• 3227 Citations
  • 28 h-Index
1983 …2021
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1983 2019

  • 3227 Citations
  • 28 h-Index
  • 77 Article
2019

Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials

Dodean, R. A., Kancharla, P., Li, Y., Melendez, V., Read, L., Bane, C. E., Vesely, B., Kreishman-Deitrick, M., Black, C., Li, Q., Sciotti, R. J., Olmeda, R., Luong, T. L., Gaona, H., Potter, B., Sousa, J., Marcsisin, S., Caridha, D., Xie, L., Vuong, C. & 19 others, Zeng, Q., Zhang, J., Zhang, P., Lin, H., Butler, K., Roncal, N., Gaynor-Ohnstad, L., Leed, S. E., Nolan, C., Huezo, S. J., Rasmussen, S. A., Stephens, M. T., Tan, J. C., Cooper, R. A., Smilkstein, M. J., Pou, S., Winter, R. W., Riscoe, M. & Kelly, J. X., Apr 11 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3475-3502 28 p.

Research output: Contribution to journalArticle

Acridones
Antimalarials
Malaria
Plasmodium berghei
Sporozoites

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

Smilkstein, M. J., Pou, S., Krollenbrock, A., Bleyle, L. A., Dodean, R. A., Frueh, L., Hinrichs, D. J., Li, Y., Martinson, T., Munar, M. Y., Winter, R. W., Bruzual, I., Whiteside, S., Nilsen, A., Koop, D., Kelly, J. X., Kappe, S. H. I., Wilder, B. K. & Riscoe, M., Aug 27 2019, In : Malaria Journal. 18, 1, 291.

Research output: Contribution to journalArticle

Open Access
Malaria
Prodrugs
Plasmodium yoelii
Pharmacokinetics
Sporozoites
3 Citations (Scopus)

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages

Ke, H., Ganesan, S. M., Dass, S., Morrisey, J. M., Pou, S., Nilsen, A., Riscoe, M., Mather, M. W. & Vaidya, A. B., Apr 1 2019, In : PloS one. 14, 4, e0214023.

Research output: Contribution to journalArticle

Open Access
NADH dehydrogenase
Plasmodium falciparum
Parasites
antimalarials
Blood
2018

Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols

Gimenez, V. M. M., Alvarenga, T. A., Groppo, M., Silva, M. L. A. E., Cunha, W. R., Januário, A. H., Smilkstein, M. J., Riscoe, M. & Pauletti, P. M., Jan 1 2018, (Accepted/In press) In : Brazilian Journal of Pharmacognosy.

Research output: Contribution to journalArticle

Anacardium
Phenols
Inhibitory Concentration 50
Anacardic Acids
Ethanol

Endochin-like quinolones exhibit promising efficacy against neospora caninum in vitro and in experimentally infected pregnant mice

Anghel, N., Balmer, V., Müller, J., Winzer, P., Aguado-Martinez, A., Roozbehani, M., Pou, S., Nilsen, A., Riscoe, M., Doggett, J. & Hemphill, A., Nov 19 2018, In : Frontiers in Veterinary Science. 5, NOV, 285.

Research output: Contribution to journalArticle

Neospora
quinolones
Neospora caninum
Quinolones
mice
4 Citations (Scopus)

Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis

McConnell, E. V., Bruzual, I., Pou, S., Winter, R., Dodean, R. A., Smilkstein, M. J., Krollenbrock, A., Nilsen, A., Zakharov, L. N., Riscoe, M. & Doggett, J., Jan 1 2018, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

Qi
4-Quinolones
Electron Transport Complex III
Toxoplasmosis
Quinolones
2017
7 Citations (Scopus)

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

Frueh, L., Li, Y., Mather, M. W., Li, Q., Pou, S., Nilsen, A., Winter, R. W., Forquer, I. P., Pershing, A. M., Xie, L. H., Smilkstein, M. J., Caridha, D., Koop, D., Campbell, R. F., Sciotti, R. J., Kreishman-Deitrick, M., Kelly, J. X., Vesely, B., Vaidya, A. B. & Riscoe, M., Oct 13 2017, In : ACS Infectious Diseases. 3, 10, p. 728-735 8 p.

Research output: Contribution to journalArticle

Prodrugs
Malaria
Esters
Pharmaceutical Preparations
Plasmodium yoelii
18 Citations (Scopus)

Arginase is essential for survival of Leishmania donovani promastigotes but not intracellular amastigotes

Boitz, J. M., Gilroy, C. A., Olenyik, T. D., Paradis, D., Perdeh, J., Dearman, K., Davis, M. J., Yates, P., Li, Y., Riscoe, M., Ullman, B. & Roberts, S. C., 2017, In : Infection and Immunity. 85, 1, e00554-16.

Research output: Contribution to journalArticle

Leishmania donovani
Arginase
Polyamines
Ornithine
Parasites
15 Citations (Scopus)

Genetic evidence for cytochrome b Qi site inhibition by 4(1H)-quinolone-3-diarylethers and antimycin in Toxoplasma gondii

Alday, P. H., Bruzual, I., Nilsen, A., Pou, S., Winter, R., Mamoun, C. B., Riscoe, M. & Doggett, J., Feb 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 2, e01866.

Research output: Contribution to journalArticle

4-Quinolones
Qi
Cytochromes b
Quinolones
Toxoplasma
2016
16 Citations (Scopus)

Atovaquone and ELQ-300 combination therapy as a novel dual-site cytochrome bc1 inhibition strategy for malaria

Stickles, A. M., Smilkstein, M. J., Morrisey, J. M., Li, Y., Forquer, I. P., Kelly, J. X., Pou, S., Winter, R. W., Nilsen, A., Vaidya, A. B. & Riscoe, M., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4853-4859 7 p.

Research output: Contribution to journalArticle

Atovaquone
Electron Transport Complex III
Quinolones
Malaria
Antimalarials
16 Citations (Scopus)

Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis

Foss, M. H., Pou, S., Davidson, P. M., Dunaj, J. L., Winter, R. W., Pou, S., Licon, M. H., Doh, J. K., Li, Y., Kelly, J. X., Dodean, R. A., Koop, D., Riscoe, M. & Purdy, G., Jul 8 2016, In : ACS Infectious Diseases. 2, 7, p. 500-508 9 p.

Research output: Contribution to journalArticle

Diamines
Mycobacterium tuberculosis
Pharmaceutical Preparations
Infection
Extensively Drug-Resistant Tuberculosis
22 Citations (Scopus)

Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone

Lawres, L. A., Garg, A., Kumar, V., Bruzual, I., Forquer, I. P., Renard, I., Virji, A. Z., Boulard, P., Rodriguez, E. X., Allen, A. J., Pou, S., Wegmann, K. W., Winter, R. W., Nilsen, A., Mao, J., Preston, D. A., Belperron, A. A., Bockenstedt, L. K., Hinrichs, D. J., Riscoe, M. & 2 others, Doggett, J. & Mamoun, C. B., 2016, In : Journal of Experimental Medicine. 213, 7, p. 1307-1318 12 p.

Research output: Contribution to journalArticle

Atovaquone
Babesiosis
Quinolones
Parasites
Prodrugs
12 Citations (Scopus)

Targeting the cytochrome bc1 complex of Leishmania parasites for discovery of novel drugs

Ortiz, D., Forquer, I., Boitz, J., Soysa, R., Elya, C., Fulwiler, A., Nilsen, A., Polley, T., Riscoe, M., Ullman, B. & Landfear, S., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4972-4982 11 p.

Research output: Contribution to journalArticle

Electron Transport Complex III
Leishmania
Quinolones
Drug Discovery
Parasites
2015
23 Citations (Scopus)

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria

Miley, G. P., Pou, S., Winter, R., Nilsen, A., Li, Y., Kelly, J. X., Stickles, A. M., Mather, M. W., Forquer, I. P., Pershing, A. M., White, K., Shackleford, D., Saunders, J., Chen, G., Ting, L. M., Kim, K., Zakharov, L. N., Donini, C., Burrows, J. N., Vaidya, A. B. & 2 others, Charman, S. A. & Riscoe, M., Sep 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 9, p. 5555-5560 6 p.

Research output: Contribution to journalArticle

Prodrugs
Malaria
Safety
Zygote
Carbonates
18 Citations (Scopus)

Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy

Stickles, A. M., Ting, L. M., Morrisey, J. M., Li, Y., Mather, M. W., Meermeier, E., Pershing, A. M., Forquer, I. P., Miley, G. P., Pou, S., Winter, R. W., Hinrichs, D. J., Kelly, J. X., Kim, K., Vaidya, A. B., Riscoe, M. & Nilsen, A., Jun 1 2015, In : American Journal of Tropical Medicine and Hygiene. 92, 6, p. 1195-1201 7 p.

Research output: Contribution to journalArticle

Electron Transport Complex III
Antimalarials
Malaria
Parasites
Atovaquone
22 Citations (Scopus)

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of plasmodium falciparum

Stickles, A. M., De Almeida, M. J., Morrisey, J. M., Sheridan, K. A., Forquer, I. P., Nilsen, A., Winter, R. W., Burrows, J. N., Fidock, D. A., Vaidya, A. B. & Riscoe, M., Apr 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 4, p. 1977-1982 6 p.

Research output: Contribution to journalArticle

Qi
Electron Transport Complex III
Quinolones
Plasmodium falciparum
Atovaquone
2014
58 Citations (Scopus)

Discovery, synthesis, and optimization of antimalarial 4(1 H)-quinolone-3-diarylethers

Nilsen, A., Miley, G. P., Forquer, I. P., Mather, M. W., Katneni, K., Li, Y., Pou, S., Pershing, A. M., Stickles, A. M., Ryan, E., Kelly, J. X., Doggett, J., White, K. L., Hinrichs, D. J., Winter, R. W., Charman, S. A., Zakharov, L. N., Bathurst, I., Burrows, J. N., Vaidya, A. B. & 1 others, Riscoe, M., May 8 2014, In : Journal of Medicinal Chemistry. 57, 9, p. 3818-3834 17 p.

Research output: Contribution to journalArticle

Quinolones
Antimalarials
Atovaquone
4-Quinolones
Falciparum Malaria
9 Citations (Scopus)

Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro

Janowsky, A., Eshleman, A. J., Johnson, R. A., Wolfrum, K. M., Hinrichs, D. J., Yang, J., Zabriskie, M., Smilkstein, M. J. & Riscoe, M., 2014, In : Psychopharmacology. 231, 14, p. 2771-2783 13 p.

Research output: Contribution to journalArticle

Neurotransmitter Transport Proteins
Mefloquine
Neurotransmitter Receptor
Hallucinogens
Chloroquine
2013
118 Citations (Scopus)

Quinolone-3-diarylethers: A new class of antimalarial drug

Nilsen, A., LaCrue, A. N., White, K. L., Forquer, I. P., Cross, R. M., Marfurt, J., Mather, M. W., Delves, M. J., Shackleford, D. M., Saenz, F. E., Morrisey, J. M., Steuten, J., Mutka, T., Li, Y., Wirjanata, G., Ryan, E., Duffy, S., Kelly, J. X., Sebayang, B. F., Zeeman, A. M. & 21 others, Noviyanti, R., Sinden, R. E., Kocken, C. H. M., Price, R. N., Avery, V. M., Angulo-Barturen, I., Jiménez-Díaz, M. B., Ferrer, S., Herreros, E., Sanz, L. M., Gamo, F. J., Bathurst, I., Burrows, J. N., Siegl, P., Guy, R. K., Winter, R. W., Vaidya, A. B., Charman, S. A., Kyle, D. E., Manetsch, R. & Riscoe, M., Mar 20 2013, In : Science Translational Medicine. 5, 177, 177ra37.

Research output: Contribution to journalArticle

Quinolones
Antimalarials
Parasites
Malaria
4-Quinolones
8 Citations (Scopus)

Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of leishmania donovani pyrimidine auxotrophs

Soysa, R., Wilson, Z. N., Elferich, J., Forquer, I., Shinde, U., Riscoe, M., Yates, P. & Ullman, B., Oct 11 2013, In : Journal of Biological Chemistry. 288, 41, p. 29954-29964 11 p.

Research output: Contribution to journalArticle

uracil phosphoribosyltransferase
Leishmania donovani
Uracil
Salvaging
Substrates
2012
72 Citations (Scopus)

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

Doggett, J., Nilsen, A., Forquer, I., Wegmann, K. W., Jones-Brando, L., Yolken, R. H., Bordón, C., Charman, S. A., Katneni, K., Schultz, T., Burrows, J. N., Hinrichs, D. J., Meunier, B., Carruthers, V. B. & Riscoe, M., Sep 25 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 39, p. 15936-15941 6 p.

Research output: Contribution to journalArticle

Toxoplasmosis
Quinolones
Toxoplasma
Qi
Electron Transport Complex III
9 Citations (Scopus)

Sontochin as a guide to the development of drugs against chloroquine-resistant malaria

Pou, S., Winter, R. W., Nilsen, A., Kelly, J. X., Li, Y., Doggett, J., Riscoe, E. W., Wegmann, K. W., Hinrichs, D. J. & Riscoe, M., Jul 2012, In : Antimicrobial Agents and Chemotherapy. 56, 7, p. 3475-3480 6 p.

Research output: Contribution to journalArticle

Chloroquine
Malaria
Pharmaceutical Preparations
Plasmodium yoelii
Poisons
2011
47 Citations (Scopus)

Optimization of endochin-like quinolones for antimalarial activity

Winter, R., Kelly, J. X., Smilkstein, M. J., Hinrichs, D., Koop, D. & Riscoe, M., Feb 2011, In : Experimental Parasitology. 127, 2, p. 545-551 7 p.

Research output: Contribution to journalArticle

Quinolones
Antimalarials
Acridones
Atovaquone
Plasmodium falciparum
2010
391 Citations (Scopus)

Chemical genetics of Plasmodium falciparum

Guiguemde, W. A., Shelat, A. A., Bouck, D., Duffy, S., Crowther, G. J., Davis, P. H., Smithson, D. C., Connelly, M., Clark, J., Zhu, F., Jiménez-Díaz, M. B., Martinez, M. S., Wilson, E. B., Tripathi, A. K., Gut, J., Sharlow, E. R., Bathurst, I., Mazouni, F. E., Fowble, J. W., Forquer, I. & 15 others, McGinley, P. L., Castro, S., Angulo-Barturen, I., Ferrer, S., Rosenthal, P. J., Derisi, J. L., Sullivan, D. J., Lazo, J. S., Roos, D. S., Riscoe, M., Phillips, M. A., Rathod, P. K., Van Voorhis, W. C., Avery, V. M. & Guy, R. K., May 20 2010, In : Nature. 465, 7296, p. 311-315 5 p.

Research output: Contribution to journalArticle

Antimalarials
Plasmodium falciparum
Reverse Genetics
Falciparum Malaria
Toxoplasma
2009
131 Citations (Scopus)

Discovery of dual function acridones as a new antimalarial chemotype

Kelly, J. X., Smilkstein, M. J., Brun, R., Wittlin, S., Cooper, R. A., Lane, K. D., Janowsky, A., Johnson, R. A., Dodean, R. A., Winter, R., Hinrichs, D. J. & Riscoe, M., May 14 2009, In : Nature. 459, 7244, p. 270-273 4 p.

Research output: Contribution to journalArticle

Acridones
Antimalarials
Parasites
Heme
Pharmaceutical Preparations
9 Citations (Scopus)

Silicate Nephrolithiasis After Ingestion of Supplements Containing Silica Dioxide

Flythe, J. E., Rueda, J., Riscoe, M. & Watnick, S., Jul 2009, In : American Journal of Kidney Diseases. 54, 1, p. 127-130 4 p.

Research output: Contribution to journalArticle

Silicates
Nephrolithiasis
Silicon Dioxide
Eating
Calculi
2008
23 Citations (Scopus)

A drug-selected Plasmodium falciparum lacking the need for conventional electron transport

Smilkstein, M. J., Forquer, I., Kanazawa, A., Kelly, J. X., Winter, R. W., Hinrichs, D. J., Kramer, D. M. & Riscoe, M., May 2008, In : Molecular and Biochemical Parasitology. 159, 1, p. 64-68 5 p.

Research output: Contribution to journalArticle

Electron Transport Complex III
Plasmodium falciparum
Electron Transport
Pharmaceutical Preparations
Antimalarials
108 Citations (Scopus)

Antimalarial quinolones: Synthesis, potency, and mechanistic studies

Winter, R. W., Kelly, J. X., Smilkstein, M. J., Dodean, R., Hinrichs, D. & Riscoe, M., Apr 2008, In : Experimental Parasitology. 118, 4, p. 487-497 11 p.

Research output: Contribution to journalArticle

Atovaquone
Quinolones
Antimalarials
Parasites
Electron Transport Complex III
18 Citations (Scopus)

Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(ω-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone

Dodean, R. A., Kelly, J. X., Peyton, D., Gard, G. L., Riscoe, M. & Winter, R. W., Feb 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 3, p. 1174-1183 10 p.

Research output: Contribution to journalArticle

Antimalarials
Heme
Nuclear magnetic resonance
Drug interactions
Fluorine
4 Citations (Scopus)

White thrombus formation in blood tubing lines in a chronic hemodialysis unit

Watnick, S., Stooksbury, M., Winter, R., Riscoe, M. & Cohen, D., Mar 2008, In : Clinical Journal of the American Society of Nephrology. 3, 2, p. 382-386 5 p.

Research output: Contribution to journalArticle

Renal Dialysis
Thrombosis
Dialysis
Vascular Access Devices
United States Department of Veterans Affairs
2007
50 Citations (Scopus)

Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum

Kelly, J. X., Smilkstein, M. J., Cooper, R. A., Lane, K. D., Johnson, R. A., Janowsky, A., Dodean, R. A., Hinrichs, D. J., Winter, R. & Riscoe, M., Nov 2007, In : Antimicrobial Agents and Chemotherapy. 51, 11, p. 4133-4140 8 p.

Research output: Contribution to journalArticle

Acridones
Chloroquine
Plasmodium falciparum
Parasites
Quinine
6 Citations (Scopus)

Selective killing of the human malaria parasite Plasmodium falciparum by a benzylthiazolium dye

Kelly, J. X., Winter, R. W., Braun, T. P., Osei-Agyemang, M., Hinrichs, D. J. & Riscoe, M., Jun 2007, In : Experimental Parasitology. 116, 2, p. 103-110 8 p.

Research output: Contribution to journalArticle

Falciparum Malaria
Anions
Parasites
Coloring Agents
Plasmodium
14 Citations (Scopus)

Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of nucleotide binding

Ku, S. Y., Yip, P., Cornell, K. A., Riscoe, M., Behr, J. B., Guillerm, G. & Howell, P. L., Jul 27 2007, In : Journal of Biological Chemistry. 282, 30, p. 22195-22206 12 p.

Research output: Contribution to journalArticle

Substrate Specificity
Protein Kinases
Salvaging
Phosphotransferases
Nucleotides
2006
104 Citations (Scopus)

A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum

Burgess, S. J., Selzer, A., Kelly, J. X., Smilkstein, M. J., Riscoe, M. & Peyton, D. H., Sep 7 2006, In : Journal of Medicinal Chemistry. 49, 18, p. 5623-5625 3 p.

Research output: Contribution to journalArticle

Chloroquine
Plasmodium falciparum
Molecules
Diamines
Toxicity
69 Citations (Scopus)

Evaluation and lead optimization of anti-malarial acridones

Winter, R. W., Kelly, J. X., Smilkstein, M. J., Dodean, R., Bagby, G. C., Rathbun, R. K., Levin, J. I., Hinrichs, D. & Riscoe, M., Sep 2006, In : Experimental Parasitology. 114, 1, p. 47-56 10 p.

Research output: Contribution to journalArticle

Acridones
Antimalarials
Plasmodium
Electron Transport Complex III
Structure-Activity Relationship
2005
24 Citations (Scopus)

Mutational analysis of a nucleosidase involved in quorum-sensing autoinducer-2 biosynthesis

Lee, J. E., Luong, W., Huang, D. J. T., Cornell, K. A., Riscoe, M. & Howell, P. L., Aug 23 2005, In : Biochemistry. 44, 33, p. 11049-11057 9 p.

Research output: Contribution to journalArticle

adenosylhomocysteine nucleosidase
N-Glycosyl Hydrolases
Quorum Sensing
Mutagenesis
Biosynthesis
66 Citations (Scopus)

Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5′-methylthioadenosine/S- adenosylhomocysteine nucleosidase

Lee, J. E., Singh, V., Evans, G. B., Tyler, P. C., Furneax, R. H., Cornell, K. A., Riscoe, M., Schramm, V. L. & Howell, P. L., May 6 2005, In : Journal of Biological Chemistry. 280, 18, p. 18274-18282 9 p.

Research output: Contribution to journalArticle

adenosylhomocysteine nucleosidase
Escherichia coli
Purine-Nucleoside Phosphorylase
Ions
Atoms
29 Citations (Scopus)

Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis

Lee, J. E., Smith, G. D., Horvatin, C., Huang, D. J. T., Cornell, K. A., Riscoe, M. & Howell, P. L., Sep 23 2005, In : Journal of Molecular Biology. 352, 3, p. 559-574 16 p.

Research output: Contribution to journalArticle

adenosylhomocysteine nucleosidase
Pemetrexed
N-Glycosyl Hydrolases
Catalysis
Nucleosides
79 Citations (Scopus)

Xanthones as antimalarial agents: Discovery, mode of action, and optimization

Riscoe, M., Kelly, J. X. & Winter, R., 2005, In : Current Medicinal Chemistry. 12, 21, p. 2539-2549 11 p.

Research output: Contribution to journalArticle

Xanthones
Tropics
Antimalarials
Malaria
Protozoa
2004
10 Citations (Scopus)

Crystallization and preliminary X-ray analysis of 5′-methylthioribose kinase from Bacillus subtilis and Arabidopsis thaliana

Ku, S. Y., Yip, P., Cornell, K. A., Riscoe, M. & Howell, P. L., Jan 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 1, p. 116-119 4 p.

Research output: Contribution to journalArticle

Bacillus
X ray analysis
Bacilli
Crystallization
Bacillus subtilis
2 Citations (Scopus)

CyQUANT cell proliferation assay as a fluorescence-based method for in vitro screening of antimalarial activity

Sriwilaijaroen, N., Kelly, J. X., Riscoe, M. & Wilairat, P., Dec 2004, In : Southeast Asian Journal of Tropical Medicine and Public Health. 35, 4, p. 840-844 5 p.

Research output: Contribution to journalArticle

Antimalarials
Fluorescence
Cell Proliferation
Ethanolamine
Chloroquine
581 Citations (Scopus)

Simple and Inexpensive Fluorescence-Based Technique for High-Throughput Antimalarial Drug Screening

Smilkstein, M., Sriwilaijaroen, N., Kelly, J. X., Wilairat, P. & Riscoe, M., May 2004, In : Antimicrobial Agents and Chemotherapy. 48, 5, p. 1803-1806 4 p.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Antimalarials
Fluorescence
Parasites
Equipment Safety
28 Citations (Scopus)

Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design

Lee, J. E., Settembre, E. C., Cornell, K. A., Riscoe, M., Sufrin, J. R., Ealick, S. E. & Howell, P. L., May 11 2004, In : Biochemistry. 43, 18, p. 5159-5169 11 p.

Research output: Contribution to journalArticle

adenosylhomocysteine nucleosidase
Pemetrexed
N-Glycosyl Hydrolases
Substrates
Phosphorylases
49 Citations (Scopus)

α lipoic acid inhibits human T-cell migration: Implications for multiple sclerosis

Marracci, G., McKeon, G. P., Marquardt, W. E., Winter, R. W., Riscoe, M. & Bourdette, D., Nov 1 2004, In : Journal of Neuroscience Research. 78, 3, p. 362-370 9 p.

Research output: Contribution to journalArticle

Thioctic Acid
Oxidants
Multiple Sclerosis
Cell Movement
Jurkat Cells
2003
17 Citations (Scopus)

Antileishmanial drug development: Exploitation of parasite heme dependency

Kelly, J. X., Ignatushchenko, M. V., Bouwer, H. G., Peyton, D. H., Hinrichs, D. J., Winter, R. W. & Riscoe, M., Jan 2003, In : Molecular and Biochemical Parasitology. 126, 1, p. 43-49 7 p.

Research output: Contribution to journalArticle

Heme
Parasites
Xanthones
Pharmaceutical Preparations
Leishmania
48 Citations (Scopus)
adenosylhomocysteine nucleosidase
Catalysis
Escherichia coli
Substrates
Adenine
2002
59 Citations (Scopus)

Optimization of xanthones for antimalarial activity: The 3,6-bis-ω-diethylaminoalkoxyxanthone series

Kelly, J. X., Winter, R., Peyton, D. H., Hinrichs, D. J. & Riscoe, M., 2002, In : Antimicrobial Agents and Chemotherapy. 46, 1, p. 144-150 7 p.

Research output: Contribution to journalArticle

Xanthones
Antimalarials
Heme
Chloroquine
Inhibitory Concentration 50
17 Citations (Scopus)

The kinetics of uptake and accumulation of 3,6-bis-ω-diethylamino-amyloxyxanthone by the human malaria parasite Plasmodium falciparum

Kelly, J. X., Winter, R. W., Cornea, A., Peyton, D. H., Hinrichs, D. J. & Riscoe, M., Aug 7 2002, In : Molecular and Biochemical Parasitology. 123, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

Falciparum Malaria
Heme
Parasites
Vacuoles
Pharmaceutical Preparations
2001
38 Citations (Scopus)

A spectroscopic investigation of the binding interactions between 4,5-dihydroxyxanthone and heme

Xu Kelly, J., Winter, R., Riscoe, M. & Peyton, D. H., 2001, In : Journal of Inorganic Biochemistry. 86, 2-3, p. 617-625 9 p.

Research output: Contribution to journalArticle

Heme
Parasites
Nuclear magnetic resonance
Plasmodium malariae
Xanthones
27 Citations (Scopus)
adenosylhomocysteine nucleosidase
x ray analysis
Diamond
Escherichia
Crystallization