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  • 4 Similar Profiles
Antimalarials Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Parasites Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Quinolones Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences
adenosylhomocysteine nucleosidase Medicine & Life Sciences
Malaria Medicine & Life Sciences

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Projects 2003 2021

Design and Optimization of Novel Antimalarial Drugs

Riscoe, M.

National Institutes of Health

4/1/163/31/21

Project: Research projectNon-HHS Research Projects

Antimalarials
Malaria
Multiple Drug Resistance
Pharmaceutical Preparations
Therapeutics
Equipment and Supplies
Research
Therapeutics
Delivery of Health Care
Neoplasms

Optimizing ELQs for Treatment and Prevention of Malaria

Riscoe, M.

National Institutes of Health

7/1/1211/30/17

Project: Research projectHigh Priority, Short Term Project Award, Research Project

Quinolones
Malaria
Therapeutics
Parasites
Liver
Malaria
Pharmaceutical Preparations
Therapeutics
Parasites
Chloroquine

Development of a Chloroquine Replacement Drug

Riscoe, M.

National Institutes of Health

9/25/098/31/12

Project: Research projectNIH Challenge Grants and Partnerships Program

Chloroquine
Malaria
Pharmaceutical Preparations
Mefloquine
Quinine

Research Output 1983 2017

  • 2695 Citations
  • 28 h-Index
  • 71 Article

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

Frueh, L., Li, Y., Mather, M. W., Li, Q., Pou, S., Nilsen, A., Winter, R. W., Forquer, I. P., Pershing, A. M., Xie, L. H., Smilkstein, M. J., Caridha, D., Koop, D. R., Campbell, R. F., Sciotti, R. J., Kreishman-Deitrick, M., Kelly, J. X., Vesely, B., Vaidya, A. B. & Riscoe, M. K. Oct 13 2017 In : ACS Infectious Diseases. 3, 10, p. 728-735 8 p.

Research output: Research - peer-reviewArticle

Prodrugs
Malaria
Esters
Pharmaceutical Preparations
6-Chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one
5 Citations

Arginase is essential for survival of Leishmania donovani promastigotes but not intracellular amastigotes

Boitz, J. M., Gilroy, C. A., Olenyik, T. D., Paradis, D., Perdeh, J., Dearman, K., Davis, M. J., Yates, P. A., Li, Y., Riscoe, M. K., Ullman, B. & Roberts, S. C. 2017 In : Infection and Immunity. 85, 1, e00554-16

Research output: Research - peer-reviewArticle

Leishmania donovani
Arginase
Polyamines
Parasites
Ornithine

Genetic evidence for cytochrome b Qi site inhibition by 4(1H)-quinolone-3-diarylethers and antimycin in Toxoplasma gondii

Alday, P. H., Bruzual, I., Nilsen, A., Pou, S., Winter, R., Mamoun, C. B., Riscoe, M. K. & Doggett, J. S. Feb 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 2, e01866

Research output: Research - peer-reviewArticle

4-Quinolones
Cytochromes b
Quinolones
Toxoplasma
antimycin
4 Citations

Atovaquone and ELQ-300 combination therapy as a novel dual-site cytochrome bc1 inhibition strategy for malaria

Stickles, A. M., Smilkstein, M. J., Morrisey, J. M., Li, Y., Forquer, I. P., Kelly, J. X., Pou, S., Winter, R. W., Nilsen, A., Vaidya, A. B. & Riscoe, M. K. Aug 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4853-4859 7 p.

Research output: Research - peer-reviewArticle

Atovaquone
Quinolones
Cytochromes
Malaria
Therapeutics
8 Citations

Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis

Foss, M. H., Pou, S., Davidson, P. M., Dunaj, J. L., Winter, R. W., Pou, S., Licon, M. H., Doh, J. K., Li, Y., Kelly, J. X., Dodean, R. A., Koop, D. R., Riscoe, M. K. & Purdy, G. E. Jul 8 2016 In : ACS Infectious Diseases. 2, 7, p. 500-508 9 p.

Research output: Research - peer-reviewArticle

Diamines
Mycobacterium tuberculosis
Pharmaceutical Preparations
Infection
Bacteria