Research Output 1971 2020

2020

A novel class of cardioprotective small-molecule PTP inhibitors

Antonucci, S., Di Sante, M., Sileikyte, J., Deveraux, J., Bauer, T., Bround, M. J., Menabò, R., Paillard, M., Alanova, P., Carraro, M., Ovize, M., Molkentin, J. D., Cohen, M., Forte, M. A., Bernardi, P., Di Lisa, F. & Murphy, E., Jan 2020, In : Pharmacological Research. 151, 104548.

Research output: Contribution to journalArticle

Permeability
Muscle Cells
Cyclosporine
Reperfusion Injury
Mitochondria

Estradiol Protects Neuropeptide Y/Agouti-Related Peptide Neurons against Insulin Resistance in Females

Qiu, J., Bosch, M. A., Zhang, C., Rønnekleiv, O. K. & Kelly, M. J., Jan 1 2020, In : Neuroendocrinology. 110, 1-2, p. 105-118 14 p.

Research output: Contribution to journalArticle

Neuropeptide Y
KATP Channels
Insulin Resistance
Estradiol
Obesity
2019
1 Citation (Scopus)

5-HT3R–sourced calcium enhances glutamate release from a distinct vesicle pool

Fawley, J. A., Doyle, M. W. & Andresen, M., Oct 15 2019, In : Brain research. 1721, 146346.

Research output: Contribution to journalArticle

Glutamic Acid
Calcium
Calcium Channels
Biguanides
Receptors, Serotonin, 5-HT3

A Genetically Encoded Diazirine Analogue for RNA–Protein Photo-crosslinking

Dziuba, D., Hoffmann, J. E., Hentze, M. W. & Schultz, C., Jan 1 2019, (Accepted/In press) In : ChemBioChem.

Research output: Contribution to journalArticle

Open Access
Diazomethane
Crosslinking
Amino Acids
RNA-Binding Proteins
Iron Regulatory Protein 1

Arcuate Kisspeptin Neurons Coordinate Reproductive Activities with Metabolism

Ronnekleiv, O. K., Qiu, J. & Kelly, M. J., May 23 2019, In : Seminars in Reproductive Medicine. 37, 3, p. 131-140 10 p.

Research output: Contribution to journalReview article

Kisspeptins
Neurons
Gonadotropin-Releasing Hormone
Pro-Opiomelanocortin
Neuropeptide Y
2 Citations (Scopus)

A Shared Mechanism for the Folding of Voltage-Gated K + Channels

McDonald, S. K., Levitz, T. S. & Valiyaveetil, F., Mar 26 2019, In : Biochemistry. 58, 12, p. 1660-1671 12 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Dimers
Assays
Membranes
Lipid Bilayers

A suite of bioassays to evaluate CREB inhibitors

Li, B. X. & Xiao, X., Jan 1 2019, (Accepted/In press) Methods in Enzymology. Academic Press Inc., (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cyclic AMP Response Element-Binding Protein
Bioassay
Biological Assay
Neoplasms
Molecules
2 Citations (Scopus)

Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry

Guerra, M., Frey, D., Hagner, M., Dittrich, S., Paulsen, M., Mall, M. A. & Schultz, C., Jan 1 2019, In : ACS Central Science.

Research output: Contribution to journalArticle

Cathepsin G
Flow cytometry
Microscopic examination
Pulmonary diseases
Confocal microscopy

Correction to: Structural basis for potency and promiscuity in poly(ADP-ribose) polymerase (PARP) and tankyrase inhibitors (Journal of Medicinal Chemistry (2017) 60: 4 (1262-1271) DOI: 10.1021/acs.jmedchem.6b00990)

Thorsell, A. G., Ekblad, T., Karlberg, T., Löw, M., Pinto, A. F., Trésaugues, L., Moche, M., Cohen, M. & Schüler, H., Jun 27 2019, In : Journal of Medicinal Chemistry. 62, 12, 1 p.

Research output: Contribution to journalComment/debate

Tankyrases
Pharmaceutical Chemistry
Inhibitory Concentration 50
Poly(ADP-ribose) Polymerase Inhibitors
niraparib

Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15

Xie, F., Fan, Q., Li, B. X. & Xiao, X., Jan 1 2019, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Genes
Prodrugs
Solubility
Neoplasms
1 Citation (Scopus)

Distinct Calcium Sources Define Compartmentalized Synaptic Signaling Domains

Fawley, J. A. & Andresen, M., Jan 1 2019, (Accepted/In press) In : Neuroscientist.

Research output: Contribution to journalReview article

Calcium
Neurotransmitter Agents
Synaptic Transmission
Nervous System
Neurons
10 Citations (Scopus)

Elastase exocytosis by airway neutrophils is associated with early lung damage in children with cystic fibrosis

AREST-CF and IMPEDE-CF, Apr 1 2019, In : American journal of respiratory and critical care medicine. 199, 7, p. 873-881 9 p.

Research output: Contribution to journalArticle

Pancreatic Elastase
Exocytosis
Cystic Fibrosis
Neutrophils
Lung

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

Smilkstein, M. J., Pou, S., Krollenbrock, A., Bleyle, L. A., Dodean, R. A., Frueh, L., Hinrichs, D. J., Li, Y., Martinson, T., Munar, M. Y., Winter, R. W., Bruzual, I., Whiteside, S., Nilsen, A., Koop, D., Kelly, J. X., Kappe, S. H. I., Wilder, B. K. & Riscoe, M., Aug 27 2019, In : Malaria Journal. 18, 1, 291.

Research output: Contribution to journalArticle

Open Access
Malaria
Prodrugs
Plasmodium yoelii
Pharmacokinetics
Sporozoites
25 Citations (Scopus)

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

Hirose, K., Payumo, A. Y., Cutie, S., Hoang, A., Zhang, H., Guyot, R., Lunn, D., Bigley, R. B., Yu, H., Wang, J., Smith, M., Gillett, E., Muroy, S. E., Schmid, T., Wilson, E., Field, K. A., Reeder, D. A. M., Maden, M., Yartsev, M. M., Wolfgang, M. J. & 8 others, Grützner, F., Scanlan, T. T., Szweda, L. I., Buffenstein, R., Hu, G., Flamant, F., Olgin, J. E. & Huang, G. N., Jan 1 2019, In : Science. 364, 6436, p. 184-188 5 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Cardiac Myocytes
Zebrafish
Phylogeny
Cell Cycle Checkpoints

Identification of lamins as the molecular targets of LBL1 using a clickable photoaffinity probe

Xiao, X. & Li, B. X., Jan 1 2019, Methods in Enzymology. Academic Press Inc., (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Lamins
Molecules
Cells
Lamin Type A
Intermediate Filament Proteins
Open Access
Amino Acid Transport System X-AG
Aspartic Acid
Mutagenesis
Amino Acids
Binding Sites

Membrane and nuclear initiated estrogenic regulation of homeostasis

Stincic, T. L., Ronnekleiv, O. & Kelly, M., Jan 1 2019, In : Steroids. 108428.

Research output: Contribution to journalArticle

Nuclear Envelope
Neurons
Homeostasis
Membranes
Kisspeptins

N- And O-Acetylated 3-Iodothyronamines Have No Metabolic or Thermogenic Effects in Male Mice

Gachkar, S., Oelkrug, R., Herrmann, B., Scanlan, T. S., Sun, Q., Biebermann, H., Hoefig, C. S., Schomburg, L. & Mittag, J., Jan 1 2019, (Accepted/In press) In : European Thyroid Journal.

Research output: Contribution to journalArticle

Body Temperature
Body Composition
Indirect Calorimetry
Injections
Brown Adipose Tissue
14 Citations (Scopus)

Onset of differentiation is post-transcriptionally controlled in adult neural stem cells

Baser, A., Skabkin, M., Kleber, S., Dang, Y., Gülcüler Balta, G. S., Kalamakis, G., Göpferich, M., Ibañez, D. C., Schefzik, R., Lopez, A. S., Bobadilla, E. L., Schultz, C., Fischer, B. & Martin-Villalba, A., Feb 7 2019, In : Nature. 566, 7742, p. 100-104 5 p.

Research output: Contribution to journalLetter

Adult Stem Cells
Neural Stem Cells
Stem Cells
Stem Cell Factor
Proteins
3 Citations (Scopus)

Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line

Hauke, S., Dutta, A. K., Eisenbeis, V. B., Bezold, D., Bittner, T., Wittwer, C., Thakor, D., Pavlovic, I., Schultz, C. & Jessen, H. J., Jan 1 2019, In : Chemical Science. 10, 9, p. 2687-2692 6 p.

Research output: Contribution to journalArticle

Open Access
Diphosphates
Photolysis
Inositol
Isomers
Cells

Photorelease of 2-Arachidonoylglycerol in Live Cells

Laguerre, A., Hauke, S., Qiu, J., Kelly, M. J. & Schultz, C., Oct 23 2019, In : Journal of the American Chemical Society. 141, 42, p. 16544-16547 4 p.

Research output: Contribution to journalArticle

Cell signaling
Proteins
Lipids
Machinery
Calcium

Prevalence of Cerebrotendinous Xanthomatosis among Patients Diagnosed with Acquired Juvenile-Onset Idiopathic Bilateral Cataracts

Freedman, S. F., Brennand, C., Chiang, J., Debarber, A., Del Monte, M. A., Duell, P. B., Fiorito, J. & Marshall, R., Jan 1 2019, (Accepted/In press) In : JAMA ophthalmology.

Research output: Contribution to journalArticle

Open Access
Cerebrotendinous Xanthomatosis
Cataract
Cholestanols
Cholestanol
Urine
Open Access
Stellate Ganglion
Sex Characteristics
Publications
Datasets

Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes

Mücksch, F., Citir, M., Lüchtenborg, C., Glass, B., Traynor-Kaplan, A., Schultz, C., Brügger, B. & Kräusslich, H. G., Dec 1 2019, In : Scientific Reports. 9, 1, 17661.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositols
HIV-1
Cell Membrane
Lipids
gag Gene Products
1 Citation (Scopus)

Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis

Barahman, M., Zhang, W., Harris, H. Y., Aiyer, A., Kabarriti, R., Kinkhabwala, M., Roy-Chowdhury, N., Beck, A. P., Scanlan, T. T., Roy-Chowdhury, J., Asp, P. & Guha, C., Jan 1 2019, In : Journal of Hepatology.

Research output: Contribution to journalArticle

Dyslipidemias
Hepatocytes
Atherosclerosis
Transplantation
Cholesterol
1 Citation (Scopus)

Resistance to the sympathoexcitatory effects of insulin and leptin in late pregnant rats

Shi, Z., Hansen, K. M., Bullock, K. M., Morofuji, Y., Banks, W. A. & Brooks, V., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

Leptin
Insulin
Pregnancy
Brain
Cerebrospinal Fluid
Graves Ophthalmopathy
Graves Disease
5 Citations (Scopus)

Reversible ADP-ribosylation of RNA

Munnur, D., Bartlett, E., Mikolčević, P., Kirby, I. T., Matthias Rack, J. G., Mikoč, A., Cohen, M. & Ahel, I., Jun 20 2019, In : Nucleic acids research. 47, 11, p. 5658-5669 12 p.

Research output: Contribution to journalArticle

Open Access
Adenosine Diphosphate
RNA
ADP-ribosylarginine hydrolase
NAD
ADP Ribose Transferases
2 Citations (Scopus)

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Šileikytė, J., Devereaux, J., de Jong, J., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M. & Cohen, M. S., Oct 17 2019, In : ChemMedChem. 14, 20, p. 1771-1782 12 p.

Research output: Contribution to journalArticle

Plasma stability
Isoxazoles
Triazoles
Click Chemistry
Oxidative stress

Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats

Bayles, R. G., Tran, J., Olivas, A., Woodward, W., Fei, S. S., Gao, L. & Habecker, B., Jun 1 2019, In : PloS one. 14, 6, e0218133.

Research output: Contribution to journalArticle

Open Access
Neurochemistry
Inbred WKY Rats
Gene expression
gender differences
Sex Characteristics
4 Citations (Scopus)

Sex differences in the sympathoexcitatory response to insulin in obese rats: role of neuropeptide Y

Shi, Z., Cassaglia, P. A., Pelletier, N. E. & Brooks, V., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

Neuropeptide Y
Sex Characteristics
Obesity
Insulin
Paraventricular Hypothalamic Nucleus
5 Citations (Scopus)

Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics

Kirby, I. T. & Cohen, M., Jan 1 2019, In : Current Topics in Microbiology and Immunology. 420, p. 211-231 21 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate
Polypharmacology
Poly(ADP-ribose) Polymerases
History
Therapeutics
1 Citation (Scopus)
Heart-Assist Devices
Adrenergic Receptors
Phosphotransferases
Quality of Life
Norepinephrine

Synthesis and Cellular Labeling of Caged Phosphatidylinositol Derivatives

Müller, R., Citir, M., Hauke, S. & Schultz, C., Jan 1 2019, (Accepted/In press) In : Chemistry - A European Journal.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositols
Labeling
Derivatives
Phosphates
Membranes

The Life Science Toolbox Provided by Chemical Biology

Schultz, C., Jan 1 2019, In : Israel Journal of Chemistry.

Research output: Contribution to journalReview article

Switches

TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms

Duvoisin, R., Ren, G., Haley, T. L., Taylor, M. H. & Morgans, C., May 1 2019, In : Investigative ophthalmology & visual science. 60, 6, p. 2330-2335 6 p.

Research output: Contribution to journalArticle

Open Access
Autoantibodies
Melanoma
Ocular Paraneoplastic Syndromes
Serum
Immunotherapy

Understanding diverse TRPV1 signaling – an update [version 1; peer review: 4 approved]

Andresen, M., Jan 1 2019, In : F1000Research. 8, 1978.

Research output: Contribution to journalReview article

Open Access
Peer Review
Sensory Receptor Cells
Neurons
Synaptic Vesicles
Calcium Channels

Visualization of intracellular hydrogen peroxide with the genetically encoded fluorescent probe HyPer in NIH-3T3 cells

Ermakova, Y. G., Mishina, N. M., Schultz, C. & Belousov, V. V., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 259-274 16 p. (Methods in Molecular Biology; vol. 1982).

Research output: Chapter in Book/Report/Conference proceedingChapter

NIH 3T3 Cells
Fluorescent Dyes
Hydrogen Peroxide
Reactive Oxygen Species
D-Amino-Acid Oxidase
2018
4 Citations (Scopus)

A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation

Hoffmann, J. E., Dziuba, D., Stein, F. & Schultz, C., Aug 7 2018, In : Biochemistry. 57, 31, p. 4747-4752 6 p.

Research output: Contribution to journalArticle

Proteome
Amino Acids
Proteins
Labeling
Click Chemistry
7 Citations (Scopus)
Solitary Nucleus
Brown Adipose Tissue
Thermogenesis
Arterial Pressure
Heart Rate
3 Citations (Scopus)

Acute hyperalgesia and delayed dry eye after corneal abrasion injury

Hegarty, D. M., Hermes, S. M., Morgan, M. M. & Aicher, S., Jul 1 2018, In : Pain Reports. 3, 4, e664.

Research output: Contribution to journalArticle

Hyperalgesia
Calcitonin Gene-Related Peptide
Pain
Wounds and Injuries
Blinking
8 Citations (Scopus)

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Abraham, R., Hauer, D., McPherson, R. L., Utt, A., Kirby, I. T., Cohen, M., Merits, A., Leung, A. K. L. & Griffin, D. E., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. E10457-E10466

Research output: Contribution to journalArticle

Adenosine Diphosphate Ribose
Alphavirus
Hydrolases
Chikungunya virus
Virus Replication
3 Citations (Scopus)

A facile approach for the in vitro assembly of multimeric membrane transport proteins

Riederer, E. A., Focke, P. J., Georgieva, E. R., Akyuz, N., Matulef, K., Borbat, P. P., Freed, J. H., Blanchard, S. C., Boudker, O. & Valiyaveetil, F., Jun 11 2018, In : eLife. 7, e36478.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Spectrum Analysis
Membrane Proteins
Spectroscopy
Antiporters
8 Citations (Scopus)

Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation

Francis Stuart, S. D., Wang, L., Woodard, W. R., Ng, G. A., Habecker, B. & Ripplinger, C. M., Sep 1 2018, In : Journal of Physiology. 596, 17, p. 3977-3991 15 p.

Research output: Contribution to journalArticle

Cardiac Electrophysiology
Adrenergic Agents
Calcium
Norepinephrine
Heart Rate
5 Citations (Scopus)

A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks

Li, B. X., Chen, J., Chao, B., Zheng, Y. & Xiao, X., Sep 26 2018, In : ACS Central Science. 4, 9, p. 1201-1210 10 p.

Research output: Contribution to journalArticle

Lamins
DNA
Repair
Ligands
Proteins
5 Citations (Scopus)

Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins

Li, B. X., Chen, J., Chao, B., David, L. & Xiao, X., May 18 2018, In : ACS Chemical Biology. 13, 5, p. 1380-1387 8 p.

Research output: Contribution to journalArticle

Lamins
Intermediate Filament Proteins
Lamin Type A
Cytoskeletal Proteins
Actin Cytoskeleton
4 Citations (Scopus)

A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity

Kirby, I. T., Kojic, A., Arnold, M. R., Thorsell, A. G., Karlberg, T., Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H. & Cohen, M., Dec 20 2018, In : Cell Chemical Biology. 25, 12, p. 1547-1553.e12

Research output: Contribution to journalArticle

Adenosine Diphosphate
Catalyst activity
Nuclear Envelope
Poly(ADP-ribose) Polymerases
Availability
1 Citation (Scopus)

A simple, sensitive, and generalizable plate assay for screening PARP inhibitors

Kirby, I. T., Morgan, R. K. & Cohen, M., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 245-252 8 p. (Methods in Molecular Biology; vol. 1813).

Research output: Chapter in Book/Report/Conference proceedingChapter

Enzymes
ADP Ribose Transferases
Unfolded Protein Response
Poly(ADP-ribose) Polymerases
Post Translational Protein Processing
Maternal Exposure
Cardiac Myocytes
Testosterone
Fetus
Pregnancy
1 Citation (Scopus)

CBP modulates sensitivity to dasatinib in pre-BCRþ acute lymphoblastic leukemia

Duque-Afonso, J., Lin, C. H., Han, K., Morgens, D. W., Jeng, E. E., Weng, Z., Jeong, J., Wong, S. H. K., Zhu, L., Wei, M. C., Chae, H. D., Schrappe, M., Cario, G., Duyster, J., Xiao, X., Sakamoto, K. M., Bassik, M. C. & Cleary, M. L., Nov 15 2018, In : Cancer Research. 78, 22, p. 6497-6508 12 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapeutics
Catenins
Dasatinib
Protein-Tyrosine Kinases