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Show-Ling Shyng

Professor

  • 5194 Citations
  • 36 h-Index
1989 …2020
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  • 10 Similar Profiles
KATP Channels Medicine & Life Sciences
Sulfonylurea Receptors Medicine & Life Sciences
Congenital Hyperinsulinism Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
Mutation Medicine & Life Sciences
Insulin Medicine & Life Sciences
Diazoxide Medicine & Life Sciences
Potassium Channels Medicine & Life Sciences

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Projects 2000 2020

Structural Basis of Katp Channel Gating

Shyng, S.

National Institutes of Health

1/1/04 → 11/30/19

Project: Research project

KATP Channels
Congenital Hyperinsulinism
Mutation
ATP-Binding Cassette Transporters
Sulfonylurea Receptors

ATP-SENSITIVE POTASSIUM CHANNELS AND INSULIN SECRETION

Shyng, S.

National Institutes of Health

4/1/00 → 7/31/20

Project: Research project

KATP Channels
Insulin
Phosphatidylinositols
Congenital Hyperinsulinism
Mutation

Research Output 1989 2019

  • 5194 Citations
  • 36 h-Index
  • 80 Article
  • 3 Chapter
  • 1 Review article
1 Citation (Scopus)

Functional characterization of activating mutations in the sulfonylurea receptor 1 (ABCC8) causing neonatal diabetes mellitus in Asian Indian children

Balamurugan, K., Kavitha, B., Yang, Z., Mohan, V., Radha, V. & Shyng, S-L., Jan 1 2019, In : Pediatric Diabetes.

Research output: Contribution to journal › Article

Sulfonylurea Receptors
Diabetes Mellitus
Adenosine Triphosphate
Mutation
Adenosine Diphosphate

Leptin-induced Trafficking of KATP Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion

Cochrane, V. & Shyng, S-L., May 30 2019, In : International journal of molecular sciences. 20, 11

Research output: Contribution to journal › Review article

Open Access
KATP Channels
insulin
secretions
Insulin
Leptin

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

Martin, G. M., Sung, M. W., Yang, Z., Innes, L. M., Kandasamy, B., David, L., Yoshioka, C. & Shyng, S-L., Jul 1 2019, In : eLife. 8, e46417.

Research output: Contribution to journal › Article

Open Access
Sulfonylurea Receptors
KATP Channels
repaglinide
Congenital Hyperinsulinism
ATP-Binding Cassette Transporters

Novel dominant KATP channel mutations in infants with congenital hyperinsulinism: Validation by in vitro expression studies and in vivo carrier phenotyping

Boodhansingh, K. E., Kandasamy, B., Mitteer, L., Givler, S., De Leon, D. D., Shyng, S-L., Ganguly, A. & Stanley, C. A., Jan 1 2019, (Accepted/In press) In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journal › Article

Open Access
Congenital Hyperinsulinism
KATP Channels
Mutation
Hypoglycemia
Diazoxide
2 Citations (Scopus)

Methods for characterizing disease-associated ATP-sensitive potassium channel mutations

Kandasamy, B. & Shyng, S-L., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1684. p. 85-104 20 p. (Methods in Molecular Biology; vol. 1684).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

KATP Channels
Sulfonylurea Receptors
Mutation
Congenital Hyperinsulinism
Insulin