• 5281 Citations
  • 40 h-Index
1975 …2020
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Research Output 1975 2019

  • 5281 Citations
  • 40 h-Index
  • 109 Article
  • 1 Review article
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Article
2019
1 Citation (Scopus)
Hepcidins
Iron
Hormones
matriptase 2
Liver
2018
1 Citation (Scopus)

The hemochromatosis protein HFE signals predominantly via the BMP type I receptor ALK3 in vivo

Traeger, L., Enns, C., Krijt, J. & Steinbicker, A. U., Dec 1 2018, In : Communications Biology. 1, 1, 65.

Research output: Contribution to journalArticle

Open Access
Type I Bone Morphogenetic Protein Receptors
hemochromatosis
Hepcidins
bone morphogenetic proteins
Iron
5 Citations (Scopus)

Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms

Kleven, M. D., Jue, S. & Enns, C., Mar 6 2018, In : Biochemistry. 57, 9, p. 1552-1559 8 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Hepcidins
Hemochromatosis
Iron

Ultrafiltered recombinant AAV8 vector can be safely administered in vivo and efficiently transduces liver

Kleven, M. D., Gomes, M. M., Wortham, A. M., Enns, C. & Kahl, C., Apr 1 2018, In : PLoS One. 13, 4, e0194728.

Research output: Contribution to journalArticle

Dependovirus
Liver
Viruses
liver
green fluorescent protein
6 Citations (Scopus)

VIPER is a genetically encoded peptide tag for fluorescence and electron microscopy

Doh, J. K., White, J. D., Zane, H. K., Chang, Y. H., Lopez, C., Enns, C. & Beatty, K., Dec 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 51, p. 12961-12966 6 p.

Research output: Contribution to journalArticle

Fluorescence Microscopy
Electron Microscopy
Peptides
Proteins
Technology
2017
24 Citations (Scopus)

Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway

Wahedi, M., Wortham, A. M., Kleven, M. D., Zhao, N., Jue, S., Enns, C. & Zhang, A-S., 2017, In : Journal of Biological Chemistry. 292, 44, p. 18354-18371 18 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Bone Morphogenetic Protein Receptors
Transferrin Receptors
Liver
5 Citations (Scopus)

The tumor suppressor, P53, decreases the metal transporter, ZIP14

Zhao, N., Zhang, A-S., Wortham, A. M., Jue, S., Knutson, M. D. & Enns, C., Dec 8 2017, In : Nutrients. 9, 12, 1335.

Research output: Contribution to journalArticle

transporters
Iron
Metals
metals
iron
7 Citations (Scopus)

Versatile Interacting Peptide (VIP) Tags for Labeling Proteins with Bright Chemical Reporters

Zane, H. K., Doh, J. K., Enns, C. & Beatty, K., Mar 2 2017, In : ChemBioChem. 18, 5, p. 470-474 5 p.

Research output: Contribution to journalArticle

Labeling
Peptides
Fluorophores
Proteins
Quantum Dots
2016
4 Citations (Scopus)

Bone Morphogenetic Protein-6 Mutations Take Their Place in Iron Overload Diseases

Kleven, M. D., Enns, C. & Zhang, A-S., Mar 1 2016, In : Gastroenterology. 150, 3, p. 556-559 4 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 6
Hepcidins
Iron Overload
Hemochromatosis
Missense Mutation
79 Citations (Scopus)

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia

Tuschl, K., Meyer, E., Valdivia, L. E., Zhao, N., Dadswell, C., Abdul-Sada, A., Hung, C. Y., Simpson, M. A., Chong, W. K., Jacques, T. S., Woltjer, R. R., Eaton, S., Gregory, A., Sanford, L., Kara, E., Houlden, H., Cuno, S. M., Prokisch, H., Valletta, L., Tiranti, V. & 20 others, Younis, R., Maher, E. R., Spencer, J., Straatman-Iwanowska, A., Gissen, P., Selim, L. A. M., Pintos-Morell, G., Coroleu-Lletget, W., Mohammad, S. S., Yoganathan, S., Dale, R. C., Thomas, M., Rihel, J., Bodamer, O. A., Enns, C., Hayflick, S., Clayton, P. T., Mills, P. B., Kurian, M. A. & Wilson, S. W., May 27 2016, In : Nature Communications. 7, 11601.

Research output: Contribution to journalArticle

Dystonic Disorders
homeostasis
Parkinsonian Disorders
Manganese
mutations
20 Citations (Scopus)

Neogenin facilitates the induction of hepcidin expression by hemojuvelin in the liver

Zhao, N., Maxson, J., Zhang, R. H., Wahedi, M., Enns, C. & Zhang, A-S., Jun 3 2016, In : Journal of Biological Chemistry. 291, 23, p. 12322-12335 14 p.

Research output: Contribution to journalArticle

Hepcidins
Liver
Bone Morphogenetic Proteins
Furin
Type I Bone Morphogenetic Protein Receptors
2015
11 Citations (Scopus)

CD81 Promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression

Chen, J. & Enns, C., Mar 20 2015, In : Journal of Biological Chemistry. 290, 12, p. 7841-7850 10 p.

Research output: Contribution to journalArticle

Hepcidins
Transferrin Receptors
Maintenance
Degradation
Iron
26 Citations (Scopus)

Low intracellular iron increases the stability of Matriptase-2

Zhao, N., Nizzi, C. P., Anderson, S. A., Wang, J., Ueno, A., Tsukamoto, H., Eisenstein, R. S., Enns, C. & Zhang, A-S., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 4432-4446 15 p.

Research output: Contribution to journalArticle

Iron
Hepcidins
Hepatocytes
Homeostasis
Stabilization
2014
27 Citations (Scopus)
Membrane Transport Proteins
Glycosylation
Iron
Metals
Cell Membrane
31 Citations (Scopus)

The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body

Worthen, C. A. & Enns, C., 2014, In : Frontiers in Pharmacology. 5 MAR, Article 034.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Hepcidins
Homeostasis
Iron
2013
16 Citations (Scopus)

Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo

Byrne, S. L., Buckett, P. D., Kim, J., Luo, F., Sanford, J., Chen, J., Enns, C. & Wessling-Resnick, M., Jul 23 2013, In : PLoS One. 8, 7, e70199.

Research output: Contribution to journalArticle

Transferrin Receptors
transferrin
Degradation
receptors
degradation
37 Citations (Scopus)

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Enns, C., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H. & Zhang, A-S., Apr 2 2013, In : PLoS One. 8, 4, e60534.

Research output: Contribution to journalArticle

Liver
hepatocytes
Hepatocytes
Iron
iron
105 Citations (Scopus)

Iron regulation by hepcidin

Zhao, N., Zhang, A-S. & Enns, C., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2337-2343 7 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Erythropoiesis
Bone Morphogenetic Protein 6
Bone Morphogenetic Protein Receptors
6 Citations (Scopus)
Glycosylation
Transferrin Receptors
Transferrin
Stabilization
Iron
6 Citations (Scopus)

The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization

Wang, J., Chen, J., Enns, C. & Mayinger, P., Aug 1 2013, In : PLoS One. 8, 8, e71112.

Research output: Contribution to journalArticle

lysyllysine
Transferrin Receptors
transferrin
Cell membranes
Starvation
2012
18 Citations (Scopus)

Hereditary hemochromatosis and transferrin receptor 2

Chen, J. & Enns, C., Mar 2012, In : Biochimica et Biophysica Acta - General Subjects. 1820, 3, p. 256-263 8 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Hemochromatosis
Iron
Hepcidins
Homeostasis
16 Citations (Scopus)

Iron Transport Machinery of Human Cells. Players and Their Interactions

Zhao, N. & Enns, C., 2012, In : Current Topics in Membranes. 69, p. 67-93 27 p.

Research output: Contribution to journalArticle

Iron
Mammals
47 Citations (Scopus)

Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage

Enns, C., Ahmed, R. & Zhang, A-S., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35104-35117 14 p.

Research output: Contribution to journalArticle

Oligosaccharides
Cell membranes
matriptase 2
neogenin
Hepatocytes
2011
67 Citations (Scopus)

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

Zhang, A-S., Anderson, S. A., Wang, J., Yang, F., DeMaster, K., Ahmed, R., Nizzi, C. P., Eisenstein, R. S., Tsukamoto, H. & Enns, C., Feb 3 2011, In : Blood. 117, 5, p. 1687-1899 213 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Liver
Rats
Transferrin
2010
52 Citations (Scopus)

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

Gao, J., Chen, J., De Domenico, I., Koeller, D., Harding, C., Fleming, R. E., Koeberl, D. D. & Enns, C., Apr 22 2010, In : Blood. 115, 16, p. 3374-3381 8 p.

Research output: Contribution to journalArticle

Hepcidins
Hepatocytes
Iron
Liver
Genes
47 Citations (Scopus)
Proprotein Convertases
Hepcidins
Bone
Down-Regulation
Bone and Bones
12 Citations (Scopus)

Stoichiometries of transferrin receptors 1 and 2 in human liver

Chloupková, M., Zhang, A-S. & Enns, C., Jan 2010, In : Blood Cells, Molecules, and Diseases. 44, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Liver
Proteins
Iron
Hepcidins
57 Citations (Scopus)

The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo

Zhang, A-S., Gao, J., Koeberl, D. D. & Enns, C., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16416-16423 8 p.

Research output: Contribution to journalArticle

Hepcidins
Hepatocytes
Bone
Bone and Bones
Liver
100 Citations (Scopus)

ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin

Zhao, N., Gao, J., Enns, C. & Knutson, M. D., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32141-32150 10 p.

Research output: Contribution to journalArticle

Transferrin
Iron
Proteins
Hep G2 Cells
HEK293 Cells
2009
59 Citations (Scopus)

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

Zhang, A-S., Yang, F., Wang, J., Tsukamoto, H. & Enns, C., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22580-22589 10 p.

Research output: Contribution to journalArticle

Hepcidins
Bone
Bone and Bones
Proteins
Liver
208 Citations (Scopus)

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A-S. & Enns, C., Mar 4 2009, In : Cell Metabolism. 9, 3, p. 217-227 11 p.

Research output: Contribution to journalArticle

Hepcidins
Transferrin Receptors
Transferrin
Iron
Hep G2 Cells
105 Citations (Scopus)

Iron homeostasis: Recently identified proteins provide insight into novel control mechanisms

Zhang, A-S. & Enns, C., Jan 9 2009, In : Journal of Biological Chemistry. 284, 2, p. 711-715 5 p.

Research output: Contribution to journalArticle

Homeostasis
Iron
Proteins
Superoxides
Biochemical Phenomena
88 Citations (Scopus)
Homeostasis
Iron
Hepcidins
Iron-Regulatory Proteins
Dietary Iron
29 Citations (Scopus)

Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells

Maxson, J., Enns, C. & Zhang, A-S., Feb 19 2009, In : Blood. 113, 8, p. 1786-1793 8 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Cell membranes
Hepcidins
Bone Morphogenetic Proteins
Cell Membrane

Reply

Gao, J., Chen, J., Zhang, A-S. & Enns, C., Sep 2009, In : Gastroenterology. 137, 3, p. 1175 1 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Transferrin-directed internalization and cycling of transferrin receptor 2

Chen, J., Wang, J., Meyers, K. R. & Enns, C., Oct 2009, In : Traffic. 10, 10, p. 1488-1501 14 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Ubiquitination
Degradation
Recycling
2008
32 Citations (Scopus)

Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis

Xiong, S., She, H., Zhang, A-S., Wang, J., Mkrtchyan, H., Dynnyk, A., Gordeuk, V. R., French, S. W., Enns, C. & Tsukamoto, H., Sep 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3

Research output: Contribution to journalArticle

Alcoholic Fatty Liver
Iron
Macrophages
Liver
Kupffer Cells
33 Citations (Scopus)

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane

Zhang, A-S., Yang, F., Meyer, K., Hernandez, C., Chapman-Arvedson, T., Bjorkman, P. J. & Enns, C., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17494-17502 9 p.

Research output: Contribution to journalArticle

Cell membranes
Cell Membrane
Hepcidins
Endocytosis
Hepatocytes
55 Citations (Scopus)

The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 Cells

Gao, J., Zhao, N., Knutson, M. D. & Enns, C., Aug 1 2008, In : Journal of Biological Chemistry. 283, 31, p. 21462-21468 7 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Down-Regulation
Iron
Proteins
Transferrin
2007
91 Citations (Scopus)

Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin

Zhang, A-S., Anderson, S. A., Meyers, K. R., Hernandez, C., Eisenstein, R. S. & Enns, C., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12547-12556 10 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Muscle
Skeletal Muscle
Cells
69 Citations (Scopus)

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions

Chen, J., Chloupková, M., Gao, J., Chapman-Arvedson, T. L. & Enns, C., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 36862-36870 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Cell Communication
Hepatocellular Carcinoma
HLA-B7 Antigen
21 Citations (Scopus)

The cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells

Chen, J. & Enns, C., Mar 2 2007, In : Journal of Biological Chemistry. 282, 9, p. 6201-6209 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Iron
Inborn Genetic Diseases
Iron Overload
72 Citations (Scopus)

Transferrin receptor 2: Evidence for ligand-induced stabilization and redirection to a recycling pathway

Johnson, M. B., Chen, J., Murchison, N., Green, F. A. & Enns, C., Mar 2007, In : Molecular Biology of the Cell. 18, 3, p. 743-754 12 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Ligands
Endosomes
Iron
Mutation
2006

Iron in mammals: Pathophysiological mechanisms of overload and deficiency in relation to disease

Johnson, M. B., Enns, C. & Zhang, A-S., 2006, In : Topics in Current Genetics. 14, p. 155-191 37 p.

Research output: Contribution to journalArticle

Mammals
Iron
Hemochromatosis
Protein Transport
Anemia
12 Citations (Scopus)

Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis

Enns, C., 2006, In : Biological Research. 39, 1, p. 105-111 7 p.

Research output: Contribution to journalArticle

hemochromatosis
homeostasis
Homeostasis
Iron
iron
2005
113 Citations (Scopus)

Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

Zhang, A-S., West, A. P., Wyman, A. E., Bjorkman, P. J. & Enns, C., Oct 7 2005, In : Journal of Biological Chemistry. 280, 40, p. 33885-33894 10 p.

Research output: Contribution to journalArticle

Iron
Kidney
GPI-Linked Proteins
Mutation
Hepcidins
8 Citations (Scopus)

Lipooligosaccharide-independent alteration of cellular homeostasis in Neisseria meningitidis-infected epithelial cells

Bonnah, R., Hoelter, J., Steeghs, L., Enns, C., So, M. & Muckenthaler, M. U., Jun 2005, In : Cellular Microbiology. 7, 6, p. 869-885 17 p.

Research output: Contribution to journalArticle

Neisseria meningitidis
Homeostasis
Epithelial Cells
Iron
Transferrin Receptors
23 Citations (Scopus)

The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells

Carlson, H., Zhang, A-S., Fleming, W. & Enns, C., Mar 15 2005, In : Blood. 105, 6, p. 2564-2570 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Iron
Transferrin
Proteins
Hemochromatosis
39 Citations (Scopus)

The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin

Giannetti, A. M., Halbrooks, P. J., Mason, A. B., Vogt, T. M., Enns, C. & Björkman, P. J., Nov 2005, In : Structure. 13, 11, p. 1613-1623 11 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Carrier Proteins
Iron
Binding Sites
2004
172 Citations (Scopus)

Diferric transferrin regulates transferrin receptor 2 protein stability

Johnson, M. B. & Enns, C., Dec 15 2004, In : Blood. 104, 13, p. 4287-4293 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Protein Stability
Proteins
Iron
Transferrin