• 5412 Citations
  • 40 h-Index
1975 …2019

Research output per year

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Research Output

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Article
2019
1 Scopus citations
2018

The hemochromatosis protein HFE signals predominantly via the BMP type I receptor ALK3 in vivo

Traeger, L., Enns, C., Krijt, J. & Steinbicker, A. U., Dec 1 2018, In : Communications Biology. 1, 1, 65.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms

Kleven, M. D., Jue, S. & Enns, C., Mar 6 2018, In : Biochemistry. 57, 9, p. 1552-1559 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Ultrafiltered recombinant AAV8 vector can be safely administered in vivo and efficiently transduces liver

Kleven, M. D., Gomes, M. M., Wortham, A. M., Enns, C. A. & Kahl, C. A., Apr 2018, In : PloS one. 13, 4, e0194728.

Research output: Contribution to journalArticle

2 Scopus citations

VIPER is a genetically encoded peptide tag for fluorescence and electron microscopy

Doh, J. K., White, J. D., Zane, H. K., Chang, Y. H., López, C. S., Enns, C. A. & Beatty, K. E., Dec 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 51, p. 12961-12966 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway

Wahedi, M., Wortham, A. M., Kleven, M. D., Zhao, N., Jue, S., Enns, C. A. & Zhang, A. S., Nov 3 2017, In : Journal of Biological Chemistry. 292, 44, p. 18354-18371 18 p.

Research output: Contribution to journalArticle

27 Scopus citations

The tumor suppressor, P53, decreases the metal transporter, ZIP14

Zhao, N., Zhang, A. S., Wortham, A. M., Jue, S., Knutson, M. D. & Enns, C. A., Dec 8 2017, In : Nutrients. 9, 12, 1335.

Research output: Contribution to journalArticle

8 Scopus citations

Versatile Interacting Peptide (VIP) Tags for Labeling Proteins with Bright Chemical Reporters

Zane, H. K., Doh, J. K., Enns, C. & Beatty, K., Mar 2 2017, In : ChemBioChem. 18, 5, p. 470-474 5 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Bone Morphogenetic Protein-6 Mutations Take Their Place in Iron Overload Diseases

Kleven, M. D., Enns, C. & Zhang, A-S., Mar 1 2016, In : Gastroenterology. 150, 3, p. 556-559 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia

Tuschl, K., Meyer, E., Valdivia, L. E., Zhao, N., Dadswell, C., Abdul-Sada, A., Hung, C. Y., Simpson, M. A., Chong, W. K., Jacques, T. S., Woltjer, R. L., Eaton, S., Gregory, A., Sanford, L., Kara, E., Houlden, H., Cuno, S. M., Prokisch, H., Valletta, L., Tiranti, V. & 20 others, Younis, R., Maher, E. R., Spencer, J., Straatman-Iwanowska, A., Gissen, P., Selim, L. A. M., Pintos-Morell, G., Coroleu-Lletget, W., Mohammad, S. S., Yoganathan, S., Dale, R. C., Thomas, M., Rihel, J., Bodamer, O. A., Enns, C. A., Hayflick, S. J., Clayton, P. T., Mills, P. B., Kurian, M. A. & Wilson, S. W., May 27 2016, In : Nature communications. 7, 11601.

Research output: Contribution to journalArticle

95 Scopus citations

Neogenin facilitates the induction of hepcidin expression by hemojuvelin in the liver

Zhao, N., Maxson, J., Zhang, R. H., Wahedi, M., Enns, C. & Zhang, A-S., Jun 3 2016, In : Journal of Biological Chemistry. 291, 23, p. 12322-12335 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
2015
11 Scopus citations

Low intracellular iron increases the stability of Matriptase-2

Zhao, N., Nizzi, C. P., Anderson, S. A., Wang, J., Ueno, A., Tsukamoto, H., Eisenstein, R. S., Enns, C. A. & Zhang, A. S., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 4432-4446 15 p.

Research output: Contribution to journalArticle

30 Scopus citations
2014
31 Scopus citations
2013

Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo

Byrne, S. L., Buckett, P. D., Kim, J., Luo, F., Sanford, J., Chen, J., Enns, C. & Wessling-Resnick, M., Jul 23 2013, In : PloS one. 8, 7, e70199.

Research output: Contribution to journalArticle

16 Scopus citations

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Enns, C. A., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H. & Zhang, A. S., Apr 2 2013, In : PloS one. 8, 4, e60534.

Research output: Contribution to journalArticle

38 Scopus citations

Iron regulation by hepcidin

Zhao, N., Zhang, A. S. & Enns, C. A., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2337-2343 7 p.

Research output: Contribution to journalArticle

114 Scopus citations
6 Scopus citations

The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization

Wang, J., Chen, J., Enns, C. A. & Mayinger, P., Aug 1 2013, In : PloS one. 8, 8, e71112.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage

Enns, C. A., Ahmed, R. & Zhang, A. S., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35104-35117 14 p.

Research output: Contribution to journalArticle

48 Scopus citations
2011

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

Zhang, A. S., Anderson, S. A., Wang, J., Yang, F., DeMaster, K., Ahmed, R., Nizzi, C. P., Eisenstein, R. S., Tsukamoto, H. & Enns, C. A., Feb 3 2011, In : Blood. 117, 5, p. 1687-1899 213 p.

Research output: Contribution to journalArticle

70 Scopus citations
2010

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

Gao, J., Chen, J., De Domenico, I., Koeller, D. M., Harding, C. O., Fleming, R. E., Koeberl, D. D. & Enns, C. A., Apr 22 2010, In : Blood. 115, 16, p. 3374-3381 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
48 Scopus citations

Stoichiometries of transferrin receptors 1 and 2 in human liver

Chloupková, M., Zhang, A. S. & Enns, C. A., Jan 1 2010, In : Blood Cells, Molecules, and Diseases. 44, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo

Zhang, A. S., Gao, J., Koeberl, D. D. & Enns, C. A., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16416-16423 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin

Zhao, N., Gao, J., Enns, C. A. & Knutson, M. D., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32141-32150 10 p.

Research output: Contribution to journalArticle

104 Scopus citations
2009

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

Zhang, A. S., Yang, F., Wang, J., Tsukamoto, H. & Enns, C. A., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22580-22589 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A. S. & Enns, C. A., Mar 4 2009, In : Cell Metabolism. 9, 3, p. 217-227 11 p.

Research output: Contribution to journalArticle

210 Scopus citations

Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells

Maxson, J. E., Enns, C. A. & Zhang, A. S., Feb 19 2009, In : Blood. 113, 8, p. 1786-1793 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Transferrin-directed internalization and cycling of transferrin receptor 2

Chen, J., Wang, J., Meyers, K. R. & Enns, C. A., Oct 1 2009, In : Traffic. 10, 10, p. 1488-1501 14 p.

Research output: Contribution to journalArticle

38 Scopus citations
2008

Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis

Xiong, S., She, H., Zhang, A. S., Wang, J., Mkrtchyan, H., Dynnyk, A., Gordeuk, V. R., French, S. W., Enns, C. A. & Tsukamoto, H., Sep 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3, p. G512-G521

Research output: Contribution to journalArticle

32 Scopus citations

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane

Zhang, A. S., Yang, F., Meyer, K., Hernandez, C., Chapman-Arvedson, T., Bjorkman, P. J. & Enns, C. A., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17494-17502 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 Cells

Gao, J., Zhao, N., Knutson, M. D. & Enns, C. A., Aug 1 2008, In : Journal of Biological Chemistry. 283, 31, p. 21462-21468 7 p.

Research output: Contribution to journalArticle

55 Scopus citations
2007

Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin

Zhang, A. S., Anderson, S. A., Meyers, K. R., Hernandez, C., Eisenstein, R. S. & Enns, C. A., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12547-12556 10 p.

Research output: Contribution to journalArticle

92 Scopus citations

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions

Chen, J., Chloupková, M., Gao, J., Chapman-Arvedson, T. L. & Enns, C. A., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 36862-36870 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

The cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells

Chen, J. & Enns, C. A., Mar 2 2007, In : Journal of Biological Chemistry. 282, 9, p. 6201-6209 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Transferrin receptor 2: Evidence for ligand-induced stabilization and redirection to a recycling pathway

Johnson, M. B., Chen, J., Murchison, N., Green, F. A. & Enns, C. A., Mar 2007, In : Molecular biology of the cell. 18, 3, p. 743-754 12 p.

Research output: Contribution to journalArticle

73 Scopus citations
2006
Open Access
12 Scopus citations
2005

Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

Zhang, A. S., West, A. P., Wyman, A. E., Bjorkman, P. J. & Enns, C. A., Oct 7 2005, In : Journal of Biological Chemistry. 280, 40, p. 33885-33894 10 p.

Research output: Contribution to journalArticle

113 Scopus citations

Lipooligosaccharide-independent alteration of cellular homeostasis in Neisseria meningitidis-infected epithelial cells

Bonnah, R. A., Hoelter, J., Steeghs, L., Enns, C. A., So, M. & Muckenthaler, M. U., Jun 1 2005, In : Cellular Microbiology. 7, 6, p. 869-885 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells

Carlson, H., Zhang, A. S., Fleming, W. H. & Enns, C. A., Mar 15 2005, In : Blood. 105, 6, p. 2564-2570 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin

Giannetti, A. M., Halbrooks, P. J., Mason, A. B., Vogt, T. M., Enns, C. A. & Björkman, P. J., Nov 1 2005, In : Structure. 13, 11, p. 1613-1623 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
2004

Diferric transferrin regulates transferrin receptor 2 protein stability

Johnson, M. B. & Enns, C. A., Dec 15 2004, In : Blood. 104, 13, p. 4287-4293 7 p.

Research output: Contribution to journalArticle

174 Scopus citations

Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis

Bonnah, R. A., Muckenthaler, M. U., Carlson, H., Minana, B., Enns, C. A., Hentze, M. W. & So, M., May 1 2004, In : Cellular Microbiology. 6, 5, p. 473-484 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells

Davies, P. S. & Enns, C. A., Jun 11 2004, In : Journal of Biological Chemistry. 279, 24, p. 25085-25092 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

Zhang, A. S., Xiong, S., Tsukamoto, H. & Enns, C. A., Feb 15 2004, In : Blood. 103, 4, p. 1509-1514 6 p.

Research output: Contribution to journalArticle

143 Scopus citations
2003

Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments

Davies, P. S., Zhang, A. S., Anderson, E. L., Roy, C. N., Lampson, M. A., McGraw, T. E. & Enns, C. A., Jul 1 2003, In : Biochemical Journal. 373, 1, p. 145-153 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Heterotypic interactions between transferrin receptor and transferrin receptor 2

Vogt, T. M., Blackwell, A. D., Giannetti, A. M., Bjorkman, P. J. & Enns, C. A., Mar 1 2003, In : Blood. 101, 5, p. 2008-2014 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation

Zhang, A. S., Davies, P. S., Carlson, H. L. & Enns, C. A., Aug 5 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 16, p. 9500-9505 6 p.

Research output: Contribution to journalArticle

36 Scopus citations
2002

Association of human transferrin receptor with GABARAP

Green, F., O'Hare, T., Blackwell, A. & Enns, C. A., May 8 2002, In : FEBS Letters. 518, 1-3, p. 101-106 6 p.

Research output: Contribution to journalArticle

46 Scopus citations