Projects per year
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- 2 Similar Profiles
Antimalarials
Medicine & Life Sciences
adenosylhomocysteine nucleosidase
Medicine & Life Sciences
Quinolones
Medicine & Life Sciences
Parasites
Medicine & Life Sciences
Plasmodium falciparum
Medicine & Life Sciences
Pharmaceutical Preparations
Medicine & Life Sciences
Electron Transport Complex III
Medicine & Life Sciences
Malaria
Medicine & Life Sciences
Network
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Projects 2003 2021
Design and Optimization of Novel Antimalarial Drugs
4/1/16 → 3/31/21
Project: Research project › Non-HHS Research Projects
Antimalarials
Malaria
Multiple Drug Resistance
Chloroquine
Amodiaquine
ShEEP Request for Parkin-Elmer Spectrum Series Bio-imaging Device
5/1/16 → 9/30/16
Project: Research project
Equipment and Supplies
Research
Health Services Research
Delivery of Health Care
Arthritis
Optimizing ELQs for Treatment and Prevention of Malaria
7/1/12 → 11/30/17
Project: Research project › High Priority, Short Term Project Award, Research Project
Quinolones
Malaria
Sporozoites
Parasites
Antimalarials
Optimizing Pharmachins for Treatment and Prevention of Drug Resistant Malaria
1/1/12 → 12/31/15
Project: Research project › Non-HHS Research Projects
Malaria
Pharmaceutical Preparations
Parasites
Chloroquine
Therapeutics
Development of a Chloroquine Replacement Drug
9/25/09 → 8/31/12
Project: Research project › NIH Challenge Grants and Partnerships Program
Chloroquine
Malaria
Pharmaceutical Preparations
Mefloquine
Quinine
Research Output 1983 2018
- 3005 Citations
- 28 h-Index
- 72 Article
1
Citations
Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis
McConnell, E. V., Bruzual, I., Pou, S., Winter, R., Dodean, R. A., Smilkstein, M. J., Krollenbrock, A., Nilsen, A., Zakharov, L. N., Riscoe, M. & Doggett, J., Jan 1 2018, (Accepted/In press) In : ACS Infectious Diseases.Research output: Contribution to journal › Article
Qi
4-Quinolones
Electron Transport Complex III
Toxoplasmosis
Quinolones
4
Citations
Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria
Frueh, L., Li, Y., Mather, M. W., Li, Q., Pou, S., Nilsen, A., Winter, R. W., Forquer, I. P., Pershing, A. M., Xie, L. H., Smilkstein, M. J., Caridha, D., Koop, D. R., Campbell, R. F., Sciotti, R. J., Kreishman-Deitrick, M., Kelly, J. X., Vesely, B., Vaidya, A. B. & Riscoe, M. K., Oct 13 2017, In : ACS Infectious Diseases. 3, 10, p. 728-735 8 p.Research output: Contribution to journal › Article
Prodrugs
Malaria
Esters
Pharmaceutical Preparations
Plasmodium yoelii
13
Citations
Arginase is essential for survival of Leishmania donovani promastigotes but not intracellular amastigotes
Boitz, J. M., Gilroy, C. A., Olenyik, T. D., Paradis, D., Perdeh, J., Dearman, K., Davis, M. J., Yates, P. A., Li, Y., Riscoe, M. K., Ullman, B. & Roberts, S. C., 2017, In : Infection and Immunity. 85, 1, e00554-16.Research output: Contribution to journal › Article
Leishmania donovani
Arginase
Polyamines
Ornithine
Parasites
9
Citations
Genetic evidence for cytochrome b Qi site inhibition by 4(1H)-quinolone-3-diarylethers and antimycin in Toxoplasma gondii
Alday, P. H., Bruzual, I., Nilsen, A., Pou, S., Winter, R., Mamoun, C. B., Riscoe, M. K. & Doggett, J. S., Feb 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 2, e01866.Research output: Contribution to journal › Article
4-Quinolones
Qi
Cytochromes b
Quinolones
Toxoplasma
8
Citations
Atovaquone and ELQ-300 combination therapy as a novel dual-site cytochrome bc1 inhibition strategy for malaria
Stickles, A. M., Smilkstein, M. J., Morrisey, J. M., Li, Y., Forquer, I. P., Kelly, J. X., Pou, S., Winter, R. W., Nilsen, A., Vaidya, A. B. & Riscoe, M. K., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4853-4859 7 p.Research output: Contribution to journal › Article
Atovaquone
Electron Transport Complex III
Quinolones
Malaria
Antimalarials