John Williams

Professor

  • 13724 Citations
  • 65 h-Index
1976 …2020

Research output per year

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Research Output

2020

Photoactivatable Dopamine and Sulpiride to Explore the Function of Dopaminergic Neurons and Circuits

Asad, N., Mclain, D. E., Condon, A. F., Gore, S., Hampton, S. E., Vijay, S., Williams, J. T. & Dore, T. M., Mar 18 2020, In : ACS Chemical Neuroscience. 11, 6, p. 939-951 13 p.

Research output: Contribution to journalArticle

Open Access
2019

Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators

Patriarchi, T., Cho, J. R., Merten, K., Marley, A., Broussard, G. J., Liang, R., Williams, J., Nimmerjahn, A., von Zastrow, M., Gradinaru, V. & Tian, L., Dec 1 2019, In : Nature protocols. 14, 12, p. 3471-3505 35 p.

Research output: Contribution to journalArticle

3 Scopus citations

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Kliewer, A., Schmiedel, F., Sianati, S., Bailey, A., Bateman, J. T., Levitt, E. S., Williams, J. T., Christie, M. J. & Schulz, S., Dec 1 2019, In : Nature communications. 10, 1, 367.

Research output: Contribution to journalArticle

38 Scopus citations

RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain

Robinson, B. G., Cai, X., Wang, J., Bunzow, J. R., Williams, J. T. & Kaeser, P. S., Sep 2019, In : eLife. 8, e47972.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

Arttamangkul, S., Plazek, A., Platt, E. J., Jin, H., Murray, T. F., Birdsong, W. T., Rice, K. C., Farrens, D. L. & Williams, J. T., Oct 7 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Cellular tolerance at the µ-opioid receptor is phosphorylation dependent

Arttamangkul, S., Heinz, D. A., Bunzow, J. R., Song, X. & Williams, J., Mar 28 2018, In : eLife. 7, e34989.

Research output: Contribution to journalArticle

13 Scopus citations

Desensitization and tolerance of Mu opioid receptors on pontine kölliker-fuse neurons

Levitt, E. S. & Williams, J. T., Jan 2018, In : Molecular pharmacology. 93, 1, p. 8-13 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area

Gantz, S. C., Ford, C. P., Morikawa, H. & Williams, J., Feb 10 2018, In : Annual Review of Physiology. 80, p. 219-241 23 p.

Research output: Contribution to journalReview article

18 Scopus citations

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

Patriarchi, T., Cho, J. R., Merten, K., Howe, M. W., Marley, A., Xiong, W. H., Folk, R. W., Broussard, G. J., Liang, R., Jang, M. J., Zhong, H., Dombeck, D., von Zastrow, M., Nimmerjahn, A., Gradinaru, V., Williams, J. T. & Tian, L., Jun 29 2018, In : Science. 360, 6396, eaat4422.

Research output: Contribution to journalArticle

132 Scopus citations
2017

Cholinergic interneurons underlie spontaneous dopamine release in nucleus accumbens

Yorgason, J. T., Zeppenfeld, D. M. & Williams, J., Feb 22 2017, In : Journal of Neuroscience. 37, 8, p. 2086-2096 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors

Robinson, B. G., Condon, A. F., Radl, D., Borrelli, E., Williams, J. T. & Neve, K. A., Nov 20 2017, In : eLife. 6, e31924.

Research output: Contribution to journalArticle

3 Scopus citations

Desensitized D2 autoreceptors are resistant to trafficking

Robinson, B. G., Bunzow, J. R., Grimm, J. B., Lavis, L. D., Dudman, J. T., Brown, J., Neve, K. A. & Williams, J. T., Dec 1 2017, In : Scientific Reports. 7, 1, 4379.

Research output: Contribution to journalArticle

12 Scopus citations

Presynaptic gain control by endogenous cotransmission of dopamine and GABA in the olfactory bulb

Vaaga, C. E., Yorgason, J. T., Williams, J. & Westbrook, G., Mar 1 2017, In : Journal of Neurophysiology. 117, 3, p. 1163-1170 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Two-color, one-photon uncaging of glutamate and GABA

Passlick, S., Kramer, P. F., Richers, M. T., Williams, J. T. & Ellis-Davies, G. C. R., Nov 2017, In : PloS one. 12, 11, e0187732.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Calcium Release from Stores Inhibits GIRK

Kramer, P. F. & Williams, J., Dec 20 2016, In : Cell Reports. 17, 12, p. 3246-3255 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Agonist binding and desensitization of the μ-opioid receptor is modulated by phosphorylation of the C-terminal tail domain

Birdsong, W. T., Arttamangkul, S., Bunzow, J. R. & Williams, J. T., Oct 1 2015, In : Molecular pharmacology. 88, 4, p. 816-824 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cocaine Decreases Metabotropic Glutamate Receptor mGluR1 Currents in Dopamine Neurons by Activating mGluR5

Kramer, P. F. & Williams, J. T., Sep 14 2015, In : Neuropsychopharmacology. 40, 10, p. 2418-2424 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Depression of serotonin synaptic transmission by the dopamine Precursor L-DOPA

Gantz, S. C., Levitt, E. S., Llamosas, N., Neve, K. A. & Williams, J. T., Jan 1 2015, In : Cell Reports. 12, 6, p. 944-954 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium

Gantz, S. C., Robinson, B. G., Buck, D. C., Bunzow, J. R., Neve, R. L., Williams, J. T. & Neve, K. A., Aug 26 2015, In : eLife. 4, AUGUST2015, e09358.

Research output: Contribution to journalArticle

23 Scopus citations

Does PKC activation increase the homologous desensitization of μ opioid receptors?

Arttamangkul, S., Birdsong, W. & Williams, J. T., Jan 2015, In : British Journal of Pharmacology. 172, 2, p. 583-592 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

μ opioid receptor activation hyperpolarizes respiratory-controlling Kölliker-Fuse neurons and suppresses post-inspiratory drive

Levitt, E. S., Abdala, A. P., Paton, J. F. R., Bissonnette, J. M. & Williams, J. T., Oct 1 2015, In : Journal of Physiology. 593, 19, p. 4453-4469 17 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

Desensitization of functional μ-opioid receptors increases agonist off-rate

Williams, J. T., Jul 2014, In : Molecular pharmacology. 86, 1, p. 52-61 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal

Matsui, A., Jarvie, B. C., Robinson, B. G., Hentges, S. T. & Williams, J. T., Jun 18 2014, In : Neuron. 82, 6, p. 1346-1356 11 p.

Research output: Contribution to journalArticle

84 Scopus citations

The rare DAT coding variant Val559 perturbs da neuron function, changes behavior, and alters in vivo responses to psychostimulants

Mergy, M. A., Gowrishankar, R., Gresch, P. J., Gantz, S. C., Williams, J., Davis, G. L., Wheeler, C. A., Stanwood, G. D., Hahn, M. K. & Blakely, R. D., Nov 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 44, p. E4779-E4788

Research output: Contribution to journalArticle

29 Scopus citations
2013

A selective 5-HT1a receptor agonist improves respiration in a mouse model of Rett syndrome

Levitt, E. S., Hunnicutt, B. J., Knopp, S. J., Williams, J. T. & Bissonnette, J. M., Dec 1 2013, In : Journal of Applied Physiology. 115, 11, p. 1626-1633 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Caged naloxone reveals opioid signaling deactivation kineticss

Banghart, M. R., Williams, J. T., Shah, R. C., Lavis, L. D. & Sabatini, B. L., Nov 2013, In : Molecular pharmacology. 84, 5, p. 687-695 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure

Birdsong, W. T., Arttamangkul, S., Clark, M. J., Cheng, K., Rice, K. C., Traynor, J. R. & Williams, J. T., Feb 27 2013, In : Journal of Neuroscience. 33, 9, p. 4118-4127 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Regulation of μ-opioid receptors: Desensitization, phosphorylation, internalization, and tolerance

Williams, J. T., Ingram, S. L., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C. J. & Christie, M. J., 2013, In : Pharmacological Reviews. 65, 1, p. 223-254 32 p.

Research output: Contribution to journalReview article

357 Scopus citations

Spontaneous inhibitory synaptic currents mediated by a g protein-coupled receptor

Gantz, S. C., Bunzow, J. R. & Williams, J. T., Jun 5 2013, In : Neuron. 78, 5, p. 807-812 6 p.

Research output: Contribution to journalArticle

44 Scopus citations
2012

Desensitization and trafficking of μ-opioid receptors in locus ceruleus neurons: Modulation by kinases

Arttamangkul, S., Lau, E. K., Lu, H. W. & Williams, J. T., Mar 2012, In : Molecular pharmacology. 81, 3, p. 348-355 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Modulating Neuromodulation by Receptor Membrane Traffic in the Endocytic Pathway

von Zastrow, M. & Williams, J. T., Oct 4 2012, In : Neuron. 76, 1, p. 22-32 11 p.

Research output: Contribution to journalReview article

34 Scopus citations

Morphine desensitization and cellular tolerance are distinguished in rat locus ceruleus neurons

Levitt, E. S. & Williams, J. T., Nov 2012, In : Molecular pharmacology. 82, 5, p. 983-992 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Neuroscience: Promiscuous vesicles

Williams, J. T., Oct 11 2012, In : Nature. 490, 7419, p. 178-179 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons

Deignan, J., Luján, R., Bond, C., Riegel, A., Watanabe, M., Williams, J. T., Maylie, J. & Adelman, J. P., Aug 16 2012, In : Neuroscience. 217, p. 67-76 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
2011

Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway

Gantz, S. C., Ford, C. P., Neve, K. A. & Williams, J. T., Aug 31 2011, In : Journal of Neuroscience. 31, 35, p. 12629-12637 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Opioid-sensitive GABA inputs from rostromedial tegmental nucleus synapse onto midbrain dopamine neurons

Matsui, A. & Williams, J. T., Nov 30 2011, In : Journal of Neuroscience. 31, 48, p. 17729-17735 7 p.

Research output: Contribution to journalArticle

98 Scopus citations

Recovery from μ-opioid receptor desensitization after chronic treatment with morphine and methadone

Quillinan, N., Lau, E. K., Virk, M., Von Zastrow, M. & Williams, J. T., Mar 23 2011, In : Journal of Neuroscience. 31, 12, p. 4434-4443 10 p.

Research output: Contribution to journalArticle

61 Scopus citations
2010
21 Scopus citations

Control of extracellular dopamine at dendrite and axon terminals

Ford, C. P., Gantz, S. C., Phillips, P. E. M. & Williams, J. T., May 19 2010, In : Journal of Neuroscience. 30, 20, p. 6975-6983 9 p.

Research output: Contribution to journalArticle

79 Scopus citations
2009

Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization

Virk, M. S., Arttamangkul, S., Birdsong, W. T. & Williams, J. T., Jun 3 2009, In : Journal of Neuroscience. 29, 22, p. 7341-7348 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

CRF enhancement of GIRK channel-mediated transmission in dopamine neurons

Beckstead, M. J., Gantz, S. C., Ford, C. P., Stenzel-Poore, M. P., Phillips, P. E. M., Mark, G. P. & Williams, J. T., Jul 1 2009, In : Neuropsychopharmacology. 34, 8, p. 1926-1935 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of μ-opioid receptors in CNS neurons

Yu, Y. J., Arttamangkul, S., Evans, C. J., Williams, J. T. & Von Zastrow, M., Jan 7 2009, In : Journal of Neuroscience. 29, 1, p. 222-233 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

The time course of dopamine transmission in the ventral tegmental area

Ford, C. P., Phillips, P. E. M. & Williams, J. T., Oct 21 2009, In : Journal of Neuroscience. 29, 42, p. 13344-13352 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
2008

Agonist-specific regulation of μ-opioid receptor desensitization and recovery from desensitization

Virk, M. S. & Williams, J. T., Apr 1 2008, In : Molecular pharmacology. 73, 4, p. 1301-1308 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

CRF Facilitates Calcium Release from Intracellular Stores in Midbrain Dopamine Neurons

Riegel, A. C. & Williams, J. T., Feb 28 2008, In : Neuron. 57, 4, p. 559-570 12 p.

Research output: Contribution to journalArticle

62 Scopus citations

Differential activation and trafficking of μ-opioid receptors in brain slices

Arttamangkul, S., Quillinan, N., Low, M. J., Von Zastrow, M., Pintar, J. & Williams, J. T., Oct 1 2008, In : Molecular pharmacology. 74, 4, p. 972-979 8 p.

Research output: Contribution to journalArticle

85 Scopus citations

Mesoprefrontal Dopamine Neurons Distinguish Themselves

Ford, C. P. & Williams, J. T., Mar 13 2008, In : Neuron. 57, 5, p. 631-632 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations

Morphine produces circuit-specific neuroplasticity in the bed nucleus of the stria terminalis

Dumont, É. C., Rycroft, B. K., Maiz, J. & Williams, J. T., Apr 22 2008, In : Neuroscience. 153, 1, p. 232-239 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: A study of GIRK-knockout mice

Torrecilla, M., Quillinan, N., Williams, J. T. & Wickman, K., Aug 1 2008, In : European Journal of Neuroscience. 28, 3, p. 618-624 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
2007

Decreased vesicular somatodendritic dopamine stores in leptin-deficient mice

Roseberry, A. G., Painter, T., Mark, G. P. & Williams, J. T., Jun 27 2007, In : Journal of Neuroscience. 27, 26, p. 7021-7027 7 p.

Research output: Contribution to journalArticle

45 Scopus citations