Knight Cancer Institute

Research Output 1966 2020

2020
Single-Cell Analysis
Tumor-Infiltrating Lymphocytes
Fluorescent Antibody Technique
Breast Neoplasms
Neoplasms

Immune Thrombocytopenic Purpura Splenectomy in the Context of New Medical Therapies

Worrest, T., Cunningham, A., Dewey, E., Deloughery, T., Gilbert, E., Sheppard, B. & Fischer, L. E., Jan 1 2020, In : Journal of Surgical Research. 245, p. 643-648 6 p.

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura
Splenectomy
Therapeutics
Adrenal Insufficiency
Platelet Count
2019

A case of recurrent epilepsy-associated rosette-forming glioneuronal tumor with anaplastic transformation in the absence of therapy

Halfpenny, A., Ferris, S. P., Grafe, M., Woltjer, R. R., Selden, N., Nazemi, K., Perry, A., Solomon, D. A., Gultekin, S., Moore, S., Olson, S., Lawce, H., Lucas, L., Corless, C. & Wood, M., Jan 1 2019, (Accepted/In press) In : Neuropathology.

Research output: Contribution to journalArticle

Open Access
Epilepsy
Neuroepithelial Neoplasms
Fluorescence In Situ Hybridization
Neoplasms
Temporal Lobe
3 Citations (Scopus)

A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

Herrera-Perez, D., Haslam, A., Crain, T., Gill, J., Livingston, C., Kaestner, V., Hayes, M., Morgan, D., Cifu, A. S. & Prasad, V., Jun 11 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
New England
American Medical Association
Medicine
Cardiovascular Diseases
Randomized Controlled Trials
8 Citations (Scopus)

Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

Allen-Petersen, B. L., Risom, T., Feng, Z., Wang, Z., Jenny, Z. P., Thoma, M. C., Pelz, K. R., Morton, J. P., Sansom, O. J., Lopez, C., Sheppard, B., Christensen, D. J., Ohlmeyer, M., Narla, G. & Sears, R., Jan 1 2019, In : Cancer Research. 79, 1, p. 209-219 11 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Adenocarcinoma
Phosphoric Monoester Hydrolases
Phosphotransferases
Growth
Open Access
Myelodysplastic Syndromes
Homologous Transplantation
Acute Myeloid Leukemia
Hematopoietic Stem Cell Transplantation
Transplantation

Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemia

Schittenhelm, M. M., Walter, B., Tsintari, V., Federmann, B., Bajrami Saipi, M., Akmut, F., Illing, B., Mau-Holzmann, U., Fend, F., Lopez, C. & Kampa-Schittenhelm, K. M., Apr 1 2019, In : EBioMedicine. 42, p. 340-351 12 p.

Research output: Contribution to journalArticle

Open Access
Tumor Suppressor Protein p53
Alternative Splicing
Tumors
Protein Isoforms
Leukemia
1 Citation (Scopus)

Anal intraepithelial neoplasia: Diagnosis, screening, and treatment

Siddharthana, R. V., Lanciault, C. & Tsikitis, V., May 3 2019, In : Annals of Gastroenterology. 32, 3, p. 257-263 7 p.

Research output: Contribution to journalArticle

Open Access
Papillomaviridae
Anus Neoplasms
Virus Diseases
Neoplasms
Therapeutics
1 Citation (Scopus)
Drug Approval
Quality Control
Randomized Controlled Trials
Standard of Care
Antineoplastic Agents
Radiation Oncology
Internship and Residency
Publications
Research
Career Choice
2 Citations (Scopus)
United States Food and Drug Administration
Biomarkers
Drug Approval
Pharmaceutical Preparations
Neoplasms

A phase 2 study to assess the pharmacokinetics and pharmacodynamics of CPX-351 and its effects on cardiac repolarization in patients with acute leukemias

Lin, T. L., Newell, L., Stuart, R. K., Michaelis, L. C., Rubenstein, E., Pentikis, H. S., Callahan, T., Alvarez, D., Liboiron, B. D., Mayer, L. D., Wang, Q., Banerjee, K. & Louie, A. C., Jan 1 2019, In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

Open Access
Pharmacodynamics
Daunorubicin
Pharmacokinetics
Leukemia
Cytarabine

A phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA)

Kapoor, R., Deek, M. P., McIntyre, R., Raman, N., Kummerlowe, M., Chen, I., Gaver, M., Wang, H., Denmeade, S., Lotan, T., Paller, C., Markowski, M., Carducci, M., Eisenberger, M., Beer, T. T., Song, D. Y., Deweese, T. L., Hearn, J. W., Greco, S., Deville, C. & 7 others, Desai, N. B., Heath, E. I., Liauw, S., Spratt, D. E., Hung, A., Antonarakis, E. S. & Tran, P. T., Jun 13 2019, In : BMC cancer. 19, 1, 572.

Research output: Contribution to journalArticle

Open Access
Salvage Therapy
Prostatectomy
Double-Blind Method
Prostatic Neoplasms
Radiotherapy

A Phase II Study Alternating Erlotinib With Second-line mFOLFOX6 or FOLFIRI for Metastatic Colorectal Cancer

Kearney, M. R., Chen, E. Y., Vaccaro, G., Strother, J., Burt, A., Todd, K., Donovan, J., Kampa-Schittenhelm, K. M. & Lopez, C., Jan 1 2019, In : Anticancer Research. 39, 1, p. 245-252 8 p.

Research output: Contribution to journalArticle

irinotecan
Colorectal Neoplasms
oxaliplatin
Neutropenia
Combination Drug Therapy

A Pilot Proof-Of-Principle Analysis Demonstrating Dielectrophoresis (DEP) as a Glioblastoma Biomarker Platform

Lewis, J., Alattar, A. A., Akers, J., Carter, B. S., Heller, M. M. & Chen, C. C., Dec 1 2019, In : Scientific Reports. 9, 1, 10279.

Research output: Contribution to journalArticle

Open Access
Glioblastoma
Biomarkers
Glial Fibrillary Acidic Protein
Brain Neoplasms
Area Under Curve
1 Citation (Scopus)
Appendiceal Neoplasms
Appendicitis
Medicare
Diagnostic Errors
Epidemiology

A Qualitative Study of Serious Illness Conversations in Patients with Advanced Cancer

Geerse, O. P., Lamas, D. J., Sanders, J. J., Paladino, J., Kavanagh, J., Henrich, N. J., Berendsen, A. J., Hiltermann, T. J. N., Fromme, E., Bernacki, R. E. & Block, S. D., Jul 1 2019, In : Journal of palliative medicine. 22, 7, p. 773-781 9 p.

Research output: Contribution to journalArticle

Neoplasms
Terminal Care
Emotions
Outpatients
Randomized Controlled Trials

A reality check of the accelerated approval of immune-checkpoint inhibitors

Gill, J. & Prasad, V., Jan 1 2019, (Accepted/In press) In : Nature Reviews Clinical Oncology.

Research output: Contribution to journalComment/debate

Endoscopy
Benchmarking
Conflict of Interest
Glioblastoma
Neoplasms
Equipment and Supplies
Registries

Association of Antiepileptic Medications with Outcomes after Allogeneic Hematopoietic Cell Transplantation with Busulfan/Cyclophosphamide Conditioning

McCune, J. S., Wang, T., Bo-Subait, K., Aljurf, M., Beitinjaneh, A., Bubalo, J., Cahn, J. Y., Cerny, J., Chhabra, S., Cumpston, A., Dupuis, L. L., Lazarus, H. M., Marks, D. I., Maziarz, R., Norkin, M., Prestidge, T., Mineishi, S., Krem, M. M., Pasquini, M. & Martin, P. J., Jan 1 2019, In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalArticle

Busulfan
Cell Transplantation
Phenytoin
Anticonvulsants
Cyclophosphamide

Association of National Cancer Institute-Sponsored Clinical Trial Network Group Studies With Guideline Care and New Drug Indications

Unger, J. M., Nghiem, V. T., Hershman, D. L., Vaidya, R., LeBlanc, M. & Blanke, C., Sep 4 2019, In : JAMA Network Open. 2, 9, p. e1910593

Research output: Contribution to journalArticle

Open Access
Drug Approval
National Cancer Institute (U.S.)
Clinical Trials
Guidelines
Pharmaceutical Preparations

A systematic review of head-to-head trials of approved monoclonal antibodies used in cancer: an overview of the clinical trials agenda

Luo, J., Nishikawa, G. & Prasad, V., Sep 4 2019, In : Journal of Cancer Research and Clinical Oncology. 145, 9, p. 2303-2311 9 p.

Research output: Contribution to journalReview article

Meta-Analysis
Monoclonal Antibodies
Neoplasms
Ligands
Pharmaceutical Preparations
12 Citations (Scopus)

A systematic review of trial-level meta-analyses measuring the strength of association between surrogate end-points and overall survival in oncology

Haslam, A., Hey, S. P., Gill, J. & Prasad, V., Jan 1 2019, In : European Journal of Cancer. 106, p. 196-211 16 p.

Research output: Contribution to journalReview article

Meta-Analysis
Validation Studies
Biomarkers
Survival
Randomized Controlled Trials
3 Citations (Scopus)

Avelumab in patients with previously treated metastatic melanoma: Phase 1b results from the JAVELIN Solid Tumor trial

Keilholz, U., Mehnert, J. M., Bauer, S., Bourgeois, H., Patel, M. R., Gravenor, D., Nemunaitis, J. J., Taylor, M., Wyrwicz, L., Lee, K. W., Kasturi, V., Chin, K., Von Heydebreck, A. & Gulley, J. L., Jan 16 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 12.

Research output: Contribution to journalArticle

Melanoma
Neoplasms
Therapeutics
Disease-Free Survival
Survival

Benign Anal Disease: Implementation of an Educational Program Across Specialties

Kelley, K. A., Schulman, C., Lu, K. & Tsikitis, V., Nov 1 2019, In : Journal of Surgical Research. 243, p. 249-254 6 p.

Research output: Contribution to journalArticle

Internal Medicine
Rectal Diseases
Institutional Practice
Medicine
Surgical Specialties

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

Coleman, D. J., Gao, L., King, C. J., Schwartzman, J., Urrutia, J., Sehrawat, A., Tayou, J., Balter, A., Burchard, J., Chiotti, K. E., Derrick, D. S., Sun, D., Xia, Z., Heiser, L. & Alumkal, J., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Androgen Receptors
Castration
Prostatic Neoplasms
RNA Sequence Analysis
Neoplasms
1 Citation (Scopus)

Biomarker results from a phase II study of MEK1/2 inhibitor binimetinib (MEK162) in patients with advanced NRAS- or BRAF-mutated melanoma

Van Herpen, C. M. L., Agarwala, S. S., Hauschild, A., Berking, C., Thaddeus Beck, J., Schadendorf, D., Jansen, R., Queirolo, P., Ascierto, P. A., Blank, C. U., Heinrich, M., Pal, R. R., Derti, A., Antona, V., Nauwelaerts, H., Zubel, A. & Dummer, R., Mar 1 2019, In : Oncotarget. 10, 19, p. 1850-1859 10 p.

Research output: Contribution to journalArticle

Melanoma
Biomarkers
Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase Kinases
Mutation

Biopsy-proven thrombotic microangiopathy without schistocytosis on peripheral blood smear: A cautionary tale

Murphree, C. R., Nguyen, N. N., Shatzel, J. J., Olson, S. R., Chung, P. D., Lockridge, J. B., Andeen, N. & Deloughery, T., Jan 1 2019, In : American Journal of Hematology.

Research output: Contribution to journalLetter

Open Access
Thrombotic Microangiopathies
Biopsy
1 Citation (Scopus)

Cancer screening: A modest proposal for prevention

Kim, M. S., Nishikawa, G. & Prasad, V., Mar 1 2019, In : Cleveland Clinic journal of medicine. 86, 3, p. 157-160 4 p.

Research output: Contribution to journalComment/debate

Open Access
Early Detection of Cancer

Case Reports in the Age of Twitter

Cifu, A. S., Vandross, A. L. & Prasad, V., Jan 1 2019, In : American Journal of Medicine.

Research output: Contribution to journalEditorial

Open Access

Cells tagged near an early spread of cancer

Labat, M-L., Aug 1 2019, In : Nature. 572, 7771, p. 589-590 2 p.

Research output: Contribution to journalComment/debate

Open Access

Challenges and approaches to implementing master/basket trials in oncology

Burd, A., Schilsky, R. L., Byrd, J. C., Levine, R. L., Papadimitrakopoulou, V. A., Herbst, R. S., Redman, M. W., Druker, B. & Gandara, D. R., Jul 23 2019, In : Blood Advances. 3, 14, p. 2237-2243 7 p.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Research Personnel
Appetite
Epigenomics
Health Personnel
1 Citation (Scopus)

Circulating tumor DNA dynamics using patient-customized assays are associated with outcome in neoadjuvantly treated breast cancer

Butler, T. M., Boniface, C. T., Johnson-Camacho, K., Tabatabaei, S., Melendez, D., Kelley, T., Gray, J., Corless, C. & Spellman, P., Apr 1 2019, In : Cold Spring Harbor molecular case studies. 5, 2

Research output: Contribution to journalArticle

Open Access
Chemotherapy
Tumors
Assays
Breast Neoplasms
Drug Therapy

Clinical Management of Pharmacokinetic Drug Interactions with Direct Oral Anticoagulants (DOACs)

Herink, M. C., Zhuo, Y. F., Williams, C. D. & Deloughery, T., Jan 1 2019, (Accepted/In press) In : Drugs.

Research output: Contribution to journalReview article

Drug Interactions
Anticoagulants
Pharmacokinetics
Warfarin
Serum
Inpatients
Databases
Patient Acceptance of Health Care
Research
Organizations
6 Citations (Scopus)

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. & Tyner, J., Dec 1 2019, In : Nature Communications. 10, 1, 244.

Research output: Contribution to journalArticle

leukemias
mutations
Acute Myeloid Leukemia
Mutation
inhibitors

Colloids, nanoparticles, and materials for imaging, delivery, ablation, and theranostics by focused ultrasound (FUS)

Yildirim, A., Blum, N. T. & Goodwin, A. P., Jan 1 2019, In : Theranostics. 9, 9, p. 2572-2594 23 p.

Research output: Contribution to journalArticle

Open Access
Colloids
Acoustics
Nanoparticles
Contrast Media
Microbubbles

Combining options in metastatic prostate cancer

Kopp, R. & Beer, T. T., Jan 1 2019, In : Nature Reviews Urology.

Research output: Contribution to journalComment/debate

Prostatic Neoplasms
docetaxel
Therapeutics
1 Citation (Scopus)

Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours

Serrano, C., Mariño-Enríquez, A., Tao, D. L., Ketzer, J., Eilers, G., Zhu, M., Yu, C., Mannan, A. M., Rubin, B. P., Demetri, G. D., Raut, C. P., Presnell, A., McKinley, A., Heinrich, M., Czaplinski, J. T., Sicinska, E., Bauer, S., George, S. & Fletcher, J. A., Mar 19 2019, In : British Journal of Cancer. 120, 6, p. 612-620 9 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Protein-Tyrosine Kinases
Mutation
Clinical Trials
Growth

Confirmatory Trials for Drugs Approved on a Single Trial

Haslam, A. & Prasad, V., Jun 1 2019, In : Circulation. Cardiovascular quality and outcomes. 12, 6, p. e005494

Research output: Contribution to journalArticle

Valsartan
Drug Approval
Fish Oils
Pharmaceutical Preparations

Correction: A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory (Oncotarget (2017) 8 (41806-41814) DOI: 10.18632/oncotarget.16018

Arango, N. P., Brusco, L., Shaw, K. R. M., Chen, K., Eterovic, A. K., Holla, V., Johnson, A., Litzenburger, B., Khotskaya, Y. B., Sanchez, N., Bailey, A., Zheng, X., Horombe, C., Kopetz, S., Farhangfar, C. J., Routbort, M., Broaddus, R., Bernstam, E. V., Mendelsohn, J., Mills, G. & 1 others, Meric-Bernstam, F., Jan 1 2019, In : Oncotarget. 10, 50, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Feasibility Studies
Research

Correction: 33rd Annual meeting & pre-conference programs of the Society for Immunotherapy of Cancer (SITC 2018) (Journal for ImmunoTherapy of Cancer (2018) 6:Suppl 1 DOI: 10.1186/s40425-018-0422-y)

Berry, S., Giraldo, N., Nguyen, P., Green, B., Xu, H., Ogurtsova, A., Soni, A., Succaria, F., Wang, D., Roberts, C., Stein, J., Engle, E., Pardoll, D., Anders, R., Cottrell, T., Taube, J. M., Tran, B., Voskoboynik, M., Kuo, J., Bang, Y. L. & 72 others, Chung, H. C., Ahn, M. J., Kim, S. W., Perera, A., Freeman, D., Achour, I., Faggioni, R., Xiao, F., Ferte, C., Lemech, C., Meric-Bernstam, F., Werner, T., Hodi, S., Messersmith, W., Lewis, N., Talluto, C., Dostalek, M., Tao, A., McWhirter, S., Trujillo, D., Luke, J., Xu, C., Bomarelli, B., Qi, J., Qin, G., Yu, H., Jenkins, M., Lo, K. M., Halle, J. P., Lan, Y., Taylor, M., Vogelzang, N., Cohn, A., Stepan, D., Shumaker, R., Dutcus, C., Guo, M., Schmidt, E., Rasco, D., Brose, M., Di Simone, C., Jain, S., Richards, D., Encarnacion, C., Vogelzeng, N., Mier, J., An, J., Yang, Y. Y., Lee, W. H., Yang, J., Kim, J. K., Kim, H. G., Paek, S. H., Lee, J. W., Woo, J., Kim, J. B., Kwon, H., Lim, W., Paik, N. S., Kim, Y. K., Moon, B. I., Janku, F., Tan, D., Martin-Liberal, J., Takahashi, S., Geva, R., Gucalp, A., Chen, X., Subramanian, K., Mataraza, J., Wheler, J. & Bedard, P., Feb 13 2019, In : Journal for immunotherapy of cancer. 7, 1, 46.

Research output: Contribution to journalArticle

Open Access
Immunotherapy
Publications
Neoplasms

Correction: First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL (Oncotarget(2018) 9 (13023 -13035) DOI: 10.18632/oncotarget.24310)

Byrd, J. C., Smith, S., Wagner-Johnston, N., Sharman, J., Chen, A., Advani, R., Augustson, B., Marlton, P., Renee Commerford, S., Okrah, K., Liu, L., Murray, E., Penuel, E., Ward, A. F. & Flinn, I. W., Jan 1 2019, In : Oncotarget. 10, 38, p. 3827-3830 4 p.

Research output: Contribution to journalComment/debate

Open Access
B-Lymphocytes

Correction: Epigenetic therapy with panobinostat combined with bicalutamide rechallenge in castration-resistant prostate cancer (Clinical Cancer Research (2019) 25 (52-63) DOI: 10.1158/1078-0432.CCR-18-1589)

Ferrari, A. C., Alumkal, J., Stein, M. N., Taplin, M. E., Babb, J., Barnett, E. S., Gomez-Pinillos, A., Liu, X., Moore, D., DiPaola, R. & Beer, T. T., Apr 15 2019, In : Clinical Cancer Research. 25, 8, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Castration
Epigenomics
Prostatic Neoplasms
Emotions
Research

Correction: Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours (British Journal of Cancer, (2019), 120, 6, (612-620), 10.1038/s41416-019-0389-6)

Serrano, C., Mariño-Enríquez, A., Tao, D. L., Ketzer, J., Eilers, G., Zhu, M., Yu, C., Mannan, A. M., Rubin, B. P., Demetri, G. D., Raut, C. P., Presnell, A., McKinley, A., Heinrich, M., Czaplinski, J. T., Sicinska, E., Bauer, S., George, S. & Fletcher, J. A., Jan 1 2019, In : British Journal of Cancer.

Research output: Contribution to journalComment/debate

Open Access
Gastrointestinal Stromal Tumors
Expert Testimony
Protein-Tyrosine Kinases
Mutation
Pharmaceutical Preparations
3 Citations (Scopus)

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E., Kaempf, A., Mori, M. T., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. & Tyner, J., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Acute Myeloid Leukemia
Macrophage Colony-Stimulating Factor
Cytokines
Cells

Current Activities of the Coalition of Cancer Cooperative Groups

Coalition of Cancer Cooperative Groups, Jan 1 2019, In : Journal of the National Cancer Institute. 111, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

Clinical Trials
Research
National Cancer Institute (U.S.)
Neoplasms
Private Sector

Cyclin-dependent kinase-9 is a therapeutic target in MYC-expressing diffuse large B-cell lymphoma

Hashiguchi, T., Bruss, N., Best, S., Lam, V., Danilova, O., Paiva, C. J., Wolf, J., Gilbert, E. W., Okada, C., Kaur, P., Drew, L., Cidado, J., Hurlin, P. & Danilov, A., Jan 1 2019, In : Molecular cancer therapeutics. 18, 9, p. 1520-1532 13 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 9
Lymphoma, Large B-Cell, Diffuse
Cyclin T
Down-Regulation
Personnel Selection
1 Citation (Scopus)

Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer

Li, X., Mak, V. C. Y., Zhou, Y., Wang, C., Wong, E. S. Y., Sharma, R., Lu, Y., Cheung, A. N. Y., Mills, G. & Cheung, L. W. T., Dec 1 2019, In : Nature communications. 10, 1, 716.

Research output: Contribution to journalArticle

Open Access
phosphorylation
Phosphorylation
Ovarian Neoplasms
cancer
Tumors