• 4126 Citations
  • 35 h-Index
1974 …2021

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Article
2019

Sensing What's Out There – Kinetoplastid Parasites

Landfear, S. & Zilberstein, D., Jan 1 2019, (Accepted/In press) In : Trends in Parasitology.

Research output: Contribution to journalArticle

2018

Glucose Transporters and Virulence in Leishmania mexicana

Feng, X., Tran, K. D., Sanchez, M., Al Mezewghi, H. & Landfear, S., Aug 1 2018, In : mSphere. 3, 4

Research output: Contribution to journalArticle

2 Scopus citations

Leishmania mexicana can utilize amino acids as major carbon sources in macrophages but not in animal models

Saunders, E. C., Naderer, T., Chambers, J., Landfear, S. & Mcconville, M. J., Jan 1 2018, (Accepted/In press) In : Molecular Microbiology.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening

Ortiz, D., Guiguemde, W. A., Hammill, J. T., Carrillo, A. K., Chen, Y., Connelly, M., Stalheim, K., Elya, C., Johnson, A., Min, J., Shelat, A., Smithson, D. C., Yang, L., Zhu, F., Guy, R. K. & Landfear, S., Dec 1 2017, In : PLoS Neglected Tropical Diseases. 11, 12, p. e0006157

Research output: Contribution to journalArticle

5 Scopus citations
2016

KHARON is an essential cytoskeletal protein involved in the trafficking of flagellar membrane proteins and cell division in african trypanosomes

Sanchez, M. A., Tran, K. D., Valli, J., Hobbs, S., Johnson, E., Gluenz, E. & Landfear, S. M., Sep 16 2016, In : Journal of Biological Chemistry. 291, 38, p. 19760-19773 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Van Voorhis, W. C., Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., Alano, P., Alday, A., Alemán Resto, Y., Alsibaee, A., Alzualde, A., Andrews, K. T., Avery, S. V., Avery, V. M., Ayong, L., Baker, M., Baker, S., Ben Mamoun, C., Bhatia, S., Bickle, Q., Bounaadja, L. & 167 others, Bowling, T., Bosch, J., Boucher, L. E., Boyom, F. F., Brea, J., Brennan, M., Burton, A., Caffrey, C. R., Camarda, G., Carrasquilla, M., Carter, D., Belen Cassera, M., Chih-Chien Cheng, K., Chindaudomsate, W., Chubb, A., Colon, B. L., Colón-López, D. D., Corbett, Y., Crowther, G. J., Cowan, N., D’Alessandro, S., Le Dang, N., Delves, M., DeRisi, J. L., Du, A. Y., Duffy, S., Abd El-Salam El-Sayed, S., Ferdig, M. T., Fernández Robledo, J. A., Fidock, D. A., Florent, I., Fokou, P. V. T., Galstian, A., Gamo, F. J., Gokool, S., Gold, B., Golub, T., Goldgof, G. M., Guha, R., Guiguemde, W. A., Gural, N., Guy, R. K., Hansen, M. A. E., Hanson, K. K., Hemphill, A., Hooft van Huijsduijnen, R., Horii, T., Horrocks, P., Hughes, T. B., Huston, C., Igarashi, I., Ingram-Sieber, K., Itoe, M. A., Jadhav, A., Naranuntarat Jensen, A., Jensen, L. T., Jiang, R. H. Y., Kaiser, A., Keiser, J., Ketas, T., Kicka, S., Kim, S., Kirk, K., Kumar, V. P., Kyle, D. E., Lafuente, M. J., Landfear, S., Lee, N., Lee, S., Lehane, A. M., Li, F., Little, D., Liu, L., Llinás, M., Loza, M. I., Lubar, A., Lucantoni, L., Lucet, I., Maes, L., Mancama, D., Mansour, N. R., March, S., McGowan, S., Medina Vera, I., Meister, S., Mercer, L., Mestres, J., Mfopa, A. N., Misra, R. N., Moon, S., Moore, J. P., Morais Rodrigues da Costa, F., Müller, J., Muriana, A., Nakazawa Hewitt, S., Nare, B., Nathan, C., Narraidoo, N., Nawaratna, S., Ojo, K. K., Ortiz, D., Panic, G., Papadatos, G., Parapini, S., Patra, K., Pham, N., Prats, S., Plouffe, D. M., Poulsen, S. A., Pradhan, A., Quevedo, C., Quinn, R. J., Rice, C. A., Rizk, M. A., Ruecker, A., St. Onge, R., Salgado Ferreira, R., Samra, J., Robinett, N. G., Schlecht, U., Schmitt, M., Silva Villela, F., Silvestrini, F., Sinden, R., Smith, D. A., Soldati, T., Spitzmüller, A., Stamm, S. M., Sullivan, D. J., Sullivan, W., Suresh, S., Suzuki, B. M., Suzuki, Y., Swamidass, S. J., Taramelli, D., Tchokouaha, L. R. Y., Theron, A., Thomas, D., Tonissen, K. F., Townson, S., Tripathi, A. K., Trofimov, V., Udenze, K. O., Ullah, I., Vallieres, C., Vigil, E., Vinetz, J. M., Voong Vinh, P., Vu, H., Watanabe, N. A., Weatherby, K., White, P. M., Wilks, A. F., Winzeler, E. A., Wojcik, E., Wree, M., Wu, W., Yokoyama, N., Zollo, P. H. A., Abla, N., Blasco, B., Burrows, J., Laleu, B., Leroy, D., Spangenberg, T., Wells, T. & Willis, P. A., Jul 2016, In : PLoS pathogens. 12, 7, e1005763.

Research output: Contribution to journalArticle

110 Scopus citations

Targeting the cytochrome bc1 complex of Leishmania parasites for discovery of novel drugs

Ortiz, D., Forquer, I., Boitz, J., Soysa, R., Elya, C., Fulwiler, A., Nilsen, A., Polley, T., Riscoe, M., Ullman, B. & Landfear, S., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4972-4982 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Identification of selective inhibitors of the Plasmodium falciparum hexose transporter PfHT by screening focused libraries of anti-malarial compounds

Ortiz, D., Guiguemde, W. A., Johnson, A., Elya, C., Anderson, J., Clark, J., Connelly, M., Yang, L., Min, J., Sato, Y., Guy, R. K. & Landfear, S. M., Apr 20 2015, In : PloS one. 10, 4, e0123598.

Research output: Contribution to journalArticle

18 Scopus citations

Kharon1 null mutants of leishmania Mexicana are avirulent in mice and exhibit a cytokinesis defect within macrophages

Tran, K. D., Vieira, D. P., Sanchez, M. A., Valli, J., Gluenz, E. & Landfear, S. M., Aug 12 2015, In : PloS one. 10, 8, e0134432.

Research output: Contribution to journalArticle

7 Scopus citations

Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: A potential glucose sensor

Rodriguez-Contreras, D., Aslan, H., Feng, X., Tran, K., Yates, P. A., Kamhawi, S. & Landfear, S. M., Jan 1 2015, In : FASEB Journal. 29, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014

Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family

Valdés, R., Elferich, J., Shinde, U. & Landfear, S. M., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8799-8809 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes

Tran, K. D., Rodriguez-Contreras, D., Vieira, D. P., Yates, P. A., David, L., Beatty, W., Elferich, J. & Landfear, S. M., Aug 2 2013, In : Journal of Biological Chemistry. 288, 31, p. 22721-22733 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana

Feng, X., Rodriguez-Contreras, D., Polley, T., Lye, L. F., Scott, D., Burchmore, R. J. S., Beverley, S. M. & Landfear, S. M., Jan 1 2013, In : Molecular Microbiology. 87, 2, p. 412-429 18 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Both sequence and context are important for flagellar targeting of a glucose transporter

Tran, K. D., Rodriguez-Contreras, D., Shinde, U. & Landfear, S. M., Jul 15 2012, In : Journal of Cell Science. 125, 14, p. 3293-3298 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1)

Valdés, R., Shinde, U. & Landfear, S. M., Dec 28 2012, In : Journal of Biological Chemistry. 287, 53, p. 44036-44045 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs

Blume, M., Hliscs, M., Rodriguez-Contreras, D., Sanchez, M., Landfear, S., Lucius, R., Matuschewski, K. & Gupta, N., Apr 1 2011, In : FASEB Journal. 25, 4, p. 1218-1229 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Lysosomal degradation of Leishmania hexose and inositol transporters is regulated in a stage-, nutrient- and ubiquitin-dependent manner

Vince, J. E., Tull, D., Landfear, S. & McConville, M. J., Jun 1 2011, In : International Journal for Parasitology. 41, 7, p. 791-800 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nutrient transport and pathogenesis in selected parasitic protozoa

Landfear, S. M., Apr 1 2011, In : Eukaryotic Cell. 10, 4, p. 483-493 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes

Feng, X., Feistel, T., Buffalo, C., McCormack, A., Kruvand, E., Rodriguez-Contreras, D., Akopyants, N. S., Umasankar, P. K., David, L., Jardim, A., Beverley, S. M. & Landfear, S. M., Jan 1 2011, In : Molecular and Biochemical Parasitology. 175, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2010

Adaptive responses to purine starvation in Leishmania donovani

Carter, N. S., Yates, P. A., Gessford, S. K., Galagan, S. R., Landfear, S. M. & Ullman, B., Oct 1 2010, In : Molecular Microbiology. 78, 1, p. 92-107 16 p.

Research output: Contribution to journalArticle

32 Scopus citations

Glucose transporters in parasitic protozoa.

Landfear, S. M., 2010, In : Methods in molecular biology (Clifton, N.J.). 637, p. 245-262 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Purine restriction induces pronounced translational upregulation of the NT1 adenosine/pyrimidine nucleoside transporter in Leishmania major

Ortiz, D., Valdés, R., Sanchez, M. A., Hayenga, J., Elya, C., Detke, S. & Landfear, S. M., Oct 1 2010, In : Molecular Microbiology. 78, 1, p. 108-118 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2009

Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana

Feng, X., Rodriguez-Contreras, D., Buffalo, C., Bouwer, H. G. A., Kruvand, E., Beverley, S. M. & Landfear, S. M., Jan 1 2009, In : Molecular Microbiology. 71, 2, p. 369-381 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

An ab initio structural model of a nucleoside permease predicts functionally important residues

Valdés, R., Arastu-Kapur, S., Landfear, S. M. & Shinde, U., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 19067-19076 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

An acid-activated nucleobase transporter from Leishmania major

Ortiz, D., Sanchez, M. A., Koch, H. P., Larson, H. P. & Landfear, S. M., Jun 12 2009, In : Journal of Biological Chemistry. 284, 24, p. 16164-16169 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Arsenic transport by zebrafish aquaglyceroporins

Hamdi, M., Sanchez, M. A., Beene, L. C., Liu, Q., Landfear, S. M., Rosen, B. P. & Liu, Z., Nov 25 2009, In : BMC Molecular Biology. 10, 104.

Research output: Contribution to journalArticle

51 Scopus citations

Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis

Blume, M., Rodriguez-Contreras, D., Landfear, S., Fleige, T., Soldati-Favre, D., Lucius, R. & Gupta, N., Aug 4 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 31, p. 12998-13003 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Two novel nucleobase/pentamidine transporters from Trypanosoma brucei

Ortiz, D., Sanchez, M. A., Quecke, P. & Landfear, S. M., Feb 1 2009, In : Molecular and Biochemical Parasitology. 163, 2, p. 67-76 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2008

An expression system to screen for inhibitors of parasite glucose transporters

Feistel, T., Hodson, C. A., Peyton, D. H. & Landfear, S. M., Nov 1 2008, In : Molecular and Biochemical Parasitology. 162, 1, p. 71-76 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2007

Down-regulation of the trypanosomatid signal recognition particle affects the biogenesis of polytopic membrane proteins but not of signal peptide-containing proteins

Lustig, Y., Vagima, Y., Goldshmidt, H., Erlanger, A., Ozeri, V., Vince, J., McConville, M. J., Dwyer, D. M., Landfear, S. M. & Michaeli, S., Oct 1 2007, In : Eukaryotic Cell. 6, 10, p. 1865-1875 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Molecular genetic analysis of purine nucleobase transport in Leishmania major

Ortiz, D., Sanchez, M. A., Pierce, S., Herrmann, T., Kimblin, N., Archie Bouwer, H. G. & Landfear, S. M., Jun 1 2007, In : Molecular Microbiology. 64, 5, p. 1228-1243 16 p.

Research output: Contribution to journalArticle

30 Scopus citations

Phenotypic characterization of a glucose transporter null mutant in Leishmania mexicana

Rodriguez-Contreras, D., Feng, X., Keeney, K. M., Bouwer, H. G. A. & Landfear, S. M., May 1 2007, In : Molecular and Biochemical Parasitology. 153, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2006

Comprehensive examination of charged intramembrane residues in a nucleoside transporter

Valdés, R., Liu, W., Ullman, B. & Landfear, S. M., Aug 11 2006, In : Journal of Biological Chemistry. 281, 32, p. 22647-22655 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid

Liu, Z., Sanchez, M. A., Jiang, X., Boles, E., Landfear, S. M. & Rosen, B. P., Dec 15 2006, In : Biochemical and Biophysical Research Communications. 351, 2, p. 424-430 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

Metabolic changes in glucose transporter-deficient Leishmania mexicana and parasite virulence

Rodríguez-Contreras, D. & Landfear, S. M., Jul 21 2006, In : Journal of Biological Chemistry. 281, 29, p. 20068-20076 9 p.

Research output: Contribution to journalArticle

38 Scopus citations
2005

The genome of the African trypanosome Trypanosoma brucei

Berriman, M., Ghedin, E., Hertz-Fowler, C., Blandin, G., Renauld, H., Bartholomeu, D. C., Lennard, N. J., Caler, E., Hamlin, N. E., Haas, B., Böhme, U., Hannick, L., Aslett, M. A., Shallom, J., Marcello, L., Hou, L., Wickstead, B., Alsmark, U. C. M., Arrowsmith, C., Atkin, R. J. & 82 others, Barron, A. J., Bringaud, F., Brooks, K., Carrington, M., Cherevach, I., Chillingworth, T. J., Churcher, C., Clark, L. N., Corton, C. H., Cronin, A., Davies, R. M., Doggett, J., Djikeng, A., Feldblyum, T., Field, M. C., Fraser, A., Goodhead, I., Hance, Z., Harper, D., Harris, B. R., Hauser, H., Hostetler, J., Ivens, A., Jagels, K., Johnson, D., Johnson, J., Jones, K., Kerhornou, A. X., Koo, H., Larke, N., Landfear, S., Larkin, C., Leech, V., Line, A., Lord, A., MacLeod, A., Mooney, P. J., Moule, S., Martin, D. M. A., Morgan, G. W., Mungall, K., Norbertczak, H., Ormond, D., Pai, G., Peacock, C. S., Peterson, J., Quail, M. A., Rabbinowitsch, E., Rajandream, M. A., Reitter, C., Salzberg, S. L., Sanders, M., Schobel, S., Sharp, S., Simmonds, M., Simpson, A. J., Tallon, L., Turner, C. M. R., Tait, A., Tivey, A. R., Van Aken, S., Walker, D., Wanless, D., Wang, S., White, B., White, O., Whitehead, S., Woodward, J., Wortman, J., Adams, M. D., Embley, T. M., Gull, K., Ullu, E., Barry, J. D., Fairlamb, A. H., Opperdoes, F., Barrell, B. G., Donelson, J. E., Hall, N., Fraser, C. M., Melville, S. E. & El-Sayed, N. M., Jul 15 2005, In : Science. 309, 5733, p. 416-422 7 p.

Research output: Contribution to journalArticle

1130 Scopus citations
2004

A novel purine nucleoside transporter whose expression is up-regulated in the short stumpy form of the Trypanosoma brucei life cycle

Sanchez, M. A., Drutman, S., Van Ampting, M., Matthews, K. & Landfear, S. M., Aug 1 2004, In : Molecular and Biochemical Parasitology. 136, 2, p. 265-272 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Functional expression and characterization of a purine nucleobase transporter gene from Leishmania major

Sanchez, M. A., Tryon, R., Pierce, S., Vasudevan, G. & Landfear, S. M., Jan 1 2004, In : Molecular Membrane Biology. 21, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Sequences required for the flagellar targeting of an integral membrane protein

Nasser, M. I. A. & Landfear, S. M., May 1 2004, In : Molecular and Biochemical Parasitology. 135, 1, p. 89-100 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Transmembrane domain 5 of the LdNT1.1 nucleoside transporter is an amphipathic helix that forms part of the nucleoside translocation pathway

Valdés, R., Vasudevan, G., Conklin, D. & Landfear, S. M., Jun 1 2004, In : Biochemistry. 43, 21, p. 6793-6802 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2003

Equilibrative nucleoside transporter family members from Leishmania donovani are electrogenic proton symporters

Stein, A., Vaseduvan, G., Carter, N. S., Ullman, B., Landfear, S. M. & Kavanaugh, M. P., Sep 12 2003, In : Journal of Biological Chemistry. 278, 37, p. 35127-35134 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Molecular and functional characterization of the first nucleobase transporter gene from African trypanosomes

Henriques, C., Sanchez, M. A., Tryon, R. & Landfear, S. M., Aug 31 2003, In : Molecular and Biochemical Parasitology. 130, 2, p. 101-110 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

The Adenosine Analog Tubercidin Inhibits Glycolysis in Trypanosoma brucei as Revealed by an RNA Interference Library

Drew, M. E., Morris, J. C., Wang, Z., Wells, L., Sanchez, M., Landfear, S. M. & Englund, P. T., Nov 21 2003, In : Journal of Biological Chemistry. 278, 47, p. 46596-46600 5 p.

Research output: Contribution to journalArticle

50 Scopus citations
2002

Six related nucleoside/nucleobase transporters from Trypanosoma brucei exhibit distinct biochemical functions

Sanchez, M. A., Tryon, R., Green, J., Boor, I. & Landfear, S. M., Jun 14 2002, In : Journal of Biological Chemistry. 277, 24, p. 21499-21504 6 p.

Research output: Contribution to journalArticle

49 Scopus citations
2001

Molecular genetics of nucleoside transporters in Leishmania and African trypanosomes

Landfear, S. M., Jul 15 2001, In : Biochemical Pharmacology. 62, 2, p. 149-155 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Nucleoside transporters of parasitic protozoa

Carter, N. S., Landfear, S. M. & Ullman, B., May 21 2001, In : Trends in Parasitology. 17, 3, p. 142-145 4 p.

Research output: Contribution to journalArticle

52 Scopus citations
53 Scopus citations
2000

Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant

Carter, N. S., Drew, M. E., Sanchez, M., Vasudevan, G., Landfear, S. M. & Ullman, B., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20935-20941 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Four conserved cytoplasmic sequence motifs are important for transport function of the Leishmania inositol/H+ symporter

Seyfang, A. & Landfear, S. M., Feb 25 2000, In : Journal of Biological Chemistry. 275, 8, p. 5687-5693 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Isolation and functional characterization of the PfNT1 nucleoside transporter gene from Plasmodium falciparum

Carter, N. S., Mamoun, C. B., Liu, W., Silva, E. O., Landfear, S. M., Goldberg, D. E. & Ullman, B., Apr 7 2000, In : Journal of Biological Chemistry. 275, 14, p. 10683-10691 9 p.

Research output: Contribution to journalArticle

108 Scopus citations