• 3995 Citations
  • 35 h-Index
1974 …2021
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Research Output 1974 2019

  • 3995 Citations
  • 35 h-Index
  • 97 Article
  • 3 Chapter
  • 1 Review article
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Article
2019

Sensing What's Out There – Kinetoplastid Parasites

Landfear, S. & Zilberstein, D., Jan 1 2019, (Accepted/In press) In : Trends in Parasitology.

Research output: Contribution to journalArticle

Parasites
Trypanosomiasis
Leishmania
Signal Transduction
Membrane Proteins
2018
2 Citations (Scopus)

Glucose Transporters and Virulence in Leishmania mexicana

Feng, X., Tran, K. D., Sanchez, M., Al Mezewghi, H. & Landfear, S., Aug 1 2018, In : mSphere. 3, 4

Research output: Contribution to journalArticle

Leishmania mexicana
Facilitative Glucose Transport Proteins
Virulence
Macrophages
Parasites
6 Citations (Scopus)

Leishmania mexicana can utilize amino acids as major carbon sources in macrophages but not in animal models

Saunders, E. C., Naderer, T., Chambers, J., Landfear, S. & Mcconville, M. J., Jan 1 2018, (Accepted/In press) In : Molecular Microbiology.

Research output: Contribution to journalArticle

Leishmania mexicana
Carbon
Animal Models
Macrophages
Amino Acids
2017
3 Citations (Scopus)

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening

Ortiz, D., Guiguemde, W. A., Hammill, J. T., Carrillo, A. K., Chen, Y., Connelly, M., Stalheim, K., Elya, C., Johnson, A., Min, J., Shelat, A., Smithson, D. C., Yang, L., Zhu, F., Guy, R. K. & Landfear, S., Dec 1 2017, In : PLoS Neglected Tropical Diseases. 11, 12, p. e0006157

Research output: Contribution to journalArticle

Parasitic Diseases
Leishmaniasis
miltefosine
Parasites
Pharmacokinetics
2016
3 Citations (Scopus)

KHARON is an essential cytoskeletal protein involved in the trafficking of flagellar membrane proteins and cell division in african trypanosomes

Sanchez, M., Tran, K. D., Valli, J., Hobbs, S., Johnson, E., Gluenz, E. & Landfear, S., Sep 16 2016, In : Journal of Biological Chemistry. 291, 38, p. 19760-19773 14 p.

Research output: Contribution to journalArticle

Cytoskeletal Proteins
Trypanosomiasis
Cell Division
Membrane Proteins
Parasites
88 Citations (Scopus)

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Van Voorhis, W. C., Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., Alano, P., Alday, A., Alemán Resto, Y., Alsibaee, A., Alzualde, A., Andrews, K. T., Avery, S. V., Avery, V. M., Ayong, L., Baker, M., Baker, S., Ben Mamoun, C., Bhatia, S., Bickle, Q., Bounaadja, L. & 167 others, Bowling, T., Bosch, J., Boucher, L. E., Boyom, F. F., Brea, J., Brennan, M., Burton, A., Caffrey, C. R., Camarda, G., Carrasquilla, M., Carter, D., Belen Cassera, M., Chih-Chien Cheng, K., Chindaudomsate, W., Chubb, A., Colon, B. L., Colón-López, D. D., Corbett, Y., Crowther, G. J., Cowan, N., D’Alessandro, S., Le Dang, N., Delves, M., DeRisi, J. L., Du, A. Y., Duffy, S., Abd El-Salam El-Sayed, S., Ferdig, M. T., Fernández Robledo, J. A., Fidock, D. A., Florent, I., Fokou, P. V. T., Galstian, A., Gamo, F. J., Gokool, S., Gold, B., Golub, T., Goldgof, G. M., Guha, R., Guiguemde, W. A., Gural, N., Guy, R. K., Hansen, M. A. E., Hanson, K. K., Hemphill, A., Hooft van Huijsduijnen, R., Horii, T., Horrocks, P., Hughes, T. B., Huston, C., Igarashi, I., Ingram-Sieber, K., Itoe, M. A., Jadhav, A., Naranuntarat Jensen, A., Jensen, L. T., Jiang, R. H. Y., Kaiser, A., Keiser, J., Ketas, T., Kicka, S., Kim, S., Kirk, K., Kumar, V. P., Kyle, D. E., Lafuente, M. J., Landfear, S., Lee, N., Lee, S., Lehane, A. M., Li, F., Little, D., Liu, L., Llinás, M., Loza, M. I., Lubar, A., Lucantoni, L., Lucet, I., Maes, L., Mancama, D., Mansour, N. R., March, S., McGowan, S., Medina Vera, I., Meister, S., Mercer, L., Mestres, J., Mfopa, A. N., Misra, R. N., Moon, S., Moore, J. P., Morais Rodrigues da Costa, F., Müller, J., Muriana, A., Nakazawa Hewitt, S., Nare, B., Nathan, C., Narraidoo, N., Nawaratna, S., Ojo, K. K., Ortiz, D., Panic, G., Papadatos, G., Parapini, S., Patra, K., Pham, N., Prats, S., Plouffe, D. M., Poulsen, S. A., Pradhan, A., Quevedo, C., Quinn, R. J., Rice, C. A., Abdo Rizk, M., Ruecker, A., St. Onge, R., Salgado Ferreira, R., Samra, J., Robinett, N. G., Schlecht, U., Schmitt, M., Silva Villela, F., Silvestrini, F., Sinden, R., Smith, D. A., Soldati, T., Spitzmüller, A., Stamm, S. M., Sullivan, D. J., Sullivan, W., Suresh, S., Suzuki, B. M., Suzuki, Y., Swamidass, S. J., Taramelli, D., Tchokouaha, L. R. Y., Theron, A., Thomas, D., Tonissen, K. F., Townson, S., Tripathi, A. K., Trofimov, V., Udenze, K. O., Ullah, I., Vallieres, C., Vigil, E., Vinetz, J. M., Voong Vinh, P., Vu, H., Watanabe, N. A., Weatherby, K., White, P. M., Wilks, A. F., Winzeler, E. A., Wojcik, E., Wree, M., Wu, W., Yokoyama, N., Zollo, P. H. A., Abla, N., Blasco, B., Burrows, J., Laleu, B., Leroy, D., Spangenberg, T., Wells, T. & Willis, P. A., Jul 1 2016, In : PLoS Pathogens. 12, 7, e1005763.

Research output: Contribution to journalArticle

Neglected Diseases
Drug Discovery
Malaria
Pharmaceutical Chemistry
Information Dissemination
12 Citations (Scopus)

Targeting the cytochrome bc1 complex of Leishmania parasites for discovery of novel drugs

Ortiz, D., Forquer, I., Boitz, J., Soysa, R., Elya, C., Fulwiler, A., Nilsen, A., Polley, T., Riscoe, M., Ullman, B. & Landfear, S., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4972-4982 11 p.

Research output: Contribution to journalArticle

Electron Transport Complex III
Leishmania
Quinolones
Drug Discovery
Parasites
2015
3 Citations (Scopus)

Flagellar membrane proteins in kinetoplastid parasites

Landfear, S., Tran, K. D. & Sanchez, M., Sep 1 2015, In : IUBMB Life. 67, 9, p. 668-676 9 p.

Research output: Contribution to journalArticle

Membrane Proteins
Parasites
Flagella
Membranes
Protozoa
13 Citations (Scopus)

Identification of selective inhibitors of the Plasmodium falciparum hexose transporter PfHT by screening focused libraries of anti-malarial compounds

Ortiz, D., Guiguemde, W. A., Johnson, A., Elya, C., Anderson, J., Clark, J., Connelly, M., Yang, L., Min, J., Sato, Y., Guy, R. K. & Landfear, S., Apr 20 2015, In : PLoS One. 10, 4, e0123598.

Research output: Contribution to journalArticle

Monosaccharide Transport Proteins
antimalarials
Antimalarials
Plasmodium falciparum
hexoses
6 Citations (Scopus)

Kharon1 null mutants of leishmania Mexicana are avirulent in mice and exhibit a cytokinesis defect within macrophages

Tran, K. D., Vieira, D. P., Sanchez, M., Valli, J., Gluenz, E. & Landfear, S., Aug 12 2015, In : PLoS One. 10, 8, e0134432.

Research output: Contribution to journalArticle

Leishmania mexicana
amastigotes
Cytokinesis
Macrophages
cytokinesis
15 Citations (Scopus)

Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: A potential glucose sensor

Rodriguez-Contreras, D., Aslan, H., Feng, X., Tran, K., Yates, P., Kamhawi, S. & Landfear, S., Jan 1 2015, In : FASEB Journal. 29, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

Glucose sensors
Facilitative Glucose Transport Proteins
Glucose
Parasites
Leishmania mexicana
2014
20 Citations (Scopus)

Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family

Valdés, R., Elferich, J., Shinde, U. & Landfear, S., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8799-8809 11 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Leishmania donovani
Conformations
Crystal structure
Physiological Phenomena
1 Citation (Scopus)

Transporters, channels and receptors in flagella

Rodriguez-Contreras, D. & Landfear, S., 2014, In : Channels (Austin, Tex.). 8, 6, p. 477-478 2 p.

Research output: Contribution to journalArticle

Flagella
2013
10 Citations (Scopus)

KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes

Tran, K. D., Rodriguez-Contreras, D., Vieira, D. P., Yates, P., David, L., Beatty, W., Elferich, J. & Landfear, S., Aug 2 2013, In : Journal of Biological Chemistry. 288, 31, p. 22721-22733 13 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Flagella
Membrane Proteins
Kinetoplastida
Parasites
8 Citations (Scopus)

'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana

Feng, X., Rodriguez-Contreras, D., Polley, T., Lye, L. F., Scott, D., Burchmore, R. J. S., Beverley, S. M. & Landfear, S., Jan 2013, In : Molecular Microbiology. 87, 2, p. 412-429 18 p.

Research output: Contribution to journalArticle

Monosaccharide Transport Proteins
Leishmania mexicana
Genetic Suppression
Parasites
Comparative Genomic Hybridization
2012
11 Citations (Scopus)

Both sequence and context are important for flagellar targeting of a glucose transporter

Tran, K. D., Rodriguez-Contreras, D., Shinde, U. & Landfear, S., Jul 15 2012, In : Journal of Cell Science. 125, 14, p. 3293-3298 6 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Membrane Proteins
Amino Acid Motifs
Flagella
Cilia
9 Citations (Scopus)

Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1)

Valdés, R., Shinde, U. & Landfear, S., Dec 28 2012, In : Journal of Biological Chemistry. 287, 53, p. 44036-44045 10 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Leishmania donovani
Cysteine
Nucleosides
Disulfides
2011
25 Citations (Scopus)

A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs

Blume, M., Hliscs, M., Rodriguez-Contreras, D., Sanchez, M., Landfear, S., Lucius, R., Matuschewski, K. & Gupta, N., Apr 2011, In : FASEB Journal. 25, 4, p. 1218-1229 12 p.

Research output: Contribution to journalArticle

Hexoses
Membrane Transport Proteins
Plasmodium
Antimalarials
Life Cycle Stages
10 Citations (Scopus)

Lysosomal degradation of Leishmania hexose and inositol transporters is regulated in a stage-, nutrient- and ubiquitin-dependent manner

Vince, J. E., Tull, D., Landfear, S. & McConville, M. J., Jun 2011, In : International Journal for Parasitology. 41, 7, p. 791-800 10 p.

Research output: Contribution to journalArticle

Monosaccharide Transport Proteins
Leishmania
Inositol
Ubiquitin
Hexoses
36 Citations (Scopus)

Nutrient transport and pathogenesis in selected parasitic protozoa

Landfear, S., Apr 2011, In : Eukaryotic Cell. 10, 4, p. 483-493 11 p.

Research output: Contribution to journalArticle

Parasites
Food
Membrane Transport Proteins
Purines
Hexoses
6 Citations (Scopus)

Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes

Feng, X., Feistel, T., Buffalo, C., McCormack, A., Kruvand, E., Rodriguez-Contreras, D., Akopyants, N. S., Umasankar, P. K., David, L., Jardim, A., Beverley, S. M. & Landfear, S., Jan 2011, In : Molecular and Biochemical Parasitology. 175, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Facilitative Glucose Transport Proteins
Messenger RNA
Parasites
Genes
2010
31 Citations (Scopus)

Adaptive responses to purine starvation in Leishmania donovani

Carter, N., Yates, P., Gessford, S. K., Galagan, S. R., Landfear, S. & Ullman, B., Oct 2010, In : Molecular Microbiology. 78, 1, p. 92-107 16 p.

Research output: Contribution to journalArticle

Leishmania donovani
Starvation
Purine Nucleosides
Purines
Parasites
10 Citations (Scopus)

Glucose transporters in parasitic protozoa.

Landfear, S., 2010, In : Methods in molecular biology (Clifton, N.J.). 637, p. 245-262 18 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Parasites
Leishmania
Malaria
Monosaccharide Transport Proteins
13 Citations (Scopus)

Purine restriction induces pronounced translational upregulation of the NT1 adenosine/pyrimidine nucleoside transporter in Leishmania major

Ortiz, D., Valdés, R., Sanchez, M., Hayenga, J., Elya, C., Detke, S. & Landfear, S., Oct 2010, In : Molecular Microbiology. 78, 1, p. 108-118 11 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Pyrimidine Nucleosides
Leishmania major
Purines
Adenosine
12 Citations (Scopus)

Transporters for drug delivery and as drug targets in parasitic protozoa

Landfear, S., Jan 2010, In : Clinical Pharmacology and Therapeutics. 87, 1, p. 122-125 4 p.

Research output: Contribution to journalArticle

Parasites
Membrane Transport Proteins
Pharmaceutical Preparations
Neglected Diseases
Essential Drugs
2009
17 Citations (Scopus)

Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana

Feng, X., Rodriguez-Contreras, D., Buffalo, C., Bouwer, H. G. A., Kruvand, E., Beverley, S. M. & Landfear, S., Jan 2009, In : Molecular Microbiology. 71, 2, p. 369-381 13 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Facilitative Glucose Transport Proteins
Monosaccharide Transport Proteins
Phenotype
Membrane Transport Proteins
20 Citations (Scopus)

An ab initio structural model of a nucleoside permease predicts functionally important residues

Valdés, R., Arastu-Kapur, S., Landfear, S. & Shinde, U., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 19067-19076 10 p.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Structural Models
Nucleosides
Substrate Specificity
Mutation
22 Citations (Scopus)

An acid-activated nucleobase transporter from Leishmania major

Ortiz, D., Sanchez, M., Koch, H. P., Larson, H. P. & Landfear, S., Jun 12 2009, In : Journal of Biological Chemistry. 284, 24, p. 16164-16169 6 p.

Research output: Contribution to journalArticle

Leishmania major
Macrophages
Adenine
Acids
Protozoa
50 Citations (Scopus)

Arsenic transport by zebrafish aquaglyceroporins

Hamdi, M., Sanchez, M., Beene, L. C., Liu, Q., Landfear, S., Rosen, B. P. & Liu, Z., Nov 25 2009, In : BMC Molecular Biology. 10, 104.

Research output: Contribution to journalArticle

Aquaglyceroporins
Arsenic
Zebrafish
Aptitude
Fishes
51 Citations (Scopus)

Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis

Blume, M., Rodriguez-Contreras, D., Landfear, S., Fleige, T., Soldati-Favre, D., Lucius, R. & Gupta, N., Aug 4 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 31, p. 12998-13003 6 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Toxoplasma
Glutamine
Glucose
Growth
20 Citations (Scopus)

Two novel nucleobase/pentamidine transporters from Trypanosoma brucei

Ortiz, D., Sanchez, M., Quecke, P. & Landfear, S., Feb 2009, In : Molecular and Biochemical Parasitology. 163, 2, p. 67-76 10 p.

Research output: Contribution to journalArticle

Pentamidine
Trypanosoma brucei brucei
Purine Nucleosides
Nucleoside Transport Proteins
African Trypanosomiasis
2008
9 Citations (Scopus)

An expression system to screen for inhibitors of parasite glucose transporters

Feistel, T., Hodson, C. A., Peyton, D. H. & Landfear, S., Nov 2008, In : Molecular and Biochemical Parasitology. 162, 1, p. 71-76 6 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Parasites
Leishmania mexicana
Trypanosoma brucei brucei
Plasmodium falciparum
22 Citations (Scopus)

Drugs and Transporters in Kinetoplastid Protozoa

Landfear, S., 2008, In : Advances in Experimental Medicine and Biology. 625, p. 22-32 11 p.

Research output: Contribution to journalArticle

Protozoa
Membrane Transport Proteins
Parasites
Pharmaceutical Preparations
Leishmania major
2007
13 Citations (Scopus)

Down-regulation of the trypanosomatid signal recognition particle affects the biogenesis of polytopic membrane proteins but not of signal peptide-containing proteins

Lustig, Y., Vagima, Y., Goldshmidt, H., Erlanger, A., Ozeri, V., Vince, J., McConville, M. J., Dwyer, D. M., Landfear, S. & Michaeli, S., Oct 2007, In : Eukaryotic Cell. 6, 10, p. 1865-1875 11 p.

Research output: Contribution to journalArticle

Signal Recognition Particle
Trypanosomatidae
Protein Sorting Signals
signal peptide
membrane proteins
29 Citations (Scopus)

Molecular genetic analysis of purine nucleobase transport in Leishmania major

Ortiz, D., Sanchez, M., Pierce, S., Herrmann, T., Kimblin, N., Archie Bouwer, H. G. & Landfear, S., Jun 2007, In : Molecular Microbiology. 64, 5, p. 1228-1243 16 p.

Research output: Contribution to journalArticle

Leishmania major
Membrane Transport Proteins
Molecular Biology
Purines
Adenine
29 Citations (Scopus)

Phenotypic characterization of a glucose transporter null mutant in Leishmania mexicana

Rodriguez-Contreras, D., Feng, X., Keeney, K. M., Bouwer, H. G. A. & Landfear, S., May 2007, In : Molecular and Biochemical Parasitology. 153, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Facilitative Glucose Transport Proteins
Hexoses
Protein Isoforms
Parasites
2006
2 Citations (Scopus)

Cell biology: When the tail wags the dog

Landfear, S., Mar 9 2006, In : Nature. 440, 7081, p. 153-154 2 p.

Research output: Contribution to journalArticle

science and technology
cell (biology)
dog
21 Citations (Scopus)

Comprehensive examination of charged intramembrane residues in a nucleoside transporter

Valdés, R., Liu, W., Ullman, B. & Landfear, S., Aug 11 2006, In : Journal of Biological Chemistry. 281, 32, p. 22647-22655 9 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Inosine
Membrane Transport Proteins
Nucleosides
Pyrimidine Nucleosides
81 Citations (Scopus)

Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid

Liu, Z., Sanchez, M., Jiang, X., Boles, E., Landfear, S. & Rosen, B. P., Dec 15 2006, In : Biochemical and Biophysical Research Communications. 351, 2, p. 424-430 7 p.

Research output: Contribution to journalArticle

Yeast
Arsenic
Yeasts
Arsenicals
Hexoses
37 Citations (Scopus)

Metabolic changes in glucose transporter-deficient Leishmania mexicana and parasite virulence

Rodríguez-Contreras, D. & Landfear, S., Jul 21 2006, In : Journal of Biological Chemistry. 281, 29, p. 20068-20076 9 p.

Research output: Contribution to journalArticle

Mannans
Facilitative Glucose Transport Proteins
Virulence
Parasites
Glycoconjugates
2005
1093 Citations (Scopus)

The genome of the African trypanosome Trypanosoma brucei

Berriman, M., Ghedin, E., Hertz-Fowler, C., Blandin, G., Renauld, H., Bartholomeu, D. C., Lennard, N. J., Caler, E., Hamlin, N. E., Haas, B., Böhme, U., Hannick, L., Aslett, M. A., Shallom, J., Marcello, L., Hou, L., Wickstead, B., Alsmark, U. C. M., Arrowsmith, C., Atkin, R. J. & 82 others, Barron, A. J., Bringaud, F., Brooks, K., Carrington, M., Cherevach, I., Chillingworth, T. J., Churcher, C., Clark, L. N., Corton, C. H., Cronin, A., Davies, R. M., Doggett, J., Djikeng, A., Feldblyum, T., Field, M. C., Fraser, A., Goodhead, I., Hance, Z., Harper, D., Harris, B. R., Hauser, H., Hostetler, J., Ivens, A., Jagels, K., Johnson, D., Johnson, J., Jones, K., Kerhornou, A. X., Koo, H., Larke, N., Landfear, S., Larkin, C., Leech, V., Line, A., Lord, A., MacLeod, A., Mooney, P. J., Moule, S., Martin, D. M. A., Morgan, G. W., Mungall, K., Norbertczak, H., Ormond, D., Pai, G., Peacock, C. S., Peterson, J., Quail, M. A., Rabbinowitsch, E., Rajandream, M. A., Reitter, C., Salzberg, S. L., Sanders, M., Schobel, S., Sharp, S., Simmonds, M., Simpson, A. J., Tallon, L., Turner, C. M. R., Tait, A., Tivey, A. R., Van Aken, S., Walker, D., Wanless, D., Wang, S., White, B., White, O., Whitehead, S., Woodward, J., Wortman, J., Adams, M. D., Embley, T. M., Gull, K., Ullu, E., Barry, J. D., Fairlamb, A. H., Opperdoes, F., Barrell, B. G., Donelson, J. E., Hall, N., Fraser, C. M., Melville, S. E. & El-Sayed, N. M., Jul 15 2005, In : Science. 309, 5733, p. 416-422 7 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Trypanosomiasis
Genome
Leishmania major
Pseudogenes
2004
21 Citations (Scopus)

A novel purine nucleoside transporter whose expression is up-regulated in the short stumpy form of the Trypanosoma brucei life cycle

Sanchez, M., Drutman, S., Van Ampting, M., Matthews, K. & Landfear, S., Aug 2004, In : Molecular and Biochemical Parasitology. 136, 2, p. 265-272 8 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Purine Nucleosides
Trypanosoma brucei brucei
Life Cycle Stages
Purines
31 Citations (Scopus)

Functional expression and characterization of a purine nucleobase transporter gene from Leishmania major

Sanchez, M., Tryon, R., Pierce, S., Vasudevan, G. & Landfear, S., Jan 2004, In : Molecular Membrane Biology. 21, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Leishmania major
Genes
Hypoxanthine
Xanthine
89 Citations (Scopus)

Nucleoside and nucleobase transporters in parasitic protozoa

Landfear, S., Ullman, B., Carter, N. & Sanchez, M., Apr 2004, In : Eukaryotic Cell. 3, 2, p. 245-254 10 p.

Research output: Contribution to journalArticle

Protozoan Proteins
Nucleoside Transport Proteins
adenosine monophosphate
Purines
nucleosides
24 Citations (Scopus)

Sequences required for the flagellar targeting of an integral membrane protein

Nasser, M. I. A. & Landfear, S., May 2004, In : Molecular and Biochemical Parasitology. 135, 1, p. 89-100 12 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Leishmania enriettii
Membrane Proteins
Membrane Transport Proteins
Amino Acid Sequence
33 Citations (Scopus)

Transmembrane domain 5 of the LdNT1.1 nucleoside transporter is an amphipathic helix that forms part of the nucleoside translocation pathway

Valdés, R., Vasudevan, G., Conklin, D. & Landfear, S., Jun 1 2004, In : Biochemistry. 43, 21, p. 6793-6802 10 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Nucleosides
Cysteine
Adenosine
Uridine
2003
40 Citations (Scopus)

Equilibrative nucleoside transporter family members from Leishmania donovani are electrogenic proton symporters

Stein, A., Vaseduvan, G., Carter, N., Ullman, B., Landfear, S. & Kavanaugh, M. P., Sep 12 2003, In : Journal of Biological Chemistry. 278, 37, p. 35127-35134 8 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Symporters
Leishmania donovani
Protons
Pyrimidine Nucleosides
Leishmania mexicana
Facilitative Glucose Transport Proteins
24 Citations (Scopus)

Molecular and functional characterization of the first nucleobase transporter gene from African trypanosomes

Henriques, C., Sanchez, M., Tryon, R. & Landfear, S., Aug 31 2003, In : Molecular and Biochemical Parasitology. 130, 2, p. 101-110 10 p.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Trypanosomiasis
Nucleoside Transport Proteins
Purine Nucleosides
Genes
49 Citations (Scopus)

The Adenosine Analog Tubercidin Inhibits Glycolysis in Trypanosoma brucei as Revealed by an RNA Interference Library

Drew, M. E., Morris, J. C., Wang, Z., Wells, L., Sanchez, M., Landfear, S. & Englund, P. T., Nov 21 2003, In : Journal of Biological Chemistry. 278, 47, p. 46596-46600 5 p.

Research output: Contribution to journalArticle

Tubercidin
Trypanosoma brucei brucei
Glycolysis
RNA Interference
Adenosine