• 29756 Citations
  • 83 h-Index
1976 …2021

Research output per year

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Research Output

2002

An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive persons

Saavedra-Lozano, J., McCoig, C., Xu, J., Cao, Y., Keiser, P., Ghetie, V., Siliciano, R. F., Siliciano, J. D., Picker, L. J., Ramilo, O. & Vitetta, E. S., Feb 1 2002, In : Journal of Infectious Diseases. 185, 3, p. 306-314 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals

Kern, F., Bunde, T., Faulhaber, N., Kiecker, F., Khatamzas, E., Rudawski, I. M., Pruss, A., Gratama, J. W., Volkmer-Engert, R., Ewert, R., Reinke, P., Volk, H. D. & Picker, L. J., Jun 15 2002, In : Journal of Infectious Diseases. 185, 12, p. 1709-1716 8 p.

Research output: Contribution to journalArticle

206 Scopus citations

Development and homeostasis of T cell memory in rhesus macaque

Pitcher, C. J., Hagen, S. I., Walker, J. M., Lum, R., Mitchell, B. L., Maino, V. C., Axthelm, M. K. & Picker, L. J., Jan 1 2002, In : Journal of Immunology. 168, 1, p. 29-43 15 p.

Research output: Contribution to journalArticle

Open Access
388 Scopus citations

Differences between T cell epitopes recognized after immunization and after infection

Vogel, T. U., Horton, H., Fuller, D. H., Carter, D. K., Vielhuber, K., O'Connor, D. H., Shipley, T., Fuller, J., Sutter, G., Erfle, V., Wilson, N., Picker, L. J. & Watkins, D. I., Oct 15 2002, In : Journal of Immunology. 169, 8, p. 4511-4521 11 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Direct Ex vivo analysis of human CD4+ memory T cell activation requirements at the single clonotype level

Bitmansour, A. D., Douek, D. C., Maino, V. C. & Picker, L. J., Aug 1 2002, In : Journal of Immunology. 169, 3, p. 1207-1218 12 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations

Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection

Mothé, B. R., Horton, H., Carter, D. K., Allen, T. M., Liebl, M. E., Skinner, P., Vogel, T. U., Fuenger, S., Vielhuber, K., Rehrauer, W., Wilson, N., Franchini, G., Altman, J. D., Haase, A., Picker, L. J., Allison, D. B. & Watkins, D. I., Jan 15 2002, In : Journal of virology. 76, 2, p. 875-884 10 p.

Research output: Contribution to journalArticle

113 Scopus citations

Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239

Horton, H., Vogel, T. U., Carter, D. K., Vielhuber, K., Fuller, D. H., Shipley, T., Fuller, J. T., Kunstman, K. J., Sutter, G., Montefiori, D. C., Erfle, V., Desrosiers, R. C., Wilson, N., Picker, L. J., Wolinsky, S. M., Wang, C., Allison, D. B. & Watkins, D. I., Jul 1 2002, In : Journal of virology. 76, 14, p. 7187-7202 16 p.

Research output: Contribution to journalArticle

169 Scopus citations

Skewed maturation of virus-specific CTLs?

Gamadia, L. E., Ten Berge, I. J. M., Picker, L. J. & Van Lier, R. A. W., Mar 2002, In : Nature Immunology. 3, 3, 1 p.

Research output: Contribution to journalLetter

18 Scopus citations
2001

Analysis of total human immunodeficiency virus (HIV)-specific CD4+ and CD8+ T-cell responses: Relationship to viral load in untreated HIV infection

Betts, M. R., Ambrozak, D. R., Douek, D. C., Bonhoeffer, S., Brenchley, J. M., Casazza, J. P., Koup, R. A. & Picker, L. J., Dec 17 2001, In : Journal of virology. 75, 24, p. 11983-11991 9 p.

Research output: Contribution to journalArticle

596 Scopus citations

CD4+CD8dim T lymphocytes exhibit enhanced cytokine expression, proliferation and cytotoxic activity in response to HCMV and HIV-1 antigens

Suni, M. A., Ghanekar, S. A., Houck, D. W., Maecker, H. T., Wormsley, S. B., Picker, L. J., Moss, R. B. & Maino, V. C., Sep 6 2001, In : European Journal of Immunology. 31, 8, p. 2512-2520 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

Clonotypic structure of the human CD4+ memory T cell response to cytomegalovirus

Bitmansour, A. D., Waldrop, S. L., Pitcher, C. J., Khatamzas, E., Kern, F., Maino, V. C. & Picker, L. J., Aug 1 2001, In : Journal of Immunology. 167, 3, p. 1151-1163 13 p.

Research output: Contribution to journalArticle

Open Access
88 Scopus citations

Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy

Casazza, J. P., Betts, M. R., Picker, L. J. & Koup, R. A., Jul 7 2001, In : Journal of virology. 75, 14, p. 6508-6516 9 p.

Research output: Contribution to journalArticle

138 Scopus citations

Factors affecting the efficiency of CD8+ T cell cross-priming with exogenous antigens

Maecker, H. T., Ghanekar, S. A., Suni, M. A., He, X. S., Picker, L. J. & Maino, V. C., Jun 15 2001, In : Journal of Immunology. 166, 12, p. 7268-7275 8 p.

Research output: Contribution to journalArticle

Open Access
73 Scopus citations

Gamma interferon expression in CD8+ T cells is a marker for circulating cytotoxic T lymphocytes that recognize an HLA a2-restricted epitope of human cytomegalovirus phosphoprotein pp65

Ghanekar, S. A., Nomura, L. E., Suni, M. A., Picker, L. J., Maecker, H. T. & Maino, V. C., May 22 2001, In : Clinical and Diagnostic Laboratory Immunology. 8, 3, p. 628-631 4 p.

Research output: Contribution to journalArticle

58 Scopus citations

Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry

McKenna, R. W., Washington, L. B. T., Aquino, D. B., Picker, L. J. & Kroft, S. H., Oct 15 2001, In : Blood. 98, 8, p. 2498-2507 10 p.

Research output: Contribution to journalArticle

270 Scopus citations

Immunophenotypic analysis of peripheral T-cell neoplasms: A multiparameter flow cytometric approach

Jamal, S., Picker, L. J., Aquino, D. B., McKenna, R. W., Dawson, D. B. & Kroft, S. H., Oct 1 2001, In : American journal of clinical pathology. 116, 4, p. 512-526 15 p.

Research output: Contribution to journalArticle

88 Scopus citations

Impairment of Gag-specific CD8+ T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques

Hel, Z., Nacsa, J., Kelsall, B., Tsai, W. P., Letvin, N., Parks, R. W., Tryniszewska, E., Picker, L., Lewis, M. G., Edghill-Smith, Y., Moniuszko, M., Pal, R., Stevceva, L., Altman, J. D., Allen, T. M., Watkins, D., Torres, J. V., Berzofsky, J. A., Belyakov, I. M., Strober, W. & 1 others, Franchini, G., Nov 26 2001, In : Journal of virology. 75, 23, p. 11483-11495 13 p.

Research output: Contribution to journalArticle

58 Scopus citations

Recently identified measures of human thymic function

MacFarland, R. D., Picker, L. J., Koup, R. A. & Douek, D. C., Nov 1 2001, In : Clinical and Applied Immunology Reviews. 2, 1, p. 65-73 9 p.

Research output: Contribution to journalReview article

6 Scopus citations

The cutaneous response in humans to Treponema pallidum lipoprotein analogues involves cellular elements of both innate and adaptive immunity

Sellati, T. J., Waldrop, S. L., Salazar, J. C., Bergstresser, P. R., Picker, L. J. & Radolf, J. D., Mar 15 2001, In : Journal of Immunology. 166, 6, p. 4131-4140 10 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations
2000

De novo CD5+ diffuse large B-cell lymphomas: A heterogeneous group containing an unusual form of splenic lymphoma

Kroft, S. H., Howard, M. S., Picker, L. J., Ansari, M. Q., Aquino, D. B. & McKenna, R. W., Oct 1 2000, In : American journal of clinical pathology. 114, 4, p. 523-533 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Identification of a human recent thymic emigrant phenotype

McFarland, R. D., Douek, D. C., Koup, R. A. & Picker, L. J., Apr 11 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 8, p. 4215-4220 6 p.

Research output: Contribution to journalArticle

187 Scopus citations

Immunofluorescence analysis of T-cell responses in health and disease

Maecker, H. T., Maino, V. C. & Picker, L. J., Dec 1 2000, In : Journal of Clinical Immunology. 20, 6, p. 391-399 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Proving HIV-1 immunity: New tools offer new opportunities

Picker, L. J., Jan 1 2000, In : Journal of Clinical Investigation. 105, 10, p. 1333-1334 2 p.

Research output: Contribution to journalComment/debate

Open Access
3 Scopus citations

Putative immunodominant human immunodeficiency virus-specific CD8+ T-cell responses cannot be predicted by major histocompatibility complex class I haplotype

Betts, M. R., Casazza, J. P., Patterson, B. A., Waldrop, S., Trigona, W., Fu, T. M., Kern, F., Picker, L. J. & Koup, R. A., Jan 1 2000, In : Journal of virology. 74, 19, p. 9144-9151 8 p.

Research output: Contribution to journalArticle

137 Scopus citations

The CD4+ T cell response to HIV-1

Picker, L. J. & Maino, V. C., Aug 1 2000, In : Current opinion in immunology. 12, 4, p. 381-386 6 p.

Research output: Contribution to journalReview article

38 Scopus citations
1999

An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro

McCoig, C., Van Dyke, G., Chou, C. S., Picker, L. J., Ramilo, O. & Vitetta, E. S., Sep 28 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 20, p. 11482-11485 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

Distribution of human CMV-specific memory T cells among the CD8(pos.) subsets defined by CD57, CD27, and CD45 isoforms

Kern, F., Khatamzas, E., Surel, I., Frömmel, C., Reinke, P., Waldrop, S. L., Picker, L. J. & Volk, H. D., Jan 1 1999, In : European Journal of Immunology. 29, 9, p. 2908-2915 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

Evidence for superantigen involvement in skin homing of T cells in atopic dermatitis

Strickland, I., Hauk, P. J., Trumble, A. E., Picker, L. J. & Leung, D. Y. M., Jan 1 1999, In : Journal of Investigative Dermatology. 112, 2, p. 249-253 5 p.

Research output: Contribution to journalArticle

106 Scopus citations

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged vital suppression

Pitcher, C. J., Quittner, C., Peterson, D. M., Connors, M., Koup, R. A., Maino, V. C. & Picker, L. J., May 1999, In : Nature medicine. 5, 5, p. 518-525 8 p.

Research output: Contribution to journalArticle

656 Scopus citations
1998

Changes in thymic function with age and during the treatment of HIV infection

Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan, J. L., Jamieson, B. D., Zack, J. A., Picker, L. J. & Koup, R. A., Dec 17 1998, In : Nature. 396, 6712, p. 690-695 6 p.

Research output: Contribution to journalArticle

1472 Scopus citations

Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry

Suni, M. A., Picker, L. J. & Maino, V. C., Mar 1 1998, In : Journal of Immunological Methods. 212, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

243 Scopus citations

Identification of functional subsets by flow cytometry: Intracellular detection of cytokine expression

Maino, V. C. & Picker, L. J., Oct 15 1998, In : Communications in Clinical Cytometry. 34, 5, p. 207-215 9 p.

Research output: Contribution to journalReview article

190 Scopus citations

Normal human CD4+ memory T cells display broad heterogeneity in their activation threshold for cytokine synthesis

Waldrop, S. L., Davis, K. A., Maino, V. C. & Picker, L. J., Nov 15 1998, In : Journal of Immunology. 161, 10, p. 5284-5295 12 p.

Research output: Contribution to journalArticle

168 Scopus citations
1997

Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin

Olweus, J., BitMansour, A., Warnke, R., Thompson, P. A., Carballido, J., Picker, L. J. & Lund-Johansen, F., Nov 11 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 23, p. 12551-12556 6 p.

Research output: Contribution to journalArticle

373 Scopus citations

Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry. Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency

Waldrop, S. L., Pitcher, C. J., Peterson, D. M., Maino, V. C. & Picker, L. J., Apr 1 1997, In : Journal of Clinical Investigation. 99, 7, p. 1739-1750 12 p.

Research output: Contribution to journalArticle

Open Access
472 Scopus citations

Human recombinant interferon-β influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors

McRae, B. L., Picker, L. J. & Van Seventer, G. A., Oct 1 1997, In : European Journal of Immunology. 27, 10, p. 2650-2656 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Immune reconstitution with donor-derived memory/effector T cells after orthotopic liver transplantation

Collins, J., Sackler, M., Pitcher, C. J., Waldrop, S. L., Klintmalm, G. B., Jenkins, R. & Picker, L. J., Mar 13 1997, In : Experimental hematology. 25, 2, p. 147-159 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
67 Scopus citations

U.S.-Canadian consensus recommendations on the immunophenotypic analysis of hematologic neoplasia by flow cytometry: Data analysis and interpretation

Borowitz, M. J., Bray, R., Gascoyne, R., Melnick, S., Parker, J. W., Picker, L. & Stetler-Stevenson, M., Oct 15 1997, In : Communications in Clinical Cytometry. 30, 5, p. 236-244 9 p.

Research output: Contribution to journalArticle

109 Scopus citations
1996

CD44 and its ligand hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial cell primary adhesion pathway

DeGrendele, H. C., Estess, P., Picker, L. J. & Siegelman, M. H., Mar 1 1996, In : Journal of Experimental Medicine. 183, 3, p. 1119-1130 12 p.

Research output: Contribution to journalArticle

338 Scopus citations

Immunodetection of histone epitopes correlates with early stages of apoptosis in activated human peripheral T lymphocytes

Zunino, S. J., Singh, M. K., Bass, J. & Picker, L. J., Aug 1 1996, In : American Journal of Pathology. 149, 2, p. 653-663 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Lymphocyte homing and homeostasis

Butcher, E. C. & Picker, L. J., Apr 5 1996, In : Science. 272, 5258, p. 60-66 7 p.

Research output: Contribution to journalArticle

2400 Scopus citations

Neutrophil adhesion to 24-hour IL-1-stimulated endothelial cells under flow conditions

Jones, D. A., Smith, C. W., Picker, L. J. & McIntire, L. V., Jul 15 1996, In : Journal of Immunology. 157, 2, p. 858-863 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Primary body cavity-based AIDS-related lymphomas

Ansari, M. Q., Dawson, D. B., Nador, R., Rutherford, C., Schneider, N. R., Latimer, M. J., Picker, L., Knowles, D. M. & McKenna, R. W., Feb 1996, In : American journal of clinical pathology. 105, 2, p. 221-229 9 p.

Research output: Contribution to journalArticle

Open Access
221 Scopus citations
1995

Bacterial superantigens induce t cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production

Leung, D. Y. M., Gately, M., Trumble, A., Ferguson-Darnell, B., Schlievert, P. M. & Picker, L. J., Feb 1 1995, In : Journal of Experimental Medicine. 181, 2, p. 747-753 7 p.

Research output: Contribution to journalArticle

279 Scopus citations

Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen

Babi, L. F. S., Picker, L. J., Teresa Perez Soler, M., Drzimalla, K., Flohr, P., Blaser, K. & Hauser, C., May 1 1995, In : Journal of Experimental Medicine. 181, 5, p. 1935-1940 6 p.

Research output: Contribution to journalArticle

Open Access
244 Scopus citations

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

Picker, L. J., Singh, M. K., Zdraveski, Z., Treer, J. R., Waldrop, S. L., Bergstresser, P. R. & Maino, V. C., Jan 1 1995, In : Blood. 86, 4, p. 1408-1419 12 p.

Research output: Contribution to journalArticle

473 Scopus citations

Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation

Tortorella, C., Schulze-Koops, H., Thomas, R., Splawski, J. B., Davis, L. S., Picker, L. J. & Lipsky, P. E., Jan 1 1995, In : Journal of Immunology. 155, 1, p. 149-162 14 p.

Research output: Contribution to journalArticle

53 Scopus citations
117 Scopus citations