Show-Ling Shyng

Professor

  • 4890 Citations
  • 35 h-Index
1989 …2020
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  • 10 Similar Profiles
Sulfonylurea Receptors Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
KATP Channels Medicine & Life Sciences
Congenital Hyperinsulinism Medicine & Life Sciences
Mutation Medicine & Life Sciences
Insulin Medicine & Life Sciences
Diazoxide Medicine & Life Sciences
Potassium Channels Medicine & Life Sciences

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Projects 2000 2020

Structural Basis of Katp Channel Gating

Shyng, S.

National Institutes of Health

1/1/0411/30/19

Project: Research projectResearch Project

KATP Channels
Congenital Hyperinsulinism
Mutation
ATP-Binding Cassette Transporters
Sulfonylurea Receptors

ATP-SENSITIVE POTASSIUM CHANNELS AND INSULIN SECRETION

Shyng, S.

National Institutes of Health

4/1/007/31/20

Project: Research projectResearch Project

KATP Channels
Insulin
Phosphatidylinositols
Congenital Hyperinsulinism
Mutation

Research Output 1989 2018

  • 4890 Citations
  • 35 h-Index
  • 78 Article
  • 3 Chapter
1 Citations

Methods for characterizing disease-associated ATP-sensitive potassium channel mutations

Kandasamy, B. & Shyng, S. L. 2018 Methods in Molecular Biology. Humana Press Inc., Vol. 1684, p. 85-104 20 p. (Methods in Molecular Biology; vol. 1684)

Research output: Chapter in Book/Report/Conference proceedingChapter

KATP Channels
Sulfonylurea Receptors
Mutation
Congenital Hyperinsulinism
Adenosine Triphosphate

Probing Subunits Interactions in KATP Channels Using Photo-Crosslinking via Genetically Encoded p-Azido-l-phenylalanine

Devaraneni, P., Rex, E. A. & Shyng, S. L. 2018 Methods in Molecular Biology. Humana Press Inc., Vol. 1684, p. 51-61 11 p. (Methods in Molecular Biology; vol. 1684)

Research output: Chapter in Book/Report/Conference proceedingChapter

Phenylalanine
Adenosine Triphosphate
Ligands
Potassium Channels
Sulfonylurea Receptors
8 Citations

Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM

Martin, G. M., Kandasamy, B., Dimaio, F., Yoshioka, C. & Shyng, S. L. Oct 16 2017 In : eLife. 6, e31054

Research output: Contribution to journalArticle

Glyburide
Adenosine Triphosphate
Binding Sites
Pharmaceutical Preparations
Lipid bilayers
32 Citations

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Martin, G. M., Yoshioka, C., Rex, E. A., Fay, J. F., Xie, Q., Whorton, M. R., Chen, J. Z. & Shyng, S. L. Jan 16 2017 In : eLife. 6, e24149

Research output: Contribution to journalArticle

KATP Channels
Glyburide
Adenosine Triphosphate
Hypoglycemic Agents
Conformations

NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic Β-cells

Wu, Y., Fortin, D. A., Cochrane, V. A., Chen, P. C. & Shyng, S. L. 2017 In : Journal of Biological Chemistry. 292, 37, p. 15512-15524 13 p.

Research output: Contribution to journalArticle

Potassium Channels
Leptin
N-Methyl-D-Aspartate Receptors
AMP-Activated Protein Kinases
Adenosine Triphosphate