• 5299 Citations
  • 40 h-Index
1975 …2020
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Research Output 1975 2019

  • 5299 Citations
  • 40 h-Index
  • 109 Article
  • 1 Review article
Article
18 Citations (Scopus)

Acquisition of the functional properties of the transferrin receptor during its biosynthesis

Enns, C., Clinton, E. M., Reckhow, C. L., Root, B. J., Do, S. I. & Cook, C., 1991, In : Journal of Biological Chemistry. 266, 20, p. 13272-13277 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Biosynthesis
Transferrin
Disulfides
Cell Surface Receptors
17 Citations (Scopus)

Alteration of epithelial cell transferrin-iron homeostasis by Neisseria meningitidis and Neisseria gonorrhoeae

Bonnah, R., Lee, S. W., Vasquez, B. L., Enns, C. & So, M., 2000, In : Cellular Microbiology. 2, 3, p. 207-218 12 p.

Research output: Contribution to journalArticle

Neisseria meningitidis
Neisseria gonorrhoeae
Transferrin
Homeostasis
Iron
53 Citations (Scopus)
Glycosylation
Transferrin Receptors
Asparagine
Immunoglobulins
Carrier Proteins
27 Citations (Scopus)
Membrane Transport Proteins
Glycosylation
Iron
Metals
Cell Membrane
5 Citations (Scopus)
Transferrin Receptors
K562 Cells
HL-60 Cells
Endocytosis
Dimethyl Sulfoxide
37 Citations (Scopus)
Glycosylation
Transferrin Receptors
Asparagine
Cell Surface Receptors
NIH 3T3 Cells
9 Citations (Scopus)
Cross-Linking Reagents
Aspartic Acid
Catalytic Domain
Enzymes
Cytidine Triphosphate
51 Citations (Scopus)

Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3

Plowman, G. D., Brown, J. P., Enns, C., Schröder, J., Nikinmaa, B., Sussman, H. H., Hellström, K. E. & Hellström, I., 1983, In : Nature. 303, 5912, p. 70-72 3 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 3
Transferrin Receptors
Genes
Fibroblasts
Lymphocytes
44 Citations (Scopus)

Association of human transferrin receptor with GABARAP

Green, F., O'Hare, T., Blackwell, A. & Enns, C., May 8 2002, In : FEBS Letters. 518, 1-3, p. 101-106 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
GABA-A Receptors
Yeast
Assays
Yeasts
45 Citations (Scopus)

Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis

Ramalingam, T. S., West, A. P., Lebrón, J. A., Nangiana, J. S., Hogan, T. H., Enns, C. & Bjorkman, P. J., 2000, In : Nature Cell Biology. 2, 12, p. 953-957 5 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Endocytosis
Homeostasis
Iron
Hemochromatosis
4 Citations (Scopus)

Bone Morphogenetic Protein-6 Mutations Take Their Place in Iron Overload Diseases

Kleven, M. D., Enns, C. & Zhang, A-S., Mar 1 2016, In : Gastroenterology. 150, 3, p. 556-559 4 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 6
Hepcidins
Iron Overload
Hemochromatosis
Missense Mutation
11 Citations (Scopus)

CD81 Promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression

Chen, J. & Enns, C., Mar 20 2015, In : Journal of Biological Chemistry. 290, 12, p. 7841-7850 10 p.

Research output: Contribution to journalArticle

Hepcidins
Transferrin Receptors
Maintenance
Degradation
Iron
28 Citations (Scopus)

Characterization of human foetal intestinal alkaline phosphatase. Comparison with the isoenzymes from the adult intestine and human tumour cell lines

Behrens, C. M., Enns, C. & Sussman, H. H., 1983, In : Biochemical Journal. 211, 3, p. 553-558 6 p.

Research output: Contribution to journalArticle

Tumor Cell Line
Isoenzymes
Intestines
Alkaline Phosphatase
Tumors
2 Citations (Scopus)

Characterization of proteins that associate with an unglycosylated form of the transferrin receptor in A431 cells

Root, B. J., Reckhow, C. L., Clinton, E. M. & Enns, C., 1988, In : Journal of Biological Chemistry. 263, 35, p. 19071-19076 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Proteins
Tunicamycin
Antibodies
Digestion
2 Citations (Scopus)

Characterization of the transferrin-binding protein in a human trophoblast.

Enns, C. & Sussman, H. H., 1981, In : Placenta. Supplement. 3, p. 23-32 10 p.

Research output: Contribution to journalArticle

Transferrin-Binding Proteins
Trophoblasts
Transferrin
Choriocarcinoma
Acrylamide
36 Citations (Scopus)

Characterization of the transferrin receptor in tunicamycin-treated A431 cells

Reckhow, C. L. & Enns, C., 1988, In : Journal of Biological Chemistry. 263, 15, p. 7297-7301 5 p.

Research output: Contribution to journalArticle

Tunicamycin
Transferrin Receptors
Transferrin
Dimers
Cells

Chemical stabilization of conformational states of aspartate transcarbamoylase

Enns, C. & Chan, W. W. C., 1987, In : Methods. 135, p. 569-577 9 p.

Research output: Contribution to journalArticle

Cross-Linking Reagents
Aspartic Acid
Stabilization
Enzymes
Proteins
481 Citations (Scopus)

Chemistry and biology of eukaryotic iron metabolism

Aisen, P., Enns, C. & Wessling-Resnick, M., 2001, In : International Journal of Biochemistry and Cell Biology. 33, 10, p. 940-959 20 p.

Research output: Contribution to journalArticle

Metabolism
Iron
Yeast
Iron Regulatory Protein 2
Iron Regulatory Protein 1
32 Citations (Scopus)

Cleavage of the transferrin receptor is influenced by the composition of the O-linked carbohydrate at position 104

Rutledge, E. A. & Enns, C., Aug 1996, In : Journal of Cellular Physiology. 168, 2, p. 284-293 10 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Carbohydrates
Chemical analysis
N-Acetylneuraminic Acid
Amino Acids
44 Citations (Scopus)

Co-migration and internalization of transferrin and its receptor on K562 cells.

Enns, C., Larrick, J. W., Suomalainen, H., Schroder, J. & Sussman, H. H., Aug 1983, In : Journal of Cell Biology. 97, 2, p. 579-585 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
K562 Cells
Transferrin
Fluorescein-5-isothiocyanate
Antibodies
197 Citations (Scopus)

Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE

West, A. P., Bennett, M. J., Sellers, V. M., Andrews, N. C., Enns, C. & Bjorkman, P. J., Dec 8 2000, In : Journal of Biological Chemistry. 275, 49, p. 38135-38138 4 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Iron
Proteins
Hemochromatosis
19 Citations (Scopus)

Conformational states of aspartate transcarbamoylase stabilized with a cross-linking reagent.

Enns, C. & Chan, W. W., Jul 10 1979, In : Journal of Biological Chemistry. 254, 13, p. 6180-6186 7 p.

Research output: Contribution to journalArticle

Aspartate Carbamoyltransferase
Cross-Linking Reagents
Azides
Aspartic Acid
Escherichia coli
191 Citations (Scopus)

Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation

Gross, C. N., Irrinki, A., Feder, J. N. & Enns, C., Aug 21 1998, In : Journal of Biological Chemistry. 273, 34, p. 22068-22074 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Major Histocompatibility Complex
Iron
Proteins
Transferrin
21 Citations (Scopus)

Cutting edge: Proteasome involvement in the degradation of unassembled Ig light chains

O'Hare, T., Wiens, G. D., Whitcomb, E. A., Enns, C. & Rittenberg, M., Jul 1 1999, In : Journal of Immunology. 163, 1, p. 11-14 4 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Endoplasmic Reticulum
Light
Proteasome Inhibitors
Biosynthetic Pathways
115 Citations (Scopus)

Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway

Liu, G., Thomas, L., Warren, R. A., Enns, C., Cunningham, C. C., Hartwig, J. H. & Thomas, G., Dec 29 1997, In : Journal of Cell Biology. 139, 7, p. 1719-1733 15 p.

Research output: Contribution to journalArticle

Furin
Cytoskeletal Proteins
trans-Golgi Network
Endosomes
Biosynthetic Pathways
172 Citations (Scopus)

Diferric transferrin regulates transferrin receptor 2 protein stability

Johnson, M. B. & Enns, C., Dec 15 2004, In : Blood. 104, 13, p. 4287-4293 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Protein Stability
Proteins
Iron
Transferrin
95 Citations (Scopus)

Distinct saturable pathways for the endocytosis of different tyrosine motifs

Warren, R. A., Green, F. A., Stenberg, P. E. & Enns, C., Jul 3 1998, In : Journal of Biological Chemistry. 273, 27, p. 17056-17063 8 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Endocytosis
Tyrosine
Clathrin
LDL Receptors
52 Citations (Scopus)

Elimination of the O-linked glycosylation site at Thr 104 results in the generation of a soluble human-transferrin receptor

Rutledge, E. A., Root, B. J., Lucas, J. J. & Enns, C., Jan 15 1994, In : Blood. 83, 2, p. 580-586 7 p.

Research output: Contribution to journalArticle

Glycosylation
Transferrin Receptors
Transferrin
Oligosaccharides
Cell membranes

Erratum: Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis (Nature Cell Biology (2000) vol. 2 (953-957))

Ramalingam, T. S., West, A. P., Lebron, J. A., Nangiana, J. S., Hogan, T. H., Enns, C. & Bjorkman, P. J., Jul 1 2003, In : Nature Cell Biology. 5, 7, p. 680 1 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Endocytosis
Cell Biology
Homeostasis
Iron
7 Citations (Scopus)

Evidence for an active dimer of Escherichia coli β galactosidase

Kaneshiro, C. M., Enns, C., Hahn, M. G., Peterson, J. S. & Reithel, F. J., 1975, In : Biochemical Journal. 151, 2, p. 433-434 2 p.

Research output: Contribution to journalArticle

Galactosidases
Escherichia coli K12
Sulfhydryl Compounds
Dimers
Escherichia coli
29 Citations (Scopus)

Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments

Davies, P., Zhang, A-S., Anderson, E. L., Roy, C. N., Lampson, M. A., McGraw, T. E. & Enns, C., Jul 1 2003, In : Biochemical Journal. 373, 1, p. 145-153 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Proteins
Endosomes
Transferrin
Iron
91 Citations (Scopus)

Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin

Zhang, A-S., Anderson, S. A., Meyers, K. R., Hernandez, C., Eisenstein, R. S. & Enns, C., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12547-12556 10 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Muscle
Skeletal Muscle
Cells
23 Citations (Scopus)

Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis

Bonnah, R., Muckenthaler, M. U., Carlson, H., Minana, B., Enns, C., Hentze, M. W. & So, M., May 2004, In : Cellular Microbiology. 6, 5, p. 473-484 12 p.

Research output: Contribution to journalArticle

Neisseria meningitidis
Transferrin Receptors
Iron
Genes
Epithelial Cells
40 Citations (Scopus)

Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells

Davies, P. & Enns, C., Jun 11 2004, In : Journal of Biological Chemistry. 279, 24, p. 25085-25092 8 p.

Research output: Contribution to journalArticle

HT29 Cells
Ferritins
Iron
Proteins
Transferrin Receptors
16 Citations (Scopus)

Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo

Byrne, S. L., Buckett, P. D., Kim, J., Luo, F., Sanford, J., Chen, J., Enns, C. & Wessling-Resnick, M., Jul 23 2013, In : PLoS One. 8, 7, e70199.

Research output: Contribution to journalArticle

Transferrin Receptors
transferrin
Degradation
receptors
degradation
34 Citations (Scopus)

Generation of the soluble transferrin receptor requires cycling through an endosomal compartment

Rutledge, E. A., Green, F. A. & Enns, C., Dec 16 1994, In : Journal of Biological Chemistry. 269, 50, p. 31864-31868 5 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Peptide Hydrolases
Acidification
Cells
Cricetulus
59 Citations (Scopus)

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

Zhang, A-S., Yang, F., Wang, J., Tsukamoto, H. & Enns, C., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22580-22589 10 p.

Research output: Contribution to journalArticle

Hepcidins
Bone
Bone and Bones
Proteins
Liver
32 Citations (Scopus)

Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis

Xiong, S., She, H., Zhang, A-S., Wang, J., Mkrtchyan, H., Dynnyk, A., Gordeuk, V. R., French, S. W., Enns, C. & Tsukamoto, H., Sep 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3

Research output: Contribution to journalArticle

Alcoholic Fatty Liver
Iron
Macrophages
Liver
Kupffer Cells
52 Citations (Scopus)

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

Gao, J., Chen, J., De Domenico, I., Koeller, D., Harding, C., Fleming, R. E., Koeberl, D. D. & Enns, C., Apr 22 2010, In : Blood. 115, 16, p. 3374-3381 8 p.

Research output: Contribution to journalArticle

Hepcidins
Hepatocytes
Iron
Liver
Genes
18 Citations (Scopus)

Hereditary hemochromatosis and transferrin receptor 2

Chen, J. & Enns, C., Mar 2012, In : Biochimica et Biophysica Acta - General Subjects. 1820, 3, p. 256-263 8 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Hemochromatosis
Iron
Hepcidins
Homeostasis
37 Citations (Scopus)

Heterotypic interactions between transferrin receptor and transferrin receptor 2

Vogt, T. M., Blackwell, A. D., Giannetti, A. M., Bjorkman, P. J. & Enns, C., Mar 1 2003, In : Blood. 101, 5, p. 2008-2014 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Iron
Erythroid Cells
Proteins
Hemochromatosis
69 Citations (Scopus)

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions

Chen, J., Chloupková, M., Gao, J., Chapman-Arvedson, T. L. & Enns, C., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 36862-36870 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Cell Communication
Hepatocellular Carcinoma
HLA-B7 Antigen
42 Citations (Scopus)

Human transferrin receptor: Expression of the receptor is assigned to chromosome 3

Enns, C., Suomalainen, H. A., Gebhardt, J. E., Schröder, J. & Sussman, H. H., 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 10 I, p. 3241-3245 5 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Chromosomes, Human, Pair 3
Human Chromosomes
Lymphocytes
Proteins
38 Citations (Scopus)

Human transferrin receptor contains o-linked oligosaccharides

Do, S. I., Enns, C. & Cummings, R. D., Jan 5 1990, In : Journal of Biological Chemistry. 265, 1, p. 114-125 12 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Oligosaccharides
Acetylgalactosamine
K562 Cells
Cells
9 Citations (Scopus)

Hybrid aspartate transcarbamoylase containing cross-linked subunits.

Chan, W. W. & Enns, C., Jun 1981, In : Canadian Journal of Biochemistry. 59, 6, p. 461-468 8 p.

Research output: Contribution to journalArticle

Aspartic Acid
Catalytic Domain
Enzymes
Cytidine Triphosphate
Adenosine Triphosphate
42 Citations (Scopus)

Identification of the O-linked glycosylation site of the human transferrin receptor

Hayes, G. R., Enns, C. & Lucas, J. J., Aug 1992, In : Glycobiology. 2, 4, p. 355-359 5 p.

Research output: Contribution to journalArticle

Glycosylation
Transferrin Receptors
Receptor
Amino acids
Amino Acids
37 Citations (Scopus)

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Enns, C., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H. & Zhang, A-S., Apr 2 2013, In : PLoS One. 8, 4, e60534.

Research output: Contribution to journalArticle

Liver
hepatocytes
Hepatocytes
Iron
iron
31 Citations (Scopus)

Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells

Roy, C. N., Blemings, K. P., Deck, K. M., Davies, P., Anderson, E. L., Eisenstein, R. S. & Enns, C., 2002, In : Journal of Cellular Physiology. 190, 2, p. 218-226 9 p.

Research output: Contribution to journalArticle

Iron-Regulatory Proteins
Iron
RNA
Transferrin Receptors
Chemical activation
113 Citations (Scopus)

Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

Zhang, A-S., West, A. P., Wyman, A. E., Bjorkman, P. J. & Enns, C., Oct 7 2005, In : Journal of Biological Chemistry. 280, 40, p. 33885-33894 10 p.

Research output: Contribution to journalArticle

Iron
Kidney
GPI-Linked Proteins
Mutation
Hepcidins
208 Citations (Scopus)

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A-S. & Enns, C., Mar 4 2009, In : Cell Metabolism. 9, 3, p. 217-227 11 p.

Research output: Contribution to journalArticle

Hepcidins
Transferrin Receptors
Transferrin
Iron
Hep G2 Cells