Zhengfeng Zhou

Research Associate Professor

    • 3569 Citations
    • 28 h-Index
    1992 …2019

    Research Output 1992 2018

    • 3569 Citations
    • 28 h-Index
    • 48 Article
    • 2 Chapter
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    Article
    2018

    Upregulation of functional Kv11.1a isoform expression by modified U1 small nuclear RNA

    Gong, Q., Stump, M. R. & Zhou, Z. Jan 30 2018 In : Gene. 641, p. 220-225 6 p.

    Research output: Research - peer-reviewArticle

    Introns
    Protein Isoforms
    Up-Regulation
    U1 small nuclear RNA
    RNA Splice Sites
    2015
    21 Citations

    Brief report: Oxidative stress mediates cardiomyocyte apoptosis in a human model of danon disease and heart failure

    Hashem, S. I., Perry, C. N., Bauer, M., Han, S., Clegg, S. D., Ouyang, K., Deacon, D. C., Spinharney, M., Panopoulos, A. D., Izpisua Belmonte, J. C., Frazer, K. A., Chen, J., Gong, Q., Zhou, Z., Chi, N. C. & Adler, E. D. Jul 1 2015 In : Stem Cells. 33, 7, p. 2343-2350 8 p.

    Research output: Research - peer-reviewArticle

    Glycogen Storage Disease Type IIb
    Induced Pluripotent Stem Cells
    Cardiac Myocytes
    Oxidative Stress
    Heart Failure
    14 Citations

    Pathogenesis of the novel autoimmune-associated long-QT syndrome

    Yue, Y., Castrichini, M., Srivastava, U., Fabris, F., Shah, K., Li, Z., Qu, Y., El-Sherif, N., Zhou, Z., January, C., Hussain, M. M., Jiang, X. C., Sobie, E. A., Wahren-Herlenius, M., Chahine, M., Capecchi, P. L., Laghi-Pasini, F., Lazzerini, P. E. & Boutjdir, M. Jul 28 2015 In : Circulation. 132, 4, p. 230-240 11 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Autoimmune Diseases
    Electrocardiography
    Cardiac Arrhythmias
    Guinea Pigs
    2014
    1 Citations

    Identification of Kv11.1 isoform switch as a novel pathogenic mechanism of long-QT syndrome

    Gong, Q., Stump, M. R., Deng, V., Zhang, L. & Zhou, Z. Aug 1 2014 In : Circulation: Cardiovascular Genetics. 7, 4, p. 482-490 9 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Protein Isoforms
    Mutation
    Introns
    Polyadenylation
    7 Citations

    Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome

    Gong, Q., Stump, M. R. & Zhou, Z. Apr 15 2014 In : Gene. 539, 2, p. 190-197 8 p.

    Research output: Research - peer-reviewArticle

    Nonsense Mediated mRNA Decay
    Long QT Syndrome
    Nonsense Codon
    Mutation
    Exons
    1 Citations
    Morpholinos
    Polyadenylation
    Antisense Oligonucleotides
    Introns
    Protein Isoforms
    2013
    7 Citations
    Long QT Syndrome
    Nonsense Codon
    Ether
    Genes
    Nonsense Mediated mRNA Decay
    2012
    11 Citations
    Long QT Syndrome
    Nonsense Codon
    Ether
    Genes
    Messenger RNA
    5 Citations

    Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome

    Stump, M. R., Gong, Q. & Zhou, Z. Aug 2 2012 In : PLoS One. 7, 8, e42552

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Ether
    Protein Isoforms
    Mutation
    Genes
    2011
    18 Citations
    Nonsense Mediated mRNA Decay
    Long QT Syndrome
    Morpholinos
    Frameshift Mutation
    Antisense Oligonucleotides
    6 Citations
    Long QT Syndrome
    Ether
    Mutation
    Genes
    RNA Splice Sites
    15 Citations

    Nonsense-mediated mRNA decay caused by a frameshift mutation in a large kindred of type 2 long QT syndrome

    Zarraga, I. G., Zhang, L., Stump, M. R., Gong, Q., Vincent, G. M. & Zhou, Z. Aug 2011 In : Heart Rhythm. 8, 8, p. 1200-1206 7 p.

    Research output: Research - peer-reviewArticle

    Nonsense Mediated mRNA Decay
    Long QT Syndrome
    Frameshift Mutation
    Mutation
    Nonsense Codon
    2010
    9 Citations

    Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms

    Gong, Q., Stump, M. R., Dunn, A. R., Deng, V. & Zhou, Z. Oct 15 2010 In : Journal of Biological Chemistry. 285, 42, p. 32233-32241 9 p.

    Research output: Research - peer-reviewArticle

    Polyadenylation
    Alternative Splicing
    Ether
    Protein Isoforms
    Genes
    33 Citations

    A major role for hERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer

    Hou, L., Deo, M., Furspan, P., Pandit, S. V., Mironov, S., Auerbach, D. S., Gong, Q., Zhou, Z., Berenfeld, O. & Jalife, J. Dec 10 2010 In : Circulation Research. 107, 12, p. 1503-1511 9 p.

    Research output: Research - peer-reviewArticle

    Ether
    Muscle Cells
    pamidronate
    Up-Regulation
    Action Potentials
    2008
    17 Citations

    A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome

    Gong, Q., Zhang, L., Moss, A. J., Vincent, G. M., Ackerman, M. J., Robinson, J. C., Jones, M. A., Tester, D. J. & Zhou, Z. Mar 2008 In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 502-509 8 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Ether
    Mutation
    Genes
    RNA Splice Sites
    33 Citations

    Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation

    Bhuiyan, Z. A., Momenah, T. S., Gong, Q., Amin, A. S., Ghamdi, S. A., Carvalho, J. S., Homfray, T., Mannens, M. M. A. M., Zhou, Z. & Wilde, A. A. M. Apr 2008 In : Heart Rhythm. 5, 4, p. 553-561 9 p.

    Research output: Research - peer-reviewArticle

    Cardiac Arrhythmias
    Mutation
    Genes
    Ion Channels
    Aptitude
    2007
    75 Citations

    Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome

    Gong, Q., Zhang, L., Vincent, G. M., Horne, B. D. & Zhou, Z. Jul 2007 In : Circulation. 116, 1, p. 17-24 8 p.

    Research output: Research - peer-reviewArticle

    Nonsense Mediated mRNA Decay
    Long QT Syndrome
    Nonsense Codon
    Ether
    Messenger RNA

    The mechanistic rote of KCNH2 gene L413P and L559H mutations in long QT syndrome

    Li, C. L., Hu, D. Y., Liu, W. L., Qi, S. Y., Wang, H. T., Li, L., Gong, Q. M. & Zhou, Z. F. Oct 2007 In : Zhonghua nei ke za zhi [Chinese journal of internal medicine]. 46, 10, p. 838-841 4 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Mutation
    Genes
    Proteins
    Mutant Proteins
    2006
    58 Citations

    Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome

    Gong, Q., Jones, M. A. & Zhou, Z. Feb 17 2006 In : Journal of Biological Chemistry. 281, 7, p. 4069-4074 6 p.

    Research output: Research - peer-reviewArticle

    Human Trafficking
    Long QT Syndrome
    Ether
    Pharmacology
    Genes
    260 Citations

    Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

    Anderson, C. L., Delisle, B. P., Anson, B. D., Kilby, J. A., Will, M. L., Tester, D. J., Gong, Q., Zhou, Z., Ackerman, M. J. & January, C. T. Jan 2006 In : Circulation. 113, 3, p. 365-373 9 p.

    Research output: Research - peer-reviewArticle

    Ether
    Phenotype
    Mutation
    Genes
    Protein Transport
    2005
    73 Citations

    Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway

    Gong, Q., Keeney, D. R., Molinari, M. & Zhou, Z. May 13 2005 In : Journal of Biological Chemistry. 280, 19, p. 19419-19425 7 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Proteasome Endopeptidase Complex
    Ubiquitin
    Proteins
    Degradation
    2004
    45 Citations

    Defective assembly and trafficking of mutant HERG channels with C-terminal truncations in long QT syndrome

    Gong, Q., Keeney, D. R., Robinson, J. C. & Zhou, Z. Dec 2004 In : Journal of Molecular and Cellular Cardiology. 37, 6, p. 1225-1233 9 p.

    Research output: Research - peer-reviewArticle

    Human Trafficking
    Long QT Syndrome
    Ether
    Genes
    Mutation
    38 Citations
    Human Trafficking
    Ether
    Pharmacology
    Genes
    Endoplasmic Reticulum
    133 Citations

    Postmortem molecular screening in unexplained sudden death

    Chugh, S. S., Senashova, O., Watts, A., Tran, P. T., Zhou, Z., Gong, Q., Titus, J. L. & Hayflick, S. J. May 5 2004 In : Journal of the American College of Cardiology. 43, 9, p. 1625-1629 5 p.

    Research output: Research - peer-reviewArticle

    Sudden Death
    Sudden Cardiac Death
    Genes
    Autopsy
    Cardiac Arrhythmias
    2002
    95 Citations
    Potassium Channels
    Glycosylation
    Ether
    Genes
    Proteins
    2001
    59 Citations

    Cocaine blocks HERG, but not KvLQT1+minK, potassium channels

    Zhang, S., Rajamani, S., Chen, Y., Gong, Q., Rong, Y., Zhou, Z., Ruoho, A. & January, C. T. 2001 In : Molecular Pharmacology. 59, 5, p. 1069-1076 8 p.

    Research output: Research - peer-reviewArticle

    Mink
    Potassium Channels
    Cocaine
    Sudden Death
    Cardiac Arrhythmias
    33 Citations

    Differences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndrome

    Studenik, C. R., Zhou, Z. & January, C. T. 2001 In : British Journal of Pharmacology. 132, 1, p. 85-92 8 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Action Potentials
    E 4031
    Congenital, Hereditary, and Neonatal Diseases and Abnormalities
    Muscle Cells
    2000
    2 Citations

    Defective protein trafficking of HERG K+ channels in human congenital long QT syndrome

    January, C. T., Gong, Q. & Zhou, Z. 2000 In : Pharmaceutical News. 7, 4, p. 27-34 8 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Protein Transport
    Mutation
    Endoplasmic Reticulum
    Proteolysis
    3 Citations
    Anti-Arrhythmia Agents
    Action Potentials
    dofetilide
    E 4031
    acetylstrophanthidin
    90 Citations

    Long QT syndrome: Cellular basis and arrhythmia mechanism in LQT2

    January, C. T., Gong, Q. & Zhou, Z. 2000 In : Journal of Cardiovascular Electrophysiology. 11, 12, p. 1413-1418 6 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Cardiac Arrhythmias
    Mutation
    Ether
    Genes
    1999
    146 Citations

    Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

    Zhou, Z., Vorperian, V. R., Gong, Q., Zhang, S. & January, C. T. 1999 In : Journal of Cardiovascular Electrophysiology. 10, 6, p. 836-843 8 p.

    Research output: Research - peer-reviewArticle

    Astemizole
    Histamine Antagonists
    Potassium Channels
    Ether
    Genes
    233 Citations
    Long QT Syndrome
    Potassium Channels
    Protein Transport
    Ether
    Pharmacology
    98 Citations

    Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current

    Drolet, B., Zhang, S., Deschênes, D., Rail, J., Nadeau, S., Zhou, Z., January, C. T. & Turgeon, J. 1999 In : Journal of Cardiovascular Electrophysiology. 10, 12, p. 1597-1604 8 p.

    Research output: Research - peer-reviewArticle

    Droperidol
    Potassium
    Guinea Pigs
    Butyrophenones
    Torsades de Pointes
    270 Citations

    Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

    Zhang, S., Zhou, Z., Gong, Q., Makielski, J. C. & January, C. T. May 14 1999 In : Circulation Research. 84, 9, p. 989-998 10 p.

    Research output: Research - peer-reviewArticle

    Potassium Channels
    Verapamil
    Mutation
    Diltiazem
    Nifedipine
    149 Citations

    Novel mechanism associated with an inherited cardiac arrhythmia: Defective protein trafficking by the mutant HERG (G601S) potassium channel

    Furutani, M., Trudeau, M. C., Hagiwara, N., Seki, A., Gong, Q., Zhou, Z., Imamura, S. I., Nagashima, H., Kasanuki, H., Takao, A., Momma, K., January, C. T., Robertson, G. A. & Matsuoka, R. May 4 1999 In : Circulation. 99, 17, p. 2290-2294 5 p.

    Research output: Research - peer-reviewArticle

    Potassium Channels
    Protein Transport
    Ether
    Cardiac Arrhythmias
    Genes
    1998
    48 Citations

    Both T- and L-type Ca2+ channels can contribute to excitation- contraction coupling in cardiac Purkinje cells

    Zhou, Z. & January, C. T. 1998 In : Biophysical Journal. 74, 4, p. 1830-1839 10 p.

    Research output: Research - peer-reviewArticle

    Excitation Contraction Coupling
    Purkinje Cells
    Sarcoplasmic Reticulum
    Signal Transduction
    Amphotericin B
    279 Citations

    HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects

    Zhou, Z., Gong, Q., Epstein, M. L. & January, C. T. Aug 14 1998 In : Journal of Biological Chemistry. 273, 33, p. 21061-21066 6 p.

    Research output: Research - peer-reviewArticle

    Defects
    Processing
    Proteins
    Long QT Syndrome
    Mutation
    119 Citations

    Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines

    Taglialatela, M., Pannaccione, A., Castaldo, P., Giorgio, G., Zhou, Z., January, C. T., Genovese, A., Marone, G. & Annunziato, L. Jul 1998 In : Molecular Pharmacology. 54, 1, p. 113-121 9 p.

    Research output: Research - peer-reviewArticle

    Non-Sedating Histamine H1 Antagonists
    Cetirizine
    Histamine H1 Receptors
    Ether
    Genes
    537 Citations

    Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

    Zhou, Z., Gong, Q., Ye, B., Fan, Z., Makielski, J. C., Robertson, G. A. & January, C. T. Jan 1998 In : Biophysical Journal. 74, 1, p. 230-241 12 p.

    Research output: Research - peer-reviewArticle

    HEK293 Cells
    Ether
    Temperature
    Genes
    Action Potentials
    1997
    159 Citations
    Cisapride
    Gastrointestinal Agents
    Ether
    Genes
    Tail
    59 Citations
    Cisapride
    Gastrointestinal Agents
    Ether
    Genes
    Tail
    1996
    94 Citations

    Torsade de pointes with an antihistamine metabolite: Potassium channel blockade with desmethylastemizole

    Vorperian, V. R., Zhou, Z., Mohammad, S., Hoon, T. J., Studenik, C. & January, C. T. Nov 15 1996 In : Journal of the American College of Cardiology. 28, 6, p. 1556-1561 6 p.

    Research output: Research - peer-reviewArticle

    Astemizole
    Torsades de Pointes
    Histamine Antagonists
    Potassium Channels
    desmethylastemizole
    1994
    3 Citations

    Delayed rectifier potassium current (IK) in latent atrial pacemaker cells isolated from cat right atrium

    Zhou, Z. & Lipsius, S. L. Feb 1994 In : Pflügers Archiv European Journal of Physiology. 426, 3-4, p. 341-347 7 p.

    Research output: Research - peer-reviewArticle

    Heart Atria
    Potassium
    Cats
    Pacemakers
    Chemical activation
    83 Citations

    T-Type Calcium Current in Latent Pacemaker Cells Isolated from Cat Right Atrium

    Zhou, Z. & Lipsius, S. L. Sep 1994 In : Journal of Molecular and Cellular Cardiology. 26, 9, p. 1211-1219 9 p.

    Research output: Research - peer-reviewArticle

    Heart Atria
    Cats
    Calcium
    Muscle Cells
    Patch-Clamp Techniques
    1993
    3 Citations

    Cellular mechanisms of right atrial latent pacemakers

    Lipsius, S. L., Rubenstein, D. S. & Zhou, Z. 1993 In : New Trends in Arrhythmias. 9, 1, p. 11-23 13 p.

    Research output: Research - peer-reviewArticle

    16 Citations
    Patch-Clamp Techniques
    Heart Atria
    Isoproterenol
    Cats
    Pacemakers
    80 Citations

    Na+-Ca2+ exchange current in latent pacemaker cells isolated from cat right atrium

    Zhou, Z. & Lipsius, S. L. 1993 In : Journal of Physiology. 466, p. 263-285 23 p.

    Research output: Research - peer-reviewArticle

    Heart Atria
    Cats
    Nystatin
    Ryanodine
    Isoproterenol
    1992
    31 Citations

    Properties of the pacemaker current (I(f)) in latent pacemaker cells isolated from cat right atrium

    Zhou, Z. & Lipsius, S. L. 1992 In : Journal of Physiology. 453, p. 503-523 21 p.

    Research output: Research - peer-reviewArticle

    Heart Atria
    Cats
    Cesium
    Nystatin
    Sinoatrial Node