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John Williams

Professor

  • 13216 Citations
  • 64 h-Index
1976 …2020
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  • 27 Similar Profiles
Neurons Medicine & Life Sciences
Locus Coeruleus Medicine & Life Sciences
Opioid Analgesics Medicine & Life Sciences
Opioid Receptors Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
Dopamine Medicine & Life Sciences
Morphine Medicine & Life Sciences
Potassium Medicine & Life Sciences

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Projects 1987 2020

COCAINE--EFFECTS ON SINGLE NEURONS

Williams, J.

National Institutes of Health

7/1/87 → 5/31/20

Project: Research project

Cocaine
Neurons
Dopamine
Ventral Tegmental Area
Locus Coeruleus

Covalent labeling endogenous G-protein coupled receptors in living cells

Williams, J.

Project: Research project

Genetically encoded indicators for large-scale sensing of neuromodulatory signaling in behaving animals

Williams, J.

Project: Research project

Opioid Sensitive GABA inputs to the Ventral Midbrain

Williams, J.

National Institutes of Health

9/15/12 → 7/31/17

Project: Research project

Mesencephalon
gamma-Aminobutyric Acid
Opioid Analgesics
Afferent Pathways
Dopaminergic Neurons

Agonist selective activation of Mu-opioid receptors

Williams, J.

National Institutes of Health

5/1/09 → 4/30/12

Project: Research project

mu Opioid Receptor
Opioid Analgesics
HEK293 Cells
Pharmacology
Pain Clinics

Research Output 1976 2019

  • 13216 Citations
  • 64 h-Index
  • 180 Article
  • 2 Conference contribution
  • 1 Review article
9 Citations (Scopus)

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Kliewer, A., Schmiedel, F., Sianati, S., Bailey, A., Bateman, J. T., Levitt, E. S., Williams, J., Christie, M. J. & Schulz, S., Dec 1 2019, In : Nature Communications. 10, 1, 367.

Research output: Contribution to journal › Article

analgesia
phosphorylation
Phosphorylation
Opioid Receptors
GTP-Binding Proteins
1 Citation (Scopus)

RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain

Robinson, B. G., Cai, X., Wang, J., Bunzow, J. R., Williams, J. T. & Kaeser, P. S., Sep 2019, In : eLife. 8, e47972.

Research output: Contribution to journal › Article

Open Access
Reaction injection molding
Mesencephalon
Dopamine
Action Potentials
Neurotransmitter Agents

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

Arttamangkul, S., Plazek, A., Platt, E. J., Jin, H., Murray, T. F., Birdsong, W. T., Rice, K. C., Farrens, D. L. & Williams, J. T., Oct 7 2019, In : eLife. 8

Research output: Contribution to journal › Article

Open Access
Opioid Receptors
Neurons
Ligands
Fluorescent Dyes
Labeling
5 Citations (Scopus)

Cellular tolerance at the µ-opioid receptor is phosphorylation dependent

Arttamangkul, S., Heinz, D. A., Bunzow, J. R., Song, X. & Williams, J., Mar 28 2018, In : eLife. 7, e34989.

Research output: Contribution to journal › Article

Phosphorylation
Opioid Receptors
Morphine
Wild Animals
Locus Coeruleus

Desensitization and Tolerance of Mu Opioid Receptors on Pontine Kölliker-Fuse Neurons

Levitt, E. S. & Williams, J., Jan 1 2018, In : Molecular Pharmacology. 93, 1, p. 8-13 6 p.

Research output: Contribution to journal › Article

mu Opioid Receptor
Neurons
Locus Coeruleus
Morphine
Opioid Analgesics