Research Output 2012 2019

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2019

Assessment of human pancreas cancer tissue and precursor lesions via a fluorophore with inherent PDAC selectivity

Munhenzva, I. R., Barth, C. W., Sibrian-Vazquez, M., Wang, L. G., Escobedo, J. O., Gibbs, S. & Strongin, R. M., Jan 1 2019, In : Methods.

Research output: Contribution to journalArticle

Fluorophores
Pancreatic Neoplasms
Adenocarcinoma
Tissue
Ducts

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

Coleman, D. J., Gao, L., King, C. J., Schwartzman, J., Urrutia, J., Sehrawat, A., Tayou, J., Balter, A., Burchard, J., Chiotti, K. E., Derrick, D. S., Sun, D., Xia, Z., Heiser, L. & Alumkal, J., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Androgen Receptors
Castration
Prostatic Neoplasms
RNA Sequence Analysis
Neoplasms

Diagnostic performance of receptor-specific surgical specimen staining correlates with receptor expression level

Schaefer, J. M., Barth, C. W., Davis, S. C. & Gibbs, S., Feb 1 2019, In : Journal of biomedical optics. 24, 2, p. 1-9 9 p.

Research output: Contribution to journalArticle

staining
margins
Imaging techniques
Coloring Agents
Contrast Media
1 Citation (Scopus)

Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer

Coleman, D. J., Gao, L., Schwartzman, J., Korkola, J., Sampson, D., Derrick, D. S., Urrutia, J., Balter, A., Burchard, J., King, C. J., Chiotti, K. E., Heiser, L. & Alumkal, J., Dec 1 2019, In : Scientific Reports. 9, 1, 3823.

Research output: Contribution to journalArticle

Open Access
Castration
Prostatic Neoplasms
Maintenance
Androgen Receptors
Cell Line
1 Citation (Scopus)

The role of coagulation and platelets in colon cancer-associated thrombosis

Mitrugno, A., Tassi Yunga, S., Sylman, J. L., Zilberman-Rudenko, J., Shirai, T., Hebert, J. F., Kayton, R., Zhang, Y., Nan, X., Shatzel, J. J., Esener, S., Duvernay, M. T., Hamm, H. E., Gruber, A., Williams, C. D., Takata, Y., Armstrong, R., Morgan, T. & McCarty, O., Feb 1 2019, In : American journal of physiology. Cell physiology. 316, 2, p. C264-C273

Research output: Contribution to journalArticle

Colonic Neoplasms
Thrombosis
Blood Platelets
Neoplasms
Cell Communication

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

Smith, R., Devlin, K., Kilburn, D., Gross, S., Sudar, D., Bucher, E., Nederlof, M., Dane, M., Gray, J. W., Heiser, L. & Korkola, J., May 21 2019, In : Journal of visualized experiments : JoVE. 147

Research output: Contribution to journalArticle

Microarrays
Assays
Proteins
Complex Mixtures
Phenotype
2018
16 Citations (Scopus)

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

Sehrawat, A., Gao, L., Wang, Y., Bankhead, A., McWeeney, S., King, C. J., Schwartzman, J., Urrutia, J., Bisson, W. H., Coleman, D. J., Joshi, S. K., Kim, D. H., Sampson, D. A., Weinmann, S., Kallakury, B. V. S., Berry, D. L., Haque, R., Van Den Eeden, S. K., Sharma, S., Bearss, J. & 4 others, Beer, T. T., Thomas, G., Heiser, L. & Alumkal, J., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. E4179-E4188

Research output: Contribution to journalArticle

Gene Regulatory Networks
Neoplasm Genes
Lysine
Prostatic Neoplasms
Castration
6 Citations (Scopus)

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

Watson, S. S., Dane, M., Chin, K-Y., Tatarova, Z., Liu, M., Liby, T., Thompson, W., Smith, R., Nederlof, M., Bucher, E., Kilburn, D., Whitman, M., Sudar, D., Mills, G., Heiser, L., Jonas, O., Gray, J. & Korkola, J., Jan 1 2018, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Breast Neoplasms
Ligands
Cell Line
Hepatocyte Growth Factor
7 Citations (Scopus)

Myeloid-Derived Suppressor Cell Membrane-Coated Magnetic Nanoparticles for Cancer Theranostics by Inducing Macrophage Polarization and Synergizing Immunogenic Cell Death

Yu, G. T., Rao, L., Wu, H., Yang, L. L., Bu, L. L., Deng, W. W., Wu, L., Nan, X., Zhang, W. F., Zhao, X. Z., Liu, W. & Sun, Z. J., Sep 12 2018, In : Advanced Functional Materials. 28, 37, 1801389.

Research output: Contribution to journalArticle

suppressors
macrophages
Macrophages
Cell death
Cell membranes

Nile Red derivatives enable improved ratiometric imaging for nerve-specific contrast

Korber, J. R., Barth, C. W. & Gibbs, S., Jul 1 2018, In : Journal of Biomedical Optics. 23, 7, 076002.

Research output: Contribution to journalArticle

Fluorophores
nerves
Tissue
Derivatives
Imaging techniques
6 Citations (Scopus)

Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals

Su, Y., Pelz, C., Huang, T., Torkenczy, K., Wang, X., Cherry, A., Daniel, C. J., Liang, J., Nan, X., Dai, M., Adey, A., Impey, S. & Sears, R., Nov 1 2018, In : Genes & development. 32, 21-22, p. 1398-1419 22 p.

Research output: Contribution to journalArticle

Nuclear Pore
Post Translational Protein Processing
Chromatin
Histone Code
Gene Expression
7 Citations (Scopus)

Simultaneous Multicolor Single-Molecule Tracking with Single-Laser Excitation via Spectral Imaging

Huang, T., Phelps, C., Wang, J., Lin, L. J., Bittel, A., Scott, Z., Jacques, S., Gibbs, S., Gray, J. & Nan, X., Jan 23 2018, In : Biophysical Journal. 114, 2, p. 301-310 10 p.

Research output: Contribution to journalArticle

Lasers
Cell Tracking
Biological Phenomena
Photons
Calibration
2 Citations (Scopus)

Superresolution microscopy with novel BODIPY-based fluorophores

Bittel, A. M., Saldivar, I. S., Dolman, N. J., Nan, X. & Gibbs, S., Jan 1 2018, In : PLoS One. 13, 10, p. e0206104

Research output: Contribution to journalArticle

Fluorophores
fluorescent dyes
Microscopy
microscopy
Microscopic examination
4 Citations (Scopus)

Varied Length Stokes Shift BODIPY-Based Fluorophores for Multicolor Microscopy

Bittel, A. M., Davis, A. M., Wang, L., Nederlof, M. A., Escobedo, J. O., Strongin, R. M. & Gibbs, S., Dec 1 2018, In : Scientific Reports. 8, 1, 4590.

Research output: Contribution to journalArticle

Boron
Fluorophores
Microscopic examination
Fluorescence microscopy
Color
2017
3 Citations (Scopus)

Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

Rahman, M., MacNeil, S. M., Jenkins, D. F., Shrestha, G., Wyatt, S. R., McQuerry, J. A., Piccolo, S. R., Heiser, L., Gray, J., Johnson, W. E. & Bild, A. H., Apr 26 2017, In : Genome Medicine. 9, 1, 40.

Research output: Contribution to journalArticle

Growth Factor Receptors
Breast Neoplasms
Phenotype
Pharmaceutical Preparations
Growth
1 Citation (Scopus)

Analysis of K-Ras interactions by biotin ligase tagging

Ritchie, C., Mack, A., Harper, L., Alfadhli, A., Stork, P., Nan, X. & Barklis, E., Jul 1 2017, In : Cancer Genomics and Proteomics. 14, 4, p. 225-239 15 p.

Research output: Contribution to journalArticle

Ligases
Biotin
ras Proteins
Cells
Prenylation
6 Citations (Scopus)

Assessment of roles for the rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: A spatial systems approach

Ngo, A. T. P., Thierheimer, M. L. D., Babur, O., Rocheleau, A. D., Huang, T., Pang, J., Rigg, R. A., Mitrugno, A., Theodorescu, D., Burchard, J., Nan, X., Demir, E., McCarty, O. & Aslan, J., Apr 7 2017, In : American Journal of Physiology - Cell Physiology. 312, 4, p. C527-C536

Research output: Contribution to journalArticle

rho-Specific Guanine Nucleotide Dissociation Inhibitors
Guanine Nucleotide Dissociation Inhibitors
Systems Analysis
Blood Platelets
Protein Kinase C
18 Citations (Scopus)

Combating subclonal evolution of resistant cancer phenotypes

Brady, S. W., McQuerry, J. A., Qiao, Y., Piccolo, S. R., Shrestha, G., Jenkins, D. F., Layer, R. M., Pedersen, B. S., Miller, R. H., Esch, A., Selitsky, S. R., Parker, J. S., Anderson, L. A., Dalley, B. K., Factor, R. E., Reddy, C. B., Boltax, J. P., Li, D. Y., Moos, P. J., Gray, J. & 8 others, Heiser, L., Buys, S. S., Cohen, A. L., Johnson, W. E., Quinlan, A. R., Marth, G., Werner, T. L. & Bild, A. H., Dec 1 2017, In : Nature Communications. 8, 1, 1231.

Research output: Contribution to journalArticle

phenotype
Chemotherapy
cancer
drugs
Phenotype
9 Citations (Scopus)

Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

Hill, S. M., Nesser, N. K., Johnson-Camacho, K., Jeffress, M., Johnson, A., Boniface, C., Spencer, S. E. F., Lu, Y., Heiser, L., Lawrence, Y., Pande, N. T., Korkola, J., Gray, J., Mills, G., Mukherjee, S. & Spellman, P., Jan 25 2017, In : Cell Systems. 4, 1, p. 73-83.e10

Research output: Contribution to journalArticle

Phosphoproteins
Protein Array Analysis
Receptor Protein-Tyrosine Kinases
Proteins
Phosphotransferases
9 Citations (Scopus)

Direct administration of nerve-specific contrast to improve nerve sparing radical prostatectomy

Barth, C. W. & Gibbs, S., 2017, In : Theranostics. 7, 3, p. 573-593 21 p.

Research output: Contribution to journalArticle

Prostatectomy
Fluorescence
Adipose Tissue
Computer-Assisted Surgery
Nerve Tissue
8 Citations (Scopus)

Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging

Wang, L., Barth, C. W., Sibrian-Vazquez, M., Escobedo, J. O., Lowry, M., Muschler, J., Li, H., Gibbs, S. & Strongin, R. M., Jan 31 2017, In : ACS Omega. 2, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

Infrared radiation
Fluorescent Dyes
Imaging techniques
Tissue
Molecular Probes
21 Citations (Scopus)

HER2 reactivation through acquisition of the HER2 L755S mutation as a mechanism of acquired resistance to HER2-targeted therapy in HER2+ breast cancer

Xu, X., De Angelis, C., Burke, K. A., Nardone, A., Hu, H., Qin, L., Veeraraghavan, J., Sethunath, V., Heiser, L., Wang, N., Ng, C. K. Y., Chen, E. S., Renwick, A., Wang, T., Nanda, S., Shea, M., Mitchell, T., Rajendran, M., Waters, I., Zabransky, D. J. & 14 others, Scott, K. L., Gutierrez, C., Nagi, C., Geyer, F. C., Chamness, G. C., Park, B. H., Shaw, C. A., Hilsenbeck, S. G., Rimawi, M. F., Gray, J., Weigelt, B., Reis-Filho, J. S., Osborne, C. K. & Schiff, R., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5123-5134 12 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Mutation
Cell Line
Small Interfering RNA
Therapeutics
2 Citations (Scopus)

Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer

King, C. J., Woodward, J., Schwartzman, J., Coleman, D. J., Lisac, R., Wang, N. J., Hook, K. V., Gao, L., Urrutia, J., Dane, M. A., Heiser, L. & Alumkal, J., Jan 1 2017, In : Oncotarget. 8, 67, p. 111084-111095 12 p.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Neoplasms
Drug Resistance
Genes
9 Citations (Scopus)

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

Farrell, A., Joly, M. M., Allen-Petersen, B. L., Worth, P. J., Lanciault, C., Sauer, D., Link, J., Pelz, C., Heiser, L., Morton, J. P., Muthalagu, N., Hoffman, M. T., Manning, S. L., Pratt, E. D., Kendsersky, N. D., Egbukichi, N., Amery, T. S., Thoma, M. C., Jenny, Z. P., Rhim, A. D. & 5 others, Murphy, D. J., Sansom, O. J., Crawford, H. C., Sheppard, B. & Sears, R., Dec 1 2017, In : Nature Communications. 8, 1, 1728.

Research output: Contribution to journalArticle

Synaptophysin
plastic properties
markers
Plasticity
Tumors
7 Citations (Scopus)

Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery

Barth, C. W., Schaefer, J. M., Rossi, V. M., Davis, S. C. & Gibbs, S., 2017, In : Theranostics. 7, 19, p. 4722-4734 13 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Staining and Labeling
Neoplasms
Area Under Curve
Segmental Mastectomy
5 Citations (Scopus)

Pathway-enriched gene signature associated with 53BP1 response to PARP inhibition in triple-negative breast cancer

Hassan, S., Esch, A., Liby, T., Gray, J. & Heiser, L., Dec 1 2017, In : Molecular Cancer Therapeutics. 16, 12, p. 2892-2901 10 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Genes
DNA Damage
Biomarkers
Breast Neoplasms
3 Citations (Scopus)

Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics

Hafner, M., Heiser, L., Williams, E. H., Niepel, M., Wang, N. J., Korkola, J., Gray, J. & Sorger, P. K., Nov 7 2017, In : Scientific data. 4, 170166.

Research output: Contribution to journalArticle

Breast Cancer
quantification
Quantification
Cancer
Drugs
7 Citations (Scopus)

Quantitating morphological changes in biological samples during scanning electron microscopy sample preparation with correlative super-resolution microscopy

Zhang, Y., Huang, T., Jorgens, D., Nickerson, A., Lin, L. J., Pelz, J., Gray, J., Lopez, C. & Nan, X., May 1 2017, In : PLoS One. 12, 5, e0176839.

Research output: Contribution to journalArticle

Electron Scanning Microscopy
Electron microscopy
Microscopy
microscopy
Drying
9 Citations (Scopus)

Superresolution imaging of clinical formalin fixed paraffin embedded breast cancer with single molecule localization microscopy

Creech, M. K., Wang, J., Nan, X. & Gibbs, S., Jan 18 2017, In : Scientific Reports. 7, 40766.

Research output: Contribution to journalArticle

Paraffin
Formaldehyde
Breast Neoplasms
Nuclear Lamina
Astigmatism
58 Citations (Scopus)

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., Kuleshov, M. V., Ma'ayan, A., Stathias, V., Terryn, R., Cooper, D., Forlin, M., Koleti, A., Vidovic, D., Chung, C., Schürer, S. C. & 87 others, Vasiliauskas, J., Pilarczyk, M., Shamsaei, B., Fazel, M., Ren, Y., Niu, W., Clark, N. A., White, S., Mahi, N., Zhang, L., Kouril, M., Reichard, J. F., Sivaganesan, S., Medvedovic, M., Meller, J., Koch, R. J., Birtwistle, M. R., Iyengar, R., Sobie, E. A., Azeloglu, E. U., Kaye, J., Osterloh, J., Haston, K., Kalra, J., Finkbiener, S., Li, J., Milani, P., Adam, M., Escalante-Chong, R., Sachs, K., Lenail, A., Ramamoorthy, D., Fraenkel, E., Daigle, G., Hussain, U., Coye, A., Rothstein, J., Sareen, D., Ornelas, L., Banuelos, M., Mandefro, B., Ho, R., Svendsen, C. N., Lim, R. G., Stocksdale, J., Casale, M. S., Thompson, T. G., Wu, J., Thompson, L. M., Dardov, V., Venkatraman, V., Matlock, A., Van Eyk, J. E., Jaffe, J. D., Papanastasiou, M., Subramanian, A., Golub, T. R., Erickson, S. D., Fallahi-Sichani, M., Hafner, M., Gray, N. S., Lin, J. R., Mills, C. E., Muhlich, J. L., Niepel, M., Shamu, C. E., Williams, E. H., Wrobel, D., Sorger, P. K., Heiser, L., Gray, J., Korkola, J., Mills, G., LaBarge, M., Feiler, H., Dane, M. A., Bucher, E., Nederlof, M., Sudar, D., Gross, S., Kilburn, D. F., Smith, R., Devlin, K., Margolis, R., Derr, L., Lee, A. & Pillai, A., Jan 1 2017, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

Cataloging
Libraries
Inborn Genetic Diseases
Molecular Imaging
Neurodegenerative Diseases
2016
7 Citations (Scopus)

Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor

Coleman, D. J., Van Hook, K., King, C. J., Schwartzman, J., Lisac, R., Urrutia, J., Sehrawat, A., Woodward, J., Wang, N. J., Gulati, R., Thomas, G., Beer, T. T., Gleave, M., Korkola, J., Gao, L., Heiser, L. & Alumkal, J., 2016, In : Oncotarget. 7, 26, p. 40690 1 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Castration
Prostatic Neoplasms
MDV 3100
2 Citations (Scopus)

Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin

Sylman, J. L., Daalkhaijav, U., Zhang, Y., Gray, E. M., Farhang, P. A., Chu, T. T., Zilberman-Rudenko, J., Puy, C., Tucker, E., Smith, S. A., Morrissey, J. H., Walker, T. W., Nan, X., Gruber, A. & McCarty, O., Dec 8 2016, (Accepted/In press) In : Annals of Biomedical Engineering. p. 1-13 13 p.

Research output: Contribution to journalArticle

Coagulation
Chemical activation
Ellagic acid
Gelation
Tissue
32 Citations (Scopus)

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

Fu, X., Jeselsohn, R., Pereira, R., Hollingsworth, E. F., Creighton, C. J., Li, F., Shea, M., Nardone, A., De Angelis, C., Heiser, L., Anur, P., Wang, N., Grasso, C. S., Spellman, P., Griffith, O. L., Tsimelzon, A., Gutierrez, C., Huang, S., Edwards, D. P., Trivedi, M. V. & 7 others, Rimawi, M. F., Lopez-Terrada, D., Hilsenbeck, S. G., Gray, J., Brown, M., Osborne, C. K. & Schiff, R., Oct 25 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 43, p. E6600-E6609

Research output: Contribution to journalArticle

Interleukin-8
Transcriptome
Estrogen Receptors
Breast Neoplasms
Hepatocyte Nuclear Factor 3-alpha
5 Citations (Scopus)

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

Hu, Z., Mao, J. H., Curtis, C., Huang, G., Gu, S., Heiser, L., Lenburg, M. E., Korkola, J., Bayani, N., Samarajiwa, S., Seoane, J. A., Dane, M., Esch, A., Feiler, H., Wang, N. J., Hardwicke, M. A., Laquerre, S., Jackson, J., Wood, K., Weber, B. & 5 others, Spellman, P., Aparicio, S., Wooster, R., Caldas, C. & Gray, J., Jul 1 2016, In : Breast Cancer Research. 18, 1, 70.

Research output: Contribution to journalArticle

Spindle Apparatus
Gene Regulatory Networks
Up-Regulation
Genome
Breast Neoplasms
76 Citations (Scopus)

Inferring causal molecular networks: Empirical assessment through a community-based effort

Hill, S. M., Heiser, L., Cokelaer, T., Unger, M., Nesser, N. K., Carlin, D. E., Zhang, Y., Sokolov, A., Paull, E. O., Wong, C. K., Graim, K., Bivol, A., Wang, H., Zhu, F., Afsari, B., Danilova, L. V., Favorov, A. V., Lee, W. S., Taylor, D., Hu, C. W. & 18 others, Long, B. L., Noren, D. P., Bisberg, A. J., Mills, G., Gray, J., Kellen, M., Norman, T., Friend, S., Qutub, A. A., Fertig, E. J., Guan, Y., Song, M., Stuart, J. M., Spellman, P., Koeppl, H., Stolovitzky, G., Saez-Rodriguez, J. & Mukherjee, S., Mar 30 2016, In : Nature Methods. 13, 4, p. 310-318 9 p.

Research output: Contribution to journalArticle

Phosphoproteins
Learning
Nonlinear Dynamics
Computer Simulation
Visualization
8 Citations (Scopus)

Methodology for quantitative characterization of fluorophore photoswitching to predict superresolution microscopy image quality

Bittel, A. M., Nickerson, A., Saldivar, I. S., Dolman, N. J., Nan, X. & Gibbs, S., Jul 14 2016, In : Scientific Reports. 6, 29687.

Research output: Contribution to journalArticle

Fluorophores
Image quality
Microscopic examination
Molecules
Polyvinyl Alcohol
11 Citations (Scopus)

PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder

Brown, A., Patel, S., Ward, C., Lorenz, A., Ortiz, M., DuRoss, A., Wieghardt, F., Esch, A., Otten, E. G., Heiser, L., Korolchuk, V. I., Sun, C., Sarkar, S. & Sahay, G., Aug 30 2016, In : Scientific Reports. 6, 31750.

Research output: Contribution to journalArticle

Type C Niemann-Pick Disease
Micelles
Cholesterol
Lipids
Cyclodextrins
15 Citations (Scopus)

Ras dimer formation as a new signaling mechanism and potential cancer therapeutic target

Chen, M., Peters, A., Huang, T. & Nan, X., Mar 1 2016, In : Mini-Reviews in Medicinal Chemistry. 16, 5, p. 391-403 13 p.

Research output: Contribution to journalArticle

ras Proteins
Cell Physiological Phenomena
Membranes
Monomeric GTP-Binding Proteins
Guanosine Triphosphate
63 Citations (Scopus)

Tumor-derived cell lines as molecular models of cancer pharmacogenomics

Goodspeed, A., Heiser, L., Gray, J. & Costello, J. C., Jan 1 2016, In : Molecular Cancer Research. 14, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Molecular Models
Pharmacogenetics
Tumor Cell Line
Neoplasms
Cell Line
2015
4 Citations (Scopus)

A network-based model of oncogenic collaboration for prediction of drug sensitivity

Laderas, T. G., Heiser, L. & Sonmez, M. K., 2015, In : Frontiers in Genetics. 6, DEC, 00341.

Research output: Contribution to journalArticle

Oncogenes
Pharmaceutical Preparations
Mutation
Precision Medicine
Breast Neoplasms
15 Citations (Scopus)

Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging

Bao, K., Nasr, K. A., Hyun, H., Lee, J. H., Gravier, J., Gibbs, S. & Choi, H. S., 2015, In : Theranostics. 5, 6, p. 609-617 9 p.

Research output: Contribution to journalArticle

pamidronate
Hydrophobic and Hydrophilic Interactions
Bone and Bones
Calcinosis
Optical Imaging
1 Citation (Scopus)

Critical Behavior of Subcellular Density Organization During Neutrophil Activation and Migration

Baker-Groberg, S. M., Phillips, K. G., Healy, L. D., Itakura, A., Porter, J. E., Newton, P. K., Nan, X. & McCarty, O., Jun 3 2015, In : Cellular and Molecular Bioengineering. 8, 4, p. 543-552 10 p.

Research output: Contribution to journalArticle

Neutrophils
Neutrophil Activation
Critical Behavior
Migration
Activation
10 Citations (Scopus)

Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer

Korkola, J., Collisson, E. A., Heiser, L., Oates, C., Bayani, N., Itani, S., Esch, A., Thompson, W., Griffith, O. L., Wang, N. J., Kuo, W. L., Cooper, B., Billig, J., Ziyad, S., Hung, J. L., Feiler, H., Lu, Y., Mills, G., Spellman, P., Tomlin, C. & 3 others, Mukherjee, S., Gray, J. & Jakkula, L., Jul 16 2015, In : PLoS One. 10, 7, e0133219.

Research output: Contribution to journalArticle

phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases
breast neoplasms
Breast Neoplasms
mutation
2 Citations (Scopus)

Erratum to Modeling precision treatment of breast cancer [Genome Biology, 14, (2013), R110]

Daemen, A., Griffith, O. L., Heiser, L., Wang, N. J., Enache, O. M., Sanborn, Z., Pepin, F., Durinck, S., Korkola, J., Griffith, M., Hur, J. S., Huh, N., Chung, J., Cope, L., Fackler, M. J., Umbricht, C., Sukumar, S., Seth, P., Sukhatme, V. P., Jakkula, L. R. & 7 others, Lu, Y., Mills, G., Cho, R. J., Collisson, E. A., van't Veer, L. J., Spellman, P. & Gray, J., May 12 2015, In : Genome Biology. 16, 1, 95.

Research output: Contribution to journalArticle

breast neoplasms
cancer
genome
Genome
Breast Neoplasms
2 Citations (Scopus)

Photoactivated localization microscopy with bimolecular fluorescence complementation (Bifc-palm)

Nickerson, A., Huang, T., Lin, L. J. & Nan, X., Dec 22 2015, In : Journal of Visualized Experiments. 2015, 106, e53154.

Research output: Contribution to journalArticle

Microscopy
Microscopic examination
Fluorescence
Proteins
Molecules
9 Citations (Scopus)

Polymeric Micelles as Carriers for Nerve-Highlighting Fluorescent Probe Delivery

Hackman, K. M., Doddapaneni, B. S., Barth, C. W., Wierzbicki, I. H., Alani, A. W. G. & Gibbs, S., Oct 20 2015, In : Molecular Pharmaceutics. 12, 12, p. 4386-4394 9 p.

Research output: Contribution to journalArticle

Micelles
Fluorescent Dyes
Fluorescence
Computer-Assisted Surgery
Optical Imaging
95 Citations (Scopus)

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

Nan, X., Tamgüney, T. M., Collisson, E. A., Lin, L. J., Pitt, C., Galeas, J., Lewis, S., Gray, J., McCormick, F. & Chu, S., Jun 30 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 7996-8001 6 p.

Research output: Contribution to journalArticle

Guanosine Triphosphate
Mitogen-Activated Protein Kinases
Sarcoma
Dimerization
Cell Membrane
12 Citations (Scopus)

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

Lue, H. W., Cole, B., Rao, S. A. M., Podolak, J., Van Gaest, A., King, C., Eide, C. A., Wilmot, B., Xue, C., Spellman, P., Heiser, L., Tyner, J. & Thomas, G., 2015, In : Oncotarget. 6, 42, p. 44675-44687 13 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Cell Survival
Cell Proliferation
Organ Size
12 Citations (Scopus)

Transmission electron microscopy as an orthogonal method to characterize protein aggregates

Sung, J. J., Pardeshi, N. N., Mulder, A., Mulligan, S. K., Quispe, J., On, K., Carragher, B., Potter, C. S., Carpenter, J. F. & Schneemann, A., 2015, In : Journal of Pharmaceutical Sciences. 104, 2, p. 750-759 10 p.

Research output: Contribution to journalArticle

Transmission Electron Microscopy
Negative Staining
Proteins
Particle Size
Nanoparticles
38 Citations (Scopus)

Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with Anti-HER2 therapy

Giuliano, M., Hu, H., Wang, Y. C., Fu, X., Nardone, A., Herrera, S., Mao, S., Contreras, A., Gutierrez, C., Wang, T., Hilsenbeck, S. G., Angelis, C. D., Wang, N. J., Heiser, L., Gray, J., Lopez-Tarruella, S., Pavlick, A. C., Trivedi, M. V., Chamness, G. C., Chang, J. C. & 3 others, Osborne, C. K., Rimawi, M. F. & Schiff, R., Sep 1 2015, In : Clinical Cancer Research. 21, 17, p. 3995-4003 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Cell Survival
Up-Regulation
Breast Neoplasms
Therapeutics