Show-Ling Shyng

Professor

  • 4890 Citations
  • 35 h-Index
1989 …2020
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Research Output 1989 2018

  • 4890 Citations
  • 35 h-Index
  • 78 Article
  • 3 Chapter
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Article
2017
8 Citations

Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM

Martin, G. M., Kandasamy, B., Dimaio, F., Yoshioka, C. & Shyng, S. L. Oct 16 2017 In : eLife. 6, e31054

Research output: Contribution to journalArticle

Glyburide
Adenosine Triphosphate
Binding Sites
Pharmaceutical Preparations
Lipid bilayers
32 Citations

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Martin, G. M., Yoshioka, C., Rex, E. A., Fay, J. F., Xie, Q., Whorton, M. R., Chen, J. Z. & Shyng, S. L. Jan 16 2017 In : eLife. 6, e24149

Research output: Contribution to journalArticle

KATP Channels
Glyburide
Adenosine Triphosphate
Hypoglycemic Agents
Conformations

NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic Β-cells

Wu, Y., Fortin, D. A., Cochrane, V. A., Chen, P. C. & Shyng, S. L. 2017 In : Journal of Biological Chemistry. 292, 37, p. 15512-15524 13 p.

Research output: Contribution to journalArticle

Potassium Channels
Leptin
N-Methyl-D-Aspartate Receptors
AMP-Activated Protein Kinases
Adenosine Triphosphate

Targeting the gut microbiota-FXR signaling axis for glycemic control: Does a dietary supplement work Magic?

Shyng, S. L. Mar 1 2017 In : Diabetes. 66, 3, p. 571-573 3 p.

Research output: Contribution to journalArticle

Magic
Dietary Supplements
Gastrointestinal Microbiome
2016
5 Citations

Pharmacological correction of trafficking defects in ATP-sensitive potassium channels caused by sulfonylurea receptor 1 mutations

Martin, G. M., Rex, E. A., Devaraneni, P., Denton, J. S., Boodhansingh, K. E., DeLeon, D. D., Stanley, C. A. & Shyng, S. L. Oct 14 2016 In : Journal of Biological Chemistry. 291, 42, p. 21971-21983 13 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
KATP Channels
Adenosine Triphosphate
Pharmacology
Defects
2015
7 Citations

Concerted trafficking regulation of Kv2.1 and KATP channels by leptin in pancreatic β-cells

Wu, Y., Shyng, S. L. & Chen, P. C. Dec 11 2015 In : Journal of Biological Chemistry. 290, 50, p. 29676-29690 15 p.

Research output: Contribution to journalArticle

Insulin-Secreting Cells
Leptin
Adenosine Triphosphate
Depolymerization
AMP-Activated Protein Kinases
7 Citations

Monoallelic ABCC8 mutations are a common cause of diazoxide-unresponsive diffuse form of congenital hyperinsulinism

Saint-Martin, C., Zhou, Q., Martin, G. M., Vaury, C., Leroy, G., Arnoux, J. B., de Lonlay, P., Shyng, S. L. & Bellanné-Chantelot, C. May 1 2015 In : Clinical Genetics. 87, 5, p. 448-454 7 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
Diazoxide
Mutation
Adenosine Triphosphate
Missense Mutation
9 Citations

Structurally distinct ligands rescue biogenesis defects of the KATP channel complex via a converging mechanism

Devaraneni, P. K., Olson, E. M., Zhou, Q. & Shyng, S. L. Mar 20 2015 In : Journal of Biological Chemistry. 290, 12, p. 7980-7991 12 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
KATP Channels
Glyburide
Ligands
Carbamazepine
2014
8 Citations

Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP

Zhou, Q., Chen, P. C., Devaraneni, P. K., Martin, G. M., Olson, E. M. & Shyng, S. L. 2014 In : Channels. 8, 4, p. 376-382 7 p.

Research output: Contribution to journalArticle

KATP Channels
Carbamazepine
Adenosine Diphosphate
Adenosine Triphosphate
Bearings (structural)
1 Citations

Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels

Xie, L., Liang, T., Kang, Y., Lin, X., Sobbi, R., Xie, H., Chao, C., Backx, P., Feng, Z. P., Shyng, S. L. & Gaisano, H. Y. Oct 1 2014 In : Journal of Molecular and Cellular Cardiology. 75, p. 100-110 11 p.

Research output: Contribution to journalArticle

Syntaxin 1
Sulfonylurea Receptors
Phosphatidylinositol 4,5-Diphosphate
Potassium
Adenosine Triphosphate
2013
3 Citations

A Kir6.2 Pore Mutation Causes Inactivation of ATP-Sensitive Potassium Channels by Disrupting PIP2-Dependent Gating

Bushman, J. D., Zhou, Q. & Shyng, S. L. May 20 2013 In : PLoS One. 8, 5, e63733

Research output: Contribution to journalArticle

KATP Channels
potassium channels
inactivation
Adenosine Triphosphate
mutation
26 Citations

Carbamazepine as a novel small molecule corrector of trafficking-impaired atp-sensitive potassium channels identified in congenital hyperinsulinism

Chen, P. C., Olson, E. M., Zhou, Q., Kryukova, Y., Sampson, H. M., Thomas, D. Y. & Shyng, S. L. Jul 19 2013 In : Journal of Biological Chemistry. 288, 29, p. 20942-20954 13 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
Potassium Channels
Carbamazepine
Adenosine Triphosphate
Molecules
6 Citations

Co-inheritance of two ABCC8 mutations causing an unresponsive congenital hyperinsulinism: Clinical and functional characterization of two novel ABCC8 mutations

Faletra, F., Snider, K., Shyng, S. L., Bruno, I., Athanasakis, E., Gasparini, P., Dionisi-Vici, C., Ventura, A., Zhou, Q., Stanley, C. A. & Burlina, A. Mar 1 2013 In : Gene. 516, 1, p. 122-125 4 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
Mutation
Diazoxide
Null Lymphocytes
Insulin-Secreting Cells
22 Citations

Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: An in vitro study using cell lines

Sampson, H. M., Lam, H., Chen, P. C., Zhang, D., Mottillo, C., Mirza, M., Qasim, K., Shrier, A., Shyng, S. L., Hanrahan, J. W. & Thomas, D. Y. Jan 14 2013 (Accepted/In press) In : Orphanet Journal of Rare Diseases. p. 11 1 p.

Research output: Contribution to journalArticle

Protein Transport
Mutant Proteins
Cell Line
Alleles
Sulfonylurea Receptors
3 Citations

Engineered Kir6.2 mutations that correct the trafficking defect of K ATP channels caused by specific SUR1 mutations

Zhou, Q., Pratt, E. B. & Shyng, S. L. 2013 In : Channels. 7, 4, p. 313-317 5 p.

Research output: Contribution to journalArticle

Adenosine Triphosphate
Defects
Mutation
Molecular interactions
Cell membranes
85 Citations

Genotype and phenotype correlations in 417 children with congenital hyperinsulinism

Snider, K. E., Becker, S., Boyajian, L., Shyng, S. L., MacMullen, C., Hughes, N., Ganapathy, K., Bhatti, T., Stanley, C. A. & Ganguly, A. Feb 2013 In : Journal of Clinical Endocrinology and Metabolism. 98, 2

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
Diazoxide
Genetic Association Studies
Mutation
Genes
27 Citations
AMP-Activated Protein Kinases
Insulin-Secreting Cells
Leptin
Protein Kinases
Adenosine Triphosphate
21 Citations

Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels

Martin, G. M., Chen, P. C., Devaraneni, P. & Shyng, S. L. 2013 In : Frontiers in Physiology. 4 DEC, Article 386

Research output: Contribution to journalArticle

KATP Channels
Congenital Hyperinsulinism
Adenosine Triphosphate
Pharmacology
Mutation
2012
13 Citations

Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels

Pratt, E. B., Zhou, Q., Gay, J. W. & Shyng, S. L. Aug 2012 In : Journal of General Physiology. 140, 2, p. 175-187 13 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
KATP Channels
Adenosine Triphosphate
Reducing Agents
Potassium
7 Citations

Relative expression of a dominant mutated ABCC8 allele determines the clinical manifestation of congenital hyperinsulinism

Shemer, R., Ziv, C. A., Laiba, E., Zhou, Q., Gay, J., Tunovsky-Babaey, S., Shyng, S. L., Glaser, B. & Zangen, D. H. Jan 2012 In : Diabetes. 61, 1, p. 258-263 6 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
Alleles
Sulfonylurea Receptors
Mothers
Phenotype
15 Citations

Role of Derlin-1 protein in proteostasis regulation of ATP-sensitive potassium channels

Wang, F., Olson, E. M. & Shyng, S. L. Mar 23 2012 In : Journal of Biological Chemistry. 287, 13, p. 10482-10493 12 p.

Research output: Contribution to journalArticle

KATP Channels
Sulfonylurea Receptors
Adenosine Triphosphate
Proteins
Proteasome Endopeptidase Complex
6 Citations

Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K ATP channels

Lynch, C. J., Zhou, Q., Shyng, S. L., Heal, D. J., Cheetham, S. C., Dickinson, K., Gregory, P., Firnges, M., Nordheim, U., Goshorn, S., Reiche, D., Turski, L. & Antel, J. Mar 2012 In : American Journal of Physiology - Endocrinology and Metabolism. 302, 5

Research output: Contribution to journalArticle

rimonabant
Cannabinoid Receptors
Diazoxide
Adenosine Triphosphate
Ligands
2011
10 Citations

A Role of the Sulfonylurea Receptor 1 in Endocytic Trafficking of ATP-Sensitive Potassium Channels

Bruederle, C. E., Gay, J. & Shyng, S. L. Sep 2011 In : Traffic. 12, 9, p. 1242-1256 15 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
KATP Channels
Endocytosis
Adenosine Triphosphate
Inwardly Rectifying Potassium Channel
3 Citations
Sulfonylurea Receptors
KATP Channels
Adenosine Triphosphate
Phosphatidylinositols
Potassium
12 Citations

ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-Cell KATP channels

Kang, Y., Zhang, Y., Liang, T., Leung, Y. M., Ng, B., Xie, H., Chang, N., Chan, J., Shyng, S. L., Tsushima, R. G. & Gaisano, H. Y. Feb 18 2011 In : Journal of Biological Chemistry. 286, 7, p. 5876-5883 8 p.

Research output: Contribution to journalArticle

Syntaxin 1
Sulfonylurea Receptors
KATP Channels
Insulin-Secreting Cells
Adenosine Triphosphate
36 Citations

Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the β-cell sulfonylurea receptor SUR1

MacMullen, C. M., Zhou, Q., Snider, K. E., Tewson, P. H., Becker, S. A., Aziz, A. R., Ganguly, A., Shyng, S. L. & Stanley, C. A. Jun 2011 In : Diabetes. 60, 6, p. 1797-1804 8 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
Sulfonylurea Receptors
Diazoxide
Mutation
Adenosine Triphosphate

Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the β-cell sulfonylurea receptor SUR1 (Diabetes (2011) 60, (1797-1804))

MacMullen, C. M., Zhou, Q., Snider, K. E., Tewson, P. H., Becker, S. A., Aziz, A. R., Ganguly, A., Shyng, S. L. & Stanley, C. A. Nov 2011 In : Diabetes. 60, 11, p. 3097 1 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
Sulfonylurea Receptors
Diazoxide
Mutation
18 Citations

N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2

Pratt, E. B., Tewson, P., Bruederle, C. E., Skach, W. R. & Shyng, S. L. Mar 2011 In : Journal of General Physiology. 137, 3, p. 299-314 16 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
Adenosine Triphosphate
ritrosulfan
Mutation
Potassium Channels
20 Citations

Syntaxin 1A regulates surface expression of β-cell ATP-sensitive potassium channels

Chen, P. C., Bruederle, C. E., Gaisano, H. Y. & Shyng, S. L. Mar 2011 In : American Journal of Physiology - Cell Physiology. 300, 3

Research output: Contribution to journalArticle

Syntaxin 1
KATP Channels
Adenosine Triphosphate
Inwardly Rectifying Potassium Channel
Insulin
2010
7 Citations

Characterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinism

Bushman, J. D., Gay, J. W., Tewson, P., Stanley, C. A. & Shyng, S. L. Feb 26 2010 In : Journal of Biological Chemistry. 285, 9, p. 6012-6023 12 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
Potassium Channels
Restoration
Adenosine Triphosphate
Glycine
14 Citations

Neonatal diabetes caused by mutations in sulfonylurea receptor 1: Interplay between expression and Mg-nucleotide gating defects of ATP-sensitive potassium channels

Zhou, Q., Garin, I., Castaño, L., Argente, J., Muñoz-Calvo, M. T., De Nanclares, G. P. & Shyng, S. L. Dec 2010 In : Journal of Clinical Endocrinology and Metabolism. 95, 12

Research output: Contribution to journalArticle

Sulfonylurea Receptors
KATP Channels
Medical problems
Nucleotides
Defects
27 Citations

Role of Hsp90 in biogenesis of the β-cell ATP-sensitive potassium channel complex

Yan, F. F., Pratt, E. B., Chen, P. C., Wang, F., Skach, W. R., David, L. L. & Shyng, S. L. Jun 15 2010 In : Molecular Biology of the Cell. 21, 12, p. 1945-1954 10 p.

Research output: Contribution to journalArticle

KATP Channels
Sulfonylurea Receptors
Adenosine Triphosphate
Proteins
HSC70 Heat-Shock Proteins
2009
52 Citations

Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion

Fu, Y., Tian, W., Pratt, E. B., Dirling, L. B., Shyng, S. L., Meshul, C. K. & Cohen, D. M. May 25 2009 In : PLoS One. 4, 5, e5679

Research output: Contribution to journalArticle

insulin secretion
islets of Langerhans
Insulin-Secreting Cells
Rats
insulin
22 Citations

Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure

Pratt, E. B., Yan, F. F., Gay, J. W., Stanley, C. A. & Shyng, S. L. Mar 20 2009 In : Journal of Biological Chemistry. 284, 12, p. 7951-7959 9 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
Adenosine Triphosphate
Insulin
Defects
Mutation
2008
121 Citations

Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations

Pinney, S. E., MacMullen, C., Becker, S., Lin, Y. W., Hanna, C., Thornton, P., Ganguly, A., Shyng, S. L. & Stanley, C. A. Aug 1 2008 In : Journal of Clinical Investigation. 118, 8, p. 2877-2886 10 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
KATP Channels
Adenosine Triphosphate
Mutation
Diazoxide
35 Citations

Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism

Lin, Y. W., Bushman, J. D., Yan, F. F., Haidar, S., MacMullen, C., Ganguly, A., Stanley, C. A. & Shyng, S. L. Apr 4 2008 In : Journal of Biological Chemistry. 283, 14, p. 9146-9156 11 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
KATP Channels
Insulin
Defects
Mutation

Erratum: Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence (Diabetes (2008) 57 (1935-1940))

Abdulhadi-Atwan, M., Bushmann, J., Tornovsky-Babaey, S., Perry, A., Abu-Libdeh, A., Glaser, B., Shyng, S. L. & Zangen, D. H. Sep 2008 In : Diabetes. 57, 9, p. 2552 1 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
Hyperinsulinism
Mutation
27 Citations

Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence

Abdulhadi-Atwan, M., Bushman, J. D., Tornovsky-Babaey, S., Perry, A., Abu-Libdeh, A., Glaser, B., Shyng, S. L. & Zangen, D. H. Jul 2008 In : Diabetes. 57, 7, p. 1935-1940 6 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
Hyperinsulinism
Mutation
Congenital Hyperinsulinism
Glucose
2007
56 Citations

Congenital hyperinsulinism-associated ABCC8 mutations that cause defective trafficking of ATP-sensitive K+ channels: Identification and rescue

Yan, F. F., Lin, Y. W., MacMullen, C., Ganguly, A., Stanley, C. A. & Shyng, S. L. Sep 2007 In : Diabetes. 56, 9, p. 2339-2348 10 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
Sulfonylurea Receptors
Adenosine Triphosphate
Mutation
Diazoxide
2006
55 Citations

A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of β-cell ATP-sensitive potassium channels

Lin, Y. W., MacMullen, C., Ganguly, A., Stanley, C. A. & Shyng, S. L. Feb 3 2006 In : Journal of Biological Chemistry. 281, 5, p. 3006-3012 7 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
KATP Channels
Adenosine Triphosphate
Mutation
Phospholipids
26 Citations

Kir6.2 mutations associated with neonatal diabetes reduce expression of ATP-sensitive K+ channels: Implications in disease mechanism and sulfonylurea therapy

Lin, C. W., Lin, Y. W., Yan, F. F., Casey, J., Kochhar, M., Pratt, E. B. & Shyng, S. L. 2006 In : Diabetes. 55, 6, p. 1738-1746 9 p.

Research output: Contribution to journalArticle

Adenosine Triphosphate
Mutation
Therapeutics
Polyamines
Missense Mutation
32 Citations

Sulfonylureas correct trafficking defects of disease-causing ATP-sensitive potassium channels by binding to the channel complex

Yan, F. F., Casey, J. & Shyng, S. L. Nov 3 2006 In : Journal of Biological Chemistry. 281, 44, p. 33403-33413 11 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
KATP Channels
Defects
Mutation
Adenosine Triphosphate
2005
35 Citations

Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity

Lin, C. W., Yan, F., Shimamura, S., Barg, S. & Shyng, S. L. Oct 2005 In : Diabetes. 54, 10, p. 2852-2858 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Adenosine Triphosphate
Insulin
Membranes
Glucose
47 Citations

Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of β-cell ATP-sensitive potassium channels

Yan, F. F., Lin, C. W., Cartier, E. A. & Shyng, S. L. Nov 2005 In : American Journal of Physiology - Cell Physiology. 289, 5 58-5

Research output: Contribution to journalArticle

KATP Channels
Proteasome Endopeptidase Complex
Ubiquitin
Adenosine Triphosphate
Degradation
2004

ATP-sensitive potassium channels and insulin secretion diseases

Nichols, C. G., Shyng, S. L., Marshall, B. & Koster, J. C. 2004 In : Advances in Molecular and Cell Biology. 32, p. 1-14 14 p.

Research output: Contribution to journalArticle

KATP Channels
Insulin
54 Citations

Familial leucine-sensitive hypoglycemia of infancy due to a dominant mutation of the β-cell sulfonylurea receptor

Magge, S. N., Shyng, S. L., MacMullen, C., Steinkrauss, L., Ganguly, A., Katz, L. E. L. & Stanley, C. A. Sep 2004 In : Journal of Clinical Endocrinology and Metabolism. 89, 9, p. 4450-4456 7 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
Hypoglycemia
Leucine
Mutation
Hyperinsulinism
77 Citations

Sulfonylureas Correct Trafficking Defects of ATP-sensitive Potassium Channels Caused by Mutations in the Sulfonylurea Receptor

Yan, F., Lin, C. W., Weisiger, E., Cartier, E. A., Taschenberger, G. & Shyng, S. L. Mar 19 2004 In : Journal of Biological Chemistry. 279, 12, p. 11096-11105 10 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
KATP Channels
Adenosine Triphosphate
Defects
Mutation
2003
25 Citations
Sulfonylurea Receptors
KATP Channels
Adenosine Triphosphate
Modulation
Amino Acids
41 Citations

Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 Subunits

Lin, Y. W., Jia, T., Weinsoft, A. M. & Shyng, S. L. Aug 1 2003 In : Journal of General Physiology. 122, 2, p. 225-237 13 p.

Research output: Contribution to journalArticle

KATP Channels
arginine glutamate
Ions
Adenosine Triphosphate
Phosphatidylinositols
2002
93 Citations

Identification of a familial hyperinsulinism-causing mutation in the sulfonylurea receptor 1 that prevents normal trafficking and function of KATP channels

Taschenberger, G., Mougey, A., Shen, S., Lester, L. B., Lafranchi, S. & Shyng, S. L. May 10 2002 In : Journal of Biological Chemistry. 277, 19, p. 17139-17146 8 p.

Research output: Contribution to journalArticle

Congenital Hyperinsulinism
Sulfonylurea Receptors
KATP Channels
Mutation
Adenosine Triphosphate