Knight Cancer Institute

Research Output

2020

AACR calls on congress to take immediate action against COVID-19 and protect patients with cancer during the pandemic

Mardis, E. R., Ribas, A., Hait, W. N., Jaffee, E. M., Foti, M., Abate-Shen, C., Albini, A., Bernards, R., Cruz-Correa, M. R., Flaherty, K. T., Greenberg, P. D., June, C. H., Knudsen, K. E., Liu, E. T., Mills, G. B., Piccart, M. J., Roussel, M. F., Siu, L. L., Swanton, C. & Tuveson, D. A., Jun 2020, In : Cancer discovery. 10, 6, p. 771-774 4 p.

Research output: Contribution to journalArticle

Open Access

A case study of 10 patients administered HBOC-201 in high doses over a prolonged period: outcomes during severe anemia when transfusion is not an option

Zumberg, M., Gorlin, J., Griffiths, E. A., Schwartz, G., Fletcher, B. S., Walsh, K., Dao, K. H., Vansandt, A., Lynn, M. & Shander, A., May 1 2020, In : Transfusion. 60, 5, p. 932-939 8 p.

Research output: Contribution to journalArticle

A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti-PD-1 antibody, in patients with advanced solid tumors

Naing, A., Gainor, J. F., Gelderblom, H., Forde, P. M., Butler, M. O., Lin, C. C., Sharma, S., Ochoa De Olza, M., Varga, A., Taylor, M., Schellens, J. H. M., Wu, H., Sun, H., Silva, A. P., Faris, J., Mataraza, J., Cameron, S. & Bauer, T. M., Mar 15 2020, In : Journal for immunotherapy of cancer. 8, 1, e000530.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4

Coleman, D. J., Sampson, D. A., Sehrawat, A., Kumaraswamy, A., Sun, D., Wang, Y., Schwartzman, J., Urrutia, J., Lee, A. R., Coleman, I. M., Nelson, P. S., Dong, X., Morrissey, C., Corey, E., Xia, Z., Yates, J. A. & Alumkal, J. J., Jun 2020, In : Neoplasia (United States). 22, 6, p. 253-262 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A multifunctional therapy approach for cancer: Targeting Raf1- Mediated inhibition of cell motility, growth, and interaction with the microenvironment

Zhang, L., Pattanayak, A., Li, W., Ko, H. K., Fowler, G., Gordon, R. & Bergan, R., Jan 1 2020, In : Molecular cancer therapeutics. 19, 1, p. 39-51 13 p.

Research output: Contribution to journalArticle

Open Access

A mutation-specific, single-arm, phase 2 study of dovitinib in patients with advanced malignancies

Taylor, M. H., Alva, A. S., Larson, T., Szpakowski, S., Purkaystha, D., Amin, A., Karpiak, L. & Piha-Paul, S. A., Apr 1 2020, In : Oncotarget. 11, 14, p. 1235-1243 9 p.

Research output: Contribution to journalArticle

Open Access

An Empirical Analysis of Noninferiority Studies in Oncology: Are They Good Enough?

Haslam, A., Gill, J. & Prasad, V., Feb 1 2020, In : Journal of the National Comprehensive Cancer Network : JNCCN. 18, 2, p. 161-167 7 p.

Research output: Contribution to journalArticle

A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease

Schroeder, M. A., Jean Khoury, H., Jagasia, M., Ali, H., Schiller, G. J., Staser, K., Choi, J., Gehrs, L., Arbushites, M. C., Yan, Y., Langmuir, P., Srinivas, N., Pratta, M., Perales, M. A., Chen, Y. B., Meyers, G. & DiPersio, J. F., Apr 28 2020, In : Blood Advances. 4, 8, p. 1657-1669 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A Phase II Basket Trial of Dual Anti–CTLA-4 and Anti–PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors

Patel, S. P., Othus, M., Chae, Y. K., Giles, F. J., Hansel, D. E., Singh, P. P., Fontaine, A., Shah, M. H., Kasi, A., Baghdadi, T. A., Matrana, M., Gatalica, Z., Korn, W. M., Hayward, J., McLeod, C., Chen, H. X., Sharon, E., Mayerson, E., Ryan, C. W., Plets, M. & 2 others, Blanke, C. D. & Kurzrock, R., May 15 2020, In : Clinical Cancer Research. 26, 10, p. 2290-2296 7 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone

Graff, J. N., Beer, T. M., Alumkal, J. J., Slottke, R. E., Redmond, W. L., Thomas, G. V., Thompson, R. F., Wood, M. A., Koguchi, Y., Chen, Y., Latour, E., Bergan, R. C., Drake, C. G. & Moran, A. E., Jul 1 2020, In : Journal for immunotherapy of cancer. 8, 2

Research output: Contribution to journalArticle

Open Access

Arti Hurria, M.D. A tribute to her shining legacy in the Alliance for Clinical Trials in Oncology

On behalf of the Alliance Cancer in the Older Adult Committee, Mar 2020, In : Journal of Geriatric Oncology. 11, 2, p. 179-183 5 p.

Research output: Contribution to journalShort survey

A simplified prognostic index for chronic lymphocytic leukemia treated with ibrutinib: Results from a multicenter retrospective cohort study

Gordon, M. J., Sitlinger, A., Salous, T., Alqahtani, H., Churnetski, M., Rivera, X., Wisniewski, P., Cohen, J., Patel, K., Shadman, M., Choi, M., Hill, B., Stephens, D., Persky, D., Brander, D. & Danilov, A. V., Feb 2020, In : Leukemia Research. 89, 106302.

Research output: Contribution to journalLetter

Association between New Unconfirmed Bone Lesions and Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer Treated with Enzalutamide: Secondary Analysis of the PREVAIL and AFFIRM Randomized Clinical Trials

Armstrong, A. J., Al-Adhami, M., Lin, P., Parli, T., Sugg, J., Steinberg, J., Tombal, B., Sternberg, C. N., De Bono, J., Scher, H. I. & Beer, T. M., Feb 2020, In : JAMA Oncology. 6, 2, p. 217-225 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Association of Patient Demographic Characteristics and Insurance Status With Survival in Cancer Randomized Clinical Trials With Positive Findings

Unger, J. M., Blanke, C. D., LeBlanc, M., Barlow, W. E., Vaidya, R., Ramsey, S. D. & Hershman, D. L., Apr 1 2020, In : JAMA Network Open. 3, 4, p. e203842

Research output: Contribution to journalArticle

Open Access

Association of the Coronavirus Disease 2019 (COVID-19) Outbreak With Enrollment in Cancer Clinical Trials

Unger, J. M., Blanke, C. D., LeBlanc, M. & Hershman, D. L., Jun 1 2020, In : JAMA Network Open. 3, 6, p. e2010651

Research output: Contribution to journalArticle

Open Access

Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial

Schmid, P., Rugo, H. S., Adams, S., Schneeweiss, A., Barrios, C. H., Iwata, H., Diéras, V., Henschel, V., Molinero, L., Chui, S. Y., Maiya, V., Husain, A., Winer, E. P., Loi, S. & Emens, L. A., Jan 2020, In : The Lancet Oncology. 21, 1, p. 44-59 16 p.

Research output: Contribution to journalArticle

32 Scopus citations

Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial

Heinrich, M. C., Jones, R. L., von Mehren, M., Schöffski, P., Serrano, C., Kang, Y. K., Cassier, P. A., Mir, O., Eskens, F., Tap, W. D., Rutkowski, P., Chawla, S. P., Trent, J., Tugnait, M., Evans, E. K., Lauz, T., Zhou, T., Roche, M., Wolf, B. B., Bauer, S. & 1 others, George, S., Jul 2020, In : The Lancet Oncology. 21, 7, p. 935-946 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Candidate biomarker assessment for pharmacological response

Reinhold, W. C., Elloumi, F., Varma, S., Robert, J., Mills, G. B. & Pommier, Y., Oct 2020, In : Translational Oncology. 13, 10, 100830.

Research output: Contribution to journalArticle

Open Access

Cell Death Pathways in Lymphoid Malignancies

Fletcher, L., Nabrinsky, E., Liu, T. & Danilov, A., Jan 1 2020, In : Current oncology reports. 22, 1, 10.

Research output: Contribution to journalReview article

1 Scopus citations

Chimeric Antigen Receptor T Cell Therapy During the COVID-19 Pandemic

The CAR T-cell Consortium, Jul 2020, In : Biology of Blood and Marrow Transplantation. 26, 7, p. 1239-1246 8 p.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Chronic Voluntary Ethanol Drinking in Cynomolgus Macaques Elicits Gene Expression Changes in Prefrontal Cortical Area 46

Walter, N. A. R., Zheng, C. L., Searles, R. P., McWeeney, S. K., Grant, K. A. & Hitzemann, R., Feb 1 2020, In : Alcoholism: Clinical and Experimental Research. 44, 2, p. 470-478 9 p.

Research output: Contribution to journalArticle

Open Access

Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers

Tuna, M., Ju, Z., Yoshihara, K., Amos, C. I., Tanyi, J. L. & Mills, G. B., Feb 4 2020, In : British Journal of Cancer. 122, 3, p. 405-412 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Combined inhibition of JAK/STAT pathway and lysine-specific demethylase 1 as a therapeutic strategy in CSF3R/CEBPA mutant acute myeloid leukemia

Braun, T. P., Coblentz, C., Smith, B. M., Coleman, D. J., Schonrock, Z., Carratt, S. A., Callahan, R. L., Maniaci, B., Druker, B. J. & Maxson, J. E., Jun 16 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 24, p. 13670-13679 10 p.

Research output: Contribution to journalArticle

Comparison of Drugs Used for Adjuvant and Metastatic Therapy of Colon, Breast, and Non-Small Cell Lung Cancers

Parsons, S., Maldonado, E. B. & Prasad, V., Apr 1 2020, In : JAMA Network Open. 3, 4, p. e202488

Research output: Contribution to journalArticle

Open Access

Comparison of Industry Payments in 2017 with Annual Salary in a Cohort of Academic Oncologists

Gill, J., Haslam, A., Crain, T., Herrera-Perez, D. & Prasad, V., May 2020, In : JAMA internal medicine. 180, 5, p. 797-799 3 p.

Research output: Contribution to journalLetter

1 Scopus citations

Comparison of Mortality Among Participants of Women's Health Initiative Trials With Screening-Detected Breast Cancers vs Interval Breast Cancers

Irvin, V. L., Zhang, Z., Simon, M. S., Chlebowski, R. T., Luoh, S-W., Shadyab, A. H., Krok-Schoen, J. L., Tabung, F. K., Qi, L., Stefanick, M. L., Schedin, P. & Jindal, S., Jun 1 2020, In : JAMA Network Open. 3, 6, p. e207227

Research output: Contribution to journalArticle

Open Access

Comparison of Real-Time Fluorescence Confocal Digital Microscopy With Hematoxylin-Eosin-Stained Sections of Core-Needle Biopsy Specimens

Krishnamurthy, S., Sabir, S., Ban, K., Wu, Y., Sheth, R., Tam, A., Meric-Bernstam, F., Shaw, K., Mills, G., Bassett, R., Hamilton, S., Hicks, M. & Gupta, S., Mar 2 2020, In : JAMA Network Open. 3, 3, p. e200476

Research output: Contribution to journalArticle

Open Access

Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

Noll, K. E., Whitmore, A. C., West, A., McCarthy, M. K., Morrison, C. R., Plante, K. S., Hampton, B. K., Kollmus, H., Pilzner, C., Leist, S. R., Gralinski, L. E., Menachery, V. D., Schäfer, A., Miller, D., Shaw, G., Mooney, M., McWeeney, S., Pardo-Manuel de Villena, F., Schughart, K., Morrison, T. E. & 3 others, Baric, R. S., Ferris, M. T. & Heise, M. T., Apr 28 2020, In : Cell Reports. 31, 4, 107587.

Research output: Contribution to journalArticle

Open Access

Comprehensive assessment of computational algorithms in predicting cancer driver mutations

Chen, H., Li, J., Wang, Y., Ng, P. K. S., Tsang, Y. H., Shaw, K. R., Mills, G. B. & Liang, H., Feb 20 2020, In : Genome biology. 21, 1, 43.

Research output: Contribution to journalArticle

Open Access

Correlative analyses of the SARC028 trial reveal an association between sarcoma-associated immune infiltrate and response to pembrolizumab

Keung, E. Z., Burgess, M., Salazar, R., Parra, E. R., Rodrigues-Canales, J., Bolejack, V., Van Tine, B. A., Schuetze, S. M., Attia, S., Riedel, R. F., Hu, J., Okuno, S. H., Priebat, D. A., Movva, S., Davis, L. E., Reed, D. R., Reuben, A., Roland, C. L., Reinke, D., Lazar, A. J. & 3 others, Wang, W. L., Wargo, J. A. & Tawbi, H. A., Mar 15 2020, In : Clinical Cancer Research. 26, 6, p. 1258-1266 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2 Scopus citations

Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma

Berlow, N. E., Grasso, C. S., Quist, M. J., Cheng, M., Gandour-Edwards, R., Hernandez, B. S., Michalek, J. E., Ryan, C., Spellman, P., Pal, R., Million, L. S., Renneker, M. & Keller, C., 2020, In : Sarcoma. 2020, 6312480.

Research output: Contribution to journalArticle

Open Access

De novo thrombotic microangiopathy in two kidney transplant recipients from the same deceased donor: A case series

Roberts, D., Siegman, I., Andeen, N., Woodland, D., Deloughery, T., Rueda, J., Olyaei, A., Rehman, S., Norman, D. & Lockridge, J., Jul 1 2020, In : Clinical Transplantation. 34, 7, e13885.

Research output: Contribution to journalArticle

Detecting rare diseases in electronic health records using machine learning and knowledge engineering: Case study of acute hepatic porphyria

Cohen, A. M., Chamberlin, S., Deloughery, T., Nguyen, M., Bedrick, S., Meninger, S., Ko, J. J., Amin, J. J., Wei, A. J. & Hersh, W., 2020, In : PloS one. 15, 7, p. e0235574

Research output: Contribution to journalArticle

Open Access

Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma

Berg, H. F., Ju, Z., Myrvold, M., Fasmer, K. E., Halle, M. K., Hoivik, E. A., Westin, S. N., Trovik, J., Haldorsen, I. S., Mills, G. B., Krakstad, C. & Werner, H. M. J., Jan 1 2020, (Accepted/In press) In : British Journal of Cancer.

Research output: Contribution to journalArticle

Diabetes and clinical outcome in patients with metastatic colorectal cancer: CALGB 80405 (Alliance)

Brown, J. C., Zhang, S., Ou, F. S., Venook, A. P., Niedzwiecki, D., Lenz, H. J., Innocenti, F., O'Neil, B. H., Shaw, J. E., Polite, B. N., Denlinger, C. S., Atkins, J. N., Goldberg, R. M., Ng, K., Mayer, R. J., Blanke, C. D., O'Reilly, E. M., Fuchs, C. S. & Meyerhardt, J. A., Feb 1 2020, In : JNCI Cancer Spectrum. 4, 1, pkz078.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

Tsang, Y. H., Wang, Y., Kong, K., Grzeskowiak, C., Zagorodna, O., Dogruluk, T., Lu, H., Villafane, N., Bhavana, V. H., Moreno, D., Elsea, S. H., Liang, H., Mills, G. B. & Scott, K. L., Apr 2020, In : eLife. 9, e48963.

Research output: Contribution to journalArticle

Open Access

Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

Joshi, S. K., Qian, K., Bisson, W. H., Watanabe-Smith, K., Huang, A., Bottomly, D., Traer, E., Tyner, J. W., McWeeney, S. K., Davare, M. A., Druker, B. J. & Tognon, C. E., Jun 11 2020, In : Blood. 135, 24, p. 2159-2170 12 p.

Research output: Contribution to journalArticle

Down-regulation of ADRB2 expression is associated with small cell neuroendocrine prostate cancer and adverse clinical outcomes in castration-resistant prostate cancer

Kwon, D. H., Zhang, L., Quigley, D. A., Foye, A., Chen, W. S., Wong, C. K., Feng, F. Y., Bailey, A., Huang, J., Stuart, J. M., Friedl, V., Weinstein, A. S., Beer, T. M., Alumkal, J., Rettig, M., Gleave, M., Lara, P. N., Thomas, G. V., Li, P., Lui, A. & 2 others, Small, E. J. & Aggarwal, R. R., 2020, (Accepted/In press) In : Urologic Oncology: Seminars and Original Investigations.

Research output: Contribution to journalArticle

Downregulation of the ubiquitin-e3 ligase rnf123 promotes upregulation of the nf-κb1 target serpine1 in aggressive glioblastoma tumors

Wang, X., Bustos, M. A., Zhang, X., Ramos, R. I., Tan, C., Iida, Y., Chang, S. C., Salomon, M. P., Tran, K., Gentry, R., Kravtsova-Ivantsiv, Y., Kelly, D. F., Mills, G. B., Ciechanover, A., Mao, Y. & Hoon, D. S. B., May 2020, In : Cancers. 12, 5, 1081.

Research output: Contribution to journalArticle

Open Access

Effect of Time to Surgery of Colorectal Liver Metastases on Survival

Chen, E. Y., Mayo, S. C., Sutton, T., Kearney, M. R., Kardosh, A., Vaccaro, G. M., Billingsley, K. G. & Lopez, C. D., Jan 1 2020, (Accepted/In press) In : Journal of Gastrointestinal Cancer.

Research output: Contribution to journalArticle

Open Access

Electrochemical attack and corrosion of platinum electrodes in dielectrophoretic diagnostic devices

Heineck, D. P., Sarno, B., Kim, S. & Heller, M., Jan 1 2020, (Accepted/In press) In : Analytical and Bioanalytical Chemistry.

Research output: Contribution to journalArticle

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer

Prasad, V., Feb 27 2020, In : The New England journal of medicine. 382, 9, 1 p.

Research output: Contribution to journalLetter

Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era

Roth, M. E., Unger, J. M., O'Mara, A. M., Lewis, M. A., Budd, T., Johnson, R. H., Pollock, B. H., Blanke, C. & Freyer, D. R., Mar 1 2020, In : Cancer medicine. 9, 6, p. 2146-2152 7 p.

Research output: Contribution to journalArticle

Open Access

ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia

Joshi, S. K., Keck, J. M., Eide, C. A., Bottomly, D., Traer, E., Tyner, J. W., McWeeney, S., Tognon, C. E. & Druker, B. J., Jan 1 2020, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Open Access

Estimation of the Percentage of US Patients With Cancer Who Are Eligible for Immune Checkpoint Inhibitor Drugs

Haslam, A., Gill, J. & Prasad, V., Mar 2 2020, In : JAMA Network Open. 3, 3, p. e200423

Research output: Contribution to journalArticle

Open Access

Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD

Nigg, J. T., Karalunas, S. L., Gustafsson, H. C., Bhatt, P., Ryabinin, P., Mooney, M. A., Faraone, S. V., Fair, D. A. & Wilmot, B., Feb 1 2020, In : Journal of Child Psychology and Psychiatry and Allied Disciplines. 61, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

FDA Acceptance of Surrogate End Points for Cancer Drug Approval: 1992-2019

Chen, E. Y., Haslam, A. & Prasad, V., Jun 2020, In : JAMA internal medicine. 180, 6, p. 912-914 3 p.

Research output: Contribution to journalLetter

Open Access
3 Scopus citations