• 6527 Citations
  • 47 h-Index
1984 …2020
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Research Output 1985 2018

  • 6527 Citations
  • 47 h-Index
  • 117 Article
  • 2 Conference contribution
  • 2 Editorial
  • 2 Review article
2018

Fractal regulation and incident Alzheimer's disease in elderly individuals

Li, P., Yu, L., Lim, A. S. P., Buchman, A. S., Scheer, F. A. J. L., Shea, S. A., Schneider, J. A., Bennett, D. A. & Hu, K., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Fractals
Alzheimer Disease
Motor Activity
Sleep Deprivation
Cognition

Lowest perceived exertion in the late morning due to effects of the endogenous circadian system

Thosar, S. S., Herzig, M. X., Roberts, S. A., Berman, A. M., Clemons, N. A., McHill, A. W., Bowles, N. P., Morimoto, M., Butler, M. P., Emens, J. S. & Shea, S. A., Feb 23 2018, (Accepted/In press) In : British Journal of Sports Medicine.

Research output: Contribution to journalArticle

Predictors of obtaining polysomnography among otolaryngologists prior to adenotonsillectomy for childhood sleep-disordered breathing

Lam, D. J., Shea, S. A., Weaver, E. M. & Mitchell, R. B., Aug 15 2018, In : Journal of Clinical Sleep Medicine. 14, 8, p. 1361-1367 7 p.

Research output: Contribution to journalArticle

Polysomnography
Sleep Apnea Syndromes
Otolaryngology
Neck
Head
1 Citations

Role of the circadian system in cardiovascular disease

Thosar, S. S., Butler, M. P. & Shea, S. A., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2157-2167 11 p.

Research output: Contribution to journalReview article

Circadian Rhythm
Cardiovascular Diseases
Activity Cycles
Circadian Clocks
Autonomic Nervous System

The importance of the circadian system & sleep for bone health

Swanson, C. M., Kohrt, W. M., Buxton, O. M., Everson, C. A., Wright, K. P., Orwoll, E. S. & Shea, S. A., Jan 1 2018, (Accepted/In press) In : Metabolism: Clinical and Experimental.

Research output: Contribution to journalArticle

Sleep
Bone and Bones
Health
Biological Phenomena
Circadian Clocks
2017
2 Citations

24-hour profile of serum sclerostin and its association with bone biomarkers in men

Swanson, C., Shea, S. A., Wolfe, P., Markwardt, S., Cain, S. W., Munch, M., Czeisler, C. A., Orwoll, E. S. & Buxton, O. M., Jul 26 2017, (Accepted/In press) In : Osteoporosis International. p. 1-9 9 p.

Research output: Contribution to journalArticle

Osteocytes
Periodicity
Bone Remodeling
Biomarkers
Bone and Bones
5 Citations

Bone Turnover Markers After Sleep Restriction and Circadian Disruption: A Mechanism for Sleep-Related Bone Loss in Humans

Swanson, C. M., Shea, S. A., Wolfe, P., Cain, S. W., Munch, M., Vujovic, N., Czeisler, C. A., Buxton, O. M. & Orwoll, E. S., Oct 1 2017, In : The Journal of clinical endocrinology and metabolism. 102, 10, p. 3722-3730 9 p.

Research output: Contribution to journalArticle

Bone Remodeling
Sleep
Bone
Bone and Bones
Biomarkers

Recent legalization of cannabis use: Effects on sleep, health, and workplace safety

Bowles, N. P., Herzig, M. X. & Shea, S. A., Jan 1 2017, In : Nature and Science of Sleep. 9, p. 249-251 3 p.

Research output: Contribution to journalEditorial

Cannabis
Workplace
Sleep
Safety
Health
2016

A growth spurt in pediatric sleep research

Lam, D. J. & Shea, S. A., 2016, In : Nature and Science of Sleep. 8, p. 133-135 3 p.

Research output: Contribution to journalReview article

Sleep
Pediatrics
Growth
Research

Are we underestimating the lifelong benefits of therapy for obstructive sleep apnea?

Berman, A. M., Thosar, S. S. & Shea, S. A., 2016, In : Nature and Science of Sleep. 8, p. 87-89 3 p.

Research output: Contribution to journalEditorial

Obstructive Sleep Apnea
Therapeutics
8 Citations

Assessment of pediatric obstructive sleep apnea using a drug-induced sleep endoscopy rating scale

Lam, D. J., Weaver, E. M., Macarthur, C. J., Milczuk, H. A., O'Neill, E., Smith, T. L., Nguyen, T. & Shea, S. A., 2016, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Obstructive Sleep Apnea
Endoscopy
Sleep
Pediatrics
Pharmaceutical Preparations
1 Citations

ATS core curriculum 2016: Part I. adult sleep medicine

Balachandran, J. S., Thomson, C. C., Sumter, D. B., Shelgikar, A. V., Lachapelle, P., Pamidi, S., Fall, M., Lal, C., Baba, R. Y., Shah, N., Fields, B. G., Sarmiento, K., Butler, M. P., Shea, S. A., Baptiste, J. V., Sharkey, K. M. & Wang, T., Apr 1 2016, In : Annals of the American Thoracic Society. 13, 4, p. 549-561 13 p.

Research output: Contribution to journalArticle

Chronobiology Disorders
Circadian Rhythm Sleep Disorders
Parasomnias
Polysomnography
Medical Societies
6 Citations

Circadian gene variants influence sleep and the sleep electroencephalogram in humans

Chang, A. M., Bjonnes, A. C., Aeschbach, D., Buxton, O. M., Gooley, J. J., Anderson, C., Van Reen, E., Cain, S. W., Czeisler, C. A., Duffy, J. F., Lockley, S. W., Shea, S. A., Scheer, F. A. J. L. & Saxena, R., May 27 2016, In : Chronobiology International. 33, 5, p. 561-573 13 p.

Research output: Contribution to journalArticle

Electroencephalography
Sleep
Genes
REM Sleep
Melatonin MT2 Receptor
20 Citations

Impact of common diabetes risk variant in MTNR1B on sleep, circadian, and melatonin physiology

Lane, J. M. , Chang, A. M. , Bjonnes, A. C. , Aeschbach, D. , Anderson, C. , Cade, B. E. , Cain, S. W. , Czeisler, C. A. , Gharib, S. A. , Gooley, J. J. , Gottlieb, D. J. , Grant, S. F. A. , Klerman, E. B. , Lauderdale, D. S. , Lockley, S. W. , Munch, M. , Patel, S. , Punjabi, N. M. , Rajaratnam, S. M. W. , Rueger, M. & 11 others St. Hilaire, M. A., Santhi, N., Scheuermaier, K., Van Reen, E., Zee, P. C., Shea, S. A., Duffy, J. F., Buxton, O. M., Redline, S., Scheer, F. A. J. L. & Saxena, R., Jun 1 2016, In : Diabetes. 65, 6, p. 1741-1751 11 p.

Research output: Contribution to journalArticle

Melatonin
Sleep
Alleles
Actigraphy
Type 2 Diabetes Mellitus
5 Citations

Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results from a 3.5-Year, Longitudinal Randomized Controlled Trial

Hu, K., Riemersma-Van Der Lek, R. F., Patxot, M., Li, P., Shea, S. A., Scheer, F. A. J. L. & Van Someren, E. J. W., Jun 13 2016, In : Scientific Reports. 6, 27742

Research output: Contribution to journalArticle

Dementia
Randomized Controlled Trials
Exercise
Melatonin
Depression
2015

Brachial artery endothelial function is stable across the morning in young men

Thosar, S. S., Wiggins, C. C., Shea, S. A. & Wallace, J. P., Dec 1 2015, In : Cardiovascular Ultrasound. 13, 1, 36

Research output: Contribution to journalArticle

Brachial Artery
Blood Vessels
Circadian Rhythm
Dilatation
Sleep
22 Citations

Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans

Rahman, S. A., Castanon-Cervantes, O., Scheer, F. A. J. L., Shea, S. A., Czeisler, C. A., Davidson, A. J. & Lockley, S. W., Jul 1 2015, In : Brain, Behavior, and Immunity. 47, p. 4-13 10 p.

Research output: Contribution to journalArticle

Chemokines
Lipopolysaccharides
Immunologic Factors
Cytokines
Sleep
83 Citations

Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans

Morris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A. & Scheer, F. A. J. L., Apr 28 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 17, p. E2225-E2234

Research output: Contribution to journalArticle

Glucose
Insulin
Sleep
Insulin-Secreting Cells
Insulin Resistance
25 Citations

Obstructive sleep apnea and metabolic bone disease: Insights into the relationship between bone and sleep

Swanson, C. M., Shea, S. A., Stone, K. L., Cauley, J. A., Rosen, C. J., Redline, S., Karsenty, G. & Orwoll, E. S., Feb 1 2015, In : Journal of Bone and Mineral Research. 30, 2, p. 199-211 13 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Obstructive Sleep Apnea
Sleep
Bone and Bones
Sleep Apnea Syndromes
11 Citations

The circadian system contributes to apnea lengthening across the night in obstructive sleep apnea

Butler, M. P., Smales, C., Wu, H., Hussain, M. V., Mohamed, Y. A., Morimoto, M. & Shea, S. A., Nov 1 2015, In : Sleep. 38, 11, p. 1793-1801 9 p.

Research output: Contribution to journalArticle

Obstructive Sleep Apnea
Apnea
Sleep
Sleep Apnea Syndromes
Inpatients
2014
42 Citations

Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle

Scheer, F. A. J. L. & Shea, S. A., Jan 23 2014, In : Blood. 123, 4, p. 590-593 4 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Sleep
Exercise
Fibrinolysis
Circadian Rhythm
12 Citations

Simulated shift work in rats perturbs multiscale regulation of locomotor activity

Hsieh, W. H., Escobar, C., Yugay, T., Lo, M. T., Pittman-Polletta, B., Salgado-Delgado, R., Scheer, F. A. J. L., Shea, S. A., Buijs, R. M. & Hu, K., Jul 6 2014, In : Journal of the Royal Society Interface. 11, 96, 20140318

Research output: Contribution to journalArticle

Locomotion
Fractals
Suprachiasmatic Nucleus
Rats
Animals
2013
21 Citations

Evaluation of a single-channel nasal pressure device to assess obstructive sleep apnea risk in laboratory and home environments

Crowley, K. E., Rajaratnam, S. M. W., Shea, S. A., Epstein, L. J., Czeisler, C. A. & Lockley, S. W., 2013, In : Journal of Clinical Sleep Medicine. 9, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

Obstructive Sleep Apnea
Apnea
Nose
Pressure
Equipment and Supplies
20 Citations

Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia

Hu, K., Harper, D. G., Shea, S. A., Stopa, E. G. & Scheer, F. A. J. L., Jul 18 2013, In : Scientific Reports. 3, 2229

Research output: Contribution to journalArticle

Fractals
Neurotransmitter Agents
Dementia
Biomarkers
Suprachiasmatic Nucleus
51 Citations

The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors

Scheer, F. A. J. L., Morris, C. J. & Shea, S. A., Mar 2013, In : Obesity. 21, 3, p. 421-423 3 p.

Research output: Contribution to journalArticle

Circadian Clocks
Hunger
Appetite
Sleep
Eating
23 Citations

The role of the circadian system in fractal neurophysiological control

Pittman-Polletta, B. R., Scheer, F. A. J. L., Butler, M. P., Shea, S. A. & Hu, K., Nov 2013, In : Biological Reviews. 88, 4, p. 873-894 22 p.

Research output: Contribution to journalArticle

Fractals
heart rate
physiology
health information
neurophysiology
2012
298 Citations

Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption

Buxton, O. M., Cain, S. W., O'Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A. & Shea, S. A., Apr 11 2012, In : Science Translational Medicine. 4, 129, 129ra43

Research output: Contribution to journalArticle

Sleep
Glucose
Basal Metabolism
Meals
Epidemiologic Studies
156 Citations

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

Jeyaraj, D. , Haldar, S. M. , Wan, X. , McCauley, M. D. , Ripperger, J. A. , Hu, K. , Lu, Y. , Eapen, B. L. , Sharma, N. , Ficker, E. , Cutler, M. J. , Gulick, J. , Sanbe, A. , Robbins, J. , Demolombe, S. , Kondratov, R. V. , Shea, S. A. , Albrecht, U. , Wehrens, X. H. T. , Rosenbaum, D. S. & 1 others Jain, M. K., Mar 1 2012, In : Nature. 483, 7387, p. 96-101 6 p.

Research output: Contribution to journalArticle

Kruppel-Like Transcription Factors
Circadian Rhythm
Cardiac Arrhythmias
Ion Channels
Kv Channel-Interacting Proteins
23 Citations

Fractal Patterns of Neural Activity Exist within the Suprachiasmatic Nucleus and Require Extrinsic Network Interactions

Hu, K., Meijer, J. H., Shea, S. A., vanderLeest, H. T., Pittman-Polletta, B., Houben, T., van Oosterhout, F., Deboer, T. & Scheer, F. A. J. L., 2012, In : PLoS One. 7, 11, e48927

Research output: Contribution to journalArticle

Fractals
Suprachiasmatic Nucleus
heart rate
neural networks
rodents
46 Citations

Klf15 orchestrates circadian nitrogen homeostasis

Jeyaraj, D. , Scheer, F. A. J. L. , Ripperger, J. A. , Haldar, S. M. , Lu, Y. , Prosdocimo, D. A. , Eapen, S. J. , Eapen, B. L. , Cui, Y. , Mahabeleshwar, G. H. , Lee, H. G. , Smith, M. A. , Casadesus, G. , Mintz, E. M. , Sun, H. , Wang, Y. , Ramsey, K. M. , Bass, J. , Shea, S. A. , Albrecht, U. & 1 others Jain, M. K., Mar 7 2012, In : Cell Metabolism. 15, 3, p. 311-323 13 p.

Research output: Contribution to journalArticle

Homeostasis
Nitrogen
Kruppel-Like Transcription Factors
Periodicity
Cues
12 Citations

Obesity and pharmacologic control of the body clock

Shea, S. A., Jul 12 2012, In : New England Journal of Medicine. 367, 2, p. 175-178 4 p.

Research output: Contribution to journalArticle

Obesity
30 Citations

Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: A randomized controlled trial

Scheer, F. A. J. L., Morris, C. J., Garcia, J. I., Smales, C., Kelly, E. E., Marks, J., Malhotra, A. & Shea, S. A., Oct 1 2012, In : Sleep. 35, 10, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

Melatonin
Sleep
Randomized Controlled Trials
Placebos
Sleep Stages
2011
35 Citations

Endogenous circadian rhythm in vasovagal response to head-up tilt

Hu, K., Scheer, F. A. J. L., Laker, M., Smales, C. & Shea, S. A., Mar 8 2011, In : Circulation. 123, 9, p. 961-970 10 p.

Research output: Contribution to journalArticle

Syncope
Circadian Rhythm
Head
Cardiovascular System
Sleep
59 Citations

Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening

Shea, S. A., Hilton, M. F., Hu, K. & Scheer, F. A. J. L., Apr 15 2011, In : Circulation Research. 108, 8, p. 980-984 5 p.

Research output: Contribution to journalArticle

Blood Pressure
Sleep
Circadian Rhythm
Wakefulness
Body Temperature

Health disparities in sleep medicine: Responses to the American Sleep Medicine Foundation humanitarian projects award program

Wise, M. S., Morgenthaler, T., Badr, S., Gruber, R., Redline, S. & Shea, S. A., 2011, In : Journal of Clinical Sleep Medicine. 7, 6, p. 583-584 2 p.

Research output: Contribution to journalArticle

Sleep Medicine Specialty
Healthcare Disparities
Altruism
Program Development
Medical Societies

Response to letter regarding article, endogenous circadian rhythm in vasovagal response to head-up tilt

Hu, K., Scheer, F. A. J. L., Shea, S. A., Laker, M. & Smales, C., Sep 27 2011, In : Circulation. 124, 13

Research output: Contribution to journalArticle

124 Citations

Sleep disorders, health, and safety in police officers

Rajaratnam, S. M. W., Barger, L. K., Lockley, S. W., Shea, S. A., Wang, W., Landrigan, C. P., O'Brien, C. S., Qadri, S., Sullivan, J. P., Cade, B. E., Epstein, L. J., White, D. P. & Czeisler, C. A., Dec 21 2011, In : JAMA - Journal of the American Medical Association. 306, 23, p. 2567-2578 12 p.

Research output: Contribution to journalArticle

Police
Safety
Odds Ratio
Health
Obstructive Sleep Apnea
59 Citations

The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors

Scheer, F. A. J. L., Michelson, A. D., Frelinger, A. L., Evoniuk, H., Kelly, E. E., McCarthy, M., Doamekpor, L. A., Barnard, M. R. & Shea, S. A., Sep 8 2011, In : PLoS One. 6, 9, e24549

Research output: Contribution to journalArticle

platelet activation
Platelet Activation
Platelets
circadian rhythm
Blood Platelets

The nature of sleep examined via the science of sleep

Hussain, M. V. & Shea, S. A., 2011, In : Nature and Science of Sleep. 3, p. 37-38 2 p.

Research output: Contribution to journalArticle

Sleep
3 Citations

Wake up to insomnia: Future approaches to the management of insomnia

Hussain, M. T. & Shea, S. A., 2011, In : Nature and Science of Sleep. 3, p. 33-35 3 p.

Research output: Contribution to journalArticle

Sleep Initiation and Maintenance Disorders
2010
40 Citations

Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions

Scheer, F. A. J. L., Chan, J. L., Fargnoli, J., Chamberland, J., Arampatzi, K., Shea, S. A., Blackburn, G. L. & Mantzoros, C. S., Nov 2010, In : Diabetologia. 53, 11, p. 2401-2405 5 p.

Research output: Contribution to journalArticle

Adiponectin
Molecular Weight
Sleep
Fasting
Leptin Receptors
120 Citations

Impact of the human circadian system, exercise, and their interaction on cardiovascular function

Scheer, F. A. J. L., Hu, K., Evoniuk, H., Kelly, E. E., Malhotra, A., Hilton, M. F. & Shea, S. A., Nov 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 47, p. 20541-20546 6 p.

Research output: Contribution to journalArticle

Exercise
Catecholamines
Hemostatics
Hemostasis
Epinephrine
2009
857 Citations

Adverse metabolic and cardiovascular consequences of circadian misalignment

Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S. & Shea, S. A., Mar 17 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4453-4458 6 p.

Research output: Contribution to journalArticle

Sleep
Leptin
Glucose
Hydrocortisone
Obesity
40 Citations

Influence of the Circadian System on Disease Severity

Litinski, M., Scheer, F. A. J. L. & Shea, S. A., Jun 2009, In : Sleep Medicine Clinics. 4, 2, p. 143-163 21 p.

Research output: Contribution to journalArticle

Chronotherapy
Circadian Clocks
Temporal Lobe
Circadian Rhythm
Epilepsy
28 Citations

Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?

Pavlova, M. K., Shea, S. A., Scheer, F. A. J. L. & Bromfield, E. B., Nov 2009, In : Epilepsy and Behavior. 16, 3, p. 461-467 7 p.

Research output: Contribution to journalArticle

Sleep
Generalized Epilepsy
Melatonin
Consciousness
Electroencephalography
79 Citations

Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker

Hu, K., Van Someren, E. J. W., Shea, S. A. & Scheer, F. A. J. L., Feb 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 8, p. 2490-2494 5 p.

Research output: Contribution to journalArticle

Suprachiasmatic Nucleus
Alzheimer Disease
Young Adult
2008
64 Citations

An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night

Scheer, F. A. J. L., Shea, T. J., Hilton, M. F. & Shea, S. A., Aug 2008, In : Journal of Biological Rhythms. 23, 4, p. 353-361 9 p.

Research output: Contribution to journalArticle

Circadian Rhythm
sleep
circadian rhythm
Sleep
Sleep Stages
69 Citations

Polysomnographic respiratory abnormalities in asymptomatic individuals

Pavlova, M. K., Duffy, J. F. & Shea, S. A., 2008, In : Sleep. 31, 2, p. 241-248 8 p.

Research output: Contribution to journalArticle

Healthy Volunteers
Sleep
Polysomnography
Physical Examination
Electrocardiography
18 Citations

The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats

Hu, K., Scheer, F. A. J. L., Buijs, R. M. & Shea, S. A., Oct 2008, In : Cardiovascular Research. 80, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

Fractals
Circadian Rhythm
Suprachiasmatic Nucleus
Heart Rate
Activity Cycles
26 Citations

The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours

Hu, K., Scheer, F. A. J. L., Buijs, R. M. & Shea, S. A., Jun 2008, In : Journal of Biological Rhythms. 23, 3, p. 265-273 9 p.

Research output: Contribution to journalArticle

physical models
cardiovascular diseases
heart rate
Heart Rate
mammals