Zhengfeng Zhou

Research Associate Professor

  • 3740 Citations
  • 29 h-Index
1992 …2019
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Research Output 1992 2018

  • 3740 Citations
  • 29 h-Index
  • 48 Article
  • 2 Chapter
2018
2 Citations

Nonsense-mediated mRNA decay of hERG mutations in long QT syndrome

Gong, Q. & Zhou, Z., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1684, p. 37-49 13 p. (Methods in Molecular Biology; vol. 1684)

Research output: Chapter in Book/Report/Conference proceedingChapter

Nonsense Mediated mRNA Decay
Long QT Syndrome
Nonsense Codon
Ether
Frameshift Mutation

Upregulation of functional Kv11.1a isoform expression by modified U1 small nuclear RNA

Gong, Q., Stump, M. R. & Zhou, Z., Jan 30 2018, In : Gene. 641, p. 220-225 6 p.

Research output: Contribution to journalArticle

Introns
Protein Isoforms
Up-Regulation
RNA Splice Sites
Polyadenylation
2017

Regulation of isoform expression by blocking polyadenylation signal sequences with morpholinos

Gong, Q. & Zhou, Z., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1565, p. 141-150 10 p. (Methods in Molecular Biology; vol. 1565)

Research output: Chapter in Book/Report/Conference proceedingChapter

Morpholinos
Polyadenylation
Protein Sorting Signals
Protein Isoforms
Gene Expression Regulation
2015
29 Citations

Brief report: Oxidative stress mediates cardiomyocyte apoptosis in a human model of danon disease and heart failure

Hashem, S. I., Perry, C. N., Bauer, M., Han, S., Clegg, S. D., Ouyang, K., Deacon, D. C., Spinharney, M., Panopoulos, A. D., Izpisua Belmonte, J. C., Frazer, K. A., Chen, J., Gong, Q., Zhou, Z., Chi, N. C. & Adler, E. D., Jul 1 2015, In : Stem Cells. 33, 7, p. 2343-2350 8 p.

Research output: Contribution to journalArticle

Glycogen Storage Disease Type IIb
Induced Pluripotent Stem Cells
Lysosomal-Associated Membrane Protein 2
Cardiac Myocytes
Oxidative Stress
17 Citations

Pathogenesis of the novel autoimmune-associated long-QT syndrome

Yue, Y., Castrichini, M., Srivastava, U., Fabris, F., Shah, K., Li, Z., Qu, Y., El-Sherif, N., Zhou, Z., January, C., Hussain, M. M., Jiang, X. C., Sobie, E. A., Wahren-Herlenius, M., Chahine, M., Capecchi, P. L., Laghi-Pasini, F., Lazzerini, P. E. & Boutjdir, M., Jul 28 2015, In : Circulation. 132, 4, p. 230-240 11 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Autoimmune Diseases
Electrocardiography
Cardiac Arrhythmias
Guinea Pigs
2014
3 Citations

Identification of Kv11.1 isoform switch as a novel pathogenic mechanism of long-QT syndrome

Gong, Q., Stump, M. R., Deng, V., Zhang, L. & Zhou, Z., Aug 1 2014, In : Circulation: Cardiovascular Genetics. 7, 4, p. 482-490 9 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Protein Isoforms
Introns
Mutation
Polyadenylation
8 Citations

Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome

Gong, Q., Stump, M. R. & Zhou, Z., Apr 15 2014, In : Gene. 539, 2, p. 190-197 8 p.

Research output: Contribution to journalArticle

Nonsense Mediated mRNA Decay
Long QT Syndrome
Nonsense Codon
Mutation
Exons
2 Citations
Morpholinos
Polyadenylation
Antisense Oligonucleotides
Introns
Protein Isoforms
2013
8 Citations
Long QT Syndrome
Nonsense Codon
Ether
Nonsense Mediated mRNA Decay
Genes
2012
12 Citations
Long QT Syndrome
Nonsense Codon
Ether
Genes
Nonsense Mediated mRNA Decay
6 Citations

Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome

Stump, M. R., Gong, Q. & Zhou, Z., Aug 2 2012, In : PLoS One. 7, 8, e42552

Research output: Contribution to journalArticle

Long QT Syndrome
Ether
ethers
Protein Isoforms
Genes
2011
20 Citations
Nonsense Mediated mRNA Decay
Long QT Syndrome
Morpholinos
Frameshift Mutation
Antisense Oligonucleotides
6 Citations
Long QT Syndrome
Ether
Mutation
Genes
RNA Splice Sites
17 Citations

Nonsense-mediated mRNA decay caused by a frameshift mutation in a large kindred of type 2 long QT syndrome

Zarraga, I. G., Zhang, L., Stump, M. R., Gong, Q., Vincent, G. M. & Zhou, Z., Aug 2011, In : Heart Rhythm. 8, 8, p. 1200-1206 7 p.

Research output: Contribution to journalArticle

Nonsense Mediated mRNA Decay
Long QT Syndrome
Frameshift Mutation
Nonsense Codon
RNA Stability
2010
11 Citations

Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms

Gong, Q., Stump, M. R., Dunn, A. R., Deng, V. & Zhou, Z., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32233-32241 9 p.

Research output: Contribution to journalArticle

Polyadenylation
Alternative Splicing
Ether
Protein Isoforms
Genes
36 Citations

A major role for hERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer

Hou, L., Deo, M., Furspan, P., Pandit, S. V., Mironov, S., Auerbach, D. S., Gong, Q., Zhou, Z., Berenfeld, O. & Jalife, J., Dec 10 2010, In : Circulation Research. 107, 12, p. 1503-1511 9 p.

Research output: Contribution to journalArticle

pamidronate
Ether
Muscle Cells
Up-Regulation
Action Potentials
2008
17 Citations

A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome

Gong, Q., Zhang, L., Moss, A. J., Vincent, G. M., Ackerman, M. J., Robinson, J. C., Jones, M. A., Tester, D. J. & Zhou, Z., Mar 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 502-509 8 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Ether
RNA Splice Sites
Mutation
Introns
38 Citations

Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation

Bhuiyan, Z. A., Momenah, T. S., Gong, Q., Amin, A. S., Ghamdi, S. A., Carvalho, J. S., Homfray, T., Mannens, M. M. A. M., Zhou, Z. & Wilde, A. A. M., Apr 2008, In : Heart Rhythm. 5, 4, p. 553-561 9 p.

Research output: Contribution to journalArticle

Cardiac Arrhythmias
Mutation
Ion Channels
Genes
Aptitude
2007
84 Citations

Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome

Gong, Q., Zhang, L., Vincent, G. M., Horne, B. D. & Zhou, Z., Jul 2007, In : Circulation. 116, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

Nonsense Mediated mRNA Decay
Long QT Syndrome
Nonsense Codon
Ether
Messenger RNA

The mechanistic rote of KCNH2 gene L413P and L559H mutations in long QT syndrome

Li, C. L., Hu, D. Y., Liu, W. L., Qi, S. Y., Wang, H. T., Li, L., Gong, Q. M. & Zhou, Z. F., Oct 2007, In : Zhonghua nei ke za zhi [Chinese journal of internal medicine]. 46, 10, p. 838-841 4 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Mutation
Genes
Mutant Proteins
Fluorescent Antibody Technique
2006
62 Citations

Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome

Gong, Q., Jones, M. A. & Zhou, Z., Feb 17 2006, In : Journal of Biological Chemistry. 281, 7, p. 4069-4074 6 p.

Research output: Contribution to journalArticle

Human Trafficking
Long QT Syndrome
Calnexin
Ether
Genes
273 Citations

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

Anderson, C. L., Delisle, B. P., Anson, B. D., Kilby, J. A., Will, M. L., Tester, D. J., Gong, Q., Zhou, Z., Ackerman, M. J. & January, C. T., Jan 2006, In : Circulation. 113, 3, p. 365-373 9 p.

Research output: Contribution to journalArticle

Ether
Phenotype
Mutation
Genes
Protein Transport
2005
79 Citations

Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway

Gong, Q., Keeney, D. R., Molinari, M. & Zhou, Z., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 19419-19425 7 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Proteasome Endopeptidase Complex
Ubiquitin
Ether
Endoplasmic Reticulum
2004
47 Citations

Defective assembly and trafficking of mutant HERG channels with C-terminal truncations in long QT syndrome

Gong, Q., Keeney, D. R., Robinson, J. C. & Zhou, Z., Dec 2004, In : Journal of Molecular and Cellular Cardiology. 37, 6, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

Human Trafficking
Long QT Syndrome
Ether
Genes
Mutation
38 Citations
Human Trafficking
Ether
Pharmacology
Endoplasmic Reticulum
Genes
137 Citations

Postmortem molecular screening in unexplained sudden death

Chugh, S. S., Senashova, O., Watts, A., Tran, P. T., Zhou, Z., Gong, Q., Titus, J. L. & Hayflick, S. J., May 5 2004, In : Journal of the American College of Cardiology. 43, 9, p. 1625-1629 5 p.

Research output: Contribution to journalArticle

Sudden Death
Sudden Cardiac Death
Autopsy
Genes
Cardiac Arrhythmias
2002
102 Citations
Potassium Channels
Glycosylation
Ether
Genes
Delayed Rectifier Potassium Channels
2001
61 Citations

Cocaine blocks HERG, but not KvLQT1+minK, potassium channels

Zhang, S., Rajamani, S., Chen, Y., Gong, Q., Rong, Y., Zhou, Z., Ruoho, A. & January, C. T., 2001, In : Molecular Pharmacology. 59, 5, p. 1069-1076 8 p.

Research output: Contribution to journalArticle

Mink
Potassium Channels
Cocaine
Sudden Death
Cardiac Arrhythmias
34 Citations

Differences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndrome

Studenik, C. R., Zhou, Z. & January, C. T., 2001, In : British Journal of Pharmacology. 132, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Action Potentials
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Muscle Cells
Pharmacology
2000
2 Citations

Defective protein trafficking of HERG K+ channels in human congenital long QT syndrome

January, C. T., Gong, Q. & Zhou, Z., 2000, In : Pharmaceutical News. 7, 4, p. 27-34 8 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Protein Transport
Mutation
Endoplasmic Reticulum
Proteolysis
3 Citations
Anti-Arrhythmia Agents
Action Potentials
Purkinje Fibers
Cardiac Glycosides
Microelectrodes
92 Citations

Long QT syndrome: Cellular basis and arrhythmia mechanism in LQT2

January, C. T., Gong, Q. & Zhou, Z., 2000, In : Journal of Cardiovascular Electrophysiology. 11, 12, p. 1413-1418 6 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Cardiac Arrhythmias
Ether
Mutation
Genes
1999
155 Citations

Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

Zhou, Z., Vorperian, V. R., Gong, Q., Zhang, S. & January, C. T., 1999, In : Journal of Cardiovascular Electrophysiology. 10, 6, p. 836-843 8 p.

Research output: Contribution to journalArticle

Astemizole
Histamine Antagonists
Potassium Channels
Ether
Genes
245 Citations
Long QT Syndrome
Potassium Channels
Protein Transport
Ether
Thermal effects
100 Citations

Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current

Drolet, B., Zhang, S., Deschênes, D., Rail, J., Nadeau, S., Zhou, Z., January, C. T. & Turgeon, J., 1999, In : Journal of Cardiovascular Electrophysiology. 10, 12, p. 1597-1604 8 p.

Research output: Contribution to journalArticle

Droperidol
Potassium
Guinea Pigs
Butyrophenones
Torsades de Pointes
276 Citations

Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

Zhang, S., Zhou, Z., Gong, Q., Makielski, J. C. & January, C. T., May 14 1999, In : Circulation Research. 84, 9, p. 989-998 10 p.

Research output: Contribution to journalArticle

Potassium Channels
Verapamil
Diltiazem
Nifedipine
Mutation
154 Citations

Novel mechanism associated with an inherited cardiac arrhythmia: Defective protein trafficking by the mutant HERG (G601S) potassium channel

Furutani, M., Trudeau, M. C., Hagiwara, N., Seki, A., Gong, Q., Zhou, Z., Imamura, S. I., Nagashima, H., Kasanuki, H., Takao, A., Momma, K., January, C. T., Robertson, G. A. & Matsuoka, R., May 4 1999, In : Circulation. 99, 17, p. 2290-2294 5 p.

Research output: Contribution to journalArticle

Potassium Channels
Protein Transport
Long QT Syndrome
Ether
Cardiac Arrhythmias
1998
51 Citations

Both T- and L-type Ca2+ channels can contribute to excitation- contraction coupling in cardiac Purkinje cells

Zhou, Z. & January, C. T., 1998, In : Biophysical Journal. 74, 4, p. 1830-1839 10 p.

Research output: Contribution to journalArticle

Excitation Contraction Coupling
Purkinje Cells
Sarcoplasmic Reticulum
Signal Transduction
Amphotericin B
291 Citations

HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects

Zhou, Z., Gong, Q., Epstein, M. L. & January, C. T., Aug 14 1998, In : Journal of Biological Chemistry. 273, 33, p. 21061-21066 6 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Defects
Mutation
Chromosomes
Processing
120 Citations

Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines

Taglialatela, M., Pannaccione, A., Castaldo, P., Giorgio, G., Zhou, Z., January, C. T., Genovese, A., Marone, G. & Annunziato, L., Jul 1998, In : Molecular Pharmacology. 54, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

Non-Sedating Histamine H1 Antagonists
Cetirizine
Histamine H1 Receptors
Ether
Genes
562 Citations

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

Zhou, Z., Gong, Q., Ye, B., Fan, Z., Makielski, J. C., Robertson, G. A. & January, C. T., Jan 1998, In : Biophysical Journal. 74, 1, p. 230-241 12 p.

Research output: Contribution to journalArticle

HEK293 Cells
Ether
Temperature
Genes
Action Potentials
1997
56 Citations
Cisapride
Gastrointestinal Agents
Ether
Genes
Tail
168 Citations
Cisapride
Gastrointestinal Agents
Ether
Genes
Tail
1996
99 Citations

Torsade de pointes with an antihistamine metabolite: Potassium channel blockade with desmethylastemizole

Vorperian, V. R., Zhou, Z., Mohammad, S., Hoon, T. J., Studenik, C. & January, C. T., Nov 15 1996, In : Journal of the American College of Cardiology. 28, 6, p. 1556-1561 6 p.

Research output: Contribution to journalArticle

Astemizole
Torsades de Pointes
Histamine Antagonists
Potassium Channels
Observation
1994
3 Citations

Delayed rectifier potassium current (IK) in latent atrial pacemaker cells isolated from cat right atrium

Zhou, Z. & Lipsius, S. L., Feb 1994, In : Pflügers Archiv European Journal of Physiology. 426, 3-4, p. 341-347 7 p.

Research output: Contribution to journalArticle

Pacemakers
Heart Atria
Potassium
Cats
Chemical activation
84 Citations

T-Type Calcium Current in Latent Pacemaker Cells Isolated from Cat Right Atrium

Zhou, Z. & Lipsius, S. L., Sep 1994, In : Journal of Molecular and Cellular Cardiology. 26, 9, p. 1211-1219 9 p.

Research output: Contribution to journalArticle

Heart Atria
Cats
Calcium
Muscle Cells
Patch-Clamp Techniques
1993
3 Citations

Cellular mechanisms of right atrial latent pacemakers

Lipsius, S. L., Rubenstein, D. S. & Zhou, Z., 1993, In : New Trends in Arrhythmias. 9, 1, p. 11-23 13 p.

Research output: Contribution to journalArticle

16 Citations
Pacemakers
Patch-Clamp Techniques
Heart Atria
Isoproterenol
Cats
80 Citations

Na+-Ca2+ exchange current in latent pacemaker cells isolated from cat right atrium

Zhou, Z. & Lipsius, S. L., 1993, In : Journal of Physiology. 466, p. 263-285 23 p.

Research output: Contribution to journalArticle

Heart Atria
Cats
Nystatin
Ryanodine
Isoproterenol
1992
31 Citations

Properties of the pacemaker current (I(f)) in latent pacemaker cells isolated from cat right atrium

Zhou, Z. & Lipsius, S. L., 1992, In : Journal of Physiology. 453, p. 503-523 21 p.

Research output: Contribution to journalArticle

Heart Atria
Cats
Cesium
Nystatin
Sinoatrial Node