Knight Cancer Institute

Research Output

2020

A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti-PD-1 antibody, in patients with advanced solid tumors

Naing, A., Gainor, J. F., Gelderblom, H., Forde, P. M., Butler, M. O., Lin, C. C., Sharma, S., Ochoa De Olza, M., Varga, A., Taylor, M., Schellens, J. H. M., Wu, H., Sun, H., Silva, A. P., Faris, J., Mataraza, J., Cameron, S. & Bauer, T. M., Mar 15 2020, In : Journal for immunotherapy of cancer. 8, 1, e000530.

Research output: Contribution to journalArticle

Open Access

A multifunctional therapy approach for cancer: Targeting Raf1- Mediated inhibition of cell motility, growth, and interaction with the microenvironment

Zhang, L., Pattanayak, A., Li, W., Ko, H. K., Fowler, G., Gordon, R. & Bergan, R., Jan 1 2020, In : Molecular cancer therapeutics. 19, 1, p. 39-51 13 p.

Research output: Contribution to journalArticle

Open Access

An Empirical Analysis of Noninferiority Studies in Oncology: Are They Good Enough?

Haslam, A., Gill, J. & Prasad, V., Feb 1 2020, In : Journal of the National Comprehensive Cancer Network : JNCCN. 18, 2, p. 161-167 7 p.

Research output: Contribution to journalArticle

A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease

Schroeder, M. A., Jean Khoury, H., Jagasia, M., Ali, H., Schiller, G. J., Staser, K., Choi, J., Gehrs, L., Arbushites, M. C., Yan, Y., Langmuir, P., Srinivas, N., Pratta, M., Perales, M. A., Chen, Y. B., Meyers, G. & DiPersio, J. F., Apr 28 2020, In : Blood Advances. 4, 8, p. 1657-1669 13 p.

Research output: Contribution to journalArticle

Open Access

Arti Hurria, M.D. A tribute to her shining legacy in the Alliance for Clinical Trials in Oncology

On behalf of the Alliance Cancer in the Older Adult Committee, Mar 2020, In : Journal of Geriatric Oncology. 11, 2, p. 179-183 5 p.

Research output: Contribution to journalShort survey

A simplified prognostic index for chronic lymphocytic leukemia treated with ibrutinib: Results from a multicenter retrospective cohort study

Gordon, M. J., Sitlinger, A., Salous, T., Alqahtani, H., Churnetski, M., Rivera, X., Wisniewski, P., Cohen, J., Patel, K., Shadman, M., Choi, M., Hill, B., Stephens, D., Persky, D., Brander, D. & Danilov, A. V., Feb 2020, In : Leukemia Research. 89, 106302.

Research output: Contribution to journalLetter

Association between New Unconfirmed Bone Lesions and Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer Treated with Enzalutamide: Secondary Analysis of the PREVAIL and AFFIRM Randomized Clinical Trials

Armstrong, A. J., Al-Adhami, M., Lin, P., Parli, T., Sugg, J., Steinberg, J., Tombal, B., Sternberg, C. N., De Bono, J., Scher, H. I. & Beer, T. M., Feb 2020, In : JAMA Oncology. 6, 2, p. 217-225 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial

Schmid, P., Rugo, H. S., Adams, S., Schneeweiss, A., Barrios, C. H., Iwata, H., Diéras, V., Henschel, V., Molinero, L., Chui, S. Y., Maiya, V., Husain, A., Winer, E. P., Loi, S. & Emens, L. A., Jan 2020, In : The Lancet Oncology. 21, 1, p. 44-59 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cell Death Pathways in Lymphoid Malignancies

Fletcher, L., Nabrinsky, E., Liu, T. & Danilov, A., Jan 1 2020, In : Current oncology reports. 22, 1, 10.

Research output: Contribution to journalReview article

Chimeric Antigen Receptor T Cell Therapy During the COVID-19 Pandemic

The CAR T-cell Consortium, Jan 1 2020, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalReview article

Open Access

Chronic Voluntary Ethanol Drinking in Cynomolgus Macaques Elicits Gene Expression Changes in Prefrontal Cortical Area 46

Walter, N. A. R., Zheng, C. L., Searles, R. P., McWeeney, S. K., Grant, K. A. & Hitzemann, R., Feb 1 2020, In : Alcoholism: Clinical and Experimental Research. 44, 2, p. 470-478 9 p.

Research output: Contribution to journalArticle

Open Access

Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers

Tuna, M., Ju, Z., Yoshihara, K., Amos, C. I., Tanyi, J. L. & Mills, G. B., Feb 4 2020, In : British Journal of Cancer. 122, 3, p. 405-412 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Comparison of Drugs Used for Adjuvant and Metastatic Therapy of Colon, Breast, and Non-Small Cell Lung Cancers

Parsons, S., Maldonado, E. B. & Prasad, V., Apr 1 2020, In : JAMA Network Open. 3, 4, p. e202488

Research output: Contribution to journalArticle

Open Access

Comparison of industry payments in 2017 with annual salary in a cohort of academic oncologists

Gill, J., Haslam, A., Crain, T., Herrera-Perez, D. & Prasad, V., Jan 1 2020, (Accepted/In press) In : JAMA internal medicine.

Research output: Contribution to journalLetter

Comparison of Real-Time Fluorescence Confocal Digital Microscopy With Hematoxylin-Eosin-Stained Sections of Core-Needle Biopsy Specimens

Krishnamurthy, S., Sabir, S., Ban, K., Wu, Y., Sheth, R., Tam, A., Meric-Bernstam, F., Shaw, K., Mills, G., Bassett, R., Hamilton, S., Hicks, M. & Gupta, S., Mar 2 2020, In : JAMA Network Open. 3, 3, p. e200476

Research output: Contribution to journalArticle

Open Access

Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

Noll, K. E., Whitmore, A. C., West, A., McCarthy, M. K., Morrison, C. R., Plante, K. S., Hampton, B. K., Kollmus, H., Pilzner, C., Leist, S. R., Gralinski, L. E., Menachery, V. D., Schäfer, A., Miller, D., Shaw, G., Mooney, M., McWeeney, S., Pardo-Manuel de Villena, F., Schughart, K., Morrison, T. E. & 3 others, Baric, R. S., Ferris, M. T. & Heise, M. T., Apr 28 2020, In : Cell Reports. 31, 4, 107587.

Research output: Contribution to journalArticle

Open Access

Comprehensive assessment of computational algorithms in predicting cancer driver mutations

Chen, H., Li, J., Wang, Y., Ng, P. K. S., Tsang, Y. H., Shaw, K. R., Mills, G. B. & Liang, H., Feb 20 2020, In : Genome biology. 21, 1, 43.

Research output: Contribution to journalArticle

Open Access

Correlative analyses of the SARC028 trial reveal an association between sarcoma-associated immune infiltrate and response to pembrolizumab

Keung, E. Z., Burgess, M., Salazar, R., Parra, E. R., Rodrigues-Canales, J., Bolejack, V., Van Tine, B. A., Schuetze, S. M., Attia, S., Riedel, R. F., Hu, J., Okuno, S. H., Priebat, D. A., Movva, S., Davis, L. E., Reed, D. R., Reuben, A., Roland, C. L., Reinke, D., Lazar, A. J. & 3 others, Wang, W. L., Wargo, J. A. & Tawbi, H. A., Mar 15 2020, In : Clinical Cancer Research. 26, 6, p. 1258-1266 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma

Berg, H. F., Ju, Z., Myrvold, M., Fasmer, K. E., Halle, M. K., Hoivik, E. A., Westin, S. N., Trovik, J., Haldorsen, I. S., Mills, G. B., Krakstad, C. & Werner, H. M. J., Jan 1 2020, (Accepted/In press) In : British Journal of Cancer.

Research output: Contribution to journalArticle

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

Tsang, Y. H., Wang, Y., Kong, K., Grzeskowiak, C., Zagorodna, O., Dogruluk, T., Lu, H., Villafane, N., Bhavana, V. H., Moreno, D., Elsea, S. H., Liang, H., Mills, G. B. & Scott, K. L., Apr 2020, In : eLife. 9, e48963.

Research output: Contribution to journalArticle

Open Access

Downregulation of the ubiquitin-e3 ligase rnf123 promotes upregulation of the nf-κb1 target serpine1 in aggressive glioblastoma tumors

Wang, X., Bustos, M. A., Zhang, X., Ramos, R. I., Tan, C., Iida, Y., Chang, S. C., Salomon, M. P., Tran, K., Gentry, R., Kravtsova-Ivantsiv, Y., Kelly, D. F., Mills, G. B., Ciechanover, A., Mao, Y. & Hoon, D. S. B., May 2020, In : Cancers. 12, 5, 1081.

Research output: Contribution to journalArticle

Open Access

Effect of Time to Surgery of Colorectal Liver Metastases on Survival

Chen, E. Y., Mayo, S. C., Sutton, T., Kearney, M. R., Kardosh, A., Vaccaro, G. M., Billingsley, K. G. & Lopez, C. D., Jan 1 2020, (Accepted/In press) In : Journal of Gastrointestinal Cancer.

Research output: Contribution to journalArticle

Open Access

Electrochemical attack and corrosion of platinum electrodes in dielectrophoretic diagnostic devices

Heineck, D. P., Sarno, B., Kim, S. & Heller, M., Jan 1 2020, (Accepted/In press) In : Analytical and Bioanalytical Chemistry.

Research output: Contribution to journalArticle

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer

Prasad, V., Feb 27 2020, In : The New England journal of medicine. 382, 9, 1 p.

Research output: Contribution to journalLetter

Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era

Roth, M. E., Unger, J. M., O'Mara, A. M., Lewis, M. A., Budd, T., Johnson, R. H., Pollock, B. H., Blanke, C. & Freyer, D. R., Mar 1 2020, In : Cancer medicine. 9, 6, p. 2146-2152 7 p.

Research output: Contribution to journalArticle

Open Access

Estimation of the Percentage of US Patients With Cancer Who Are Eligible for Immune Checkpoint Inhibitor Drugs

Haslam, A., Gill, J. & Prasad, V., Mar 2 2020, In : JAMA Network Open. 3, 3, p. e200423

Research output: Contribution to journalArticle

Open Access

Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD

Nigg, J. T., Karalunas, S. L., Gustafsson, H. C., Bhatt, P., Ryabinin, P., Mooney, M. A., Faraone, S. V., Fair, D. A. & Wilmot, B., Feb 1 2020, In : Journal of Child Psychology and Psychiatry and Allied Disciplines. 61, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

FDA Acceptance of Surrogate End Points for Cancer Drug Approval: 1992-2019

Chen, E. Y., Haslam, A. & Prasad, V., Jan 1 2020, (Accepted/In press) In : JAMA internal medicine.

Research output: Contribution to journalLetter

Open Access

Frequency of Medical Reversal Among Published Randomized Controlled Trials Assessing Cardiopulmonary Resuscitation (CPR)

Herrera-Perez, D., Fox-Lee, R., Bien, J. & Prasad, V., May 2020, In : Mayo Clinic Proceedings. 95, 5, p. 889-910 22 p.

Research output: Contribution to journalArticle

Open Access

Functional characterization of two rare BCR-FGFR1+ leukemias

Barnes, E. J., Leonard, J., Medeiros, B. C., Druker, B. J. & Tognon, C. E., Apr 1 2020, In : Cold Spring Harbor Molecular Case Studies. 6, 2

Research output: Contribution to journalArticle

Open Access

Geriatric assessment and treatment outcomes in older adults with cancer receiving immune checkpoint inhibitors

Welaya, K., Loh, K. P., Messing, S., Szuba, E., Magnuson, A., Mohile, S. G. & Maggiore, R. J., Apr 2020, In : Journal of Geriatric Oncology. 11, 3, p. 523-528 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Grading and management of cytokine release syndrome in patients treated with tisagenlecleucel in the JULIET trial

Schuster, S. J., Maziarz, R. T., Rusch, E. S., Li, J., Signorovitch, J. E., Romanov, V. V., Locke, F. L. & Maloney, D. G., Apr 14 2020, In : Blood Advances. 4, 7, p. 1432-1439 8 p.

Research output: Contribution to journalArticle

Open Access

Grading of neurological toxicity in patients treated with tisagenlecleucel in the JULIET trial

Maziarz, R. T., Schuster, S. J., Romanov, V. V., Rusch, E. S., Li, J., Signorovitch, J. E., Maloney, D. G. & Locke, F. L., Apr 14 2020, In : Blood Advances. 4, 7, p. 1440-1447 8 p.

Research output: Contribution to journalArticle

Open Access

Immune checkpoint inhibitors in older adults with melanoma or cutaneous malignancies: The Wilmot Cancer Institute experience

Archibald, W. J., Victor, A. I., Strawderman, M. S. & Maggiore, R. J., Apr 2020, In : Journal of Geriatric Oncology. 11, 3, p. 496-502 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Immune Predictors of Mortality after Ribonucleic Acid Virus Infection

Graham, J. B., Swarts, J. L., Menachery, V. D., Gralinski, L. E., Schäfer, A., Plante, K. S., Morrison, C. R., Voss, K. M., Green, R., Choonoo, G., Jeng, S., Miller, D. R., Mooney, M. A., McWeeney, S. K., Ferris, M. T., De Villena, F. P. M., Gale, M., Heise, M. T., Baric, R. S. & Lund, J. M., Mar 15 2020, In : Journal of Infectious Diseases. 221, 6, p. 882-889 8 p.

Research output: Contribution to journalArticle

Immune Thrombocytopenic Purpura Splenectomy in the Context of New Medical Therapies

Worrest, T., Cunningham, A., Dewey, E., Deloughery, T., Gilbert, E., Sheppard, B. & Fischer, L. E., Jan 1 2020, In : Journal of Surgical Research. 245, p. 643-648 6 p.

Research output: Contribution to journalArticle

Impact of conditioning intensity of allogeneic transplantation for acute myeloid leukemia with genomic evidence of residual disease

Hourigan, C. S., Dillon, L. W., Gui, G., Logan, B. R., Fei, M., Ghannam, J., Li, Y., Licon, A., Alyea, E. P., Bashey, A., Deeg, H. J., Devine, S. M., Fernandez, H. F., Giralt, S., Hamadani, M., Howard, A., Maziarz, R. T., Porter, D. L., Scott, B. L., Warlick, E. D. & 2 others, Pasquini, M. C. & Horwitz, M. E., Apr 20 2020, In : Journal of Clinical Oncology. 38, 12, p. 1273-1283 11 p.

Research output: Contribution to journalArticle

Large epigenome-wide association study of childhood ADHD identifies peripheral DNA methylation associated with disease and polygenic risk burden

Mooney, M. A., Ryabinin, P., Wilmot, B., Bhatt, P., Mill, J. & Nigg, J. T., Dec 1 2020, In : Translational Psychiatry. 10, 1, 8.

Research output: Contribution to journalArticle

Open Access

Linsitinib (OSI-906) for the treatment of adult and pediatric wild-type gastrointestinal stromal tumors, a SARC phase II study

Von Mehren, M., George, S., Heinrich, M. C., Schuetze, S. M., Yap, J. T., Yu, J. Q., Abbott, A., Litwin, S., Crowley, J., Belinsky, M., Janeway, K. A., Hornick, J. L., Flieder, D. B., Chugh, R., Rink, L. & Van Den Abbeele, A. D., Apr 15 2020, In : Clinical Cancer Research. 26, 8, p. 1837-1845 9 p.

Research output: Contribution to journalArticle

Measure Twice: Promise of Liquid Biopsy in Pediatric High-Grade Gliomas

Dietz, M. S., Beach, C. Z., Barajas, R., Parappilly, M. S., Sengupta, S. K., Baird, L. C., Ciporen, J. N., Han, S. J., Loret de Mola, R., Cho, Y. J., Nazemi, K. J., McClelland, S., Wong, M. H. & Jaboin, J. J., Mar 1 2020, In : Advances in Radiation Oncology. 5, 2, p. 152-162 11 p.

Research output: Contribution to journalReview article

Open Access

Medical Reversals in Family Practice: A Review

Haslam, A., Livingston, C. & Prasad, V., 2020, In : Current Therapeutic Research - Clinical and Experimental. 92, 100579.

Research output: Contribution to journalArticle

Open Access

Multi-Institutional Evaluation of Interrater Agreement of Variant Classification Based on the 2017 Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer

Sirohi, D., Schmidt, R. L., Aisner, D. L., Behdad, A., Betz, B. L., Brown, N., Coleman, J. F., Corless, C. L., Deftereos, G., Ewalt, M. D., Fernandes, H., Hsiao, S. J., Mansukhani, M. M., Murray, S. S., Niu, N., Ritterhouse, L. L., Suarez, C. J., Tafe, L. J., Thorson, J. A., Segal, J. P. & 1 others, Furtado, L. V., Feb 2020, In : Journal of Molecular Diagnostics. 22, 2, p. 284-293 10 p.

Research output: Contribution to journalArticle

Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1

Bollu, L. R., Shepherd, J., Zhao, D., Ma, Y., Tahaney, W., Speers, C., Mazumdar, A., Mills, G. B. & Brown, P. H., Dec 1 2020, In : npj Breast Cancer. 6, 1, 2.

Research output: Contribution to journalArticle

Open Access

Nivolumab Monotherapy and Nivolumab Plus Ipilimumab in Recurrent Small Cell Lung Cancer: Results From the CheckMate 032 Randomized Cohort

Ready, N. E., Ott, P. A., Hellmann, M. D., Zugazagoitia, J., Hann, C. L., de Braud, F., Antonia, S. J., Ascierto, P. A., Moreno, V., Atmaca, A., Salvagni, S., Taylor, M., Amin, A., Camidge, D. R., Horn, L., Calvo, E., Li, A., Lin, W. H., Callahan, M. K. & Spigel, D. R., Mar 2020, In : Journal of Thoracic Oncology. 15, 3, p. 426-435 10 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells

Fenerich, B. A., Fernandes, J. C., Rodrigues Alves, A. P. N., Coelho-Silva, J. L., Scopim-Ribeiro, R., Scheucher, P. S., Eide, C. A., Tognon, C. E., Druker, B. J., Rego, E. M., Machado-Neto, J. A. & Traina, F., Dec 1 2020, In : Signal Transduction and Targeted Therapy. 5, 1, 5.

Research output: Contribution to journalArticle

Open Access

NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas—a study of 4569 cases

Chou, A., Fraser, T., Ahadi, M., Fuchs, T., Sioson, L., Clarkson, A., Sheen, A., Singh, N., Corless, C. L. & Gill, A. J., May 1 2020, In : Modern Pathology. 33, 5, p. 924-932 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Oncology Drug Advisory Committee Recommendations and the US Food and Drug Administration's Actions

Haslam, A., Gill, J. & Prasad, V., Feb 2020, In : Mayo Clinic Proceedings. 95, 2, p. 424-426 3 p.

Research output: Contribution to journalLetter

Open Access

Our best weapons against cancer are not magic bullets

Prasad, V., Jan 23 2020, In : Nature. 577, 7791, 1 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Patient Experience Captured by Quality-of-Life Measurement in Oncology Clinical Trials

Haslam, A., Herrera-Perez, D., Gill, J. & Prasad, V., Mar 2 2020, In : JAMA Network Open. 3, 3, p. e200363

Research output: Contribution to journalArticle

Open Access