Research Output 1971 2019

2019

5-HT3R–sourced calcium enhances glutamate release from a distinct vesicle pool

Fawley, J. A., Doyle, M. W. & Andresen, M., Oct 15 2019, In : Brain research. 1721, 146346.

Research output: Contribution to journalArticle

Glutamic Acid
Calcium
Calcium Channels
Biguanides
Receptors, Serotonin, 5-HT3

A Shared Mechanism for the Folding of Voltage-Gated K + Channels

McDonald, S. K., Levitz, T. S. & Valiyaveetil, F., Mar 26 2019, In : Biochemistry. 58, 12, p. 1660-1671 12 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Dimers
Assays
Membranes
Lipid Bilayers

Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry

Guerra, M., Frey, D., Hagner, M., Dittrich, S., Paulsen, M., Mall, M. A. & Schultz, C., Jan 1 2019, In : ACS Central Science.

Research output: Contribution to journalArticle

Cathepsin G
Flow cytometry
Microscopic examination
Pulmonary diseases
Confocal microscopy

Correction to: Structural basis for potency and promiscuity in poly(ADP-ribose) polymerase (PARP) and tankyrase inhibitors (Journal of Medicinal Chemistry (2017) 60: 4 (1262-1271) DOI: 10.1021/acs.jmedchem.6b00990)

Thorsell, A. G., Ekblad, T., Karlberg, T., Löw, M., Pinto, A. F., Trésaugues, L., Moche, M., Cohen, M. & Schüler, H., Jun 27 2019, In : Journal of Medicinal Chemistry. 62, 12, 1 p.

Research output: Contribution to journalComment/debate

Tankyrases
Pharmaceutical Chemistry
Inhibitory Concentration 50
Poly(ADP-ribose) Polymerase Inhibitors
niraparib

Distinct Calcium Sources Define Compartmentalized Synaptic Signaling Domains

Fawley, J. A. & Andresen, M., Jan 1 2019, (Accepted/In press) In : Neuroscientist.

Research output: Contribution to journalReview article

Calcium
Neurotransmitter Agents
Synaptic Transmission
Nervous System
Neurons
5 Citations (Scopus)

Elastase exocytosis by airway neutrophils is associated with early lung damage in children with cystic fibrosis

AREST-CF and IMPEDE-CF, Apr 1 2019, In : American journal of respiratory and critical care medicine. 199, 7, p. 873-881 9 p.

Research output: Contribution to journalArticle

Pancreatic Elastase
Exocytosis
Cystic Fibrosis
Neutrophils
Lung
9 Citations (Scopus)

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

Hirose, K., Payumo, A. Y., Cutie, S., Hoang, A., Zhang, H., Guyot, R., Lunn, D., Bigley, R. B., Yu, H., Wang, J., Smith, M., Gillett, E., Muroy, S. E., Schmid, T., Wilson, E., Field, K. A., Reeder, D. A. M., Maden, M., Yartsev, M. M., Wolfgang, M. J. & 8 others, Grützner, F., Scanlan, T. T., Szweda, L. I., Buffenstein, R., Hu, G., Flamant, F., Olgin, J. E. & Huang, G. N., Jan 1 2019, In : Science. 364, 6436, p. 184-188 5 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Cardiac Myocytes
Zebrafish
Phylogeny
Cell Cycle Checkpoints

Identification of lamins as the molecular targets of LBL1 using a clickable photoaffinity probe

Xiao, X. & Li, B. X., Jan 1 2019, Methods in Enzymology. Academic Press Inc., (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Lamins
Molecules
Cells
Lamin Type A
Intermediate Filament Proteins
Open Access
Amino Acid Transport System X-AG
Aspartic Acid
Mutagenesis
Amino Acids
Binding Sites

Membrane and nuclear initiated estrogenic regulation of homeostasis

Stincic, T. L., Ronnekleiv, O. & Kelly, M., Jan 1 2019, In : Steroids. 108428.

Research output: Contribution to journalArticle

Nuclear Envelope
Neurons
Homeostasis
Membranes
Kisspeptins
7 Citations (Scopus)

Onset of differentiation is post-transcriptionally controlled in adult neural stem cells

Baser, A., Skabkin, M., Kleber, S., Dang, Y., Gülcüler Balta, G. S., Kalamakis, G., Göpferich, M., Ibañez, D. C., Schefzik, R., Lopez, A. S., Bobadilla, E. L., Schultz, C., Fischer, B. & Martin-Villalba, A., Feb 7 2019, In : Nature. 566, 7742, p. 100-104 5 p.

Research output: Contribution to journalLetter

Adult Stem Cells
Neural Stem Cells
Stem Cells
Stem Cell Factor
Proteins
1 Citation (Scopus)

Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line

Hauke, S., Dutta, A. K., Eisenbeis, V. B., Bezold, D., Bittner, T., Wittwer, C., Thakor, D., Pavlovic, I., Schultz, C. & Jessen, H. J., Jan 1 2019, In : Chemical Science. 10, 9, p. 2687-2692 6 p.

Research output: Contribution to journalArticle

Open Access
Diphosphates
Photolysis
Inositol
Isomers
Cells
Open Access
Stellate Ganglion
Sex Characteristics
Publications
Datasets
1 Citation (Scopus)

Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis

Barahman, M., Zhang, W., Harris, H. Y., Aiyer, A., Kabarriti, R., Kinkhabwala, M., Roy-Chowdhury, N., Beck, A. P., Scanlan, T. T., Roy-Chowdhury, J., Asp, P. & Guha, C., Jan 1 2019, In : Journal of Hepatology.

Research output: Contribution to journalArticle

Dyslipidemias
Hepatocytes
Atherosclerosis
Transplantation
Cholesterol

Resistance to the sympathoexcitatory effects of insulin and leptin in late pregnant rats

Shi, Z., Hansen, K. M., Bullock, K. M., Morofuji, Y., Banks, W. A. & Brooks, V., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

Leptin
Insulin
Pregnancy
Brain
Cerebrospinal Fluid
Graves Ophthalmopathy
Graves Disease
1 Citation (Scopus)

Reversible ADP-ribosylation of RNA

Munnur, D., Bartlett, E., Mikolčević, P., Kirby, I. T., Matthias Rack, J. G., Mikoč, A., Cohen, M. & Ahel, I., Jun 20 2019, In : Nucleic acids research. 47, 11, p. 5658-5669 12 p.

Research output: Contribution to journalArticle

Open Access
Adenosine Diphosphate
RNA
ADP-ribosylarginine hydrolase
NAD
ADP Ribose Transferases

Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats

Bayles, R. G., Tran, J., Olivas, A., Woodward, W., Fei, S. S., Gao, L. & Habecker, B., Jun 1 2019, In : PloS one. 14, 6, e0218133.

Research output: Contribution to journalArticle

Open Access
Neurochemistry
Inbred WKY Rats
Gene expression
gender differences
Sex Characteristics
2 Citations (Scopus)

Sex differences in the sympathoexcitatory response to insulin in obese rats: role of neuropeptide Y

Shi, Z., Cassaglia, P. A., Pelletier, N. E. & Brooks, V., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

Neuropeptide Y
Sex Characteristics
Obesity
Insulin
Paraventricular Hypothalamic Nucleus
4 Citations (Scopus)

Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics

Kirby, I. T. & Cohen, M., Jan 1 2019, In : Current Topics in Microbiology and Immunology. 420, p. 211-231 21 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate
Polypharmacology
Poly(ADP-ribose) Polymerases
History
Therapeutics
Heart-Assist Devices
Adrenergic Receptors
Phosphotransferases
Quality of Life
Norepinephrine

The Life Science Toolbox Provided by Chemical Biology

Schultz, C., Jan 1 2019, In : Israel Journal of Chemistry.

Research output: Contribution to journalReview article

Switches

TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms

Duvoisin, R., Ren, G., Haley, T. L., Taylor, M. H. & Morgans, C., May 1 2019, In : Investigative ophthalmology & visual science. 60, 6, p. 2330-2335 6 p.

Research output: Contribution to journalArticle

Open Access
Autoantibodies
Melanoma
Ocular Paraneoplastic Syndromes
Serum
Immunotherapy

Visualization of intracellular hydrogen peroxide with the genetically encoded fluorescent probe HyPer in NIH-3T3 cells

Ermakova, Y. G., Mishina, N. M., Schultz, C. & Belousov, V. V., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 259-274 16 p. (Methods in Molecular Biology; vol. 1982).

Research output: Chapter in Book/Report/Conference proceedingChapter

NIH 3T3 Cells
Fluorescent Dyes
Hydrogen Peroxide
Reactive Oxygen Species
D-Amino-Acid Oxidase
2018
3 Citations (Scopus)

A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation

Hoffmann, J. E., Dziuba, D., Stein, F. & Schultz, C., Aug 7 2018, In : Biochemistry. 57, 31, p. 4747-4752 6 p.

Research output: Contribution to journalArticle

Proteome
Amino Acids
Proteins
Labeling
Click Chemistry
6 Citations (Scopus)
Solitary Nucleus
Brown Adipose Tissue
Thermogenesis
Arterial Pressure
Heart Rate
2 Citations (Scopus)

Acute hyperalgesia and delayed dry eye after corneal abrasion injury

Hegarty, D. M., Hermes, S. M., Morgan, M. M. & Aicher, S., Jul 1 2018, In : Pain Reports. 3, 4, e664.

Research output: Contribution to journalArticle

Hyperalgesia
Calcitonin Gene-Related Peptide
Pain
Wounds and Injuries
Blinking
5 Citations (Scopus)

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Abraham, R., Hauer, D., McPherson, R. L., Utt, A., Kirby, I. T., Cohen, M., Merits, A., Leung, A. K. L. & Griffin, D. E., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. E10457-E10466

Research output: Contribution to journalArticle

Adenosine Diphosphate Ribose
Alphavirus
Hydrolases
Chikungunya virus
Virus Replication
2 Citations (Scopus)

A facile approach for the in vitro assembly of multimeric membrane transport proteins

Riederer, E. A., Focke, P. J., Georgieva, E. R., Akyuz, N., Matulef, K., Borbat, P. P., Freed, J. H., Blanchard, S. C., Boudker, O. & Valiyaveetil, F., Jun 11 2018, In : eLife. 7, e36478.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Spectrum Analysis
Membrane Proteins
Spectroscopy
Antiporters
6 Citations (Scopus)

Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation

Francis Stuart, S. D., Wang, L., Woodard, W. R., Ng, G. A., Habecker, B. & Ripplinger, C. M., Sep 1 2018, In : Journal of Physiology. 596, 17, p. 3977-3991 15 p.

Research output: Contribution to journalArticle

Cardiac Electrophysiology
Adrenergic Agents
Calcium
Norepinephrine
Heart Rate
3 Citations (Scopus)

A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks

Li, B. X., Chen, J., Chao, B., Zheng, Y. & Xiao, X., Sep 26 2018, In : ACS Central Science. 4, 9, p. 1201-1210 10 p.

Research output: Contribution to journalArticle

Lamins
DNA
Repair
Ligands
Proteins
4 Citations (Scopus)

Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins

Li, B. X., Chen, J., Chao, B., David, L. & Xiao, X., May 18 2018, In : ACS Chemical Biology. 13, 5, p. 1380-1387 8 p.

Research output: Contribution to journalArticle

Lamins
Intermediate Filament Proteins
Lamin Type A
Cytoskeletal Proteins
Actin Cytoskeleton
3 Citations (Scopus)

A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity

Kirby, I. T., Kojic, A., Arnold, M. R., Thorsell, A. G., Karlberg, T., Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H. & Cohen, M., Dec 20 2018, In : Cell Chemical Biology. 25, 12, p. 1547-1553.e12

Research output: Contribution to journalArticle

Adenosine Diphosphate
Catalyst activity
Nuclear Envelope
Poly(ADP-ribose) Polymerases
Availability
1 Citation (Scopus)

A simple, sensitive, and generalizable plate assay for screening PARP inhibitors

Kirby, I. T., Morgan, R. K. & Cohen, M., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 245-252 8 p. (Methods in Molecular Biology; vol. 1813).

Research output: Chapter in Book/Report/Conference proceedingChapter

Enzymes
ADP Ribose Transferases
Unfolded Protein Response
Poly(ADP-ribose) Polymerases
Post Translational Protein Processing
Maternal Exposure
Cardiac Myocytes
Testosterone
Fetus
Pregnancy
1 Citation (Scopus)

CBP modulates sensitivity to dasatinib in pre-BCRþ acute lymphoblastic leukemia

Duque-Afonso, J., Lin, C. H., Han, K., Morgens, D. W., Jeng, E. E., Weng, Z., Jeong, J., Wong, S. H. K., Zhu, L., Wei, M. C., Chae, H. D., Schrappe, M., Cario, G., Duyster, J., Xiao, X., Sakamoto, K. M., Bassik, M. C. & Cleary, M. L., Nov 15 2018, In : Cancer Research. 78, 22, p. 6497-6508 12 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapeutics
Catenins
Dasatinib
Protein-Tyrosine Kinases
2 Citations (Scopus)

Cocaine Exposure Modulates Perineuronal Nets and Synaptic Excitability of Fast-Spiking Interneurons in the Medial Prefrontal Cortex

Slaker, M. L., Jorgensen, E. T., Hegarty, D. M., Liu, X., Kong, Y., Zhang, F., Linhardt, R. J., Brown, T. E., Aicher, S. & Sorg, B. A., Sep 1 2018, In : eNeuro. 5, 5

Research output: Contribution to journalArticle

Interneurons
Prefrontal Cortex
Cocaine
Parvalbumins
Pyramidal Cells
2 Citations (Scopus)

Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)

Carter-O'Connell, I., Vermehren-Schmaedick, A., Jin, H., Morgan, R. K., David, L. & Cohen, M., Oct 19 2018, In : ACS Chemical Biology. 13, 10, p. 2841-2848 8 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Labeling
Adenosine Diphosphate
NAD
Proteins
7 Citations (Scopus)

Diagnosis, treatment, and clinical outcomes in 43 cases with cerebrotendinous xanthomatosis

Duell, P., Salen, G., Eichler, F. S., De Barber, A., Connor, S. L., Casaday, L., Jayadev, S., Kisanuki, Y., Lekprasert, P., Malloy, M. J., Ramdhani, R. A., Ziajka, P. E., Quinn, J., Su, K. G., Geller, A. S., Diffenderfer, M. R. & Schaefer, E. J., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Contribution to journalArticle

Cerebrotendinous Xanthomatosis
Chenodeoxycholic Acid
Cholestanol
Xanthomatosis
Tendons
4 Citations (Scopus)

Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons

Stincic, T. L., Ronnekleiv, O. & Kelly, M., Jan 1 2018, (Accepted/In press) In : Hormones and Behavior.

Research output: Contribution to journalArticle

Estradiol
Neurons
Pro-Opiomelanocortin
Neuropeptide Y
Membranes
1 Citation (Scopus)

Drugging homologous recombination: Back to the future

Sanford-Crane, H., Pejovic, T. & Xiao, X., Jun 1 2018, In : Future Medicinal Chemistry. 10, 11, p. 1279-1281 3 p.

Research output: Contribution to journalReview article

Homologous Recombination
1 Citation (Scopus)

Early prenatal androgen exposure reduces testes size and sperm concentration in sheep without altering neuroendocrine differentiation and masculine sexual behavior

Scully, C. M., Estill, C. T., Amodei, R., McKune, A., Gribbin, K. P., Meaker, M., Stormshak, F. & Roselli, C., Jan 1 2018, In : Domestic Animal Endocrinology. 62, p. 1-9 9 p.

Research output: Contribution to journalArticle

sperm concentration
sexual behavior
Spermatogenesis
First Pregnancy Trimester
androgens
2 Citations (Scopus)

Effects of sub-chronic MPTP exposure on behavioral and cognitive performance and the microbiome of wild-type and mGlu8 knockout female and male mice

Torres, E. R. S., Akinyeke, T., Stagaman, K., Duvoisin, R., Meshul, C. K., Sharpton, T. J. & Raber, J., Jul 18 2018, In : Frontiers in Behavioral Neuroscience. 12, 140.

Research output: Contribution to journalArticle

Microbiota
Parkinson Disease
Metabotropic Glutamate Receptors
Knockout Mice
Fear
6 Citations (Scopus)

Endogenous Fatty Acids Are Essential Signaling Factors of Pancreatic β-Cells and Insulin Secretion

Hauke, S., Keutler, K., Phapale, P., Yushchenko, D. A. & Schultz, C., Oct 1 2018, In : Diabetes. 67, 10, p. 1986-1998 13 p.

Research output: Contribution to journalArticle

Essential Fatty Acids
Fatty Acids
Insulin
G-Protein-Coupled Receptors
Glucose
3 Citations (Scopus)

Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice

Stincic, T. L., Grachev, P., Bosch, M. A., Ronnekleiv, O. & Kelly, M., Jul 1 2018, In : eNeuro. 5, 4

Research output: Contribution to journalArticle

Pro-Opiomelanocortin
Estradiol
Neuropeptide Y
Neurons
Peptides
13 Citations (Scopus)

Estradiol protects proopiomelanocortin neurons against insulin resistance

Qiu, J., Bosch, M. A., Meza, C., Navarro, U. V., Nestor, C. C., Wagner, E. J., Ronnekleiv, O. & Kelly, M., Feb 1 2018, In : Endocrinology. 159, 2, p. 647-664 18 p.

Research output: Contribution to journalArticle

Pro-Opiomelanocortin
Insulin Resistance
Estradiol
Neurons
Diet
7 Citations (Scopus)

Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females

Qiu, J., Rivera, H. M., Bosch, M. A., Padilla, S. L., Stincic, T. L., Palmiter, R. D., Kelly, M. & Ronnekleiv, O., Aug 6 2018, In : eLife. 7, e35656.

Research output: Contribution to journalArticle

Kisspeptins
Synaptic Transmission
Neurons
Pro-Opiomelanocortin
Networks (circuits)

Flow Cytometry Analysis of Free Intracellular NAD+ Using a Targeted Biosensor

Eller, J. M., Stewart, M. L., Slepian, A. J., Markwardt, S., Wiedrick, J., Cohen, M., Goodman, R. & Cambronne, X., Jan 1 2018, (Accepted/In press) In : Current Protocols in Cytometry. e54.

Research output: Contribution to journalArticle

Flow cytometry
Biosensing Techniques
Biosensors
NAD
Flow Cytometry

Hypothalamic-Pituitary-Thyroid Axis Perturbations in Male Mice by CNS-Penetrating Thyromimetics

Ferrara, S. J., Bourdette, D. & Scanlan, T. T., Jul 1 2018, In : Endocrinology. 159, 7, p. 2733-2740 8 p.

Research output: Contribution to journalArticle

Thyroid Gland
Central Nervous System
Thyroid Hormones
Hypothyroidism
Prodrugs
1 Citation (Scopus)

Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma

Abdel-Khalik, J., Crick, P. J., Yutuc, E., De Barber, A., Duell, P., Steiner, R. D., Laina, I., Wang, Y. & Griffiths, W. J., Jan 1 2018, (Accepted/In press) In : Biochimie.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Cerebrospinal Fluid
Plasmas
Acids
Biosynthesis