• 5299 Citations
  • 40 h-Index
1975 …2020
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Research Output 1975 2019

  • 5299 Citations
  • 40 h-Index
  • 109 Article
  • 1 Review article
2004
172 Citations (Scopus)

Diferric transferrin regulates transferrin receptor 2 protein stability

Johnson, M. B. & Enns, C., Dec 15 2004, In : Blood. 104, 13, p. 4287-4293 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Protein Stability
Proteins
Iron
Transferrin
23 Citations (Scopus)

Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis

Bonnah, R., Muckenthaler, M. U., Carlson, H., Minana, B., Enns, C., Hentze, M. W. & So, M., May 2004, In : Cellular Microbiology. 6, 5, p. 473-484 12 p.

Research output: Contribution to journalArticle

Neisseria meningitidis
Transferrin Receptors
Iron
Genes
Epithelial Cells
40 Citations (Scopus)

Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells

Davies, P. & Enns, C., Jun 11 2004, In : Journal of Biological Chemistry. 279, 24, p. 25085-25092 8 p.

Research output: Contribution to journalArticle

HT29 Cells
Ferritins
Iron
Proteins
Transferrin Receptors
142 Citations (Scopus)

Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

Zhang, A-S., Xiong, S., Tsukamoto, H. & Enns, C., Feb 15 2004, In : Blood. 103, 4, p. 1509-1514 6 p.

Research output: Contribution to journalArticle

Metabolism
Liver
Rats
Hepatocytes
Iron
2003

Erratum: Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis (Nature Cell Biology (2000) vol. 2 (953-957))

Ramalingam, T. S., West, A. P., Lebron, J. A., Nangiana, J. S., Hogan, T. H., Enns, C. & Bjorkman, P. J., Jul 1 2003, In : Nature Cell Biology. 5, 7, p. 680 1 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Endocytosis
Cell Biology
Homeostasis
Iron
29 Citations (Scopus)

Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments

Davies, P., Zhang, A-S., Anderson, E. L., Roy, C. N., Lampson, M. A., McGraw, T. E. & Enns, C., Jul 1 2003, In : Biochemical Journal. 373, 1, p. 145-153 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Proteins
Endosomes
Transferrin
Iron
37 Citations (Scopus)

Heterotypic interactions between transferrin receptor and transferrin receptor 2

Vogt, T. M., Blackwell, A. D., Giannetti, A. M., Bjorkman, P. J. & Enns, C., Mar 1 2003, In : Blood. 101, 5, p. 2008-2014 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Iron
Erythroid Cells
Proteins
Hemochromatosis
36 Citations (Scopus)

Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation

Zhang, A-S., Davies, P., Carlson, H. L. & Enns, C., Aug 5 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 16, p. 9500-9505 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Homeostasis
Iron
Mutation
53 Citations (Scopus)

Molecular mechanisms and regulation of iron transport

Chung, J., Wessling-Resnick, M. & Enns, C., 2003, In : Critical Reviews in Clinical Laboratory Sciences. 40, 2, p. 151-182 32 p.

Research output: Contribution to journalArticle

Iron
Tissue
Dietary Iron
Mitochondria
Transferrin
2002
44 Citations (Scopus)

Association of human transferrin receptor with GABARAP

Green, F., O'Hare, T., Blackwell, A. & Enns, C., May 8 2002, In : FEBS Letters. 518, 1-3, p. 101-106 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
GABA-A Receptors
Yeast
Assays
Yeasts
31 Citations (Scopus)

Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells

Roy, C. N., Blemings, K. P., Deck, K. M., Davies, P., Anderson, E. L., Eisenstein, R. S. & Enns, C., 2002, In : Journal of Cellular Physiology. 190, 2, p. 218-226 9 p.

Research output: Contribution to journalArticle

Iron-Regulatory Proteins
Iron
RNA
Transferrin Receptors
Chemical activation
2001
481 Citations (Scopus)

Chemistry and biology of eukaryotic iron metabolism

Aisen, P., Enns, C. & Wessling-Resnick, M., 2001, In : International Journal of Biochemistry and Cell Biology. 33, 10, p. 940-959 20 p.

Research output: Contribution to journalArticle

Metabolism
Iron
Yeast
Iron Regulatory Protein 2
Iron Regulatory Protein 1
3 Citations (Scopus)
Secretory Pathway
Protein Transport
Proteins
40 Citations (Scopus)
Transferrin Receptors
Major Histocompatibility Complex
Hemochromatosis
Iron
Proteins
2000
17 Citations (Scopus)

Alteration of epithelial cell transferrin-iron homeostasis by Neisseria meningitidis and Neisseria gonorrhoeae

Bonnah, R., Lee, S. W., Vasquez, B. L., Enns, C. & So, M., 2000, In : Cellular Microbiology. 2, 3, p. 207-218 12 p.

Research output: Contribution to journalArticle

Neisseria meningitidis
Neisseria gonorrhoeae
Transferrin
Homeostasis
Iron
45 Citations (Scopus)

Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis

Ramalingam, T. S., West, A. P., Lebrón, J. A., Nangiana, J. S., Hogan, T. H., Enns, C. & Bjorkman, P. J., 2000, In : Nature Cell Biology. 2, 12, p. 953-957 5 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Endocytosis
Homeostasis
Iron
Hemochromatosis
197 Citations (Scopus)

Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE

West, A. P., Bennett, M. J., Sellers, V. M., Andrews, N. C., Enns, C. & Bjorkman, P. J., Dec 8 2000, In : Journal of Biological Chemistry. 275, 49, p. 38135-38138 4 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Iron
Proteins
Hemochromatosis
29 Citations (Scopus)

Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells

Roy, C. N., Carlson, E. J., Anderson, E. L., Basava, A., Starnes, S. M., Feder, J. N. & Enns, C., Nov 10 2000, In : FEBS Letters. 484, 3, p. 271-274 4 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Ferritins
Homeostasis
Iron
Mutation
153 Citations (Scopus)

Iron homeostasis: New tales from the crypt

Roy, C. N. & Enns, C., 2000, In : Blood. 96, 13, p. 4020-4027 8 p.

Research output: Contribution to journalArticle

Homeostasis
Iron
Enterocytes
Proteins
Iron-Regulatory Proteins
1999
21 Citations (Scopus)

Cutting edge: Proteasome involvement in the degradation of unassembled Ig light chains

O'Hare, T., Wiens, G. D., Whitcomb, E. A., Enns, C. & Rittenberg, M., Jul 1 1999, In : Journal of Immunology. 163, 1, p. 11-14 4 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Endoplasmic Reticulum
Light
Proteasome Inhibitors
Biosynthetic Pathways
186 Citations (Scopus)

The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

Roy, C. N., Penny, D. M., Feder, J. N. & Enns, C., Mar 26 1999, In : Journal of Biological Chemistry. 274, 13, p. 9022-9028 7 p.

Research output: Contribution to journalArticle

Transferrin
HeLa Cells
Transferrin Receptors
Iron
Proteins
149 Citations (Scopus)

Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cells

Merz, A. J., Enns, C. & So, M., 1999, In : Molecular Microbiology. 32, 6, p. 1316-1332 17 p.

Research output: Contribution to journalArticle

Neisseria
Neisseria gonorrhoeae
Neisseria meningitidis
Epithelial Cells
Membrane Proteins
1998
191 Citations (Scopus)

Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation

Gross, C. N., Irrinki, A., Feder, J. N. & Enns, C., Aug 21 1998, In : Journal of Biological Chemistry. 273, 34, p. 22068-22074 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Major Histocompatibility Complex
Iron
Proteins
Transferrin
95 Citations (Scopus)

Distinct saturable pathways for the endocytosis of different tyrosine motifs

Warren, R. A., Green, F. A., Stenberg, P. E. & Enns, C., Jul 3 1998, In : Journal of Biological Chemistry. 273, 27, p. 17056-17063 8 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Endocytosis
Tyrosine
Clathrin
LDL Receptors
12 Citations (Scopus)

The transferrin receptor cytoplasmic domain determines its rate of transport through the biosynthetic pathway and its susceptibility to cleavage early in the pathway

Rutledge, E. A., Gaston, I., Root, B. J., McGraw, T. E. & Enns, C., May 15 1998, In : Journal of Biological Chemistry. 273, 20, p. 12169-12175 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Biosynthetic Pathways
Biosynthesis
Disulfides
Dimers
1997
115 Citations (Scopus)

Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway

Liu, G., Thomas, L., Warren, R. A., Enns, C., Cunningham, C. C., Hartwig, J. H. & Thomas, G., Dec 29 1997, In : Journal of Cell Biology. 139, 7, p. 1719-1733 15 p.

Research output: Contribution to journalArticle

Furin
Cytoskeletal Proteins
trans-Golgi Network
Endosomes
Biosynthetic Pathways
90 Citations (Scopus)

Saturation of the endocytic pathway for the transferrin receptor does not affect the endocytosis of the epidermal growth factor receptor

Warren, R. A., Green, F. A. & Enns, C., 1997, In : Journal of Biological Chemistry. 272, 4, p. 2116-2121 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Endocytosis
Epidermal Growth Factor Receptor
Vesicular Transport Adaptor Proteins
Clathrin
19 Citations (Scopus)

Structure of human transferrin receptor oligosaccharides: Conservation of site-specific processing

Hayes, G. R., Williams, A. M., Lucas, J. J. & Enns, C., Apr 29 1997, In : Biochemistry. 36, 17, p. 5276-5284 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Oligosaccharides
Conservation
Processing
Glycosylation
112 Citations (Scopus)

The Neisseria type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells

Lin, L., Ayala, P., Larson, J., Mulks, M., Fukuda, M., Carlsson, S. R., Enns, C. & So, M., 1997, In : Molecular Microbiology. 24, 5, p. 1083-1094 12 p.

Research output: Contribution to journalArticle

IgA-specific serine endopeptidase
Neisseria
Epithelial Cells
Bacteria
Survival
1996
32 Citations (Scopus)

Cleavage of the transferrin receptor is influenced by the composition of the O-linked carbohydrate at position 104

Rutledge, E. A. & Enns, C., Aug 1996, In : Journal of Cellular Physiology. 168, 2, p. 284-293 10 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Carbohydrates
Chemical analysis
N-Acetylneuraminic Acid
Amino Acids
19 Citations (Scopus)

The transferrin receptor

Enns, C., Rutledge, E. A. & Williams, A. M., 1996, In : Biomembranes: A Multi-Volume Treatise. 4, C, p. 255-287 33 p.

Research output: Contribution to journalArticle

Transferrin Receptors
1995
23 Citations (Scopus)

The critical glycosylation site of human transferrin receptor contains a high-mannose oligosaccharide

Hayes, G. R., Williams, A., Costello, C. E., Enns, C. & Lucas, J. J., Mar 1995, In : Glycobiology. 5, 2, p. 227-232 6 p.

Research output: Contribution to journalArticle

Glycosylation
Oligosaccharides
Transferrin Receptors
Mannose
Receptor
1994
52 Citations (Scopus)

Elimination of the O-linked glycosylation site at Thr 104 results in the generation of a soluble human-transferrin receptor

Rutledge, E. A., Root, B. J., Lucas, J. J. & Enns, C., Jan 15 1994, In : Blood. 83, 2, p. 580-586 7 p.

Research output: Contribution to journalArticle

Glycosylation
Transferrin Receptors
Transferrin
Oligosaccharides
Cell membranes
34 Citations (Scopus)

Generation of the soluble transferrin receptor requires cycling through an endosomal compartment

Rutledge, E. A., Green, F. A. & Enns, C., Dec 16 1994, In : Journal of Biological Chemistry. 269, 50, p. 31864-31868 5 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Peptide Hydrolases
Acidification
Cells
Cricetulus
1993
37 Citations (Scopus)
Glycosylation
Transferrin Receptors
Asparagine
Cell Surface Receptors
NIH 3T3 Cells
1992
42 Citations (Scopus)

Identification of the O-linked glycosylation site of the human transferrin receptor

Hayes, G. R., Enns, C. & Lucas, J. J., Aug 1992, In : Glycobiology. 2, 4, p. 355-359 5 p.

Research output: Contribution to journalArticle

Glycosylation
Transferrin Receptors
Receptor
Amino acids
Amino Acids
1991
18 Citations (Scopus)

Acquisition of the functional properties of the transferrin receptor during its biosynthesis

Enns, C., Clinton, E. M., Reckhow, C. L., Root, B. J., Do, S. I. & Cook, C., 1991, In : Journal of Biological Chemistry. 266, 20, p. 13272-13277 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Biosynthesis
Transferrin
Disulfides
Cell Surface Receptors
53 Citations (Scopus)
Glycosylation
Transferrin Receptors
Asparagine
Immunoglobulins
Carrier Proteins
1990
5 Citations (Scopus)
Transferrin Receptors
K562 Cells
HL-60 Cells
Endocytosis
Dimethyl Sulfoxide
38 Citations (Scopus)

Human transferrin receptor contains o-linked oligosaccharides

Do, S. I., Enns, C. & Cummings, R. D., Jan 5 1990, In : Journal of Biological Chemistry. 265, 1, p. 114-125 12 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Oligosaccharides
Acetylgalactosamine
K562 Cells
Cells
1988
2 Citations (Scopus)

Characterization of proteins that associate with an unglycosylated form of the transferrin receptor in A431 cells

Root, B. J., Reckhow, C. L., Clinton, E. M. & Enns, C., 1988, In : Journal of Biological Chemistry. 263, 35, p. 19071-19076 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Proteins
Tunicamycin
Antibodies
Digestion
36 Citations (Scopus)

Characterization of the transferrin receptor in tunicamycin-treated A431 cells

Reckhow, C. L. & Enns, C., 1988, In : Journal of Biological Chemistry. 263, 15, p. 7297-7301 5 p.

Research output: Contribution to journalArticle

Tunicamycin
Transferrin Receptors
Transferrin
Dimers
Cells
18 Citations (Scopus)

Modulation of the transferrin receptor during DMSO-induced differentiation in HL-60 cells

Enns, C., Mulkins, M. A., Sussman, H. & Root, B., 1988, In : Experimental Cell Research. 174, 1, p. 89-97 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
HL-60 Cells
Dimethyl Sulfoxide
Cell Differentiation
Cell Proliferation
1987

Chemical stabilization of conformational states of aspartate transcarbamoylase

Enns, C. & Chan, W. W. C., 1987, In : Methods. 135, p. 569-577 9 p.

Research output: Contribution to journalArticle

Cross-Linking Reagents
Aspartic Acid
Stabilization
Enzymes
Proteins
1985
17 Citations (Scopus)

Receptor-mediated endocytosis of human transferrin and its cell surface receptor

Larrick, J. W., Enns, C., Raubitschek, A. & Weintraub, H., 1985, In : Journal of Cellular Physiology. 124, 2, p. 283-287 5 p.

Research output: Contribution to journalArticle

Cell Surface Receptors
Transferrin
Endocytosis
Fluorescein
Transferrin Receptors
1984
6 Citations (Scopus)

Monoclonal antibodies to a purified human transferrin receptor

Nikinmaa, B., Enns, C., Tonik, S. E., Sussman, H. H. & Schröder, J., 1984, In : Scandinavian Journal of Immunology. 20, 5, p. 441-447 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Monoclonal Antibodies
Antibodies
K562 Cells
Transferrin
1983
51 Citations (Scopus)

Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3

Plowman, G. D., Brown, J. P., Enns, C., Schröder, J., Nikinmaa, B., Sussman, H. H., Hellström, K. E. & Hellström, I., 1983, In : Nature. 303, 5912, p. 70-72 3 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 3
Transferrin Receptors
Genes
Fibroblasts
Lymphocytes
28 Citations (Scopus)

Characterization of human foetal intestinal alkaline phosphatase. Comparison with the isoenzymes from the adult intestine and human tumour cell lines

Behrens, C. M., Enns, C. & Sussman, H. H., 1983, In : Biochemical Journal. 211, 3, p. 553-558 6 p.

Research output: Contribution to journalArticle

Tumor Cell Line
Isoenzymes
Intestines
Alkaline Phosphatase
Tumors
44 Citations (Scopus)

Co-migration and internalization of transferrin and its receptor on K562 cells.

Enns, C., Larrick, J. W., Suomalainen, H., Schroder, J. & Sussman, H. H., Aug 1983, In : Journal of Cell Biology. 97, 2, p. 579-585 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
K562 Cells
Transferrin
Fluorescein-5-isothiocyanate
Antibodies
1982
42 Citations (Scopus)

Human transferrin receptor: Expression of the receptor is assigned to chromosome 3

Enns, C., Suomalainen, H. A., Gebhardt, J. E., Schröder, J. & Sussman, H. H., 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 10 I, p. 3241-3245 5 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Chromosomes, Human, Pair 3
Human Chromosomes
Lymphocytes
Proteins