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2020

A novel class of cardioprotective small-molecule PTP inhibitors

Antonucci, S., Di Sante, M., Sileikyte, J., Deveraux, J., Bauer, T., Bround, M. J., Menabò, R., Paillard, M., Alanova, P., Carraro, M., Ovize, M., Molkentin, J. D., Cohen, M., Forte, M. A., Bernardi, P., Di Lisa, F. & Murphy, E., Jan 2020, In : Pharmacological Research. 151, 104548.

Research output: Contribution to journalArticle

Cardiac sympathetic nerve transdifferentiation reduces action potential heterogeneity after myocardial infarction

Wang, L., Olivas, A., Francis Stuart, S. D., Tapa, S., Blake, M. R., Woodward, W. R., Habecker, B. A. & Ripplinger, C. M., Mar 1 2020, In : American journal of physiology. Heart and circulatory physiology. 318, 3, p. H558-H565

Research output: Contribution to journalArticle

Estradiol Protects Neuropeptide Y/Agouti-Related Peptide Neurons against Insulin Resistance in Females

Qiu, J., Bosch, M. A., Zhang, C., Rønnekleiv, O. K. & Kelly, M. J., Jan 1 2020, In : Neuroendocrinology. 110, 1-2, p. 105-118 14 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

Wang, H., Loerke, D., Bruns, C., Müller, R., Koch, P. A., Puchkov, D., Schultz, C. & Haucke, V., Jan 1 2020, In : Journal of Biological Chemistry. 295, 4, p. 1091-1104 14 p.

Research output: Contribution to journalArticle

2019

5-HT3R–sourced calcium enhances glutamate release from a distinct vesicle pool

Fawley, J. A., Doyle, M. W. & Andresen, M., Oct 15 2019, In : Brain research. 1721, 146346.

Research output: Contribution to journalArticle

1 Scopus citations

A Genetically Encoded Diazirine Analogue for RNA–Protein Photo-crosslinking

Dziuba, D., Hoffmann, J. E., Hentze, M. W. & Schultz, C., Jan 1 2019, (Accepted/In press) In : ChemBioChem.

Research output: Contribution to journalArticle

Open Access

A Shared Mechanism for the Folding of Voltage-Gated K + Channels

McDonald, S. K., Levitz, T. S. & Valiyaveetil, F., Mar 26 2019, In : Biochemistry. 58, 12, p. 1660-1671 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry

Guerra, M., Frey, D., Hagner, M., Dittrich, S., Paulsen, M., Mall, M. A. & Schultz, C., Jan 1 2019, In : ACS Central Science.

Research output: Contribution to journalArticle

3 Scopus citations

Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15

Xie, F., Fan, Q., Li, B. X. & Xiao, X., Jan 1 2019, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Elastase exocytosis by airway neutrophils is associated with early lung damage in children with cystic fibrosis

AREST-CF and IMPEDE-CF, Apr 1 2019, In : American journal of respiratory and critical care medicine. 199, 7, p. 873-881 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

Smilkstein, M. J., Pou, S., Krollenbrock, A., Bleyle, L. A., Dodean, R. A., Frueh, L., Hinrichs, D. J., Li, Y., Martinson, T., Munar, M. Y., Winter, R. W., Bruzual, I., Whiteside, S., Nilsen, A., Koop, D., Kelly, J. X., Kappe, S. H. I., Wilder, B. K. & Riscoe, M., Aug 27 2019, In : Malaria Journal. 18, 1, 291.

Research output: Contribution to journalArticle

Open Access

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

Hirose, K., Payumo, A. Y., Cutie, S., Hoang, A., Zhang, H., Guyot, R., Lunn, D., Bigley, R. B., Yu, H., Wang, J., Smith, M., Gillett, E., Muroy, S. E., Schmid, T., Wilson, E., Field, K. A., Reeder, D. A. M., Maden, M., Yartsev, M. M., Wolfgang, M. J. & 8 others, Grützner, F., Scanlan, T. T., Szweda, L. I., Buffenstein, R., Hu, G., Flamant, F., Olgin, J. E. & Huang, G. N., Jan 1 2019, In : Science. 364, 6436, p. 184-188 5 p.

Research output: Contribution to journalArticle

33 Scopus citations
Open Access

Membrane and nuclear initiated estrogenic regulation of homeostasis

Stincic, T. L., Ronnekleiv, O. & Kelly, M., Jan 1 2019, In : Steroids. 108428.

Research output: Contribution to journalArticle

N- And O-Acetylated 3-Iodothyronamines Have No Metabolic or Thermogenic Effects in Male Mice

Gachkar, S., Oelkrug, R., Herrmann, B., Scanlan, T. S., Sun, Q., Biebermann, H., Hoefig, C. S., Schomburg, L. & Mittag, J., Jan 1 2019, (Accepted/In press) In : European Thyroid Journal.

Research output: Contribution to journalArticle

Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line

Hauke, S., Dutta, A. K., Eisenbeis, V. B., Bezold, D., Bittner, T., Wittwer, C., Thakor, D., Pavlovic, I., Schultz, C. & Jessen, H. J., Jan 1 2019, In : Chemical Science. 10, 9, p. 2687-2692 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Photorelease of 2-Arachidonoylglycerol in Live Cells

Laguerre, A., Hauke, S., Qiu, J., Kelly, M. J. & Schultz, C., Oct 23 2019, In : Journal of the American Chemical Society. 141, 42, p. 16544-16547 4 p.

Research output: Contribution to journalArticle

Prevalence of Cerebrotendinous Xanthomatosis among Patients Diagnosed with Acquired Juvenile-Onset Idiopathic Bilateral Cataracts

Freedman, S. F., Brennand, C., Chiang, J., Debarber, A., Del Monte, M. A., Duell, P. B., Fiorito, J. & Marshall, R., Jan 1 2019, (Accepted/In press) In : JAMA ophthalmology.

Research output: Contribution to journalArticle

Open Access

Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes

Mücksch, F., Citir, M., Lüchtenborg, C., Glass, B., Traynor-Kaplan, A., Schultz, C., Brügger, B. & Kräusslich, H. G., Dec 1 2019, In : Scientific Reports. 9, 1, 17661.

Research output: Contribution to journalArticle

Open Access

Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis

Barahman, M., Zhang, W., Harris, H. Y., Aiyer, A., Kabarriti, R., Kinkhabwala, M., Roy-Chowdhury, N., Beck, A. P., Scanlan, T. T., Roy-Chowdhury, J., Asp, P. & Guha, C., Jan 1 2019, In : Journal of Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations

Resistance to the sympathoexcitatory effects of insulin and leptin in late pregnant rats

Shi, Z., Hansen, K. M., Bullock, K. M., Morofuji, Y., Banks, W. A. & Brooks, V., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

1 Scopus citations

Reversible ADP-ribosylation of RNA

Munnur, D., Bartlett, E., Mikolčević, P., Kirby, I. T., Matthias Rack, J. G., Mikoč, A., Cohen, M. & Ahel, I., Jun 20 2019, In : Nucleic acids research. 47, 11, p. 5658-5669 12 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Šileikytė, J., Devereaux, J., de Jong, J., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M. & Cohen, M. S., Oct 17 2019, In : ChemMedChem. 14, 20, p. 1771-1782 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats

Bayles, R. G., Tran, J., Olivas, A., Woodward, W., Fei, S. S., Gao, L. & Habecker, B., Jun 1 2019, In : PloS one. 14, 6, e0218133.

Research output: Contribution to journalArticle

Open Access

Sex differences in the sympathoexcitatory response to insulin in obese rats: role of neuropeptide Y

Shi, Z., Cassaglia, P. A., Pelletier, N. E. & Brooks, V., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

4 Scopus citations

Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics

Kirby, I. T. & Cohen, M., Jan 1 2019, In : Current Topics in Microbiology and Immunology. 420, p. 211-231 21 p.

Research output: Contribution to journalArticle

5 Scopus citations
1 Scopus citations

Synthesis and Cellular Labeling of Caged Phosphatidylinositol Derivatives

Müller, R., Citir, M., Hauke, S. & Schultz, C., Jan 1 2019, (Accepted/In press) In : Chemistry - A European Journal.

Research output: Contribution to journalArticle

Open Access

TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms

Duvoisin, R., Ren, G., Haley, T. L., Taylor, M. H. & Morgans, C., May 1 2019, In : Investigative ophthalmology & visual science. 60, 6, p. 2330-2335 6 p.

Research output: Contribution to journalArticle

Open Access
2018

A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation

Hoffmann, J. E., Dziuba, D., Stein, F. & Schultz, C., Aug 7 2018, In : Biochemistry. 57, 31, p. 4747-4752 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
7 Scopus citations

Acute hyperalgesia and delayed dry eye after corneal abrasion injury

Hegarty, D. M., Hermes, S. M., Morgan, M. M. & Aicher, S., Jul 1 2018, In : Pain Reports. 3, 4, e664.

Research output: Contribution to journalArticle

3 Scopus citations

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Abraham, R., Hauer, D., McPherson, R. L., Utt, A., Kirby, I. T., Cohen, M., Merits, A., Leung, A. K. L. & Griffin, D. E., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. E10457-E10466

Research output: Contribution to journalArticle

9 Scopus citations

A facile approach for the in vitro assembly of multimeric membrane transport proteins

Riederer, E. A., Focke, P. J., Georgieva, E. R., Akyuz, N., Matulef, K., Borbat, P. P., Freed, J. H., Blanchard, S. C., Boudker, O. & Valiyaveetil, F., Jun 11 2018, In : eLife. 7, e36478.

Research output: Contribution to journalArticle

4 Scopus citations

Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation

Francis Stuart, S. D., Wang, L., Woodard, W. R., Ng, G. A., Habecker, B. & Ripplinger, C. M., Sep 1 2018, In : Journal of Physiology. 596, 17, p. 3977-3991 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks

Li, B. X., Chen, J., Chao, B., Zheng, Y. & Xiao, X., Sep 26 2018, In : ACS Central Science. 4, 9, p. 1201-1210 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins

Li, B. X., Chen, J., Chao, B., David, L. & Xiao, X., May 18 2018, In : ACS Chemical Biology. 13, 5, p. 1380-1387 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity

Kirby, I. T., Kojic, A., Arnold, M. R., Thorsell, A. G., Karlberg, T., Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H. & Cohen, M., Dec 20 2018, In : Cell Chemical Biology. 25, 12, p. 1547-1553.e12

Research output: Contribution to journalArticle

4 Scopus citations

CBP modulates sensitivity to dasatinib in pre-BCRþ acute lymphoblastic leukemia

Duque-Afonso, J., Lin, C. H., Han, K., Morgens, D. W., Jeng, E. E., Weng, Z., Jeong, J., Wong, S. H. K., Zhu, L., Wei, M. C., Chae, H. D., Schrappe, M., Cario, G., Duyster, J., Xiao, X., Sakamoto, K. M., Bassik, M. C. & Cleary, M. L., Nov 15 2018, In : Cancer Research. 78, 22, p. 6497-6508 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cocaine Exposure Modulates Perineuronal Nets and Synaptic Excitability of Fast-Spiking Interneurons in the Medial Prefrontal Cortex

Slaker, M. L., Jorgensen, E. T., Hegarty, D. M., Liu, X., Kong, Y., Zhang, F., Linhardt, R. J., Brown, T. E., Aicher, S. & Sorg, B. A., Sep 1 2018, In : eNeuro. 5, 5

Research output: Contribution to journalArticle

4 Scopus citations

Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)

Carter-O'Connell, I., Vermehren-Schmaedick, A., Jin, H., Morgan, R. K., David, L. & Cohen, M., Oct 19 2018, In : ACS Chemical Biology. 13, 10, p. 2841-2848 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Diagnosis, treatment, and clinical outcomes in 43 cases with cerebrotendinous xanthomatosis

Duell, P., Salen, G., Eichler, F. S., De Barber, A., Connor, S. L., Casaday, L., Jayadev, S., Kisanuki, Y., Lekprasert, P., Malloy, M. J., Ramdhani, R. A., Ziajka, P. E., Quinn, J., Su, K. G., Geller, A. S., Diffenderfer, M. R. & Schaefer, E. J., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Contribution to journalArticle

16 Scopus citations

Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons

Stincic, T. L., Ronnekleiv, O. & Kelly, M., Jan 1 2018, (Accepted/In press) In : Hormones and Behavior.

Research output: Contribution to journalArticle

6 Scopus citations

Early prenatal androgen exposure reduces testes size and sperm concentration in sheep without altering neuroendocrine differentiation and masculine sexual behavior

Scully, C. M., Estill, C. T., Amodei, R., McKune, A., Gribbin, K. P., Meaker, M., Stormshak, F. & Roselli, C., Jan 1 2018, In : Domestic Animal Endocrinology. 62, p. 1-9 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effects of sub-chronic MPTP exposure on behavioral and cognitive performance and the microbiome of wild-type and mGlu8 knockout female and male mice

Torres, E. R. S., Akinyeke, T., Stagaman, K., Duvoisin, R., Meshul, C. K., Sharpton, T. J. & Raber, J., Jul 18 2018, In : Frontiers in Behavioral Neuroscience. 12, 140.

Research output: Contribution to journalArticle

5 Scopus citations

Endogenous Fatty Acids Are Essential Signaling Factors of Pancreatic β-Cells and Insulin Secretion

Hauke, S., Keutler, K., Phapale, P., Yushchenko, D. A. & Schultz, C., Oct 1 2018, In : Diabetes. 67, 10, p. 1986-1998 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice

Stincic, T. L., Grachev, P., Bosch, M. A., Ronnekleiv, O. & Kelly, M., Jul 1 2018, In : eNeuro. 5, 4

Research output: Contribution to journalArticle

4 Scopus citations

Estradiol protects proopiomelanocortin neurons against insulin resistance

Qiu, J., Bosch, M. A., Meza, C., Navarro, U. V., Nestor, C. C., Wagner, E. J., Ronnekleiv, O. & Kelly, M., Feb 1 2018, In : Endocrinology. 159, 2, p. 647-664 18 p.

Research output: Contribution to journalArticle

18 Scopus citations