293-299 7 p.

Research output: Contribution to journalArticle

513 Scopus citations

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

Okoye, A., Park, H., Rohankhedkar, M., Coyne-Johnson, L., Lum, R., Walker, J. M., Planer, S. L., Legasse, A. W., Sylwester, A. W., Piatak, M., Lifson, J. D., Sodora, D. L., Villinger, F., Axthelm, M. K., Schmitz, J. E. & Picker, L. J., Jul 6 2009, In : Journal of Experimental Medicine. 206, 7, p. 1575-1588 14 p.

Research output: Contribution to journalArticle

56 Scopus citations