• 7793 Citations
  • 49 h-Index
1984 …2020

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Article
2020

Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis

Butler, M. P., Thosar, S. S., Smales, C., DeYoung, P. N., Wu, H., Hussain, M. V., Morimoto, M., Hu, K., Scheer, F. A. J. L. & Shea, S. A., Jan 1 2020, (Accepted/In press) In : Chronobiology International.

Research output: Contribution to journalArticle

Sleep-Wake Disturbances After Acquired Brain Injury in Children Surviving Critical Care

Williams, C. N., Hartman, M. E., McEvoy, C. T., Hall, T. A., Lim, M. M., Shea, S. A., Luther, M., Guilliams, K. P., Guerriero, R. M., Bosworth, C. C. & Piantino, J. A., Feb 2020, In : Pediatric Neurology. 103, p. 43-51 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans

Qian, J., Scheer, F. A., Hu, K. & Shea, S. A., Apr 15 2020, In : Sleep. 43, 4

Research output: Contribution to journalArticle

2019

Apnea-hypopnea event duration predicts mortality in men and women in the sleep heart health study

Butler, M. P., Emch, J. T., Rueschman, M., Sands, S. A., Shea, S. A., Wellman, A. & Redline, S., Apr 1 2019, In : American journal of respiratory and critical care medicine. 199, 7, p. 903-912 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Circadian Rhythm of Vascular Function in Midlife Adults

Thosar, S. S., Berman, A. M., Herzig, M. X., McHill, A. W., Bowles, N. P., Swanson, C. M., Clemons, N. A., Butler, M., Clemons, A. A., Emens, J. & Shea, S., Jun 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 6, p. 1203-1211 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Impact of mental stress, the circadian system and their interaction on human cardiovascular function

Scheer, F. A. J. L., Chellappa, S. L., Hu, K. & Shea, S. A., May 2019, In : Psychoneuroendocrinology. 103, p. 125-129 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Rapid suppression of bone formation marker in response to sleep restriction and circadian disruption in men

Swanson, C. M., Kohrt, W. M., Wolfe, P., Wright, K. P., Shea, S. A., Cain, S. W., Munch, M., Vujović, N., Czeisler, C. A., Orwoll, E. S. & Buxton, O. M., Dec 1 2019, In : Osteoporosis International. 30, 12, p. 2485-2493 9 p.

Research output: Contribution to journalArticle

Separate and interacting effects of the endogenous circadian system and behaviors on plasma aldosterone in humans

Thosar, S. S., Rueda, J., Berman, A. M., Lasarev, M. R., Herzig, M. X., Clemons, N. A., Roberts, S. A., Bowles, N. P., Emens, J., Ellison, D. & Shea, S., Feb 1 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 2, p. R157-R164

Research output: Contribution to journalArticle

1 Scopus citations
2018

Fractal regulation and incident Alzheimer's disease in elderly individuals

Li, P., Yu, L., Lim, A. S. P., Buchman, A. S., Scheer, F. A. J. L., Shea, S., Schneider, J. A., Bennett, D. A. & Hu, K., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

8 Scopus citations

Morning impairment in vascular function is unrelated to overnight sleep or the inactivity that accompanies sleep

Thosar, S. S., Berman, A. M., Herzig, M. X., Roberts, S. A., Lasarev, M. R. & Shea, S., Nov 27 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315, 5, p. R986-R993

Research output: Contribution to journalArticle

3 Scopus citations

Predictors of obtaining polysomnography among otolaryngologists prior to adenotonsillectomy for childhood sleep-disordered breathing

Lam, D. J., Shea, S. A., Weaver, E. M. & Mitchell, R. B., Aug 15 2018, In : Journal of Clinical Sleep Medicine. 14, 8, p. 1361-1367 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

The importance of the circadian system & sleep for bone health

Swanson, C. M., Kohrt, W. M., Buxton, O. M., Everson, C. A., Wright, K. P., Orwoll, E. S. & Shea, S. A., Jul 2018, In : Metabolism: Clinical and Experimental. 84, p. 28-43 16 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

24-hour profile of serum sclerostin and its association with bone biomarkers in men

Swanson, C., Shea, S. A., Wolfe, P., Markwardt, S., Cain, S. W., Munch, M., Czeisler, C. A., Orwoll, E. S. & Buxton, O. M., Nov 1 2017, In : Osteoporosis International. 28, 11, p. 3205-3213 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Bone turnover markers after sleep restriction and circadian disruption: A mechanism for sleep-related bone loss in humans

Swanson, C. M., Shea, S. A., Wolfe, P., Cain, S. W., Munch, M., Vujović, N., Czeisler, C. A., Buxton, O. M. & Orwoll, E. S., Oct 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 10, p. 3722-3730 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Assessment of pediatric obstructive sleep apnea using a drug-induced sleep endoscopy rating scale

Lam, D., Weaver, E. M., Macarthur, C., Milczuk, H., O'Neill, E., Smith, T., Nguyen, T. & Shea, S., 2016, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

16 Scopus citations

ATS core curriculum 2016: Part I. adult sleep medicine

Balachandran, J. S., Thomson, C. C., Sumter, D. B., Shelgikar, A. V., Lachapelle, P., Pamidi, S., Fall, M., Lal, C., Baba, R. Y., Shah, N., Fields, B. G., Sarmiento, K., Butler, M., Shea, S., Baptiste, J. V., Sharkey, K. M. & Wang, T., Apr 1 2016, In : Annals of the American Thoracic Society. 13, 4, p. 549-561 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Circadian gene variants influence sleep and the sleep electroencephalogram in humans

Chang, A. M., Bjonnes, A. C., Aeschbach, D., Buxton, O. M., Gooley, J. J., Anderson, C., Van Reen, E., Cain, S. W., Czeisler, C. A., Duffy, J. F., Lockley, S. W., Shea, S. A., Scheer, F. A. J. L. & Saxena, R., May 27 2016, In : Chronobiology International. 33, 5, p. 561-573 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Impact of common diabetes risk variant in MTNR1B on sleep, circadian, and melatonin physiology

Lane, J. M., Chang, A. M., Bjonnes, A. C., Aeschbach, D., Anderson, C., Cade, B. E., Cain, S. W., Czeisler, C. A., Gharib, S. A., Gooley, J. J., Gottlieb, D. J., Grant, S. F. A., Klerman, E. B., Lauderdale, D. S., Lockley, S. W., Munch, M., Patel, S., Punjabi, N. M., Rajaratnam, S. M. W., Rueger, M. & 11 others, St. Hilaire, M. A., Santhi, N., Scheuermaier, K., Van Reen, E., Zee, P. C., Shea, S. A., Duffy, J. F., Buxton, O. M., Redline, S., Scheer, F. A. J. L. & Saxena, R., Jun 1 2016, In : Diabetes. 65, 6, p. 1741-1751 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results from a 3.5-Year, Longitudinal Randomized Controlled Trial

Hu, K., Riemersma-Van Der Lek, R. F., Patxot, M., Li, P., Shea, S. A., Scheer, F. A. J. L. & Van Someren, E. J. W., Jun 13 2016, In : Scientific Reports. 6, 27742.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Brachial artery endothelial function is stable across the morning in young men

Thosar, S. S., Wiggins, C. C., Shea, S. A. & Wallace, J. P., Dec 1 2015, In : Cardiovascular Ultrasound. 13, 1, 36.

Research output: Contribution to journalArticle

1 Scopus citations

Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans

Rahman, S. A., Castanon-Cervantes, O., Scheer, F. A. J. L., Shea, S. A., Czeisler, C. A., Davidson, A. J. & Lockley, S. W., Jul 1 2015, In : Brain, Behavior, and Immunity. 47, p. 4-13 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans

Morris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A. & Scheer, F. A. J. L., Apr 28 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 17, p. E2225-E2234

Research output: Contribution to journalArticle

139 Scopus citations

The circadian system contributes to apnea lengthening across the night in obstructive sleep apnea

Butler, M. P., Smales, C., Wu, H., Hussain, M. V., Mohamed, Y. A., Morimoto, M. & Shea, S. A., Nov 1 2015, In : Sleep. 38, 11, p. 1793-1801 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle

Scheer, F. A. J. L. & Shea, S. A., Jan 23 2014, In : Blood. 123, 4, p. 590-593 4 p.

Research output: Contribution to journalArticle

67 Scopus citations

Simulated shift work in rats perturbs multiscale regulation of locomotor activity

Hsieh, W. H., Escobar, C., Yugay, T., Lo, M. T., Pittman-Polletta, B., Salgado-Delgado, R., Scheer, F. A. J. L., Shea, S. A., Buijs, R. M. & Hu, K., Jul 6 2014, In : Journal of the Royal Society Interface. 11, 96, 20140318.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Evaluation of a single-channel nasal pressure device to assess obstructive sleep apnea risk in laboratory and home environments

Crowley, K. E., Rajaratnam, S. M. W., Shea, S. A., Epstein, L. J., Czeisler, C. A. & Lockley, S. W., Feb 25 2013, In : Journal of Clinical Sleep Medicine. 9, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia

Hu, K., Harper, D. G., Shea, S. A., Stopa, E. G. & Scheer, F. A. J. L., Jul 18 2013, In : Scientific Reports. 3, 2229.

Research output: Contribution to journalArticle

30 Scopus citations

The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors

Scheer, F. A. J. L., Morris, C. J. & Shea, S. A., Mar 1 2013, In : Obesity. 21, 3, p. 421-423 3 p.

Research output: Contribution to journalArticle

85 Scopus citations

The role of the circadian system in fractal neurophysiological control

Pittman-Polletta, B. R., Scheer, F. A. J. L., Butler, M. P., Shea, S. A. & Hu, K., Nov 1 2013, In : Biological Reviews. 88, 4, p. 873-894 22 p.

Research output: Contribution to journalArticle

32 Scopus citations
2012

Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption

Buxton, O. M., Cain, S. W., O'Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A. & Shea, S. A., Apr 11 2012, In : Science translational medicine. 4, 129, 129ra43.

Research output: Contribution to journalArticle

386 Scopus citations

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

Jeyaraj, D., Haldar, S. M., Wan, X., McCauley, M. D., Ripperger, J. A., Hu, K., Lu, Y., Eapen, B. L., Sharma, N., Ficker, E., Cutler, M. J., Gulick, J., Sanbe, A., Robbins, J., Demolombe, S., Kondratov, R. V., Shea, S. A., Albrecht, U., Wehrens, X. H. T., Rosenbaum, D. S. & 1 others, Jain, M. K., Mar 1 2012, In : Nature. 483, 7387, p. 96-101 6 p.

Research output: Contribution to journalArticle

190 Scopus citations

Fractal Patterns of Neural Activity Exist within the Suprachiasmatic Nucleus and Require Extrinsic Network Interactions

Hu, K., Meijer, J. H., Shea, S. A., vanderLeest, H. T., Pittman-Polletta, B., Houben, T., van Oosterhout, F., Deboer, T. & Scheer, F. A. J. L., Nov 27 2012, In : PloS one. 7, 11, e48927.

Research output: Contribution to journalArticle

27 Scopus citations

Klf15 orchestrates circadian nitrogen homeostasis

Jeyaraj, D., Scheer, F. A. J. L., Ripperger, J. A., Haldar, S. M., Lu, Y., Prosdocimo, D. A., Eapen, S. J., Eapen, B. L., Cui, Y., Mahabeleshwar, G. H., Lee, H. G., Smith, M. A., Casadesus, G., Mintz, E. M., Sun, H., Wang, Y., Ramsey, K. M., Bass, J., Shea, S. A., Albrecht, U. & 1 others, Jain, M. K., Mar 7 2012, In : Cell Metabolism. 15, 3, p. 311-323 13 p.

Research output: Contribution to journalArticle

66 Scopus citations

Obesity and pharmacologic control of the body clock

Shea, S. A., Jul 12 2012, In : New England Journal of Medicine. 367, 2, p. 175-178 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: A randomized controlled trial

Scheer, F. A. J. L., Morris, C. J., Garcia, J. I., Smales, C., Kelly, E. E., Marks, J., Malhotra, A. & Shea, S. A., Oct 1 2012, In : Sleep. 35, 10, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
2011

Endogenous circadian rhythm in vasovagal response to head-up tilt

Hu, K., Scheer, F. A. J. L., Laker, M., Smales, C. & Shea, S. A., Mar 8 2011, In : Circulation. 123, 9, p. 961-970 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening

Shea, S. A., Hilton, M. F., Hu, K. & Scheer, F. A. J. L., Apr 15 2011, In : Circulation research. 108, 8, p. 980-984 5 p.

Research output: Contribution to journalArticle

79 Scopus citations

Sleep disorders, health, and safety in police officers

Rajaratnam, S. M. W., Barger, L. K., Lockley, S. W., Shea, S. A., Wang, W., Landrigan, C. P., O'Brien, C. S., Qadri, S., Sullivan, J. P., Cade, B. E., Epstein, L. J., White, D. P. & Czeisler, C. A., Dec 21 2011, In : JAMA - Journal of the American Medical Association. 306, 23, p. 2567-2578 12 p.

Research output: Contribution to journalArticle

166 Scopus citations

The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors

Scheer, F. A. J. L., Michelson, A. D., Frelinger, A. L., Evoniuk, H., Kelly, E. E., McCarthy, M., Doamekpor, L. A., Barnard, M. R. & Shea, S. A., Sep 8 2011, In : PloS one. 6, 9, e24549.

Research output: Contribution to journalArticle

90 Scopus citations
2010

Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions

Scheer, F. A. J. L., Chan, J. L., Fargnoli, J., Chamberland, J., Arampatzi, K., Shea, S. A., Blackburn, G. L. & Mantzoros, C. S., Nov 1 2010, In : Diabetologia. 53, 11, p. 2401-2405 5 p.

Research output: Contribution to journalArticle

44 Scopus citations

Impact of the human circadian system, exercise, and their interaction on cardiovascular function

Scheer, F. A. J. L., Hu, K., Evoniuk, H., Kelly, E. E., Malhotra, A., Hilton, M. F. & Shea, S. A., Nov 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 47, p. 20541-20546 6 p.

Research output: Contribution to journalArticle

148 Scopus citations
2009

Adverse metabolic and cardiovascular consequences of circadian misalignment

Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S. & Shea, S. A., Mar 17 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4453-4458 6 p.

Research output: Contribution to journalArticle

1079 Scopus citations

Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?

Pavlova, M. K., Shea, S. A., Scheer, F. A. J. L. & Bromfield, E. B., Nov 1 2009, In : Epilepsy and Behavior. 16, 3, p. 461-467 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker

Hu, K., Van Someren, E. J. W., Shea, S. A. & Scheer, F. A. J. L., Feb 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 8, p. 2490-2494 5 p.

Research output: Contribution to journalArticle

97 Scopus citations
2008

An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night

Scheer, F. A. J. L., Shea, T. J., Hilton, M. F. & Shea, S. A., Aug 1 2008, In : Journal of biological rhythms. 23, 4, p. 353-361 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Polysomnographic respiratory abnormalities in asymptomatic individuals

Pavlova, M. K., Duffy, J. F. & Shea, S. A., Jan 1 2008, In : Sleep. 31, 2, p. 241-248 8 p.

Research output: Contribution to journalArticle

Open Access
72 Scopus citations

The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats

Hu, K., Scheer, F. A. J. L., Buijs, R. M. & Shea, S. A., Oct 1 2008, In : Cardiovascular research. 80, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours

Hu, K., Scheer, F. A. J. L., Buijs, R. M. & Shea, S. A., Jun 1 2008, In : Journal of biological rhythms. 23, 3, p. 265-273 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
2007

Endogenous circadian rhythm in human motor activity uncoupled from circadian influences on cardiac dynamics

Ivanov, P. C., Hu, K., Hilton, M. F., Shea, S. A. & Stanley, H. E., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20702-20707 6 p.

Research output: Contribution to journalArticle

74 Scopus citations

The suprachiasmatic nucleus functions beyond circadian rhythm generation

Hu, K., Scheer, F. A. J. L., Ivanov, P. C., Buijs, R. M. & Shea, S. A., Nov 9 2007, In : Neuroscience. 149, 3, p. 508-517 10 p.

Research output: Contribution to journalArticle

70 Scopus citations