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  • 10 Similar Profiles
Adenosine Triphosphate Medicine & Life Sciences
Mutation Medicine & Life Sciences
KATP Channels Medicine & Life Sciences
Sulfonylurea Receptors Medicine & Life Sciences
Congenital Hyperinsulinism Medicine & Life Sciences
Insulin Medicine & Life Sciences
Defects Chemical Compounds
Proteins Medicine & Life Sciences

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Projects 2000 2020

Structural Basis of Katp Channel Gating

Shyng, S.

National Institutes of Health

1/1/0411/30/19

Project: Research projectResearch Project

KATP Channels
Mutation
Congenital Hyperinsulinism
Insulin
Pharmacology

ATP-SENSITIVE POTASSIUM CHANNELS AND INSULIN SECRETION

Shyng, S.

National Institutes of Health

4/1/007/31/20

Project: Research projectResearch Project

KATP Channels
Insulin
Mutation
Adenosine Triphosphate
Phosphatidylinositols

Research Output 1989 2018

  • 4709 Citations
  • 33 h-Index
  • 79 Article
  • 3 Chapter

Methods for characterizing disease-associated ATP-sensitive potassium channel mutations

Kandasamy, B. & Shyng, S. L. 2018 Methods in Molecular Biology. Humana Press Inc., Vol. 1684, p. 85-104 20 p. (Methods in Molecular Biology; vol. 1684)

Research output: ResearchChapter

KATP Channels
Mutation
Sulfonylurea Receptors
Adenosine Triphosphate
Insulin

Probing Subunits Interactions in KATP Channels Using Photo-Crosslinking via Genetically Encoded p-Azido-l-phenylalanine

Devaraneni, P., Rex, E. A. & Shyng, S. L. 2018 Methods in Molecular Biology. Humana Press Inc., Vol. 1684, p. 51-61 11 p. (Methods in Molecular Biology; vol. 1684)

Research output: ResearchChapter

Phenylalanine
Adenosine Triphosphate
Ligands
Proteins
Potassium Channels

Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM

Martin, G. M., Kandasamy, B., Dimaio, F., Yoshioka, C. & Shyng, S. L. Oct 16 2017 In : eLife. 6, e31054

Research output: Research - peer-reviewArticle

Glyburide
Adenosine Triphosphate
Binding Sites
Pharmaceutical Preparations
Lipid Bilayers
14 Citations

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Martin, G. M., Yoshioka, C., Rex, E. A., Fay, J. F., Xie, Q., Whorton, M. R., Chen, J. Z. & Shyng, S. L. Jan 16 2017 In : eLife. 6, e24149

Research output: Research - peer-reviewArticle

KATP Channels
Adenosine Triphosphate
Glyburide
Hypoglycemic Agents
Conformations

NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic Β-cells

Wu, Y., Fortin, D. A., Cochrane, V. A., Chen, P. C. & Shyng, S. L. 2017 In : Journal of Biological Chemistry. 292, 37, p. 15512-15524 13 p.

Research output: Research - peer-reviewArticle

Potassium Channels
Leptin
N-Methyl-D-Aspartate Receptors
AMP-Activated Protein Kinases
Adenosine Triphosphate