Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

Zhihong Zeng, Ismael J. Samudio, Weiguo Zhang, Zeev Estrov, Hélène Pelicano, David Harris, Olga Frolova, Numsen Hail, Wenjing Chen, Steven M. Kornblau, Peng Huang, Yiling Lu, Gordon B. Mills, Michael Andreeff, Marina Konopleva

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Medicine & Life Sciences