Joseph Aslan

Assistant Professor

  • 942 Citations
  • 16 h-Index
20052019
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Research Output 2005 2019

2019

ELMO1 deficiency enhances platelet function

Patel, A., Kostyak, J., Dangelmaier, C., Badolia, R., Bhavanasi, D., Aslan, J., Merali, S., Kim, S., Eble, J. A., Goldfinger, L. & Kunapuli, S., Feb 26 2019, In : Blood advances. 3, 4, p. 575-587 13 p.

Research output: Contribution to journalArticle

Cell Movement
Blood Platelets
Glycoproteins
Thrombosis
Integrins

Identification, Quantification, and System Analysis of Protein N-ε Lysine Methylation in Anucleate Blood Platelets

Rocheleau, A. D., Melrose, A. R., Cunliffe, J. M., Klimek, J., Babur, O., Tassi Yunga, S., Ngo, A. T. P., Pang, J., David, L., McCarty, O. & Aslan, J., Jan 1 2019, In : Proteomics. 1900001.

Research output: Contribution to journalArticle

Methylation
Platelets
Systems Analysis
Lysine
Identification (control systems)
3 Citations (Scopus)

Platelet Rho GTPase regulation in physiology and disease

Aslan, J., Jan 2 2019, In : Platelets. 30, 1, p. 17-22 6 p.

Research output: Contribution to journalReview article

rho GTP-Binding Proteins
Blood Platelets
Guanine Nucleotide Dissociation Inhibitors
GTPase-Activating Proteins
Platelet Activation
2018

Bleeding TAPs out

Ngo, A. T. P., Aslan, J. & McCarty, O., Jan 1 2018, (Accepted/In press) In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Hemorrhage
3 Citations (Scopus)

Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis

Babur, O., Ngo, A. T. P., Rigg, R. A., Pang, J., Rub, Z. T., Buchanan, A. E., Mitrugno, A., David, L., McCarty, O., Demir, E. & Aslan, J., May 1 2018, In : American journal of physiology. Cell physiology. 314, 5, p. C603-C615

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Blood Platelets
Phenotype
Hemostatics
Systems Biology

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Rigg, R. A., Healy, L. D., Chu, T. T., Ngo, A. T. P., Mitrugno, A., Zilberman-Rudenko, J., Aslan, J., Hinds, M., Vecchiarelli, L. D., Morgan, T., Gruber, A., Temple, K. J., Lindsley, C. W., Duvernay, M. T., Hamm, H. E. & McCarty, O., Jan 1 2018, (Accepted/In press) In : Platelets.

Research output: Contribution to journalArticle

Leukocytes
Blood Platelets
Cathepsin G
Fibrinolysin
Platelet Activation
Calcium-Sensing Receptors
Type C Phospholipases
Blood Platelets
Calcium
2017
6 Citations (Scopus)

Assessment of roles for the rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: A spatial systems approach

Ngo, A. T. P., Thierheimer, M. L. D., Babur, O., Rocheleau, A. D., Huang, T., Pang, J., Rigg, R. A., Mitrugno, A., Theodorescu, D., Burchard, J., Nan, X., Demir, E., McCarty, O. & Aslan, J., Apr 7 2017, In : American Journal of Physiology - Cell Physiology. 312, 4, p. C527-C536

Research output: Contribution to journalArticle

rho-Specific Guanine Nucleotide Dissociation Inhibitors
Guanine Nucleotide Dissociation Inhibitors
Systems Analysis
Blood Platelets
Protein Kinase C
8 Citations (Scopus)

Caught in the act -protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease

Thomas, G., Aslan, J., Thomas, L., Shinde, P., Shinde, U. & Simmen, T., Jun 1 2017, In : Journal of Cell Science. 130, 11, p. 1865-1876 12 p.

Research output: Contribution to journalComment/debate

Homeostasis
Vertebrates
Proteins
Cell Physiological Phenomena
Communication
4 Citations (Scopus)

Platelet shape change

Aslan, J., Mar 8 2017, Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Springer International Publishing, p. 321-336 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Platelets
Blood Platelets
Platelet Activation
Chemical activation
Actomyosin

Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395

Mitrugno, A., Rigg, R. A., Laschober, N. B., Ngo, A. T. P., Pang, J., Williams, C. D., Aslan, J. & McCarty, O., May 20 2017, (Accepted/In press) In : Platelets. p. 1-12 12 p.

Research output: Contribution to journalArticle

Blood Platelets
thrombin receptor peptide SFLLRNP
Hemostatics
Adenosine Diphosphate
Phosphorylation
2016
8 Citations (Scopus)

Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation

Rigg, R. A., Healy, L. D., Nowak, M. S., Mallet, J., Thierheimer, M. L. D., Pang, J., McCarty, O. & Aslan, J., Apr 1 2016, In : American Journal of Physiology - Cell Physiology. 310, 7, p. C568-C575

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Platelet Activation
Integrins
Blood Platelets
Glycoproteins
27 Citations (Scopus)

Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function

Rigg, R. A., Aslan, J., Healy, L. D., Wallisch, M., Thierheimer, M. L. D., Loren, C. P., Pang, J., Hinds, M., Gruber, A. & McCarty, O., Mar 1 2016, In : American Journal of Physiology - Cell Physiology. 310, 5, p. C373-C380

Research output: Contribution to journalArticle

Oral Administration
Platelet Activation
Platelet Aggregation
Hemorrhage
Immunoreceptor Tyrosine-Based Activation Motif
13 Citations (Scopus)

PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage

Barroso-González, J., Auclair, S., Luan, S., Thomas, L., Atkins, K. M., Aslan, J., Thomas, L. L., Zhao, J., Zhao, Y. & Thomas, G., Mar 4 2016, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
NF-kappa B
DNA Damage
Protein Transport
Mitochondrial Membranes
2015
1 Citation (Scopus)

Data detailing the platelet acetyl-lysine proteome

Aslan, J., David, L. & McCarty, O., Dec 1 2015, In : Data in Brief. 5, p. 368-371 4 p.

Research output: Contribution to journalArticle

regulation
lack
7 Citations (Scopus)

Lysine acetyltransfer supports platelet function

Aslan, J., Rigg, R. A., Nowak, M. S., Loren, C. P., Baker-Groberg, S. M., Pang, J., David, L. & McCarty, O., Oct 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 10, p. 1908-1917 10 p.

Research output: Contribution to journalArticle

Lysine
Blood Platelets
Actins
Acetylation
Proteins

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization

Kosoff, R. E., Aslan, J. E., Kostyak, J. C., Dulaimi, E., Chow, H. Y. E., Prudnikova, T. Y., Radu, M., Kunapuli, S. P., McCarty, O. J. T. & Chernoff, J., May 7 2015, In : Blood. 125, 19, p. 2995-3005 11 p.

Research output: Contribution to journalArticle

Megakaryocytes
Platelets
Cytoskeleton
p21-Activated Kinases
Cofilin 1
20 Citations (Scopus)

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization

Kosoff, R. E., Aslan, J., Kostyak, J. C., Dulaimi, E., Chow, H. Y., Prudnikova, T. Y., Radu, M., Kunapuli, S. P., McCarty, O. & Chernoff, J., 2015, In : Blood. 125, 19, p. 2995-3005 11 p.

Research output: Contribution to journalArticle

Megakaryocytes
Platelets
Cytoskeleton
p21-Activated Kinases
Cofilin 1
27 Citations (Scopus)

The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear

Loren, C. P., Aslan, J., Rigg, R. A., Nowak, M. S., Healy, L. D., Gruber, A., Druker, B. & McCarty, O., Jan 1 2015, In : Thrombosis Research. 135, 1, p. 155-160 6 p.

Research output: Contribution to journalArticle

Immunoreceptor Tyrosine-Based Activation Motif
Platelet Activation
Blood Platelets
Protein-Tyrosine Kinases
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
2013
88 Citations (Scopus)

A physical sciences network characterization of non-tumorigenic and metastatic cells

Agus, D. B., Alexander, J. F., Arap, W., Ashili, S., Aslan, J., Austin, R. H., Backman, V., Bethel, K. J., Bonneau, R., Chen, W. C., Chen-Tanyolac, C., Choi, N. C., Curley, S. A., Dallas, M., Damania, D., Davies, P. C. W., Decuzzi, P., Dickinson, L., Estevez-Salmeron, L., Estrella, V. & 75 others, Ferrari, M., Fischbach, C., Foo, J., Fraley, S. I., Frantz, C., Fuhrmann, A., Gascard, P., Gatenby, R. A., Geng, Y., Gerecht, S., Gillies, R. J., Godin, B., Grady, W. M., Greenfield, A., Hemphill, C., Hempstead, B. L., Hielscher, A., Hillis, W. D., Holland, E. C., Ibrahim-Hashim, A., Jacks, T., Johnson, R. H., Joo, A., Katz, J. E., Kelbauskas, L., Kesselman, C., King, M. R., Konstantopoulos, K., Kraning-Rush, C. M., Kuhn, P., Kung, K., Kwee, B., Lakins, J. N., Lambert, G., Liao, D., Licht, J. D., Liphardt, J. T., Liu, L., Lloyd, M. C., Lyubimova, A., Mallick, P., Marko, J., McCarty, O., Meldrum, D. R., Michor, F., Mumenthaler, S. M., Nandakumar, V., O'Halloran, T. V., Oh, S., Pasqualini, R., Paszek, M. J., Philips, K. G., Poultney, C. S., Rana, K., Reinhart-King, C. A., Ros, R., Semenza, G. L., Senechal, P., Shuler, M. L., Srinivasan, S., Staunton, J. R., Stypula, Y., Subramanian, H., Tlsty, T. D., Tormoen, G. W., Tseng, Y., Van Oudenaarden, A., Verbridge, S. S., Wan, J. C., Weaver, V. M., Widom, J., Will, C., Wirtz, D., Wojtkowiak, J. & Wu, P. H., 2013, In : Scientific Reports. 3, 1449.

Research output: Contribution to journalArticle

Natural Science Disciplines
Neoplasm Metastasis
Cell Line
Mechanics
Proteomics
22 Citations (Scopus)

Histone deacetylase 6-mediated deacetylation of α-tubulin coordinates cytoskeletal and signaling events during platelet activation

Aslan, J., Phillips, K. G., Healy, L. D., Itakura, A., Pang, J. & McCarty, O., Dec 15 2013, In : American Journal of Physiology - Cell Physiology. 305, 12

Research output: Contribution to journalArticle

Histone Deacetylases
Platelet Activation
Tubulin
Blood Platelets
Acetylation
24 Citations (Scopus)

p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils

Itakura, A., Aslan, J., Kusanto, B. T., Phillips, K. G., Porter, J. E., Newton, P. K., Nan, X., Insall, R. H., Chernoff, J. & McCarty, O., Sep 3 2013, In : PLoS One. 8, 9, e73063.

Research output: Contribution to journalArticle

p21-Activated Kinases
neutrophils
phosphotransferases (kinases)
Neutrophils
guanosinetriphosphatase
23 Citations (Scopus)

P21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear

Aslan, J., Itakura, A., Haley, K., Tormoen, G. W., Loren, C. P., Baker, S. M., Pang, J., Chernoff, J. & McCarty, O., Jul 2013, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 7, p. 1544-1551 8 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
Pseudopodia
Platelet Aggregation
Glycoproteins
Platelet Activation
3 Citations (Scopus)

Rac and Cdc42 team up for platelets

Aslan, J. & McCarty, O., Oct 31 2013, In : Blood. 122, 18, p. 3096-3097 2 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Megakaryocytes
Platelets
Blood
Blood Platelets
75 Citations (Scopus)

Rho GTPases in platelet function

Aslan, J. & McCarty, O., Jan 2013, In : Journal of Thrombosis and Haemostasis. 11, 1, p. 35-46 12 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Blood Platelets
Monomeric GTP-Binding Proteins
Platelet Activation
Cell Surface Receptors
24 Citations (Scopus)

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation

Aslan, J., Baker, S. M., Loren, C. P., Haley, K., Itakura, A., Pang, J., Greenberg, D. L., David, L., Manser, E., Chernoff, J. & McCarty, O., Sep 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 5

Research output: Contribution to journalArticle

p21-Activated Kinases
rho GTP-Binding Proteins
Platelet Activation
Thrombin
Blood Platelets
2012
31 Citations (Scopus)

Platelet shape change and spreading

Aslan, J., Itakura, A., Gertz, J. M. & McCarty, O., 2012, Methods in Molecular Biology. Vol. 788. p. 91-100 10 p. (Methods in Molecular Biology; vol. 788).

Research output: Chapter in Book/Report/Conference proceedingChapter

Blood Platelets
Interference Microscopy
Pseudopodia
Platelet Activation
Hemostasis
11 Citations (Scopus)

Regulation of the mTOR-Rac1 axis in platelet function

Aslan, J. & McCarty, O., Jan 2012, In : Small GTPases. 3, 1

Research output: Contribution to journalArticle

Platelets
Blood Platelets
Platelet Membrane Glycoproteins
rho GTP-Binding Proteins
Pseudopodia
2011
13 Citations (Scopus)

Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets

Aslan, J., Spencer, A. M., Loren, C. P., Pang, J., Welch, H. C., Greenberg, D. L. & McCarty, O., Sep 1 2011, In : Journal of Molecular Signaling. 6, 11.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Platelets
Blood Platelets
rac1 GTP-Binding Protein
rho GTP-Binding Proteins
17 Citations (Scopus)

Promotion of experimental thrombus formation by the procoagulant activity of breast cancer cells

Berny-Lang, M. A., Aslan, J., Tormoen, G. W., Patel, I. A., Bock, P. E., Gruber, A. & McCarty, O., 2011, In : Physical Biology. 8, 1, 015014.

Research output: Contribution to journalArticle

Thrombosis
Circulating Neoplastic Cells
Breast Neoplasms
Thromboplastin
Thrombin
64 Citations (Scopus)

S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation

Aslan, J., Tormoen, G. W., Loren, C. P., Pang, J. & McCarty, O., Sep 15 2011, In : Blood. 118, 11, p. 3129-3136 8 p.

Research output: Contribution to journalArticle

Platelet Activation
Platelets
Platelet Aggregation
Blood Platelets
Agglomeration
2010
15 Citations (Scopus)

Characterization of human platelet binding of recombinant T cell receptor ligand

Itakura, A., Aslan, J., Sinha, S., White-Adams, T. C., Patel, I. A., Meza-Romero, R., Vandenbark, A., Burrows, G. G., Offner, H. & McCarty, O., Nov 8 2010, In : Journal of Neuroinflammation. 7, 75.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Blood Platelets
Ligands
Thrombosis
Collagen
2009
44 Citations (Scopus)

Akt and 14-3-3 Control a PACS-2 Homeostatic Switch that Integrates Membrane Traffic with TRAIL-Induced Apoptosis

Aslan, J., You, H., Williamson, D. M., Endig, J., Youker, R. T., Thomas, L., Shu, H., Du, Y., Milewski, R. L., Brush, M. H., Possemato, A., Sprott, K., Fu, H., Greis, K. D., Runckel, D. N., Vogel, A. & Thomas, G., May 14 2009, In : Molecular Cell. 34, 4, p. 497-509 13 p.

Research output: Contribution to journalArticle

Apoptosis
Membranes
Hepatocytes
Neoplasms
Homeostasis
36 Citations (Scopus)

Death by committee: Organellar trafficking and communication in apoptosis

Aslan, J. & Thomas, G., Oct 2009, In : Traffic. 10, 10, p. 1390-1404 15 p.

Research output: Contribution to journalArticle

Cell death
Caspases
Organelles
Cell Death
Apoptosis
2006
26 Citations (Scopus)

Sustained phosphorylation of Bid is a marker for resistance to fas-induced apoptosis during chronic liver diseases

Vogel, A., Aslan, J., Willenbring, H., Klein, C., Finegold, M., Mount, H., Thomas, G. & Grompe, M., Jan 2006, In : Gastroenterology. 130, 1, p. 104-119 16 p.

Research output: Contribution to journalArticle

Liver Diseases
Chronic Disease
Phosphorylation
Apoptosis
Cholestasis
2005

Erratum: PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis (EMBO Journal (2005) 24 (717-729) doi:10.1038/sj.emboj.7600559)

Simmen, T., Aslan, J., Blagoveshchenskaya, A. D., Thomas, L., Wan, L., Xiang, Y., Feliciangeli, S. F., Hung, C. H., Crump, C. M. & Thomas, G., Mar 23 2005, In : EMBO Journal. 24, 6, p. 1301 1 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Mitochondria
Apoptosis
299 Citations (Scopus)

PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis

Simmen, T., Aslan, J., Blagoveshchenskaya, A. D., Thomas, L., Wan, L., Xiang, Y., Feliciangeli, S. F., Hung, C. H., Crump, C. M. & Thomas, G., Feb 23 2005, In : EMBO Journal. 24, 4, p. 717-729 13 p.

Research output: Contribution to journalArticle

Picture archiving and communication systems
Mitochondria
Endoplasmic Reticulum
Apoptosis
Communication