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Show-Ling Shyng

Professor

  • 5085 Citations
  • 35 h-Index
1989 …2020
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  • 12 Similar Profiles
KATP Channels Medicine & Life Sciences
Sulfonylurea Receptors Medicine & Life Sciences
Congenital Hyperinsulinism Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
Mutation Medicine & Life Sciences
Insulin Medicine & Life Sciences
Diazoxide Medicine & Life Sciences
Potassium Channels Medicine & Life Sciences

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Projects 2000 2020

Structural Basis of Katp Channel Gating

Shyng, S.

National Institutes of Health

1/1/04 → 11/30/19

Project: Research project

KATP Channels
Congenital Hyperinsulinism
Mutation
ATP-Binding Cassette Transporters
Sulfonylurea Receptors

ATP-SENSITIVE POTASSIUM CHANNELS AND INSULIN SECRETION

Shyng, S.

National Institutes of Health

4/1/00 → 7/31/20

Project: Research project

KATP Channels
Insulin
Phosphatidylinositols
Congenital Hyperinsulinism
Mutation

Research Output 1989 2019

  • 5085 Citations
  • 35 h-Index
  • 78 Article
  • 3 Chapter

Functional characterization of activating mutations in the sulfonylurea receptor 1 (ABCC8) causing neonatal diabetes mellitus in Asian Indian children

Balamurugan, K., Kavitha, B., Yang, Z., Mohan, V., Radha, V. & Shyng, S-L., Jan 1 2019, In : Pediatric Diabetes.

Research output: Contribution to journal › Article

Sulfonylurea Receptors
Diabetes Mellitus
Adenosine Triphosphate
Mutation
Adenosine Diphosphate
2 Citations (Scopus)

Methods for characterizing disease-associated ATP-sensitive potassium channel mutations

Kandasamy, B. & Shyng, S-L., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1684. p. 85-104 20 p. (Methods in Molecular Biology; vol. 1684).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

KATP Channels
Sulfonylurea Receptors
Mutation
Congenital Hyperinsulinism
Insulin

Probing Subunits Interactions in KATP Channels Using Photo-Crosslinking via Genetically Encoded p-Azido-l-phenylalanine

Devaraneni, P., Rex, E. A. & Shyng, S-L., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1684. p. 51-61 11 p. (Methods in Molecular Biology; vol. 1684).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

KATP Channels
Phenylalanine
Ligands
Potassium Channels
Sulfonylurea Receptors
21 Citations (Scopus)

Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM

Martin, G. M., Kandasamy, B., Dimaio, F., Yoshioka, C. & Shyng, S-L., Oct 16 2017, In : eLife. 6, e31054.

Research output: Contribution to journal › Article

KATP Channels
Glyburide
Binding Sites
Pharmaceutical Preparations
Adenosine Triphosphate
52 Citations (Scopus)

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Martin, G. M., Yoshioka, C., Rex, E. A., Fay, J. F., Xie, Q., Whorton, M., Chen, J. Z. & Shyng, S-L., Jan 16 2017, In : eLife. 6, e24149.

Research output: Contribution to journal › Article

KATP Channels
Glyburide
Adenosine Triphosphate
Hypoglycemic Agents
Conformations