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2020

Quantification of fluorophore distribution and therapeutic response in matched in vivo and ex vivo pancreatic cancer model systems

Solanki, A., King, D., Thibault, G., Wang, L. & Gibbs, S. L., Jan 1 2020, In : PloS one. 15, 2, e0229407.

Research output: Contribution to journalArticle

Open Access
2019

Annot: A Django-based sample, reagent, and experiment metadata tracking system

Bucher, E., Claunch, C. J., Hee, D., Smith, R. L., Devlin, K., Thompson, W., Korkola, J. E. & Heiser, L. M., Nov 1 2019, In : BMC bioinformatics. 20, 1, 542.

Research output: Contribution to journalArticle

Open Access

Assessment of human pancreas cancer tissue and precursor lesions via a fluorophore with inherent PDAC selectivity

Munhenzva, I. R., Barth, C. W., Sibrian-Vazquez, M., Wang, L. G., Escobedo, J. O., Gibbs, S. & Strongin, R. M., Jan 1 2019, In : Methods.

Research output: Contribution to journalArticle

2 Scopus citations

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

Coleman, D. J., Gao, L., King, C. J., Schwartzman, J., Urrutia, J., Sehrawat, A., Tayou, J., Balter, A., Burchard, J., Chiotti, K. E., Derrick, D. S., Sun, D., Xia, Z., Heiser, L. & Alumkal, J., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

4 Scopus citations

Diagnostic performance of receptor-specific surgical specimen staining correlates with receptor expression level

Schaefer, J. M., Barth, C. W., Davis, S. C. & Gibbs, S. L., Feb 1 2019, In : Journal of biomedical optics. 24, 2, 026002.

Research output: Contribution to journalArticle

3 Scopus citations

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

Sutton, M. N., Lu, Z., Li, Y. C., Zhou, Y., Huang, T., Reger, A. S., Hurwitz, A. M., Palzkill, T., Logsdon, C., Liang, X., Gray, J. W., Nan, X., Hancock, J., Wahl, G. M. & Bast, R. C., Dec 10 2019, In : Cell Reports. 29, 11, p. 3448-3459.e6

Research output: Contribution to journalArticle

Open Access

High-throughput single-particle tracking reveals 1 nested membrane domains that dictate krasg12d 2 diffusion and trafficking

Lee, Y., Phelps, C., Huang, T., Mostofian, B., Wu, L., Zhang, Y., Tao, K., Chang, Y. H., Stork, P. J. S., Gray, J. W., Zuckerman, D. M. & Nan, X., Nov 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer

Coleman, D. J., Gao, L., Schwartzman, J., Korkola, J., Sampson, D., Derrick, D. S., Urrutia, J., Balter, A., Burchard, J., King, C. J., Chiotti, K. E., Heiser, L. & Alumkal, J., Dec 1 2019, In : Scientific Reports. 9, 1, 3823.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Targeting the mevalonate pathway to overcome acquired anti-HER2 treatment resistance in breast cancer

Sethunath, V., Hu, H., De Angelis, C., Veeraraghavan, J., Qin, L., Wang, N., Simon, L. M., Wang, T., Fu, X., Nardone, A., Pereira, R., Nanda, S., Griffith, O. L., Tsimelzon, A., Shaw, C., Chamness, G. C., Reis-Filho, J. S., Weigelt, B., Heiser, L. M., Hilsenbeck, S. G. & 5 others, Huang, S., Rimawi, M. F., Gray, J. W., Osborne, C. K. & Schiff, R., Jan 1 2019, In : Molecular Cancer Research. 17, 11, p. 2318-2330 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

The role of coagulation and platelets in colon cancer-associated thrombosis

Mitrugno, A., Tassi Yunga, S., Sylman, J. L., Zilberman-Rudenko, J., Shirai, T., Hebert, J. F., Kayton, R., Zhang, Y., Nan, X., Shatzel, J. J., Esener, S., Duvernay, M. T., Hamm, H. E., Gruber, A., Williams, C. D., Takata, Y., Armstrong, R., Morgan, T. & McCarty, O., Feb 1 2019, In : American journal of physiology. Cell physiology. 316, 2, p. C264-C273

Research output: Contribution to journalArticle

7 Scopus citations

Using microarrays to interrogate microenvironmental impact on cellular phenotypes in cancer

Smith, R., Devlin, K., Kilburn, D., Gross, S., Sudar, D., Bucher, E., Nederlof, M., Dane, M., Gray, J. W., Heiser, L. & Korkola, J. E., May 2019, In : Journal of Visualized Experiments. 2019, 147, e58957.

Research output: Contribution to journalArticle

1 Scopus citations
2018

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

Sehrawat, A., Gao, L., Wang, Y., Bankhead, A., McWeeney, S., King, C. J., Schwartzman, J., Urrutia, J., Bisson, W. H., Coleman, D. J., Joshi, S. K., Kim, D. H., Sampson, D. A., Weinmann, S., Kallakury, B. V. S., Berry, D. L., Haque, R., Van Den Eeden, S. K., Sharma, S., Bearss, J. & 4 others, Beer, T. T., Thomas, G., Heiser, L. & Alumkal, J., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. E4179-E4188

Research output: Contribution to journalArticle

34 Scopus citations

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

Watson, S. S., Dane, M., Chin, K-Y., Tatarova, Z., Liu, M., Liby, T., Thompson, W., Smith, R., Nederlof, M., Bucher, E., Kilburn, D., Whitman, M., Sudar, D., Mills, G., Heiser, L., Jonas, O., Gray, J. & Korkola, J., Jan 1 2018, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

10 Scopus citations

Myeloid-Derived Suppressor Cell Membrane-Coated Magnetic Nanoparticles for Cancer Theranostics by Inducing Macrophage Polarization and Synergizing Immunogenic Cell Death

Yu, G. T., Rao, L., Wu, H., Yang, L. L., Bu, L. L., Deng, W. W., Wu, L., Nan, X., Zhang, W. F., Zhao, X. Z., Liu, W. & Sun, Z. J., Sep 12 2018, In : Advanced Functional Materials. 28, 37, 1801389.

Research output: Contribution to journalArticle

31 Scopus citations

Nile Red derivatives enable improved ratiometric imaging for nerve-specific contrast

Korber, J. R., Barth, C. W. & Gibbs, S., Jul 1 2018, In : Journal of Biomedical Optics. 23, 7, 076002.

Research output: Contribution to journalArticle

3 Scopus citations

Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals

Su, Y., Pelz, C., Huang, T., Torkenczy, K., Wang, X., Cherry, A., Daniel, C. J., Liang, J., Nan, X., Dai, M., Adey, A., Impey, S. & Sears, R., Nov 1 2018, In : Genes & development. 32, 21-22, p. 1398-1419 22 p.

Research output: Contribution to journalArticle

13 Scopus citations

Simultaneous Multicolor Single-Molecule Tracking with Single-Laser Excitation via Spectral Imaging

Huang, T., Phelps, C., Wang, J., Lin, L. J., Bittel, A., Scott, Z., Jacques, S., Gibbs, S., Gray, J. & Nan, X., Jan 23 2018, In : Biophysical Journal. 114, 2, p. 301-310 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Superresolution microscopy with novel BODIPY-based fluorophores

Bittel, A. M., Saldivar, I. S., Dolman, N. J., Nan, X. & Gibbs, S., Jan 1 2018, In : PLoS One. 13, 10, p. e0206104

Research output: Contribution to journalArticle

3 Scopus citations

Varied Length Stokes Shift BODIPY-Based Fluorophores for Multicolor Microscopy

Bittel, A. M., Davis, A. M., Wang, L., Nederlof, M. A., Escobedo, J. O., Strongin, R. M. & Gibbs, S., Dec 1 2018, In : Scientific Reports. 8, 1, 4590.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

Rahman, M., MacNeil, S. M., Jenkins, D. F., Shrestha, G., Wyatt, S. R., McQuerry, J. A., Piccolo, S. R., Heiser, L. M., Gray, J. W., Johnson, W. E. & Bild, A. H., Apr 26 2017, In : Genome Medicine. 9, 1, 40.

Research output: Contribution to journalArticle

5 Scopus citations

Analysis of K-Ras interactions by biotin ligase tagging

Ritchie, C., Mack, A., Harper, L., Alfadhli, A., Stork, P. J. S., Nan, X. & Barklis, E., Jul 1 2017, In : Cancer Genomics and Proteomics. 14, 4, p. 225-239 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Assessment of roles for the rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: A spatial systems approach

Ngo, A. T. P., Thierheimer, M. L. D., Babur, O., Rocheleau, A. D., Huang, T., Pang, J., Rigg, R. A., Mitrugno, A., Theodorescu, D., Burchard, J., Nan, X., Demir, E., McCarty, O. & Aslan, J., Apr 7 2017, In : American Journal of Physiology - Cell Physiology. 312, 4, p. C527-C536

Research output: Contribution to journalArticle

7 Scopus citations

Combating subclonal evolution of resistant cancer phenotypes

Brady, S. W., McQuerry, J. A., Qiao, Y., Piccolo, S. R., Shrestha, G., Jenkins, D. F., Layer, R. M., Pedersen, B. S., Miller, R. H., Esch, A., Selitsky, S. R., Parker, J. S., Anderson, L. A., Dalley, B. K., Factor, R. E., Reddy, C. B., Boltax, J. P., Li, D. Y., Moos, P. J., Gray, J. W. & 8 others, Heiser, L. M., Buys, S. S., Cohen, A. L., Johnson, W. E., Quinlan, A. R., Marth, G., Werner, T. L. & Bild, A. H., Dec 1 2017, In : Nature communications. 8, 1, 1231.

Research output: Contribution to journalArticle

29 Scopus citations

Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

Hill, S. M., Nesser, N. K., Johnson-Camacho, K., Jeffress, M., Johnson, A., Boniface, C., Spencer, S. E. F., Lu, Y., Heiser, L. M., Lawrence, Y., Pande, N. T., Korkola, J. E., Gray, J. W., Mills, G. B., Mukherjee, S. & Spellman, P. T., Jan 25 2017, In : Cell Systems. 4, 1, p. 73-83.e10

Research output: Contribution to journalArticle

11 Scopus citations

Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin

Sylman, J. L., Daalkhaijav, U., Zhang, Y., Gray, E. M., Farhang, P. A., Chu, T. T., Zilberman-Rudenko, J., Puy, C., Tucker, E. I., Smith, S. A., Morrissey, J. H., Walker, T. W., Nan, X. L., Gruber, A. & McCarty, O. J. T., May 1 2017, In : Annals of Biomedical Engineering. 45, 5, p. 1328-1340 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Direct administration of nerve-specific contrast to improve nerve sparing radical prostatectomy

Barth, C. W. & Gibbs, S., 2017, In : Theranostics. 7, 3, p. 573-593 21 p.

Research output: Contribution to journalArticle

20 Scopus citations

Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging

Wang, L., Barth, C. W., Sibrian-Vazquez, M., Escobedo, J. O., Lowry, M., Muschler, J., Li, H., Gibbs, S. L. & Strongin, R. M., Jan 31 2017, In : ACS Omega. 2, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

HER2 reactivation through acquisition of the HER2 L755S mutation as a mechanism of acquired resistance to HER2-targeted therapy in HER2+ breast cancer

Xu, X., De Angelis, C., Burke, K. A., Nardone, A., Hu, H., Qin, L., Veeraraghavan, J., Sethunath, V., Heiser, L., Wang, N., Ng, C. K. Y., Chen, E. S., Renwick, A., Wang, T., Nanda, S., Shea, M., Mitchell, T., Rajendran, M., Waters, I., Zabransky, D. J. & 14 others, Scott, K. L., Gutierrez, C., Nagi, C., Geyer, F. C., Chamness, G. C., Park, B. H., Shaw, C. A., Hilsenbeck, S. G., Rimawi, M. F., Gray, J., Weigelt, B., Reis-Filho, J. S., Osborne, C. K. & Schiff, R., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5123-5134 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer

King, C. J., Woodward, J., Schwartzman, J., Coleman, D. J., Lisac, R., Wang, N. J., Hook, K. V., Gao, L., Urrutia, J., Dane, M. A., Heiser, L. M. & Alumkal, J. J., Jan 1 2017, In : Oncotarget. 8, 67, p. 111084-111095 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

Farrell, A. S., Joly, M. M., Allen-Petersen, B. L., Worth, P. J., Lanciault, C., Sauer, D., Link, J., Pelz, C., Heiser, L. M., Morton, J. P., Muthalagu, N., Hoffman, M. T., Manning, S. L., Pratt, E. D., Kendsersky, N. D., Egbukichi, N., Amery, T. S., Thoma, M. C., Jenny, Z. P., Rhim, A. D. & 5 others, Murphy, D. J., Sansom, O. J., Crawford, H. C., Sheppard, B. C. & Sears, R. C., Dec 1 2017, In : Nature communications. 8, 1, 1728.

Research output: Contribution to journalArticle

17 Scopus citations

Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery

Barth, C. W., Schaefer, J. M., Rossi, V. M., Davis, S. C. & Gibbs, S., 2017, In : Theranostics. 7, 19, p. 4722-4734 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Pathway-enriched gene signature associated with 53BP1 response to PARP inhibition in triple-negative breast cancer

Hassan, S., Esch, A., Liby, T., Gray, J. & Heiser, L., Dec 1 2017, In : Molecular Cancer Therapeutics. 16, 12, p. 2892-2901 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics

Hafner, M., Heiser, L., Williams, E. H., Niepel, M., Wang, N. J., Korkola, J., Gray, J. & Sorger, P. K., Nov 7 2017, In : Scientific data. 4, 170166.

Research output: Contribution to journalArticle

9 Scopus citations

Quantitating morphological changes in biological samples during scanning electron microscopy sample preparation with correlative super-resolution microscopy

Zhang, Y., Huang, T., Jorgens, D. M., Nickerson, A., Lin, L. J., Pelz, J., Gray, J. W., López, C. S. & Nan, X., May 2017, In : PloS one. 12, 5, e0176839.

Research output: Contribution to journalArticle

13 Scopus citations

Superresolution imaging of clinical formalin fixed paraffin embedded breast cancer with single molecule localization microscopy

Creech, M. K., Wang, J., Nan, X. & Gibbs, S., Jan 18 2017, In : Scientific Reports. 7, 40766.

Research output: Contribution to journalArticle

11 Scopus citations

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., Kuleshov, M. V., Ma'ayan, A., Stathias, V., Terryn, R., Cooper, D., Forlin, M., Koleti, A., Vidovic, D., Chung, C., Schürer, S. C. & 87 others, Vasiliauskas, J., Pilarczyk, M., Shamsaei, B., Fazel, M., Ren, Y., Niu, W., Clark, N. A., White, S., Mahi, N., Zhang, L., Kouril, M., Reichard, J. F., Sivaganesan, S., Medvedovic, M., Meller, J., Koch, R. J., Birtwistle, M. R., Iyengar, R., Sobie, E. A., Azeloglu, E. U., Kaye, J., Osterloh, J., Haston, K., Kalra, J., Finkbiener, S., Li, J., Milani, P., Adam, M., Escalante-Chong, R., Sachs, K., Lenail, A., Ramamoorthy, D., Fraenkel, E., Daigle, G., Hussain, U., Coye, A., Rothstein, J., Sareen, D., Ornelas, L., Banuelos, M., Mandefro, B., Ho, R., Svendsen, C. N., Lim, R. G., Stocksdale, J., Casale, M. S., Thompson, T. G., Wu, J., Thompson, L. M., Dardov, V., Venkatraman, V., Matlock, A., Van Eyk, J. E., Jaffe, J. D., Papanastasiou, M., Subramanian, A., Golub, T. R., Erickson, S. D., Fallahi-Sichani, M., Hafner, M., Gray, N. S., Lin, J. R., Mills, C. E., Muhlich, J. L., Niepel, M., Shamu, C. E., Williams, E. H., Wrobel, D., Sorger, P. K., Heiser, L., Gray, J., Korkola, J., Mills, G., LaBarge, M., Feiler, H., Dane, M. A., Bucher, E., Nederlof, M., Sudar, D., Gross, S., Kilburn, D. F., Smith, R., Devlin, K., Margolis, R., Derr, L., Lee, A. & Pillai, A., Jan 1 2017, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

73 Scopus citations
2016

Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor

Coleman, D. J., Van Hook, K., King, C. J., Schwartzman, J., Lisac, R., Urrutia, J., Sehrawat, A., Woodward, J., Wang, N. J., Gulati, R., Thomas, G., Beer, T. T., Gleave, M., Korkola, J., Gao, L., Heiser, L. & Alumkal, J., 2016, In : Oncotarget. 7, 26, p. 40690 1 p.

Research output: Contribution to journalArticle

7 Scopus citations

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

Fu, X., Jeselsohn, R., Pereira, R., Hollingsworth, E. F., Creighton, C. J., Li, F., Shea, M., Nardone, A., De Angelis, C., Heiser, L. M., Anur, P., Wang, N., Grasso, C. S., Spellman, P. T., Griffith, O. L., Tsimelzon, A., Gutierrez, C., Huang, S., Edwards, D. P., Trivedi, M. V. & 7 others, Rimawi, M. F., Lopez-Terrada, D., Hilsenbeck, S. G., Gray, J. W., Brown, M., Osborne, C. K. & Schiff, R., Oct 25 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 43, p. E6600-E6609

Research output: Contribution to journalArticle

43 Scopus citations

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

Hu, Z., Mao, J. H., Curtis, C., Huang, G., Gu, S., Heiser, L., Lenburg, M. E., Korkola, J. E., Bayani, N., Samarajiwa, S., Seoane, J. A., Dane, M., Esch, A., Feiler, H. S., Wang, N. J., Hardwicke, M. A., Laquerre, S., Jackson, J., Wood, K., Weber, B. & 5 others, Spellman, P. T., Aparicio, S., Wooster, R., Caldas, C. & Gray, J. W., Jul 1 2016, In : Breast Cancer Research. 18, 1, 70.

Research output: Contribution to journalArticle

6 Scopus citations

Inferring causal molecular networks: Empirical assessment through a community-based effort

Hill, S. M., Heiser, L. M., Cokelaer, T., Linger, M., Nesser, N. K., Carlin, D. E., Zhang, Y., Sokolov, A., Paull, E. O., Wong, C. K., Graim, K., Bivol, A., Wang, H., Zhu, F., Afsari, B., Danilova, L. V., Favorov, A. V., Lee, W. S., Taylor, D., Hu, C. W. & 115 others, Long, B. L., Noren, D. P., Bisberg, A. J., Mills, G. B., Gray, J. W., Kellen, M., Norman, T., Friend, S., Qutub, A. A., Fertig, E. J., Guan, Y., Song, M., Stuart, J. M., Spellman, P. T., Koeppl, H., Stolovitzky, G., Saez-Rodriguez, J., Mukherjee, S., Al-Ouran, R., Anton, B., Arodz, T., Sichani, O. A., Bagheri, N., Berlow, N., Bohler, A., Bonet, J., Bonneau, R., Budak, G., Bunescu, R., Caglar, M., Cai, B., Cai, C., Carlon, A., Chen, L., Ciaccio, M. F., Cooper, G., Coort, S., Creighton, C. J., Daneshmand, S. M. H., De La Fuente, A., Di Camillo, B., Dutta-Moscato, J., Emmett, K., Evelo, C., Fassia, M. K. H., Finotello, F., Finkle, J. D., Gao, X., Garcia-Garcia, J., Ghosh, S., Giaretta, A., Großeholz, R., Guinney, J., Hafemeister, C., Hahn, O., Haider, S., Hase, T., Hodgson, J., Hoff, B., Hsu, C. H., Hu, Y., Huang, X., Jalili, M., Jiang, X., Kacprowski, T., Kaderali, L., Kang, M., Kannan, V., Kikuchi, K., Kim, D. C., Kitano, H., Knapp, B., Komatsoulis, G., Krämer, A., Kursa, M. B., Kutmon, M., Li, Y., Liang, X., Liu, Z., Liu, Y., Lu, S., Lu, X., Manfrini, M., Matos, M. R. A., Meerzaman, D., Min, W., Müller, C. L., Neapolitan, R. E., Oliva, B., Opiyo, S. O., Pal, R., Palinkas, A., Planas-Iglesias, J., Poglayen, D., Sambo, F., Sanavia, T., Sharifi-Zarchi, A., Slawek, J., Streck, A., Strunz, S., Tegnér, J., Thobe, K., Toffolo, G. M., Trifoglio, E., Unger, M., Wan, Q., Welch, L., Wu, J. J., Xue, A. Y., Yamanaka, R., Yan, C., Zairis, S., Zengerling, M., Zenil, H. & Zi, Z., Mar 30 2016, In : Nature Methods. 13, 4, p. 310-322 13 p.

Research output: Contribution to journalArticle

97 Scopus citations

Methodology for quantitative characterization of fluorophore photoswitching to predict superresolution microscopy image quality

Bittel, A. M., Nickerson, A., Saldivar, I. S., Dolman, N. J., Nan, X. & Gibbs, S., Jul 14 2016, In : Scientific Reports. 6, 29687.

Research output: Contribution to journalArticle

9 Scopus citations

PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder

Brown, A., Patel, S., Ward, C., Lorenz, A., Ortiz, M., DuRoss, A., Wieghardt, F., Esch, A., Otten, E. G., Heiser, L. M., Korolchuk, V. I., Sun, C., Sarkar, S. & Sahay, G., Aug 30 2016, In : Scientific Reports. 6, 31750.

Research output: Contribution to journalArticle

13 Scopus citations

Ras dimer formation as a new signaling mechanism and potential cancer therapeutic target

Chen, M., Peters, A., Huang, T. & Nan, X., Mar 1 2016, In : Mini-Reviews in Medicinal Chemistry. 16, 5, p. 391-403 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Tumor-derived cell lines as molecular models of cancer pharmacogenomics

Goodspeed, A., Heiser, L., Gray, J. & Costello, J. C., Jan 1 2016, In : Molecular Cancer Research. 14, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

77 Scopus citations
2015

A network-based model of oncogenic collaboration for prediction of drug sensitivity

Laderas, T. G., Heiser, L. & Sonmez, M. K., 2015, In : Frontiers in Genetics. 6, DEC, 00341.

Research output: Contribution to journalArticle

4 Scopus citations

Cationic polymer modified mesoporous silica nanoparticles for targeted siRNA delivery to HER2+ breast cancer

Ngamcherdtrakul, W., Morry, J., Gu, S., Castro, D. J., Goodyear, S. M., Sangvanich, T., Reda, M. M., Lee, R., Mihelic, S. A., Beckman, B. L., Hu, Z., Gray, J. W. & Yantasee, W., May 13 2015, In : Advanced Functional Materials. 25, 18, p. 2646-2659 14 p.

Research output: Contribution to journalArticle

95 Scopus citations

Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging

Bao, K., Nasr, K. A., Hyun, H., Lee, J. H., Gravier, J., Gibbs, S. L. & Choi, H. S., Jan 1 2015, In : Theranostics. 5, 6, p. 609-617 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Critical Behavior of Subcellular Density Organization During Neutrophil Activation and Migration

Baker-Groberg, S. M., Phillips, K. G., Healy, L. D., Itakura, A., Porter, J. E., Newton, P. K., Nan, X. & McCarty, O. J. T., Dec 1 2015, In : Cellular and Molecular Bioengineering. 8, 4, p. 543-552 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer

Korkola, J. E., Collisson, E. A., Heiser, L., Oates, C., Bayani, N., Itani, S., Esch, A., Thompson, W., Griffith, O. L., Wang, N. J., Kuo, W. L., Cooper, B., Billig, J., Ziyad, S., Hung, J. L., Feiler, H., Lu, Y., Mills, G. B., Spellman, P. T., Tomlin, C. & 3 others, Mukherjee, S., Gray, J. W. & Jakkula, L., Jul 16 2015, In : PloS one. 10, 7, e0133219.

Research output: Contribution to journalArticle

11 Scopus citations

Disentangling multidimensional spatio-temporal data into their common and aberrant responses

Chang, Y. H., Korkola, J., Amin, D. N., Moasser, M. M., Carmena, J. M., Gray, J. W. & Tomlin, C. J., Apr 22 2015, In : PloS one. 10, 4, e0121607.

Research output: Contribution to journalArticle

1 Scopus citations