Organization profile

Organization profile

The Department of Physiology & Pharmacology strategically merges systems physiology with chemical biology, spanning from the molecule to the organism. Laboratories within Phys-Pharm carry out cellular and molecular studies, and translate them into the context of whole animal disease models. The department believes that connecting systems-thinking with cutting edge molecular tools will foster exciting science and will be critical to solving the health problems of the 21st century.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Neurons Medicine & Life Sciences
Aromatase Medicine & Life Sciences
Estrogens Medicine & Life Sciences
Brain Medicine & Life Sciences
Solitary Nucleus Medicine & Life Sciences
Baroreflex Medicine & Life Sciences
Hypothalamus Medicine & Life Sciences
Estradiol Medicine & Life Sciences

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Projects 1976 2020

Nervous System
Autonomic Nervous System
Sudden Cardiac Death
Therapeutics
Research

Lipid signaling in cardiovascular afferent transmission

Andresen, M.

National Institutes of Health

8/15/166/30/20

Project: Research projectResearch Project

High Fat Diet
Pressoreceptors
Baroreflex
Glutamic Acid
Lipids

Obesity-induced sympathoexcitation: role of brain insulin

Brooks, V.

National Institutes of Health

1/15/1612/31/19

Project: Research projectResearch Project

Arcuate Nucleus of Hypothalamus
Obesity
Insulin
Angiotensin II
Brain

Research Output 1971 2018

Solitary Nucleus
Brown Adipose Tissue
Thermogenesis
Arterial Pressure
Heart Rate

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Abraham, R., Hauer, D., McPherson, R. L., Utt, A., Kirby, I. T., Cohen, M., Merits, A., Leung, A. K. L. & Griffin, D. E., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. E10457-E10466

Research output: Contribution to journalArticle

Adenosine Diphosphate Ribose
Alphavirus
Hydrolases
Chikungunya virus
Virus Replication
1 Citations

A facile approach for the in vitro assembly of multimeric membrane transport proteins

Riederer, E. A., Focke, P. J., Georgieva, E. R., Akyuz, N., Matulef, K., Borbat, P. P., Freed, J. H., Blanchard, S. C., Boudker, O. & Valiyaveetil, F., Jun 11 2018, In : eLife. 7, e36478.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Spectrum Analysis
Membrane Proteins
Spectroscopy
Antiporters