• 29996 Citations
  • 83 h-Index
1976 …2020

Research output per year

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Research Output

2013

Roadblocks to translational challenges on viral pathogenesis

Deeks, S., Drosten, C., Picker, L., Subbarao, K. & Suzich, J., Jan 1 2013, In : Nature medicine. 19, 1, p. 30-34 5 p.

Research output: Contribution to journalReview article

6 Scopus citations
2012

Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques

Klatt, N. R., Canary, L. A., Vanderford, T. H., Vinton, C. L., Engram, J. C., Dunham, R. M., Cronise, H. E., Swerczek, J. M., Lafont, B. A. P., Picker, L. J., Silvestri, G. & Brenchley, J. M., Jan 2012, In : Journal of virology. 86, 2, p. 1203-1213 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control

Sugimoto, C., Nakamura, S., Hagen, S. I., Tsunetsugu-Yokota, Y., Villinger, F., Ansari, A. A., Suzuki, Y., Yamamoto, N., Nagai, Y., Picker, L. J. & Mori, K., Sep 2012, In : Journal of virology. 86, 17, p. 9323-9336 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Hidden memories: Frontline memory T cells and early pathogen interception

Masopust, D. & Picker, L. J., Jun 15 2012, In : Journal of Immunology. 188, 12, p. 5811-5817 7 p.

Research output: Contribution to journalShort survey

84 Scopus citations

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

Fukazawa, Y., Park, H., Cameron, M. J., Lefebvre, F., Lum, R., Coombes, N., Mahyari, E., Hagen, S. I., Bae, J. Y., Reyes, M. D., Swanson, T., Legasse, A. W., Sylwester, A., Hansen, S. G., Smith, A. T., Stafova, P., Shoemaker, R., Li, Y., Oswald, K., Axthelm, M. K. & 8 others, McDermott, A., Ferrari, G., Montefiori, D. C., Edlefsen, P. T., Piatak, M., Lifson, J. D., Sékaly, R. P. & Picker, L. J., Nov 1 2012, In : Nature medicine. 18, 11, p. 1673-1681 9 p.

Research output: Contribution to journalArticle

104 Scopus citations

Naive T cells are dispensable for memory CD4 + T cell homeostasis in progressive simian immunodeficiency virus infection

Okoye, A. A., Rohankhedkar, M., Abana, C., Pattenn, A., Reyes, M., Pexton, C., Lum, R., Sylwester, A., Planer, S. L., Legasse, A., Park, B. S., Piatak, M., Lifson, J. D., Axthelm, M. K. & Picker, L. J., Apr 9 2012, In : Journal of Experimental Medicine. 209, 4, p. 641-651 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

New paradigms for HIV/AIDS vaccine development

Picker, L. J., Hansen, S. G. & Lifson, J. D., 2012, In : Annual review of medicine. 63, p. 95-111 17 p.

Research output: Contribution to journalReview article

100 Scopus citations
2011

Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques

Čičin-Šain, L., Sylwester, A. W., Hagen, S. I., Siess, D. C., Currier, N., Legasse, A. W., Fischer, M. B., Koudelka, C. W., Axthelm, M. K., Nikolich-Žugich, J. & Picker, L. J., Aug 15 2011, In : Journal of Immunology. 187, 4, p. 1722-1732 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

HIV-1 vaccines and adaptive trial designs

Corey, L., Nabel, G. J., Dieffenbach, C., Gilbert, P., Haynes, B. F., Johnston, M., Kublin, J., Clifford Lane, H., Pantaleo, G., Picker, L. J. & Fauci, A. S., Apr 20 2011, In : Science translational medicine. 3, 79, 79ps13.

Research output: Contribution to journalShort survey

52 Scopus citations

Naïve and memory B cells in the rhesus macaque can be differentiated by surface expression of CD27 and have differential responses to CD40 ligation

Kuhrt, D., Faith, S., Hattemer, A., Leone, A., Sodora, D., Picker, L., Borghesi, L. & Cole, K. S., Jan 5 2011, In : Journal of Immunological Methods. 363, 2, p. 166-176 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

Hansen, S. G., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., Whizin, N., Oswald, K., Shoemaker, R., Swanson, T., Legasse, A. W., Chiuchiolo, M. J., Parks, C. L., Axthelm, M. K., Nelson, J. A., Jarvis, M. A., Piatak, M., Lifson, J. D. & Picker, L. J., May 26 2011, In : Nature. 473, 7348, p. 523-527 5 p.

Research output: Contribution to journalArticle

681 Scopus citations
2010

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

Hansen, S. G., Powers, C. J., Richards, R., Ventura, A. B., Ford, J. C., Siess, D., Axthelm, M. K., Nelson, J. A., Jarvis, M. A., Picker, L. J. & Früh, K., Apr 2 2010, In : Science. 328, 5974, p. 102-106 5 p.

Research output: Contribution to journalArticle

175 Scopus citations

Evidence of early B-cell dysregulation in simian immunodeficiency virus infection: Rapid depletion of naïve and memory B-cell subsets with delayed reconstitution of the naïve B-cell population

Kuhrt, D., Faith, S. A., Leone, A., Rohankedkar, M., Sodora, D. L., Picker, L. J. & Cole, K. S., Mar 1 2010, In : Journal of virology. 84, 5, p. 2466-2476 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses

Leone, A., Rohankhedkar, M., Okoye, A., Legasse, A., Axthelm, M. K., Villinger, F., Piatak, M., Lifson, J. D., Assouline, B., Morre, M., Picker, L. J. & Sodora, D. L., Aug 1 2010, In : Journal of Immunology. 185, 3, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques

Tjernlund, A., Zhu, J., Laing, K., Diem, K., McDonald, D., Vazquez, J., Cao, J., Ohlen, C., McElrath, M. J., Picker, L. J. & Corey, L., Feb 16 2010, In : Retrovirology. 7, 12.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M. K., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J. A., Jarvis, M. A. & Picker, L. J., Mar 1 2009, In : Nature medicine. 15, 3, p. 293-299 7 p.

Research output: Contribution to journalArticle

514 Scopus citations

Erratum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge (Nature Medicine (2009) 15 (293-299))

Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M. K., Oswald, K., Trubey, C. M., Piatak, M., Lifson, J. D., Nelson, J. A., Jarvis, M. A. & Picker, L. J., Apr 1 2009, In : Nature medicine. 15, 4, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment

Leone, A., Picker, L. J. & Sodora, D. L., May 26 2009, In : Current HIV Research. 7, 1, p. 83-90 8 p.

Research output: Contribution to journalReview article

42 Scopus citations

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

Okoye, A., Park, H., Rohankhedkar, M., Coyne-Johnson, L., Lum, R., Walker, J. M., Planer, S. L., Legasse, A. W., Sylwester, A. W., Piatak, M., Lifson, J. D., Sodora, D. L., Villinger, F., Axthelm, M. K., Schmitz, J. E. & Picker, L. J., Jul 6 2009, In : Journal of Experimental Medicine. 206, 7, p. 1575-1588 14 p.

Research output: Contribution to journalArticle

56 Scopus citations

The transfer of adaptive immunity to CMVduring hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor

Scheinberg, P., Melenhorst, J. J., Brenchley, J. M., Hill, B. J., Hensel, N. F., Chattopadhyay, P. K., Roederer, M., Picker, L. J., Price, D. A., Barrett, A. J. & Douek, D. C., Dec 3 2009, In : Blood. 114, 24, p. 5071-5080 10 p.

Research output: Contribution to journalArticle

66 Scopus citations
2008

Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques

Price, D. A., Bitmansour, A. D., Edgar, J. B., Walker, J. M., Axthelm, M. K., Douek, D. C. & Picker, L. J., Jan 1 2008, In : Journal of Immunology. 180, 1, p. 269-280 12 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Pathogenic mechanisms in simian immunodeficiency virus infection

Grossman, Z. & Picker, L. J., May 1 2008, In : Current Opinion in HIV and AIDS. 3, 3, p. 380-386 7 p.

Research output: Contribution to journalReview article

17 Scopus citations

Replication in a superficial epithelial cell niche explains the lack of pathogenicity of primate foamy virus infections

Murray, S. M., Picker, L. J., Axthelm, M. K., Hudkins, K., Alpers, C. E. & Linial, M. L., Jun 2008, In : Journal of virology. 82, 12, p. 5981-5985 5 p.

Research output: Contribution to journalArticle

56 Scopus citations
2007

Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates

Čičin-Šain, L., Messaoudi, I., Park, B., Currier, N., Planer, S., Fischer, M., Tackitt, S., Nikolich-Žugich, D., Legasse, A., Axthelm, M. K., Picker, L. J., Mori, M. & Nikolich-Žugich, J., Dec 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 50, p. 19960-19965 6 p.

Research output: Contribution to journalArticle

96 Scopus citations

Erratum: Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection (Journal of Experimental Medicine (September 3, 2007) 204, 9, (2171-2185))

Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A. W., Piatak, M., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M. K., Grossman, Z. & Picker, L. J., Oct 1 2007, In : Journal of Experimental Medicine. 204, 10, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection

Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A. W., Piatak, M., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M. K., Grossman, Z. & Picker, L. J., Sep 3 2007, In : Journal of Experimental Medicine. 204, 9, p. 2171-2185 15 p.

Research output: Contribution to journalArticle

203 Scopus citations

Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys

Pereira, L. E., Villinger, F., Onlamoon, N., Bryan, P., Cardona, A., Pattanapanysat, K., Mori, K., Hagen, S., Picker, L. & Ansari, A. A., May 1 2007, In : Journal of virology. 81, 9, p. 4445-4456 12 p.

Research output: Contribution to journalArticle

58 Scopus citations
2006

Anti-OX40 (CD134) administration to nonhuman primates: Immunostimulatory effects and toxicokinetic study

Weinberg, A. D., Thalhofer, C., Morris, N., Walker, J. M., Seiss, D., Wong, S., Axthelm, M. K., Picker, L. J. & Urba, W. J., Nov 1 2006, In : Journal of Immunotherapy. 29, 6, p. 575-585 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates

Messaoudi, I., Warner, J., Fischer, M., Park, B., Hill, B., Mattison, J., Lane, M. A., Roth, G. S., Ingram, D. K., Picker, L. J., Douek, D. C., Mori, M. & Nikolich-Žugich, J., Dec 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 51, p. 19448-19453 6 p.

Research output: Contribution to journalArticle

161 Scopus citations

Expanded tissue targets for foamy virus replication with simian immunodeficiency virus-induced immunosuppression

Murray, S. M., Picker, L. J., Axthelm, M. K. & Linial, M. L., Jan 2006, In : Journal of virology. 80, 2, p. 663-670 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

IL-15 induces CD4+ effector memory T cell production and tissue emigration in nonhuman primates

Picker, L. J., Reed-Inderbitzin, E. F., Hagen, S. I., Edgar, J. B., Hansen, S. G., Legasse, A., Planer, S., Piatak, M., Lifson, J. D., Maino, V. C., Axthelm, M. K. & Villinger, F., Jun 1 2006, In : Journal of Clinical Investigation. 116, 6, p. 1514-1524 11 p.

Research output: Contribution to journalArticle

143 Scopus citations

Immunopathogenesis of acute AIDS virus infection

Picker, L. J., Aug 1 2006, In : Current opinion in immunology. 18, 4, p. 399-405 7 p.

Research output: Contribution to journalReview article

116 Scopus citations

Introduction

Veazey, R. S. & Picker, L. J., Aug 1 2006, In : Journal of medical primatology. 35, 4-5, 1 p.

Research output: Contribution to journalEditorial

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., Blazar, B. R., Rodriguez, B., Teixeira-Johnson, L., Landay, A., Martin, J. N., Hecht, F. M., Picker, L. J., Lederman, M. M., Deeks, S. G. & Douek, D. C., Dec 1 2006, In : Nature medicine. 12, 12, p. 1365-1371 7 p.

Research output: Contribution to journalArticle

2303 Scopus citations

Pathogenesis of HIV infection: What the virus spares is as important as what it destroys

Grossman, Z., Meier-Schellersheim, M., Paul, W. E. & Picker, L. J., Mar 1 2006, In : Nature medicine. 12, 3, p. 289-295 7 p.

Research output: Contribution to journalArticle

313 Scopus citations

Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection

Estes, J. D., Li, Q., Reynolds, M. R., Wietgrefe, S., Duan, L., Schacker, T., Picker, L. J., Watkins, D. I., Lifson, J. D., Reilly, C., Carlis, J. & Haase, A. T., Mar 1 2006, In : Journal of Infectious Diseases. 193, 5, p. 703-712 10 p.

Research output: Contribution to journalArticle

196 Scopus citations

Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239

Wilson, N. A., Reed, J., Napoe, G. S., Piaskowski, S., Szymanski, A., Furlott, J., Gonzalez, E. J., Yant, L. J., Maness, N. J., May, G. E., Soma, T., Reynolds, M. R., Rakasz, E., Rudersdorf, R., McDermott, A. B., O'Connor, D. H., Friedrich, T. C., Allison, D. B., Patki, A., Picker, L. J. & 13 others, Burton, D. R., Lin, J., Huang, L., Patel, D., Heindecker, G., Fan, J., Citron, M., Horton, M., Wang, F., Liang, X., Shiver, J. W., Casimiro, D. R. & Watkins, D. I., Jun 2006, In : Journal of virology. 80, 12, p. 5875-5885 11 p.

Research output: Contribution to journalArticle

189 Scopus citations
2005

Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects

Sylwester, A. W., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., Nelson, J. A. & Picker, L. J., Sep 5 2005, In : Journal of Experimental Medicine. 202, 5, p. 673-685 13 p.

Research output: Contribution to journalArticle

873 Scopus citations

Clinical, microbiological, and immunological characteristics in HIV-infected subjects at risk for disseminated Mycobacterium avium complex disease: An AACTG Study

MacGregor, R. R., Hafner, R., Wu, J. W., Murphy, R. L., Perlman, D. C., Bermudez, L. E., Inderlied, C. B., Picker, L. J., Wallis, R. S., Andersen, J. W., Mahon, L. F., Koletar, S. L. & Peterson, D. M., Aug 1 2005, In : AIDS Research and Human Retroviruses. 21, 8, p. 689-695 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Erratum: (The Journal of Experimental Medicine (September 5, 2005) 202:5 (673-685))

Sylwester, A. W., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., Nelson, J. A. & Picker, L. J., Nov 7 2005, In : Journal of Experimental Medicine. 202, 9, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

HIV pathogenesis: The first cut is the deepest

Picker, L. J. & Watkins, D. I., Dec 9 2005, In : Nature Immunology. 6, 5, p. 430-432 3 p.

Research output: Contribution to journalShort survey

77 Scopus citations
2004

An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory

Saavedra-Lozano, J., Cao, Y., Callison, J., Sarode, R., Sodora, D., Edgar, J., Hatfield, J., Picker, L., Peterson, D., Ramilo, O. & Vitetta, E. S., Feb 22 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 8, p. 2494-2499 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

A Sound Rationale Needed for Phase III HIV-1 Vaccine Trials

Burton, D. R., Desrosiers, R. C., Doms, R. W., Feinberg, M. B., Gallo, R. C., Hahn, B., Hoxie, J. A., Hunter, E., Korber, B., Landay, A., Lederman, M. M., Lieberman, J., McCune, J. M., Moore, J. P., Nathanson, N., Picker, L., Richman, D., Rinaldo, C., Stevenson, M., Watkins, D. I. & 2 others, Wolinsky, S. M. & Zack, J. A., Jan 16 2004, In : Science. 303, 5656, 1 p.

Research output: Contribution to journalShort survey

107 Scopus citations

Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection

Picker, L. J., Hagen, S. I., Lum, R., Reed-Inderbitzin, E. F., Daly, L. M., Sylwester, A. W., Walker, J. M., Siess, D. C., Piatak, M., Wang, C., Allison, D. B., Maino, V. C., Lifson, J. D., Kodama, T. & Axthelm, M. K., Nov 15 2004, In : Journal of Experimental Medicine. 200, 10, p. 1299-1314 16 p.

Research output: Contribution to journalArticle

254 Scopus citations

Multicolor flow cytometric analysis in SIV-infected rhesus macaque

Walker, J. M., Maecker, H. T., Maino, V. C. & Picker, L. J., Jan 1 2004, In : Methods in cell biology. 2004, 75, p. 535-557 23 p.

Research output: Contribution to journalArticle

28 Scopus citations

Support for the RV144 HIV vaccine trial [1] (multiple letters)

Belshe, R., Franchini, G., Girard, M. P., Gotch, F., Kaleebu, P., Marthas, M. L., McChesney, M. B., McCullough, R., Mhalu, F., Salmon-Ceron, D., Sekaly, R. P., Van Rompay, K., Verrier, B., Wahren, B., Weissenbacher, M., Baehr, M., Cappiello, D., Collins, C., Gold, D., Kaleebu, P. & 32 others, Menezes, A., Powell, M., Reinhard, R., Santiago, L., Snow, B., Thomas, J., Wakefield, S., Warren, M., Lee, E., Collins, H., Burton, D. R., Desrosiers, R. C., Doms, R. W., Feinberg, M. B., Hahn, B. H., Hoxie, J. A., Hunter, E., Korber, B. T. M., Landay, A. L., Lederman, M. M., Lieberman, J., McCune, J. M., Moore, J. P., Nathanson, N., Picker, L., Richman, D. D., Rinaldo, C. R., Stevenson, M., Watkins, D. I., Wolinsky, S. M., Zack, J. A. & Gallo, R. C., Jul 9 2004, In : Science. 305, 5681, p. 177-180 4 p.

Research output: Contribution to journalArticle

22 Scopus citations
2003

Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses

O'Connor, D. H., Mothe, B. R., Weinfurter, J. T., Fuenger, S., Rehrauer, W. M., Jing, P., Rudersdorf, R. R., Liebl, M. E., Krebs, K., Vasquez, J., Dodds, E., Loffredo, J., Martin, S., McDermott, A. B., Allen, T. M., Wang, C., Doxiadis, G. G., Montefiori, D. C., Hughes, A., Burton, D. R. & 5 others, Allison, D. B., Wolinsky, S. M., Bontrop, R., Picker, L. J. & Watkins, D. I., Aug 1 2003, In : Journal of virology. 77, 16, p. 9029-9040 12 p.

Research output: Contribution to journalArticle

131 Scopus citations

Mapping T cell epitopes by flow cytometry

Hoffmeister, B., Kiecker, F., Tesfa, L., Volk, H. D., Picker, L. J. & Kern, F., Mar 1 2003, In : Methods. 29, 3, p. 270-281 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

T cell dynamics in HIV-1 infection

Douek, D. C., Picker, L. J. & Koup, R. A., Oct 7 2003, In : Annual review of immunology. 21, p. 265-304 40 p.

Research output: Contribution to journalReview article

422 Scopus citations
2002

Analysis of the immune response and viral evolution during the acute phase of SIV infection

Horton, H., Vogel, T., O'Connor, D., Picker, L. & Watkins, D. I., May 6 2002, In : Vaccine. 20, 15, p. 1927-1932 6 p.

Research output: Contribution to journalArticle

10 Scopus citations